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A chromosome mutation is an unpredictable change that occurs in a chromosome. These changes are most often brought on by problems that occur during meiosis (cell division process of gametes) or by mutagens (chemicals, radiation, etc.). chromosome mutation that results in individuals with more than one haploid set of chromosomes in a cell is termed polyploidy. A haploid cell is a cell that contains one complete set of chromosomes.
â¢ Gene mutation is a change in the nucleotide sequence, in a particular gene, whereas chromosomal mutation is a change in several genes, in the chromosome.ene Mutation. Gene mutation is a small-scale alteration of the genetic material of an organism, which primarily is a change in the nucleotide sequence of a particular gene. These changes are of two types based on the way those take place.