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Renal tubular acidosis, a kidney condition that makes the urine more acidic. Kidney stones form more easily in acidic urine. ... Uric acid, calcium oxalate, and cystine stones form more readily in acidic urine, so this prevention strategy hinges on keeping the urine slightly alkaline.
Because certain medications can make your urine more acidic, your physician also may order the urine pH test to determine if the medicine is making your urine too acidic. The urine pH test can also be used to determine the best medication to prescribe when you have a urinary tract infection.