It also regulates the amount of water released from the body into the atmosphere through transepidermal water loss (TEWL). In humans, it is thinnest on the eyelids at 0.05 mm (0.0020 in) and thickest on the palms and soles at 1.5 mm (0.059 in).
When opiates are prescribed by a physician for the treatment of pain and are taken in the prescribed dosage, they are safe and there is little chance of opiate addiction. However, when opiates are abused and taken in excessive doses, opiate addiction can result, leading to a need for rapid detoxification.wo important effects produced by opiates, such as morphine, are pleasure (or reward) and pain relief. The brain itself also produces substances known as endorphins that activate the opiate receptors.
Long-acting opiate pain relievers are medicines used to relieve moderate to severe long-term pain. They are also called extended-release opiates. Opiates relieve pain by changing the way your body feels pain.They don't cure a health problem, but they help you manage the pain.If you take a lot of short-acting medicine, your doctor may give you long-acting opiates.Long-acting opiates help you avoid the ups and downs in pain relief that you may have with short-acting medicine.o use long-acting opiates safely: 1  Call your doctor if you think you are having a problem with your medicine. 2  You will get more details on the specific medicines your doctor prescribes. 3  Do not drink alcohol or take illegal drugs. 4  Do not drive or operate machinery until you can think clearly.