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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
PMS Symptoms & Causes. PMS symptoms usually start 7 to 10 days before menstrual flow begins and end shortly thereafter. PMDD (premenstrual dysphoric disorder) is the term used to describe severe PMS symptoms. This conditions follows the same cycle and range of symptoms, but produces a more debilitating outcome. But even for general PMS, some months PMS symptoms can be worse or better than others. Possible symptoms of PMS include: (3)