1 negotiate with suppliers from a stronger pre-deal position. 2  no negative surprises in communication to the Market.  KPIâs, budgets and forecasts are adjusted to reflect the changes in overhead and supplier costs.
Scleroderma is a group of diseases that affect connective tissue in the body. This tissue supports your skin and internal organs. Scleroderma involves tissue that gets hard or thick. It can also cause swelling or pain in the muscles and joints.
Scleroderma occurs when the body produces and accumulates too much collagen in tissues. Collagen is a fibrous type of protein which makes up the body's connective tissues (including skin). Experts suspect that the body's immune system plays a role in the abnormal production of collagen.