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Connatal Pelizaeus-Merzbacher disease is the more severe of the two types. Symptoms can begin in infancy and include problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities (contractures) that restrict movement, speech difficulties (dysarthria), ataxia, and seizures.
What is premenstrual dysphoric disorder (PMDD)? PMDD is a severe form of a common problem called premenstrual syndrome, or PMS. About 75% of women of childbearing age have some PMS problems. About 2% to 10% of women in this age group have PMDD. The symptoms of PMDD are: 1  Sadness and crying. 2  Feeling nervous or anxious. 3  Anger or irritability.  Strong cravings for certain 1  foods. Problems paying attention and concentrating. 2  Fatigue. Physical problems such as breast tenderness, headaches, joint or muscle pain and swelling or bloating.  Trouble sleeping.