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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Here are the 10 most common signs and symptoms of Lupus: Lupus is a disease that generally affects everyone in a different manner. As such, one person could display severe gastrointestinal symptoms, while another could display mild and completely different symptoms.