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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Symptoms of systemic lupus erythematosus (SLE, often referred to as simply lupus) can be quite different, because there are different types of lupus, and not all affected people show the same symptoms.General symptoms associated with lupus include. 1  low-grade fever, 2  loss of appetite, 3  nausea,4  muscle aches, 5  joint pains, Systemic lupus erythematosus (SLE) is an autoimmune disease. 2  SLE is characterized by the production of unusual antibodies in the blood. 3  The cause(s) of SLE is (are) unknown, however, heredity, viruses, ultraviolet light, and drugs all may play some role.