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The U.S. Food and Drug Administration yesterday approved a new oral medication for rheumatoid arthritis, or RA. Tofacitinib, brand name Xeljanz (ZEL'jans) , is for patients with moderate to severe rheumatoid arthritis who do not respond well to methotrexate, a disease-modifying antirheumatic drug, or DMARD.
Oral methotrexate is taken one day a week for rheumatoid arthritis. It is not taken daily like most pills. Methotrexate is available in 2.5 milligram tablets. The starting dose for most adults with rheumatoid arthritis is 7.5 to 10 milligrams (i.e., 3 or 4 pills).