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A stem cell transplant is used for treatment when: 1  Your body cannot make the blood cells it needs because your bone marrow or stem cells have failed. 2  Your bone marrow or blood cells have become diseased.3  In this case you need healthy stem cells to replace the diseased bone marrow/stem cells. Your body cannot make the blood cells it needs because your bone marrow or stem cells have failed. 2  Your bone marrow or blood cells have become diseased. 3  In this case you need healthy stem cells to replace the diseased bone marrow/stem cells.
During your stem cell transplant. After conditioning, the stem cell transplant can take place. On the day of your transplant, called day zero, you are given the stem cells through your central line using a process known as infusion. The transplant infusion is painless. You are awake during the procedure.