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The average half-life of Xanax, which means the time it takes the blood to eliminate half of the drug is 11.2 hours (with a range of 6.3 to 26.9 hours). Xanax XR is an extended release version of the drug.
The half-life of Xanax is short, but it can be detected in your system through urine, blood, and hair testing. 1  In the case of repeated use, urine tests can detect Xanax for up to 5-7 days after the last time it was taken. 2  Blood tests can detect Xanax for up to 1-6 days after the last time it was taken.