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Abstract. A nonsense mutation occurs when a sense codon, one that codes for an amino acid, is changed to one of the chainâtermination codons, UAG, UAA or UGA. A nonsense suppressor can result from a second mutation affecting the translational apparatus. This mutation enables the cell to insert an amino acid in response to the nonsense codon, resulting in a wildâtype or near wildâtype phenotype. Some suppressor mutations change the anticodon of a transfer ribonucleic acid (tRNA) such that it can pair with the nonsense codon.
see suppressor mutation. silent mutation. one in which there is a base change but because of the redundancy of the genetic code the same amino acid is coded, or one in which there is an amino acid substitution in the protein which has no detectable effect on the phenotype. somatic mutation.