Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
In the context of populations, a limiting factor is a factor that causes population growth to decrease. Density-Dependent Factors Density-Dependent Factors A limiting factor that depends on population size is called a density-dependent limiting factor. Density-Dependent Factors Density-dependent limiting factors include: â¢ competition â¢ predation â¢ parasitism â¢ disease Density-Dependent Factors Density-dependent factors operate only when the population density reaches a certain level. These factors operate most strongly when a population is large and dense. They do not affect small, scattered populations as greatly. Density-Dependent Factors Competition When populations become crowded, organisms compete for food, water space, sunlight and other essentials. Competition among members of the same species is a density-dependent limiting factor. Density ...