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Antipsychotics. Antipsychotic medicines, also known as neuroleptics, are usually recommended as the first treatment for psychosis. They work by blocking the effect of dopamine (a chemical that transmits messages in the brain). However, they're not suitable or effective for everyone, as side effects can affect people differently.
Psychotherapy appears to be one of the only methods to treat a person suffering from pathological lying. No research has been performed regarding the use of pharmaceutical medication to treat pathological liars. Some research suggests that certain people may have a predisposition to lying.