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How It Works. Leflunomide (Arava) is a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis. It interferes with the progression of the disease by blocking the production of white blood cells that cause the joint inflammation in rheumatoid arthritis.
Side effects: Effective birth control is essential while taking leflunomide. This drug may cause birth defects if it is taken by the mother during pregnancy or by the father during the time of conception. Individuals with kidney or liver disease may need lower doses.