Remember, your problem statement is the backbone of the proposal and the feasibility report. By giving careful consideration to how you construct it now (for the proposal), you can use it when doing your research and writing for the proposal as well as the progress and the feasibility report.
http://www.ohsu.edu/research/skachlab/an... follow this link and it will take to a page where it describe very clearly the sequences of event that occurs during translocation. animated clips are also included which i believed will allow you to understand the process more clearly.
The most common translocation in humans involves chromosomes 13 and 14 and is seen in about 0.97 / 1000 newborns. Carriers of Robertsonian translocations are not associated with any phenotypic abnormalities, but there is a risk of unbalanced gametes that lead to miscarriages or abnormal offspring. For example, carriers of Robertsonian translocations involving chromosome 21 have a higher chance of having a child with Down syndrome.