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Winnsboro, South Carolina. Winnsboro is a town in Fairfield County, South Carolina, United States. The population was 3,550 at the 2010 census.[4] It is the county seat of Fairfield County.[5] Winnsboro is part of the Columbia, South Carolina Metropolitan Statistical Area.
Winnsboro is located east of the center of Fairfield County at 34Â°22â²37â³N 81Â°5â²17â³W / 34.37694Â°N 81.08806Â°W / 34.37694; -81.08806 (34.377069, -81.087959). U.S. Route 321 and South Carolina Highway 34 bypass the town on the west side. US 321 Business passes through the center of town on Congress Street.