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The reduction in the rate of systolic ejection following elevation of aortic pressure leads to changes in cardiac output opposite to alteration in peripheral resistance, thus tending to maintain a relatively constant arterial pressure.
The law states that blood flow is proportional to the fourth power of the vessel's internal radius. Therefore, if a blood vessel's radius doubles in size due to vasodilation, the blood flow through the vessel will increase 16 fold. Blood flow can be regulated to individual organs, or it can be considered in total. Total peripheral resistance is defined as the total resistance to flow of blood in the systemic circulation. The arterioles are important regulators of blood flow because of their smaller size and muscular walls.