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Description of Trazodone. Trazodone: oral antidepressant (trade name Desyrel) that is a nontricyclic drug used as a sedative. Trazodone: A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants.
How Trazodone Changes the Perception of Pain. Trazodone is a type of antidepressant that can be used to improve mood, reduce anxiety and promote a healthy sleep cycle. While trazodone is sometimes used as a regular antidepressant, it often has more negative side effects than newer antidepressants. However, it has significantly fewer side effects than traditional pain medications like morphine and oxycodone. Trazodone can help change the way the body perceives pain. By reducing depression, it's possible to minimize the negative mental effects pain has on a patient. However, trazodone is mostly used for people who experience chronic back pain or another long-term issue.