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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
The sciatic nerve is the primary nerve that runs down the back of the leg. It branches from the lower spine and runs the entire length of the leg and foot. What is the anatomy of a sciatic nerve? Five spinal nerve roots come together to make up the sciatic nerve, the largest nerve in the human body.