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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
Mucosa - Includes a columnar epithelium with large number of mucus-secreting goblet cells (villi; present in small intestine; absent in colon), lamina propria, and muscularis mucosa; the appendix is rich in mucosa-associated lymphoid tissue (MALT) Submucosa - Contains the blood vessels and Meissner nerve plexus.