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Effect of prednisone on thyroid gland morphology and plasma thyroxine and triiodothyronine concentrations in the dog. Woltz HH, Thompson FN, Kemppainen RJ, Munnell JF, Lorenz MD.
Prednisone, like all steroids, has significant side effects especially when taken long-term. It is always best to only use prednisone and other steroids for a short time if possible; however, some conditions may require long term use. Side effects of prednisone include increased appetite and weight gain.