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The bottom line. Elevated ferritin levels are usually due to causes such as acute or chronic inflammation, chronic alcohol consumption, liver disease, renal failure, metabolic syndrome, or malignancy rather than iron overload.
Liver disease is a cause of elevated SF. Injured hepatocytes leak ferritin into the serum, so in liver disease, SF can be considered as another type of liver function test (LFT), along with the transaminases (alanine transaminase [ALT], aspartate aminotransferase [AST]) and gamma-glutamyl transferase (GGT).