At admission, 46 patients displayed an enduring deficit syndrome, which includes lack of emotion, absence of interest in social activities, sparse communication with others, and little sense of purpose in life.
The islet density routes throughout the healthy human pancreas. The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (i.e., hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans.
Langerhans cells are dendritic cells (antigen-presenting immune cells) of the skin and mucosa, and contain large organelles called Birbeck granules. They are present in all layers of the epidermis, but are most prominent in the stratum spinosum.