A U wave as seen on ECG. An electrocardiogram of an 18-year-old man showing U waves, most evident in lead V3. The U wave is a wave on an electrocardiogram that is not always seen. It is typically small, and, by definition, follows the T wave. U waves are thought to represent repolarization of the papillary muscles or Purkinje fibers.
HCP is caused by mutations in the CPOX gene, which codes for the enzyme coproporphyrinogen oxidase. This enzyme is responsible for the sixth step in the heme biosynthetic pathway, converting coproporphyrinogen III to protoporphyrinogen IX.
Human genetics: Pleiotropic mutations. Hannah Stower. A large-scale analysis of SNPs and genes that are reported to be associated with common complex diseases and traits has found abundant pleiotropy: that is, each individual gene mutation may have a role in multiple diseases. large-scale analysis of SNPs and genes that are reported to be associated with common complex diseases and traits has found abundant pleiotropy: that is, each individual gene mutation may have a role in multiple diseases.