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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Men identified several PMS-related symptoms as signs of their man periods, such as constant hunger to general irritability. Males (12 percent) confessed they were more sensitive about personal weight, while some (5 percent) suffered from menstrual cramps..