3. Pathways to an initiated cell. Initiation involves a change in the DNA sequence or quantity, i.e. either a gene mutation, chromosome mutation (breaks, rearrangements), or genome mutation (change in the number of chromosomes). Different pathways may result in these types of changes (Fig. 3).
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Opioid Withdrawal Symptoms. The amount and severity of the withdrawal symptoms from Percocet and OxyContin depend on the amount the user took, the length of time he took the drug, the method of ingestion, and the severity of dependence.