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The reduction in the rate of systolic ejection following elevation of aortic pressure leads to changes in cardiac output opposite to alteration in peripheral resistance, thus tending to maintain a relatively constant arterial pressure.
The diameter of a vessel is the determining factor in how rapidly the pressure will drop as well as how easily blood will flow. As blood is flowing through a vessel some of the blood is in direct contact with the vessel's wall and loses energy through friction. This concept is referred to as peripheral resistance (PR). The energy loss decreases the blood pressure as flow continues through the vessel.