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The average half-life of Xanax, which means the time it takes the blood to eliminate half of the drug is 11.2 hours (with a range of 6.3 to 26.9 hours). Xanax XR is an extended release version of the drug.
How Quickly Does Xanax Leave the Body? This spike in illegal abuse of Xanax led to the creation of tests to detect the drug in peopleâs bodily fluids and tissues. On average, Xanax has an elimination half-life of 9-16 hours. This means that it takes a healthy personâs body this amount of time to get rid of half of a dose of the drug. Therefore, most people will have the substance out of their systems after 4 days. There are a number of factors that can alter the rate that Xanax leaves the body. These include: