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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
The causes of insulin resistance include both genetic (inherited) and lifestyle factors. There are no specific signs and symptoms of insulin resistance. Insulin resistance is associated with other medical conditions, including fatty liver, arteriosclerosis, acanthosis nigerians, skin tags, and. reproductive abnormalities in women.