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Though mostly water, the cytosol is full of proteins that control cell metabolism including signal transduction pathways, glycolysis, intracellular receptors, and transcription factors. Cytoplasm is a collective term for the cytosol plus the organelles suspended within the cytosol.
2. Cytosol comprises of a lot of water, dissolved ions, large water soluble molecules, smaller minute molecules and proteins. Cytoplasm on the other hand is made of water up to 80% nucleic acids, enzymes, lipids, non-organic ions, amino acids, carbohydrates, and lightweight molecular compounds. 3.