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Buspirone is a medication used to treat anxiety. Unfortunately, eating a grapefruit while taking buspirone can decrease its effectiveness. MedlinePlus says that buspirone's side effects include vomiting, constipation, trouble breathing, fatigue, nervousness, weakness, numbness, dry mouth and stomach problems.
For this reason, people who take medicines that may interact with grapefruit are usually advised not to eat grapefruit or drink grapefruit juice at all. People may also be advised to avoid other related fruits that could interact with medicines.