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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
Eczema Causes. Doctors don't know exactly what causes eczema. The most common type of eczema -- atopic dermatitis -- resembles an allergy. But the skin irritation, which is more often seen in children rather than adults, is not an allergic reaction.he Role of Triggers in Eczema. A trigger is not something that causes eczema. But it can cause it to flare or make a flare worse. The most common triggers are substances that irritate the skin.