Doctor: Brown patches and spots on skin appear for many reasons â age, sun exposure, pregnancy, as a side effect of certain medi dications, freckles, moles, hormones, rashes, and dozens more. Commonly known as hyperpigmentation, and also called a melasma or a lentigo, a brown patch or spot on the skin is harmless yet disturbing to most people because of the way it looks.
There may be an increased risk of side effects on the kidneys if meloxicam is used with any of the following medicines: 1  ACE inhibitors, eg enalapril. 2  angiotensin II receptor antagonists, eg losartan. 3  ciclosporin. diuretics, eg furosemide.  tacrolimus.
Fluid retention and edema observed in some patients treated with NSAIDs; use of meloxicam may blunt cardiovascular effects of several therapeutic agents used to treat these medical conditions (e.g., diuretics, ACE inhibitors, or angiotensin receptor blockers)