In terms of structure, the humerus serves as a connection between the scapula and the elbow, where it links to the two lower arm bones. The humerus bone of the upper arm (the arm in anatomy refers only to the top part of the upper limb i.e. between the elbow and the shoulder).
FDA Approval for Denosumab. Use in Cancer. Denosumab is approved to treat: Giant cell tumor of the bone. It is used in adults and in adolescents whose bones have finished growing. This use is approved for the Xgeva brand of denosumab. Denosumab is approved to prevent and treat: Broken bones and other bone problems caused by solid tumors that have metastasized (spread) to bone. This use is approved for the Xgeva brand of denosumab. Osteoporosis in postmenopausal women who have a high risk of breaking bones. This use is approved for the Prolia brand of denosumab. Denosumab is also approved to increase bone mass in patients who are at high risk of breaking bones.
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test. Immunoglobulin E (IgE) is one of the 5 classes of immunoglobulins, and is defined by the presence of the epsilon heavy chain.It is the most recently described immunoglobulin, having first been identified in 1966.he function of IgE is also distinct from other immunoglobulins in that it induces activation of mast cells and basophils through the cell-surface receptor Fc epsilon RI. Fc epsilon RI is a high-affinity receptor specific for IgE present at a high density on tissue-resident mast cells and basophils.