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12 weeks of age: Administer the third combination injection and possibly a lyme vaccine inoculation. Generally a lyme vaccine is repeated two weeks later, then once a year. 16 weeks of age: Adminster the last combination vaccine. 12 to 16 weeks of age: Adminster rabies vaccine. The timing of this vaccine may depend on the laws in your area (since this can be a human disease, too). Confirm with your veterinarian and check your local and state laws.
Rabies Shots. Many states and counties require that cats have rabies shots, and most vets recommend a rabies shot even if it isn't legally necessary. There are three different types of rabies vaccines, so the age your kitten gets her rabies shot depends on the specific vaccine your vet uses. Generally, your little fuzzball will need her rabies shot at the age of 8 or 12 weeks. Your vet may recommend holding off on her core vaccinations until 8 weeks so she can get those and her rabies shot all at once.