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1. of or relating to an interstice or interstices. 2. (Chemistry) physics forming or occurring in an interstice: an interstitial atom. 3. (Chemistry) chem containing interstitial atoms or ions: an interstitial compound. 4. (Biology) anatomy zoology occurring in the spaces between organs, tissues, etc: interstitial cells.
an induration or hardening, especially hardening of a part from inflammation and in disease of the interstitial substance. The term is used chiefly for such a hardening of the intestine in the dog, hardening of the nervous system due to hyperplasia of the connective tissue or for hardening of the blood vessels.n induration or hardening, especially hardening of a part from inflammation and in disease of the interstitial substance. The term is used chiefly for such a hardening of the intestine in the dog, hardening of the nervous system due to hyperplasia of the connective tissue or for hardening of the blood vessels.