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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
Symptoms of Syphilis in women. In women, symptoms may be a bit more hidden because chancres can appear in the inner part of the vagina or at the opening of the cervix. Since they are not in reach and may not cause a noticeable discomfort, these sores may not trigger the attention of the infected woman.