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1 Trauma is another important cause of brain lesions. 2  As mentioned before, trauma can either directly destroy brain tissues or can cause compression and delay of brain blood supply due to the formation of hematoma. 3  Sometimes inflammation causes brain lesions.
Problems that can lead to coma include: 1  Trauma: Head injuries can cause the brain to swell and/or bleed. 2  Swelling: Swelling of brain tissue can occur even without distress. 3  Bleeding: Bleeding in the layers of the brain may cause coma due to swelling and compression on the injured side of the brain. This compression causes the brain to shift, causing damage to the brainstem and the RAS (mentioned above).