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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
Drugs that trigger the release of dopamine, a related neurotransmitter, can also induce mydriasis. Marijuana is a good example. Dopamine cause pupils to dilate by exciting the adrenergic receptors, what in turn increases adrenaline (which the autonomic nervous system is sensitive to).