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Morphine is part of a class of drugs called opiate (narcotic) analgesics, or opioid agonists, which block the transmission of pain signals to the brain by binding to nervous system proteins called opioid receptors. Morphine is also sometimes prescribed off label to treat pain in hospitalized children. The Food and Drug Administration (FDA) first approved morphine in 1941. Multiple companies, including King Pharmaceuticals, Hospria, and Roxane Laboratories, manufacture the drug under different brand names.
If the physician orders the morphine to be given on a PRN or as needed basis, when the patient has COPD, and allows a shorter frequency of administration than that needed for the previous dosage to wear off or be metabolized, the concentration of morphine actually in the patient's blood may increase beyond a therapeutic level, causing severe adverse effects, even respiratory shutdown.