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Blood tests. 1  Antibody tests. If there's a need for additional confirmation, a monospot test may be done to check your blood for antibodies to the Epstein-Barr virus. 2  White blood cell count. Your doctor may use other blood tests to look for an elevated number of white blood cells (lymphocytes) or abnormal-looking lymphocytes.
EBV antibody testing is usually done when you have symptoms of infectious mononucleosis and a monospot test result is negative. EBV antibody testing may also be done to check for antibodies to EBV when a person has a disease or uses medicine that causes problems with the immune system.ononucleosis Tests. Guide. Mononucleosis tests are blood tests to look for antibodies that indicate mononucleosis (mono), which is usually caused by the Epstein-Barr virus (EBV) . The antibodies are made by the immune system to fight an infection. Mono tests include: 1  Monospot test (heterophil test).