Remember, your problem statement is the backbone of the proposal and the feasibility report. By giving careful consideration to how you construct it now (for the proposal), you can use it when doing your research and writing for the proposal as well as the progress and the feasibility report.
http://www.ohsu.edu/research/skachlab/an... follow this link and it will take to a page where it describe very clearly the sequences of event that occurs during translocation. animated clips are also included which i believed will allow you to understand the process more clearly.
Following binding, and while the binding site is facing the same way, the carrier will capture or occlude (take in and retain) the substrate within its molecular structure and cause an internal translocation so that the opening in the protein now faces the other side of the plasma membrane.