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lose - allow to go out of sight; The detective lost the man he was shadowing after he had to stop at a red light 7. lose - fail to make money in a business; make a loss or fail to profit; I lost thousands of dollars on that bad investment!; The company turned a loss after the first year turn a loss break even - make neither profit nor loss
Wiktionary(5.00 / 1 vote)Rate this definition: 1  loss(Noun) an instance of losing, such as a defeat. The match ended in their first loss of the season. 2  loss(Noun) something that is lost. It was written off as a loss. 3  loss(Noun) the hurtful condition of having lost something or someone. We mourn his loss.