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Stay on the safe side and avoid use. Underactive thyroid (hypothyroidism): There is a concern that propionyl-L-carnitine might make hypothyroidism worse or thyroid hormone treatment less effective. This is because a related chemical, L-carnitine, seems to interfere with thyroid hormone.
How Well It Works. People with hypothyroidism who take thyroid hormone medicine usually notice: 1  Improved energy level. 2  Gradual weight loss (in people with severe hypothyroidism at the time of diagnosis). 3  Improved mood and mental function (thinking, memory).4  Improved pumping action of the heart and improved digestive tract function.ome of these medicines include: 1  Calcium. 2  Take calcium supplements at least 4 hours before or after taking thyroid hormone medicine. 3  Iron supplements. 4  Birth control pills or other hormones. 5  Cholestyramine. 6  Sucralfate and some antacids containing aluminum hydroxide.