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Description of Trazodone. Trazodone: oral antidepressant (trade name Desyrel) that is a nontricyclic drug used as a sedative. Trazodone: A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants.
In the other case, it was reported that acute dystonia observed 2 weeks after the dose of trazodone had been increased to 50 mg/day (7). There was also no case of tardive dyskinesia reported with trazodone (5). Trazodone has generally antagonistic effect on serotonergic receptors in particular 5-HT1A, 5-HT1C and 5-HT2.