Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
That said, the key difference between rheumatoid arthritis and osteoarthritis is the cause behind how the joints are affected. Osteoarthritis is a slow and progressive degenerative joint disease, that is, it will slowly develop over years of wear-and-tear on the joints and cartilage.
This ridge may restrict movement of the joint. Osteoarthritis is less crippling than rheumatoid arthritis, in which two bone surfaces may fuse, completely immobilizing the joint. Treatment is aimed at preventing crippling deformities, relieving pain, and maintaining motion of the joint; see also treatment of arthritis.