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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
1 Moderate Relative Afferent Pupillary Defect: The affected pupil shows a stable or unchanged level of constriction, followed by dilation to a greater size. 2  Severe Relative Afferent Pupillary Defect: The affected pupil shows an immediate dilation to a greater size.ther Causes of a Relative Afferent Pupillary Defect. 1  Amblyopia, if severe, can lead to a relative afferent pupillary defect. 2  Usually the visual acuity would be 20/400, or worse. 3  Cerebral vascular disease-Usually, it is an optic nerve disorder that leads to an RAPD, rather than an optic tract or visual cortex disorder.