I second that âwaterâ idea. Prunes are most effective if you eat them, and then drink one cup of water â that usually gives both your body, and the prunes enough water to soften your stools. If that doesnât work, wellâ¦ I really donât know what to say.
Abstract. The most common cystic fibrosis transmembrane conductance regulator (CFTR) mutant in cystic fibrosis patients, Î´F508 CFTR, is retained in the endoplasmic reticulum (ER) and is consequently degraded by the ubiquitin-proteasome pathway known as ER-associated degradation (ERAD).
  First of all, the endoplasmic reticulum (ER) is only found in eukaryotic cells. The domain prokaryota and archea do not have an ER. The ER consists of vescicles, cistern â¦ ae and tubules found within the cell.he ER is divided into two types--Rough and Smooth ER. Rough Endoplasmic Reticulum is important in the synthesis a â¦ nd transport of proteins. The Smooth Endoplasmic Reticulum makes lipids and is involved in drug detoxification. The ER works with the Golgi apparatus and ribosomes.