Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
That said, the key difference between rheumatoid arthritis and osteoarthritis is the cause behind how the joints are affected. Osteoarthritis is a slow and progressive degenerative joint disease, that is, it will slowly develop over years of wear-and-tear on the joints and cartilage.
Although they have similar names and some common symptoms, rheumatoid arthritis (RA) and osteoarthritis (OA) have very different causes, paths of progression and treatments. Thatâs why itâs so important to see a rheumatologist for an accurate diagnosis. Below are the basic differences between RA and OA.