Blood is mostly made up of water, as are our organs and muscles. To read specifically about edema, swelling caused by fluid retention where excess fluid is trapped in the body's tissues, see our article Edema: Causes, Symptoms and Treatments.
If you use the Amsoil Ea15K01 and the ASM oil (For 3rd gen Prius), then you can safely go 15,000 miles between oil changes. I drive 25,000 miles per year in my Prius. Amsoil backs up their products by a written warranty.
Ford, Volkswagen and Porsche, for example, recommend oil changes every 10,000 miles. So does Toyota on several engines, including the Prius' 1.8-liter four-cylinder and the Camry's 2.5-liter four-cylinder. BMW says owners can go up to 15,000 miles between oil changes (with synthetic oil). The intervals vary by manufacturer and engines, so consult your owner's manual or maintenance schedule to see how often to change the oil in your vehicle and what type of oil to use. You may be surprised.