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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Thanapathy. Pms symptoms can include feeling tearful, irritability, mood swings, anger, depressed mood, change in sex drive & anxiety.These may be accompanied by swelling of the breasts (or extremities), weight gain, bloating, cramps, overeating, headaches (to include migraines), dizziness, fainting and palpitations.hanapathy. Pms symptoms can include feeling tearful, irritability, mood swings, anger, depressed mood, change in sex drive & anxiety.