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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
In tertiary syphilis, the disease damages your internal organs and can result in death. Neurosyphilis and Ocular Syphilis. Without treatment, syphilis can spread to the brain and nervous system (neurosyphilis) or to the eye (ocular syphilis). This can happen during any of the stages described above. Symptoms of neurosyphilis include. severe headache; difficulty coordinating muscle movements; paralysis (not able to move certain parts of your body); numbness; and. dementia (mental disorder).