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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
Re: What Diseases Cause Brain Lesions. Brain lesion is a very general term, it just means an area of brain tissue that looks abnormal on x-ray, MRI or CAT scan. There are hundreds of different disorders (not to mention injuries) that can cause brain lesions of one type or another.e: What Diseases Cause Brain Lesions. Brain lesion is a very general term, it just means an area of brain tissue that looks abnormal on x-ray, MRI or CAT scan. There are hundreds of different disorders (not to mention injuries) that can cause brain lesions of one type or another.