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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
â¦and you can narrow down the type by looking at my pupils. Some drugs, like alcohol and opioids cause the pupils to constrict. Others, like amphetamine, cocaine, LSD and mescaline cause dilated pupils. Police officers know this and some use it as one way of checking if someone is off their face.