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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
What are some causes of an abnormally large (dilated or mydriatic) pupil? After trauma to the eye, the iris tissue can be injured causing the pupil to not constrict to bright light normally. Another possible cause is Adieâs tonic pupil syndrome. This is a condition most common in young adult females, which usually begins in one eye. The pupil is sluggish to react to light.