Lymphoid tissue: T-lymphocytes and the Thymus The thymus is a primary lymphoid organ found within the superior mediatinum, behind the upper part of the sternum. This organ is active in children, but at the start of puberty, until old age, it starts to atrophy, producing fewer T-cells.
2. Increased risk of infection. PROGRAF is a medicine that affects your immune system. Prograf can lower the ability of your immune system to fight infections. Serious infections can happen in people receiving Prograf that can cause death. Call your doctor right away if you have symptoms of an infection such as: 1  fever.2  sweats or chills.3  cough or flu-like symptoms. 4  muscle aches. 5  warm, red, or painful areas on your skin.erious infections can happen in people receiving Prograf that can cause death. Call your doctor right away if you have symptoms of an infection such as: 1  fever. 2  sweats or chills. 3  cough or flu-like symptoms. 4  muscle aches. 5  warm, red, or painful areas on your skin.
(At the same time, it also causes the kidneys to eliminate potassium.) The body then becomes overloaded with salt and water, and this worsens the heart failure. Spironolactone inhibits the action of aldosterone thereby causing the kidneys to excrete salt and fluid in the urine while retaining potassium. Therefore, spironolactone is classified as a potassium-sparing diuretic, a drug that promotes the output of urine (diuretic) while allowing the kidneys to retain potassium. The FDA approved spironolactone in October 1985.