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Homeobox gene: A gene containing a short DNA sequence of about 180 base pairs referred to as a homeobox. Homeobox genes encode proteins that bind and regulate the expression of DNA in multicellular organisms.
Although Hox genes contain and are originally named because of the homeobox sequence, not all homeobox-containing genes are Hox genes (other examples include the POU genes and CDX genes). The homeobox encodes for a protein sequence called the homeodomain, which is a DNA-binding domain.