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Radiation therapy can have side effects, and these vary from person to person. The most common side-effects are: 1  Sunburn-type skin irritation of the targeted area (which may range from mild to intense). 2  Red, dry, tender, or itchy skin. 3  Breast heaviness. 4  Discoloration, redness, or a bruised appearance.
Side Effects of Radiation Therapy. Radiation therapy has some side effects. Some begin during treatment, while others may occur months or even years later. Most often, side effects from radiation therapy begin within a few weeks of starting treatment and go away within a few weeks after treatment ends [15]. During and just after treatment, your treated breast may be sore.