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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
A pupillary response can be intentionally conditioned as a Pavlovian response to some stimuli. The latency of pupillary response (the time in which it takes to occur) increases with age. Use of central nervous system stimulant drugs and some hallucinogenic drugs can cause dilation of the pupil. In ophthalmology, intensive studies of pupillary response are conducted via videopupillometry. Anisocoria is the condition of one pupil being more dilated than the other.