Another related concept is that neoadjuvant therapy acts on micrometastatic disease. The downstaging is then a surrogate marker of efficacy on undetected dissemination, resulting in improved longtime survival compared to the surgery-alone strategy.
Mexican-American Cesar Chavez (1927-1993) was a prominent union leader and labor organizer. Hardened by his early experience as a migrant worker, Chavez founded the National Farm Workers Association in 1962. His union joined with the Agricultural Workers Organizing Committee in its first strike against grape growers in California, and the two organizations later merged to become the United Farm Workers.
His supporters say his work led to numerous improvements for union laborers. Although the UFW faltered after a few years, after Chavez died in 1993 he became an iconic folk saint in the pantheon of Mexican Americans. His birthday, March 31, has become Cesar Chavez Day, a state holiday in California, Colorado, and Texas.