DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative anesthetic. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist.
Aroldis Chapman has thrown the fastest pitch ever recorded, but he has challengers for baseball's hottest heater in 2017. Ever since Aroldis Chapman delivered a 105 mph fastball to Tony Gwynn Jr., Chapman's name has been synonymous with velocity.
The Guinness Book of World Records still acknowledges Nolan Ryan's 100.9-mph pitch in 1974 as the fastest ever recorded. Yet pitchers Joel Zumaya and Mark Wohlers have since thrown 104- and 103-mph fastballs, respectively, since Ryan's throw, but Guinness didn't certify the results from the guns used to measure them.