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These infections are called âopportunisticâ because they take advantage of your weakened immune system, and they can cause devastating illnesses. OIs are signs of a declining immune system. Most life-threatening OIs occur when your. is below 200 cells/mm3. OIs are the most common cause of death for people with HIV/AIDS.
HIV: Early signs and symptoms. HIV is a virus that attacks a person's immune system. It can weaken the immune system to the point where a person's body struggles to fight infections and disease. If left untreated, HIV can lead to the disease AIDS. AIDS stands for acquired immunodeficiency syndrome. AIDS is the final stage of HIV infection.