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In addition, some studies found that two or more cups of coffee a day can increase the risk of heart disease in people with a specific â and fairly common â genetic mutation that slows the breakdown of caffeine in the body. So, how quickly you metabolize coffee may affect your health risk.
If coffee drinking does increase the risk of heart disease, it may do so through its effect on cholesterol. A few studies have linked heavy coffee consumption to elevated total serum cholesterol, although caffeine alone does not seem to be responsible.