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What areas did the Lewis and Clark expedition and the Pike expedition explore? Lewis and Clark explored the Northern part of the Louisiana Purchase, traveling up the Missouri River, and Pike explored the southern half, looking for the start of the Red River. Why were Meriwether Lewis and William Clark chosen to lead the exploration of the Louisiana Purchase? Lewis was chosen because of his experience as a leader, and Clark was chosen for his mapmaking skills.
Lewis & Clark Expedition. In 1803 President Thomas Jefferson guided a splendid piece of foreign diplomacy through the U.S. Senate: the purchase of Louisiana territory from France. After the Louisiana Purchase Treaty was made, Jefferson initiated an exploration of the newly purchased land and the territory beyond the great rock mountains in the West. He chose Meriwether Lewis to lead an expedition, who in turn solicited the help of William Clark.