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Homeobox gene: A gene containing a short DNA sequence of about 180 base pairs referred to as a homeobox. Homeobox genes encode proteins that bind and regulate the expression of DNA in multicellular organisms.
Mutations in the homeotic genes can occur, leading to what are known as homeotic mutants. These mutants display ectopic placement of body parts (such as antennae growing at the posterior of the fly instead of at the head) or abnormal expression of the homeotic gene.ne of the most commonly studied model organisms in regards to homeotic genes is Drosophila, specifically Drosophila melanogaster. The homeotic genes of this organism occur in either the Antennapedia complex (ANT-C) or the Bithorax complex (BX-C).