The Battle of Moore's Creek Bridge. Febuary 27, 1776 at Willmington, North Carolina. The news of the Battle of Lexington and Battle of Concord, received in North Carolina a month later, further weakened British authority. Unable to stem the tide of revolution in the colony, Governor Martin abandoned New Bern and fled to Fort Johnston on the lower Cape Fear, arriving there on June 2.
Ubiquitin: A small but extremely important protein that acts the kiss of death to other proteins. Ubiquitin consists of only 76 amino acids.In the normal course of events, proteins are inactivated by the attachment of ubiquitin to them, a process called ubiquitination. Ubiquitin acts as a tag by which the protein-transport machinery ferries a protein to the proteasome for degradation.Antagonizing this process are enzymes that remove ubiquitin from proteins. Ubiquitin is appropriately named since it is ubiquitous and is present in virtually all types of cells.biquitin acts as a tag by which the protein-transport machinery ferries a protein to the proteasome for degradation. Antagonizing this process are enzymes that remove ubiquitin from proteins. Ubiquitin is appropriately named since it is ubiquitous and is present in virtually all types of cells.
Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms.