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A stem cell transplant is used for treatment when: 1  Your body cannot make the blood cells it needs because your bone marrow or stem cells have failed. 2  Your bone marrow or blood cells have become diseased.3  In this case you need healthy stem cells to replace the diseased bone marrow/stem cells. Your body cannot make the blood cells it needs because your bone marrow or stem cells have failed. 2  Your bone marrow or blood cells have become diseased. 3  In this case you need healthy stem cells to replace the diseased bone marrow/stem cells.
The process of collecting (harvesting) stem cells for transplant depends on the source of the stem cells. Stem cells can be collected from bone marrow, circulating (peripheral) blood or umbilical cord blood. Stem cells from bone marrow. Stem cells are 10â100 times more concentrated in bone marrow than in peripheral blood. The hip (pelvic) bone contains the largest amount of active marrow in the body and large numbers of stem cells. Harvesting stem cells from the bone marrow is usually done in the operating room. The person will be given an epidural (spinal) or general anesthetic.