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In the. stomach, alcohol interferes with gastric acid secretion and with the activity of the. muscles surrounding the stomach. Similarly, alcohol may impair the muscle. movement in the small and large intestines, contributing to the diarrhea frequently.
So why do they say you shouldnât drink on an empty stomach? It all comes back to that nifty enzyme, alcohol dehydrogenase. 85% of the metabolism happens in the liver (that be why liver disease is common âmongst alcoholics) and 15% happens in the stomach where the enzyme is present in the lining.