Much scholarly and judicial attention has been dedicated to deciphering the Privileges or Immunities Clause of the Fourteenth Amendment, which states: âNo State shall make or enforce any law which shall abridge the privileges or immunities of citizens of the United States.â.
In the process of intramembranous ossification the formation of bone within CT, WHAT cells first aggregate in the vicinity of blood vessels and differentiate into osteoblast cells, which begin to synthesize and secrete the components of the matrix.
In response to infection or injury, as is seen with SIRS, HMGB1 is secreted by innate immune cells and/or released passively by damaged cells. Thus, elevated serum and tissue levels of HMGB1 would result from many of the causes of SIRS.