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The small intestine is where most chemical digestion takes place. Many of the digestive enzymes that act in the small intestine are secreted by the pancreas and enter the small intestine via the pancreatic duct.he small intestine is where most chemical digestion takes place. Many of the digestive enzymes that act in the small intestine are secreted by the pancreas and enter the small intestine via the pancreatic duct.
Mouth. Chemical digestion first begins in the mouth where the food arrives and encounters saliva. In the oral cavity, salivary glands secrete the saliva with a multitude of enzymes and substances in order to assist in the digestion and disinfection of the food.