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By Mayo Clinic Staff. It's not clear what causes simple kidney cysts. One theory suggests that kidney cysts develop when the surface layer of the kidney weakens and forms a pouch (diverticulum). The pouch then fills with fluid, detaches and develops into a cyst. Symptoms.
The most common causes of radiologically evident renal cysts in adults are simple renal cysts, which will be discussed in this topic review; autosomal dominant polycystic kidney disease (PKD); and acquired cystic disease in patients with end-stage renal disease (ESRD) after several years of dialysis, particularly hemodialysis.