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Causes of Heart Disease. Heart disease occurs when the arteries and blood vessels that lead to the heart are blocked or not carrying blood correctly. When this happens, important nutrients, such as oxygen, cannot reach your heart.ou may not show symptoms of the disease at certain times. Heart disease is sometimes called âcoronary heart diseaseâ or âCHD.â It is the leading cause of death among adults in the United States, according to the National Heart, Lung, and Blood Institute (NHLBI).
Atherosclerosis-or hardening of the arteries-is the main cause of heart disease. It occurs because of calcium build-up in the blood vessels-resulting in hard and narrow arteries.This then leads to problems such as blood flow obstruction and heart issues.therosclerosis-or hardening of the arteries-is the main cause of heart disease. It occurs because of calcium build-up in the blood vessels-resulting in hard and narrow arteries.