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On a more subtle level, the effect of ammonia on the brain include reduced cognition, lack of focus, diminished motivation, loss of sense of self, heightened emotionality and extreme mental fog. All commonly found symptoms these days.
High levels of ammonia in the blood are dangerous and can cause symptoms such as confusion, sluggishness, and coma. High ammonia levels in the blood can result from acute liver failure. Cirrhosis of the liver and poor liver function can also cause high levels.