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1 Use common sense: If it upsets your stomach when you eat it, avoid it. Everyone is different, but spicy foods, citrus fruits, and fatty foods are common irritants.  Stop smoking. Heavy smokers are more likely to develop duodenal ulcers than nonsmokers.
Tips to prevent mouth ulcers. You can take steps to reduce the occurrence of mouth ulcers. Avoiding foods that irritate your mouth can be helpful. That includes acidic fruits like pineapple, grapefruit, oranges, or lemon, as well as nuts, chips, or anything spicy.