Several reports demonstrate unexplained consequences of mutations on the expression of the different dystrophin isoforms and their balance. The most prominent example is found in some cases of X-linked dilated cardiomyopathy (XLDC).
In particular, calcitonin has the ability to decrease blood calcium levels at least in part by effects on two well-studied target organs: 1  Bone: Calcitonin suppresses resorption of bone by inhibiting the activity of osteoclasts, a cell type that digests bone matrix, releasing calcium and phosphorus into blood.
Human or salmon calcitonin has no significant effects on blood pressure (18) but salmon calcitonin induces negative chronotropic and negative inotropic effects on isolated dog atrium (19), suggesting that it has a possible role in the regulation of myocardial contractile force and rate.