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In the frontal lobes, dopamine plays a role in controlling the flow of information from other areas of the brain. Dopamine disorders in the frontal lobes can cause a decline in neurocognitive function, particularly those linked to the frontal lobes, such as memory, attention and problem solving.
Over the long-term, the amount of dopamine becomes depleted, leading the user to require higher doses to experience the same pleasurable effect. Low dopamine is an inevitable side effect of certain addictions, but is also a consequence of certain conditions like schizophrenia and neurodegenerative diseases.