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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
Interactions can happen up to 3 days after eating or drinking grapefruit. This means you cannot drink grapefruit juice in the morning and take your medicines later in the day to stop possible medicine interactions. Do all medicines interact with grapefruit? Not all medicines interact with grapefruit, but many commonly prescribed medicines do. Examples include medicines to treat: High cholesterol: atorvastatin, lovastatin and simvastatin (Note: pravastatin does not interact with grapefruit) High blood pressure: felodipine, nifedipine, nimodipine and nisoldipine.