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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
People can also be born with lesions due to abnormal growth. If people are around bad chemicals or are genetically predisposed to brain cancer, they can grow brain tumors. This is a type of brain lesion caused by abnormal growth of brain tissue, which can alter brain function. Brain lesions can also occur due to vascular issues.