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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
Afatinib is an oral, once daily targeted treatment which works by irreversibly blocking the ErbB family of receptors. The ERBB3 tyrosine kinase is activated by neuregulins (NRGs) or other ERBB and non-ERBB kinases and it connects to the downstream PI3K/AKT/ MAPK mitogenic pathway.