12/30/2016. Where We Are. The Savannah River Site (SRS), a 310 square mile (198,046 acres) Department of Energy site, is located in the sand-hills region of South Carolina. It encompasses parts of Aiken, Barnwell and Allendale counties and is bordered on the west by the Savannah River and Georgia.
The NOD2 gene provides instructions for making a protein that plays an important role in immune system function. The NOD2 protein is active in some types of immune system cells (including monocytes, macrophages, and dendritic cells), which help protect the body against foreign invaders such as viruses and bacteria.rohn disease-increased risk from variations of the NOD2 gene. Approximately 40 variations in the NOD2 gene have been associated with an increased risk of Crohn disease, a complex disorder of the digestive system.
1 Four NOD2 polymorphisms were identified for the first time in the Indian population. 2  Of 8 NOD2 polymorphisms, none were associated with CD but two were weakly associated with UC. 3  NOD2 polymorphisms do not play a major role in CD genesis in India. Mutations in the NOD2 gene may put patients both at an increased risk for acquiring M. tuberculosis infections as well as at an increased risk of intestinal failure after extensive intestinal resection. 2  present meta-analysis suggested that NOD2 Arg702Trp polymorphism was likely to be a protective factor for TB.