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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Cramps. A principle cause of leg pain is a cramp or muscle spasm, often known as a charley horse. Muscle fatigue, dehydration, and some medicationsâsuch as diuretics and statinsâcan all lead to leg cramps.eg pain refers to pain or discomfort anywhere in the leg. It can range from a dull ache to an intense stabbing sensation. There are many causes of leg pain. However, only some of these are medically serious.