(April 2014) In law and government, de jure (/deÉª ËdÊÊrÉª/; Latin: de iure, in law) describes practices that are legally recognized by official laws. In contrast, de facto (in fact or in practice) describes situations that are generally known to exist in reality, even if not legally authorized.
Only a portion of them are chromosome abnormalities. Single gene disorders are conditions that are caused by a change in a single gene. Because there are thousands of genes, there are thousands of single gene disorders. This group of disorders cannot be diagnosed by a karyotype.
Although the resolution of chromosomal changes detectable by karyotyping is typically a few megabases, this can be sufficient to diagnose certain categories of abnormalities. For example, aneuploidy, which is often caused by the absence or addition of a chromosome, is simple to detect by karyotype analysis.