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When levels fall too low, brain cells cannot generate enough energy to function properly. As a result, Korsakoff syndrome may develop. Korsakoff syndrome is most commonly caused by alcohol misuse, but can also be associated with AIDS, chronic infections, poor nutrition and certain other conditions.
Alcohol is linked to the development of Wernicke-Korsakoff syndrome, a brain disorder resulting from thiamine (vitamin B1) deficiency. Wernicke-Korsakoff syndrome is actually a two-stage brain disorder in which Karsakoff syndrome (also known as Korsakoff psychosis) develops due to permanent brain damage as symptoms of Wernicke encephalopathy wane.