Heart problems can cause sensations in other areas of the body besides your chest. Symptoms can include discomfort, pain, or pressure in the arms, back, neck, jaw, or stomach.
Infection with feline infectious peritonitis virus (FIPV), a feline coronavirus, frequently leads to death in spite of a strong humoral immune response. In previous work, we reported that infected monocytes, the in vivo target cells of FIPV, express viral proteins in their plasma membranes.These proteins are quickly internalized upon binding of antibodies.hese findings indicate that the viral antigen-antibody complexes were not internalized through any of the previously described pathways. Further characterization showed that this internalization process was independent from phosphatases and tyrosine kinases but did depend on serine/threonine kinases.
Monocytes are a type of white blood cell which circulate in the blood. The CAE virus cannot replicate inside a monocyte but its genome (called a provirus) is carried to all tissues of the body without being detected by the immune system.When a monocyte migrates to body tissues it matures into a macrophage.he CAE virus will know that it is near a monocyte or macrophage because the envelope protein on the surface of the virus will fit only with a cell surface protein that exists only on goat (and sheep) monocyte/ macrophage cells.