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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
However, most forms of collagen vascular disease do share some of the same general symptoms. People with collagen vascular disorders typically experience: fatigue; muscle weakness; fever; body aches; joint pain; skin rash; Symptoms of lupus. Lupus is a collagen vascular disease that causes unique symptoms in each patient. Additional symptoms can include: