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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
Syphilis affects the body in stages. Stage 1: Primary stage. Sores appear in the genital (penis or vagina) area or the mouth within 10 days to 3 months after infection. The sores are usually firm, round, small, and painless. The sores should go away on their own, but bacteria stays in the body (without treatment).