Two amino acid mutations in MTHFR, the C677T and the A1298C mutations, contribute to the potential for accumulation of homocysteine. The risks for elevated homocysteine are predominantly with the homozygous (two copies) state of each of these mutations, with the A1298 overall being less severe than the C677T mutation.
Necrotizing enterocolitis, usually called NEC, is a condition where the intestines become infected and can begin to die. The disease usually affects premature babies, although term babies may also get NEC. Necrotizing enterocolitis is a serious condition that may require surgery, and has a high morbidity and mortality rate.
Systemic necrotizing vasculitis (SNV) is a type of vasculitis that presents with necrosis. An example is giant cell arteritis.ICD-10 uses the variant necrotizing vasculopathy.ystemic necrotizing vasculitis (SNV) is a type of vasculitis that presents with necrosis. An example is giant cell arteritis. ICD-10 uses the variant necrotizing vasculopathy.