1 negotiate with suppliers from a stronger pre-deal position. 2  no negative surprises in communication to the Market.  KPIâs, budgets and forecasts are adjusted to reflect the changes in overhead and supplier costs.
Scleroderma is a group of diseases that affect connective tissue in the body. This tissue supports your skin and internal organs. Scleroderma involves tissue that gets hard or thick. It can also cause swelling or pain in the muscles and joints.
The two main types of scleroderma are: 1  Localized scleroderma, which usually affects only the skin, although it can spread to the muscles, joints and bones. 2  Systemic scleroderma, which is the most serious form of the disease, affects the skin, muscles, joints, blood vessels, lungs, kidneys, heart and other organs.he cause of scleroderma is not known. Genetic factors (different genes) appear be important in the disease. Although exposure to certain chemicals may play a role in some people having scleroderma, the vast majority of patients with scleroderma do not have a history of exposure to any suspicious toxins.