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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
Pupil: The opening of the iris. The pupil may appear to open (dilate) and close (constrict), but it is really the iris that is the prime mover; the pupil is merely the absence of iris.The pupil determines how much light is let into the eye.Both pupils are usually of equal size.If they are not, the condition is called anisocoria.he pupil may appear to open (dilate) and close (constrict), but it is really the iris that is the prime mover; the pupil is merely the absence of iris.