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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
The mucosa (also known as mucus membrane) is the innermost layer of tissue. Itâs a moist epithilial membrane that lines the alimentary canal lumen from mouth to the anus. The mucosa has three major functions: 1  Secrete mucus, digestive enzymes, and hormones. 2  Absorb the end products of digestion into the blood. 3  Protect against infectious disease.