After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Puppies begin teething at around 3 weeks, and by approximately 6 weeks, all of their baby teeth will have erupted. Theincisors (at the front of the mouth) and the canine teeth (the fangs) erupt first, followed by the premolars. Dogs (and cats,for that matter) do not have any baby molars.
When they reach 30 days of age, their deciduous or temporary (baby) teeth start to break through the gums. Puppies have a total of 28 deciduous teeth by the time they reach 45 days of age. This is a good time to give puppies plenty of chew toys. As time goes by, these teeth are replaced by permanent teeth.