The placenta is a fetomaternal organ. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell.
A patient who misses a dose of BRILINTA should take one tablet (the next dose) at its scheduled time 1 BRILINTA is metabolized by the liver and impaired hepatic function can increase risks for bleeding and other adverse events.
Concomitant Aspirin Maintenance Dose. In PLATO the use of BRILINTA with maintenance doses of aspirin above 100 mg decreased the effectiveness of BRILINTA. Therefore, after the initial loading dose of aspirin, use BRILINTA with a maintenance dose of aspirin of 75-100 mg [see Dosage and Administration (2.1) and Clinical Studies (14.1)]. Dyspnea In clinical trials, about 14% of patients treated with BRILINTA developed dyspnea.