After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Puppies begin teething at around 3 weeks, and by approximately 6 weeks, all of their baby teeth will have erupted. Theincisors (at the front of the mouth) and the canine teeth (the fangs) erupt first, followed by the premolars. Dogs (and cats,for that matter) do not have any baby molars.
At around three weeks of age, puppies begin to wean. They start eating and drinking and gradually give up nursing. Weaning is a process that takes two to three weeks to complete. Puppies' milk teeth begin to grow in at about 3 weeks of age, making nursing uncomfortable for mom.