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Calf muscle pain can be due to injury, underlying medical condition or a problem in the nerves or arteries in the lower leg. Whilst often something minor like a grade one muscle strain, the problem may not actually be in the muscle itself and could be indicative of a serious problem such as a DVT so should always be treated with caution.
Calf pain in the absence of trauma or other symptoms is commonly due to a muscle cramp, also called a âcharley horse.â However, there are more serious conditions that lead to calf pain, such as peripheral artery disease.f you, or someone you are with, are experiencing calf or leg pain after mild exercise or exertion, or if you are experiencing pain, swelling, redness, and warmth in the calf, seek immediate medical care (call 911) . 9 Things to Know About Cortisone Injections. What Your Joint Pain Could Mean.