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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
Depo-Provera is a contraceptive method for women. Itâs made of a hormone similar to progesterone. It's a shot that a doctor gives you in the arm or buttocks. Each shot works for up to 12 to 14 weeks, but you must get the injection once every 12 weeks to get its full protection.ow Soon Does It Work? Depo-Provera starts to work as birth control immediately after the first shot, if you get it within the first 5 days of your menstrual period.