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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Report Abuse. Yes: PMS symptoms include: * Fatigue: This is the most common symptom of PMS. Women with PMS may feel so tired they can barely get through the day. Some women also may have trouble sleeping at night. * Tension and irritability: A woman with PMS may feel very on edge. Small annoyances seem huge.