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Silver sulfadiazine (INN, or silvadene) is a topical sulfonamide / silver antibacterial used as a topical cream on burns.Evidence regarding its usefulness in burns is poor.Tentative evidence has found that silver sulfadiazine may increase healing times â wounds may take longer to heal if treated with this drug, so it is not recommended by the authors of a Cochrane review.Silver sulfadiazine is typically delivered in a cream or aqueous suspension.entative evidence has found that silver sulfadiazine may increase healing times â wounds may take longer to heal if treated with this drug, so it is not recommended by the authors of a Cochrane review.
Silvadene Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form, which has the following structural formula: Each gram of Silvadene Cream 1% contains 10 mg of micronized silver sulfadiazine. The cream vehicle consists of white petrolatum, stearyl alcohol, isopropyl myristate, sorbitan monooleate, polyoxyl 40 stearate, propylene glycol, and water, with methylparaben 0.3% as a preservative.