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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
The signs and symptoms of syphilis are similar in both men and women and the disease progresses through 4 stages: primary, secondary, latent and tertiary. At the primary stage, bacteria enter the body and multiply at the site of infection.