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For the language families subsumed under Khoisan, see Khoisan languages.  Khoisan  (/ËkÉÉªsÉËn/ ; also spelled Khoesaan, Khoesan or KhoeâSan) is a unifying name for two groups of peoples of Southern Africa, who share physical and putative linguistic characteristics distinct from the Bantu majority of the region.arious Y-chromosome studies since confirmed that the Khoisan carry some of the most divergent (oldest) Y-chromosome haplogroups. These haplogroups are specific sub-groups of haplogroups A and B, the two earliest branches on the human Y-chromosome tree.
The Khoe languages were the first Khoisan languages known to European colonists and are famous for their clicks, though these are not as extensive as in other Khoisan language families. There are two primary branches of the family, Khoekhoe of Namibia and South Africa, and TshuâKhwe of Botswana and Zimbabwe.