A U wave as seen on ECG. An electrocardiogram of an 18-year-old man showing U waves, most evident in lead V3. The U wave is a wave on an electrocardiogram that is not always seen. It is typically small, and, by definition, follows the T wave. U waves are thought to represent repolarization of the papillary muscles or Purkinje fibers.
HCP is caused by mutations in the CPOX gene, which codes for the enzyme coproporphyrinogen oxidase. This enzyme is responsible for the sixth step in the heme biosynthetic pathway, converting coproporphyrinogen III to protoporphyrinogen IX.
Lupus and Inheritance. The exact causes of lupus are unknown, but it is expected that genetic and environmental factors both play a part. It is thought that there is some hereditary component to the disease as people who have a family history of lupus are more likely to contract the illness.upus and Inheritance. The exact causes of lupus are unknown, but it is expected that genetic and environmental factors both play a part. It is thought that there is some hereditary component to the disease as people who have a family history of lupus are more likely to contract the illness.