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Cholecystokinin is secreted by I-cells in the small intestine and induces contraction of the gall bladder, relaxes the sphincter of Oddi, reduces of gastric acid secretion, increases bile acid production in the liver, delays gastric emptying, and induces digestive enzyme production in the pancreas.
While coffee does not cause gallstone disease, it does cause contractions in the gallbladder. When there is one or more gallstones in the gallbladder at the time of these contractions, it can cause a gallstone attack, making coffee a certainty to avoid if you have gallstone disease.