A population PK analysis in patients with major depressive disorder showed no substantial change in plasma concentrations of fluoxetine (20 or 40 mg/day), paroxetine CR (37.5 or 50 mg/day), or sertraline (100 or 150 mg/day) dosed to steady-state.
The definition of advise is to offer a suggestion about what should be done in a situation. A mother warning her child to bring rain boots and an umbrella to an outdoor activity on a day that rain is expected is an example of advise. -Â·visedâ², -Â·visâ²ing. 1  to give advice or an opinion to; counsel. 2  to offer as advice; recommend.  to notify; inform: he was advised of the facts.
To give an opinion or recommend a plan or course of action; to give notice; to encourage, inform, or acquaint. Advise does not mean the same as instruct or persuade. If a statute authorized a trial court to acquit, the court has no power to instruct the jury to acquit. The court can only counsel, and the jury is not bound by the advice. advise. Foreign phrases: Consilia multorum quaeruntur in magnis.The advice of many are required in af fairs of magnitude.