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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Prior to the onset of a flare, lupus patients may notice a number of indicative signs: Out of proportion and persistent fatigue. Persistent weakness. Aching all over. Slight to high fever. Persistent loss of appetite. Involuntary weight loss. Increasing hair loss.