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Anonymous 31 Aug 2009. It's suppossed to start working about 30 minutes after taking it, but for me it sometimes takes up to an hour. I recently came upon a dual release form of melatonin, where half releases in about 30 minutes, and the the other half is a slow continous release over the night.
Melatonin takes effect in the dogâs body within 10 to 15 minutes. It works within the body for 8 hours and is safe to use, for as long as is necessary. It may be given on a regular basis or when the dog starts to exhibit signs of fear and panic. Melatonin helps regulate the sleeping pattern (circadian rhythm) of dogs. However it doesnât induce drowsiness.