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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
On the other hand, a medication that stays in the body too long may build up to potentially dangerous levels. The list of medications that can interact with grapefruit includes commonly prescribed medicines that: Fight infection. Reduce cholesterol. Treat high blood pressure. Treat heart problems.