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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
Depo-Provera can cause irregular bleeding and other side effects. The most common side effect of this birth control shot is irregular bleeding. You may experience bleeding problems for six to 12 months after you first begin using the shot. The most common bleeding problems include: