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A 60-minute massage can lower cortisol, a hormone thatâs produced in response to stress, by an average of 30 percent. And when cortisol levels decline, serotonin â one of the bodyâs anti-pain mechanisms â increases by an average of 28 percent after receiving a massage.
1 A 2010 meta-analysis of 17 clinical trials concluded that massage therapy may help to reduce depression.  Brief, twice-weekly yoga and massage sessions for 12 weeks were associated with a decrease in depression, anxiety, and back and leg pain in pregnant women with depression, a 2012 NCCIH-funded clinical trial showed.