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Glucosamine and Chondroitin Sulfate Side Effects. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea.ombined with other osteoarthritis treatments (as deemed appropriate by a physician), taking glucosamine and chondroitin sulfate dietary supplements may help some patients attain optimal levels of relief from osteoarthritis-related joint pain.
1 Studies have found that glucosamine and chondroitin supplements may interact with the anticoagulant (blood-thinning) drug warfarin (Coumadin). 2  Overall, studies have not shown any other serious side effects.nly a small amount of research has been done on glucosamine and chondroitin for osteoarthritis of joints other than the knee and hip. Because there have been only a few relatively small studies, no definite conclusions can be reached. More information. 1  Chondroitin for osteoarthritis of the hand.