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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
PMS Symptoms but No Period. Many women experience premenstrual symptoms as a natural part of their regular menstrual cycles. Each woman, however, experiences these symptoms in different degrees. Some women have mild symptoms or none at all, while others have moderate to severe symptoms that may disrupt their work or daily activities.