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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
28 Feb 2013. This happens sometimes with these hormones. Unfortunately, with Depo-Provera, it takes about 13 weeks or more for it to be out of your system. Talk to your Dr who gave you the Depo shot in the first place and let them know about your symptoms.