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Author: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand,1999. Exfoliative keratolysis is a common skin condition in which there is focal peeling of the palms and less often the soles. It is also known as âkeratolysis exfoliativaâ, dyshidrosis lamellosa sicca, and âfocal palmar peelingâ.
Immune System Disorders. Schleroderma and psoriasis are two of the many autoimmune disorders that can cause skin peeling on fingers and hands. These conditions are only some of the possible medical conditions that can cause this symptom. A condition called Kawasaki disease can also cause skin to peel on the hands. This condition most commonly affects only children age five and younger. Fungal infections and allergic reactions are common causes of skin that itches and peels.