After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Puppies begin teething at around 3 weeks, and by approximately 6 weeks, all of their baby teeth will have erupted. Theincisors (at the front of the mouth) and the canine teeth (the fangs) erupt first, followed by the premolars. Dogs (and cats,for that matter) do not have any baby molars.
Teething - Puppies 12 weeks old will have most of their 28 baby teeth and may have their first 2 to 4 adult front teeth, called the incisors. Over the next three months, your puppy will be getting in all of his adult teeth. Because they are entering an active teething stage, they will want to chew.