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Hyzaar. Do not use this medicine if you have had an allergic reaction to losartan, hydrochlorothiazide, or a sulfonamide (sulfa drug). Do not use this medicine if you are pregnant or you are not able to urinate. Do not use this medicine together with aliskiren (TekturnaÂ®) if you have diabetes or severe kidney disease.
Both losartan and EXP3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite.