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1 Hormone. 2  can be either hydrophilic (polypeptide hormone) or lipophilic (steroid) biogenic amines can be either. 3  binds specific receptor on cell surface (hydrophilic hormones) or inside cell (lipophilic hormones). 4  lipophilic hormones bind carrier proteins to travel in circulation; hydrophilic hormones travel freely.efinitions. 1  Hormone. 2  can be either hydrophilic (polypeptide hormone) or lipophilic (steroid) biogenic amines can be either. 3  binds specific receptor on cell surface (hydrophilic hormones) or inside cell (lipophilic hormones).
Lipophilic Hormones with Intracellular Receptors. Many lipid-soluble hormones diffuse across the plasma membrane and interact with receptors in the cytosol or nucleus. The resulting hormone-receptor complexes bind to transcription-control regions in DNA thereby affecting expression of specific genes (see Figure 20-2a).Hormones of this type include the steroids (e.g., cortisol, progesterone, estradiol, and testosterone), thyroxine, and retinoic acid (see Figure 10-65).he resulting hormone-receptor complexes bind to transcription-control regions in DNA thereby affecting expression of specific genes (see Figure 20-2a). Hormones of this type include the steroids (e.g., cortisol, progesterone, estradiol, and testosterone), thyroxine, and retinoic acid (see Figure 10-65).