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The Prokaryotic Cell. Prokaryotes are unicellular organisms that lack organelles or other internal membrane-bound structures . Therefore, they do not have a nucleus, but, instead, generally have a single chromosome: a piece of circular, double-stranded DNA located in an area of the cell called the nucleoid. Most prokaryotes have a cell wall outside the plasma membrane.
  Most of the DNA in a eukaryotic cell is in the nucleus, and that is where DNA replication and transcription occur.In eukaryotic cells, mitochondria and chloroplasts a â¦ lso contain DNA, which performs replication and transcription inside these organelles. In prokaryotic cells there is no nucleus.The DNA is in a region of the cytoplasm called the nucleoid, and that is where DNA replication and transcription occur in these cells.n prokaryotic cells there is no nucleus. The DNA is in a region of the cytoplasm called the nucleoid, and that is where DNA replication and transcription occur in these cells.