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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Here are the 10 common symptoms of lupus: One of the most common symptoms of lupus is experiencing muscle aches and pains, and that is exactly what musculoskeletal discomfort means (in a fancy way). According to a survey, more than half of the people who develop lupus report sore and achy muscles as the first symptom.