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1 After you eat, carbohydrates break down into sugar and enter the bloodstream in the form of glucose, a sugar that serves as a primary source of energy. 2  Normally, the pancreas responds by producing insulin, which allows sugar to enter the tissues.
When it is needed for energy, glycogen is broken down and converted again to glucose. Glycogen phosphorylase is the primary enzyme of glycogen breakdown. For the next 8â12 hours, glucose derived from liver glycogen is the primary source of blood glucose used by the rest of the body for fuel.Glucagon, another hormone produced by the pancreas, in many respects serves as a countersignal to insulin.or the next 8â12 hours, glucose derived from liver glycogen is the primary source of blood glucose used by the rest of the body for fuel. Glucagon, another hormone produced by the pancreas, in many respects serves as a countersignal to insulin.