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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
MALT stands for mucosa associated lymphoid tissue. This means that the lymphoma starts in the mucosa. The mucosa is the moist tissue that lines some organs and body cavities, including the nose, mouth, lungs, and digestive tract.