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Researchers say consumption of artificial sweeteners such as saccharin, sucralose and aspartame led to increased risk of glucose intolerance, a condition linked to diabetes. Sweet âN Low contains saccharin. Equal original contains aspartame. Splenda contains sucralose.
They may also help with the following: 1  Weight control. One of the most appealing aspects of artificial sweeteners is that they are non-nutritive â they have virtually no calories. 2  Diabetes. Artificial sweeteners may be a good alternative to sugar if you have diabetes.