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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
Depo-Provera and pregnancy. Once you stop using Depo-Provera, it can take you an average of 9 to 10 months after the last shot to get pregnant. After 2 years, pregnancy rates are the same in women who used Depo-Provera as is in women who used the Pill or an IUD.