Medical Definition of HYPHA. : one of the threads that make up the mycelium of a fungus, increase by apical growth, and are coenocytic or transversely septate.efinition of HYPHA. : one of the threads that make up the mycelium of a fungus, increase by apical growth, and are transversely septate or nonseptate. â hyÂ·phal \-fÉl\ adjective. See hypha defined for kids. ADVERTISEMENT.
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