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Answers. Best Answer: Primary nondisjunction can happen during meiosis when the chromosomes fail to separate as they should. This produces gametes with more than or less than the usual number of chromosomes. Secondary nondisjunction happens during meiosis in an individual whose chromosomes are already the wrong number because of nondisjunction. So, primary nondisjunction could produce a gamete with two Xs and a zygote with XXY. When this person matures and produces gametes, secondary nondisj.
Article draft and notes. Nondisjunction is the failure of chromosome pairs to separate properly during meiosis or mitosis. The result of this error is that a chromosome(s) is lost (or gained). When a chromosome is lost, it is called a Monosomy, in which the gamete with the defect will have 1 or more chromosomes missing from one of its pairs.