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Short-Term Effects of Heroin. Often injected, the immediate effects of heroin are to modulate pain perception. As a street drug, dosing is impossible to fully control, and the side effects of decreased heart rate and breathing pose immense risk to users.
Long-Term Effects of Painkillers. There are a number of unpleasant side effects associated with painkiller abuse. Mild side effects include nausea, vomiting, and diarrhea, usually caused by the way the drug interacts with opioid receptors along the digestive tract.he long-term effects also depend on how the drug is taken. Crushing and injecting the tablet into the bloodstream can cause long-term heart damage and other cardiovascular issues, and can increase the likelihood of a heart attack.