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Two to three days after getting a tuberculin skin test, the size of any bump at the site is measured. 1  Positive, meaning you have been infected with TB bacteria.  Negative, meaning you have not been infected with TB bacteria or your body cannot respond to the protein injected because of a weakened immune system.
A two-step skin test is the administration and reading of two TSTs typically placed 1-3 weeks apart. According to CDC guidelines if two TB tests are completed within 12 months, this can be considered a valid two-step TB skin test.* There are two options for conducting two-step testing: 1.