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Actress Christina Applegate, diagnosed with breast cancer at age 36 in April 2008, is an example. Applegate first underwent a lumpectomy, but after learning that she had the BRCA genetic mutation (aka the  breast cancer gene ), she opted for a double mastectomy. D Dipasupil/Getty Images Sheryl Crow Sheryl Crow may be best known for her music, but she also has used her celebrity status as a breast cancer survivor to help raise awareness about the importance of early detection. 2  In 2006, she was diagnosed with breast cancer and had a lumpectomy and radiation treatment.
Nearly a decade later, Irish singer-songwriter and Prince cover artist, Sinead O'Connor, took the stage and caused a stir with her smooth pate. Among actresses who've gone bald for the big screen are Sigourney Weaver (Alien 3), Demi Moore (G.I. Jane), and more recently Natalie Portman (V for Vendetta).