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Carrier-mediated transport enables molecules with low lipid solubility to traverse the blood-brain barrier. Glucose from blood enters the brain by a transport protein. Glucose is the primary energy substrate of the brain. Glucose transport protein (GLUT-1) is highly enriched in brain capillary endothelial cells. These transporters carry glucose molecules through the blood brain barrier.
The antigen-specific cells contribute to the cell-mediated immunity include CD8+ cytotoxic T lymphocytes (CTLs), and cytokine secreting CD4+ TH (T helper cells)cells that mediate delayed type hypersensitivity. Effector T cells generated in response to antigen are responsible for cell-mediated immunity.ell-mediated immunity is an immune response that does not involve antibodies but rather involves the activation of phagocytes, natural killer cells (NK), antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen.