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Cholecystokinin definition, a hormone secreted by the upper portion of the intestine that stimulates contraction of the gallbladder and increases secretion of pancreatic juice. See more. Dictionary.com
Cholecystokinin (CCK) is released in the duodenum in response to high-fat or high-protein meals. It signals the brain to produce a sense of fullness or satiety. Fatty meals are an especially effective trigger in the release of CCK.