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However, sadness, depression, grief, or anxiety are a common cause of weight loss that is not explained by other factors, especially among the elderly. Cancer may also cause decreased appetite. You may lose weight without trying. Cancers that may cause you to lose your appetite include: 1  Colon cancer. 2  Ovarian cancer. 3  Stomach cancer. 4  Pancreatic cancer.
Lack of appetite is common during cancer treatment. Some treatments can even make food taste unpleasant. Even though you don't feel like eating, it's important to get adequate nutrition, says Sarah Rafat, RD, a senior dietitian at MD Anderson Cancer Center.