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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
The sciatic nerve systems are located in in the lumbar and the sacral regions of the spine. Sciatic pain or sciatica can be described as sharp, dull, burning, tingly, numb, continuous, or intermittant and usually affects only one side of the body. It can radiate the entire length of the nerve, in some cases all the way down to the toes.