Hello Lisagarmaise, Serotonin is to blame! Excessive release of 5HT(serotonin) from intestinal mucosa cells can cause diarrhea and nausea. Metformin stimulates these intestinal cells to produce increased levels of 5HT, as soon as 10-15 minutes after taking metformin. The good news is that most symptoms dissapear after taking metformin for 2-3 weeks.
Progesterone, hormone secreted by the female reproductive system that functions mainly to regulate the condition of the inner lining (endometrium) of the uterus. Progesterone is produced by the ovaries, placenta, and adrenal glands.
The changes in the internal uterine lining of the uterus-the endometrium-during the menstrual cycle is termed the uterine cycle of menstruation. These changes occur in response to the hormones, estrogen and progesterone, secreted by the ovaries during the ovarian cycle of menstruation.The Uterine cycle of menstruation starts from the first day of the menstrual period, which is also the first day of bleeding.hese changes occur in response to the hormones, estrogen and progesterone, secreted by the ovaries during the ovarian cycle of menstruation. The Uterine cycle of menstruation starts from the first day of the menstrual period, which is also the first day of bleeding.