Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
Definition of operator for Students. 1  1 : a person who manages or controls something a plow operator. 2  2 : a person in charge of a telephone switchboard. 3  3 : a person who is skillful at achieving things by persuasion or deception.