Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
Arthritis is a general term for conditions that affect the joints and surrounding tissues. Joints are places in the body where bones come together, such as the knees, wrists, fingers, toes, and hips. Two common types of arthritis are osteoarthritis and rheumatoid arthritis.
Osteoarthritis is a form of arthritis that features the breakdown and eventual loss of the cartilage of one or more joints. Cartilage is a protein substance that serves as a cushion between the bones of the joints. Among the over 100 different types of arthritis conditions, osteoarthritis is the most common. Osteoarthritis is a joint inflammation that results from cartilage degeneration. 2  Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease. 3  The most common symptom of osteoarthritis is pain in the affected joint(s) after repetitive use. 4  There is no blood test for the diagnosis of osteoarthritis.