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The most common cause of intrauterine growth restriction is an abnormality in the placenta. A placental abnormality can cause intrauterine growth restriction because the fetus may become malnourished.Some other potential causes include: 1  Congenital or chromosomal abnormalities. 2  Heart disease.3  Diabetes.he most common cause of intrauterine growth restriction is an abnormality in the placenta. A placental abnormality can cause intrauterine growth restriction because the fetus may become malnourished. Some other potential causes include: 1  Congenital or chromosomal abnormalities. 2  Heart disease. 3  Diabetes.
Progressive damage caused by the buildup of GM2 ganglioside leads to the destruction of these cells, which causes the signs and symptoms of Tay-Sachs disease. Most of the known HEXA mutations result in a completely nonfunctional version of beta-hexosaminidase A. These mutations cause the severe form of Tay-Sachs disease, which appears in infancy. Other mutations reduce but do not eliminate the activity of beta-hexosaminidase A; these genetic changes are responsible for the less severe forms of Tay-Sachs disease, which appear later in life.