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Depo Provera Shot. Depo-Provera Shot. Depo-Provera, a contraception drug, is a synthetic hormone (progestin), which is injected under the skin. It is 95-99% effective in preventing pregnancy for 3 months. For continued protection against pregnancy, women must return every 3 months for another injection.
Each injection gives you protection against pregnancy for 12 weeks. When you have the Depo-Provera injection within the first five days of your menstrual cycle, it works 24hrs after the injection. When you have the Depo-Provera injection after the first five days of your menstrual cycle, it works after 14 days. When the Depo-Provera injection is given to a woman after she has given birth, or had a miscarriage or an abortion, it works immediately. You can get Depo-Provera from your health care provider.