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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Signs of lupus include: 1  Fatigue or malaise. 2  Joint pain, stiffness or swelling. 3  Muscle pain or weakness. 4  Fever with no known cause. 5  A red, butterfly-shaped rash across the nose and cheeks. 6  Other rashes, particularly on areas of the body exposed to the sun. 7  Pain in the chest when taking a breath.