These problems can be mitigated through the process of design, which is an intellectual approach that emphasizes empathy, abductive reasoning, and rapid prototyping. Horst Rittel, one of the first to formalize a theory of wicked problems, cites ten characteristics of these complicated social issues Rittel, Horst. Dilemmas in a General Theory of Planning.. Policy Sciences, 1973: 155-169.
Increased ADH levels are often associated with SIADH, which may be due to a variety of cancers, including leukemia, lymphoma, and cancers of the lung, pancreas, bladder, and brain. Levels of ADH may be greatly increased with such cancers.
Drug-induced extrapyramidal reactions. Parkinsonism monotherapy: initially 100mg twice daily, may increase after 1â2 weeks by 100mg daily. Serious associated illness or high doses of other antiparkinson drugs: 100mg once daily, may increase after 1 to several weeks to 100mg twice daily; max 400mg/day in divided doses. Extrapyramidal disorders: 100mg twice daily; max 300mg/day in divided doses. Renal dysfunction: reduce dose; see literature.