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Homeobox gene: A gene containing a short DNA sequence of about 180 base pairs referred to as a homeobox. Homeobox genes encode proteins that bind and regulate the expression of DNA in multicellular organisms.
n a gene containing a DNA sequence called the homeobox, which is very similar between species and encodes a DNA-binding domain in the resulting protein molecule. Homeobox genes usually play a role in controlling development of the organism. gene locus, n See locus, gene.