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Arava Oral. This medication is used to treat rheumatoid arthritis, a condition in which the body's defense system (immune system) fails to recognize the body as itself and attacks the healthy tissues around the joints. Leflunomide helps to reduce the joint damage/pain/swelling and helps you to move better.
Disease-Modifying Anti-Rheumatic Drugs for Arthritis. These drugs, known as DMARDs, are used to manage the pain of rheumatoid arthritis and other autoimmune arthritis conditions. Medications in this class include: 1  Arava (leflunomide).2  Trexall and Rheumatrex (methotrexate). 3  Plaquenil (hydroxychloroquine).4  Cuprimine and Depen (penicillamine).SAIDS, or nonsteroidal anti-inflammatory drugs, are commonly prescribed for arthritis pain and other symptoms. They are available over-the-counter as aspirin (such as Bayer), naproxen (such as Aleve), and ibuprofen (such as Motrin).