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The sciatic nerve is the longest and largest nerve in the body; it measures three-quarters of an inch in diameter. It originates in the sacral plexus; a network of nerves in the low back (lumbosacral spine). The lumbosacral spine refers to the lumbar spine and the sacrum combined.he sciatic nerve starts in your low back, which is called your lumbar spine. The nerve roots are at the L4 and L5 vertebrae (the 'L' means lumbar, and the numbers indicate the level of the vertebraâwhere it is in your back). The sciatic nerve also travels through your pelvic region (sacrum).
1 It innervates muscles in the arm that extend the elbow and muscles in the forearm, which enables the wrist and fingers to straighten or extend.  Sciatic nerve â The sciatic nerve is the largest single nerve in the body, extending from the back of the pelvis down the back of the thigh. It is the primary nerve of the leg and is responsible for innervating the muscles in the hip and lower limbs (including the tibial nerve and common fibular nerve).