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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
Stimulation of the parasympathetic system, known for ârest and digestâ functions, causes constriction. Inhibition of the parasympathetic system can therefore also cause dilation. The size of your pupils at any given time reflects balance of these forces acting simultaneously.