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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
Other conditions that cause BUN-to-creatinine ratio to rise are kidney disease, kidney stones, or bleeding in the intestines. Low BUN-to-creatinine can occur in pregnancy, liver disease, or a diet low in protein. The BUN-to-creatinine ratio is not a precise or reliable test, though. It may often be somewhat abnormal in healthy people. More important is the creatinine level itself; if itâs elevated, the kidneys are not working properly, and the reason should be sought out.