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Lumbar disc herniation with sciatica may be associated with increased CSF total protein. CSF protein concentration is slightly higher in males with depressive disorders than in women with similar diagnoses. CSF protein is within normal limits in 66% of patients with multiple sclerosis.
If the amount of protein is higher in the ascites than in the serum, it may be due to liver disease, heart failure, Budd-Chiari, pancreatitis, ovarian cancer, or malnutrition. If the ascites protein is lower, then certain infections and malignancies are more likely.