In the initial âexpandingâ phase, lymphatic fluid flows at an increased rate and volume from an affected joint to the draining LN via afferent lymphatic vessels. The LN volume expands, presumably to accommodate the influx of cells and lymph exiting the inflamed synovium.
Other signs and symptoms of COPD may include: 1  Shortness of breath, especially during physical activities. 2  Wheezing. 3  Chest tightness.  Having to clear your throat first thing in the morning, due to excess mucus in your 1  lungs. A chronic cough that may produce mucus (sputum) that may be clear, white, yellow or greenish.
In the early stages of COPD, there may be no symptoms, or you may only have mild symptoms, such as: 1  A nagging cough (often called smoker's cough). 2  Shortness of breath, especially with physical activity. 3  Wheezing (a whistling sound when you breathe).4  Tightness in the chest.hronic obstructive pulmonary disease (COPD) is a serious lung disease that gradually makes it harder and harder to breathe. COPD includes emphysema and chronic bronchitis.