The name coupon arose because in the past, paper bond certificates were issued which had coupons attached to them, one for each interest payment. On the due dates the bondholder would hand in the coupon to a bank in exchange for the interest payment.
Hib vaccine. Haemophilus influenzae type B vaccine is a vaccine used to prevent Haemophilus influenzae type b (Hib) infection. In countries that include it as a routine vaccine, rates of severe Hib infections have decreased more than 90%. It has therefore resulted in a decrease in the rate of meningitis, pneumonia, and epiglottitis.
The reconstituted vaccine preparation also contains lactose, sodium chloride and water for injection. The HIBERIX Hib polysaccharide is extracted from a culture of Haemophilus influenzae type b strain 20,752. After activation with cyanogen bromide and derivatisation with an adipic hydrazide spacer, the Hib polysaccharide is coupled to tetanus toxoid via carbodiimide condensation.