Coagulase reacts with prothrombin in the blood. The resulting complex is called staphylothrombin, which enables the enzyme protease to convert fibrinogen, a plasma protein produced by the liver, to fibrin.
Chromosome diseases are genetic diseases where a large part of the genetic code has been disrupted. Chromosomes are long sequences of DNA that contain hundreds or thousands of genes.
It has long been known that mutations in non-coding regions which affect gene expression can cause human genetic disease. Classic examples include variants of the thalassaemias (1), hypercholesterolemia (2) and, at a slightly more complex level, Fragile X syndrome.