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Sclerodermaâs main types are localized and systemic. Localized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs.3  It may get better or go away without help.4  But it can be severe in some people and can leave skin damage.ocalized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs. 3  It may get better or go away without help. 4  But it can be severe in some people and can leave skin damage.
How Is Scleroderma Treated? Thereâs no treatment for scleroderma, but you can manage the symptoms. Your doctor will focus on helping you do that with: NSAIDs (nonsteroidal anti-inflammatory drugs like ibuprofen or aspirin). They can help with swelling and pain. Steroids and other drugs to control your immune response.