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Generally, laboratory mice become sexually mature between fi ve and eight weeks of age. Males of most. strains usually mature sexually by six weeks of age. DBA/2J (000671) and C3H/HeJ (000659) mice are precocious: females can. conceive when they are as young as 23 days old.
The period during which the female is receptive to the male and allows breeding is about 12 hours and usually occurs at night. Female mice can come back into heat within l4-28 hours after giving birth to a litter.