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Gluconeogenesis is a pivotal biochemical pathway in which glucose is synthesised from nonâcarbohydrate precursors, that is, lactate, alanine, glutamine and glycerol, during prolonged starvation.
Gluconeogenesis. The net effect of gluconeogenesis is the reversal of glycolysis. In gluconeogenesis, glucose is synthesized from smaller precursors. Now that you have learned about G and values, you can have an appreciation for the difficulty a cell has in simply reversing a pathway.llosteric regulation is organized so that molecules (like ATP and citrate), which are consistent with a high energy state of the cell, turn off glycolysis. Acetyl-CoA is consistent with a high energy state, and it turns off glycolysis and turns on gluconeogenesis as well.