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Radiation therapy can have side effects, and these vary from person to person. The most common side-effects are: 1  Sunburn-type skin irritation of the targeted area (which may range from mild to intense). 2  Red, dry, tender, or itchy skin. 3  Breast heaviness. 4  Discoloration, redness, or a bruised appearance.
Side Effects of Radiation Therapy Radiation therapy has some side effects. Some begin during treatment, while others may occur months or even years later. Short-term side effects Most often, side effects from radiation therapy begin within a few weeks of starting treatment and go away within a few weeks after treatment ends [15]. During and just after treatment, your treated breast may be sore.