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1 Trauma is another important cause of brain lesions. 2  As mentioned before, trauma can either directly destroy brain tissues or can cause compression and delay of brain blood supply due to the formation of hematoma. 3  Sometimes inflammation causes brain lesions.
The causes of brain disorders vary with the type of disorder you experience. The following are causes of brain disorders: 1  trauma to the brain. 2  stroke (restricted or reduced oxygen and blood in the brain that leads to cellular death).ou may be at risk for a brain disorder if you: 1  have blunt trauma to the head. 2  have a family history of brain disorders or disease. 3  have a viral infection. 4  have a stroke. 5  smoke tobacco products. 6  stop breathing (can prevent oxygen from reaching the brain).