Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Density Dependent Limiting Factors. The density dependent factors are factors whose effects on the size or growth of the population vary with the population density. There are many types of density dependent limiting factors such as; availability of food, predation, disease, and migration. However the main factor is the availability of food.