Several reports demonstrate unexplained consequences of mutations on the expression of the different dystrophin isoforms and their balance. The most prominent example is found in some cases of X-linked dilated cardiomyopathy (XLDC).
In particular, calcitonin has the ability to decrease blood calcium levels at least in part by effects on two well-studied target organs: 1  Bone: Calcitonin suppresses resorption of bone by inhibiting the activity of osteoclasts, a cell type that digests bone matrix, releasing calcium and phosphorus into blood.
However, the importance of this role in humans is unclear, as patients who have very low or very high levels of calcitonin show no adverse effects. Calcitonin reduces calcium levels in the blood by two main mechanisms: 1  It inhibits the activity of osteoclasts, which are the cells responsible for breaking down bone. 2  It can also decrease the resorption of calcium in the kidneys, again leading to lower blood calcium levels.