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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
1 Many causes of leg pain are obvious, such as injury after an accident. 2  Leg pain can have less obvious causes, such as peripheral artery disease. 3  Repetitive, excessive sports, especially in the form on running, can lead to trauma that creates leg pain-E.G: shin splints and stress fractures. Repetitive, excessive sports, especially in the form on running, can lead to trauma that creates leg pain-E.G: shin splints and stress fractures. 2  Leg pain with an underlying medical cause may be nerve-related, musculoskeletal or vascular.