Risk Factors for Proteinuria. Both diabetes and high blood pressure can cause damage to the kidneys, which leads to proteinuria. Other types of kidney disease unrelated to diabetes or high blood pressure can also cause protein to leak into the urine. Increased production of proteins in the body can lead to proteinuria.
Depending on the location, different glial cell types make myelin in a different manner. Schwann cells make myelin in the peripheral nervous system (PNS: nerves) and oligodendrocytes in the central nervous system (CNS: brain and spinal cord). In the PNS, one Schwann cell forms a single myelin sheath (Figure 1A).he nervous system is comprised of two primary cell types: neurons and glial cells. These cells communicate with each other to perform important tasks in the nervous system. The glial cells support neurons structurally and maintain their long-term neuronal integrity, and neurons regulate glial cell behavior.
Each oligodendrocyte can supply myelin for several axons and each axon can be supplied by several oligodendrocytes. Oligodendrocytes wrap the myelin around the axons in thin sheets like rolled up paper. Schwann cells, another kind of glial cell, makes a slightly different kind of myelin in the peripheral nervous system.When parts of the myelin sheath is lost, oligodendrocytes attempt to replace it. In acute MS lesions, typical of very aggressive disease courses, oligodendrocytes are found in large numbers and there is evidence of abortive remyelination-probably the new myelin is being destroyed faster than the oligodendrocytes can lay it down.