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Most cases of Angelman syndrome (about 70 percent) occur when a segment of the maternal chromosome 15 containing this gene is deleted. In other cases (about 11 percent), Angelman syndrome is caused by a mutation in the maternal copy of the UBE3A gene.In a small percentage of cases, Angelman syndrome results when a person inherits two copies of chromosome 15 from his or her father (paternal copies) instead of one copy from each parent.ost cases of Angelman syndrome are not inherited, particularly those caused by a deletion in the maternal chromosome 15 or by paternal uniparental disomy. These genetic changes occur as random events during the formation of reproductive cells (eggs and sperm) or in early embryonic development.
Each of these mutations can cause a variety of different diseases and conditions. Read on to learn what these mutations are and what disorders they can cause. slide 1 of 8. The causes of chromosomes mutation occur when there is any change in the arrangement or structure of the chromosomes.These mutations occur most often during meiosis during the stage when crossing over occurs. There are several different mutation types that result in chromosomal structure change.This change in structure leads to serious changes in an organisms' phenotype and genotype. If essential parts of the DNA are affected by chromosomal mutations, a foetus can be aborted prior to birth without the mother's control.ach of these mutations can cause a variety of different diseases and conditions. Read on to learn what these mutations are and what disorders they can cause. slide 1 of 8. The causes of chromosomes mutation occur when there is any change in the arrangement or structure of the chromosomes.