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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Leg pain can come from a variety of causes. Your health care professional has specific ways to discover if the cause is P.A.D. Other non-P.A.D. common causes of leg pain may include: Deep vein thrombosis (DVT), which occurs when a blood clot (thrombus) forms in the larger veins of the area. This clot can interfere with blood flow, and it may break off and travel through the bloodstream (embolize).