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Nongated ion channels establish the resting membranepotential of neurons; voltage-gated ion channels are re-sponsible for the action potential and the release of neuro-transmitter.2. Ligand-gated ion channels cause membrane depolariza-tion or hyperpolarization in response to neurotransmit-ter.3.
Therefore, it takes about 3-4 ms for all Na+ channels to come out of inactivation in order to be ready for activation (opening) again. The period from the initiation of the action potential to immediately after the peak is referred to as the absolute refractory period (ARP) (see Figs. 1 and 2). This is the time during which another stimulus given to the neuron (no matter how strong) will not lead to a second action potential.