One of the most significant long-term effects of cocaine use is damage to the nose. A septal perforation, or a âhole in the septumâ is a condition that is commonly caused from snorting or âsniffingâ cocaine through the nose. The nose has a fragile blood supply, which is shut off by cocaine use. This process is called vasoconstriction (closing off of blood vessels).
Scleroglucan and PSAT are two Beta-1,3/1,6-polysaccharides. Beta glucans are derived primarily from yeast cell wall, various fungi, grains, and mushrooms. Beta 1,4 glucan is derived from oats and barley while not included in this research summary of forms of Beta 1,3/1,6 glucan.
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) agonist, derived from human GLP-1-(7-37), a less common form of endogenous GLP-1. Liraglutide leads to insulin release in pancreatic beta cells in the presence of elevated blood glucose. This insulin secretion subsides as glucose concentrations decrease and approach euglycemia (normal blood glucose level). It also decreases glucagon secretion in a glucose-dependent manner and delays gastric emptying.