It also regulates the amount of water released from the body into the atmosphere through transepidermal water loss (TEWL). In humans, it is thinnest on the eyelids at 0.05 mm (0.0020 in) and thickest on the palms and soles at 1.5 mm (0.059 in).
When opiates are prescribed by a physician for the treatment of pain and are taken in the prescribed dosage, they are safe and there is little chance of opiate addiction. However, when opiates are abused and taken in excessive doses, opiate addiction can result, leading to a need for rapid detoxification.wo important effects produced by opiates, such as morphine, are pleasure (or reward) and pain relief. The brain itself also produces substances known as endorphins that activate the opiate receptors.
Opiates are powerful drugs derived from the poppy plant that have been used for centuries to relieve pain. Also known as narcotics, opiates can be natural or synthetic. The natural opiates include opium, morphine, and codeine. Other substances, called opioids, are man-made. These substances are like opiates in that they are most often used to treat chronic or severe pain and are also highly addictive.