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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
1 Eczema is not a single disease but a reaction pattern of the skin produced by a number conditions. 2  Atopic dermatitis, a common causes of eczema, is more prevalent in those with asthma and hay fever. 3  Eczema appears as small blisters that can weep and ooze, or as crusted, thickened plaques of skin.