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For mild to moderate sinusitis or otitis media in adults, doctors prescribe 500 mg of amoxicillin every 12 hours or 250 mg three times a day, states RxList.com. Severe infections require 875 mg of amoxicillin every 12 hours or 500 mg three times a day. Children need 25 mg/kg/day in two divided doses or 20 mg/kg/day given in three equal doses over a 24-hour period for mild to moderate infection.
Amoxicillin often is prescribed based on the level of infection. For example, amoxicillin used to treat an ear infection is often prescribed for 7 to 10 days, or given in three injections.However, for a urinary tract infection, which is often more severe, antibiotics are often taken for 14 days to ensure the infection has fully cleared.moxicillin can best work when it is kept in steady levels in the body. For this reason, it is often prescribed to be taken every 8 to 12 hours. If you miss a dose, resume taking the medication as soon as possible.