The factors used to determine tumor grade can vary between different types of cancer. Tumor grade is not the same as the stage of a cancer. Cancer stage refers to the size and/or extent (reach) of the original (primary) tumor and whether or not cancer cells have spread in the body. Cancer stage is based on factors such as the location of the primary tumor, tumor size, regional lymph node involvement (the spread of cancer to nearby lymph nodes), and the number of tumors present.
According to an international team of scientists reporting in the Proceedings of the National Academy of Sciences, an asteroid or comet that landed in what is now the Canadian province of Quebec might have led to a significant climate change event known as Younger Dryas.
Older age is one of the most common causes of dry skin. As we age the epidermis becomes thinner and the stratum corneum can't retain as much water as it once could. Many people start getting dry skin in their 50s; by our 60s, almost everyone is experiencing some degree of dry skin. Unfortunately, it's unavoidable.