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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
There is another situation, in which dialysis is badly needed, that is when your BUN level is higher than 54mol/l or the creatinine level is up to 884ummol/l. Timely and adequate dialysis is necessary for patients to live a better life. It can lower high BUN and creatinine level.