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Itâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.tâs not entirely clear why the length of acquired protection varies with different vaccines. A single dose of some vaccines provides lifelong immunity, while others require an additional dose (boosters) in order to maintain immunity.
To produce an immune response, live attenuated vaccines. must replicate (grow) in the vaccinated person. A relatively. small dose of virus or bacteria is administered, which. replicates in the body and creates enough of the organism. to stimulate an immune response.lassification of Vaccines There are two basic types of vaccines: live attenuated and inactivated. The characteristics of live and inactivated vaccines are different, and these characteristics determine how the vaccine is used.