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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
Constricted pupils, although overdose may bring about dilated pupils. Overdose deaths can occur due to respiratory suppression, especially when oxycodone or any opiate is combined with another drug that suppresses respiration, like another opiate, benzodiazepines or alcohol.