In the open-label trial of out- and in-patients with depression who had not responded to adequate monotherapy with two antidepressants, the addition of mirtazapine (15â30 mg/day) to either an SSRI (n= 23) or venlafaxine (n= 12) led to remission in half of the patients.
Other, rare causes of discolored nails include the yellow nail syndrome, an inherited condition that results in slow-growing, yellowing, discolored nails and is associated with lymphedema (swelling of tissues due to the accumulation of fluid) and lung diseases.ails may also appear lightened to a whitish-yellow color if there has been separation of the nail from the nail bed, termed onycholysis. The skin, mucous membranes, and nails may appear blue when there is inadequate oxygenation of blood (cyanosis), but this is not true discoloration of the nail itself.
Injury: 1  Crushing the base of the nail or the nail bed may cause a permanent deformity. 2  Chronic picking or rubbing of the skin behind the nail can cause median nail dystrophy, which gives a lengthwise split or ridged appearance of the thumbnails. 3  Long-term exposure to moisture or nail polish can cause nails to peel and become brittle. Infection: Fungus or yeast cause changes in the color, texture, and shape of the nails. Bacterial infection may cause a change in nail color or painful areas of infection under the nail or in the surrounding skin. Severe infections may cause nail loss. Paronychia is an infection around the nailfold and cuticle. Viral warts may cause a change in the shape of the nail or ingrown skin under the nail. Certain infections (especially of the heart valve) may cause red streaks in the nail bed (splinter hemorrhages). Diseases: