In winter, the weather outside is cold and people are dressed warmly, so a much lower indoor temperature such as 62 feels warm enough. In summer when wearing light clothes, cold AC is absolutely miserable! Summer indoor temperatures should be between 80 and 86 degrees.
The pinprick pupils are caused by mu receptor activation, and reversed (as we all know) during mu receptor antagonism or withdrawal. The pupil size is a good indicator of the subjective experience. If a person has low or no opiate tolerance, buprenorphine will cause the person to feel an opiate 'high', and will constrict the pupils. If a person is taking buprenorphine every day, appropriately, there is no high, and the pupils are not affected. If a person is using high doses of oxycodone or heroin and takes buprenorphine, the person will feel lousy, i.e.precipitated withdrawal, and the pupils will be very large.
Buprenorphine is used to treat opioid addiction. Buprenorphine is an opioid partial agonist medication used for the treatment of opioid addiction. Opioid. partial agonists are drugs that activate opioid receptors but to a lesser degree than opioid agonists like. heroin or methadone. Buprenorphine has a strong affinity to opioid receptors and displaces other opioids.