ICH overview. 1  Guidelines for the investigator. 2  Guidelines for the trial sponsor (industrial, academic) 3  Guidelines for the clinical trial protocol and protocol amendments. 4  Guidelines for the Investigator's brochure.
A mark or sign made by an individual on an instrument or document to signify knowledge, approval, acceptance, or obligation. The term signature is generally understood to mean the signing of a written document with one's own hand. However, it is not critical that a signature actually be written by hand for it to be legally valid. It may, for example, be typewritten, engraved, or stamped.
(ËsÉªÉ¡nÉªtÊÉ) n. 1. the name of a person or a mark or sign representing his name, marked by himself or by an authorized deputy. 2. the act of signing one's name. 3. a. a distinctive mark, characteristic, etc, that identifies a person or thing. b. (as modifier): a signature fragrance.