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1. ADH is synthesized in the hypothalamus while aldosterone is made in the adrenal cortex. 2. ADH conserves water directly through its reabsorption while aldosterone conserves water indirectly through the reabsorption of sodium.hese processes can be carried out by these two hormones. ADH is completely known as the antidiuretic hormone. It is also identified as AVP or arginine vasopressin or simply vasopressin. Basically, the difference between the two is regarding the mechanism of action.
ADH is not the only hormone that helps with the regulation of kidney function - aldosterone (from the adrenal cortex) as well as parathyroid hormone (from the parathyroid glands) affects the balance and regulation of electrolyte content of the blood and body fluids.