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Early physical symptoms of elevated blood ammonia include fatigue, muscle weakness, loss of appetite, nausea, vomiting, diarrhea, pain in the back, sides or abdomen, or other symptoms of liver and kidney damage.
Ammonia is a byproduct of the metabolism of protein. Biochemical reactions in your body rapidly convert ammonia into less harmful molecules under normal conditions. Liver disease can cause ammonia levels to build up in your body. Your brain is normally protected from the low levels of ammonia in your body by the blood-brain barrier. Liver disfunction can cause ammonia levels to build up in your brain causing permanent brain damage, a condition known as hepatic encephalopathy.