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Lumbar disc herniation with sciatica may be associated with increased CSF total protein. CSF protein concentration is slightly higher in males with depressive disorders than in women with similar diagnoses. CSF protein is within normal limits in 66% of patients with multiple sclerosis.
1 Primary or essential thrombocytosis â Abnormal cells in the bone marrow cause an increase in platelets, but the reason is unknown. 2  Secondary thrombocytosis â The same condition as primary thrombocytosis, but may be caused by an ongoing condition or disease such as anemia, cancer, inflammation, or infection.