Definition of solubility. 1) The amount of a solute that will dissolve in a specific solvent under given conditions.
The small intestine is where most chemical digestion takes place. Most of the digestive enzymes in the small intestine are secreted by the pancreas and enter the small intestine via the pancreatic duct. These enzymes enter the small intestine in response to the hormone cholecystokinin, which is produced in response to the presence of nutrients.
1 The main function of the pancreas is to secrete hormones and enzymes that help with digestion and regulate blood sugar (glucose) metabolism.  The digestive enzymes are released via the pancreatic duct into the small intestine where they are activated to help break down fats and proteins.