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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
Birth Control Answer A2857. Depo-provera is a hormone injection that lasts for three months to prevent pregnancy. The first shot of depo-provera is usually given during or few days after the start of a menstrual period. After 24 hours, the shot is effective birth control for the next 13 weeks.