Two amino acid mutations in MTHFR, the C677T and the A1298C mutations, contribute to the potential for accumulation of homocysteine. The risks for elevated homocysteine are predominantly with the homozygous (two copies) state of each of these mutations, with the A1298 overall being less severe than the C677T mutation.
Necrotizing enterocolitis, usually called NEC, is a condition where the intestines become infected and can begin to die. The disease usually affects premature babies, although term babies may also get NEC. Necrotizing enterocolitis is a serious condition that may require surgery, and has a high morbidity and mortality rate.
colon. the part of the large intestine extending from the cecum to the rectum. It has the same basic design in all species. There is an ascending colon which begins at the cecum, passes forward to the cranial part of the abdominal cavity then crosses to the left side as the transverse colon. It then turns caudally again to become the descending colon. In the caudal abdomen the colon curves to the midline and joins the rectum.