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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
BRCA1 and BRCA2 (BReast CAncer genes 1 and 2) are the best-known genes linked to breast cancer risk. Everyone has these genes, but some people have an inherited mutation in one or both that increases the risk of breast cancer. In addition to mutations in BRCA1 and BRCA2 (BRCA1/2) genes, mutations in the following genes can increase the risk of breast cancer: