The use of Ribavirin to treat chronic hepatitis C in patients receiving azathioprine has been reported to induce severe pancytopenia and may increase the risk of azathioprine-related myelotoxicity. Inosine monophosphate dehydrogenase (IMDH) is required for one of the metabolic pathways of azathioprine.
There are several common underlying causes of kidney disease. 1  In older cats Interstitial Nephritis is most frequently seen. 2  Polycystic Kidney Disease (PKD) is a very common problem in Persian cats - 20-30% of them can be affected. 3  Tumours are occasionally seen in middle-aged and older cats.
Many renal diseases result in CRF. Usually the diagnosis in the vetâs office is simply CRF because the cause cannot be determined in most cases. Causes can, however, be divided into two groups â congenital and acquired. Congenital kidney disease may progress and turn into CRF in kittens and younger cats.