Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
That said, the key difference between rheumatoid arthritis and osteoarthritis is the cause behind how the joints are affected. Osteoarthritis is a slow and progressive degenerative joint disease, that is, it will slowly develop over years of wear-and-tear on the joints and cartilage.
This is not the case for osteoarthritis. In both osteoarthritis and rheumatoid arthritis, joints will be stiff and painful in the morning. For osteoarthritis, this will last around 20 minutes, but for rheumatoid arthritis, it can last more than 45 minutes. It is worth noting that it is possible to have both osteoarthritis and rheumatoid arthritis.