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Itâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.tâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.
Medical Definition of Booster shot. Booster shot: An additional dose of a vaccine needed periodically to 'boost' the immune system. For example, a booster shot of the tetanus and diphtheria (Td) vaccine is recommended for adults every 10 years. Search MedTerms: