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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
The chemotherapy drugs carboplatin and etoposide are often used to treat extensive small cell lung cancer. But the cancer can start to grow again. When this happens it is more difficult to treat. In this trial researchers looked at a drug called ipilimumab as well as chemotherapy. Ipilimumab is a type of biological therapy called a monoclonal antibody. It targets cancer cells by looking for a particular protein on the surface called CTLA-4. Ipilimumab stops CTLA-4 from switching off part of the immune system.