DNA polymerases need a primer oligonucleotide (RNA or DNA) - their substrates are an existing 3'-OH group and a dNTP. The primase however is a typical RNA polymerase, capable of initiating polynucleotide synthesis de novo by positioning a complementary ribonucleoside 5'-triphosphate opposite its complementary DNA base.
Alison Schapker. Alison Schapker is an American television writer and producer. She is well known for her work on the ABC espionage series Alias and for the FOX science-fiction series Fringe.
Director of U.S. National Intelligence James Clapper speaks during a discussion on The 9/11 Commission Report: Ten Years Later, hosted by The Bipartisan Policy Center (BPC) and the Annenberg Public Policy Center of the University of Pennsylvania, July 22, 2014 at the Newseum in Washington, DC. Alex Wong, Getty Images.