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Antipsychotics. Antipsychotic medicines, also known as neuroleptics, are usually recommended as the first treatment for psychosis. They work by blocking the effect of dopamine (a chemical that transmits messages in the brain). However, they're not suitable or effective for everyone, as side effects can affect people differently.
However, a number of medications approved for the treatment of other mental health conditions also may be helpful for schizoaffective disorder. These medications include: 1  Antipsychotics. 2  Doctors prescribe these medications to treat psychotic symptoms, such as delusions, paranoia and hallucinations.