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These infections are called âopportunisticâ because they take advantage of your weakened immune system, and they can cause devastating illnesses. OIs are signs of a declining immune system. Most life-threatening OIs occur when your. is below 200 cells/mm3. OIs are the most common cause of death for people with HIV/AIDS.
HIV, or human immunodeficiency (HYOO-mun ih-myoo-no-dih-FIH-shen-see) virus, is a virus that can weaken the body's immune system. Infection with HIV causes a life-threatening illness called AIDS, or acquired immunodeficiency syndrome.he opportunistic infections associated with HIV disease can affect every system in the body, such as: 1  Pneumocystis carinii (nu-mo-SIS-tis kah-RIH-neeeye) pneumonia (PCP): pneumonia caused by an organism that has both parasite and fungus properties.