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Very rarely, eye twitching may be a sign of certain brain and nervous system disorders. When it is, it's almost always accompanied by other signs and symptoms. Brain and nervous system disorders that can cause eye twitching include: Bell's palsy.
The most common known causes of eye twitch include fatigue, stress, anxiety, and excessive caffeine intake. Eyelid twitch may appear in response to irritation caused by smoke, dust, or a foreign body in the eye. Allergies and infections may also cause irritation that leads to twitching. Eyelid twitch is seen in primary congenital glaucoma.