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These terms cannot be interchanged and have a specific meaning. Efficiency is the ability of an intervention to have effects on a specific marker in relation to a condition without it necessarily been relevant to patients. The study is done under highly controlled conditions with highly compliant participants.
Efficacy: Broadly, efficacy refers to the capacity of a drug to produce an alteration in a target cell/organ after binding to its receptor. A competitive antagonist, that occupies a binding site without producing any alteration in the receptor, is considered to have an efficacy of zero. Efficacy is generally independent of potency/affinity, and is related to the maximum effect that a particular drug is capable of producing.