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12 weeks of age: Administer the third combination injection and possibly a lyme vaccine inoculation. Generally a lyme vaccine is repeated two weeks later, then once a year. 16 weeks of age: Adminster the last combination vaccine. 12 to 16 weeks of age: Adminster rabies vaccine. The timing of this vaccine may depend on the laws in your area (since this can be a human disease, too). Confirm with your veterinarian and check your local and state laws.
A recent case of rabies in a young puppy (less than 16 weeks old) in Alaska has led some vets to question the rationality of making dogs wait until they are 16 weeks old to be vaccinated. Also, many municipalities will not license a dog whose rabies vaccine was given when it was 15 weeks and six days old. recent case of rabies in a young puppy (less than 16 weeks old) in Alaska has led some vets to question the rationality of making dogs wait until they are 16 weeks old to be vaccinated. Also, many municipalities will not license a dog whose rabies vaccine was given when it was 15 weeks and six days old.