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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
As long as the beta cells are able to produce enough insulin to overcome the insulin resistance, blood glucose levels stay in the healthy range. Over time, insulin resistance can lead to type 2 diabetes and prediabetes because the beta cells fail to keep up with the body's increased need for insulin. Without enough insulin, excess glucose builds up in the bloodstream, leading to diabetes, prediabetes, and other serious health disorders.