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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
Video Transcript. The sciatic nerve is the longest and largest nerve in the human body, running from the lower back through the back of the leg, and down to the toes. The sciatic nerve starts as a collection of nerve fibers in the lower spine.ideo Transcript. The sciatic nerve is the longest and largest nerve in the human body, running from the lower back through the back of the leg, and down to the toes. The sciatic nerve starts as a collection of nerve fibers in the lower spine.