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It took about 2 weeks for Tiazac to work for me. I take 300 mgs with no side effects. All the literature etc. says that Diltiazem increases the effect of other bp medicines, so you might well also benefit a lot from a small dose of something else in addition.
If you have been exposed to the drug before, the rash may start quickly, within the first day or two after taking the drug. The reaction also can be delayed and not occur until 8 to 10 days after starting the drug. It is even possible to develop the rash after you have finished a one week course of medication.