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NSAIDs. Nonsteroidal anti-inflammatory drugs work to help treat the symptoms of gout as well as other forms of arthritis. Over-the-counter NSAIDs such as naproxen sodium and prescription-level medications such as indomethacin can reduce the pain and swelling of a gout attack.
Gout may be caused by some medical drugs, such as: 1  Diuretics (water tablets). 2  Some drugs such as ACE inhibitors or beta blockers used to treat hypertension also increase risk of gout. 3  Niacin which is used to lower cholesterol level. 4  Aspirin which is used to treat abnormal blood clots. 5  Some cancer medicines.