Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
hampered. 1  transitive verb. 2  1a : to restrict the movement of by bonds or obstacles : impede pitching â¦ violently in the seaway, hampered by her heavy tow â R. S. Porteousb : to interfere with the operation of : disrupt radio communications hampered by static â Globe &amp; Mail.