It also regulates the amount of water released from the body into the atmosphere through transepidermal water loss (TEWL). In humans, it is thinnest on the eyelids at 0.05 mm (0.0020 in) and thickest on the palms and soles at 1.5 mm (0.059 in).
When opiates are prescribed by a physician for the treatment of pain and are taken in the prescribed dosage, they are safe and there is little chance of opiate addiction. However, when opiates are abused and taken in excessive doses, opiate addiction can result, leading to a need for rapid detoxification.wo important effects produced by opiates, such as morphine, are pleasure (or reward) and pain relief. The brain itself also produces substances known as endorphins that activate the opiate receptors.
When taken as prescribed, methadone can be very useful in treating opiate addiction, but it too can be addictive, as it is still an opiate. When used as a treatment to wean individuals off other drugs of addiction, methadone prescriptions and use are closely supervised by medical professionals.