After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Puppies begin teething at around 3 weeks, and by approximately 6 weeks, all of their baby teeth will have erupted. Theincisors (at the front of the mouth) and the canine teeth (the fangs) erupt first, followed by the premolars. Dogs (and cats,for that matter) do not have any baby molars.
Puppies have 28 temporary teeth (called puppy teeth or milk teeth) that start coming in at about four weeks of age. They generally fall out between 14 and 30 weeks, when they are replaced by 42 adult teeth. If you have a puppy in this age range, keep the following in mind: Puppies who are teething may eat slightly less and chew more.