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On a more subtle level, the effect of ammonia on the brain include reduced cognition, lack of focus, diminished motivation, loss of sense of self, heightened emotionality and extreme mental fog. All commonly found symptoms these days.
Ammonia is one of the by-products of protein metabolism. Elevated blood ammonia levels have been associated with severe liver dysfunction such as hepatic encephalopathy, coma resulting from cirrhosis, severe hepatitis, Reye's syndrome, and drug hepatotoxicity. Also, elevated blood ammonia has been reported in cardiac failure, azotemia, and pulmonary emphysema.