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12 weeks of age: Administer the third combination injection and possibly a lyme vaccine inoculation. Generally a lyme vaccine is repeated two weeks later, then once a year. 16 weeks of age: Adminster the last combination vaccine. 12 to 16 weeks of age: Adminster rabies vaccine. The timing of this vaccine may depend on the laws in your area (since this can be a human disease, too). Confirm with your veterinarian and check your local and state laws.
Rabies shots are one of the vaccines you will need to get your new puppy. These shots can be given to puppies that are 16 weeks of age. You will also need to get a vaccine booster when your puppy is a year old. Additional boosters need to be given every three years after the first two Rabies vaccines.