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Blood tests. 1  Antibody tests. If there's a need for additional confirmation, a monospot test may be done to check your blood for antibodies to the Epstein-Barr virus. 2  White blood cell count. Your doctor may use other blood tests to look for an elevated number of white blood cells (lymphocytes) or abnormal-looking lymphocytes.
1 A monospot, which confirms that you've got mono. Blood tests that look for EBV antibodies and liver function tests can also help with a diagnosis of mono.  A CBC (complete blood count) will show if your lymphocytes, a type of white blood cell, show certain changes that may be a sign of mono.