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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Premenstrual syndrome (PMS) facts. 1  Premenstrual syndrome (PMS) is a set of specific physical and psychological features. 2  Physical symptoms of PMS include breast tenderness and bloating. 3  Psychological changes or PMS may include anger and depression.  PMS occurs in the last half of a woman's menstrual cycle.