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Glucosamine and Chondroitin Sulfate Side Effects. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea.ombined with other osteoarthritis treatments (as deemed appropriate by a physician), taking glucosamine and chondroitin sulfate dietary supplements may help some patients attain optimal levels of relief from osteoarthritis-related joint pain.
Reviewing this information as a whole, it appears that glucosamine chondroitin sulfate is safe to administer to patients with shellfish allergy, but the data that support this contention is based on a small number of patients.here is very reassuring data in two studies (albeit small) that the administration of glucosamine chondroitin sulfate is safe in patients with shellfish allergy (see abstract by Villacis J, et al. and the reference by Gray which are copied below).