The theoretical model builds on the concept of continental drift developed during the first few decades of the 20th century. The geoscientific community accepted plate-tectonic theory after seafloor spreading was validated in the late 1950s and early 1960s. The lithosphere, which is the rigid outermost shell of a planet (the crust and upper mantle), is broken up into tectonic plates.
These disorders are known as monogenetic disorders (disorders of a single gene). Some examples of monogenetic disorders include: 1  cystic fibrosis, 2  sickle cell anemia,3  Marfan syndrome, 4  Huntington's disease, and.5  hemochromatosis.ome examples of monogenetic disorders include: 1  cystic fibrosis, 2  sickle cell anemia, 3  Marfan syndrome, 4  Huntington's disease, and. 5  hemochromatosis.
Types of single gene disorders. The occurrence of a disease caused by a single gene mutation may occur in several main patterns or modes. These are grouped according to whether the trait is sex specific (generally X-linked) or not (autosomal).As a rule, single gene disorders (also known as Mendelian traits or diseases) are relatively uncommon.Autosomal dominant single gene disorders occur in individuals who contain a single mutant copy of the disease-associated gene.s a rule, single gene disorders (also known as Mendelian traits or diseases) are relatively uncommon. Autosomal dominant single gene disorders occur in individuals who contain a single mutant copy of the disease-associated gene.