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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
School of Medicine, Family Medicine answered. If you're on blood pressure medication, you should avoid eating grapefruit. The reason why is that grapefruit is very acidic and breaks down certain medications much faster. For some people, this causes them to absorb too much of the medicine and for others, not enough. Blood pressure medications that are affected by grapefruit juice include calcium channel blockers such as nifedipine.