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Memory-like effects in brain reward pathway could contribute to drug addiction. The effects of nicotine upon brain regions involved in addiction mirror those of cocaine, according to new neuroscience research. A single 15-minute exposure to nicotine caused a long-term increase in the excitability of neurons involved in reward, according to a study published in The Journal of Neuroscience.
It's because nicotine may help people feel calmer, causing temporary feelings of relaxation as well as reducing stress, anxiety and even pain [source: World Health Organization ]. In spite of that relaxation, though, nicotine actually increases physical stress; its effects are considered a bit of a paradox. It perks up the central nervous system, but depending on the dosage some smokers find nicotine also acts as a sedative.