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However, sadness, depression, grief, or anxiety are a common cause of weight loss that is not explained by other factors, especially among the elderly. Cancer may also cause decreased appetite. You may lose weight without trying. Cancers that may cause you to lose your appetite include: 1  Colon cancer. 2  Ovarian cancer. 3  Stomach cancer. 4  Pancreatic cancer.
Kidney, liver and heart disease can also reduce the appetite. In some cases, sudden loss of appetite occurs at an advanced stage illness, such as congestive heart failure or kidney failure. Psychological diseases including depression, anxiety disorder and schizophrenia can also cause sudden loss of appetite, particularly if symptoms of the underlying disease increase suddenly.