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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
The 10 Common Symptoms of Lupus. 3. Joint Inflammation. One of the most common symptoms of lupus is pain and inflammation in the jointsâparticularly in the hands, legs, feet, ankles, hips, and knees. Joint inflammation is typically one of the first signs of lupus, and a normally energetic person may suddenly suffer from extreme joint pain and weakness. Of all the symptoms of lupus, this is the one that usually prompts people to visit their doctor to get a definitive diagnosis. Joint pain and inflammation results from the body mistaking its own tissues for outside intruders. The immune system then attacks them, resulting in inflammation and pain.