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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Here are the ten primary symptoms of lupusâ¦. Skin rashes are very common in individuals suffering from autoimmune diseases. In the case of lupus, a type of rash known as a malar rash or a butterfly rash typically forms on the ears, arms, chest, and face. These rashes are particularly common in the cheeks and across the nose, and usually take the shape of a red, blotchy set of butterfly wings.