Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Limitations to population growth are either density-dependant or density-independent. Density-dependent factors include disease, competition, and predation. Density-dependant factors can have either a positive or a negative correlation to population size. With a positive relationship, these limiting factors increase with the size of the population and limit growth as population size increases.