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A histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface. histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface.
What is mastocytosis. Mastocytosis is a group of rare disorders caused by the presence of too many mast cells, or (mastocytes), which are part of the immune system.he increased number of mast cells in the tissues in mastocytosis is due to acquired genetic mutations in a protein called c-kit. Since this disease is an abnormal increased growth of genetically abnormal blood cells, mastocytosis is classified as a myeloproliferative neoplasm (MPN).