N2 nicotinic receptors are found in the brain, plus the autonomic and parasympathetic nervous systems [1]. Different subunits make up these two types of nicotinic receptor, which is why we consider them separately. Muscarinic receptors have a different mechanism of action.
Your body weight can regularly fluctuate, but the persistent, unintentional loss of more than 5% of your weight over 6 to 12 months is usually a cause for concern. You should pay particular attention if you experience other symptoms, such as tiredness, loss of appetite and a change in your toilet habits.
Insulin and sulfonylureas, a type of diabetes pill (brands include Glyburide and Glipizide), can cause a person to gain some weight, usually 10 to 15 pounds over one to two years. This is because these medications help the body use all the sugar that comes from the food a person eats.