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1 Trauma is another important cause of brain lesions. 2  As mentioned before, trauma can either directly destroy brain tissues or can cause compression and delay of brain blood supply due to the formation of hematoma. 3  Sometimes inflammation causes brain lesions.
The causes of organic brain injury are as follows: 1  Bleeding into the brain caused by trauma, also known as an intracerebral hemorrhage. 2  Bleeding into the spaces around the brain, also known as a subarachnoid hemorrhage. 3  Bleeding inside the skull from trauma, known as a subdural hematoma. 4  Concussion from trauma.