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Lumbar disc herniation with sciatica may be associated with increased CSF total protein. CSF protein concentration is slightly higher in males with depressive disorders than in women with similar diagnoses. CSF protein is within normal limits in 66% of patients with multiple sclerosis.
Another cause of elevated blood protein levels is a type of cancer called multiple myeloma. Similar to MGUS, plasma cells produce massive quantities of antibodies that increase the total protein level in the blood. In contrast to MGUS, however, the plasma cells have become cancerous and divided uncontrollably.nflammation or Infection. One underlying cause of elevated levels of protein in the blood is a long-lasting infection or chronic inflammation. The chronic stimulation of the immune system caused by the inflammation or an infection causes the consistent production of antibody proteins.