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The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier.2  A gene variation that affects the skin's barrier function.ealthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors: 1  Dry, irritable skin, which reduces the skin's ability to be an effective barrier. 2  A gene variation that affects the skin's barrier function.
1 Burns, if severe enough, can produce blistering. 2  This includes burns from heat, chemicals, and sunburns. 3  Allergic eczema is a skin condition that is caused or worsened by allergens and can produce blisters. 4  Another type of eczema, dyshidrotic eczema, also causes blistering, but its cause is unknown.ore rarely, blisters are the result of a skin condition. For many of these rare conditions, the cause is unknown. A few skin conditions that cause blisters include: 1  porphyrias. 2  pemphigus.