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Anti-mitochondrial antibodies (AMA) are autoantibodies, consisting of immunoglobulins formed against mitochondria, primarily the mitochondria in cells of the liver.mmunofluorescence staining pattern of AMA shown on stomach (top left), liver (top right), kidney (bottom left) and hep-20-10 cells (bottom right). Primary biliary cirrhosis is seen primarily in middle-aged women, and in those afflicted with other autoimmune diseases.
Infection with viruses or bacteria triggers the immune system to release proteins called antibodies. The specific part of the virus or bacterium that triggers the antibody response is called an antigen. Once produced by the body (specifically, by the lymphoid tissue, which is part of the body's immune system), antibodies circulate in the bloodstream until they come into contact with an antigen.