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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
Pupillary reflex. In medicine, there are two pupillary reflexes 1  -. The pupillary light reflex is the reduction of pupil size in response to light. 2  The pupillary accommodation reflex is the reduction of pupil size in response to an object coming close to the eye.he optic nerve is responsible for the afferent limb of the pupillary reflex, or in other words, senses the incoming light. The oculomotor nerve is responsible for the efferent limb of the pupillary reflex; in other words, it drives the muscles that constrict the pupil.