lose - allow to go out of sight; The detective lost the man he was shadowing after he had to stop at a red light 7. lose - fail to make money in a business; make a loss or fail to profit; I lost thousands of dollars on that bad investment!; The company turned a loss after the first year turn a loss break even - make neither profit nor loss
Melancholy is a state of being sad, gloomy, or even pensive. When there is something weighing on your mind, you can become quiet and withdrawn, preferring to be with your own thoughts in order to make some sense of what is going on.
Depression is an illness that involves the body, mood, and thoughts. It interferes with daily life, normal functioning, and causes pain for both the person with the disorder and those who care about him. A depressive disorder is not the same as a passing blue mood. It is not a sign of personal weakness or a condition that can be willed or wished away. People with a depression cannot merely pull themselves together and get better. Depression, even in the most severe cases, is highly treatable.