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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
Note: continued use of Depo-Provera may stop the menstrual cycle completely and it may take longer than average (9 months-1 year for the menstrual cycle to regulate after stopping it). Once you have gotten a shot of Depo-provera, side effects will not dissipate for 12-14 weeks.