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lose - allow to go out of sight; The detective lost the man he was shadowing after he had to stop at a red light 7. lose - fail to make money in a business; make a loss or fail to profit; I lost thousands of dollars on that bad investment!; The company turned a loss after the first year turn a loss break even - make neither profit nor loss
The Principle of Use or Lose implies that when it comes to fitness, you use it or lose it. This simply means that your muscles build strength (hypertrophy) with use and lose strength (atrophy) with lack of use.