Kidneys produce hormones. Normal kidneys also make important chemical messengers called hormones. These hormones circulate in the bloodstream and regulate some body functions such as blood pressure, the making of red blood cells, and the uptake of calcium from the intestine.
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Uno (/ Ë uË n oÊ /; from Italian and Spanish for 'one') (stylized as UNO) is an American shedding-type card game that is played with a specially printed deck. The game's general principles put it into the Crazy Eights family of card games. The game was originally developed in 1971 by Merle Robbins in Reading, Ohio, a suburb of Cincinnati.