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Definition of caustic. 1 : capable of destroying or eating away by chemical action : corrosive The chemical was so caustic that it ate through the pipe. 2 : marked by incisive sarcasm a caustic film review caustic humor.
2. (Chemistry) the composition, properties, and reactions of a particular substance. 3. the nature and effects of any complex phenomenon: the chemistry of humour. 4. a reaction, taken to be instinctual, between two persons.