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Symptoms and Causes of Moon Facies. Moon facies may cause the face to gradually become round, full, or puffy. The sides of your face may become so round from the buildup of fat that the ears can't be seen from the front of your face. Fat deposits in the sides of the skull can also make the face look rounder.
Finally, some drugs can cause face swelling, including commonly used medications like aspirin, penicillin, prednisone, and the substance inside asthma inhalers. Some diseases can result in swelling in the face, even when it does not seem like the face should be affected by the medical condition at all. For example, kidney disease may cause this issue, as a malfunctioning kidney can fill the body with fluids, though this is usually also accompanied by swollen hands and feet.