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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Facty Health. 10 Symptoms of Lupus. 10 Symptoms of Lupus. Lupus also called systemic lupus erythematous disease (SLE), is a chronic, autoimmune condition in which a patientâs immune system loses its ability to distinguish between disease-causing foreign bodies and naturally occurring human tissues (Self).