The impact of a moderate to severe brain injury depends on the following: 1  Severity of initial injury. 2  Rate/completeness of physiological recovery. 3  Functions affected.  Meaning of dysfunction to the 1  individual. Resources available to aid recovery.  Areas of function not affected by TBI.
In humans, administration of histrelin acetate results in an initial increase in circulating levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a transient increase in concentration of gonadal steroids (testosterone and dihydrotestosterone in males); however, continuous administration of histrelin acetate results in decreased levels of LH and FSH due to a reversible down-regulation of the GnRH receptors in the pituitary gland and desensitization ...
Am Fam Physician. 2007 Feb 15;75(4):544-546. Ranolazine (Ranexa) represents a new class of drugs known as metabolic modulators. It is labeled for use in combination with amlodipine (Norvasc), beta blockers, or nitrates in patients with chronic angina who have not had adequate antianginal responses.t generally should be used in combination with amlodipine, beta blockers, or long-acting nitrates. Because ranolazine has the potential to induce arrhythmia, it should be reserved for use in patients who have not achieved adequate responses with other antianginal therapies.