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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Symptoms of Lupus. Although most people with Lupus experience symptoms in a few organs only, Lupus can affect any part of the body. Ninety-five percent of people with Lupus experience achy joints, or, 'Arthralgia.' Ninety-percent experience fevers of more than one-hundred degrees, and arthritis or swollen joints.