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1 Trauma is another important cause of brain lesions. 2  As mentioned before, trauma can either directly destroy brain tissues or can cause compression and delay of brain blood supply due to the formation of hematoma. 3  Sometimes inflammation causes brain lesions.
People can also be born with lesions due to abnormal growth. If people are around bad chemicals or are genetically predisposed to brain cancer, they can grow brain tumors. This is a type of brain lesion caused by abnormal growth of brain tissue, which can alter brain function. Brain lesions can also occur due to vascular issues.