Tay-Sachs is a disease of the central nervous system; it is a neurodegenerative disorder. Tay-Sachs most commonly affects infants. In infants, it is a progressive disease that is unfortunately always fatal. Rarely, Tay-Sachs can occur in teens and adults, causing less severe symptoms. defective gene on chromosome 15 causes Tay-Sachs disease. This defective gene causes the body to not make a protein called hexosaminidase A. Without this protein, chemicals called gangliosides build up in nerve cells in the brain, destroying brain cells.
The irritated nerves can cause significant pain. Sciatica, a painful inflammation of the sciatic nerve, is typically experienced on one side of the body, and can travel from your lower back down your leg to your feet or even toes. Sciatica is difficult to diagnose and sometimes goes away on its own.
Pain in the legs may be due to injury or inflammation of any of the structures that are found in the leg, including bones, joints, muscles, tendons, ligaments, blood vessels, nerves, and skin. Inflammation of tissues is usually the cause of pain.Pain can also radiate from other parts of the body and be felt in the leg.Back ailments can cause pain and numbness of the leg. Abdominal aorta and iliac artery aneurysms can also present with leg pain.nflammation of tissues is usually the cause of pain. Pain can also radiate from other parts of the body and be felt in the leg. Back ailments can cause pain and numbness of the leg. Abdominal aorta and iliac artery aneurysms can also present with leg pain.