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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
The most common cause of temporal lobe lesions is a CVE. Space-occupying lesions may be primary brain tumours - benign (such as meningioma) or malignant. They may also be secondary tumours or metastatic carcinoma, most often from lung cancer or breast cancer.