Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well.Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.stradiol, or more precisely, 17Î²-estradiol, is a steroid and estrogen sex hormone, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles.
The first computer retail store ordered fifty Apple I computers: this was their first sale. Jobs and Wozniak started working out of Jobs' parents house in Cupertino, California. In their first year as Apple Computer, they moved from the garage to a room in Cupertino.
Though Steve Jobs founded Apple in 1976, he left in 1985 amid a power struggle. In 1996, Jobs returned when Apple bought his company NeXt. Here, he announces plans to shake the company out of the financial doldrums on Nov. 10, 1997, in Cupertino, Calif. Photograph by John G. Mabanglo/AFP/Getty Images.