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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Causes of Leg Pain Video. Many conditions can cause leg pain and foot pain. Commonly, the main cause of the symptoms has its origin in the lower back, which is where the nerves branch out from the spine to provide function to the muscles in the leg, ankle, and foot. See Getting an Accurate Back Pain Diagnosis