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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
How effective is the Depo shot? The birth control shot â Depo-Provera â is one of the most effective methods of birth control available. Each shot of Depo-Provera will protect you from pregnancy for 12 weeks. It works best when you get the birth control shot regularly, every 12 weeks. Fewer than one out of 100 women will get pregnant each year if they always use the birth control shot as directed. About six out of 100 women will get pregnant each year if they donât always use the birth control shot as directed.