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The average half-life of Xanax, which means the time it takes the blood to eliminate half of the drug is 11.2 hours (with a range of 6.3 to 26.9 hours). Xanax XR is an extended release version of the drug.
The level of drug reaches a peak in the bloodstream after one to two hours, and its felt effects last on average about 5 hours. However, Xanax remains in the bloodstream long after its anti-anxiety effects have worn off.Xanaxâs average half-life is 11 hours. This means that it takes an average of 11 hours for the body to eliminate half the Xanax dose.In older or obese people, or those with liver disease, Xanaxâs half-life is longer, as long as 40 hours. It takes several half-lives to eliminate a drug completely.So for most people, there may still be a small fraction of Xanax in your blood two days or more after taking a single pill.n older or obese people, or those with liver disease, Xanaxâs half-life is longer, as long as 40 hours. It takes several half-lives to eliminate a drug completely. So for most people, there may still be a small fraction of Xanax in your blood two days or more after taking a single pill.