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Carrier-mediated transport enables molecules with low lipid solubility to traverse the blood-brain barrier. Glucose from blood enters the brain by a transport protein. Glucose is the primary energy substrate of the brain. Glucose transport protein (GLUT-1) is highly enriched in brain capillary endothelial cells. These transporters carry glucose molecules through the blood brain barrier.
Once inside of the cell, these lipid soluble hormones... bind with a specific receptor molecule inside the cytoplasm. In response to injury, cell fragments called platelets get activated to induce clotting. Activated platelets release factors that can in turn bind to specific membrane receptors on nearby cells.