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Drug-induced hypothyroidism may be caused by: 1  Drugs used for hyperthyroidism (overactive thyroid), such as propylthiouracil (PTU), radioactive iodine, potassium iodide, and methimazole. 2  Treatment with lithium or iodides in certain people.
Patients with nephrotic syndrome may lose thyroid hormone in their urine and require higher doses of levothyroxine. And several drugs increase the metabolism of levothyroxine and patients starting these medications may require a higher dose: dilantin, carbamezine (Tegretol), phenobarbitol, and rifampin.