The use of Ribavirin to treat chronic hepatitis C in patients receiving azathioprine has been reported to induce severe pancytopenia and may increase the risk of azathioprine-related myelotoxicity. Inosine monophosphate dehydrogenase (IMDH) is required for one of the metabolic pathways of azathioprine.
There are several common underlying causes of kidney disease. 1  In older cats Interstitial Nephritis is most frequently seen. 2  Polycystic Kidney Disease (PKD) is a very common problem in Persian cats - 20-30% of them can be affected. 3  Tumours are occasionally seen in middle-aged and older cats.
The main causes of bone marrow suppression in cats include: 1  Any severe or chronic disease (such as chronic kidney or liver disease) 2  Very poor nutrition or nutritional imbalances. 3  Autoimmune disease.  Feline leukemia virus 1  (FeLV) Feline immunodeficiency virus 2  (FIV) Chemicals or toxins.  Neoplasia (cancer)