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Underlying Medical Causes of Urine Odor. Several conditions can cause strong or unusual urine odor. The most common causes include: Dehydration. Dehydration occurs when you do not drink enough fluids. If you are dehydrated, you may notice that your urine is a dark yellow or orange color and smells like ammonia.
Urine is laden with urea, a byproduct of protein metabolism. Urea is related to ammonia and is the main reason why our urine has an ammonia-like odor. There are several other substances that are in human urine which can also contribute to its odor. Concentrated urine as a result of dehydration means that solutes such as urea are in a higher concentration.