On May 5, 2014, it was announced John Krasinski would direct the film, with Krasinski, Anna Kendrick, Margo Martindale and Richard Jenkins joining the cast.
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus spread by human contact with no know environmental reservoir. Antibodies are detected in 90 to 95% of adults worldwide. EBV infection is subclinical in 90% of children.
To determine whether acute signs and symptoms are due to HBV infection; two tests, hepatitis B surface Ag and hepatitis B core antibody IgM, may be performed as part of an acute viral hepatitis panel along with tests for hepatitis A (HAV) and hepatitis C (HCV) to determine which virus may be causing the infection.