In the initial âexpandingâ phase, lymphatic fluid flows at an increased rate and volume from an affected joint to the draining LN via afferent lymphatic vessels. The LN volume expands, presumably to accommodate the influx of cells and lymph exiting the inflamed synovium.
Other signs and symptoms of COPD may include: 1  Shortness of breath, especially during physical activities. 2  Wheezing. 3  Chest tightness.  Having to clear your throat first thing in the morning, due to excess mucus in your 1  lungs. A chronic cough that may produce mucus (sputum) that may be clear, white, yellow or greenish.
According to the Global Initiative for Obstructive Lung Disease, the hallmark symptoms of COPD are progressively worsening dyspnea, chronic cough and sputum production. However, cough and sputum production may be present long before airflow limitation, one of the primary characteristics of COPD, develops.