Symptoms of Hashimoto's Thyroiditis: Introduction. The types and severity of symptoms of Hashimoto's disease vary between individuals. Many people have no symptoms at all. If Hasimoto's disease leads to hypothyroidism, symptoms of an underactive thyroid may develop. At the onset of hypothyroidism, symptoms can be vague and develop slowly. They may not include weakness, weight gain, cold sensitivity, cold hands and feet, fatigue, dry skin, brittle nails, and thinning, brittle hair.
Ligand Binding Assays (LBA) is an assay, or an analytic procedure, whose procedure or method relies on the binding of ligand molecules to receptors, antibodies or other macromolecules.on specific binding refers to the binding of a ligand to something other than its designated receptor such as various other receptors, or different types of transporters in the cell membrane. For example, various antagonists can bind to multiple types receptors.
Efficacy spectrum of receptor ligands. An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response. Whereas an agonist causes an action, an antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist.ypes of agonists [edit]. Receptors can be activated by either endogenous (such as hormones and neurotransmitters) or exogenous (such as drugs) agonists, resulting in a biological response.