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Itâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.tâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.
Hepatitis A and B â The vaccine requires two doses, 30 days apart, which will provide you with one year of protection. You can then have a booster vaccination 6 to 12 months later which will give you 20 or more years of protection.