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Dependency, or addiction, is the most common of long-term heroin effects. Heroin is often considered the most addictive of all legal and illegal substances that are commonly abused for their mind-altering effects.
The long-term effects of heroin use on health can include: 1  dependence. 2  constipation. 3  menstrual irregularity and infertility in women. 4  loss of sex drive in men. 5  intense sadness. 6  cognitive impairment. 7  tetanus. 8  damage to heart, lungs, liver and brain.ow heroin affects a person depends on many things including their size, weight and health, also whether the person is used to taking it and whether other drugs are taken around the same time. The effects of any drug also depend on the amount taken.