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From what is known about the causes of Down syndrome, environmental factors and parents' behavioral activity do not seem to play a role. The causes of Down syndrome are genetic problems related to chromosome 21. While Down syndrome is genetic in that it involves an extra chromosome 21, it is not usually hereditary in the conventional sense.
Â· just now. 1  Down syndrome is caused by a problem with a babyâs chromosomes that happens long before the baby is born. 2  Down syndrome is a chromosomal disorder where an extra copy of chromosome 21 is made, the term is called trisomy 21. 3  It is caused by trisomy, having 3 of the same chromosomes (chromosome 21) One usually have 2 of the same chromosomes, but down syndrome has 3. i a chromosomal disorder caused by the presence of all or part of an extra 21st chromosome. one extra chromosome.