Several reports demonstrate unexplained consequences of mutations on the expression of the different dystrophin isoforms and their balance. The most prominent example is found in some cases of X-linked dilated cardiomyopathy (XLDC).
In particular, calcitonin has the ability to decrease blood calcium levels at least in part by effects on two well-studied target organs: 1  Bone: Calcitonin suppresses resorption of bone by inhibiting the activity of osteoclasts, a cell type that digests bone matrix, releasing calcium and phosphorus into blood.
Transcript of Aconite. Aconite. Effects on the Body. Immediate sensation of burning, tingling, and numbness in the mouth. Burning in the abdomen. Numbness in the throat and difficulty with speech usually follow. After an hour, there is severe vomiting followed by motor weakness. The pulse and respiration steadily fail until death occurs.