Symptoms of Hashimoto's Thyroiditis: Introduction. The types and severity of symptoms of Hashimoto's disease vary between individuals. Many people have no symptoms at all. If Hasimoto's disease leads to hypothyroidism, symptoms of an underactive thyroid may develop. At the onset of hypothyroidism, symptoms can be vague and develop slowly. They may not include weakness, weight gain, cold sensitivity, cold hands and feet, fatigue, dry skin, brittle nails, and thinning, brittle hair.
Ligand Binding Assays (LBA) is an assay, or an analytic procedure, whose procedure or method relies on the binding of ligand molecules to receptors, antibodies or other macromolecules.on specific binding refers to the binding of a ligand to something other than its designated receptor such as various other receptors, or different types of transporters in the cell membrane. For example, various antagonists can bind to multiple types receptors.
A signaling molecule. The term ligand is used for a molecule that specifically binds to another molecule, often a larger one. Ligand binding generally causes a receptor protein to undergo a change in shape.For many receptors, this shape change directly activates the receptor, enabling it to interact with other cellular molecules.For other kinds of receptors, the immediate effect of a ligand binding is to cause the aggregation of two or more receptor molecules, which leads to further molecular events inside the cell.or many receptors, this shape change directly activates the receptor, enabling it to interact with other cellular molecules. For other kinds of receptors, the immediate effect of a ligand binding is to cause the aggregation of two or more receptor molecules, which leads to further molecular events inside the cell.