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(3) renal â glutamine break down in proximal tubule (combines with H+ -> NH4+ and eliminated) CAUSES OF HYPERAMMONAEMIA. Overproduction of ammonia. Protein/ amino acid load. gastrointestinal hemorrhage. gastric bypass. multiple myeloma. allogeneic stem cell transplantation.
The production of Ammonia is a result of metabolism, problems occur when this metabolic waste is not properly cleared via the Urea cycle and kidneys. Ammonia is the by product of protein/ amino acid catabolism (break down) in the digestive process, it is not a detrimental substance if the body can clear it adequately.