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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
Pupil Light Reflex. In an afferent pupillary defect there is a decreased direct response caused by decreased visual function in one eye. This can be demonstrated with the swinging flashlight test, in which the light is moved back and forth between the eyes every two to three seconds. The afferent pupillary defect becomes obvious when the flashlight is moved from the normal to the affected eye, and the affected pupil dilates in response to light.