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Description of Trazodone. Trazodone: oral antidepressant (trade name Desyrel) that is a nontricyclic drug used as a sedative. Trazodone: A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants.
Trazodone is the most sedating, and least anticholinergic, of all the currently marketed antidepressants. The therapeutic effects of trazodone, like other antidepressants, appear slowly. Maximum benefit is often not evident for at least two weeks after starting the drug.