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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
Sciatic nerve â The sciatic nerve is the largest single nerve in the body, extending from the back of the pelvis down the back of the thigh. It is the primary nerve of the leg and is responsible for innervating the muscles in the hip and lower limbs (including the tibial nerve and common fibular nerve).