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Quick Answer. High PSA levels may indicate prostate cancer, prostatitis or an enlarged prostate, states WebMD. PSA levels in men naturally increase with age. In most cases, a PSA level under 4 nanograms per milliliter is considered normal, and men with this result have a low chance of prostate cancer. Continue Reading.
Those with a PSA level between four and 10 have a 25% chance of having prostate cancer and if the PSA is higher than 10, the risk increases to 67%. Just as significant as the PSA level is the trend in that number (whether it is going up, how quickly and over what period of time).