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1 Hormone. 2  can be either hydrophilic (polypeptide hormone) or lipophilic (steroid) biogenic amines can be either. 3  binds specific receptor on cell surface (hydrophilic hormones) or inside cell (lipophilic hormones). 4  lipophilic hormones bind carrier proteins to travel in circulation; hydrophilic hormones travel freely.efinitions. 1  Hormone. 2  can be either hydrophilic (polypeptide hormone) or lipophilic (steroid) biogenic amines can be either. 3  binds specific receptor on cell surface (hydrophilic hormones) or inside cell (lipophilic hormones).
As for protein hormones (peptide), they are hydropholic hormones. They will be able to diffuse through the plasma of the blood, but not through the plasma membrane of cells. They must attach to receptors on the surface of the cell and activate secondary messengers.s for protein hormones (peptide), they are hydropholic hormones. They will be able to diffuse through the plasma of the blood, but not through the plasma membrane of cells. They must attach to receptors on the surface of the cell and activate secondary messengers.