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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Your doctor will also want to make sure you don't have one of the following conditions that shares symptoms with PMS: 1  Depression. 2  Anxiety. 3  Menopause. Chronic fatigue syndrome (CFS)  Irritable bowel syndrome 1  (IBS) Problems with the endocrine(EN-doh-kryn) system, which makes hormones.