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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
So, tell a doctor immediately if you have PMR and you develop any of the following symptoms: 1  Headache or tenderness on one side of your head. 2  Pain in your jaw when you chew which eases quickly when you rest the jaw muscles. 3  Sudden loss of vision, or any other sudden visual problem in one or both eyes.