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The immunoassay detected the 14-3-3 protein in cerebrospinal fluid from 68 of the 71 patients with CreutzfeldtâJakob disease (96 percent; 95 percent confidence interval, 92 to 99 percent). Among 94 patients with other dementias, the specificity was 96 percent.
High sensitivity and specificity of the C6-peptide ELISA on cerebrospinal fluid in Lyme neuroborreliosis patients. Clin Microbiol Infect. 2011 Jan 17. doi: 10.1111/j.1469-0691.2011.03459.x. [Epub ahead of print] Golightly MG, Thomas JA, Viciana AL.n their recent study these researchers found that indirect immunofluorescence assay (IIFA) and immunoblot (Western blot) tests produced positive results for both IgG and IgM antibodies but the ELISA tests only returned positive or borderline results in 53.3% of the patients with suspected Lyme disease.