DNA polymerases need a primer oligonucleotide (RNA or DNA) - their substrates are an existing 3'-OH group and a dNTP. The primase however is a typical RNA polymerase, capable of initiating polynucleotide synthesis de novo by positioning a complementary ribonucleoside 5'-triphosphate opposite its complementary DNA base.
Alison Schapker. Alison Schapker is an American television writer and producer. She is well known for her work on the ABC espionage series Alias and for the FOX science-fiction series Fringe.
Stephen Schueler, MD, is an emergency physician, teacher, and author. Although he designed the Symptom Checker to feel like a real emergency room intake interview, it is a computer program and not a live doctor. Its recommendations should not be used as a basis for delaying, or as a substitute for, evaluation and treatment by a physician.