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The average half-life of Xanax, which means the time it takes the blood to eliminate half of the drug is 11.2 hours (with a range of 6.3 to 26.9 hours). Xanax XR is an extended release version of the drug.
Xanax has an elimination half-life that ranges from 9 hours to 16 hours in healthy adults. This means that it will take most people within the span of 9 to 16 hours (post-ingestion) to eliminate 50% of the drug from their body. On average (among most users), the half-life of Xanax is around 12 hours. This means that most people will have fully eliminated (100%) the drug from their system within 4 days.