responds to these newer agents. While refractory multiple myeloma is considered to be a disease that does not. respond to a particular therapy, the new definition of relapsed and refractory multiple myeloma includes patients. who show disease progression within 60 days of discontinuing therapy.
In the years since the two atomic bombs were dropped on Japan, a number of historians have suggested that the weapons had a two-pronged objective. First, of course, was to bring the war with Japan to a speedy end and spare American lives.resident Harry S. Truman, warned by some of his advisers that any attempt to invade Japan would result in horrific American casualties, ordered that the new weapon be used to bring the war to a speedy end. On August 6, 1945, the American bomber Enola Gay dropped a five-ton bomb over the Japanese city of Hiroshima.
The decision by the United States to drop atomic bombs on Hiroshima and Nagasaki at the end of World War II remains one of the most controversial topics in Japanese history.he result were the bombings of Hiroshima on August 6th and Nagasaki on August 9th. The timing of the bombs was also determined by the rapidly changing relationship between the US and USSR. On August 8th, 3 months after V-E day, the Soviet Union declared war on Japan.