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NSAIDs. Nonsteroidal anti-inflammatory drugs work to help treat the symptoms of gout as well as other forms of arthritis. Over-the-counter NSAIDs such as naproxen sodium and prescription-level medications such as indomethacin can reduce the pain and swelling of a gout attack.
Colchicine (Colcrys, Mitigare): This prescription pain reliever can stop a gout flare at the first sign of an attack. Low doses of the drug are well-tolerated, but higher doses may cause side effects such as nausea, vomiting, and diarrhea. Corticosteroids: Prednisone is the most commonly prescribed corticosteroid.