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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
The most frequent physical signs and symptoms of PMS include: 1  fatigue, 2  bloating (due to fluid retention), 3  weight gain, 4  breast tenderness, 5  acne, 6  sleep disturbances with sleeping too much or too little (insomnia), and.  appetite changes with overeating or food cravings.