After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Puppies begin teething at around 3 weeks, and by approximately 6 weeks, all of their baby teeth will have erupted. Theincisors (at the front of the mouth) and the canine teeth (the fangs) erupt first, followed by the premolars. Dogs (and cats,for that matter) do not have any baby molars.
Puppies do not get molars as baby teeth. This is simply because they don't need them as they don't need to grind food at this stage. So by the age of 6 to 8 weeks, a puppy should have a complete set of sharp, milk teeth which are comprised of 28 teeth.