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NSAIDs. Nonsteroidal anti-inflammatory drugs work to help treat the symptoms of gout as well as other forms of arthritis. Over-the-counter NSAIDs such as naproxen sodium and prescription-level medications such as indomethacin can reduce the pain and swelling of a gout attack.
Other medicines can also increase uric acid level and raise the risk of gout. These include: 1  Aspirin -- low doses reduce uric acid excretion and increase the chance of hyperuricemia. 2  This may be a problem for older people who take low-dose aspirin to protect against heart disease.