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Answer. It must occur in the nucleus where the DNA in the cell is located. However, once mRNA is produced, it leaves the nucleus and protein synthesis â translation â occurs in the cytoplasm.t must occur in the nucleus where the DNA in the cell is located. However, once mRNA is produced, it leaves the nucleus and protein synthesis â translation â occurs in the cytoplasm.
The process of translation. Translation takes place on the ribosomes in the cytoplasm, or found on the rough Endoplasmic Reticulum (ER): 1  the ribosomes are the sites of protein synthesis. 2  the mRNA strand attaches to a ribosome. 3  tRNA molecules [molecules: a collection of two or more atoms held together by chemical bonds.4  each mRNA codon codes for a specific amino acid. 5  the ....fter translation, the protein passes into the channels of the rough endoplasmic reticulum (ER) for transportation. The protein is then passed from the rough ER to the Golgi apparatus inside tiny fluid-filled sacs, called vesicles.