1 In a dry sink, pour at least 1 cup of baking soda down the blocked drain, and ensure that the powder makes its way down the drain. 2  Next, pour approximately 2 cups of boiling water in and wait several minutes.3  Add one more cup of baking soda in and immediately follow it with one cup of plain white vinegar. In a dry sink, pour at least 1 cup of baking soda down the blocked drain, and ensure that the powder makes its way down the drain. 2  Next, pour approximately 2 cups of boiling water in and wait several minutes.
Tricyclic antidepressants (TCAs) are a class of antidepressant medications that share a similar chemical structure and biological effects. Scientists believe that patients with depression may have an imbalance in neurotransmitters, chemicals that nerves make and use to communicate with other nerves.
TCAs were the first medications that had dual mechanism of action. The mechanism of action of tricyclic secondary amine antidepressants is only partly understood. TCAs have dual inhibition effects on norepinephrine reuptake transporters and serotonin reuptake transporters. Increased norepinephrine and serotonin concentrations are obtained by inhibiting both of these transporter proteins. TCAs have substantially more affinity for norepinephrine reuptake proteins than the SSRIs.