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These infections are called âopportunisticâ because they take advantage of your weakened immune system, and they can cause devastating illnesses. OIs are signs of a declining immune system. Most life-threatening OIs occur when your. is below 200 cells/mm3. OIs are the most common cause of death for people with HIV/AIDS.
1 Acute HIV Infection. 2  Acute HIV infection is the earliest stage of HIV. 3  Acute HIV infection generally develops within 2 to 4 weeks after a person is infected with HIV. 4  During acute HIV infection, many people have flu-like symptoms, such as fever, headache, and rash.