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As enzymes are made up of protein, they can be denatured by the means of physical action like due to change in pH, temp. and pressure, or by cemical procedure by acting some enzymes on them they can be denatured. 5 people found this useful.
When an enzyme is denatured the active sites of the enzyme change shape (often because the enzyme is out of its tolerated ranges) the substrates are then unable to fit perfectâ¦ly, as needed to complete the process. Therefor when an enzyme is denatured, it cannot function properly and complete its process.