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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
The sciatic nerve is the largest and longest nerve in the body. It runs from the lower back region through the buttock and continues down the back of the leg. The sciatic nerve controls the movement of many muscles in the thigh and leg as well as provides a means of sensory input to the brain.