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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
It depends on how long you were on Depo and how your body reacted to it, and possibly some other factor we're not aware of. It can take up to 18 months for the effects of Depo to fully wear off, but some women bounce right back within a month after when you were due for your shot.