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Gluconeogenesis is a pivotal biochemical pathway in which glucose is synthesised from nonâcarbohydrate precursors, that is, lactate, alanine, glutamine and glycerol, during prolonged starvation.
Gluconeogenesis. The net effect of gluconeogenesis is the reversal of glycolysis. In gluconeogenesis, glucose is synthesized from smaller precursors. Now that you have learned about G and values, you can have an appreciation for the difficulty a cell has in simply reversing a pathway.hy is it important to have glycolysis off when gluconeogenesis is on? Consider what happens if both pathways are operating in a cycle. (See Figure 16.3) One starts with a glucose molecule, breaks it to 2 pyruvates in glycolysis and then resynthesizes glucose from the two pyruvates via gluconeogenesis.