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If you do develop a flare-up of gout while taking allopurinol, continue taking the medication while your doctor prescribes additional treatment to settle the attack. Although allopurinol is taken without any side effects in most patients, around 10% do experience problems. A skin rash is the most common side effect.
1 Colchicine, to prevent flare-ups during the first months that you are taking medicines that lower uric acid.  Pegloticase (Krystexxa). This medicine is for gout that has lasted a long time and hasn't responded to other treatment.