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Gluconeogenesis is a pivotal biochemical pathway in which glucose is synthesised from nonâcarbohydrate precursors, that is, lactate, alanine, glutamine and glycerol, during prolonged starvation.
This system fails when insulin secretion or when the body's responsiveness is no longer coupled to blood glucose levels. The livers gluconeogenesis progresses without alteration following reduction or loss of the insulin signal, releasing sugar in spite of high blood glucose levels.