After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Puppies begin teething at around 3 weeks, and by approximately 6 weeks, all of their baby teeth will have erupted. Theincisors (at the front of the mouth) and the canine teeth (the fangs) erupt first, followed by the premolars. Dogs (and cats,for that matter) do not have any baby molars.
All of the deciduous teeth should be in place by about eight weeks of age. These first teeth are small, and painfully sharp, as owners of young puppies know. This is part of the reason most mother dogs begin to wean their pups at five or six weeks of age. By eight to twelve weeks of age, the roots of the deciduous teeth are starting to resorb and the teeth begin to loosen and fall out.