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Medical Definition of Sharpey's fiber. : any of the thready processes of the periosteum that penetrate the tissue of the superficial lamellae of bones.
Sharpey's fibers: penetrating connective tissue fibers by which the tooth is attached to the adjacent alveolar bone; the fiber bundles penetrate cementum on one side and alveolar bone on the other. Stippling: the pitted, orange-peel appearance frequently seen on the surface of the attached gingiva.