Symptoms of Hashimoto's Thyroiditis: Introduction. The types and severity of symptoms of Hashimoto's disease vary between individuals. Many people have no symptoms at all. If Hasimoto's disease leads to hypothyroidism, symptoms of an underactive thyroid may develop. At the onset of hypothyroidism, symptoms can be vague and develop slowly. They may not include weakness, weight gain, cold sensitivity, cold hands and feet, fatigue, dry skin, brittle nails, and thinning, brittle hair.
Ligand Binding Assays (LBA) is an assay, or an analytic procedure, whose procedure or method relies on the binding of ligand molecules to receptors, antibodies or other macromolecules.on specific binding refers to the binding of a ligand to something other than its designated receptor such as various other receptors, or different types of transporters in the cell membrane. For example, various antagonists can bind to multiple types receptors.
All four-Cl ligands get arranged in tetrahedral manner around the central metal ion and form a metal complex. Ligand can be an anion, cation or a neutral molecule. Neutral ligands must have a lone pair of electrons which can be donated to the metal atom or ion to form complexes. ligand can be defined as a specific substance that is capable of binding and forming a thermodynamically stable complex with other bio molecules through either ionic and hydrogen bonding or Van der Waals forces to perform a specific biologically important function.