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Normal (i.e. healthy) red bloods cells live about 120 days in the bloodstream, after which they die and are replaced by new ones. In some unhealthy conditions, for example in â¦ sickle cell anemia, red blood cells usually die about 10 times faster (after only 10 to 20 days).aking the world better, one answer at a time. Red blood cells last an average of 120 days in the bloodstream. When red blood cells age, they are removed by macrophages in the liver and spleen.
The life span of a red blood cell is approximately 120 days but may be removed out of circulation at any time if it is severely damaged and non-functional. Most of the red blood cells self destruct rather than being actively removed from the circulation and destroyed. The primary site where this occurs is in the spleen.