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Drug-induced hypothyroidism may be caused by: 1  Drugs used for hyperthyroidism (overactive thyroid), such as propylthiouracil (PTU), radioactive iodine, potassium iodide, and methimazole. 2  Treatment with lithium or iodides in certain people.
Hypothyroidism occurs when the thyroid gland does not produce enough thyroid hormone. Symptoms include weight gain, fatigue, constipation, depression, puffy hands, face, and feet, skin thickening, and hair thinning. Treatment for hypothyroidism includes taking medication. Common drug classes used to treat hypothyroidism are thyroxines, triiodothyronines, and thyroxine / triiodothyronine combinations.