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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
A person with leg pain has discomfort in the structures of the leg. Leg pain may be caused by an injury, irritation, or inflammation of the skin, muscles, bones, or joints in the leg. Sciatica, or a herniated disk in the lumbar spine, may cause pain that shoots down the leg.