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Blood tests. 1  Antibody tests. If there's a need for additional confirmation, a monospot test may be done to check your blood for antibodies to the Epstein-Barr virus. 2  White blood cell count. Your doctor may use other blood tests to look for an elevated number of white blood cells (lymphocytes) or abnormal-looking lymphocytes.
1 This may lead to a false-negative result. 2  If the first test does not indicate mono but you still have symptoms, the test may be repeated. 3  Other infection or disease, such as cytomegalovirus (CMV), leukemia or lymphoma, rubella, hepatitis, or lupus.easons you may not be able to have the test or why the results may not be helpful include: 1  Having an EBV antibody test within the first few weeks of becoming infected with EBV. 2  This may lead to a false-negative result.