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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Key Facts. 1  PMS symptoms usually begin the week before a menstrual period. 2  Common symptoms of PMS: mood swings, breast soreness, bloating, acne, cravings for certain foods, and fatigue. 3  PMS is treated with lifestyle changes and sometimes medication.he most common symptoms include: mood swings, breast soreness, bloating, acne, cravings for certain foods, increased hunger and thirst, and fatigue. Other symptoms may include constipation or diarrhea, irritability, and feeling blue or down in the dumps.