In the open-label trial of out- and in-patients with depression who had not responded to adequate monotherapy with two antidepressants, the addition of mirtazapine (15â30 mg/day) to either an SSRI (n= 23) or venlafaxine (n= 12) led to remission in half of the patients.
Other, rare causes of discolored nails include the yellow nail syndrome, an inherited condition that results in slow-growing, yellowing, discolored nails and is associated with lymphedema (swelling of tissues due to the accumulation of fluid) and lung diseases.ails may also appear lightened to a whitish-yellow color if there has been separation of the nail from the nail bed, termed onycholysis. The skin, mucous membranes, and nails may appear blue when there is inadequate oxygenation of blood (cyanosis), but this is not true discoloration of the nail itself.
Repeated trauma to toenails, caused by ill-fitting shoes, can lead to deformities in the nails. The deformities may resemble a fungal infection; nails can be thickened or discolored and can lift away from the nail bed, which causes cosmetic concerns. Habits such as nail biting and cuticle biting also can cause trauma to the nails. Nail biting is a main cause of acute paronychia, a type of infection in which bacteria get underneath the tissue at the side of the nail and cause swelling and irritation.