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Drug-induced hypothyroidism may be caused by: 1  Drugs used for hyperthyroidism (overactive thyroid), such as propylthiouracil (PTU), radioactive iodine, potassium iodide, and methimazole. 2  Treatment with lithium or iodides in certain people.
In the study, researchers found that the primary risk factors for continuing subclinical hypothyroidism included: 1  TSH above 6. 2  High levels of antithyroid antibody (thyroid peroxidase antibody or thyroglobulin antibody) 3  A shift in iodine intake from mildly deficient to more than adequate.