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Quick Answer. Hand, foot and mouth disease in adults is caused by transmission from a person infected with the Coxsackievirus, according to Mayo Clinic. The virus is transmitted by personal contact such as exposure to nasal secretions, saliva, fluid from blisters, throat discharge or stool of an infected individual. Keep Learning.
Other things to know about hand, foot, and mouth disease include that: 1  HFMD is usually caused by the coxsackievirus A16 virus, although other enteroviruses can cause this type of infection. 2  Coxsackievirus A6 has been causing more severe and atypical cases of HFMD in the United Sates since 2007, including in adults.