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A histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface. histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface.
Malignant fibrous histiocytoma is a soft tissue sarcoma that usually occurs in the limbs, most commonly the legs, and may also occur in the abdomen.Learn about malignant fibrous histiocytoma and find information on how we support and care for children and teens with sarcoma before, during, and after treatment.he exact cause of malignant fibrous histiocytoma is not entirely understood, however, studies have indicated that genetics may play a role. In addition: 1  Scientists are looking into the role of an associated genetic abnormality on the short arm of chromosome 19 that may give rise to this disease.