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Causes of urinary tract infections. The vast majority of UTI cases are caused by the bacterium Escherichia coli (E. coli), usually found in the digestive system. Chlamydia and Mycoplasma bacteria can infect the urethra but not the bladder.
The most common cause of UTIs are bacteria from the bowel that live on the skin near the rectum or in the vagina, and which can spread and enter the urinary tract through the urethra. Once these bacteria enter the urethra, they travel up, causing infection in the bladder and sometimes other parts of the urinary tract.