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Generally, laboratory mice become sexually mature between fi ve and eight weeks of age. Males of most. strains usually mature sexually by six weeks of age. DBA/2J (000671) and C3H/HeJ (000659) mice are precocious: females can. conceive when they are as young as 23 days old.
Mice *can* get pregnant as early as 4 weeks. However, it is unbelievably hard on them if they do. Never breed your mouse that young, no matter what. In addition, make sure you separate your babies (males from females) at 4 weeks of age so this doesn't happen.It is generally recommended to wait until the female is 12 weeks old or older before she is bred for her first litter.ever breed your mouse that young, no matter what. In addition, make sure you separate your babies (males from females) at 4 weeks of age so this doesn't happen. It is generally recommended to wait until the female is 12 weeks old or older before she is bred for her first litter.