1 Address risk factors that can lead to coronary heart disease and other heart problems. 2  These risk factors include high blood pressure, high blood cholesterol, overweight or obesity, diabetes, smoking, lack of physical activity, and depression and other emotional health concerns. 3  Adopt healthy lifestyle changes.
Primary sclerosing cholangitis is often diagnosed before symptoms appear when a routine blood test or an X-ray taken for an unrelated condition shows liver abnormalities. Early symptoms often include: 1  Fatigue. 2  Itching.
1 Cholangitis is inflammation of the bile ducts and is most often caused by a polymicrobial bacterial infection. 2  Biliary obstruction-such as from a stone or neoplasm-serves as a major factor in its pathogenesis. 3  The condition is less common than cholecystitis, but has significantly higher mortality (40% vs 15%).