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The study began with an open-label dose optimization period (4 to 6 weeks) with an initial QUILLIVANT XR dose of 20 mg once daily in the morning. The dose could be titrated weekly in increments of 10 or 20 mg until a therapeutic dose or the maximum dose of 60 mg/day was reached.
SIMPLICITY. Febuxostat is available in 40-mg and 80-mg tablets. The initial dosage is 40 mg once per day, increasing to 80 mg once per day if serum uric acid levels remain at 6 mg per dL or higher after two weeks of therapy. Dosage adjustments are unnecessary for mild to moderate renal or hepatic impairment.IMPLICITY. Febuxostat is available in 40-mg and 80-mg tablets. The initial dosage is 40 mg once per day, increasing to 80 mg once per day if serum uric acid levels remain at 6 mg per dL or higher after two weeks of therapy. Dosage adjustments are unnecessary for mild to moderate renal or hepatic impairment.