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Drug Therapy. 1  Iron supplements. To get more iron into your blood to help it carry oxygen if you show signs of anemia. 2  Ibuprofen (Advil). To help reduce pain, menstrual cramps, and the amount of bleeding. 3  Birth control pills. To help make periods more regular and reduce the amount of bleeding. 4  Intrauterine contraception (IUC).
Both aspirin and nonsteroidal anti-inflammatory medications (NSAIDs), such as ibuprofen (Motrin IB, Advil, others) and naproxen sodium (Aleve), reduce the clotting action of blood platelets. Regular use of nonsteroidal anti-inflammatory medications can increase your bleeding risk. Some NSAIDs can increase the risk of heart attacks on their own. Additionally, some NSAIDs can adversely interact with aspirin, increasing the risk of bleeding even more. If you need only a single dose of ibuprofen, take it two hours after the aspirin.