Evidence for the use of low frequency ultrasound to treat wounds is limited and consists of studies that lack adequate. sample sizes and proper control groups. Additional research with larger trials is needed to demonstrate that low. frequency ultrasound is beneficial for health outcomes in patients with wounds.
The neurotransmitter, acetylcholine, once it has diffused into the synapse, binds to the nicotinic acetylcholine receptors, which are found in the motor end plate. These receptors are ligand-gated ion channels, and once acetylcholine has binded to the receptors, it causes the channels to open.
Research has also shown that one molecule of acetylcholine must bind to each of the two alpha subunits for this central channel to open. Nicotinic receptors at neuromuscular junctions are not the only place in the nervous system where acetylcholine plays a role. It is also active at many other locations, where it can bind to another, very different type of receptor.