The following are additional Purdue OWL resources to help you write your cover letter: 1  Cover Letter Workshop- Formatting and Organization. 2  Example Employment Documents. 3  Cover Letters 1: Quick Tips. 4  Cover Letters 2: Preparing to Write a Cover Letter. 5  Cover Letter Presentation. 6  Job Search Documents for Working Class Positions.
1 IgG deficiency with hyper-IgM is a disease that results when the B-cell fails to switch from making IgM to IgG. 2  This produces an increase in the amount of IgM antibodies present and a decrease in the amount of IgG antibodies. 3  This disease is the result of a genetic mutation.
IgG2 or IgG3 deficiencies are the most common IgG subclass deficiencies. Since IgG1 comprises 60% of the total IgG level, deficiency of IgG1 usually drops the total IgG level below the normal range, resulting in hypogammaglobulinemia. IgG4 is present in very low levels in children younger than 10 years of age, so IgG4 deficiencies are not usually diagnosed before age 10.