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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
In lupus, the immune system can damage healthy red blood cells, causing a condition called hemolytic anemia. Having too few red blood cells can lead to symptoms such as fatigue, shortness of breath, dizziness, and a yellowish color to the skin and eyes (jaundice).