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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Take a look at the 10 most common symptoms of lupus. 1. Fatigue. One of the most common early symptoms of lupus is fatigue. If youâre feeling tired all the time, it doesnât necessarily mean you have lupus, however. There are lots of causes of fatigue.