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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
Higher levels may be a sign that the kidneys are not working properly. As kidney disease progresses, the level of creatinine in the blood increases. Blood Urea Nitrogen (BUN). Urea nitrogen (yoo-REE-uh NY-truh-jen) also is produced from the breakdown of food protein. A normal BUN level is between 7 and 20 mg/dl.