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The major target end organs for parathyroid hormone (PTH) action are the kidneys, skeletal system, and intestine. The primary response to parathyroid hormone (PTH) by the kidney is to increase renal calcium resorption and phosphate excretion.
PTH promotes the release of calcium from bones into the bloodstream. It stimulates the kidneys to convert vitamin D from the inactive to the active form, which in turn increases the absorption of calcium from food in the intestines. It acts on the kidneys to suppress the excretion of calcium in the urine while encouraging excretion of phosphorus.