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A bundle branch block is a defect of the bundle branches or fascicles in the electrical conduction system of the heart. bundle branch block is a defect of the bundle branches or fascicles in the electrical conduction system of the heart.
1 Bundle Branch Block: An electrical fault in the heart where the electrical signals are blocked or slowed as they try to enter the bundle branches.  Bundle Branch Block is listed as a rare disease by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).