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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
1 Insulin resistance is a condition in which the cells of the body become resistant to the hormone insulin. 2  Insulin resistance may be part of the metabolic syndrome, and it has been associated with higher risk of developing heart disease.  Insulin resistance precedes the development of type 2 diabetes (T2D).