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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
The causes of brain disorders vary with the type of disorder you experience. The following are causes of brain disorders: 1  trauma to the brain. 2  stroke (restricted or reduced oxygen and blood in the brain that leads to cellular death).ou may be at risk for a brain disorder if you: 1  have blunt trauma to the head. 2  have a family history of brain disorders or disease. 3  have a viral infection. 4  have a stroke. 5  smoke tobacco products. 6  stop breathing (can prevent oxygen from reaching the brain).