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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
Problems that can lead to coma include: 1  Trauma: Head injuries can cause the brain to swell and/or bleed. 2  Swelling: Swelling of brain tissue can occur even without distress. 3  Bleeding: Bleeding in the layers of the brain may cause coma due to swelling and compression on the injured side of the brain. This compression causes the brain to shift, causing damage to the brainstem and the RAS (mentioned above).