Holden /hold-en/ [2 sylls.] as a boys' name is pronounced HOHL-den. It is of Old English origin, and the meaning of Holden is deep valley. The hero of JD Salinger's novel The Catcher in the Rye is named Holden Caulfield.ariations. Holden is an uncommon given name for males but a very popular last name for both adults and children (#940 out of 150436, Top 1%).
Delta-9-tetrahydrocannabinol (Î´9-THC, THC) and delta-8-tetrahydrocannabinol (Î´8-THC), mimic the actions of anandamide and 2-arachidonoylglycerol, neurotransmitters produced naturally in the body. These cannabinoids produce the effects associated with cannabis by binding to the CB1 cannabinoid receptors in the brain.
Cannabidiol (CBD), a major nonpsychotropic constituent of Cannabis, has multiple pharmacological actions, including anxiolytic, antipsychotic, antiemetic and anti-inflammatory properties. However, little is known about its safety and side effect profile in animals and humans. This review describes in vivo and in vitro reports of CBD administration across a wide range of concentrations, based on reports retrieved from Web of Science, Scielo and Medline. The keywords searched were cannabinoids, cannabidiol and side effects.