Local Weather; Holiday Weather; Marine Weather; Hill & Mountain Weather; Where's Good Weather
Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
To be diagnosed with PMDD, a woman must have at least five of the following symptoms around the time of her period: 1  Deep sadness or despair, with possible suicidal thoughts. 2  Lasting irritability and anger, which may include frequent outbursts at loved ones. 3  Feelings of tension or anxiety. 4  Panic attacks. 5  Mood swings. 6  Crying.