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Step 3. Talk to your doctor about possible medical causes for the puffiness. Certain medications can cause you to retain water, and allergies, conjunctivitis and allergies --such as hay fever--can cause your face to look puffy. If thereâs a medical cause behind the problem, your health care provider will recommend a change in medication or other adjustments to fix the problem.
Conditions that can result in swelling of the entire face include: âº Allergic reactions: An allergic reaction can cause swelling and puffiness of the face. The reaction could be due to a medication, food, blood transfusion, bee sting or due to any other reason. The swelling may be accompanied by a rash and itching.