Several reports demonstrate unexplained consequences of mutations on the expression of the different dystrophin isoforms and their balance. The most prominent example is found in some cases of X-linked dilated cardiomyopathy (XLDC).
In particular, calcitonin has the ability to decrease blood calcium levels at least in part by effects on two well-studied target organs: 1  Bone: Calcitonin suppresses resorption of bone by inhibiting the activity of osteoclasts, a cell type that digests bone matrix, releasing calcium and phosphorus into blood.
DRUG CLASS: Calcitonin salmon is a man-made version of the hormone, calcitonin, that is found in salmon. Calcitonin is used for treating postmenopausal (after menopause) osteoporosis (bone loss), Paget's disease of bone, and hypercalcemia (high blood calcium levels). In humans, calcitonin is produced by the thyroid gland. It acts primarily on bone, but the mechanism of its action is not well understood. Bone is in a constant state of remodeling, whereby old bone is broken-down by cells called osteoclasts, and new bone is laid down by cells called osteoblasts.