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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
Pupil constriction â RightDiagnosis.com. Certain drugs cause constriction of the pupils, such as alcohol and opioids. Other drugs, such as atropine, marijuana, LSD, cocaine, mescaline, psilocybin mushrooms.