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Overview of Hypothalamic and Pituitary Hormones. The pituitary gland is often portrayed as the master gland of the body. Such praise is justified in the sense that the anterior and posterior pituitary secrete a battery of hormones that collectively influence all cells and affect virtually all physiologic processes.
The most important controller of TSH secretion is thyroid-releasing hormone. Thyroid-releasing hormone is secreted by hypothalamic neurons into hypothalamic-hypophyseal portal blood, finds its receptors on thyrotrophs in the anterior pituitary and stimulates secretion of TSH. One interesting aspect of thyroid-releasing hormone is that it is only three amino acids long.