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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
It may take up to a year. One important thing to remember is that it can take a long time for Depo Provera to get out of your system. The average time that it takes for Depo to get out of your system is 12 months, and sometimes longer.It does take the body a long time to return to normal after Depo Provera shots, and it takes a long time for the Depo to get out of your system.There is really no way to ârushâ the Depo out of your system, and no way to make it happen faster. You just have to give your body enough time to let it happen naturally.t does take the body a long time to return to normal after Depo Provera shots, and it takes a long time for the Depo to get out of your system. There is really no way to ârushâ the Depo out of your system, and no way to make it happen faster. You just have to give your body enough time to let it happen naturally.