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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
Other symptoms of secondary syphilis include sores in the mouth, nose, and throat, and on the genitals or folds of the skin. Lymph node swelling is common, and patchy hair loss can occur. All signs and symptoms of the second stage of syphilis will disappear without treatment between three weeks and nine months, but the infection will still be present in the body.