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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
Atopic dermatitis or eczema. Atopic dermatitis, or eczema, causes the skin to itch, scale, swell, and sometimes blister. This type of eczema usually runs in families and is often associated with allergies, asthma, and stress.topic dermatitis, or eczema, causes the skin to itch, scale, swell, and sometimes blister. This type of eczema usually runs in families and is often associated with allergies, asthma, and stress.