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Other signs and symptoms of Prader-Willi syndrome may include: 1  Nearsightedness (myopia) and other vision problems. 2  Light skin and hair compared with other family members. 3  High pain tolerance, making it difficult to identify injury or illness. 4  Problems regulating body temperatures during fever or in hot and cold places.
Early symptoms of SCD may include: 1  Painful swelling of the hands and feet, known as dactylitis. 2  Fatigue or fussiness from anemia. 3  A yellowish color of the skin, known as jaundice, or whites of the eyes, known as icteris, that occurs when a large number of red cells hemolyze.