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Abstract. A nonsense mutation occurs when a sense codon, one that codes for an amino acid, is changed to one of the chainâtermination codons, UAG, UAA or UGA. A nonsense suppressor can result from a second mutation affecting the translational apparatus. This mutation enables the cell to insert an amino acid in response to the nonsense codon, resulting in a wildâtype or near wildâtype phenotype. Some suppressor mutations change the anticodon of a transfer ribonucleic acid (tRNA) such that it can pair with the nonsense codon.
Nonsense mutation. Definition. noun. A form of point mutation resulting in a nonsense codon that does not code for an amino acid and leads to a protein product that is early truncated. Supplement. In nonsense mutations, the protein product from a sequence of DNA with a nonsense mutation is prematurely truncated, incomplete and often nonfunctional.Genetic disease ...upplement. In nonsense mutations, the protein product from a sequence of DNA with a nonsense mutation is prematurely truncated, incomplete and often nonfunctional. Genetic disease such as Duchenne muscular dystrophy is caused by a nonsense mutation in gene responsible for a specific protein, for example, dystrophin.