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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
1 Eczema is a skin condition that causes itchy, red, and swollen patches of skin. 2  The most common type is called atopic dermatitis. 3  Everyday things in your environment â cigarette smoke, pollen, and even your clothes â can cause eczema to flare. Eczema is a skin condition that causes itchy, red, and swollen patches of skin. 2  The most common type is called atopic dermatitis. 3  Everyday things in your environment â cigarette smoke, pollen, and even your clothes â can cause eczema to flare.