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The reduction in the rate of systolic ejection following elevation of aortic pressure leads to changes in cardiac output opposite to alteration in peripheral resistance, thus tending to maintain a relatively constant arterial pressure.
â¢ With increased stroke volume, due to increased venous return and/or increased contractility, there. is an increased cardiac output and increased blood pressure. Page 15. Summary. â¢ Increases in peripheral resistance, blood volume, and cardiac output result in higher blood pressure. Conversely decreases in any of these factors lead to lower blood pressure. â¢ Three main sources of peripheral resistance: Blood vessel diameter, blood viscosity, and total vessel.