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In the. stomach, alcohol interferes with gastric acid secretion and with the activity of the. muscles surrounding the stomach. Similarly, alcohol may impair the muscle. movement in the small and large intestines, contributing to the diarrhea frequently.
1 On an empty stomach, alcohol passes directly to the blood stream.  Drinking too much alcohol stimulates gastric juice flow. Higher alcohol content can cause stomach lining irritation and lead to ulcers.