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Physical dependence on drugs is marked by growing tolerance of a drug's effects, so that increased amounts of the drug are needed to obtain the desired effect, and by the onset of withdrawal symptoms over periods of prolonged abstinence.hysical dependence on drugs is marked by growing tolerance of a drug's effects, so that increased amounts of the drug are needed to obtain the desired effect, and by the onset of withdrawal symptoms over periods of prolonged abstinence.
These behavioral changes are also accompanied by changes in brain functioning, especially in the brainâs natural inhibition and reward centers. NIDAâs use of the term addiction corresponds roughly to the DSM definition of substance use disorder. The DSM does not use the term addiction. What is the difference between physical dependence, dependence, and addiction?