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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
PMS symptoms - Symptoms of PMS vary in every woman and in every cycle, ranging from mild to moderate to severe. Some women feel that these symptoms are worsened in times of increased physical or emotional stress. There are more than a hundred symptoms linked to PMS, but the most common ones include: