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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
Sciatic nerve symptoms always occur in the lower back where the nerve takes shape. The. sciatic nerve is actually made up of five nerves that come out of the right and left hand. side of the lower spine. You have a curve in your lower spine, and this area is referred to. as the lumbar spine.