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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
Some of the riskiest drugs to consume with grapefruit include: 1  Cholesterol-lowering statins, including Lipitor, Zocor, Mevacor and Altoprev. 2  Plavix, an anti-clotting heart/stroke medication. 3  Certain antibiotics.  Calcium channel blockers used to treat high blood 1  pressure. Certain cancer-fighting drugs.