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What Can I Do if my HDL Cholesterol Level Is Low? If your HDL is low, you can take several steps to boost your HDL level and reduce your heart disease risk: Exercise. Aerobic exercise for 30 to 60 minutes on most days of the week can help pump up HDL. Quit smoking. Tobacco smoke lowers HDL, and quitting can increase HDL levels. Keep a healthy weight.
However, other medications, such as high-dose niacin and fibrates, can raise HDL levels significantly. High-dose niacin (Niaspan, Niacor) is usually considered the most effective medication for increasing HDL levels, although it's exact method of action is not clear.