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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
The exact mechanism by which brain atrophy occurs remains incompletely understood. Axonal loss within white matter lesions probably contributes to brain atrophy by two mechanisms: the amount of tissue lost within the lesions themselves, and Wallerian degeneration in pathways related to the lesions.