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Radiation therapy can have side effects, and these vary from person to person. The most common side-effects are: 1  Sunburn-type skin irritation of the targeted area (which may range from mild to intense). 2  Red, dry, tender, or itchy skin. 3  Breast heaviness. 4  Discoloration, redness, or a bruised appearance.
Answers from Sandhya Pruthi, M.D. Dry skin after breast cancer radiation treatment is fairly common, especially for people who live in dry climates. In addition to dry, flaky, itchy skin, you may experience sunburn-like skin changes to the treated area.