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When levels fall too low, brain cells cannot generate enough energy to function properly. As a result, Korsakoff syndrome may develop. Korsakoff syndrome is most commonly caused by alcohol misuse, but can also be associated with AIDS, chronic infections, poor nutrition and certain other conditions.
Beriberi generally affects the cardiovascular system (known as wet beriberi) or the nervous system (known as dry beriberi). Wernicke-Korsakoff syndrome is a brain disorder caused by thiamine deficiency that results in a number of neurologic symptoms and can lead to psychosis, confusion and hallucinations.