A design approach is a general philosophy that may or may not include a guide for specific methods. Some are to guide the overall goal of the design. Other approaches are to guide the tendencies of the designer. A combination of approaches may be used if they don't conflict.
Bradycardia can be caused by: 1  Changes in the heart that are the result of aging. 2  Diseases that damage the heart's electrical system. These include coronary artery disease, heart attack, and infections such as endocarditis and myocarditis. 3  Conditions that can slow electrical impulses through the heart.
I am not a doctor, but I am not under the impression that bradycardia can cause long-term health effects. I think the main concern is the danger of having your HR drop so low that you pass out. I remember when my Dad was having bradycardic episodes. The main thing was to get him a pacemaker so he would not pass out.