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If a soil test reveals that nutrients are extremely low, fertilize azaleas in the spring or fall. Use a granular, slow-release fertilizer that is acid-forming and apply a very light scattering around the edge of the root zone of the plant.f a soil test reveals that nutrients are extremely low, fertilize azaleas in the spring or fall. Use a granular, slow-release fertilizer that is acid-forming and apply a very light scattering around the edge of the root zone of the plant.
1 The best time to prune azalea bushes is right after the blooms fade. 2  If you prune any branches from your azalea bushes that appear diseased, wipe the pruning shears with diluted bleach prior to trimming the next branch. 3  This will help to prevent the spread of disease to healthy branches.