Sciatica causes pain that begins in the lower back and spreads through the buttock, leg, calf and, occasionally, the foot. The pain generally will feel dull, aching or burning. Sometimes, it starts gradually, worsens during the night, and is aggravated by motion. Sciatica also can cause tingling, numbness or muscle weakness in the affected leg.
A callus (or callosity) is a toughened area of skin which has become relatively thick and hard in response to repeated friction, pressure, or other irritation.Rubbing that is too frequent or forceful will cause blisters rather than allow calluses to form.oo much friction occurring too fast for the skin to develop a protective callus will cause a blister or abrasion instead. Biologically, calluses are formed by the accumulation of terminally undifferentiated keratinocytes in the outermost layer of skin.
Next, a soft callus made mostly of collagen is created around the fracture by another special group of cells called chondroblasts. This stage can last anywhere from 4 days to 3 weeks. A hard callus forms next as osteoblast cells create new bone, adding minerals to make it hard. This stage typically begins 2 weeks after the break, and ends somewhere between the 6th and 12th week. Lastly, the bone is remodeled.