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Drugs most commonly used to treat essential tremor include beta-blockers (propranolol) and an epilepsy drug called Mysoline (primidone). Topamax (topiramate), another drug used to treat epilepsy and migraine, helps some people.
The two first-line treatments for essential tremor are propranolol and primidone. Propranolol is a beta blocker, and this class of medications may provide improvement by blocking spindles in the muscles. Propranolol can be administered in doses of 60 mg/day to 320 mg/day.