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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
The sciatic nerve is the dominant nerve that innervates the lower back and the lower extremities. It travels from the lower spine, through the pelvis, and down each leg. It is the longest and widest nerve in the human body. The sciatic nerve primarily supplies the muscles of the lower leg, including the calf, ankle, and the back portion of the knee. It also supplies sensation to the sole of the foot, the ankle, the entire lower leg, and the back of the thigh. The sciatic nerve branches into different parts of the body along its path, hence its ability to supply such a large area of the body.