After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Puppies begin teething at around 3 weeks, and by approximately 6 weeks, all of their baby teeth will have erupted. Theincisors (at the front of the mouth) and the canine teeth (the fangs) erupt first, followed by the premolars. Dogs (and cats,for that matter) do not have any baby molars.
  Puppies are born without teeth, but start to grow them in 2 - 3 weeks. At 8 weeks they will have a full set of 28 teeth, but some breeds may have less or more.round 4 to 5 months of age, puppies will start to lose their baby teeth and their permanent teeth begin to grow in.