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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
The sciatic nerve is the dominant nerve that innervates the lower back and the lower extremities. It travels from the lower spine, through the pelvis, and down each leg. It is the longest and widest nerve in the human body.