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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
The DEPO will stay in your system for 3 months but you can become pregnant and conceive, before the 3 month time frame is up. One in a 100 women getting a Depo shot every 12 weeks will get pregnant in a year. After stopping it takes on average a further 9-10 months to get pregnant.he DEPO will stay in your system for 3 months but you can become pregnant and conceive, before the 3 month time frame is up. One in a 100 women getting a Depo shot every 12 weeks will get pregnant in a year. After stopping it takes on average a further 9-10 months to get pregnant.