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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
1 Any drug that dilates your pupils may increase the risk of angle closure glaucoma (narrow angle glaucoma). 2  NSAIDs, non-steroidal anti-inflammatory drugs.  Steroids, cortisone prescriptions such as Prednisone (prelone, deltasone) are the most damaging drugs to the eyes of all prescription drugs.