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The major target end organs for parathyroid hormone (PTH) action are the kidneys, skeletal system, and intestine. The primary response to parathyroid hormone (PTH) by the kidney is to increase renal calcium resorption and phosphate excretion.
Normally, PTH increases when the level of calcium in your blood falls and decreases when your calcium level rises. Your body also makes calcitonin when your calcium level gets too high. When you have hypercalcemia, your body is unable to regulate your calcium level as it normally would.