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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
MS lesions in certain areas of the brain may trigger these seizures. However, lesions are very common in MS, and seizures are unusual, so there are probably other factors that play a role in seizures, too. Seizures may be the first noticeable sign of MS before diagnosis.