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Osteoarthritis is a joint disease that mostly affects cartilage. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage allows bones to glide over each other. It also helps absorb shock of movement.
1 The division of cells within cartilage occurs very slowly. 2  Articular cartilage function is dependent on the molecular composition of its extracellular matrix (ECM).  Remodeling of cartilage is predominantly affected by changes and rearrangements of the collagen matrix in response to forces experienced by the cartilage.