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Gluconeogenesis is a pivotal biochemical pathway in which glucose is synthesised from nonâcarbohydrate precursors, that is, lactate, alanine, glutamine and glycerol, during prolonged starvation.
Gluconeogenesis Pathway. Basically Gluconeogenesis is the reversal of Glycolysis which is the process of breaking down of glucose to produce energy. [ 1 ]Glycolysis proceeds to another energy cycle called Citric acid cycle by forming a substance called pyruvate.So, Gluconeogenesis is just the reversal of Glycolysis â starting with pyruvate. This removes the inhibition on the key enzyme of Gluconeogenesis and stimulates it. 2  Thus it acts as a counter hormone to insulin. 3  It causes conversion of pyruvate kinase to its inactive form by phosphorylation thus inhibiting Glycolysis and favoring Gluconeogenesis.