The use of Ribavirin to treat chronic hepatitis C in patients receiving azathioprine has been reported to induce severe pancytopenia and may increase the risk of azathioprine-related myelotoxicity. Inosine monophosphate dehydrogenase (IMDH) is required for one of the metabolic pathways of azathioprine.
There are several common underlying causes of kidney disease. 1  In older cats Interstitial Nephritis is most frequently seen. 2  Polycystic Kidney Disease (PKD) is a very common problem in Persian cats - 20-30% of them can be affected. 3  Tumours are occasionally seen in middle-aged and older cats.
Initial Evaluation. Most cats that are feeling and showing symptoms of chronic renal failure (CRF) are very sick and already have lost about 70% of their kidney function. The veterinarian will be presented with an older cat who âainât doinâ rightâ (called âADRâ in veterinary lingo).