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12 weeks of age: Administer the third combination injection and possibly a lyme vaccine inoculation. Generally a lyme vaccine is repeated two weeks later, then once a year. 16 weeks of age: Adminster the last combination vaccine. 12 to 16 weeks of age: Adminster rabies vaccine. The timing of this vaccine may depend on the laws in your area (since this can be a human disease, too). Confirm with your veterinarian and check your local and state laws.
Almost all of my puppies get their first shots between 9 and 10 weeks of age. Prior to that the mother's immunity is still present and the shot does no good, in fact there is some evidence that given too early it will actually interfere with the mother's immunity.