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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
Pupil Dilation And Drug Abuse. Heroin and opioid drugs like morphine and Vicodin cause the pupil of the eyes to constrict. One of the signs of substance abuse with this category of drugs is small pinpoint pupils. The lack of dilation is a possible warning of a serious addiction problem. According to a study in the British Journal of Ophthalmology (1995) there is habituation of the pupils to the drugs. The pupil does adapt and dilation occurs more readily over time.