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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
Causes of brain/skull hemorrhage include: 1  High blood pressure (hypertension) 2  Cerebral aneurysm: a weak spot in a blood vessel of the brain. 3  Arteriovenous malformation (AVM): an abnormal cluster of blood vessels.  Tumors.