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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
1 Sciatic nerve â The sciatic nerve is the largest single nerve in the body, extending from the back of the pelvis down the back of the thigh. 2  It is the primary nerve of the leg and is responsible for innervating the muscles in the hip and lower limbs (including the tibial nerve and common fibular nerve).