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Glucosamine and Chondroitin Sulfate Side Effects. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea.ombined with other osteoarthritis treatments (as deemed appropriate by a physician), taking glucosamine and chondroitin sulfate dietary supplements may help some patients attain optimal levels of relief from osteoarthritis-related joint pain.
In the past, researchers have found that some chondroitin supplements did not contain the amount of chondroitin stated on the label. The same was true of some combination glucosamine and chondroitin supplements. Ask your doctor to recommend a brand, or choose a brand you trust.