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The distance between South San Francisco and Palm Springs in a straight line is 421 miles or 677.39 Kilometers. Driving Directions & Drive Times from South San Francisco to Palm Springs can be found further down the page. Driving distances, maps and journey times are currently provided by Google mapping systems.
They can rent a car and drive through the traffic themselves. I'd rather pay the extra $130.00 for them to fly into PSP than face two hours+ in each direction on hwy 10. The one way distance between Ontario airport and Palm Springs airport is 72 miles. Palm Desert is another 18 miles from Palm Springs airport. If you must drive try hwy 60 from Ontario to Beaumont where you intersect hwy 10 just west of PS. It's not two hours driving time Ontario to Palm Springs.