If you have a hemoglobin variant, such as sickle cell hemoglobin (hemoglobin S), you will have a decreased amount of hemoglobin A. This may limit the usefulness of the A1c test in monitoring your diabetes. If you have anemia, hemolysis, or heavy bleeding, your test results may be falsely low.
Who was the president that believed that a US-controlled canal across Central America was a vital strategic interest to America and so was largely responsible for construction of the Panama Canal? Theodore Roosevelt
A History of the Panama Canal: French and American Construction Efforts. This history prepared by the Panama Canal Commission looks only at the construction of the Panama Canal, beginning with the first known idea for a trans-American canal in 1513 and ending with its completion 401 years later. The article on the design and operation of the locks is especially interesting.