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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
1 This bone loss is reversible if Depo-Provera is stopped. 2  With Depo-Provera, it is not possible to stop the side effects until the shot wears off, which may take 12 to 14 weeks. 3  If pregnancy is desired, it takes 12 to 18 weeks to get pregnant after the last shot is taken (sometimes longer). This bone loss is reversible if Depo-Provera is stopped. 2  With Depo-Provera, it is not possible to stop the side effects until the shot wears off, which may take 12 to 14 weeks. 3  If pregnancy is desired, it takes 12 to 18 weeks to get pregnant after the last shot is taken (sometimes longer).