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The immunoassay detected the 14-3-3 protein in cerebrospinal fluid from 68 of the 71 patients with CreutzfeldtâJakob disease (96 percent; 95 percent confidence interval, 92 to 99 percent). Among 94 patients with other dementias, the specificity was 96 percent.
CSF analysis indicated hypoglycorrhachia, elevated protein level, and neutrophilic pleocytosis. The typical cerebrospinal fluid (CSF) findings in patients with TBRM reveal an active inflammatory response with lymphocytosis, hypoglycorrhachia, and elevated protein level, probably as a result of CSF flow blocks.