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12 weeks of age: Administer the third combination injection and possibly a lyme vaccine inoculation. Generally a lyme vaccine is repeated two weeks later, then once a year. 16 weeks of age: Adminster the last combination vaccine. 12 to 16 weeks of age: Adminster rabies vaccine. The timing of this vaccine may depend on the laws in your area (since this can be a human disease, too). Confirm with your veterinarian and check your local and state laws.
These are usually given as a combination vaccine (gives protection against several different diseases) and your pup should have three sets of this combination vaccination, given at 3 week intervals. The Rabies shot is usually give at around 14 - 16 weeks of age.Puppies are extremely susceptible to many serious, contagious dog illnesses while unvaccinated. Several of these can kill a pup very quickly. It is also illegal to have a dog who isn't vaccinated against Rabies.eport Abuse. The dog gets a series of 3 or 4 combination shots, starting at 8 weeks old, and then 4 weeks later, and 4 weeks later (and sometimes one more).