Hello Lisagarmaise, Serotonin is to blame! Excessive release of 5HT(serotonin) from intestinal mucosa cells can cause diarrhea and nausea. Metformin stimulates these intestinal cells to produce increased levels of 5HT, as soon as 10-15 minutes after taking metformin. The good news is that most symptoms dissapear after taking metformin for 2-3 weeks.
Progesterone, hormone secreted by the female reproductive system that functions mainly to regulate the condition of the inner lining (endometrium) of the uterus. Progesterone is produced by the ovaries, placenta, and adrenal glands.
Many of the principal hormones of vertebrates, such as growth hormone and thyrotropin, are secreted by the pituitary gland, which is in turn regulated by neurohormone secretions of the hypothalamus. Hormones also include the endorphins, androgens, and estrogens. See more at endocrine gland.