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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
This intensity and timeframe are how a woman can know if it is pms depression rather than clinical. Still there is a lot of distress that goes with PMDD for any woman. In addition to depression a woman might also experience other mood swings and emotional changes such as anger, anxiety and fatigue and irritability.