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Other signs and symptoms of Prader-Willi syndrome may include: 1  Nearsightedness (myopia) and other vision problems. 2  Light skin and hair compared with other family members. 3  High pain tolerance, making it difficult to identify injury or illness. 4  Problems regulating body temperatures during fever or in hot and cold places.
Symptoms of lower motor neuron degeneration include muscle weakness and atrophy, muscle cramps, and fasciculations. To be diagnosed with ALS, people must have signs and symptoms of both upper and lower motor neuron damage that cannot be attributed to other causes.he onset of ALS may be so subtle that the symptoms are overlooked. The earliest symptoms may include fasciculations, cramps, tight and stiff muscles (spasticity), muscle weakness affecting an arm or a leg, slurred and nasal speech, or difficulty chewing or swallowing.