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Underlying Medical Causes of Urine Odor. Several conditions can cause strong or unusual urine odor. The most common causes include: Dehydration. Dehydration occurs when you do not drink enough fluids. If you are dehydrated, you may notice that your urine is a dark yellow or orange color and smells like ammonia.
Potentially harmful causes of urine odor. Urine odor may be caused by infection, inflammation, or other conditions of the urinary tract (kidneys, ureters, bladder and urethra) or the reproductive organs. Urine odor can also be caused by diseases that affect the urinary tract as well as other organs and body systems. Causes of urine odor related to the urinary tract include: Cystitis (bladder inflammation or infection), which can produce a foul urine odor. Prostatitis (inflammation or infection of the prostate gland).