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Homeobox gene: A gene containing a short DNA sequence of about 180 base pairs referred to as a homeobox. Homeobox genes encode proteins that bind and regulate the expression of DNA in multicellular organisms.
BRCA1 is a human tumor suppressor gene. Like most genes, variations in the BRCA1 gene can be either causal for a given disease, or associated with somewhat higher risk, or benign. However, causal does not mean that there is a 100% certainty that a person with such a variant will develop the disease. For individuals with causal BRCA1 variations, a good clinical summary provided by OMIM states the disease odds as[1]: