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Abstract. A nonsense mutation occurs when a sense codon, one that codes for an amino acid, is changed to one of the chainâtermination codons, UAG, UAA or UGA. A nonsense suppressor can result from a second mutation affecting the translational apparatus. This mutation enables the cell to insert an amino acid in response to the nonsense codon, resulting in a wildâtype or near wildâtype phenotype. Some suppressor mutations change the anticodon of a transfer ribonucleic acid (tRNA) such that it can pair with the nonsense codon.
Point mutations can be subdivided into three types: 1) Nonsense mutations are the ones which code for the same amino acid. 2) Missense mutations occur in the genes which code for different amino acid. 3) Silent mutations do not affect the function of the proteins and code for different or same amino acid.