Tay-Sachs is a disease of the central nervous system; it is a neurodegenerative disorder. Tay-Sachs most commonly affects infants. In infants, it is a progressive disease that is unfortunately always fatal. Rarely, Tay-Sachs can occur in teens and adults, causing less severe symptoms. defective gene on chromosome 15 causes Tay-Sachs disease. This defective gene causes the body to not make a protein called hexosaminidase A. Without this protein, chemicals called gangliosides build up in nerve cells in the brain, destroying brain cells.
The irritated nerves can cause significant pain. Sciatica, a painful inflammation of the sciatic nerve, is typically experienced on one side of the body, and can travel from your lower back down your leg to your feet or even toes. Sciatica is difficult to diagnose and sometimes goes away on its own.
Generally, leg pain refers to any pain that develops between your feet and your pelvis. To make matters even more complicated, the cause of leg pain may not even be due to a problem with your leg. For example, some spine disorders can cause leg pain. Leg pain may be acute or chronic.