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As enzymes are made up of protein, they can be denatured by the means of physical action like due to change in pH, temp. and pressure, or by cemical procedure by acting some enzymes on them they can be denatured. 5 people found this useful.
If the temperature is increased then the enzyme becomes denatured. This happens at about 50-60 degrees in the human body. When enzymes are heated up too much they vibrate so v â¦ igorously that the bonds holding the protein structure in its specific shape break.The enzyme shape changes and the substrate no longer fits in to the active site.n enzyme that is denatured is one that no longer functions correctly or one that has ceased to function entirely. An enzyme can become denatured if factors such as pH and tem â¦ perature are not closely monitored.