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Carrier-mediated transport enables molecules with low lipid solubility to traverse the blood-brain barrier. Glucose from blood enters the brain by a transport protein. Glucose is the primary energy substrate of the brain. Glucose transport protein (GLUT-1) is highly enriched in brain capillary endothelial cells. These transporters carry glucose molecules through the blood brain barrier.
Blood-Brain Barrier. formed by endothelial cells; joined by tight junctions; protects neurons from toxic substances, allows the exchange of nutrients and waste products between neurons and blood, prevents fluctuations in composition of blood from affecting the functions of the brain; influenced by astrocytes.