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Effect of prednisone on thyroid gland morphology and plasma thyroxine and triiodothyronine concentrations in the dog. Woltz HH, Thompson FN, Kemppainen RJ, Munnell JF, Lorenz MD.
Being a corticosteroid, prednisone may cause serious side effects if given for longer periods of time: 1  Secondary infections, which the dog is more susceptible to due to the suppressed immune system. 2  Increased thirst and appetite. 3  Fluid retention.  Hormonal irregularities, leading to acne, oily skin or dry, flaky 1  skin. Liver damage.  Kidney damage.