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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
Rozerem is a troubling unknown, given the wide inter-individual variability in its metabolism. Long-term use. Sepracor, when faced with the fact that Lunesta appeared, on paper, to have no advantages over Ambien or Sonata, went about creating a market niche by showing that Lunesta maintained its effectiveness over six months (Sleep 2003; 26:793-799).