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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
What Are the Symptoms of Syphilis? There are three stages of syphilis. Call your doctor if you experience any of the following symptoms: In the first (primary) stage, which usually starts about three weeks after exposure, a painless sore called a chancre appears on the genitals, rectum, anus, or mouth. Lymph glands near the chancre may be swollen as well.