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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
What Are the Symptoms of Secondary Syphilis? Primary syphilis usually presents itself as a single sore. This sore typically appears three weeks after the initial infection, but could show as soon as 10 days or as late as 90 days. This sore, called a chancre, is small, firm, round, and painless.