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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
Submucosal fat is a prominent finding in chronic ulcerative colitis and is one of the defining features of the mural stratification seen in ulcerative colitis. In comparison, Crohn disease has transmural involvement that over time leads to replacement of submucosal fat with fibrosis and loss of mural stratification.