Pleural effusion. Pleural effusion is an abnormal buildup of fluid in the pleural cavity. The pleural cavity is the space between the lungs and the chest wall. The fluid builds up between the 2 layers of the pleura, which is a thin layer of tissue that covers the lungs and lines the chest wall. When pleural effusion is related to cancer or there are cancer cells in the fluid, it may be called malignant pleural effusion.
All three HPV vaccines should be administered in a 3-dose schedule, with the second dose administered 1 to 2 months after the first dose and the third dose 6 months after the first dose. The minimum interval between the first and second doses of vaccine is 4 weeks.
Safety of HPV vaccine during pregnancy. Currently there are 2 inactive recombinant HPV vaccines available in Canada: a quadrivalent vaccine, which provides protection against HPV types 6, 11, 16, and 18, and a bivalent vaccine, which provides protection against HPV types 16 and 18. combined analysis of 5 randomized controlled trials reported outcomes of 3620 women who, during phase 3 clinical trials, were inadvertently exposed to the quadrivalent HPV vaccine or placebo either during or just before pregnancy.