Viral infections. Rabies (hydrophobia) is a fatal viral disease that can affect any mammal, although the close relationship of dogs with humans makes canine rabies a zoonotic concern. Vaccination of dogs for rabies is commonly required by law. Please see the article dog health for information on this disease in dogs.
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Bisoprolol is a beta-blocker.
Therefore we decided to evaluate the diuretic potentiality of metoprolol. As it was not possible to maintain fixed fluid intake and environmental temperature in patients over several days and as concurrent disease, drug therapy and renal function could affect the results, we decided to perform an animal study.