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Drug-induced hypothyroidism may be caused by: 1  Drugs used for hyperthyroidism (overactive thyroid), such as propylthiouracil (PTU), radioactive iodine, potassium iodide, and methimazole. 2  Treatment with lithium or iodides in certain people.
1 There are many disorders that result in hypothyroidism, for example, autoimmune disorders, thyroid removal, prescription medications, pituitary disease, and iodine deficiency.  The thyroid gland is regulated by another gland that is located in the brain, the pituitary.