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12 weeks of age: Administer the third combination injection and possibly a lyme vaccine inoculation. Generally a lyme vaccine is repeated two weeks later, then once a year. 16 weeks of age: Adminster the last combination vaccine. 12 to 16 weeks of age: Adminster rabies vaccine. The timing of this vaccine may depend on the laws in your area (since this can be a human disease, too). Confirm with your veterinarian and check your local and state laws.
Rabies Vaccinations for Puppies. Vaccinations for puppies are especially important as puppies are vulnerable to a much wider range of diseases than are adult dogs. Puppy vaccination regimens usually begin at between six and four weeks of age.The first vaccinations your puppy receives will be against distemper, parvovirus, and canine hepatitis. Your puppy should receive its first rabies vaccination between 16 and 26 weeks of age.While rabies is a very dangerous disease for both dogs and humans, your puppy is unlikely to catch it from another dog, due to the fact that rabies vaccinations are required by law.He is also unlikely to be exposed to wild animals carrying the disease during these first few months of his life.hile rabies is a very dangerous disease for both dogs and humans, your puppy is unlikely to catch it from another dog, due to the fact that rabies vaccinations are required by law. He is also unlikely to be exposed to wild animals carrying the disease during these first few months of his life.