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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
Brain Lesions (Lesions on the Brain) Facts. Brain lesions (lesions on the brain) refers to any type of abnormal tissue in or on brain tissue. Major types of brain lesions are traumatic, infectious, malignant, benign, vascular, genetic, immune, plaques, brain cell death or malfunction, and ionizing radiation. Other chemicals and toxins have been associated with brain lesions as well.