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A third Parkinson's disease medication option for drug-induced parkinsonism patients, MAO B inhibitors prevent the breakdown of dopamine by inhibiting the activity of the enzyme monoamine oxidase B, or MAO B. Options of MAO B inhibitors include selegiline and rasagiline.
NMS may also occur in people taking dopaminergic drugs (such as levodopa) for Parkinson's disease, most often when the drug dosage is abruptly reduced. In addition, other drugs with anti-dopaminergic activity, such as the antiemetic metoclopramide, can induce NMS.