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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Other symptoms. 1  Raynaud's phenomenon: Some people with lupus have Raynaud's phenomenon. It affects the small vessels that supply blood to the skin and the soft tissues under the skin of the fingers and toes. 2  Hair loss: People with lupus may have periods of hair loss, either in patches or spread evenly over the head.