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Itâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.tâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.
The hepatitis vaccination used most often consists of three intramuscular injections. For optimal development of protective antibodies, the second dose should be administered 1 month after the first dose and the third dose should be administered 6 months after the first dose and at least 8 weeks from the second dose.