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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Leg pain is any type of pain or discomfort in the leg, from the hip joint to the heels. Leg pain is a fairly common complaint. Your legs are made up of joints, muscles, tendons, ligaments, nerves and blood vessels all of which are subject to injury, infection or other conditions that can cause leg pain. Leg pain may last briefly or be constant, and affect your entire leg or only a particular area. Your pain may feel achy, piercing or tingling.