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Medical Definition of Flare. Flare: 1. an exacerbation of a chronic disease. Sometimes referred to as a flare-up, a flare occurs when symptoms of a disease that has been present for a time suddenly worsen. A flare is a transient worsening in severity of a disease or condition that eventually subsides or lessens.
Flares are the universally understood emergency distress signal alerting oncoming traffic to a life-threatening situation. 1  Three flares create the equivalent safety zone as a police car with an activated light bar.