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NSAIDs. Nonsteroidal anti-inflammatory drugs work to help treat the symptoms of gout as well as other forms of arthritis. Over-the-counter NSAIDs such as naproxen sodium and prescription-level medications such as indomethacin can reduce the pain and swelling of a gout attack.
Allopurinol helps to lower uric acid levels by inhibiting the enzyme (xanthine oxidase) responsible for converting purines into uric acid, which reduces the production of uric acid. However, allopurinol is not a painkiller and will have no effect during an attack of gout.