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Lumbar disc herniation with sciatica may be associated with increased CSF total protein. CSF protein concentration is slightly higher in males with depressive disorders than in women with similar diagnoses. CSF protein is within normal limits in 66% of patients with multiple sclerosis.
Many different diseases cause high urine protein. Healthy kidneys prevent proteins in the blood stream from spilling into the urine. This is why doctors often first suspect kidney disease when a patient presents with elevated urine protein, or proteinuria. Proteinuria often occurs when the kidneys become inflamed or diseased.