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Medical Definition of Flare. Flare: 1. an exacerbation of a chronic disease. Sometimes referred to as a flare-up, a flare occurs when symptoms of a disease that has been present for a time suddenly worsen. A flare is a transient worsening in severity of a disease or condition that eventually subsides or lessens.
A: The definition of âflareâ is a worsening of the disease process. If you have arthritis, you've probably experienced a flare at one time or another â your disease seems to be well under control for a while, then suddenly your joints become inflamed and painful. You may experience general malaise and fatigue. The cause of a flare varies depending on the specific disease in question.