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1. of or relating to an interstice or interstices. 2. (Chemistry) physics forming or occurring in an interstice: an interstitial atom. 3. (Chemistry) chem containing interstitial atoms or ions: an interstitial compound. 4. (Biology) anatomy zoology occurring in the spaces between organs, tissues, etc: interstitial cells.
interstitial fluid, an extracellular fluid that fills the spaces between most of the cells of the body and provides a substantial portion of the liquid environment of the body. Formed by filtration through the blood capillaries, it is drained away as lymph.ee nephritis. interstitial fluid pressure. pressure exerted by the free interstitial fluid; if the pressure is negative this tends to suck fluid out of the vascular system and into the tissue space; if the pressure is greater than the intravascular pressure fluid tends to move out of the tissue space.