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1 Hormone. 2  can be either hydrophilic (polypeptide hormone) or lipophilic (steroid) biogenic amines can be either. 3  binds specific receptor on cell surface (hydrophilic hormones) or inside cell (lipophilic hormones). 4  lipophilic hormones bind carrier proteins to travel in circulation; hydrophilic hormones travel freely.efinitions. 1  Hormone. 2  can be either hydrophilic (polypeptide hormone) or lipophilic (steroid) biogenic amines can be either. 3  binds specific receptor on cell surface (hydrophilic hormones) or inside cell (lipophilic hormones).
Water-soluble hormones include glycoproteins, catecholamines, and peptide hormones composed of polypeptides, e.g. thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone and insulin. These molecules are not lipid-soluble and therefore cannot diffuse through cell membranes. Consequently, receptors for peptide hormones are located on the plasma membrane. The main two types of transmembrane receptor hormone receptor are the G-protein-coupled receptors and the enzyme-linked receptors.