Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
manage. verb. 1. be in charge of, run, handle, rule, direct, conduct, command, govern, administer, oversee, supervise, preside over, be head of, call the shots in, superintend, call the tune in Within two years, he was managing the store.. a. to take charge of; supervise: to manage a business. b. to handle the career or functioning of: to manage a performer. 3. to dominate or influence by tact, flattery, or artifice: to manage a difficult child. 4. to control in action or use: managing a boat in a storm.