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Quick Answer. High PSA levels may indicate prostate cancer, prostatitis or an enlarged prostate, states WebMD. PSA levels in men naturally increase with age. In most cases, a PSA level under 4 nanograms per milliliter is considered normal, and men with this result have a low chance of prostate cancer. Continue Reading.
Prostate tissue normally releases small amounts of PSA into your blood. 1  When the prostate grows, PSA levels increase. When the entire prostate is removed, PSA levels fall close to zero. Most procedures used to treat an enlarged prostate remove only part of the prostate, which partially decreases PSA levels. After any enlarged prostate procedure, a number of factors can cause PSA levels to go up again.