The following are additional Purdue OWL resources to help you write your cover letter: 1  Cover Letter Workshop- Formatting and Organization. 2  Example Employment Documents. 3  Cover Letters 1: Quick Tips. 4  Cover Letters 2: Preparing to Write a Cover Letter. 5  Cover Letter Presentation. 6  Job Search Documents for Working Class Positions.
1 IgG deficiency with hyper-IgM is a disease that results when the B-cell fails to switch from making IgM to IgG. 2  This produces an increase in the amount of IgM antibodies present and a decrease in the amount of IgG antibodies. 3  This disease is the result of a genetic mutation.
The IgG class of antibodies is composed of four different subtypes of IgG molecules called the IgG subclasses. These are designated IgG1, IgG2, IgG3 and IgG4. Patients with persistently low levels of one or two IgG subclasses and a normal total IgG level have a selective IgG subclass deficiency. While all the IgG subclasses contain antibodies to components of many disease-causing bacteria and viruses, each subclass serves a slightly different function in protecting the body against infection.