1 negotiate with suppliers from a stronger pre-deal position. 2  no negative surprises in communication to the Market.  KPIâs, budgets and forecasts are adjusted to reflect the changes in overhead and supplier costs.
Scleroderma is a group of diseases that affect connective tissue in the body. This tissue supports your skin and internal organs. Scleroderma involves tissue that gets hard or thick. It can also cause swelling or pain in the muscles and joints.
These findings suggest a hereditary (genetic) component to scleroderma and other autoimmune disorders. Environmental factors could also put people at risk for scleroderma. For example, men exposed to silica appear to have a higher risk for developing scleroderma and certain drugs are capable of causing a scleroderma-like reaction. EARLY SYMPTOMS