These problems can be mitigated through the process of design, which is an intellectual approach that emphasizes empathy, abductive reasoning, and rapid prototyping. Horst Rittel, one of the first to formalize a theory of wicked problems, cites ten characteristics of these complicated social issues Rittel, Horst. Dilemmas in a General Theory of Planning.. Policy Sciences, 1973: 155-169.
Changes in blood pressure and volume are not nearly as sensitive a stimulator as increased osmolarity, but are nonetheless potent in severe conditions. For example, Loss of 15 or 20% of blood volume by hemorrhage results in massive secretion of antidiuretic hormone.
The hormones parathyroid hormone (PTH) and calcitonin help regulate blood calcium levels. Calcitonin, secreted by the thyroid gland inhibits osteoclasts and stimulates osteoblasts, thus decreasing blood calcium levels. Parathyroid hormone is secreted by the parathyroid glands, which are on the posterior side of the thyroid. Parathyroid hormone inhibits osteoblasts, stimulates osteoclasts, reduces the output of calcium by the kidneys and promotes the absorption of calcium by the small intestines, thus increasing blood calcium levels.