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If you do develop a flare-up of gout while taking allopurinol, continue taking the medication while your doctor prescribes additional treatment to settle the attack. Although allopurinol is taken without any side effects in most patients, around 10% do experience problems. A skin rash is the most common side effect.
Colchicine (Colcrys, Mitigare): This prescription pain reliever can stop a gout flare at the first sign of an attack. Low doses of the drug are well-tolerated, but higher doses may cause side effects such as nausea, vomiting, and diarrhea. Corticosteroids: Prednisone is the most commonly prescribed corticosteroid.