Solidarity Forever. In the pantheon of American labor history there is a very special place for Ralph Chaplin, the man and his work. As the poet laureate of the Industrial Workers of the World (IWW), he is probably remembered best for giving organized labor its fighting them song, Solidarity Forever ..
Opioid-induced hyperalgesia (OIH) is a state of sensitization of pain receptors caused by opioid use. In OIH, there is a paradoxical response to opioids, in which opioids that are used to produce analgesia will instead induce sensitization to certain painful stimuli. The
Opioids act by binding to opioid receptors, which are found principally in the central and peripheral nervous system and the gastrointestinal tract. These receptors mediate both the psychoactive and the somatic effects of opioids. Opioid drugs include partial agonists and antagonists, which produce moderate or no effect (respectively) but displace other opioids from binding in those receptors. The side effects of opioids may include itchiness, sedation, nausea, respiratory depression, constipation, and euphoria.