It also regulates the amount of water released from the body into the atmosphere through transepidermal water loss (TEWL). In humans, it is thinnest on the eyelids at 0.05 mm (0.0020 in) and thickest on the palms and soles at 1.5 mm (0.059 in).
When opiates are prescribed by a physician for the treatment of pain and are taken in the prescribed dosage, they are safe and there is little chance of opiate addiction. However, when opiates are abused and taken in excessive doses, opiate addiction can result, leading to a need for rapid detoxification.wo important effects produced by opiates, such as morphine, are pleasure (or reward) and pain relief. The brain itself also produces substances known as endorphins that activate the opiate receptors.
Washington Stateâs guideline on use of opioids for. chronic non-cancer painâfrequently asked questions. Washington State health officials published the two-part guideline in 2010 to. help providers prescribe opioids, or narcotics, for chronic non-cancer pain in a. safe and effective manner. The guideline is intended as an educational aid for. primary care providers treating adult patients.