Tay-Sachs is a disease of the central nervous system; it is a neurodegenerative disorder. Tay-Sachs most commonly affects infants. In infants, it is a progressive disease that is unfortunately always fatal. Rarely, Tay-Sachs can occur in teens and adults, causing less severe symptoms. defective gene on chromosome 15 causes Tay-Sachs disease. This defective gene causes the body to not make a protein called hexosaminidase A. Without this protein, chemicals called gangliosides build up in nerve cells in the brain, destroying brain cells.
The irritated nerves can cause significant pain. Sciatica, a painful inflammation of the sciatic nerve, is typically experienced on one side of the body, and can travel from your lower back down your leg to your feet or even toes. Sciatica is difficult to diagnose and sometimes goes away on its own.
Sciatica. Any disorder of the sciatic nerve will cause lower back and leg pain. Sciatica is characterized by leg numbness, tingling feet and toes, pain or weakness on the foot or leg on one side and sometimes even on both sides.Pain in the buttocks and the lower back is also to be expected.There are different causes of sciatic pain.eg Numbness Treatment. Most cases of foot and leg numbness, tingling and pain cannot be resolved if the cause is not treated. Treatments differ for each case, ranging from altering the patientâs activities, to taking in medication for the pain and inflammation, to surgery, or a combination of these.