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Homeobox gene: A gene containing a short DNA sequence of about 180 base pairs referred to as a homeobox. Homeobox genes encode proteins that bind and regulate the expression of DNA in multicellular organisms.
Introduction. Homeobox genes are genes found in eukaryotes which play a major part in regulating development. Homeobox genes encode transcription factors, proteins which turn on other genes. A single homeobox gene can cause a cascade of other genes to be turned on, producing an entire body segment of limb.