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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
1 Eczema is likely related to conditions that adversely affect the skin's barrier function (including genetic factors, nutrient deficiencies, bacterial infection, and dry, irritated skin). 2  9. 3  Stress and other emotional factors do not cause atopic dermatitis, but they can make the condition worse. 4  2.