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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
How Do Villi Increase Surface Area? One way to visualize how villi increase surface area is to compare your intestinal lining to a piece of ribbon. If you stretch the ribbon out and lay it flat in a space between your fingers, you can fit far less of it in that space than if you bunched it up and laid it down in a wavy pattern.