Several reports demonstrate unexplained consequences of mutations on the expression of the different dystrophin isoforms and their balance. The most prominent example is found in some cases of X-linked dilated cardiomyopathy (XLDC).
In particular, calcitonin has the ability to decrease blood calcium levels at least in part by effects on two well-studied target organs: 1  Bone: Calcitonin suppresses resorption of bone by inhibiting the activity of osteoclasts, a cell type that digests bone matrix, releasing calcium and phosphorus into blood.
Calcitonin reduces calcium levels in the blood by two main mechanisms: 1  It inhibits the activity of osteoclasts, which are the cells responsible for breaking down bone. 2  It can also decrease the resorption of calcium in the kidneys, again leading to lower blood calcium levels.