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OxyContin: Side Effects. For those whoâve taken more than the prescribed dosage or who donât tolerate opiates, side effects can include clammy skin, shallow breathing, respiratory arrest, circulatory collapse or death. OxyContin Side effects with the prescribed dosage can include: Impaired thinking or reactions. Constipation.
OxyContin Side Effects in the Kidneys. Oxycodone and the drugâs corresponding metabolites are eliminated by the kidneys following metabolism inside the liver. Although oxycodone can place increased filtration burden on the kidney, the drug does not appear to cause any direct toxic effects on the kidneys.