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Osteoarthritis is a joint disease that mostly affects cartilage. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage allows bones to glide over each other. It also helps absorb shock of movement.
Why study osteoclasts? When osteoclasts work harder than they should bone loss will result. Examples of this are found in the diseases osteoporosis, cancer-induced bone disease, periodontitis, or rheumatoid arthritis. There are also diseases in which osteoclasts do not work hard enough, such as in the condition osteopetrosis.