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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
Immunotherapy of cancer is changing the outlook for many advanced cancers previously thought poorly treatable and incurable. The immunotherapies widely available today are the check point inhibitors. These are antibodies that unlink PD-1 and PDL-1, the proteins that mask the cancer from the immune system.