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Homeobox gene: A gene containing a short DNA sequence of about 180 base pairs referred to as a homeobox. Homeobox genes encode proteins that bind and regulate the expression of DNA in multicellular organisms.
Homeobox gene expression in Drosophila melanogaster. Hox genes are a complex of genes whose proteins bind to the regulatory regions of target genes. The target genes then activate or repress cell processes to direct the final development of the organism. Hox genes have a DNA sequence known as the homeobox. The homeobox is a 180 nucleotide-long DNA sequence which codes for a 60 amino acid-long protein domain known as the homeodomain. This works by binding with DNA. Hox genes are in gene clusters on the genome.