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Other signs and symptoms of Prader-Willi syndrome may include: 1  Nearsightedness (myopia) and other vision problems. 2  Light skin and hair compared with other family members. 3  High pain tolerance, making it difficult to identify injury or illness. 4  Problems regulating body temperatures during fever or in hot and cold places.
Most people with ALS first feel muscle cramps, spasms or twitching (fasciculations) in one of their arms or legs. Other signs include weakness in the hands and feet or loss of balance. This form of the disease is called limb-onset ALS. About 25% of people with ALS first have trouble talking clearly - slurring words.