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Dependency, or addiction, is the most common of long-term heroin effects. Heroin is often considered the most addictive of all legal and illegal substances that are commonly abused for their mind-altering effects.
Painkiller abuse has serious short and long term effects. Though painkiller abuse can bring a temporary good feeling, it can also have negative consequences such as addiction, brain damage, or death.n addition to their short-term effects, pain meds can have serious long-term consequences for those who abuse them: 1  Tolerance for painkillers, meaning a normal, safe dose no longer controls pain. 2  A greater risk for abusing or becoming addicted to other drugs, especially in young people.