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Causes of Heart Disease. Heart disease occurs when the arteries and blood vessels that lead to the heart are blocked or not carrying blood correctly. When this happens, important nutrients, such as oxygen, cannot reach your heart.ou may not show symptoms of the disease at certain times. Heart disease is sometimes called âcoronary heart diseaseâ or âCHD.â It is the leading cause of death among adults in the United States, according to the National Heart, Lung, and Blood Institute (NHLBI).
Causes of heart disease. Coronary heart disease (CHD) is usually caused by a build-up of fatty deposits on the walls of the arteries around the heart (coronary arteries).The fatty deposits, called atheroma, are made up of cholesterol and other waste substances.holesterol. Cholesterol is a fat made by the liver from the saturated fat in your diet. Cholesterol is essential for healthy cells, but too much in the blood can lead to CHD. Cholesterol is carried in the bloodstream by molecules called lipoproteins.