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12 weeks of age: Administer the third combination injection and possibly a lyme vaccine inoculation. Generally a lyme vaccine is repeated two weeks later, then once a year. 16 weeks of age: Adminster the last combination vaccine. 12 to 16 weeks of age: Adminster rabies vaccine. The timing of this vaccine may depend on the laws in your area (since this can be a human disease, too). Confirm with your veterinarian and check your local and state laws.
Puppies should receive their first canine distemper, canine adenovirus (infectious canine hepatitis) and canine parvovirus at 7-9 weeks of age, then at 12-13 weeks of age, and finally at 16-18 weeks of age to insure they are solidly protected against these diseases.lso, by law, most states require a yearly rabies vaccination even though studies have shown that many of the rabies vaccines we use give us three years of protection. Many veterinarians, myself included, were suspicious that the vaccines we used were giving much longer periods of protection than one year.