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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
The most common type of eczema -- atopic dermatitis -- resembles an allergy. But the skin irritation, which is more often seen in children rather than adults, is not an allergic reaction. The current thinking is that eczema is caused by a combination of factors that include: 1  Genetics. 2  Abnormal function of the immune system. 3  Environment. 4  Activities that may cause skin to be more sensitive. 5  Defects in the skin barrier that allow moisture out and germs in.