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Skin, mouth, genital symptoms â One characteristic feature of acute HIV infection is open sores or ulcers. These sores or ulcers can develop in the mouth, the esophagus (the tube that extends from the mouth to the stomach), the anus, or the penis. The ulcers are usually painful.
What are the symptoms of mouth ulcers? You may have a mouth ulcer if you have: 1  A painful sore or sores inside your mouth, on the tongue, soft palate (the back portion of the roof of your mouth), or inside your cheeks.  Sores in your mouth that are round, white, or grey in colour, with a red edge or border.