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2',3'-cyclic nucleotide 3'-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin-associated enzyme of the nervous system.Sprinkle TJ. 2',3'-Cyclic nucleotide 3'-phosphohydrolase (E.C. 3.1.4.37; CNPase) is a myelin-associated enzyme.In central and peripheral nervous system tissues, the enzyme is localized almost exclusively in the two cell types that elaborate myelin, the oligodendrocyte and the Schwann cell, respectively.',3'-Cyclic nucleotide 3'-phosphohydrolase (E.C. 3.1.4.37; CNPase) is a myelin-associated enzyme.
The 5'-phosphate group of one nucleotide is linked to the 3'-hydroxyl group of the next nucleotide, creating a backbone of alternating phosphate and pentose residues. There is no phosphodiester bond at each end of the polynucleotide.he RNA chain is synthesized from the 5' end to the 3' end as the 3'-hydroxyl group of the last ribonucleotide in the chain acts as a nucleophile and launches a hydrophilic attack on the 5'-triphosphate of the incoming ribonucleotide, releasing pyrophosphate as a by-product.