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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
The U.S. FDA has accepted for review a supplemental Biologics Licence Application (sBLA) seeking the approval of Keytruda (pembrolizumab) in combination with Alimta (pemetrexed) and Paraplatin (carboplatin) for patients with metastatic or advanced non-squamous non-small cell lung cancer (NSCLC) without mutations in EGFR or ALK genes.