Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Some factors include: small populations; predation by introduced species; competition with other organisms; the destruction of their habitats by other animals or humans; being hunted for their skin, fur, feathers or other body parts and living in specialised habitats and relying on particular foods.