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The extra gas in carbonated water creates more pressure in your stomach, increasing the chances that your stomach will regurgitate contents upward. Some carbonated waters also include natural flavorings, such as lemon or lime, which can increase acidic content, making the heartburn worse.
Serious stomach ulcers or bleeding can occur with the use of Alka-Seltzer effervescent tablets. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Alka-Seltzer effervescent tablets with food will NOT reduce the risk of these effects.