1 The results of prophylactic measures for femoral head AVN have considerable variation, but certain generalizations can safely be stated. 2  Namely, the clinical results of core decompression alone deteriorate with more advanced lesions.
1 Melasma is very common skin ailment. It can occur to anyone, but young women with brownish tone are more likely to contract with it.  The condition is often linked with female hormonal changes. Change in level of estrogen and progesterone may cause melasma.
What causes melasma is not yet clear. It likely occurs when the color-making cells in the skin (melanocytes) produce too much color. People with skin of color are more prone to melasma because they have more active melanocytes than people with light skin.