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Zoledronic Acid (Reclast) ZOLEDRONIC ACID (Reclast) Zoledronic acid is a bisphosphonate prescribed to prevent or treat osteoporosis or Paget's disease. Unlike other common bisphosphonates that are taken by mouth, Reclast bypasses the stomach because it is an infusion into the bloodstream. Bone is a living tissue constantly being remodeled.
1 Reclast infusion is an injection of zoledronic acid that is given over a short period of time, usually 15 to 30 minutes. 2  It is sometimes used to treat osteoporosis and is usually administered once yearly. 3  When used for treating Pagetâs Disease, it may be given more often.