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Two to three days after getting a tuberculin skin test, the size of any bump at the site is measured. 1  Positive, meaning you have been infected with TB bacteria.  Negative, meaning you have not been infected with TB bacteria or your body cannot respond to the protein injected because of a weakened immune system.
A person's negative TB skin test may mean one or more of the following. 1  Person does not have TB infection. 2  Person got the TB infection within last 10-12 weeks, and the TB skin test cannot detect the TB infection. 3  Person has overwhelming TB disease, and the immune system is not responding.