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Suboxone is made of two drugs-buprenorphine and naloxone. The buprenorphine is what sticks around in your system and prevents withdrawl. It has a 36 hour half-life. So if yo â¦ u took 2mg of suboxone one time only, 36 hours later you'd have 1mg left in your system. 36 hours after that you'd have .5 mg in your system.
How long does Suboxone stay in your system? Suboxone lasts long enough that you only have to use it once a day. Based on the buprenorphine content, this medicine has a half-life of 24 to 42 hours. This means that it takes 24 to 42 hours for the level of buprenorphine to drop by 50 percent in your blood.Therefore, it may take several days, or even a week or longer, for this drug to be mostly out of your system.(Click Suboxone for more information on how long this drug stays in your system.his means that it takes 24 to 42 hours for the level of buprenorphine to drop by 50 percent in your blood. Therefore, it may take several days, or even a week or longer, for this drug to be mostly out of your system.