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Early physical symptoms of elevated blood ammonia include fatigue, muscle weakness, loss of appetite, nausea, vomiting, diarrhea, pain in the back, sides or abdomen, or other symptoms of liver and kidney damage.
Intestinal ammonia passes into the bloodstream and travels to the liver, which converts ammonia into urea. Urea subsequently passes from the body through the urine. High blood ammonia levels can occur with various forms of chronic liver disease, acute liver failure and gastrointestinal bleeding.