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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
Nonpolar and small polar molecules can pass through the cell membrane, so they diffuse across it in response to concentration gradients. Carbon dioxide and oxygen are two molecules that undergo this simple diffusion through the membrane. The simple diffusion of water is known as osmosis.mall and nonpolar (hydrophobic) molecules can freely pass through the membrane, but charged ions and large molecules such as proteins and sugars are barred passage. The selective permeability of the cell membrane allows a cell to maintain its internal composition at necessary levels.