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Drug-induced hypothyroidism may be caused by: 1  Drugs used for hyperthyroidism (overactive thyroid), such as propylthiouracil (PTU), radioactive iodine, potassium iodide, and methimazole. 2  Treatment with lithium or iodides in certain people.
Lithium is a medication used in the treatment for certain psychiatric disorders. However, lithium prevents thyroid hormone release and can cause hypothyroidism. The hypothyroidism is usually mild (subclinical). This typically happens within the first two years of starting lithium. Risk factors include female gender, elderly patients, and the presence of underlying autoimmune thyroiditis.