Tay-Sachs is a disease of the central nervous system; it is a neurodegenerative disorder. Tay-Sachs most commonly affects infants. In infants, it is a progressive disease that is unfortunately always fatal. Rarely, Tay-Sachs can occur in teens and adults, causing less severe symptoms. defective gene on chromosome 15 causes Tay-Sachs disease. This defective gene causes the body to not make a protein called hexosaminidase A. Without this protein, chemicals called gangliosides build up in nerve cells in the brain, destroying brain cells.
The irritated nerves can cause significant pain. Sciatica, a painful inflammation of the sciatic nerve, is typically experienced on one side of the body, and can travel from your lower back down your leg to your feet or even toes. Sciatica is difficult to diagnose and sometimes goes away on its own.
Numerous conditions can cause bilateral lower leg pain. Photo Credit legs image by Leticia Wilson from Fotolia.com. Bilateral lower leg pain is pain in both legs, anywhere between the knees and the ankles. According to MayoClinic.com, leg pain can manifest anywhere from the hips to the ankles, and it may be caused by structures or tissues in other parts of the body, such as the lower back or feet. The lower leg is the area between the knees and the ankles.