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Blood tests. 1  Antibody tests. If there's a need for additional confirmation, a monospot test may be done to check your blood for antibodies to the Epstein-Barr virus. 2  White blood cell count. Your doctor may use other blood tests to look for an elevated number of white blood cells (lymphocytes) or abnormal-looking lymphocytes.
A series of tests can detect different types of antibodies to help determine whether you were infected recently or sometime in the past. Why It Is Done. The monospot test is done to help diagnose a recent mono infection. Epstein-Barr virus (EBV) antibody testing is also done to help diagnose mono. The EBV antibody test can help determine whether you have ever been infected with the virus and whether the infection has been recent. EBV antibody testing is usually done when you have symptoms of infectious mononucleosis and a