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Itâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.tâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.
Booster doses of vaccine do not seem necessary to ensure long-term protection, write Alessandro Zanetti, PhD, and colleagues in The Lancet. The CDC doesn't routinely recommend hepatitis B vaccine boosters for people with healthy immune systems.