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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
Phospholipids with certain head groups can alter the surface chemistry of a bilayer and can, for example, serve as signals as well as anchors for other molecules in the membranes of cells.ome molecules or particles are too large or too hydrophilic to pass through a lipid bilayer. Other molecules could pass through the bilayer but must be transported rapidly in such large numbers that channel-type transport is impractical.