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1 Trauma is another important cause of brain lesions. 2  As mentioned before, trauma can either directly destroy brain tissues or can cause compression and delay of brain blood supply due to the formation of hematoma. 3  Sometimes inflammation causes brain lesions.
Causes of brain/skull hemorrhage include: High blood pressure (hypertension) Cerebral aneurysm: a weak spot in a blood vessel of the brain. Arteriovenous malformation (AVM): an abnormal cluster of blood vessels.