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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
Among the known possible causes of brain lesions are: 1  Brain aneurysm. 2  Brain AVM (arteriovenous malformation) 3  Brain tumor (both cancerous and noncancerous) 4  Encephalitis. Hydrocephalus (a congenital brain abnormality)  Multiple 1  sclerosis. Traumatic brain injury.