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Photo Therapeutic Keratectomy-PTK Laser eye surgery. PTK is a surgical procedure which is mainly used to treat scars on the cornea and any other type of corneal surface disease.These include corneal dystrophy and epithelial erosion syndrome.he aim of this procedure is to treat surface level corneal disease and NOT to remove the need to wear glasses or contact lenses. However, this treatment can be combined with PRK which means that it has both a medical and cosmetic application.
The endoplasmic reticulum (ER) resident PKR-like kinase (PERK) is necessary for Akt activation in response to ER stress. We demonstrate that PERK harbors intrinsic lipid kinase, favoring diacylglycerol (DAG) as a substrate and generating phosphatidic acid (PA). This activity of PERK correlates with activation of mTOR and phosphorylation of Akt on Ser473. PERK lipid kinase activity is regulated in a phosphatidylinositol 3-kinase (PI3K) p85Î±-dependent manner. Moreover, PERK activity is essential during adipocyte differentiation.