This occurs when a substance passes from the fluid in the tubular lumen through the apical membrane, across the cytosol , and then into the interstitial fluid.
Yes, it's potent stuff. Cat receive it either as an injection or orally. It takes effect in roughly half an hour, lasting about 8 hours before another administration is necessary. Cats usually react negatively to opiates, but buprenorphine is an exception. That's one reason vets use it if they can receive the necessary special certification.
Dogs and Cats: Buprenorphine is usually given. orally to dogs and cats up to three times daily. for relief of pain. Do not give your pet aged. cheese or use tick collars while on this drug. Horses: Horses may rarely receive buprenor-. phine for pain relief as an injection. Buprenor-.