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Suboxone is made of two drugs-buprenorphine and naloxone. The buprenorphine is what sticks around in your system and prevents withdrawl. It has a 36 hour half-life. So if yo â¦ u took 2mg of suboxone one time only, 36 hours later you'd have 1mg left in your system. 36 hours after that you'd have .5 mg in your system.
1 Suboxone contains a secondary ingredient, Naloxone, which is a pure antagonist and this drug is there to act as a deterrent against abuse. 2  Hospitals also use Naloxone to reverse the effects of deliberate or accidental poisoning with narcotic agonists (Heroin) as well as some partial antagonists (Buprenorphine).ean off Subutex or Suboxone by doing a slow taper of 1mg to 2mg per fortnight. The withdrawals from Subutex and Suboxone are severe because of the long half-life of the drug and the withdrawal syndrome is long and drawn out.