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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
The physical symptoms of PMS may or may not be present. Like PMS, the symptoms of PMDD start 7-14 days before a woman's period and go away once the period starts. Unlike PMS, PMDD can seriously affect a woman's daily activities. PMDD is diagnosed as a mental health disorder.