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Quick Answer. Hand, foot and mouth disease in adults is caused by transmission from a person infected with the Coxsackievirus, according to Mayo Clinic. The virus is transmitted by personal contact such as exposure to nasal secretions, saliva, fluid from blisters, throat discharge or stool of an infected individual. Keep Learning.
Along with painful mouth sores, hand, foot and mouth disease causes fever and a rash on both the hands and the feet. Hand, foot and mouth is due to a virus that lives in the intestines, and it is very contagious, said William Schaffner, an infectious diseases specialist at Vanderbilt University. He noted that late summer and early fall are when enteroviruses -- those related to the intestines -- seem to spread readily.