Nicotine withdrawal symptoms can actually begin as early as 30 minutes after smoking a cigarette. Depending on how long a person has been smoking, and on how heavily they smoke, the effects of nicotine on the brain generally wears off anywhere between 30 minutes and 2 hours.
Blue Harvest is the hour-long first episode of the sixth season of the FOX series Family Guy, which originally aired on September 23, 2007. It is the first part of The Laugh It Up Fuzzball Trilogy, a trio of episodes retelling and parodying the original trilogy with the show's characters recast into specific roles.
MacFarlane pitched a seven-minute pilot to Fox in 1998, and the show was greenlit and began production. Shortly after the third season of Family Guy had aired in 2002, Fox canceled the series, with one episode left unaired. Adult Swim burned off the episode in 2003, finishing the series' original run.