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1 Trauma is another important cause of brain lesions. 2  As mentioned before, trauma can either directly destroy brain tissues or can cause compression and delay of brain blood supply due to the formation of hematoma. 3  Sometimes inflammation causes brain lesions.
Re: What Diseases Cause Brain Lesions. Brain lesion is a very general term, it just means an area of brain tissue that looks abnormal on x-ray, MRI or CAT scan. There are hundreds of different disorders (not to mention injuries) that can cause brain lesions of one type or another.e: What Diseases Cause Brain Lesions. Brain lesion is a very general term, it just means an area of brain tissue that looks abnormal on x-ray, MRI or CAT scan. There are hundreds of different disorders (not to mention injuries) that can cause brain lesions of one type or another.