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Researchers say consumption of artificial sweeteners such as saccharin, sucralose and aspartame led to increased risk of glucose intolerance, a condition linked to diabetes. Sweet âN Low contains saccharin. Equal original contains aspartame. Splenda contains sucralose.
Healthy Eating. Artificial sweeteners have been on the market for a long time, but there are still not enough long-term studies to determine safety and side effects of continued use. High-intensity sweeteners, also commonly referred to as artificial sweeteners, are substitutes or alternatives to sugar.