Definition of retraction. Examples of retraction in a sentence. His charges were false, and he was forced to make a retraction. Then, last spring, Gabriel Arana, an editor at The American Prospect who had undergone several years of reparative therapy in his teens, called on Spitzer at his home in Princeton, New Jersey.
2010]. Grapefruit juice inhibited the first-pass metabolism of oxycodone by CYP3A4 enzymes in the liver; consequently, oxycodone plasma concentrations were significantly increased by 50% and the half-life was extended by 20%.
Drugs or toxins are broken down (metabolized) so that they can be eliminated from the body. Grapefruit juice decreases the activity of the cytochrome P450 3A4 (CYP3A4) enzymes that are responsible for breaking down many drugs and toxins. Grapefruit contains compounds known as furanocoumarins that block the CYP3A4 enzymes. When grapefruit juice is consumed, the enzymeâs ability to break down the drug for elimination is decreased. Blood levels of the drug may rise, resulting in the risk for new or worsened side effects.