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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
The sciatic nerve is one of the longest nerves in the human body. At its thickest point, it can measure the width of a thumb. This nerve starts at the backâs lumbar region and continues all the way down the back of the legs, ending at the toes. The sciatic nerve is made up of two different branches, one branch for each side of the spine.