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Elderly. Initiate CYMBALTA at a dose of 30 mg once daily for 2 weeks before considering an increase to the target dose of 60 mg. Thereafter, patients may benefit from doses above 60 mg once daily. If a decision is made to increase the dose beyond 60 mg once daily, increase dose in increments of 30 mg once daily.dminister CYMBALTA at a total dose of 40 mg/day (given as 20 mg twice daily) to 60 mg/day (given either once daily or as 30 mg twice daily). For some patients, it may be desirable to start at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily.
The treatment for each of these will be somewhat different, hence the dose is different as well. The recommended Cymbalta dosage, based on the published Product Guide, are as follows: Major Depressive Disorder: Starting daily dose is 40 mg and should be taken in two separate 20 mg doses. In âmaintenance modeâ the recommended dose is 60 mg and can be taken all at once or as two separate 30 mg doses. The maximum dose, while not recommended is 120 mg/day. In fact, this high of a dose has not been thoroughly studied.