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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
While ghrelin is an appetite-stimulating peptide, leptin is an appetite-suppressing one. Ghrelin, secreted from the stomach, particularly influences the metabolism of fat tissue by promoting its storage during hard times. Leptin and ghrelin function interdependently in healthy humans.