Call your doctor at once if you have a serious side effect such as: 1  headache with chest pain and severe dizziness, fast or pounding heartbeats, shortness of breath, fainting; 2  diarrhea that is watery or bloody;  fever, swollen glands, body aches, flu symptoms, new or worsening cough;
The maximum daily doses is also slightly different as both Wellbutrin XL and Wellbutrin have a maximum daily dose of 450 mg per day, whereas the maximum dosage for Wellbutrin SR is only 400 mg per day.
Effectiveness - Both Wellbutrin XL and Wellbutrin SR are preparations of the same antidepressant medication bupropion and are equally effective. Absorption - Absorption of the XL formulation is prolonged compared with the SR formulations - T (max) is approximately 5 hours vs approximately approximately 3 hours.