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1 Freeze drying or lyophilization is a drying method where the solvent is frozen prior to drying and is then sublimed, i.e., passed to the gas phase directly from the solid phase, below the melting point of the solvent.
The term âlyophilizationâ. describes a process to produce a product that. âloves the dry stateâ [2]. PRINCIPLE. The main principle involved in freeze drying is a. phenomenon called sublimation, where water. passes directly from solid state (ice) to the vapor. state without passing through the liquid state.