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A ganglion is a fluid-filled swelling of the lining of a joint or tendon. Although ganglions can form on any part of the foot, they most often appear on the ankle or top of the foot. Ganglions tend to change size and usually grow slowly.
A cyst is a closed sac which can be filled with fluid or a semi-solid material. A ganglion cyst is a firm, rubbery mass that usually appears on the front or the side of the ankle, although can exist deeper within the joint. It often appears as a result of a tendon injury.