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The prefrontal cortex is a part of the brain located at the front of the frontal lobe. It is implicated in a variety of complex behaviors, including planning, and greatly contributes to personality development.he development of the prefrontal cortex plays a significant role in maturation. The brain develops in a back to front pattern, and the prefrontal cortex is the last portion of the brain to fully develop. This does not mean that children do not have functional prefrontex cortices.
Medical Definition of PREFRONTAL CORTEX. : the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning.ADVERTISEMENT.noun. the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning.