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What areas did the Lewis and Clark expedition and the Pike expedition explore? Lewis and Clark explored the Northern part of the Louisiana Purchase, traveling up the Missouri River, and Pike explored the southern half, looking for the start of the Red River. Why were Meriwether Lewis and William Clark chosen to lead the exploration of the Louisiana Purchase? Lewis was chosen because of his experience as a leader, and Clark was chosen for his mapmaking skills.
The Lewis and Clark Expedition was undertaken in order to explore the Louisiana Purchase, learn about the plants and animals of the West, and Attempt to find a river route to the Pacific Ocean. 4.