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Other signs and symptoms of Prader-Willi syndrome may include: 1  Nearsightedness (myopia) and other vision problems. 2  Light skin and hair compared with other family members. 3  High pain tolerance, making it difficult to identify injury or illness. 4  Problems regulating body temperatures during fever or in hot and cold places.
Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy. Limb weakness with both lower and upper motor neuron signs is almost always evident but less prominent.oth upper and lower motor neurons are affected. Symptoms are usually noticed first in the arms and hands, legs, or swallowing muscles. Approximately 75 percent of people with classic ALS will develop weakness and wasting of the bulbar muscles (muscles that control speech, swallowing, and chewing).