A population PK analysis in patients with major depressive disorder showed no substantial change in plasma concentrations of fluoxetine (20 or 40 mg/day), paroxetine CR (37.5 or 50 mg/day), or sertraline (100 or 150 mg/day) dosed to steady-state.
The definition of advise is to offer a suggestion about what should be done in a situation. A mother warning her child to bring rain boots and an umbrella to an outdoor activity on a day that rain is expected is an example of advise. -Â·visedâ², -Â·visâ²ing. 1  to give advice or an opinion to; counsel. 2  to offer as advice; recommend.  to notify; inform: he was advised of the facts.
verb (used with object), advised, advising. 1. to give counsel to; offer an opinion or suggestion as worth following: I advise you to be cautious. 2. to recommend as desirable, wise, prudent, etc.: He advised secrecy for the sake of national security. 3. to give (a person, group, etc.) information or notice (often followed by of):