Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Biotic and abiotic factors affect the organisms in an ecosystem. Biotic factors may include things like predation, disease, competition, parasitism, consumption, and symbiosis. And certainly abiotic factors, like the weather, can also impact living things.