Gordon Lightfoot â The Wreck Of The Edmund Fitzgerald lyrics. The legend lives on from the Chippewa on down. Of the big lake they called 'Gitche Gumee'. The lake, it is said, never gives up her dead. When the skies of November turn gloomy. With a load of iron ore twenty-six thousand tons more.
Results: A total of 14 551 live births were analysed. After adjustment for confounding factors, taking huanglian during the first trimester of pregnancy was found to be associated with increased risk of congenital malformations of the nervous system (adjusted OR 8.62, 95% CI 2.54, 29.24).
Valproate and Birth Defect Risk. Valproate use during pregnancy increases the risk of major malformations, including neural tube defects. In the United States, about 1 in 1500 babies is born with a neural tube defect. The risk of neural tube defects is much higher in babies born to mothers treated with valproate during the first 12 weeks of pregnancy, with the risk increasing to 1 in 20 babies.