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Lumbar disc herniation with sciatica may be associated with increased CSF total protein. CSF protein concentration is slightly higher in males with depressive disorders than in women with similar diagnoses. CSF protein is within normal limits in 66% of patients with multiple sclerosis.
Inflammation or Infection. One underlying cause of elevated levels of protein in the blood is a long-lasting infection or chronic inflammation. The chronic stimulation of the immune system caused by the inflammation or an infection causes the consistent production of antibody proteins.he type of protein circulating in the blood is often an antibody. The plasma cell that produces antibodies is part of the immune system, and thus, elevated protein levels in the blood may indicate an immune system disorder. Importantly, a high-protein diet does not cause elevated protein levels in the blood.