1 negotiate with suppliers from a stronger pre-deal position. 2  no negative surprises in communication to the Market.  KPIâs, budgets and forecasts are adjusted to reflect the changes in overhead and supplier costs.
Scleroderma is a group of diseases that affect connective tissue in the body. This tissue supports your skin and internal organs. Scleroderma involves tissue that gets hard or thick. It can also cause swelling or pain in the muscles and joints.
The exact cause of scleroderma is not known, but it is classified as an autoimmune disease. In an autoimmune disease, the body's immune system mistakes healthy tissues as foreign and potentially dangerous invaders into the body and attacks them.ocalized scleroderma is the milder form of the disease and affects the skin and musculoskeletal system. Systemic scleroderma is generally more serious and can affect connective tissues in many parts of the body, including the lungs, heart digestive tract, blood vessels, and kidneys, as well as the skin.