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Generally, laboratory mice become sexually mature between fi ve and eight weeks of age. Males of most. strains usually mature sexually by six weeks of age. DBA/2J (000671) and C3H/HeJ (000659) mice are precocious: females can. conceive when they are as young as 23 days old.
A mating pair of rats can have 5 litters of 7-15 pups in a year, and the pups themselves become fertile around 5 weeks of age. In a vacuum environment, such a pair could theoretically produce hundreds of thousands if not millions of descendants in a single year.