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Definition: Tailing factor. The tailing factor is a measure of peak tailing. It is defined as the distance from the front slope of the peak to the back slope divided by twice the distance from the center line of the peak to the front slope, with all measurements made at 5% of the maximum peak height.t is defined as the distance from the front slope of the peak to the back slope divided by twice the distance from the center line of the peak to the front slope, with all measurements made at 5% of the maximum peak height.
It is easyto see that a minor peak could hide underthe peak tail and that ICH requirements forminor peaks might not be met if severepeak tailing occurred.LC methods used for routine analysismust usually provide baseline resolution of all the peaks and run times that are asshort as possible.or all the peaksshown, the start of the peak is the same,and it is easy for the data system todetermine when the peak starts. The morethe peak tails, the more gradual the returnto baseline. In addition, the end of thepeak is difficult to determine, especially ifthe baseline is not smooth.