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Quick Answer. High PSA levels may indicate prostate cancer, prostatitis or an enlarged prostate, states WebMD. PSA levels in men naturally increase with age. In most cases, a PSA level under 4 nanograms per milliliter is considered normal, and men with this result have a low chance of prostate cancer. Continue Reading.
In order to increase the efficacy of serum PSA interpretation, a number of performance variables are used clinically. These include age-adjusted PSA, density, velocity, and the free-to-complexed PSA ratio. Age Adjusted PSA: Since PSA normally rises with age, age-adjusted thresholds have been described. Benign growth of the prostate that normally occurs with age is the most common cause of PSA elevation. Roughly 70% of patients with an elevated PSA level between 4 and 10 will have a negative prostate biopsy. Conversely, there is no level of PSA at which you can guarantee a patient that they do not have cancer. Moreover, the absolute PSA level does not predict whether or not prostate cancer is harmful.