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Guatemala City (Spanish: Ciudad de Guatemala), locally known as Guatemala or Guate, is the capital and largest city of the Republic of Guatemala, and the most populous in Central America.
â¢ GUATEMALA (noun). The noun GUATEMALA has 1 sense: 1. a republic in Central America; achieved independence from Spain in 1821; noted for low per capita income and illiteracy; politically unstable. Familiarity information: GUATEMALA used as a noun is very rare.