Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
Definition of operator for English Language Learners. : 1  a person who uses and controls something (such as a machine, device, or business) : someone who operates something. : 2  a person whose job is to help to connect telephone calls : a person who is in charge of a telephone switchboard.