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As enzymes are made up of protein, they can be denatured by the means of physical action like due to change in pH, temp. and pressure, or by cemical procedure by acting some enzymes on them they can be denatured. 5 people found this useful.
The lock would be the enzyme, and the key the substrate. It's a very specific fit. When an enzyme becomes denatured, it starts to unfold, which changes its shape. Changing the shape of the active site, means that the substrate no longer fits, just as the key would no longer fit if you heated the lock until it melted. Yes! As enzymes are made up of protein, they can be denatured by the means of physical action like due to change in pH, temp. and pressure, or by cemical procedure by ac â¦ ting some enzymes on them they can be denatured. 5 people found this useful.