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How It Works. Leflunomide (Arava) is a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis. It interferes with the progression of the disease by blocking the production of white blood cells that cause the joint inflammation in rheumatoid arthritis.
This drug may rarely cause serious (possibly fatal) liver disease. Most cases occur within 6 months of taking this drug. If you already have liver disease (such as hepatitis B or C), leflunomide should not be used. Liver function tests must be performed periodically while taking