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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
How effective is it? For typical users, approximately 3 out of every 100 women using Depo-Provera will experience an accidental pregnancy in the first year. Depo-Provera starts working within 24 hours of the first shot if injected within 5 days of beginning a period.