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From there, blood makes its way to the Vena cava, the largest vein in the body to return to the heart. Portal hypertension describes elevated pressure within the portal system, including the portal vein and the tributary veins that drain into it.
âPortal hypertension develops when there is resistance to portal blood flow and is aggravated by increased portal collateral blood flow. The resistance most often occurs within the liver (as is the case in cirrhosis), but it can also be prehepatic (eg, portal vein thrombosis) or posthepatic (eg, Budd-Chiari syndrome).