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Glucosamine and Chondroitin Sulfate Side Effects. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea.ombined with other osteoarthritis treatments (as deemed appropriate by a physician), taking glucosamine and chondroitin sulfate dietary supplements may help some patients attain optimal levels of relief from osteoarthritis-related joint pain.
2) Chondroitin Sulfate: This is used with glucosamine, helps build the cartilage, and prevents pain in thejoints. If chondroitin sulfate and glucosamine are taken in conjunction as supplements for joint pain, the pain may be abated and the joints may become stronger.he ten best supplements that fight joint pain are: 1) Glucosamine: This is one of the best supplements for knee joints. This fatty acid is a part of cartilage and other components of the joints.