In the initial âexpandingâ phase, lymphatic fluid flows at an increased rate and volume from an affected joint to the draining LN via afferent lymphatic vessels. The LN volume expands, presumably to accommodate the influx of cells and lymph exiting the inflamed synovium.
Other signs and symptoms of COPD may include: 1  Shortness of breath, especially during physical activities. 2  Wheezing. 3  Chest tightness.  Having to clear your throat first thing in the morning, due to excess mucus in your 1  lungs. A chronic cough that may produce mucus (sputum) that may be clear, white, yellow or greenish.
Shortness of breath and wheezing are present in many cases. Exacerbations may be accompanied by increased amount of cough and sputum productions, and a change in appearance of sputum. An abrupt worsening in COPD symptoms may cause rupture of the airways in the lungs, which in turn may cause a spontaneous pneumothorax. In infection, there is often weakness, fever and chills.