Patients were stratified according to tumor PD-L1 status assessed in a central laboratory by immunohistochemical testing (positive vs. negative or indeterminate), BRAF mutation status (V600 mutation-positive vs. wild-type) and American Joint Committee on Cancer stage.[Level of evidence: 1iiA]
Swallowing air excessively; Gastroesophageal reflux; Hiatus hernia; Rapid eating; Intense emotions such as fear, anxiety, excitement, joy, or euphoria [citation needed] Carbonated beverages, alcohol, dry breads, and some spicy foods; Opiate drug use; Laughing; Hiccups may be triggered by a number of common human conditions.
Hiccups occur when a spasm contracts the diaphragm, a large sheet of muscle that separates the chest cavity from the abdominal cavity. This spasm causes an intake of breath that is suddenly stopped by the closure of the vocal cords (glottis). full stomach can be caused by: 1  Eating too much food too quickly. 2  Drinking too much alcohol. 3  Swallowing too much air. 4  Smoking. 5  A sudden change in stomach temperature, such as drinking a hot beverage and then a cold beverage.