Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
That said, the key difference between rheumatoid arthritis and osteoarthritis is the cause behind how the joints are affected. Osteoarthritis is a slow and progressive degenerative joint disease, that is, it will slowly develop over years of wear-and-tear on the joints and cartilage.
Osteoarthritis is a form of arthritis that features the breakdown and eventual loss of the cartilage of one or more joints. Cartilage is a protein substance that serves as a cushion between the bones of the joints. Among the over 100 different types of arthritis conditions, osteoarthritis is the most common. Osteoarthritis is a joint inflammation that results from cartilage degeneration. 2  Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease. 3  The most common symptom of osteoarthritis is pain in the affected joint(s) after repetitive use. 4  There is no blood test for the diagnosis of osteoarthritis.