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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
People with lupus have periods in which they are feeling well, called remission, and periods of worsening symptoms, called flares. Lupus patients can often predict the onset of flares due to specific warning signs, such as worsening fatigue and/or onset of headache, fever, dizziness, rash, and/or pain (Phillips 1991).