A population PK analysis in patients with major depressive disorder showed no substantial change in plasma concentrations of fluoxetine (20 or 40 mg/day), paroxetine CR (37.5 or 50 mg/day), or sertraline (100 or 150 mg/day) dosed to steady-state.
The definition of advise is to offer a suggestion about what should be done in a situation. A mother warning her child to bring rain boots and an umbrella to an outdoor activity on a day that rain is expected is an example of advise. -Â·visedâ², -Â·visâ²ing. 1  to give advice or an opinion to; counsel. 2  to offer as advice; recommend.  to notify; inform: he was advised of the facts.
Taking and giving advice. The central difference between advice and advise is that the spelling advice, with-ice at the end, is the standard English spelling for the noun, but *never* for the verb.