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Parkinson's diseaseback to top. As Parkinson's disease progresses, it often results in a progressive dementia similar to dementia with Lewy bodies or Alzheimer's. Symptoms: Problems with movement are common symptoms of the disease. If dementia develops, symptoms are often similar to dementia with Lewy bodies. Brain changes: Alpha-synuclein clumps are likely to begin in an area deep in the brain called the substantia nigra.
Pick's disease, is a term that can be used in two different ways. It has traditionally been used as a term for a group of neurodegenerative diseases with symptoms attributable to frontal and temporal lobe dysfunction. Common symptoms that are noticed early on are personality and emotional changes, as well as, deterioration of language. This condition is now more commonly called frontotemporal dementia by professionals, and the use of Pick's disease as a clinical diagnosis has fallen out of fashion.