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A stem cell transplant is used for treatment when: 1  Your body cannot make the blood cells it needs because your bone marrow or stem cells have failed. 2  Your bone marrow or blood cells have become diseased.3  In this case you need healthy stem cells to replace the diseased bone marrow/stem cells. Your body cannot make the blood cells it needs because your bone marrow or stem cells have failed. 2  Your bone marrow or blood cells have become diseased. 3  In this case you need healthy stem cells to replace the diseased bone marrow/stem cells.
HLA matching is a key factor when it comes to stem cell transplants, whether cord blood or bone marrow transplants. Stem cell donor and HLA matching are integral to improving the success of a transplant, to promoting engraftment or the growth of new cells, and to preventing transplant rejection, also known as GVHD.t is the responsibility of a transplant center to find a stem cell donor for a patient, and not the individual. A doctor may perform a preliminary search for a donor without obliging the patient to necessarily undergo a stem cell transplant.