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However, sadness, depression, grief, or anxiety are a common cause of weight loss that is not explained by other factors, especially among the elderly. Cancer may also cause decreased appetite. You may lose weight without trying. Cancers that may cause you to lose your appetite include: 1  Colon cancer. 2  Ovarian cancer. 3  Stomach cancer. 4  Pancreatic cancer.
Loss of appetite can be caused by the cancer itself, especially advanced cancer. Cancer treatments may cause symptoms that may lead to loss of appetite. These treatments include chemotherapy, radiation therapy and surgery. These symptoms include: nausea and vomiting.