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An Underappreciated Risk of an Aspirin a Day. By Neena Abraham, M.D. If your physician has suggested you take aspirin to reduce your risk of heart disease, it is important to remember that even small doses of daily aspirin â including âbaby aspirin,â at a dose of 81 milligrams daily â can increase your risk of ulcers and bleeding.
Aspirin is 170 times more active against COX-1 than COX-2. That's why tiny doses can protect the heart and why they can also increase the risk of bleeding. Most experts now recommend 81 mg (a baby aspirin) a day for prevention. Much higher doses are needed to inhibit COX-2 and treat pain and fever.spirin is 170 times more active against COX-1 than COX-2. That's why tiny doses can protect the heart and why they can also increase the risk of bleeding. Most experts now recommend 81 mg (a baby aspirin) a day for prevention. Much higher doses are needed to inhibit COX-2 and treat pain and fever.