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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
Drugs that trigger the release of dopamine, a related neurotransmitter, can also induce mydriasis. Marijuana is a good example. Dopamine cause pupils to dilate by exciting the adrenergic receptors, what in turn increases adrenaline (which the autonomic nervous system is sensitive to). It's important to remember that not all drugs will produce the same degree of pupil dilation.