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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
Sciatica. The sciatic nerve runs from the spinal cord to the hips and buttocks and down the back of each leg. So, sciatica may manifest as lower back, hip, or leg pain along the sciatic nerve pathway.