Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
That said, the key difference between rheumatoid arthritis and osteoarthritis is the cause behind how the joints are affected. Osteoarthritis is a slow and progressive degenerative joint disease, that is, it will slowly develop over years of wear-and-tear on the joints and cartilage.
Although both arthritic conditions cause pain and stiffness in the joints, there are important differences between osteoarthritis and rheumatoid arthritis symptoms. For example, the joints in rheumatoid arthritis will be swollen, but in osteoarthritis there is usually little to no swelling.