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1 Freeze drying or lyophilization is a drying method where the solvent is frozen prior to drying and is then sublimed, i.e., passed to the gas phase directly from the solid phase, below the melting point of the solvent.
The theoretical principle of freeze drying is clearly defined in the diagram Pressure Temperature (Fig A) . In order to avoid the liquid phase, it is absolutely essential to lower the partial pressure of water, below the triple point pressure.