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However, sadness, depression, grief, or anxiety are a common cause of weight loss that is not explained by other factors, especially among the elderly. Cancer may also cause decreased appetite. You may lose weight without trying. Cancers that may cause you to lose your appetite include: 1  Colon cancer. 2  Ovarian cancer. 3  Stomach cancer. 4  Pancreatic cancer.
The first is leptin, which is a hormone secreted by your fat cells that acts as an appetite suppressant. Leptin levels peak when you fill up on food. So, when you eat a lot, your appetite goes away. If you ever said, 'I am so full I couldn't eat another bite,' then in that moment, your body was flooded with leptin.