In the initial âexpandingâ phase, lymphatic fluid flows at an increased rate and volume from an affected joint to the draining LN via afferent lymphatic vessels. The LN volume expands, presumably to accommodate the influx of cells and lymph exiting the inflamed synovium.
Other signs and symptoms of COPD may include: 1  Shortness of breath, especially during physical activities. 2  Wheezing. 3  Chest tightness.  Having to clear your throat first thing in the morning, due to excess mucus in your 1  lungs. A chronic cough that may produce mucus (sputum) that may be clear, white, yellow or greenish.
The earliest symptom of COPD is shortness of breath with activity. The earliest symptom of chronic bronchitis is a frequent cough with mucus production. Later symptoms of COPD include shortness of breath with activity and even at rest. A cough and phlegm may also be present. Sometimes it is hard to know what to do when your symptoms change or worsen.