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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
Symptoms of primary syphilis are not as common as on its other stages of development: 1  patient has more than 1 ulcer; 2  ulcer may be followed by pain; 3  ulcer can be found in patientâs mouth after oral sex or in the rectum;