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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
List of causes of Dermatitis. Following is a list of causes or underlying conditions (see also Misdiagnosis of underlying causes of Dermatitis) that could possibly cause Dermatitis includes: 1  Numerous underlying causes are possible. 2  Certain infections (see Infection). 3  Certain toxins or chemicals. 4  Allergic reaction.