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For mild to moderate sinusitis or otitis media in adults, doctors prescribe 500 mg of amoxicillin every 12 hours or 250 mg three times a day, states RxList.com. Severe infections require 875 mg of amoxicillin every 12 hours or 500 mg three times a day. Children need 25 mg/kg/day in two divided doses or 20 mg/kg/day given in three equal doses over a 24-hour period for mild to moderate infection.
Top 10 Doctor insights on: How Long Does Antibiotic Take To Work For Ear Infection. 1 How long is it supposed to it take for an antibiotic to work in curing an ear infection? 24-48 hours: You should notice a substantial improvement in your symptoms within 24-48 hours, mainly in the reduction of pain.