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Topic Overview. Uremia (uremic syndrome) is a serious complication of chronic kidney disease and acute kidney injury (also known as acute renal failure).remic syndrome may affect any part of the body and can cause: 1  Nausea, vomiting, loss of appetite, and weight loss. 2  Changes in mental status, such as confusion, reduced awareness, agitation, psychosis, seizures, and coma.
Uremia mostly likely occurs if the patientâs creatinine clearance is way below 10-20 mL/min. then the following signs and symptoms will be observed in the patient: 1  Nausea and vomiting. 2  Fatigue. 3  Edema or swelling. 4  Anorexia or lack of appetite. 5  Muscle cramps. 6  Pruritus or itching of the skin. 7  Visual disturbances.