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Osteoarthritis is a joint disease that mostly affects cartilage. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage allows bones to glide over each other. It also helps absorb shock of movement.
This Review focuses on bone erosion in RA, and does not discuss cartilage damage. Nonetheless, cartilage damage is an equally important feature of structural damage in RA that occurs through fundamentally different mechanisms to bone erosions.