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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
Dilated pupils that are fixed and do not respond to light are one sign of death. Dilated pupils can also be a sign of a wide variety of plant poisonings or chemical poisonings. Dilated pupils can be due to black nightshade poisoning and toxic mushroom poisoning.xcessively dilated pupils (mydriasis) or unequal pupils can be a sign or symptom of a wide variety of mild to serious diseases, disorders and conditions.