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Tobramycin, the active ingredient used in the medication possesses active antibiotic properties, which when administered restricts bacterial growth by delaying the protein synthesis. Though the drug is not approved for use in animals, most veterinarians have agreed to use the medication on dogs. However, tobramycin is a prescription drug and is available in various ophthalmic preparations as injectable solution, suspension as well as ointment.
1 While generally safe and effective when prescribed by a veterinarian, tobramycin can cause side effects in some animals. 2  Tobramycin should not be used in animals with known hypersensitivity or allergy to the drug.3  The most serious adverse effect from tobramycin and others in this class of drugs is damage to the kidneys. Tobramycin and other aminoglycosides can cause loss of hearing (ototoxicity) in animals or loss of balance (vestibulotoxicity). 2  High doses can cause muscle paralysis in animals.