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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
These conditions may dilate only one pupil, or they may dilate the pupils to a different degree on each side, resulting in unequal pupil size. Pupils that do not respond to light or other stimuli are called fixed pupils. Often, abnormally dilated pupils are also fixed pupils.Dilated pupils or pupils that are unequal in size can be a sign of serious conditions affecting the brain, including stroke, bleeding or tumor and often signal the presence of a medical emergency.Head trauma may also produce dilated or unequal pupils that accompany other brain injuries.ften, abnormally dilated pupils are also fixed pupils. Dilated pupils or pupils that are unequal in size can be a sign of serious conditions affecting the brain, including stroke, bleeding or tumor and often signal the presence of a medical emergency.