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sickle cell disease. Sickle cell anemia, a common form of sickle cell disease, is caused by a particular mutation in the HBB gene. This mutation results in the production of an abnormal version of beta-globin called hemoglobin S or HbS. In this condition, hemoglobin S replaces both beta-globin subunits in hemoglobin.
Genetic Mutation. The gene that can cause Sickle Cell Anemia is called HBB and is located in Chromosome 11. HBB helps in the creation of hemoglobin in the body. A normal adult's hemoglobin consists of two alpha chains and two beta chains; HBB codes for the beta chain and the protein it synthesizes is called beta globin.he trait that causes sickle cell anemia is recessive, which means that the disorder will only occur in a person who is homozygous recessive for the sickle cell trait. One way for this to occur is for a person to be an offspring of two parents who are heterozygous for the sickle cell trait.