The beta-blockers with low lipid solubility-i.e. atenolol, nadolol and sotalol-are not metabolised, and their dose must be reduced in renal failure. Propranolol has active metabolites and its dose must also be reduced slightly in uraemia.
Despite the Spanish American War being fought in 1898, many important Spanish American War records still exist. The Spanish American War started in 1898 after an explosion on a U.S. ship in Havana Harbor, the USS Maine, was attributed to Spanish sabotage. Although the Spanish American War lasted only 10 weeks, it resulted in the defeat of the Spanish Empire and gave Americans control of Guam, the Philippines and Puerto Rico.
Introduction. The Battleship Maine. Photographic History of the Spanish American War, p. 36. On April 25, 1898 the United States declared war on Spain following the sinking of the Battleship Maine in Havana harbor on February 15, 1898.The war ended with the signing of the Treaty of Paris on December 10, 1898.he War. Following its declaration of war against Spain issued on April 25, 1898, the United States added the Teller Amendment asserting that it would not attempt to exercise hegemony over Cuba. Two days later Commodore George Dewey sailed from Hong Kong with Emilio Aguinaldo on board.