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The Plague of Justinian (AD 541â542) was a pandemic that afflicted the Eastern Roman Empire, including its capital Constantinople. At its peak, 5,000 people per day in Constantinople died from it, killing half the population. From there, the plague moved east and west, becoming antiquity's most lethal known pandemic.
This article is about the historiography of the decline of the Roman Empire. For a description of events, see Fall of the Western Roman Empire. For the historical era in general, see Late Antiquity. For the book by Edward Gibbon, see The History of the Decline and Fall of the Roman Empire. The causes and mechanisms of the fall of the Western Roman Empire are a historical theme that was introduced by historian Edward Gibbon in his 1776 book The Decline and Fall of the Roman Empire.