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White matter is located at the base of the brain between the cerebellum and the brainstem. It is made of long nerve fibers called axons. The axons are insulated by myelin, sheaths of fat that give the region the white color for which it is named. The myelin helps speed up the transmission of signals along the axons.
White matter and grey matter also differ in terms of distribution. In the brain, grey matter is found on the surface of the cerebral and cerebellar cortices. It is also found in the deeper parts of the cerebrum, particularly the basal ganglia, thalamus, hypothalamus, and different subthalamic nuclei.