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Quick Answer. High PSA levels may indicate prostate cancer, prostatitis or an enlarged prostate, states WebMD. PSA levels in men naturally increase with age. In most cases, a PSA level under 4 nanograms per milliliter is considered normal, and men with this result have a low chance of prostate cancer. Continue Reading.
If you get a high reading on your PSA test, it is recommended you have a second test four to six weeks later to verify the original results, as a manâs PSA levels can fluctuate. Read more: 15 Things That Can Increase PSA Levels.