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What areas did the Lewis and Clark expedition and the Pike expedition explore? Lewis and Clark explored the Northern part of the Louisiana Purchase, traveling up the Missouri River, and Pike explored the southern half, looking for the start of the Red River. Why were Meriwether Lewis and William Clark chosen to lead the exploration of the Louisiana Purchase? Lewis was chosen because of his experience as a leader, and Clark was chosen for his mapmaking skills.
The site for the Lewis & Clark State Historic Site was chosen because it sits across from the present day mouth of the Missouri River. There were many activities that required the Corps of Discovery s attention during the winter of 1803-1804.