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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
People taking these medicines are advised not to eat grapefruit or drink grapefruit juice at all, because even one glass of juice can have an effect, and the interaction can occur even when the grapefruit or juice is eaten or drunk at a different time.