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What was the first space shuttle to go into space? STS-1 was the first space shuttle mission. During this mission, space shuttle Columbia was commanded by Capt. John W. Young and piloted by Capt. Robert L. Crippen.
Challenger flew the first American woman, African-American, Dutchman and Canadian into space; three Spacelab missions; and performed the first night launch and night landing of a Space Shuttle. Challenger was also the first space shuttle to be destroyed in an accident during a mission.