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Itâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.tâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.
What is Fluzone High-Dose vaccine? Fluzone High-Dose is a vaccine that helps protect against influenza illness (flu). Fluzone High-Dose vaccine is for people 65 years of age and older. Vaccination with Fluzone High-Dose vaccine may not protect all people who receive the vaccine. Who should not get Fluzone High-Dose vaccine?