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Hyzaar. Do not use this medicine if you have had an allergic reaction to losartan, hydrochlorothiazide, or a sulfonamide (sulfa drug). Do not use this medicine if you are pregnant or you are not able to urinate. Do not use this medicine together with aliskiren (TekturnaÂ®) if you have diabetes or severe kidney disease.
Losartan, sold under the brand name Cozaar, is used to treat high blood pressure (hypertension). It's also used to lower the risk of stroke in some patients with heart disease.Losartan is an angiotensin receptor blocker (ARB) that blocks a substance that causes blood vessels to tighten.y relaxing blood vessels, losartan helps a person maintain a lower blood pressure, increasing the supply of oxygen and blood to the heart. Losartan is also used to slow long-term kidney damage for people with type 2 diabetes, and it is sometimes used to treat congestive heart failure.