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Skin, mouth, genital symptoms â One characteristic feature of acute HIV infection is open sores or ulcers. These sores or ulcers can develop in the mouth, the esophagus (the tube that extends from the mouth to the stomach), the anus, or the penis. The ulcers are usually painful.
A: The earliest signs of an HIV infection are flu-like symptoms that include fever, rash, swollen lymph nodes, headache and fatigue, according to Mayo Clinic. These symptoms usually appear between 30 and 60 days after a person has been infected, and they may be mistaken for another viral infection.