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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
Usually not: A good time to get the Depo Provera injection is during or right after the period, because it is very unlikely a woman will be pregnant when having a normal period. The shot takes several days to take effect, so by 4 days after the Depo Provera injection a woman should not be able to get pregnant.