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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
A number of therapeutic medications, as well as illicit drugs, may cause dilated pupils including: Amphetamines. Antihistamines such as diphenhydramine (for example, Benadryl, Allermax, Allergia-C) or chlorpheniramine (for example, Chlor-Trimeton, Aller-Chlor, Allerlief). Atropine.