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Homeobox gene: A gene containing a short DNA sequence of about 180 base pairs referred to as a homeobox. Homeobox genes encode proteins that bind and regulate the expression of DNA in multicellular organisms.
Hox gene is an example of a homeobox gene. The homeobox sequence codes for a 60 amino acid protein domain known as the homeodomain. The main role of homeodomain is to act as a switch that controls gene transcription. See also: Hox gene.