Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
That said, the key difference between rheumatoid arthritis and osteoarthritis is the cause behind how the joints are affected. Osteoarthritis is a slow and progressive degenerative joint disease, that is, it will slowly develop over years of wear-and-tear on the joints and cartilage.
All of these effects result in pain, stiffness and trouble moving the joint, and inflammation. Osteoarthritis is most frequently diagnosed in the hands, knees, hips and spine. Osteoarthritis differs from another type of arthritis called rheumatoid arthritis. Although they are both forms of arthritis, osteoarthritis and rheumatoid arthritis require different treatments.