Without enough thyroid hormone, metabolism slows, making weight gain more likely. Even a thyroid functioning at the lower end of the normal range might cause weight gain. Treating hypothyroidism with medication may reverse some of the weight gain. If you have any concerns, seek medical advice.
1 Allele: a different version of a gene. 2  Dominant: a trait that is visible and can cover up other traits when there is more than one present. 3  Genotype: the genetic makeup of an organism, or the versions of a gene that an organism has. 4  Heterozygous: having two different versions of a gene.
A genetic predisposition (sometimes also called genetic susceptibility) is an increased likelihood of developing a particular disease based on a personâs genetic makeup. A genetic predisposition results from specific genetic variations that are often inherited from a parent.lthough a personâs genetic makeup cannot be altered, some lifestyle and environmental modifications (such as having more frequent disease screenings and maintaining a healthy weight) may be able to reduce disease risk in people with a genetic predisposition.