The beta-blockers with low lipid solubility-i.e. atenolol, nadolol and sotalol-are not metabolised, and their dose must be reduced in renal failure. Propranolol has active metabolites and its dose must also be reduced slightly in uraemia.
Despite the Spanish American War being fought in 1898, many important Spanish American War records still exist. The Spanish American War started in 1898 after an explosion on a U.S. ship in Havana Harbor, the USS Maine, was attributed to Spanish sabotage. Although the Spanish American War lasted only 10 weeks, it resulted in the defeat of the Spanish Empire and gave Americans control of Guam, the Philippines and Puerto Rico.
Destruction of the Maine. Written By: Destruction of the Maine, (Feb. 15, 1898), an incident preceding the Spanish-American War in which a mysterious explosion sank the U.S. battleship Maine in the harbour of Havana. The destruction of the Maine was one of a series of incidents that precipitated the United Statesâ intervention in the Cuban struggle for independence from Spain, which had begun in 1895. In January 1898, partly as a conciliatory gesture to the Spanish authorities there and partly to protect the lives and property of U.S. citizens presumably endangered by recent riots, the Maine was sent to Havana harbour. On February 15 an explosion sank the ship, carrying 260 seamen to their deaths.