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White matter is located at the base of the brain between the cerebellum and the brainstem. It is made of long nerve fibers called axons. The axons are insulated by myelin, sheaths of fat that give the region the white color for which it is named. The myelin helps speed up the transmission of signals along the axons.
The exterior of the brain stem consists of white matter that conducts nerve signals within the brain stem and to the spinal cord and other regions of the brain. Masses of gray matter, known as nuclei, perform the processing role of the brain stem. The reticular formation, a network of mixed gray and white matter, extends throughout the interior of the brain stem and plays an important role in stimulation of the cerebrum and the muscles of the body.