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Typhoid fever is treated with antibiotics which kill the Salmonella bacteria. Prior to the use of antibiotics, the fatality rate was 20%. Death occurred from overwhelming infection, pneumonia, intestinal bleeding, or intestinal perforation. With antibiotics and supportive care, mortality has been reduced to 1%-2%.
How typhoid fever is treated. Typhoid fever requires prompt treatment with antibiotics. If diagnosed at an early stage, the infection is likely to be mild and can usually be treated at home with a 7- to 14-day course of antibiotic tablets.