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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
10 Signs and Symptoms of Lupus. Lupus is a type of inflammatory disease that results from the immune system attacking its own tissues. It can come on very strong with symptoms being easy to spot, or it can develop slowly and not even get properly diagnosed for months.