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When levels fall too low, brain cells cannot generate enough energy to function properly. As a result, Korsakoff syndrome may develop. Korsakoff syndrome is most commonly caused by alcohol misuse, but can also be associated with AIDS, chronic infections, poor nutrition and certain other conditions.
Korsakoff's syndrome. a mental disorder associated with chronic alcoholism and caused by vitamin B 1 (thiamine) deficiency; it is the amnestic component of the wernicke-korsakoff syndrome.