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The study began with an open-label dose optimization period (4 to 6 weeks) with an initial QUILLIVANT XR dose of 20 mg once daily in the morning. The dose could be titrated weekly in increments of 10 or 20 mg until a therapeutic dose or the maximum dose of 60 mg/day was reached.
The recommended starting dose of bupropion XL when treating depression is bupropion XL 150 mg, taken once daily in the morning. As soon as the fourth day, your healthcare provider may increase your dose to bupropion XL 300 mg a day. To help avoid seizures, the maximum recommended dose is 450 mg a day. Also, your healthcare provider should increase your dose slowly. For people with liver problems (such as liver failure or cirrhosis), the maximum bupropion XL dose is 100 mg, taken once daily, or 150 mg, taken every other day.