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Quick Answer. High PSA levels may indicate prostate cancer, prostatitis or an enlarged prostate, states WebMD. PSA levels in men naturally increase with age. In most cases, a PSA level under 4 nanograms per milliliter is considered normal, and men with this result have a low chance of prostate cancer. Continue Reading.
The chance of having prostate cancer goes up as the PSA level goes up. If your level is between 4 and 10, you have about a 1 in 4 chance of having prostate cancer. If it is above 10, your chance is over 50%. But some men with a PSA below 4 can also have prostate cancer. Factors other than cancer can also cause the PSA level to go up, including: 1  An enlarged prostate like BPH (benign prostatic hyperplasia--not cancer), that many men get as they grow older.