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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
Pupils get larger (dilate) in dim light and smaller (constrict) in bright light. Usually both pupils are about the same size and respond to light equally. Unequal pupil size is called anisocoria. If pupil sizes are very unequal, a person may notice the discrepancy. More often, unequal pupils are noticed only during a doctor's examination. Unequal pupils themselves usually cause no symptoms, but occasionally a person may have trouble focusing on near objects.