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The average half-life of Xanax, which means the time it takes the blood to eliminate half of the drug is 11.2 hours (with a range of 6.3 to 26.9 hours). Xanax XR is an extended release version of the drug.
Like most drugs, Xanax has a limited duration once it is ingested. Normally, Xanax stays in a personâs system for approximately 6 hours. Depending on the personâs weight, that period can extend to 10 hours. If the person is morbidly obese or has liver problems Xanax can linger on in their system for about 40 hours.