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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
Sometimes grapefruit interacts with only some of the drugs in a category, not all. For example, you might need to stop taking Zocor or Lipitor, but you might be able to take a different statin. If you have doubts or questions, talk to your doctor about the risks of mixing medications and grapefruit.