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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Pain radiating down the leg: Leg pain can be due to a muscle cramp. See detailed information below for a list of 27 causes of Pain radiating down the leg, Symptom Checker, including diseases and drug side effect causes.