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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Lupus is an autoimmune disease that causes swelling (inflammation) and a wide variety of symptoms. Lupus affects each individual uniquely. Some people have only a few mild symptoms and others have many, more severe symptoms. Symptoms usually start in early adulthood, anywhere from the teen years to the 30s. As with some other autoimmune diseases, people with lupus generally experience flare-ups of symptoms followed by periods of remission.