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As enzymes are made up of protein, they can be denatured by the means of physical action like due to change in pH, temp. and pressure, or by cemical procedure by acting some enzymes on them they can be denatured. 5 people found this useful.
The denaturation of nucleic acids such as DNA due to high temperatures is the separation of a double strand into two single strands, which occurs when the hydrogen bonds between the strands are broken.This process is used during polymerase chain reaction.ote 2: Denaturation can occur when proteins and nucleic acids are subjected to elevated temperature or to extremes of pH, or to nonphysiological concentrations of salt, organic solvents, urea, or other chemical agents. Note 3: An enzyme loses its catalytic activity when it is denaturized.