All 3 patients had two additional atherosclerotic or nonatherosclerotic risk factors for stroke, suggesting that vertebral artery hypoplasia combined with other conventional risk factors may provide an optimal background for brainstem ischemia.
Category B anti-headache medications include Tylenol (acetaminophen); Reglan (metoclopramide), which is used for nausea but also may relieve a mild headache; and over-the-counter non-steroidal anti-inflammatory drugs such as Advil and Motrin (ibuprofen) or Aleve (naproxen) only during the first and second trimesters.
Tizanidine is used in the treatment of muscle spasm; cluster headaches and belongs to the drug class skeletal muscle relaxants. Risk cannot be ruled out during pregnancy. Tizanidine 4 mg is classified as a Schedule N controlled substance under the Controlled Substance Act (CSA).