0 or 1 of previous expression; also forces minimal matching when an expression might match several strings within a search string. \. Preceding one of the above, it makes it a literal instead of a special character. Preceding a special matching character, see below.
sickle cell disease. Sickle cell anemia, a common form of sickle cell disease, is caused by a particular mutation in the HBB gene. This mutation results in the production of an abnormal version of beta-globin called hemoglobin S or HbS. In this condition, hemoglobin S replaces both beta-globin subunits in hemoglobin.
These studies are now being done by GWAS in 2 patient groups, examining both baseline HbF and the HbF response to hydroxyurea. Genetic modulation of sickle cell disease: Homozygosity for a single Î²-globin gene mutation (HBB; glu6val) causes sickle cell anemia.n addition, the T-to-G mutation at the GATA motif increased the promoter activity by 2- to 3-fold. The binding motif is uniquely conserved in simian primates with a fetal pattern of Î³-globin gene expression.