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By Mayo Clinic Staff. It's not clear what causes simple kidney cysts. One theory suggests that kidney cysts develop when the surface layer of the kidney weakens and forms a pouch (diverticulum). The pouch then fills with fluid, detaches and develops into a cyst. Symptoms.
Facts about the condition. 1. Polycystic kidney disease causes cysts, which are non cancerous fluid-filled sacs, to develop inside the kidneys. Cysts can develop anywhere inside the body, but the kidneys are the most affected. 2. Polycystic kidney disease can exist for a long time before any symptoms occur. When they do occur, symptoms may be high blood pressure, back and side pain, headache, swollen abdomen, frequent urination that may have blood in it, kidney stones, kidney infections and kidney failure.