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Lumbar disc herniation with sciatica may be associated with increased CSF total protein. CSF protein concentration is slightly higher in males with depressive disorders than in women with similar diagnoses. CSF protein is within normal limits in 66% of patients with multiple sclerosis.
Production of M protein by the abnormal plasma cells causes high protein levels in the blood. The extra protein can lodge in the kidneys and obstruct blood flow. The abnormal protein can be directly toxic to the cells in the kidneys, as well.