Several reports demonstrate unexplained consequences of mutations on the expression of the different dystrophin isoforms and their balance. The most prominent example is found in some cases of X-linked dilated cardiomyopathy (XLDC).
In particular, calcitonin has the ability to decrease blood calcium levels at least in part by effects on two well-studied target organs: 1  Bone: Calcitonin suppresses resorption of bone by inhibiting the activity of osteoclasts, a cell type that digests bone matrix, releasing calcium and phosphorus into blood.
An increase in blood calcium stimulates calcitonin, a hormone synthesized in the thyroid gland. This hormone lowers blood calcium by inhibiting bone resorption. Calcitonin's physiological function as a regulator of blood calcium levels is relatively minor compared to the actions of PTH and calcitriol.