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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
Symptoms of syphilis may vary with each stage of the infection. The infection has its time of activity and inactivity. When it is active, it may cause bouts of symptoms, and not when otherwise. In some cases, the stages may overlap, and the symptoms may not surface in an usual manner.