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The small intestine is where most chemical digestion takes place. Many of the digestive enzymes that act in the small intestine are secreted by the pancreas and enter the small intestine via the pancreatic duct.he small intestine is where most chemical digestion takes place. Many of the digestive enzymes that act in the small intestine are secreted by the pancreas and enter the small intestine via the pancreatic duct.
Most chemical digestion occurs in the duodenum, which is part of the small intestine. Chemical digestion also occurs to a lesser degree in the mouth and stomach. No chemic â¦ al digestion occurs in the esophagus or large intestine.