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Prostatitis is often difficult to treat, in part because several forms of the disease exist and the cause of the most common form is unknown. Some men experience acute flare-ups caused by a bacterial infection of the prostate. This acute bacterial prostatitis is associated with a sudden and continuous pain that lasts for several days. Some men have signs of inflammation, such as white blood cells in their semen, but not the painful symptoms of prostatitis.
In the late 1990s the ineffectiveness of drug treatments for chronic prostatitis led to a brief resurgence of interest in prostate massage. In a recent trial, however, prostate massage was not shown to improve outcomes compared to antibiotics alone. The practice is still used in some parts of China.