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Best Answer: Yes there is a link between having an underactive thyroid and having high cholesterol. In someone with high cholesterol, thyroid function is usually one of the first things that gets investigated.
A high thyroid level (hyperthyroidism) can cause fatigue, weight loss, increased heart rate, intolerance to heat, sweating, irritability, anxiety, muscle weakness, and thyroid enlargement. Kidney disease and liver disease, which cause fatigue when the concentration of certain chemicals in the blood builds up to toxic levels.