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The narcotic in both medications is the oxycodone, the only difference between the two is the additiâ¦on of Tylenol (aka acetaminophen). The addition of Tylenol does not necessarily make the combo drug more powerful than the straight oxycodone, but is an adjunctive therapy so to speak.
(Tylenol) The only difference is that the Oxycodone-Hcl is pressed into a tablet with Acetaminophen. They are NOT chemically combined, but only mixed together. Oxycodone-Hydrochloride, or Oxycodone-Hcl, is an slightly acidic salt form of the opiate painkiller oxycodone.