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Homeobox gene: A gene containing a short DNA sequence of about 180 base pairs referred to as a homeobox. Homeobox genes encode proteins that bind and regulate the expression of DNA in multicellular organisms.
Hox is an abbreviation of homeobox, the name given to the region of DNA of 180 base pairs that codes for a protein domain called homeodomin. These are transcription factors that bind to DNA and regulate the transcription of genes.