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Drugs most commonly used to treat essential tremor include beta-blockers (propranolol) and an epilepsy drug called Mysoline (primidone). Topamax (topiramate), another drug used to treat epilepsy and migraine, helps some people.
Severe essential tremor can be reduced using medication in most (approx. 50â75 percent) cases. Beta-blockers, such as propranolol (Inderal), and antiseizure medications (e.g., primidone [Mysoline], gabapentin [Neurontin]) often are prescribed.