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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
Causes of Brain Contusions. Brain contusions are most often caused by an impact to the head, such as those sustained in a car accident, a fall, or a sports-related accident. In some cases the brain is injured right below the site of impact, while in other cases the injury occurs on the opposite side of the impact.