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The average half-life of Xanax, which means the time it takes the blood to eliminate half of the drug is 11.2 hours (with a range of 6.3 to 26.9 hours). Xanax XR is an extended release version of the drug.
Xanax doesnât clear the body as quickly as many other drugs. In fact, Xanax can be detectable in urine for up to 6 weeks in heavy users. Plus, the main ingredient in Xanax (alprazolam) takes a fairly long time to absorb once itâs in the body, so even small doses can be detectable for over a week.anax is absorbed quickly in the body and reaches its peak levels in the blood within one or two hours. These plasma blood levels vary depending on the dose taken, but range from 8-37 ng/mL. The half life of Xanax in healthy adults averages 11 hours. In elderly subjects the half life of Xanax is higher, about 16 hours.