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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
Of those, ~85% are due to mutations in the BRCA genes, which cause hereditary breast and ovarian cancer. 1 in 40 Ashkenazi Jews carry a mutation in the BRCA genes. There are three specific mutaÂ­tions (two in the BRCA1 gene and one in the BRCA2 gene) in the Ashkenazi Jewish population.