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By Mayo Clinic Staff. It's not clear what causes simple kidney cysts. One theory suggests that kidney cysts develop when the surface layer of the kidney weakens and forms a pouch (diverticulum). The pouch then fills with fluid, detaches and develops into a cyst. Symptoms.
Polycystic kidney disease is a genetic disorder that causes many cysts to grow in the kidneys. PKD cysts cause high blood pressure and problems with blood vessels in the brain and heart. Cysts in the liver can also occur with PKD.