Multiple myeloma is staged by estimating the myeloma tumor cell mass on the basis of the amount of monoclonal (or myeloma) protein (M protein) in the serum and/or urine, along with various clinical parameters, such as hemoglobin and serum calcium concentrations, the number of lytic bone lesions, and the presence or absence of renal failure.
At present, daylight saving time in the United States. 1  begins at 2:00 a.m. on the second Sunday of March and. 2  ends at 2:00 a.m. on the first Sunday of November.
Daylight saving begins at 2 a.m. for many good reasons, such as most people are at home in bed. Credit: Clock image via Shutterstock | T.W. View full size image. Few people will likely wake up exactly at 2:00 a.m. local time to move the clock hand, or dial, forward an hour. But that's when daylight saving time officially begins on the second Sunday in March. It ends on the first Sunday in November, when clocks are turned back at 2:00 a.m. local time to read 1:00 a.m. That is, for everyone except those who live in Hawaii, American Samoa, Guam, Puerto Rico, the Virgin Islands, and by most of Arizona, with the exception of the Navajo Nation.