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Causes of Celiac Disease. Celiac disease is a condition that damages the digestive tract (specifically the small intestine), causing problems with absorption of vital vitamins, minerals, and nutrients. This damage occurs when a person consumes gluten, a substance found in grains such as wheat, barley, and rye.
The exact cause of celiac disease is unknown. The lining of the intestines have small areas called villi which project outward into the opening of the intestine. These structures help absorb nutrients. When people with celiac disease eat foods with gluten, their immune system reacts by damaging the villi.