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DOSAGE AND ADMINISTRATION. The dosage of ZYLOPRIM (allopurinol) to accomplish full control of gout and to lower serum uric acid to normal or near-normal levels varies with the severity of the disease.The average is 200 to 300 mg/day for patients with mild gout and 400 to 600 mg/day for those with moderately severe tophaceous gout.OSAGE AND ADMINISTRATION. The dosage of ZYLOPRIM (allopurinol) to accomplish full control of gout and to lower serum uric acid to normal or near-normal levels varies with the severity of the disease.
For patients with renal impairment, where the eGFR is less than 30 mL/min/1.73 m 2, it is recommended that the starting dose of allopurinol is reduced to 50 mg per day, or every second day, and then increased by 50 mg every month as guided by the serum urate levels and tolerance.or people who are intolerant to allopurinol give probenecid 250 mg, twice daily for one week, increasing to 500 mg, twice daily. Dose can be increased by 500 mg per month to a maximum of 2000 mg daily in divided doses. Increase fluid intake to prevent renal stone formation.