1 Address risk factors that can lead to coronary heart disease and other heart problems. 2  These risk factors include high blood pressure, high blood cholesterol, overweight or obesity, diabetes, smoking, lack of physical activity, and depression and other emotional health concerns. 3  Adopt healthy lifestyle changes.
Primary sclerosing cholangitis is often diagnosed before symptoms appear when a routine blood test or an X-ray taken for an unrelated condition shows liver abnormalities. Early symptoms often include: 1  Fatigue. 2  Itching.
Symptoms of acute cholangitis include: 1  pain in your upper abdomen that travels towards your shoulder blade. 2  a high temperature. 3  jaundice. 4  chills. 5  confusion. 6  itchy skin. 7  generally feeling unwell.