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Gene mutation on the X chromosome is most common and also explains why (depending on nationality) some 7% of males, but less than 1% of females exhibit color blindness of some form. Males only have one X chromosome, whereas females have two.
The genetics of eye color are complicated, and color is determined by multiple genes. So far, as many as 15 genes have been associated with eye color inheritance. Some of the eye-color genes include OCA2 and HERC2. The earlier belief that blue eye color is a simple recessive trait has been shown to be incorrect. The genetics of eye color are so complex that almost any parent-child combination of eye colors can occur. However, OCA2 gene polymorphism, close to proximal 5â² regulatory region, explains most human eye-color variation.