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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Leg Pain Causes. Pain in the legs can occur as a result of conditions that affect bones, joints, muscles, tendons, ligaments, blood vessels, nerves, and skin. Typically, the pain is a result of tissue inflammation that is caused by injury or disease.