After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Puppies begin teething at around 3 weeks, and by approximately 6 weeks, all of their baby teeth will have erupted. Theincisors (at the front of the mouth) and the canine teeth (the fangs) erupt first, followed by the premolars. Dogs (and cats,for that matter) do not have any baby molars.
Puppies develop their incisors around 4 to 6 weeks of age, while their canines emerge a week or two later. Premolars appear at 6 weeks of age. Permanent teeth begin erupting after about 12 weeks of age. The permanent incisors develop first, usually by the time the puppy is 3 months old. The canine teeth and premolars become visible at about 4 or 5 months of age, while the molars do not pop through the gum line until dogs are about 6 months old.