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Sclerodermaâs main types are localized and systemic. Localized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs.3  It may get better or go away without help.4  But it can be severe in some people and can leave skin damage.ocalized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs. 3  It may get better or go away without help. 4  But it can be severe in some people and can leave skin damage.
Medications. Several types of medications can help ease the signs and symptoms of limited scleroderma, including: 1  Topical antibiotics. 2  If skin ulcers become infected, you may need to apply topical antibiotics and bandage the area.3  If topical treatment doesn't work, you may need oral or intravenous antibiotics. 4  Antacid drugs. If skin ulcers become infected, you may need to apply topical antibiotics and bandage the area. 2  If topical treatment doesn't work, you may need oral or intravenous antibiotics. 3  Antacid drugs. 4  If limited scleroderma is giving you heartburn, your doctor may suggest drugs that reduce the production of stomach acid.