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Generally, laboratory mice become sexually mature between fi ve and eight weeks of age. Males of most. strains usually mature sexually by six weeks of age. DBA/2J (000671) and C3H/HeJ (000659) mice are precocious: females can. conceive when they are as young as 23 days old.
Female mice are only receptive to male mice while they are in estrus. Mating generally occurs within 24 hours of introducing a male and an 'in estrus' female mouse, though the female is most receptive during the first few hours. There may be frequent, short copulations before adequate intromission and ejaculation occur.