Alport syndrome is caused by mutations in COL4A3, COL4A4, and COL4A5, all genes involved in collagen biosynthesis. Mutations in any of these genes prevent the proper production or assembly of the type IV collagen network, which is an important structural component of basement membranes in the kidney, inner ear, and eye.Basement membranes are thin, sheet-like structures that separate and support cells in many tissues.utations in any of these genes prevent the proper production or assembly of the type IV collagen network, which is an important structural component of basement membranes in the kidney, inner ear, and eye. Basement membranes are thin, sheet-like structures that separate and support cells in many tissues.
Company vision, values, norms, systems, symbols, language, assumptions, beliefs, and habits. Also slightly unhelpful. I feel the most important distinction to make here is that company culture is something that is pre-existing in your companyâs genetic code; itâs not something that employees bring with them. In fact, a company with just one employee â a company with no employees, if weâre being honest â still has a culture.
What is safety culture? âThe safety culture of an organisation is the product of individual and group values, attitudes, perceptions, competencies, and patterns of behaviour that determine the commitment to, and the style and proficiency of, an organisationâs health and safety management. Organisations with a positive safety culture are characterised by communications founded on mutual trust, by shared perceptions of the importance of safety and by confidence in the efficacy of preventive measures.â ACSNI Human Factors Study Group: Third report - Organising for safety HSE Books 1993 Note: Safety culture is an important topic, but time consuming to inspect (because of the sample required) and difficult to tackle. It is recommended that it is only be taken on where there is good reason to believe that there is a significant issue to address, such as a poor safety record over a period, and where the company is likely to be receptive to advice. An organisationâs culture can have as big an influence on safety outcomes as the safety management system. âSafety cultureâ is a subset of the overall company culture (and is defined in the box on the right). Many companies talk about âsafety cultureâ when