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Homeobox gene: A gene containing a short DNA sequence of about 180 base pairs referred to as a homeobox. Homeobox genes encode proteins that bind and regulate the expression of DNA in multicellular organisms.
Hox genes are highly conserved across most animal species and are DNA sequences that specify the anterior-posterior axis and segment identity of organisms as they develop. Hox is an abbreviation of homeobox, the name given to the region of DNA of 180 base pairs that codes for a protein domain called homeodomin.