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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
For the majority of families who do not harbour BRCA1 or BRCA2 mutations, it is considered likely that a number of genetic factors, each with a small cumulative contribution, are responsible. Five to 10 per cent of breast cancer patients have an inheritable form of breast cancer due to a mutation in BRCA1 or BRCA2.