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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
Kidney Tests. A high BUN level may indicate kidney diseases, such as glomerulonephritis or kidney failure. Other possible causes include congestive heart failure or hypovolemic shock. A low BUN level may point to liver problems, insufficient protein in your diet, or drinking too much water.