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lose - allow to go out of sight; The detective lost the man he was shadowing after he had to stop at a red light 7. lose - fail to make money in a business; make a loss or fail to profit; I lost thousands of dollars on that bad investment!; The company turned a loss after the first year turn a loss break even - make neither profit nor loss
Define loss. loss synonyms, loss pronunciation, loss translation, English dictionary definition of loss. n. 1. The act or an instance of losing: nine losses during the football season. 2. a. One that is lost: wrote their flooded house off as a loss. b.