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Symptoms and Causes of Moon Facies. Moon facies may cause the face to gradually become round, full, or puffy. The sides of your face may become so round from the buildup of fat that the ears can't be seen from the front of your face. Fat deposits in the sides of the skull can also make the face look rounder.
Conditions that can result in swelling of the entire face include: âº Allergic reactions: An allergic reaction can cause swelling and puffiness of the face. The reaction could be due to a medication, food, blood transfusion, bee sting or due to any other reason. The swelling may be accompanied by a rash and itching.