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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
What are the symptoms of polymyalgia rheumatica (PMR)? Print, Download, Order. If you have polymyalgia rheumatica (PMR) youâll usually have severe and painful stiffness, which is often worse in the morning, especially in your shoulders and thighs and usually affecting both sides. PMR often strikes suddenly, appearing over a week or two and sometimes just after a flu-like illness.