The hypodermis is the innermost and thickest layer of the skin. It invaginates into the dermis and is attached to the latter, immediately above it, by collagen and elastin fibres. It is essentially composed of a type of cells specialised in accumulating and storing fats, known as adipocytes.
Fatal familial insomnia Fatal familial insomnia (FFI) is a very rare, autosomal dominant inherited, disease of the brain. It is caused by a mutation in a protein called prion protein (PrP): asparagine-178 is replaced by aspartic acid.
What Is Fatal Familial Insomnia? When Stacey approaches her professor, Dr. Zui, about fatal familial insomnia (FFI), she notices his grim expression and figures it must be a serious condition. Characterized by a sharp incline of insomnia, FFI is a familial condition, which means it's passed on from parent to child through many generations.