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Load Range. Every tire has a load range, and trailer tires are no different. Marked on the sidewall, the load range runs from the lightest weight the tire can carry (Load Range B) to the heaviest (Load Range E). Load range is a measure of an individual tire's maximum capacity to carry a boat and trailer.
The load range of the tire matters too, as does the actual load on the tire. A quick look at any manufacturer's Load and Inflation tables will show, for example, that an 11R22.5 tire on an axle rated and loaded to 13,200 pounds requires 120 psi. If you're running only 100 or 105, the tire is overloaded/underinflated.