Remember, your problem statement is the backbone of the proposal and the feasibility report. By giving careful consideration to how you construct it now (for the proposal), you can use it when doing your research and writing for the proposal as well as the progress and the feasibility report.
http://www.ohsu.edu/research/skachlab/an... follow this link and it will take to a page where it describe very clearly the sequences of event that occurs during translocation. animated clips are also included which i believed will allow you to understand the process more clearly.
The most common type of unbalanced translocation is translocation Down syndrome. Translocation Down syndrome produces the same symptoms and physical characteristics of regular Down syndrome. In the translocation type of Down syndrome, the child has three copies of the long arm of chromosome 21 instead of two.