I. Introduction. 1  The petroleum industry began with the successful drilling of the first commercial oil well in 1859, and the opening of the first refinery two years later to process the crude into kerosene.
The cause of Down syndrome is one of three types of abnormal cell division involving chromosome 21. All three abnormalities result in extra genetic material from chromosome 21, which is responsible for the characteristic features and developmental problems of Down syndrome.
This type of Down syndrome, which accounts for 95% of cases, is called trisomy 21. Down syndrome is usually caused by an error in cell division called nondisjunction.. Nondisjunction results in an embryo with three copies of chromosome 21 instead of the usual two. Prior to or at conception, a pair of 21st chromosomes in either the sperm or the egg fails to separate.