duete; see due, ty 2 ]. syn: duty, obligation refer to something a person feels bound to do. A duty often applies to what a person performs in fulfillment of the permanent dictates of conscience, piety, right, or law: one's duty to tell the truth; a parent's duty to raise children properly.
Mutations in the RB1 gene are responsible for most cases of retinoblastoma. RB1 is a tumor suppressor gene, which means that it normally regulates cell growth and keeps cells from dividing too rapidly or in an uncontrolled way.
Sideroblastic anemia can be caused by hereditary factors, acquired as part of an underlying condition or exposure to drugs or toxins, or the cause may be unknown (idiopathic). Hereditary causes of sideroblastic anemia include: 1  Mutations in the ALAS2, ABCB7, SCL19A2, GLRX5, and PSU1 genes. 2  Pearson syndrome. 3  Wolfram or DIDMOAD syndrome. 4  Mitochondrial SLC25A38. 5  Erythropoietic protoporphyria.