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In the. stomach, alcohol interferes with gastric acid secretion and with the activity of the. muscles surrounding the stomach. Similarly, alcohol may impair the muscle. movement in the small and large intestines, contributing to the diarrhea frequently.
1 Around two hours after the stomach has been emptied, it sends signals to the brain, which tells the digestive muscles to restart peristalsis in a wave called the migrating motor complex. 2  Food left behind after the first cycle is swept up, and the vibrations of the empty stomach cause hunger.