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Lithium is a medicine that is used to treat mood disorders. Get advice on how it works. Lithium is a medicine that is used to treat mood disorders: depression where mood is severely low. bipolar affective disorder (manic depression) in which mood is excessively high on some occasions and very low on others.
As a mood stabilizer, lithium is probably more effective in preventing mania than in preventing depression, but it does reduce the risk of suicide in people with bipolar disorder. In depression alone (unipolar disorder), lithium can be used to augment other antidepressants.octors may change a bipolar patient's medication from lithium to another mood-stabilizing drug, such as valproate (Depakote), if problems with the kidneys arise. An important potential consequence of long-term lithium use is the development of renal diabetes insipidus (inability to concentrate urine).