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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
insulin resistance. insulin resistance n. A state of diminished effectiveness of insulin in lowering the levels of blood sugar, usually resulting from insulin binding by antibodies, and associated with such conditions as obesity, ketoacidosis, and infection.