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Carrier-mediated transport enables molecules with low lipid solubility to traverse the blood-brain barrier. Glucose from blood enters the brain by a transport protein. Glucose is the primary energy substrate of the brain. Glucose transport protein (GLUT-1) is highly enriched in brain capillary endothelial cells. These transporters carry glucose molecules through the blood brain barrier.
blood-brain barrier, n barrier formed by epithelial cells in the capillaries that supply the brain and central nervous system. This barrier selectively allows entry of substances such as glucose, some ions, and oxygen, while blocking entry of other substances.lood-brain barrier, n barrier formed by epithelial cells in the capillaries that supply the brain and central nervous system. This barrier selectively allows entry of substances such as glucose, some ions, and oxygen, while blocking entry of other substances.