Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
That said, the key difference between rheumatoid arthritis and osteoarthritis is the cause behind how the joints are affected. Osteoarthritis is a slow and progressive degenerative joint disease, that is, it will slowly develop over years of wear-and-tear on the joints and cartilage.
Osteoarthritis is the most common form of arthritis to affect the knees and usually occurs in the middle-aged and the elderly. Once osteoarthritis develops, the joint cartilage will gradually wear away whereas with rheumatoid arthritis, the joint cartilage wears away more quickly and can occur at any age.