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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
The mucosa, or mucous membrane layer, is the innermost tunic of the wall. It lines the lumen of the GI tract. The mucosa consists of epithelium, an underlying loose connective tissue layer called lamina propria, and a thin layer of smooth muscle called the muscularis mucosa.