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Marfan syndrome is a genetic disorder that affects the bodyâs connective tissue. Connective tissue holds all the bodyâs cells, organs and tissue together. It also plays an important role in helping the body grow and develop properly.Connective tissue is made up of proteins.The protein that plays a role in Marfan syndrome is called fibrillin-1. Marfan syndrome is caused by a defect (or mutation) in the gene that tells the body how to make fibrillin-1.This mutation results in an increase in a protein called transforming growth factor beta, or TGF-Î².he protein that plays a role in Marfan syndrome is called fibrillin-1. Marfan syndrome is caused by a defect (or mutation) in the gene that tells the body how to make fibrillin-1.
Some genetic disorders are caused by mutations in the DNA of genes. Other disorders are caused by changes in the overall structure or number of chromosomes.14 people found this useful.Edit.erge this question into. Split and merge into it. Answered by The Community. Making the world better, one answer at a time. Genetic disorders are commonly passed down or caused by mutations. In humans mutations can be caused by errors in mitosis or by mutagenic agents.