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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
Depo-Provera is prescribed by a doctor and given as an injection once every 12 weeks. You should get your first shot within five days of beginning a period, unless you are presently using the Pill or an IUD. If you get your first Depo-Provera shot later than five days after your period, you will need to use condoms for the first seven days following the shot. If you want to continue to use Depo-Provera for birth control, you must return for another shot in 11 to 12 weeks, but no later than 13 weeks.