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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
The causes of organic brain injury are as follows: 1  Bleeding into the brain caused by trauma, also known as an intracerebral hemorrhage. 2  Bleeding into the spaces around the brain, also known as a subarachnoid hemorrhage. 3  Bleeding inside the skull from trauma, known as a subdural hematoma. 4  Concussion from trauma.