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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
Eczema is not directly caused by an autoimmune disorder, but some forms have been associated with such disorders. Atopic dermatitis, the most common type of eczema, stems from an immune system imbalance.Researchers have determined that people with atopic dermatitis have low levels of a protein needed to promote healthy immune system function. This makes your skin more susceptible to infection and unable to prevent inflammation.topic dermatitis, the most common type of eczema, stems from an immune system imbalance. Researchers have determined that people with atopic dermatitis have low levels of a protein needed to promote healthy immune system function. This makes your skin more susceptible to infection and unable to prevent inflammation.