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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
Tertiary syphilis can cause damage to the brain, nerves, eyes, heart, blood vessels, liver, bones, and joints. Symptoms that can result from the late stage of syphilis include problems with movement, gradual loss of sight, dementia, paralysis, and numbness. Neurosyphilis is the term used to refer to the involvement of the central nervous system and alterations in neurologic function.