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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
Location. The sciatic nerve is the largest single nerve in the body. It begins in the lower part of the back and runs through the hip/buttock region, giving off two branches; the articular branch, which provides nerve function to the hip-joint, and the muscular branch, which extends into the muscles of the thigh.