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Answers. Best Answer: Primary nondisjunction can happen during meiosis when the chromosomes fail to separate as they should. This produces gametes with more than or less than the usual number of chromosomes. Secondary nondisjunction happens during meiosis in an individual whose chromosomes are already the wrong number because of nondisjunction. So, primary nondisjunction could produce a gamete with two Xs and a zygote with XXY. When this person matures and produces gametes, secondary nondisj.
Nondisjunction in mitosis or meiosis is the cause of most aneuploids. Disjunction is the normal separation of homologous chromosomes or chromatids to opposite poles at nuclear division. Nondisjunction is a failure of this disjoining process, and two chromosomes (or chromatids) go to one pole and none to the other.ondisjunction in mitosis or meiosis is the cause of most aneuploids. Disjunction is the normal separation of homologous chromosomes or chromatids to opposite poles at nuclear division. Nondisjunction is a failure of this disjoining process, and two chromosomes (or chromatids) go to one pole and none to the other.