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12 weeks of age: Administer the third combination injection and possibly a lyme vaccine inoculation. Generally a lyme vaccine is repeated two weeks later, then once a year. 16 weeks of age: Adminster the last combination vaccine. 12 to 16 weeks of age: Adminster rabies vaccine. The timing of this vaccine may depend on the laws in your area (since this can be a human disease, too). Confirm with your veterinarian and check your local and state laws.
There are only 12 states that suggest rabies vaccination at 12 weeks, and they donât mandate it â only suggest it. There are 14 states that mandate the vaccine at 16 weeks of age, one state at five months, and several at six months. The remaining states rely on the rabies compendium, which does not say puppies should be vaccinated at 12 weeks.