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Blood tests. 1  Antibody tests. If there's a need for additional confirmation, a monospot test may be done to check your blood for antibodies to the Epstein-Barr virus. 2  White blood cell count. Your doctor may use other blood tests to look for an elevated number of white blood cells (lymphocytes) or abnormal-looking lymphocytes.
The mono test may be repeated at a later time and/or tests specific for EBV antibodies may be performed to help confirm or rule out the mononucleosis diagnosis. Most infants and young children will not make heterophile antibodies, so they will have negative mono tests even when infected with EBV.