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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Your doctor will do a physical exam to check for typical signs and symptoms of lupus, including: 1  sun sensitivity rashes, such as a malar or butterfly rash. 2  mucous membrane ulcers, which may occur in the mouth or nose.  arthritis, which is swelling or tenderness of the small joints of the hands, feet, knees, and wrists.