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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
But until we see the results of this trial, and in the absence of actual evidence that afatinib is convincingly more effective than Tarceva and Iressa, afatinib just represents a more toxic version of these other drugs for first line therapy in. mutated patients with advanced.