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Mild to mod- 6-8 wks: Mild to moderate sprains of knee ligaments that are appropriately treated nonoperatively should generally heal in 6-8 weeks. Not all ligament sprains are the same, and actual time to healing will vary based upon severity. Most typical knee mcl sprains (grade 2-3) heal in 6-8 weeks.et help from a doctor now âº. Sprain: That depends on what is sprained and the severity of injury. Minor sprain can be a few weeks. More severe injury can be months -- or never as may need surgery to fix (acl, meniscus, etc).
2 doctors agreed: It depends: Full recovery after knee replacement usually takes more than a year. Most patients reduce their use of pain medicines within two weeks of the replacement, by 6 weeks they are comfortable and usually by 3 months the knee is fading into the background, and life doesn't revolve around the new knee. Everyone is different and this is a general time line.