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Normal (i.e. healthy) red bloods cells live about 120 days in the bloodstream, after which they die and are replaced by new ones. In some unhealthy conditions, for example in â¦ sickle cell anemia, red blood cells usually die about 10 times faster (after only 10 to 20 days).aking the world better, one answer at a time. Red blood cells last an average of 120 days in the bloodstream. When red blood cells age, they are removed by macrophages in the liver and spleen.
What Happens. Normal red blood cells have a 120-day life span. But people born with sickle cell disease have sickle-shaped blood cells that usually live no more than 20 days.These sickled cells can get stuck in blood vessels, blocking blood flow.hat Happens. Normal red blood cells have a 120-day life span. But people born with sickle cell disease have sickle-shaped blood cells that usually live no more than 20 days.