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1. of or relating to an interstice or interstices. 2. (Chemistry) physics forming or occurring in an interstice: an interstitial atom. 3. (Chemistry) chem containing interstitial atoms or ions: an interstitial compound. 4. (Biology) anatomy zoology occurring in the spaces between organs, tissues, etc: interstitial cells.
the extracellular fluid bathing cells in most tissues, excluding the fluid within the lymph and blood vessels. interstitial gland. of the ovary, consisting of polyhedral epithelioid cells in the stroma of the ovary and have characteristics of cells which produce steroids. interstitial nephritis. see nephritis.