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Description of Trazodone. Trazodone: oral antidepressant (trade name Desyrel) that is a nontricyclic drug used as a sedative. Trazodone: A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants.
The Bottom Line: What You Really Need to Know. 1  Trazodone (Trade Names: Deseryl) is an antidepressant with many other uses. 2  The usual dose depends on what it is being taken for and can range from 150-600 mg/day.  Trazodone interacts with many medications.