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Cholecystokinin is secreted by I-cells in the small intestine and induces contraction of the gall bladder, relaxes the sphincter of Oddi, reduces of gastric acid secretion, increases bile acid production in the liver, delays gastric emptying, and induces digestive enzyme production in the pancreas.
The intestinal phase of digestion occurs in the duodenum, the first segment of the small intestine. Chyme also stimulates duodenal enteroendocrine cells to release secretin and cholecystokinin. These hormones primarily stimulate the pancreas and gall bladder, but they also suppress gastric secretion and motility.