General bacterial porin family. General bacterial porins are a family of proteins from the outer membranes of Gram-negative bacteria. The porins act as molecular filters for hydrophilic compounds. They are responsible for the 'molecular sieve' properties of the outer membrane. Porins form large water-filled channels which allow the diffusion of hydrophilic molecules into the periplasmic space. Some porins form general diffusion channels that allow any solute up to a certain size to cross the membrane, while other porins are sp
Cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene. CFTR is an ABC transporter-class ion channel that codes for a protein that conducts chloride and thiocyanate ions across epithelial cell membranes.
1 Deletion of Phe508 in cystic fibrosis transmembrane conductance regulator causes cystic fibrosis; only coexpression with wild-type N-half promotes maturation of C-half of CFTR. 2  Genetic mutations may be grouped by class (I-VI) and are related to quantity of CFTR protein produced. The frameshift mutation 3905insT is one of the most common CFTR mutations in the Swiss population with cystic fibrosis. 2  Structure and dynamics of NBD1 from CFTR. 3  These results suggest the possibility of an interaction between CFTR and the TJ protein complex, probably via the cytoskeleton.