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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Many of these symptoms occur in other illnesses. In fact, lupus is sometimes called the great imitator because its symptoms are often like the symptoms of rheumatoid arthritis, blood disorders, fibromyalgia, diabetes, thyroid problems, Lyme disease, and a number of heart, lung, muscle, and bone diseases.he most common symptoms of lupus, which are the same for females and males, are: 1  Extreme fatigue (tiredness). 2  Headaches. 3  Painful or swollen joints. 4  Fever. 5  Anemia (low numbers of red blood cells or hemoglobin, or low total blood volume). 6  Swelling (edema) in feet, legs, hands, and/or around eyes.