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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
Your clinician will instruct you as to when the next injection is due. It is also safe to have the Depo-ProveraÂ® injection a few weeks early if the 3-month. date is not convenient. If it is greater than 13 weeks since the last injection, use another reliable form of birth control (such as condoms and spermicides), or refrain from intercourse until the next injection is given. Advantages.