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OxyContin: Side Effects. For those whoâve taken more than the prescribed dosage or who donât tolerate opiates, side effects can include clammy skin, shallow breathing, respiratory arrest, circulatory collapse or death. OxyContin Side effects with the prescribed dosage can include: Impaired thinking or reactions. Constipation.
The most serious risk associated with OxyContin, is respiratory depression. Because of this, OxyContin should not be combined with other substances that slow down breathing, such as alcohol, antihistamines (like some cold or allergy medication), barbiturates, or benzodiazepines.xyContin is the brand name for an opioid analgesic containing the active ingredient oxycodone (also found in Percocet and Percodan).