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Celiac disease is an uncommon disease in which your immune system attacks the cells lining the small intestine. Signs and symptoms of celiac disease may include: 1  diarrhea, 2  bloating, 3  gas (flatulence, farting),  swollen ankles (edema),
10 Symptoms of Celiac Disease: Do You Have It? Celiac disease, also known as coeliac disease, is an autoimmune disorder that affects around 1 in 100 Americans. The disease is caused by gluten intolerance. Gliadin, a protein in wheat, causes the afflicted persons immune system to attack its own bowel tissue. This causes villous atrophy, or the erosion of the nutrient absorbing villi that line the small intestine.