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As enzymes are made up of protein, they can be denatured by the means of physical action like due to change in pH, temp. and pressure, or by cemical procedure by acting some enzymes on them they can be denatured. 5 people found this useful.
Denaturing of enzymes. The important part of an enzyme is called the active site. This is where specific molecules bind to the enzyme and the reaction occurs. Anything that changes the shape of the active site stops the enzyme from working.This is similar to a key that opens a door lock.he important part of an enzyme is called the active site. This is where specific molecules bind to the enzyme and the reaction occurs. Anything that changes the shape of the active site stops the enzyme from working.