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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Generally, leg pain refers to any pain that develops between your feet and your pelvis. To make matters even more complicated, the cause of leg pain may not even be due to a problem with your leg. For example, some spine disorders can cause leg pain. Leg pain may be acute or chronic. Onset may be sudden or gradual.