Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
This is a limiting factor because plants and animals die from this type of natural disaster if populations do not move far enough away from the mountain. Density dependent factors are different in that the size of populations affect how certain factors increase or decrease numbers of specimens. Predation, disease and competition for resources affect populations based on their size.