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The average half-life of Xanax, which means the time it takes the blood to eliminate half of the drug is 11.2 hours (with a range of 6.3 to 26.9 hours). Xanax XR is an extended release version of the drug.
How long do Xanax effects last. The effects of Xanax donât last long. Typically Xanax effects will only last a bout 4 hours. This is why itâs not always the drug of choice for treating chronic anxiety disorders.or example, other drug metabolize and leave the blood within a few hours; Xanax leaves the blood after several days. Furthermore, Xanax is detectable in urine for at least a week after last dose. With chronic or heavy use, Xanax can still be detected a month and a half after the last dose taken.