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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
The term mucosa-associated lymphoid tissue (MALT) is used to describe lymphoid tissue which is found along the mucosa. Lymphoid tissue is part of the lymphatic system which drains fluid, filters out harmful substances and helps protect the body from infection. Mucosa is the tissue that lines spaces and passages such as the stomach and intestines.