Head and neck lymphedema can be caused by surgery or radiation therapy for tongue or throat cancer. It may also occur in the lower limbs or groin after surgery for colon, ovarian or uterine cancer, in which removal of lymph nodes or radiation therapy is required.
1 Heart attack. A heart attack can damage the area of the heart muscle that supports the mitral valve, affecting the function of the valve. If the damage is extensive enough, a heart attack can cause sudden and severe mitral valve regurgitation.  Abnormality of the heart muscle (cardiomyopathy).
Mitral regurgitation or mitral insufficiency is a condition in which the mitral valve does not close completely, so it allows blood to flow backward from the left ventricle into the left atrium.atients with mild mitral regurgitation do quite well. In cases of more severe mitral regurgitation, the left heart may grow larger as it needs to accommodate a larger volume of blood, and the patient may eventually become fatigue or weak.