Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well.Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.stradiol, or more precisely, 17Î²-estradiol, is a steroid and estrogen sex hormone, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles.
The first computer retail store ordered fifty Apple I computers: this was their first sale. Jobs and Wozniak started working out of Jobs' parents house in Cupertino, California. In their first year as Apple Computer, they moved from the garage to a room in Cupertino.
(Woz for Hewlett-Packard, Jobs for Atari) Wozniak had been dabbling in computer-design for some time when, in 1976, he designed what would become the Apple I. Jobs, who had an eye for the future, insisted that he and Wozniak try to sell the machine, and on April 1, 1976, Apple Computer was born. Hobbyists did not take the Apple I very seriously, and Apple did not begin to take off until 1977, when the Apple II debuted at a local computer trade show. The first personal computer to come in a plastic case and include color graphics, the Apple II was an impressive machine.