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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
This form of neurosyphilis is also rare. It can start to affect the spinal cord 20 years or more after the initial syphilis infection. Its symptoms include difficulties with balance, loss of coordination, incontinence, an altered walk, vision problems, and pains in the abdomen, arms, and legs.