1 The results of prophylactic measures for femoral head AVN have considerable variation, but certain generalizations can safely be stated. 2  Namely, the clinical results of core decompression alone deteriorate with more advanced lesions.
1 Melasma is very common skin ailment. It can occur to anyone, but young women with brownish tone are more likely to contract with it.  The condition is often linked with female hormonal changes. Change in level of estrogen and progesterone may cause melasma.
The genetic control of skin color is based on a combination of specific hormones and specific receptors in the skin. The major receptor for the production of melanin is the melanocortin1 receptor (MC1R), of which there are five types. There are three major melanocyte-stimulating hormones that are produced by cells in the intermediate lobe of the pituitary gland.