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Colon, or colorectal, cancer is cancer that starts in the large intestine (colon) or the rectum (end of the colon). Other types of cancer can affect the colon. These include lymphoma, carcinoid tumors, melanoma, and sarcomas. These are rare. In this article, colon cancer refers to colon carcinoma only.
1 The colon is the lowest section of the digestive system. 2  Colon cancer and rectal cancer often occur together and are called colorectal cancer. 3  There will be an estimated 95,270 new cases of colon cancer in the United States in 2016.  Colon cancer is the third most common cause of cancer death in the U.S.