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As enzymes are made up of protein, they can be denatured by the means of physical action like due to change in pH, temp. and pressure, or by cemical procedure by acting some enzymes on them they can be denatured. 5 people found this useful.
Enzymes are said to be substrate specific. A substrate is a molecule that temporarily binds with the. enzyme at an area on the enzyme called the active site. Each enzyme catalyzes one specific reaction. because there is only one type of substrate molecule with the exact shape that will fit in the enzymeâs. active site.