Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Population control may involve culling, translocation, or manipulation of the reproductive capability. The growth of a population may be limited by environmental factors such as food supply or predation. The main biotic factors that affect population growth include: Food â both the quantity and the quality of food are important.