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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
Gastric mucosa. The gastric mucosa is the mucous membrane layer of the stomach which contains the glands and the gastric pits. In humans it is about 1 mm thick and its surface is smooth, soft, and velvety. It consists of epithelium, lamina propria, and the muscularis mucosae.