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As âtoxic overloadâ overwhelms the body, putrefied waste and mucoid plaque form on the walls of the intestines. Keeping the blood clean and pure becomes harder and harder as the colon slows from the invasion of toxins. When the colon becomes impacted or weakened, the normal channels of elimination cease to function.
Back to Top Causes. Toxic megacolon occurs as a complication of inflammatory bowel disease, such as ulcerative colitis and Crohnâs disease, and infections of the colon. The term toxic means that this complication occurs with infection or inflammation and is very dangerous.This is not the same as other forms of megacolon, such as pseudo-obstruction, acute colonic ileus, or congenital colonic dilation. These conditions occur without infection or inflammation.he term toxic means that this complication occurs with infection or inflammation and is very dangerous. This is not the same as other forms of megacolon, such as pseudo-obstruction, acute colonic ileus, or congenital colonic dilation. These conditions occur without infection or inflammation.