Many scientists and doctors have linked RA to the mindbody process, which helps to clarify the possible true nature of many autoimmune disorders, including rheumatoid arthritis and other closely related conditions, like ankylosing spondylitis, lupus and gout.
Azoles are metabolized by cytochrome P-450 3A (CYP 3A) and may inhibit the elimination of other drugs metabolized by this enzyme, such as antiarrhythmics, cortisol, cyclosporin, estradiol and tacrolimus. Terbinafine is not an azole; it does not affect CYP 3A and it has few drug interactions.
Terbinafine is increasingly used in combination with other antifungal agents to treat resistant or refractory mycoses due to synergistic in vitro antifungal activity; high doses are commonly used, but limited data are available on systemic exposure, and no assessment of pharmacodynamic target attainment has been made.