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Sclerodermaâs main types are localized and systemic. Localized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs.3  It may get better or go away without help.4  But it can be severe in some people and can leave skin damage.ocalized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs. 3  It may get better or go away without help. 4  But it can be severe in some people and can leave skin damage.
But if bacteria or inflammation is present with open sores, oral antibiotics or isotretinoin may work better. The most common types of medicines that doctors use to treat acne include: 1  Benzoyl peroxide, such as Brevoxyl or Triaz. 2  Salicylic acid, such as Propa pH or Stridex. 3  Topical and oral antibiotics, such as clindamycin, doxycycline, erythromycin, and tetracycline.