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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Lupus treatment is complicated by several things. The course and pattern of lupus symptoms vary widely. Flares and remissions can occur at any time, making it hard to tell how you are responding to treatment or which treatments are most helpful. Some treatment side effects can be as troubling as the symptoms of lupus.