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Drug-induced hypothyroidism may be caused by: 1  Drugs used for hyperthyroidism (overactive thyroid), such as propylthiouracil (PTU), radioactive iodine, potassium iodide, and methimazole. 2  Treatment with lithium or iodides in certain people.
People with hypothyroidism who take thyroid hormone medicine usually notice: 1  Improved energy level. 2  Gradual weight loss (in people with severe hypothyroidism at the time of diagnosis). 3  Improved mood and mental function (thinking, memory).4  Improved pumping action of the heart and improved digestive tract function.eople with hypothyroidism who take thyroid hormone medicine usually notice: 1  Improved energy level. 2  Gradual weight loss (in people with severe hypothyroidism at the time of diagnosis). 3  Improved mood and mental function (thinking, memory). 4  Improved pumping action of the heart and improved digestive tract function.