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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
You can become pregnant as soon as 3 to 4 months after your last shot. But it takes some women up to a year or 2 to conceive after they stop using this type of birth control. This time frame seems unrelated to how long you used the shot.ow Soon Does It Work? Depo-Provera starts to work as birth control immediately after the first shot, if you get it within the first 5 days of your menstrual period.