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These infections are called âopportunisticâ because they take advantage of your weakened immune system, and they can cause devastating illnesses. OIs are signs of a declining immune system. Most life-threatening OIs occur when your. is below 200 cells/mm3. OIs are the most common cause of death for people with HIV/AIDS.
Opportunistic infections (OIs) are infections that occur more frequently and are more severe in individuals with weakened immune systems, including people with HIV.hen a person living with HIV gets certain infections (called opportunistic infections, or OIs), he or she will get a diagnosis of AIDS, the most serious stage of HIV infection. AIDS is also diagnosed if a type of blood cell that fights infection (known as CD4 cells) falls below a certain level in persons with HIV.