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Folliculogenesis is the process in which a recruited primordial follicle grows and develops into a specialized graafian follicle with the potential to either ovulate its egg into the oviduct at mid-cycle to be fertilized or to die by atresia.
The rate of preantral follicle development is slow, requiring about 300 days for a recruited primordial follicle to complete the whole preantral period (Fig. 2). A long doubling time (about 10 days) for the granulosa cells is responsible for the slow growth rate. After antrum formation in the class 3 follicle (about 0.4 mm in diameter), the rate of growth accelerates (Fig. 2).