1 Address risk factors that can lead to coronary heart disease and other heart problems. 2  These risk factors include high blood pressure, high blood cholesterol, overweight or obesity, diabetes, smoking, lack of physical activity, and depression and other emotional health concerns. 3  Adopt healthy lifestyle changes.
Primary sclerosing cholangitis is often diagnosed before symptoms appear when a routine blood test or an X-ray taken for an unrelated condition shows liver abnormalities. Early symptoms often include: 1  Fatigue. 2  Itching.
The trapped bile then builds up in the liver, where it causes inflammation and damage to liver cells. This can eventually (usually after many years) lead to scarring of the liver (cirrhosis). Primary biliary cholangitis is called: Primary - because it is not secondary to any known cause such as alcohol. Biliary - because it affects the bile ducts.