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Glucosamine and Chondroitin Sulfate Side Effects. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea.ombined with other osteoarthritis treatments (as deemed appropriate by a physician), taking glucosamine and chondroitin sulfate dietary supplements may help some patients attain optimal levels of relief from osteoarthritis-related joint pain.
Can Glucosamine and Chondroitin Cause Side Effects? Glucosamine and chondroitin are dietary supplements used most often for treating arthritis. In general, these supplements are not likely to cause significant side effects in most people. However, some side effects have been reported. (This article covers many, but not all, of the possible side effects with glucosamine and chondroitin. Your healthcare provider can discuss a more complete list of side effects with you.)