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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
Women who inherit a mutation in the BRCA1 or BRCA2 gene have a much higher risk of developing breast and/or ovarian cancer. But, important steps can be taken to help lower the risk for cancer in these women. Note that not everyone who inherits a BRCA1 or BRCA2 mutation will get breast or ovarian cancer.