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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
Warnings labels on prescription bottles should be followed. If an interaction is found to occur, it may be possible that an alternative medication can be prescribed, and the interaction can be avoided. Common drug/grapefruit interactions. Examples of some of the most common or serious grapefruit juice drug interactions: alprazolam; amiodarone; atorvastatin