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NSAIDs. Nonsteroidal anti-inflammatory drugs work to help treat the symptoms of gout as well as other forms of arthritis. Over-the-counter NSAIDs such as naproxen sodium and prescription-level medications such as indomethacin can reduce the pain and swelling of a gout attack.
These medicines may include: 1  Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, indomethacin, or naproxen. 2  Colchicine. 3  Corticosteroids, which may be given in pills or as a shot for cases of gout that don't respond to NSAIDs or colchicines.his can reduce how often you have gout attacks and how severe they are. These medicines may include: 1  Uricosuric agents, to increase elimination of uric acid by the kidneys. 2  Xanthine oxidase inhibitors, to decrease production of uric acid by the body.