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1. of or relating to an interstice or interstices. 2. (Chemistry) physics forming or occurring in an interstice: an interstitial atom. 3. (Chemistry) chem containing interstitial atoms or ions: an interstitial compound. 4. (Biology) anatomy zoology occurring in the spaces between organs, tissues, etc: interstitial cells.
Interstitial nephritis is a kidney disorder in which the spaces between the kidney tubules become swollen (inflamed). This can cause problems with the way your kidneys work. Interstitial nephritis may be temporary (acute), or it may be long-lasting (chronic) and get worse over time. The acute form of interstitial nephritis is most often caused by side effects of certain drugs. The following can cause interstitial nephritis: Allergic reaction to a drug (acute interstitial allergic nephritis).