Tay-Sachs is a disease of the central nervous system; it is a neurodegenerative disorder. Tay-Sachs most commonly affects infants. In infants, it is a progressive disease that is unfortunately always fatal. Rarely, Tay-Sachs can occur in teens and adults, causing less severe symptoms. defective gene on chromosome 15 causes Tay-Sachs disease. This defective gene causes the body to not make a protein called hexosaminidase A. Without this protein, chemicals called gangliosides build up in nerve cells in the brain, destroying brain cells.
The irritated nerves can cause significant pain. Sciatica, a painful inflammation of the sciatic nerve, is typically experienced on one side of the body, and can travel from your lower back down your leg to your feet or even toes. Sciatica is difficult to diagnose and sometimes goes away on its own.
Physical therapy can be used to soothe burning leg pain caused by overuse of muscles. Stretching may be used to relieve sciatica pain. Sciatica may cause leg and buttocks pain. Sciatica pain may be felt all the way down to the calf. Sciatica is a common cause of pain from the lower back down through the leg. Overuse of leg muscles can be the cause of burning leg pain. A bulging disc in the spine can compress the sciatic nerve and cause leg pain. If the sciatic nerve becomes irritated, it can cause pain and numbness down the leg.