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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Pain in the legs may be due to injury or inflammation of any of the structures that are found in the leg, including bones, joints, muscles, tendons, ligaments, blood vessels, nerves, and skin. Inflammation of tissue is usually the cause of pain. Pain can also radiate from other parts of the body and be felt in the leg. Back ailments can cause pain and numbness of the leg. Abdominal aorta and iliac artery aneurysms can also present with leg pain. A blood clot in the large veins located in the abdomen, pelvis, or legs is another cause of leg symptoms.