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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
Other inherited gene mutations . In addition to BRCA1/2 gene mutations, other inherited gene mutations increase the risk of breast cancer. Some also increase the risk of other cancers. These gene mutations are more rare than BRCA1/2 mutations and thereâs still much to learn about them.