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Quick Answer. High PSA levels may indicate prostate cancer, prostatitis or an enlarged prostate, states WebMD. PSA levels in men naturally increase with age. In most cases, a PSA level under 4 nanograms per milliliter is considered normal, and men with this result have a low chance of prostate cancer. Continue Reading.
1 Total PSA levels between 4.0 ng/ml and 10.0 ng/ml may indicate prostate cancer (about a 25% chance, according to the ACS), benign prostate hyperplasia (BPH) , or inflammation of the prostate. 2  These conditions are more common in the elderly, as is a general increase in PSA levels.hile elevated PSA levels are associated with cancer, they may be caused by other conditions, such as benign prostatic hyperplasia (BPH) and inflammation of the prostate. An elevated PSA may be followed by a biopsy, which has risk of complications such as pain, fever, blood in the urine, or urinary tract infection.