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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
Early Signs and Symptoms of Insulin Resistance. Many of the early symptoms of insulin resistance go unnoticed because they are typically labeled something else. These are some of the symptoms that are possible. hypoglycemia or low blood sugar. mood swings - which are triggered by erratic changes in blood sugar. chronic fatigue or low energy.