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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
(August 2012) Although lupus usually occurs alone, many people with lupus sometimes have symptoms characteristic of one or more of the other connective tissue diseases, like rheumatoid arthritis, scleroderma, Sjogren's syndrome, polymyositis-dermatomyositis, and various forms of vasculitis.