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Sclerodermaâs main types are localized and systemic. Localized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs.3  It may get better or go away without help.4  But it can be severe in some people and can leave skin damage.ocalized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs. 3  It may get better or go away without help. 4  But it can be severe in some people and can leave skin damage.
There are two major forms of scleroderma, localized scleroderma and systemic scleroderma (sclerosis). Diffuse (dcSSc) and limited (lcSSc) scleroderma are the two main types of systemic sclerosis. The more common form of the disease, localized scleroderma, only affects the skin without any internal organ involvement.