After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Puppies begin teething at around 3 weeks, and by approximately 6 weeks, all of their baby teeth will have erupted. Theincisors (at the front of the mouth) and the canine teeth (the fangs) erupt first, followed by the premolars. Dogs (and cats,for that matter) do not have any baby molars.
Normal puppies have 28 deciduous teeth, also known as baby teeth or milk teeth. These teeth appear at three to four weeks of age. There should be 14 teeth in the upper jaw, and 14 teeth in the lower jaw. Permanent adult teeth begin to emerge around the age of four months.