The hypodermis is the innermost and thickest layer of the skin. It invaginates into the dermis and is attached to the latter, immediately above it, by collagen and elastin fibres. It is essentially composed of a type of cells specialised in accumulating and storing fats, known as adipocytes.
Fatal familial insomnia Fatal familial insomnia (FFI) is a very rare, autosomal dominant inherited, disease of the brain. It is caused by a mutation in a protein called prion protein (PrP): asparagine-178 is replaced by aspartic acid.
Terminal Insomnia - When Sleep Deprivation Is Fatal. Terminal insomnia is a very rare but deadly condition. The two main kinds of terminal insomnia, fortunately, affect fewer than 100 people in the entire world. Fatal familial insomnia is a hereditary condition in which just one amino acid in one gene for one protein is wrong. It makes a protein in which 252 amino acids are right but 1 is wrong, called a prion. As the amount of the protein builds up over decades, it eventually has devastating effects on the brain.