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Normal (i.e. healthy) red bloods cells live about 120 days in the bloodstream, after which they die and are replaced by new ones. In some unhealthy conditions, for example in â¦ sickle cell anemia, red blood cells usually die about 10 times faster (after only 10 to 20 days).aking the world better, one answer at a time. Red blood cells last an average of 120 days in the bloodstream. When red blood cells age, they are removed by macrophages in the liver and spleen.
Anemia â Normal red blood cells live for about 120 days. Sickle cells are fragile and only live for 10-20 days, and the body cannot make enough new cells to compensate. This leaves people with sickle cell disease chronically short on red blood cells to carry oxygen to their tissues.