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Lumbar disc herniation with sciatica may be associated with increased CSF total protein. CSF protein concentration is slightly higher in males with depressive disorders than in women with similar diagnoses. CSF protein is within normal limits in 66% of patients with multiple sclerosis.
Causes for Elevated Total Protein. Having lower-than-normal total protein levels is a symptom of many conditions, but high levels are a bit unusual. Chronic inflammation due to hepatitis B or C or the human immunodeficiency virus is one cause. Cancer may also be to blame. Multiple myeloma is a bone marrow cancer that causes an overgrowth of plasma cells.