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1 Freeze drying or lyophilization is a drying method where the solvent is frozen prior to drying and is then sublimed, i.e., passed to the gas phase directly from the solid phase, below the melting point of the solvent.
Lyophilization or freeze drying is a process in which. water is frozen, followed by its removal from the. sample, initially by sublimation (primary drying) and. then by desorption (secondary drying). Freeze-. drying is a process of drying in which water is. sublimed from the product after it is frozen [1].