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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
The sciatic nerve. The sciatic nerve begins in the lumbar (lower back) region of the spine, specifically at the L4 and L5 levels. The nerve exits the spinal canal through two openings in the sacral (pelvic) spine, extending through the length of the legs. The sciatic nerve is the widest nerve of all the millions in the body, and it is also the longest nerve, which means it innervates more areas than any other nerve. Since the sciatic nerve begins in the lower back, but travels all the way to the toes, sciatic nerve pain can extend to the following areas: