In the open-label trial of out- and in-patients with depression who had not responded to adequate monotherapy with two antidepressants, the addition of mirtazapine (15â30 mg/day) to either an SSRI (n= 23) or venlafaxine (n= 12) led to remission in half of the patients.
Other, rare causes of discolored nails include the yellow nail syndrome, an inherited condition that results in slow-growing, yellowing, discolored nails and is associated with lymphedema (swelling of tissues due to the accumulation of fluid) and lung diseases.ails may also appear lightened to a whitish-yellow color if there has been separation of the nail from the nail bed, termed onycholysis. The skin, mucous membranes, and nails may appear blue when there is inadequate oxygenation of blood (cyanosis), but this is not true discoloration of the nail itself.
Red discoloration under your fingernails can be caused by a number of conditions, some of which could be serious. Talk with your doctor or dermatologist about what may be causing the redness.Some conditions that can lead to a red or brown discoloration under your nails include the following: 1  A splinter hemorrhage.2  This vertical red or brown line under the nail can be caused by an injury, fungal infection, or nail psoriasis, or can be a sign of a heart condition. This vertical red or brown line under the nail can be caused by an injury, fungal infection, or nail psoriasis, or can be a sign of a heart condition. 2  Heart failure. 3  This can cause redness in the white half moon at the bottom of your nail. 4  Kidney disease.