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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
There is no way to stop the side effects of Depo-Provera â they may continue until the shot wears off, in 12 to 14 weeks. Itâs important that you find a method that wonât make you feel sick or uncomfortable. If the side effects from the birth control shot continue to bother you, talk with your health care provider.