A bone scan is done to: 1  Find bone cancer or determine whether cancer from another area, such as the breast, lung, kidney, thyroid gland, or prostate gland, has spread (metastasized) to the bone. 2  Help diagnose the cause or location of unexplained bone pain, such as ongoing low back pain.
June 13, 1720, cyclical sign kanoe-ne: The date the original Gohonzon was transcribed by Nichikan Shonin. Cyclical sign refers to one of sixty calendar signs, which are based on the twelve animal signs of the Chinese zodiac and the ten elements of nature according to old Chinese traditions.
The man credited as both the first Sengoku-era daimyo and first example of 'Gekokujo' was Hojo Soun, who came from relatively humble origins to eventually invade Izu province in 1493. Soun and his clan would become a major player in the struggle for power during the Sengoku period. Other well established families such as the Takeda and the Imagawa, who had ruled their domains under the authority of both the Kamakura and Muromachi bakufu, were also able to expand their sphere of influence.