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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
Common causes of eczema are allergies secondary to digestive disorders, immune deficiencies, genetic metabolic disorders such as the inability to produce GLA-gamma linoleic acid, a key component in the structure of cell membranes and nutritional deficiencies such as B vitamins (especially niacin and vitamin B6).