Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
operator - an agent that operates some apparatus or machine; the operator of the switchboard. manipulator. causal agency, causal agent, cause - any entity that produces an effect or is responsible for events or results. company operator - an operator who works for a company. driver - the operator of a motor vehicle.