After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Puppies begin teething at around 3 weeks, and by approximately 6 weeks, all of their baby teeth will have erupted. Theincisors (at the front of the mouth) and the canine teeth (the fangs) erupt first, followed by the premolars. Dogs (and cats,for that matter) do not have any baby molars.
Give puppies safe chews made for puppies. Puppies even as young as 7 weeks old want to chew. Their puppy teeth begin to erupt at 3 weeks of age, and by 6 to 8 weeks, they have all their baby teeth. At 7 weeks old, puppies are still in the litter and learning to chew with their littermates.