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(3) renal â glutamine break down in proximal tubule (combines with H+ -> NH4+ and eliminated) CAUSES OF HYPERAMMONAEMIA. Overproduction of ammonia. Protein/ amino acid load. gastrointestinal hemorrhage. gastric bypass. multiple myeloma. allogeneic stem cell transplantation.
Ammonia is a byproduct of the metabolism of protein. Biochemical reactions in your body rapidly convert ammonia into less harmful molecules under normal conditions. Liver disease can cause ammonia levels to build up in your body. Your brain is normally protected from the low levels of ammonia in your body by the blood-brain barrier. Liver disfunction can cause ammonia levels to build up in your brain causing permanent brain damage, a condition known as hepatic encephalopathy.