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Quick Answer. High PSA levels may indicate prostate cancer, prostatitis or an enlarged prostate, states WebMD. PSA levels in men naturally increase with age. In most cases, a PSA level under 4 nanograms per milliliter is considered normal, and men with this result have a low chance of prostate cancer. Continue Reading.
It is believed that elevation of PSA in the blood is due to its liberation into the circulation because of disruption of the prostate cellular architecture (structure). This can occur in the setting of different prostate diseases including prostate cancer. It is important to note that PSA is not specific to prostate cancer but to prostatic tissue and therefore PSA elevations may indicate the presence of any kind of prostate disease.