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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
Problems that can lead to coma include: 1  Trauma: Head injuries can cause the brain to swell and/or bleed. 2  Swelling: Swelling of brain tissue can occur even without distress. 3  Bleeding: Bleeding in the layers of the brain may cause coma due to the compression on the injured side of the brain.