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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
For BRCA1 mutation carriers the Breast Cancer Linkage Consortium reported an increase in PrCa risk in men aged <65 years with a RR of 1.82 (95% confidence interval (CI) 1.01â3.29, P=0.05), but no risk increase was seen for men 65 years.