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1 Trauma is another important cause of brain lesions. 2  As mentioned before, trauma can either directly destroy brain tissues or can cause compression and delay of brain blood supply due to the formation of hematoma. 3  Sometimes inflammation causes brain lesions.
Causes of Brain Contusions. Brain contusions are most often caused by an impact to the head, such as those sustained in a car accident, a fall, or a sports-related accident. In some cases the brain is injured right below the site of impact, while in other cases the injury occurs on the opposite side of the impact.