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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
Symptoms of PMS: Mood Swings. For many women, the worst part of PMS is its unpredictable impact on mood. Irritability, anger, crying spells, depression, and anxiety may come and go in the days leading up to your period.Some women even have trouble with memory and concentration during this time.ymptoms of PMS: Mood Swings. For many women, the worst part of PMS is its unpredictable impact on mood. Irritability, anger, crying spells, depression, and anxiety may come and go in the days leading up to your period.