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Relative abundances of phosphoglycerides and sphingolipids differ between membranes of ER and Golgi. Phospholipids synthesized in ER and sphingolipids synthesized in Golgi. Proportion of sphingomyelin as a percentage of total membrane lipid phosphorous is about six times as high in the Golgi membranes.
The pathway for fatty acid synthesis occurs in the cytoplasm, whereas, oxidation occurs in the mitochondria. The other major difference is the use of nucleotide co-factors. Oxidation of fats involves the reduction of FADH + and NAD + .Synthesis of fats involves the oxidation of NADPH.he intracellular levels of malonyl-CoA represent a balance between its synthesis from acetyl-CoA by ACC and its utilization in fatty acid synthesis by FAS as well as by its degradation to acetyl-CoA via the action of malonyl-CoA decarboxylase (MCD).