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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Chances are good that youâve had some type of premenstrual syndrome since you started your period. Doctors think as many as three-quarters of menstruating women have some signs of PMS, whether itâs food cravings, cramps, tender breasts, moodiness, or fatigue. But premenstrual dysphoric disorder (PMDD) is different. It causes emotional and physical symptoms, like PMS, but women with PMDD find their symptoms debilitating, and they often interfere with their daily lives, including work, school, social life, and relationships. Researchers donât know the exact cause of PMDD.