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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
In addition to breast cancer, mutations in the BRCA1 gene also increase the risk of ovarian cancer, prostate cancer, and colon cancer. The BRCA1 gene is located on chromosome 17q21 -- the long (q) arm of chromosome 17 at position 21.The symbol BRCA stands for BReast CAncer.n addition to breast cancer, mutations in the BRCA1 gene also increase the risk of ovarian cancer, prostate cancer, and colon cancer. The BRCA1 gene is located on chromosome 17q21 -- the long (q) arm of chromosome 17 at position 21.