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Freebase(0.00 / 0 votes)Rate this definition: OSIsoft. OSIsoft, LLC is a worldwide manufacturer of Application software for real-time data infrastructure solutions, called the PI System. Founded in 1980, OSIsoft, LLC is privately held and headquartered in San Leandro, CA, with operations worldwide.
In the Open Systems Interconnection (OSI) communications model, the Network layer knows the address of the neighboring nodes in the network, packages output with the correct network address information, selects routes and quality of service, and recognizes and forwards to the Transport layer incoming messages for local host domains.