A Brief Explanation of an Over-the-Counter Market | Definition. A over-the-counter market (OTC) refers to a decentralized and informal way of exchanging stocks, derivatives, or other assets between two parties.
The leading strand is built by using the lagging strand of the old molecule as the template. Replication of the leading strand begins with the enzyme âprimaseâ. Primase adds a small complementary piece of RNA (~10 nucleotides), called an âRNA primerâ, near the end of the lagging strand. The RNA primer gives an enzyme called âDNA polymerase IIIâ something to attach a DNA nucleotide to. A jury-rigged design, RNA primers are necessary because DNA polymerase III can only attach nucleotides to the 3â end of a pre-existing nucleotide.
An enzyme called DNA gyrase makes a nick in the double helix and each side separates; An enzyme called helicase unwinds the double-stranded DNA; Several small proteins called single strand binding proteins (SSB) temporarily bind to each side and keep them separated An enzyme complex called DNA polymerase walks down the DNA strands and adds new nucleotides to each strand.