The beta-blockers with low lipid solubility-i.e. atenolol, nadolol and sotalol-are not metabolised, and their dose must be reduced in renal failure. Propranolol has active metabolites and its dose must also be reduced slightly in uraemia.
Despite the Spanish American War being fought in 1898, many important Spanish American War records still exist. The Spanish American War started in 1898 after an explosion on a U.S. ship in Havana Harbor, the USS Maine, was attributed to Spanish sabotage. Although the Spanish American War lasted only 10 weeks, it resulted in the defeat of the Spanish Empire and gave Americans control of Guam, the Philippines and Puerto Rico.
None. The ship that exploded in Havana Harbor on 15 February 1898 was a US ship named the USS Maine. It had been in port for three weeks in case an evacuation of American civi â¦ lians living there was required. The mysterious explosion which caused the sinking remains of an unidentified origin. America did not blow up the USS Maine.