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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
Your sciatic nerve begins at your spinal cord, runs through your hips and buttocks, and then branches down each leg. This nerve is your bodyâs longest nerve and one of the most important ones. It has a direct effect on your ability to control and feel your legs. When this nerve is irritated, youâll experience sciatica.