It also regulates the amount of water released from the body into the atmosphere through transepidermal water loss (TEWL). In humans, it is thinnest on the eyelids at 0.05 mm (0.0020 in) and thickest on the palms and soles at 1.5 mm (0.059 in).
When opiates are prescribed by a physician for the treatment of pain and are taken in the prescribed dosage, they are safe and there is little chance of opiate addiction. However, when opiates are abused and taken in excessive doses, opiate addiction can result, leading to a need for rapid detoxification.wo important effects produced by opiates, such as morphine, are pleasure (or reward) and pain relief. The brain itself also produces substances known as endorphins that activate the opiate receptors.
These drugs include narcotics and non-steroidal anti-inflammatory drugs (NSAIDs). Although the terminology is not precisely correct, pain-relieving opioids are often called narcotics, and they may be prescribed to treat acute pain (severe, short-lived pain), post-operative pain and certain types of chronic pain.