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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
what is the opposite of dilated pupils medlineplus states that an overdose of opiates is the most common cause of abnormal miosis affecting both eyes opiates include prescription pain medications such as fentanyl morphine and methadone and illicit drugs such as heroin