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12 weeks of age: Administer the third combination injection and possibly a lyme vaccine inoculation. Generally a lyme vaccine is repeated two weeks later, then once a year. 16 weeks of age: Adminster the last combination vaccine. 12 to 16 weeks of age: Adminster rabies vaccine. The timing of this vaccine may depend on the laws in your area (since this can be a human disease, too). Confirm with your veterinarian and check your local and state laws.
Your puppy will need his first rabies shot when heâs about three to four months of age, something that usually is set by your county or town, rather than your vet. Heâll need a booster again in a year, and then once every one to three years after that.our vet will determine the exact schedule, but typically these booster shots are given every two to four weeks until the pup is about 16 weeks old. The reason for the boosters is that puppies normally get some immunity from their mothers, and this natural immunity actually prevents the shots from doing him any good.