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Idiopathic pulmonary fibrosis (IPF) causes scar tissue to grow inside your lungs. Usually, when you breathe in, oxygen moves through tiny air sacs into your bloodstream. From there, it travels to organs in your body. IPF scar tissue is thick, like the scars you get on your skin after a cut.
In the PLCO trial, pulmonary scarring was associated with increased lung cancer risk but only for cancer in the same lung where scarring was present, suggesting that scarring is associated with a localized process of tissue damage and repair that may contribute to cancer development.