Remember, your problem statement is the backbone of the proposal and the feasibility report. By giving careful consideration to how you construct it now (for the proposal), you can use it when doing your research and writing for the proposal as well as the progress and the feasibility report.
http://www.ohsu.edu/research/skachlab/an... follow this link and it will take to a page where it describe very clearly the sequences of event that occurs during translocation. animated clips are also included which i believed will allow you to understand the process more clearly.
In translocation Down syndrome, the extra 21 chromosome may be attached to the #14 chromosome, or to other chromosome numbers like 13, 15, or 22.henever a translocation is found in a child, the parents' chromosomes are studied to determine whether the translocation was inherited or not. If one parent has the translocation chromosome, then the doctor knows the baby inherited the translocation from that parent.