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NSAIDs. Nonsteroidal anti-inflammatory drugs work to help treat the symptoms of gout as well as other forms of arthritis. Over-the-counter NSAIDs such as naproxen sodium and prescription-level medications such as indomethacin can reduce the pain and swelling of a gout attack.
Salicylate, which is a main ingredient of aspirin and other analgesics, can also trigger an attack of gout. Even though these medications are often used in the treatment of gout pain, they can sometimes interfere with the kidney's ability to eliminate uric acid and thus may trigger more gout attacks.