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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
The sciatic nerve is the largest and longest spinal nerve in the human body. Extending from the lumbar and sacral plexuses in the lower back, the sciatic nerve runs through the buttocks and into the thighs. It delivers nerve signals to and from the muscles and skin of the thighs, lower legs and feet.