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However, sadness, depression, grief, or anxiety are a common cause of weight loss that is not explained by other factors, especially among the elderly. Cancer may also cause decreased appetite. You may lose weight without trying. Cancers that may cause you to lose your appetite include: 1  Colon cancer. 2  Ovarian cancer. 3  Stomach cancer. 4  Pancreatic cancer.
This may also help you keep your strength up, which can help you finish your full course of treatment. One cause is the cancer itself. For example, in an effort to fight the cancer, the body produces substances called cytokines. These substances can lead to weight loss, muscle loss, and a decrease in appetite. Another common cause is the treatments for cancer. Radiation and chemotherapy often cause a decrease in appetite.