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Sclerodermaâs main types are localized and systemic. Localized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs.3  It may get better or go away without help.4  But it can be severe in some people and can leave skin damage.ocalized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs. 3  It may get better or go away without help. 4  But it can be severe in some people and can leave skin damage.
Disease-modifying antirheumatic drugs (DMARDs) are a varied group of medications that suppress inflammation-causing chemicals to prevent joint damage and reduce symptoms. Most are taken by mouth. According to the American College of Rheumatology, DMARDs most commonly prescribed for psoriatic arthritis are methotrexate, sulfasalazine, cyclosporine and leflunomide. Azathioprine may also be prescribed. Apremilast is a newer DMARD approved in 2014.