Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
In the natural world, limiting factors like the availability of food, water, shelter and space can change animal and plant populations. Other limiting factors, like competition for resources, predation and disease can also impact populations. If any of the limiting factors change, animal and plant populations change, too. Some changes may cause a population to increase.