Any person or entity interested in a particular business is called a stakeholder. They are affected by the business activity, and they may be part of the core decision-making team. Internal and external stakeholders may have different interests and priorities, possibly leading to conflicts of interest.
Raynaud's disease refers to a disorder in which the fingers or toes (digits) suddenly experience decreased blood circulation. It is characterized by repeated episodes of color changes of the skin of digits on cold exposure or emotional stress.
Patients with Secondary Raynaud's can also have symptoms related to their underlying diseases. Raynaud's phenomenon is the initial symptom that presents for 70% of patients with scleroderma, a skin and joint disease. When Raynaud's phenomenon is limited to one hand or one foot, it is referred to as Unilateral Raynaud's.This is an uncommon form, and it is always secondary to local or regional vascular disease.aynaud's disease, or Primary Raynaud's, is diagnosed if the symptoms are idiopathic, that is, if they occur by themselves and not in association with other diseases. Some refer to Primary Raynaud's disease as being allergic to coldness. It often develops in young women in their teens and early adulthood.