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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
Without treatment, women with a BRCA gene mutation are seven times more likely to get breast cancer and 30 times more likely to get ovarian cancer before age 70 than other women. What Is the Know:BRCA tool? The Know:BRCA online tool is a resource developed to help women understand their risks for having a BRCA1 or BRCA2 gene mutation. How the Know:BRCA Tool Works. The Know:BRCA tool estimates your chance of having a BRCA gene mutation based on your personal and family history of cancer. It looks at how many people in your family have had breast or ovarian cancer, how they are related to you, and how old they were when they got cancer.