1. Ototoxicity -- Vestibular toxicity -- Auditory toxicity 2. Nephrotoxicity Note: Oto/nephrotoxicity are dose-dependent, cumulative, and potentiated by use of other oto/nephrotoxic drugs. Due to toxicity we reserve aminoglycosides for serious infections for which less toxic drugs don't work. Note: Toxicity can be reversible if caught early and patient is taken off aminoglycosides. 3.
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