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The major target end organs for parathyroid hormone (PTH) action are the kidneys, skeletal system, and intestine. The primary response to parathyroid hormone (PTH) by the kidney is to increase renal calcium resorption and phosphate excretion.
PTH regulates levels of calcium in the blood, release of calcium from bone, absorption of calcium in the intestine, and excretion of calcium in the urine. If one or more of the parathyroid glands secretes too much hormone, as happens in primary hyperparathyroidism, the balance is disrupted: blood calcium rises.