E. coli bacteria often carry multiple drug-resistance plasmids, and under stress, readily transfer those plasmids to other species. Indeed, E. coli is a frequent member of biofilms, where many species of bacteria exist in close proximity to each other. This mixing of species allows E. coli strains that are piliated to accept and transfer plasmids from and to other bacteria. Thus, E. coli and the other enterobacteria are important reservoirs of transferable antibiotic resistance. [46]
The Budweiser Clydesdales made their first-ever appearance on April 7, 1933. A gift from August A. Busch, Jr. and Adolphus Busch to their father in celebration of the repeal of Prohibition, the presentation of the original two six-horse hitches of champion Clydesdales moved father, sons and drivers to tears.
Adolphus joined the company as a salesman and proceeded to completely change the direction of the business. Budweiser was first launched in 1876, formulated to appeal to all tastes. In 1879, the brewery's name was changed from the Bavarian Brewery to the Anheuser-Busch Brewing Association, and Adolphus Busch became president the following year.