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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
In secondary syphilis, the infection has spread throughout the body, so other symptoms may be associated with the skin manifestations. Fever, enlarged lymph nodes, fatigue, weight loss, hair loss, headaches, and muscle aches have all been reported in the secondary stage of syphilis.econdary syphilis. If primary syphilis is left untreated, secondary syphilis may develop. This stage of the illness usually occurs weeks to months after the primary stage. Secondary syphilis is characterized by a skin rash that typically does not itch and may easily be mistaken for rashes caused by other illnesses.