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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
The permeability of the plasma membrane. Keypoints 1  : The plasma membrane acts as a partially permeable membrane and selectively controls the movement of substances in and out of a cell. 2  Factors that determine whether a molecule can pass through the plasma membrane are the size and polarity of the molecule.