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From what is known about the causes of Down syndrome, environmental factors and parents' behavioral activity do not seem to play a role. The causes of Down syndrome are genetic problems related to chromosome 21. While Down syndrome is genetic in that it involves an extra chromosome 21, it is not usually hereditary in the conventional sense.
Scientists have successfully turned off the chromosome defect that causes Down syndrome. Down syndrome, also called Trisomy 21, is a genetic condition in which a person has three copies of chromosome 21, resulting in 47 chromosomes instead of 46. It is one of the most common causes of human birth defects. According to the Centers for Disease Control and Prevention, Down syndrome had an incidence rate of 11.8 babies per 10,000 live births from 1999 to 2003.