Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
That said, the key difference between rheumatoid arthritis and osteoarthritis is the cause behind how the joints are affected. Osteoarthritis is a slow and progressive degenerative joint disease, that is, it will slowly develop over years of wear-and-tear on the joints and cartilage.
Osteoarthritis is the result of wear and tear on your joints, which causes weakening and deterioration of your cartilage [ Mayo Clinic ]. Rheumatoid arthritis, on the other hand, is an auto-immune disorder, whereby your body attacks and destroys joint cartilage [ NIAMS ].Both conditions, however, share common symptoms, including joint paint, stiffness and swelling. The risk factors for osteoarthritis and rheumatoid arthritis are fairly different.heumatoid arthritis also causes other symptoms that are unrelated to joint deterioration, such as fatigue, fever and a vague feeling of sickness. The symptoms of osteoarthritis get progressively worse as you age [ Mayo Clinic ]. The symptoms of rheumatoid arthritis, however, can flare up and dissipate.