In the same way that the removal of a single domino in the row would interrupt the sequence of toppling, Heinrich suggested that removal of one of the factors would prevent the accident and resultant injury; with the key domino to be removed from the sequence being number 3.
6The Impact of the Opioid Crisis on the Healthcare System. An analysis of the increase in per-patient charges from 2013 to 2015 shows that the rise in charges from. $50,490 to $63,356 for individuals with an opioid abuse or dependence diagnosis exceeds the per-.
Aggregate costs for prescription opioid overdose, abuse, and dependence were estimated at over $78.5 billion (in 2013 dollars). Total spending for health care and substance abuse was over $28 billion, most of which ($26 billion) was covered by insurance.