The impact of a moderate to severe brain injury depends on the following: 1  Severity of initial injury. 2  Rate/completeness of physiological recovery. 3  Functions affected.  Meaning of dysfunction to the 1  individual. Resources available to aid recovery.  Areas of function not affected by TBI.
In humans, administration of histrelin acetate results in an initial increase in circulating levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a transient increase in concentration of gonadal steroids (testosterone and dihydrotestosterone in males); however, continuous administration of histrelin acetate results in decreased levels of LH and FSH due to a reversible down-regulation of the GnRH receptors in the pituitary gland and desensitization ...
2 of 20 Leuprolide acetate is not active when given orally. Pharmacokinetics Absorption Following a single injection of the three month formulation of LUPRON DEPOTâ3 Month 11.25 mg in female subjects, a mean plasma leuprolide concentration of 36.3 ng/mL was observed at 4 hours.UPRON DEPOTâ3 Month 11.25 mg is indicated for management of endometriosis, including pain relief and reduction of endometriotic lesions. LUPRON DEPOT with norethindrone acetate 5 mg daily is also indicated for initial management of endometriosis and for management of recurrence of symptoms.