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Wiktionary (0.00 / 0 votes) Rate this definition: disease (Noun). An abnormal condition of the body or mind that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired. The tomato plants had some kind of disease that left their leaves splotchy and fruit withered. disease (Noun). Any abnormal or harmful condition, as of society, people's attitudes, way of living etc. disease (Verb). To cause unease; to annoy, irritate. disease (Verb). To infect with a disease.
A disease is an abnormal condition affecting the body of an organism. It is often construed to be a medical condition associated with specific symptoms and signs. It may be ca â¦ used by external factors, such as infectious disease, or it may be caused by internal dysfunctions, such as autoimmune diseases.