The term cellulitis is commonly used to indicate a nonnecrotizing inflammation of the skin and subcutaneous tissues, a process usually related to acute infection that does not involve the fascia or muscles. Cellulitis is characterized by localized pain, swelling, tenderness, erythema, and warmth.
The regions on chromosomes 7 and 12 may coincide with the asthma and atopy loci on the same chromosomes. Polymorphism in the IL1 cluster on chromosome 2 has also been shown to influence the severity of the disease (95, 96).
The common gamma chain is encoded by the gene IL-2 receptor gamma, or IL-2RÎ³, which is located on the X-chromosome. For this reason, immunodeficiency caused by mutations in IL-2RÎ³ is known as X-linked severe combined immunodeficiency. Most cases of SCID are due to mutations in the gene encoding the common gamma chain (Î³c), a protein that is shared by the receptors for interleukins IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.