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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
The negative interactions can even occur if grapefruit juice or similar substances are consumed hours before taking the pill, meaning even eating one grapefruit while taking a once-daily medication can have a negative effect.