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By Mayo Clinic Staff. It's not clear what causes simple kidney cysts. One theory suggests that kidney cysts develop when the surface layer of the kidney weakens and forms a pouch (diverticulum). The pouch then fills with fluid, detaches and develops into a cyst. Symptoms.
Polycystic kidney disease is a genetic disorder that causes numerous cysts (small sacs of fluid) to grow in the kidneys. These cysts can interfere with kidney function and cause kidney failure. (Itâs important to note that individual kidney cysts are fairly common and almost always harmless.