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The term ' Activated Partial Thromboplastin Time ( APTT ) ' derives from the original form of the test ( devised in 1953 ) in which only the phospholipid concentration of the test was controlled ( as opposed to the phospholipid and the surface activator concentrations ) and the name ' partial thromboplastin ' was applied at the time to phospholipid ...
1 The partial thromboplastin time (PTT) and activated partial thromboplastin time (APTT) may be normal in people who have inherited bleeding disorders but have only mild symptoms. 2  The APTT is used to check treatment of people who are using heparin or other blood-thinning medicine to prevent blood clots. A longer-than-normal PTT or APTT can be caused by liver disease, kidney disease (such as nephrotic syndrome), or treatment with blood thinners, such as heparin or warfarin (Coumadin). 2  A longer-than-normal PTT may be caused by conditions such as antiphospholipid antibody syndrome or lupus anticoagulant syndrome.