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Gene mutation on the X chromosome is most common and also explains why (depending on nationality) some 7% of males, but less than 1% of females exhibit color blindness of some form. Males only have one X chromosome, whereas females have two.
The two gene model (EYCL1 and EYCL3) used here clearly does not explain more than a portion of human eye color inheritance. Two gene model: There are two genes involved in eye color. One gene has Dominant Brown or recessive blue states, the other has Dominant Green or recessive blue states.YCL2 (bey1), the central brown eye color gene, possibly located on chromosome 15. EYCL3 (bey2), the Brown/blue eye color gene located on chromosome 15. A role has also been suggested for the Melanocortin Receptor Gene (MCIR) on chromosome 16.