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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
Sciatic Nerve and Pain. Sciatica is the term for nerve pain that comes from the sciatic nerve, the longest and widest nerve of the body. There are two sciatic nerves that come from each side of the spine where the low back meets the buttocks. The sciatic nerve travels down the back of each leg to the foot.