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Normal (i.e. healthy) red bloods cells live about 120 days in the bloodstream, after which they die and are replaced by new ones. In some unhealthy conditions, for example in â¦ sickle cell anemia, red blood cells usually die about 10 times faster (after only 10 to 20 days).aking the world better, one answer at a time. Red blood cells last an average of 120 days in the bloodstream. When red blood cells age, they are removed by macrophages in the liver and spleen.
Sickle cell disease causes red blood cells to form into a crescent shape, like a sickle. The sickle-shaped red blood cells break apart easily, causing anemia. Sickle red blood cells live only 10-20 days instead of the normal 120 days.