Patients were stratified according to tumor PD-L1 status assessed in a central laboratory by immunohistochemical testing (positive vs. negative or indeterminate), BRAF mutation status (V600 mutation-positive vs. wild-type) and American Joint Committee on Cancer stage.[Level of evidence: 1iiA]
Swallowing air excessively; Gastroesophageal reflux; Hiatus hernia; Rapid eating; Intense emotions such as fear, anxiety, excitement, joy, or euphoria [citation needed] Carbonated beverages, alcohol, dry breads, and some spicy foods; Opiate drug use; Laughing; Hiccups may be triggered by a number of common human conditions.
A sudden and involuntary intake of air, producing an unmistakable sound Age, gender, genetics, and lifestyle are not significant factors Almost everyone has occasional attacks of hiccups. Usually, they last for only a few minutes and are no cause for concern. When you have hiccups, the muscles you use in order to breathe in, primarily the diaphragm, contract suddenly, causing a sharp intake of breath. This is interrupted almost immediately by an involuntary closure of the throat, which causes the characteristic sound of a hiccup.