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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
And many patients and physician talk about atopic dermatitis and eczema as the same thing. Eczema is caused by a variety of factors. Certainly genetic factors and people from allergic families will have more problems with eczema.Other things that cause eczema can be contact with the skin. One form of eczema is contact dermatitis.nd many patients and physician talk about atopic dermatitis and eczema as the same thing. Eczema is caused by a variety of factors. Certainly genetic factors and people from allergic families will have more problems with eczema.