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Quick Answer. High PSA levels may indicate prostate cancer, prostatitis or an enlarged prostate, states WebMD. PSA levels in men naturally increase with age. In most cases, a PSA level under 4 nanograms per milliliter is considered normal, and men with this result have a low chance of prostate cancer. Continue Reading.
Prostate Specific Antigen Prostate specific antigen (PSA) is a protein that is found in the semen. PSA levels are used to detect prostate cancer and monitor the progression of the disease. A condition called benign prostatic hypertrophy (BPH) can also cause elevated PSA levels.