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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
MRI showing a brain lesion. A brain lesion is an abnormality seen on a brain-imaging test, such as magnetic resonance imaging (MRI) or a computerized tomography (CT) scan. On CT or MRI scans, brain lesions appear as dark or light spots that don't look like normal brain tissue. Usually, a brain lesion is an incidental finding unrelated to the condition or symptom that led to the imaging test in the first place. A brain lesion may involve small to large areas of your brain, and the severity of the underlying condition may range from relatively minor to life-threatening. Causes.