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Glucosamine and Chondroitin Sulfate Side Effects. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea.ombined with other osteoarthritis treatments (as deemed appropriate by a physician), taking glucosamine and chondroitin sulfate dietary supplements may help some patients attain optimal levels of relief from osteoarthritis-related joint pain.
Some studies have suggested that glucosamine supplements, with or without chondroitin, can reduce arthritis pain, help people with hip or knee arthritis move better, and reduce joint swelling and stiffness, all with few side effects.But in other studies, glucosamine and chondroitin do not seem to help. Stacy Wiegman, PharmD, Pharmacy, answered. Experts don't agree about whether glucosamine and chondroitin help with arthritis. Glucosamine is made naturally in the body, and is important in building cartilage, the cushioning tissue in joints that is lost when arthritis sets in.