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The reduction in the rate of systolic ejection following elevation of aortic pressure leads to changes in cardiac output opposite to alteration in peripheral resistance, thus tending to maintain a relatively constant arterial pressure.
â¢ One of the main factors that affects blood pressure is peripheral resistance. â¢ Blood cells and plasma encounter resistance when they contact blood vessel walls. â¢ If resistance increases, then more pressure is needed to keep blood moving. â¢ Three main sources of peripheral resistance: 1. blood vessel diameter.