Many scientists and doctors have linked RA to the mindbody process, which helps to clarify the possible true nature of many autoimmune disorders, including rheumatoid arthritis and other closely related conditions, like ankylosing spondylitis, lupus and gout.
Azoles are metabolized by cytochrome P-450 3A (CYP 3A) and may inhibit the elimination of other drugs metabolized by this enzyme, such as antiarrhythmics, cortisol, cyclosporin, estradiol and tacrolimus. Terbinafine is not an azole; it does not affect CYP 3A and it has few drug interactions.
In laboratory animals, no anticholinergic or alpha1-adrenergic-receptor blocking effects were observed. Moreover, no sedative or other central nervous system effects were observed. Radiolabeled tissue distribution studies in rats indicated that fexofenadine does not cross the blood-brain barrier.exofenadine hydrochloride, the major active metabolite of terfenadine, is an antihistamine with selective peripheral H 1 -receptor antagonist activity. Fexofenadine hydrochloride inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats.