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A: Most lymph nodes are located in the head, neck, armpits and groin area, explains Mayo Clinic. There are hundreds of these nodes in the body located in other regions such as the joints, elbows and knees and around the lungs and bowels, states the American Cancer Society.
Lymph nodes are small clumps of immune cells that act as filters for the lymphatic system. The lymphatic system runs throughout the body (like the circulatory (blood) system) and carries fluid and cells. The lymph nodes in the underarm (the axillary lymph nodes) are the first place breast cancer is likely to spread.