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Most cases of Angelman syndrome (about 70 percent) occur when a segment of the maternal chromosome 15 containing this gene is deleted. In other cases (about 11 percent), Angelman syndrome is caused by a mutation in the maternal copy of the UBE3A gene.In a small percentage of cases, Angelman syndrome results when a person inherits two copies of chromosome 15 from his or her father (paternal copies) instead of one copy from each parent.ost cases of Angelman syndrome are not inherited, particularly those caused by a deletion in the maternal chromosome 15 or by paternal uniparental disomy. These genetic changes occur as random events during the formation of reproductive cells (eggs and sperm) or in early embryonic development.
Examples of Diseases Caused by Insertion Mutations. Having nonfunctional proteins means that something in the body is not working properly. This can lead to disease. Let's look at a few examples of genetic diseases in humans that are the result of insertion mutations.nsertion mutations occur when extra genetic material is added to a DNA sequence. Learn about insertion mutations and some of the diseases they can cause in this lesson.