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When levels fall too low, brain cells cannot generate enough energy to function properly. As a result, Korsakoff syndrome may develop. Korsakoff syndrome is most commonly caused by alcohol misuse, but can also be associated with AIDS, chronic infections, poor nutrition and certain other conditions.
CORTICAL ATROPHY IN ALZHEIMERâS. The atrophy of the cortex that is seen in Alzheimerâs-type dementia depends on the amount of neurofibrillary degeneration and build-up of amyloid plaques in the brain. The extent of this atrophy generally correlates with the extent of the cognitive losses observed.he atrophy of the cortex that is seen in Alzheimerâs-type dementia depends on the amount of neurofibrillary degeneration and build-up of amyloid plaques in the brain. The extent of this atrophy generally correlates with the extent of the cognitive losses observed.