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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
Some neurologic conditions, such as stroke, tumor, or brain injury, can also cause changes in pupil size in one or both eyes. Pupils that do not respond to light or other stimuli are called fixed pupils. Often, fixed pupils are also dilated pupils.Abnormally shaped pupils can occur as a result of abnormalities of prenatal development or injury. Changes in pupil size and unequal pupil size can occur with serious conditions such as head trauma, brain tumors, stroke, or poisoning.These conditions are medical emergencies. Seek immediate medical care (call 911) if you have pupil changes as a result of head trauma or in association with other symptoms.bnormally shaped pupils can occur as a result of abnormalities of prenatal development or injury. Changes in pupil size and unequal pupil size can occur with serious conditions such as head trauma, brain tumors, stroke, or poisoning.