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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
Of the genes linked with breast cancer, BRCA1 and BRCA2 are the most well-understood. When a person is found to have a mutation in one of these genes, there are special recommendations for breast cancer screening, risk-lowering options and care.So, genetic testing for BRCA1/2 mutations can affect a personâs medical care.ost women who get breast cancer do not have an inherited gene mutation. Five to 10 percent of breast cancers in the U.S. are linked to an inherited gene mutation [ 4,35 ]. BRCA1 and BRCA2 (BReast CAncer genes 1 and 2) are the best-known genes linked to breast cancer (learn more).