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If you do develop a flare-up of gout while taking allopurinol, continue taking the medication while your doctor prescribes additional treatment to settle the attack. Although allopurinol is taken without any side effects in most patients, around 10% do experience problems. A skin rash is the most common side effect.
Medications for Treating An Acute Gout Attack. Here are the medications used to treat an acute gout attack. Nonsteroidal anti-inflammatory drugs (NSAIDs) NSAIDs are frequently used to quickly relieve the pain and swelling of an acute gout episode and can shorten the attack, especially if taken in the first 24 hours.