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1 Freeze drying or lyophilization is a drying method where the solvent is frozen prior to drying and is then sublimed, i.e., passed to the gas phase directly from the solid phase, below the melting point of the solvent.
As the reader will note further on, freeze-drying is one of the processes carried out in a vacuum; the conditions are below normal atmospheric pressure Normal (sea level) atmospheric pressure is 1.033 kilograms per square centimeter, or 14.7 pounds per square inch, 760 torr or 1,000 millibars.n the remote type the condenser is housed in a vacuum chamber which is separate from the chamber that houses the frozen objects. This is shown in Figure 2. This type of condenser can be isolated by a valve that will permit defrosting. Smaller freeze-dryers can be defrosted with warm water or natural air.