Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well.Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.stradiol, or more precisely, 17Î²-estradiol, is a steroid and estrogen sex hormone, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles.
The first computer retail store ordered fifty Apple I computers: this was their first sale. Jobs and Wozniak started working out of Jobs' parents house in Cupertino, California. In their first year as Apple Computer, they moved from the garage to a room in Cupertino.
Wozniak and Jobs sold their first computers in 1976.the first apple computer (the Apple I) was introduced on April 1, 1976 and its latest computer, the Macbook Air was introd â¦ uced in 2008.The Apple Computer was founded in Los Altos, California on April 1, 1976 by Steve Jobs, Steve Wozniak.They sold the Apple I personal computer kit at $666.66. They were built by hand in Jobs' parents' garage, and the Apple I was first shown to the public at the Homebrew Computer Club.ozniak and Jobs sold their first computers in 1976.the first apple computer (the Apple I) was introduced on April 1, 1976 and its latest computer, the Macbook Air was introd â¦ uced in 2008.