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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
Grapefruit: Grapefruit and grapefruit juice can interfere with some prescription drugs, and even a few non-prescription drugs. Donât drink grapefruit juice with certain blood pressure-lowering drugs because it can cause higher levels of those medicines in your body, making side effects more likely.