The use of Ribavirin to treat chronic hepatitis C in patients receiving azathioprine has been reported to induce severe pancytopenia and may increase the risk of azathioprine-related myelotoxicity. Inosine monophosphate dehydrogenase (IMDH) is required for one of the metabolic pathways of azathioprine.
There are several common underlying causes of kidney disease. 1  In older cats Interstitial Nephritis is most frequently seen. 2  Polycystic Kidney Disease (PKD) is a very common problem in Persian cats - 20-30% of them can be affected. 3  Tumours are occasionally seen in middle-aged and older cats.
Acute renal failure is more common in younger cats than the chronic form. Chronic kidney failure is more insidious. Though the exact causes are uncertain, chronic kidney failure is the result of an accumulation of injuries to the nephrons, which are the functional units of the kidney.