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Prostatitis is often difficult to treat, in part because several forms of the disease exist and the cause of the most common form is unknown. Some men experience acute flare-ups caused by a bacterial infection of the prostate. This acute bacterial prostatitis is associated with a sudden and continuous pain that lasts for several days. Some men have signs of inflammation, such as white blood cells in their semen, but not the painful symptoms of prostatitis.
Toxins found in the urine allow for bacteria to form that leads to prostate infection and the formation of prostate calcification. Prostate calcification, or prostate stones are believed to be a leading cause of chronic prostatitis and chronic pelvic pain syndrome. Prostate stones are fairly common in men over age 50, and affect up to 75% of middle-aged men who have enlarged prostate or prostate infection.