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Abstract. A nonsense mutation occurs when a sense codon, one that codes for an amino acid, is changed to one of the chainâtermination codons, UAG, UAA or UGA. A nonsense suppressor can result from a second mutation affecting the translational apparatus. This mutation enables the cell to insert an amino acid in response to the nonsense codon, resulting in a wildâtype or near wildâtype phenotype. Some suppressor mutations change the anticodon of a transfer ribonucleic acid (tRNA) such that it can pair with the nonsense codon.
As a result,red blood cells spontaneously sickle in the peripheralblood if the amount of sickle hemoglobin is greaterthan 60%.â¢3.Nonsense mutation: altered DNA codes for a stop codonthat causes premature termination of protein synthesis.In p-thalassemia major, a nonsense mutation produces a stop codon that causes premature termination of DNA transcription of the P-globin chain.Consequently, there is a marked decrease in thesynthesis of hemoglobin A (a2(32), resulting in amicrocytic anemia ...