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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Common signs and symptoms of lupus include painful or swollen joints, muscle pain, fever, extreme fatigue, chest pain with deep inhalation and sun sensitivity. Many people with lupus also have red facial rash, known as a butterfly rash, on the nose and cheeks.Signs and symptoms of lupus vary from person to person.ommon signs and symptoms of lupus include painful or swollen joints, muscle pain, fever, extreme fatigue, chest pain with deep inhalation and sun sensitivity. Many people with lupus also have red facial rash, known as a butterfly rash, on the nose and cheeks. Signs and symptoms of lupus vary from person to person.