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Itâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.tâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.
A hepatitis B vaccine booster dose 30 years after vaccination is not necessary, according to results of a study published online January 21 in the Journal of Infectious Diseases. Universal vaccination with hepatitis B vaccine has been very effective on a global scale, but protection has only been assessed for 22 years.