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1 Trauma is another important cause of brain lesions. 2  As mentioned before, trauma can either directly destroy brain tissues or can cause compression and delay of brain blood supply due to the formation of hematoma. 3  Sometimes inflammation causes brain lesions.
1 Swelling: Swelling of brain tissue can occur even without distress. 2  Sometimes a lack of oxygen, electrolyte imbalance, or hormones can cause swelling. 3  Bleeding: Bleeding in the layers of the brain may cause coma due to swelling and compression on the injured side of the brain.