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The study began with an open-label dose optimization period (4 to 6 weeks) with an initial QUILLIVANT XR dose of 20 mg once daily in the morning. The dose could be titrated weekly in increments of 10 or 20 mg until a therapeutic dose or the maximum dose of 60 mg/day was reached.
Another dose is 1.0 mg initially, followed by 0.5 mg three times daily. To prevent gout attacks (prophylaxis) the FDA recommends 0.6 mg once or twice a day for anyone older than 16 years of age. Maximum dose: 1.2 mg a day. A 2009 study showed that hourly, or four times daily doses are not necessary.