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Author: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand,1999. Exfoliative keratolysis is a common skin condition in which there is focal peeling of the palms and less often the soles. It is also known as âkeratolysis exfoliativaâ, dyshidrosis lamellosa sicca, and âfocal palmar peelingâ.
What Causes Peeling Palms. 1  The peeling of palms is associated with several symptoms including dryness, redness, rashes, burning sensation, pain, and itchiness. There are many reasons why the palmar skin peels off, and a few of these are disorders such as: 2  Exfoliative keratolysis. Also called focal palm peeling, the exfoliative keratolysis is a condition of severe peeling of palmar skin, preceded by an outburst of air-filled blisters throughout the palms and fingers. The blisters, which may be caused by eczema, also cause the palm to peel off. Hand dermatitis.