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As enzymes are made up of protein, they can be denatured by the means of physical action like due to change in pH, temp. and pressure, or by cemical procedure by acting some enzymes on them they can be denatured. 5 people found this useful.
By changing the temperature and pH, the enzyme's three-dimensional shape will alter (its tertiary structure). This change is called denaturation. A denatured protein is then nâ¦ot able to carry out its biological functions. This can be both dangerous or useful.