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By Mayo Clinic Staff. It's not clear what causes simple kidney cysts. One theory suggests that kidney cysts develop when the surface layer of the kidney weakens and forms a pouch (diverticulum). The pouch then fills with fluid, detaches and develops into a cyst. Symptoms.
Simple Kidney Cyst Causes. The cause of simple kidney cysts is not fully understood, but they do not appear to be inherited. Being male is a risk factor, however, as is age: Almost half of all people age 50 or older have one or more simple cysts in the kidneys.