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12 weeks of age: Administer the third combination injection and possibly a lyme vaccine inoculation. Generally a lyme vaccine is repeated two weeks later, then once a year. 16 weeks of age: Adminster the last combination vaccine. 12 to 16 weeks of age: Adminster rabies vaccine. The timing of this vaccine may depend on the laws in your area (since this can be a human disease, too). Confirm with your veterinarian and check your local and state laws.
Your veterinarian determines when to start and how many boosters your pup should receive based on health status and exposure. Usually, puppies receive a series of either three or four boosters three weeks apart, starting at either six weeks (6, 9, 12, 16 weeks of age) or starting at nine weeks(9, 12 and 16 weeks). Rabies is given at 16 weeks, and all of the core vaccinations are repeated a year later.