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Respiratory acidosis occurs when the arterial partial pressure of carbon dioxide (Pa CO2) is elevated above the normal range (>44 mm Hg) leading to a blood pH lower than 7.35.By definition, the diagnosis of respiratory acidosis requires measurement of Pa CO2 and pH. When the diagnosis is made, the underlying cause should be thoroughly investigated.
Lactic acidosis can occur in acute severe asthma due to inadequate oxygen delivery to the respiratory muscles to meet an elevated oxygen demand3 or due to fatiguing respiratory muscles4 . A less recognised cause of lactic acidosis is treatment with salbutamol. The mechanism of this complication is poorly understood. Salbutamol is the most commonly used short acting Î²agonist.