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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
Symptoms for the secondary stage of syphilis usually appear 2-8 weeks after first sore. Most people with syphilis get their second wave of symptoms anywhere from 2 to 8 weeks after the first chancre forms. This secondary stage of infection is the second of four stages. 33% of people who don't treat primary stage syphilis with antibiotics stay infected with secondary stage for up to a year.