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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
Targeted therapies may also be described as chemotherapy or non-cytotoxic chemotherapy, as chemotherapy strictly means only treatment by chemicals. But in typical medical and general usage chemotherapy is now mostly used specifically for traditional cytotoxic chemotherapy. Bevacizumab (marketed as Avastin) targets circulating VEGF ligand. 2  It is approved for use in the treatment of colon cancer, breast cancer, non-small cell lung cancer, and is investigational in the treatment of sarcoma. 3  Its use for the treatment of brain tumors has been recommended.