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The immunoassay detected the 14-3-3 protein in cerebrospinal fluid from 68 of the 71 patients with CreutzfeldtâJakob disease (96 percent; 95 percent confidence interval, 92 to 99 percent). Among 94 patients with other dementias, the specificity was 96 percent.
The CSF has a composition identical to that of the brain ECF but this is different from plasma. The major differences from plasma are: 1  The pCO 2 is higher (50 mmHg) resulting in a lower CSF pH (7.33). 2  The protein content is normally very low (0.2g/l) resulting in a low buffering capacity.erebrospinal fluid (CSF) is considered a part of the transcellular fluids. It is contained in the ventricles and the subarachnoid space and bathes the brain and spinal cord. The CSF is contained within the meninges and acts as a cushion to protect the brain from injury with position or movement.