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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Digestive problems are common in lupus. The symptoms you may experience include nausea, vomiting, diarrhea, or constipation. Drugs you take for lupus such as non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are often the cause.ther symptoms include an enlarged liver, jaundice, itching and skin rashes, joint pain, abdominal discomfort, abnormal blood vessels on the skin (spider angiomas), nausea and vomiting, loss of appetite, dark urine, and pale or gray-colored stools.