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To treat pain or menstrual cramps the normal dosage of Naproxen is 500 mg, changed with that of 250 mg every six to eight hours, according to the intensity of your pain.
1 For naproxen controlled-release tablet (e.g., NaprelanÂ®) dosage form: 2  For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 3  AdultsâAt first, 750 milligrams (mg) (taken as one 750 mg or two 375 mg tablets) or 1000 mg (taken as two 500 mg tablets) once a day. Adultsâ550 milligrams (mg) for the first dose, then 550 mg every 12 hours or 275 mg every 6 to 8 hours as needed. 2  Your doctor may increase the dose, if necessary, up to a total of 1375 mg per day. 3  ChildrenâUse and dose must be determined by your doctor.