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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Fast Facts. 1  The typical polymyalgia rheumatica symptoms (what you feel) of PMR are aching and stiffness about the upper arms, neck, lower back and thighs. 2  These symptoms develop quickly and are worse in the morning. 3  Polymyalgia rheumatica symptoms respond promptly to low doses of corticosteroids, but may recur as the dose is lowered. Polymyalgia rheumatica (sometimes referred to as PMR) is a common cause of widespread aching and stiffness that affects adults over the age of 50, especially Caucasians. Because polymyalgia rheumatica does not often cause swollen joints, it may be hard to recognize. It may occur with another health problem, giant cell arteritis.