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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
Learn to identify the symptoms of latent and tertiary stage syphilis. The latent stage begins when the symptoms of stages 1 and 2 disappear. The syphilis bacteria is still in the body, but there are no longer any signs or symptoms of the disease. This stage can last for years. However, about a third of those who go untreated during the latent stage will develop the tertiary stage of syphilis, which has severe symptoms. Tertiary stage syphilis may not show itself until 10 to 40 years after the initial infection.