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Abstract. A nonsense mutation occurs when a sense codon, one that codes for an amino acid, is changed to one of the chainâtermination codons, UAG, UAA or UGA. A nonsense suppressor can result from a second mutation affecting the translational apparatus. This mutation enables the cell to insert an amino acid in response to the nonsense codon, resulting in a wildâtype or near wildâtype phenotype. Some suppressor mutations change the anticodon of a transfer ribonucleic acid (tRNA) such that it can pair with the nonsense codon.
Best Answer: Missense mutations With a missense mutation, the new nucleotide alters the codon so as to produce an altered amino acid in the protein product.Nonsense mutations With a nonsense mutation, the new nucleotide changes a codon that specified an amino acid to one of the STOP codons (TAA, TAG, or TGA).Therefore, translation of the messenger RNA transcribed from this mutant gene will stop prematurely.uch mutations are said to be silent because they cause no change in their product and cannot be detected without sequencing the gene (or its mRNA). Insertions and Deletions (Indels) Extra base pairs may be added (insertions) or removed (deletions) from the DNA of a gene. The number can range from one to thousands.