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Normal (i.e. healthy) red bloods cells live about 120 days in the bloodstream, after which they die and are replaced by new ones. In some unhealthy conditions, for example in â¦ sickle cell anemia, red blood cells usually die about 10 times faster (after only 10 to 20 days).aking the world better, one answer at a time. Red blood cells last an average of 120 days in the bloodstream. When red blood cells age, they are removed by macrophages in the liver and spleen.
Red blood cells are produced in the bone marrow and then released into the bloodstream. Normally, they live for 110 to 120 days. Old red blood cells are removed from the blood by the spleen and liver. In people with hemolytic anemia, red blood cells have an abnormally short life span. There can be something wrong with the red blood cells. Or the red blood cells are normal but are destroyed by an external process. Many different problems can cause hemolytic anemia.