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Author: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand,1999. Exfoliative keratolysis is a common skin condition in which there is focal peeling of the palms and less often the soles. It is also known as âkeratolysis exfoliativaâ, dyshidrosis lamellosa sicca, and âfocal palmar peelingâ.
Quick Answer. Peeling hands can be caused by hand dermatitis, psoriasis, exfoliative keratolysis and dyshidrotic eczema. Mayo Clinic explains that peeling skin commonly results from exposure to environmental elements, such as sun, wind, heat, dryness or excessive humidity. Allergic reactions to irritants such as certain fabrics, latex, detergents, foods or cosmetics can cause hands to peel.