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The U.S. Food and Drug Administration yesterday approved a new oral medication for rheumatoid arthritis, or RA. Tofacitinib, brand name Xeljanz (ZEL'jans) , is for patients with moderate to severe rheumatoid arthritis who do not respond well to methotrexate, a disease-modifying antirheumatic drug, or DMARD.
For reasons no one fully understands, in rheumatoid arthritis, the immune system-which is designed to protect our health by attacking foreign cells such as viruses and bacteria-instead attacks the body's own tissues, specifically the synovium, a thin membrane that lines the joints.reatment. Treatment of rheumatoid arthritis may involve medications such as non-steroidal anti-inflammatory drugs (NSAIDs), aspirin and analgesics. Corticosteroids, such as prednisone may be prescribed, and are effective in decreasing the inflammation associated with rheumatoid arthritis.