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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
In most cases, testing is first done on the person with breast or ovarian cancer. If no mutation is found, the cancer was probably not due to a BRCA1/2 mutation and there is no need to test other family members. If a BRCA1/2 mutation is found, other family members can be tested for the specific mutation.o, genetic testing for BRCA1/2 mutations can affect a personâs medical care. Inherited gene mutations in some other genes (such as p53, CHEK2, ATM and PALB2) also increase breast cancer risk. Testing for some of these mutations exists.