These problems can be mitigated through the process of design, which is an intellectual approach that emphasizes empathy, abductive reasoning, and rapid prototyping. Horst Rittel, one of the first to formalize a theory of wicked problems, cites ten characteristics of these complicated social issues Rittel, Horst. Dilemmas in a General Theory of Planning.. Policy Sciences, 1973: 155-169.
Changes in blood pressure and volume are not nearly as sensitive a stimulator as increased osmolarity, but are nonetheless potent in severe conditions. For example, Loss of 15 or 20% of blood volume by hemorrhage results in massive secretion of antidiuretic hormone.
1 Pressure Natriuresis: If renal perfusion pressure is increased then sodium excretion increases i.e. sodium excretion increases when blood pressure increases. 2  If more sodium is excreted less water is reabsorbed therefore the ECF volume decreases and blood pressure decreases.