Traditionally, it has been thought that civilization in the Middle East and the Eastern Mediterranean began in two centers, Sumer in the east between the Tigris and Euphrates, and Egypt in the west along the Nile. The earliest cities are believed to have been built in the flood plains of southern Mesopotamia during the mid-4th millennium BC.
Product life cycle management or PLM is an all-encompassing approach for innovation, new product development and introduction (NPDI) and product information management from ideation to end of life.
PLMS (Periodic Leg Movement during Sleep) also called Periodic Limb Movements during Sleep is characterized by involuntary movements of the legs while asleep. People who suffer from PLMS can be unaware of their limb movements, as they do not always wake from them. PLMS is related to PLMD or Periodic Leg Movement Disorder. These movements happen during the night, at regular intervals before one enters REM sleep.