In the open-label trial of out- and in-patients with depression who had not responded to adequate monotherapy with two antidepressants, the addition of mirtazapine (15â30 mg/day) to either an SSRI (n= 23) or venlafaxine (n= 12) led to remission in half of the patients.
Other, rare causes of discolored nails include the yellow nail syndrome, an inherited condition that results in slow-growing, yellowing, discolored nails and is associated with lymphedema (swelling of tissues due to the accumulation of fluid) and lung diseases.ails may also appear lightened to a whitish-yellow color if there has been separation of the nail from the nail bed, termed onycholysis. The skin, mucous membranes, and nails may appear blue when there is inadequate oxygenation of blood (cyanosis), but this is not true discoloration of the nail itself.
The Causes of Discolored Toenails. Discolored toe nails may be white, yellow, brown, green, or even black and all of these discolorations may be caused by a nail fungus infection of varying stages.A discolored nail usually starts out with one or more white spots, typically near the edge of the nail, often indicating a fungal infection has begun.iscolored toe nails may be white, yellow, brown, green, or even black and all of these discolorations may be caused by a nail fungus infection of varying stages. A discolored nail usually starts out with one or more white spots, typically near the edge of the nail, often indicating a fungal infection has begun.