Depression affects different people in different ways, but most of them experience some combination of the following symptoms: 1  Prolonged sadness or feelings of emptiness. 2  Feelings of helplessness or hopelessness. 3  Feelings of guilt or worthlessness.  Anger and 1  irritability. Restlessness.  Difficulty 1  concentrating. Fatigue.  Changes in sleep patterns.
Diphenhydramine (Benadryl Â® , Sominex Â® , and many other brand names) is an antihistamine that is used for a variety of different purposes. The approved uses may vary, depending on the particular product, and there are also a number of  off-label  uses for diphenhydramine.
Due to its strong anticholinergic effects, diphenhydramine is on the  Beers list  of drugs to avoid in the elderly. Diphenhydramine is category B in the FDA Classification of Drug Safety During Pregnancy. It is also excreted in breast milk. Paradoxical reactions to diphenhydramine have been documented, in particular among children, and it may cause excitation instead of sedation.