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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Leg pain can occur in the foot, ankle, knee, behind the knee, thigh, down the back of the leg, or in any part of the leg. It can occur at night, while lying down, or while running or exercising, depending upon the cause. Depending on the cause, leg pain can occur in one leg only or in both legs. Typically, the leg pain is a result of tissue inflammation that is caused by injury or disease. Either injury or chronic disease can cause inflammation to any of the tissues of the leg and lead to leg pain. Since the leg contains a number of different structures and tissue types, a wide variety of conditions and injuries can cause leg pain. Depending on the cause of the pain, other symptoms, like. weakness, numbness, throbbing, cramps, aching, or; a tingling sensation, may accompany leg pain.