In the initial âexpandingâ phase, lymphatic fluid flows at an increased rate and volume from an affected joint to the draining LN via afferent lymphatic vessels. The LN volume expands, presumably to accommodate the influx of cells and lymph exiting the inflamed synovium.
Other signs and symptoms of COPD may include: 1  Shortness of breath, especially during physical activities. 2  Wheezing. 3  Chest tightness.  Having to clear your throat first thing in the morning, due to excess mucus in your 1  lungs. A chronic cough that may produce mucus (sputum) that may be clear, white, yellow or greenish.
Chronic Cough Is the First Symptom. Cough is the first sign of COPD. According to the Mayo Clinic, COPD is diagnosed if your cough is persistent for three months (or longer) out of a year for at least two years. The cough may persist every day, even if there are no other symptoms of illness, such as a cold or the flu.