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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
What To Do. Grapefruit affects a variety of medications, including calcium blockers, cholesterol drugs, anti-anxiety medications and anti-depressive medicines. You may need to avoid grapefruit and fresh grapefruit juice altogether if you take certain drugs.