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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
When a person is found to have a mutation in one of these genes, there are special recommendations for breast cancer screening, risk-lowering options and care. So, genetic testing for BRCA1/2 mutations can affect a personâs medical care.Inherited gene mutations in some other genes (such as p53, CHEK2, ATM and PALB2) also increase breast cancer risk. Testing for some of these mutations exists.o, genetic testing for BRCA1/2 mutations can affect a personâs medical care. Inherited gene mutations in some other genes (such as p53, CHEK2, ATM and PALB2) also increase breast cancer risk. Testing for some of these mutations exists.