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(3) renal â glutamine break down in proximal tubule (combines with H+ -> NH4+ and eliminated) CAUSES OF HYPERAMMONAEMIA. Overproduction of ammonia. Protein/ amino acid load. gastrointestinal hemorrhage. gastric bypass. multiple myeloma. allogeneic stem cell transplantation.
An elevated blood ammonia level is typically seen in individuals having Reyeâs syndrome. Ammonia toxicity associated with Reyeâs syndrome causes confusion, seizures and drowsiness. Gastrointestinal bleeding is a cause for raised levels of ammonia in the blood. RBCs contain a high concentration of protein. Profuse bleeding, particularly in the upper part of the GI tract, increases the protein load in the intestine and the synthesis of ammonia.