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1. of or relating to an interstice or interstices. 2. (Chemistry) physics forming or occurring in an interstice: an interstitial atom. 3. (Chemistry) chem containing interstitial atoms or ions: an interstitial compound. 4. (Biology) anatomy zoology occurring in the spaces between organs, tissues, etc: interstitial cells.
Interstitial lung disease includes a group of diseases that have thickening of the supporting tissues between the air sacs of the lungs as the common factor. The interstitium is a thin layer of tissue that is normally appears as a fine lace on X-rays or imaging studies (best visualized as the appearance of a sponge).