What physicians need to know about restrictive covenants. Roy W. BreitenbachThe mention of restrictive covenants provokes an almost visceral reaction among most physicians. But keep in mind these covenants are, for the most part, enforceable.
An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. medicinal enzyme inhibitor is often judged by its specificity (its lack of binding to other proteins) and its potency (its dissociation constant, which indicates the concentration needed to inhibit the enzyme). A high specificity and potency ensure that a drug will have few side effects and thus low toxicity.
The inhibitor chemicallyresembles a (one of the) substrate(s) and binds in the active site in the same way as thesubstrate(s) binds. The inhibitor, however, has a functional group, ususally a leaving group,that is replaced by a nucleophile in the enzyme active site.herefore thistype of inhibition is called suicide inhibition or affinity labeling and the inhibitor is called a suicide inhibitor. This reaction with the suicide inhibitor removes active enzyme from the system; this removal is measured as inhibition.