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The average half-life of Xanax, which means the time it takes the blood to eliminate half of the drug is 11.2 hours (with a range of 6.3 to 26.9 hours). Xanax XR is an extended release version of the drug.
Xanax duration of action. The half-life of Xanax is a lengthy 11 hours. Xanax reaches peak levels in the blood within 2 hours. However, despite taking several days to leave the body, the effects of Xanax tend to wear off after about 4 hours, so it may need to be taken several times throughout the day. How long Xanax stays in the body is rather long, relative to other drugs.