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NSAIDs. Nonsteroidal anti-inflammatory drugs work to help treat the symptoms of gout as well as other forms of arthritis. Over-the-counter NSAIDs such as naproxen sodium and prescription-level medications such as indomethacin can reduce the pain and swelling of a gout attack.
Medications for Treating An Acute Gout Attack. Here are the medications used to treat an acute gout attack. Nonsteroidal anti-inflammatory drugs (NSAIDs) NSAIDs are frequently used to quickly relieve the pain and swelling of an acute gout episode and can shorten the attack, especially if taken in the first 24 hours.