Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
That said, the key difference between rheumatoid arthritis and osteoarthritis is the cause behind how the joints are affected. Osteoarthritis is a slow and progressive degenerative joint disease, that is, it will slowly develop over years of wear-and-tear on the joints and cartilage.
The most common type of arthritis, osteoarthritis involves wear-and-tear damage to the cartilage that caps the bones in your joints. Rheumatoid arthritis occurs when your immune system mistakenly attacks the lining of your joints, causing a painful swelling that can eventually result in joint deformity.While both rheumatoid arthritis and osteoarthritis can affect the small joints of the hand, there are differences.Rheumatoid arthritis tends to affect the middle joints of the fingers and the joints where the fingers attach to the hand.Osteoarthritis more commonly affects the joints at the ends of the fingers and at the base of the thumb. In rheumatoid arthritis, the same joints usually are affected on both sides of the body.heumatoid arthritis tends to affect the middle joints of the fingers and the joints where the fingers attach to the hand. Osteoarthritis more commonly affects the joints at the ends of the fingers and at the base of the thumb. In rheumatoid arthritis, the same joints usually are affected on both sides of the body.