Local Weather; Holiday Weather; Marine Weather; Hill & Mountain Weather; Where's Good Weather
Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Severe symptoms. Women who have severe premenstrual mood swings, depression, irritability, or anxiety (with or without physical symptoms) are said to have premenstrual dysphoric disorder (PMDD). Symptoms generally go away within the first 3 days of menstrual bleeding. This severe type of PMS isn't common.