In the open-label trial of out- and in-patients with depression who had not responded to adequate monotherapy with two antidepressants, the addition of mirtazapine (15â30 mg/day) to either an SSRI (n= 23) or venlafaxine (n= 12) led to remission in half of the patients.
Other, rare causes of discolored nails include the yellow nail syndrome, an inherited condition that results in slow-growing, yellowing, discolored nails and is associated with lymphedema (swelling of tissues due to the accumulation of fluid) and lung diseases.ails may also appear lightened to a whitish-yellow color if there has been separation of the nail from the nail bed, termed onycholysis. The skin, mucous membranes, and nails may appear blue when there is inadequate oxygenation of blood (cyanosis), but this is not true discoloration of the nail itself.
Fungi are capable of producing many colors, and the species that invade nails and cause a discolored toenail are no exception. In laboratory culture, the so-called dermatophytes are predominantly yellow, mahogany brown, or reddish, while saprophytic fungi that invade nails are often green, black or brown, or colorless.f you notice a discolored toenail, it's best to take care of it right away. See your doctor to confirm that treatment for fungus is a sensible approach, and begin treatment immediately. A fungal nail infection is easier to treat in its early stages.