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Radiation therapy can have side effects, and these vary from person to person. The most common side-effects are: 1  Sunburn-type skin irritation of the targeted area (which may range from mild to intense). 2  Red, dry, tender, or itchy skin. 3  Breast heaviness. 4  Discoloration, redness, or a bruised appearance.
Radiotherapy can have side effects that occur both during and after the treatment. In the first weeks after beginning radiation therapy, you may notice reddening or swelling of the skin over the breast area and fatigue or tiredness. These problems usually disappear within 3 to 6 months. In the first 5 years after treatment, you may experience discomfort, pain, swelling, discolouration or other skin changes in the breast area. However, over 90% of women are satisfied with the appearance of the breast after lumpectomy and radiation treatment.