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The brain lesions can develop due to a number of reasons. Most prevalent causes of brain lesions are mentioned below: 1  Stroke, vascular injury or impaired supply of blood to the brain is perhaps the leading cause of lesions on the brain.
Answered by The Community. Making the world better, one answer at a time. Cystic encephalomalacia is a serious medical condition that denotes the presence of cystic lesions inside the brain. It may be caused by infection, inflammation or hemorrhaging of the brain.