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Author: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand,1999. Exfoliative keratolysis is a common skin condition in which there is focal peeling of the palms and less often the soles. It is also known as âkeratolysis exfoliativaâ, dyshidrosis lamellosa sicca, and âfocal palmar peelingâ.
1 The rash will usually disappear in about three to five days.  During recovery, after the rash is gone, skin on the palms of the hands and soles of the feet begins to flake and peel off. In severe cases, fingernails, toenails, and hair may fall out. Other areas of skin may also begin to flake and peel.