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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Diagnostic Criteria for Premenstrual Dysphoric Disorder or PMDD. PMDD is a severe form of PMS that includes severe symptoms of depression, anxiety, and irritability before menstruation begins. These symptoms must occur during the last week before menstruation starts.