Coagulase reacts with prothrombin in the blood. The resulting complex is called staphylothrombin, which enables the enzyme protease to convert fibrinogen, a plasma protein produced by the liver, to fibrin.
Chromosome diseases are genetic diseases where a large part of the genetic code has been disrupted. Chromosomes are long sequences of DNA that contain hundreds or thousands of genes.
Mutations are permanent changes in the sequences of genomic DNA. The mutations that are of main interest to medical genetics are the ones that have deleterious effects on the phenotype and cause disease conditions. Recent advances in medical genetics led to the discovery of an increasing number of mutations that are responsible for genetic diseases.