The beta-blockers with low lipid solubility-i.e. atenolol, nadolol and sotalol-are not metabolised, and their dose must be reduced in renal failure. Propranolol has active metabolites and its dose must also be reduced slightly in uraemia.
Despite the Spanish American War being fought in 1898, many important Spanish American War records still exist. The Spanish American War started in 1898 after an explosion on a U.S. ship in Havana Harbor, the USS Maine, was attributed to Spanish sabotage. Although the Spanish American War lasted only 10 weeks, it resulted in the defeat of the Spanish Empire and gave Americans control of Guam, the Philippines and Puerto Rico.
In April 1898 Congress declared war on Spain, and the Spanish-American War began. The four-month war ended in August with a victory for the United States. The first action occurred thousands of miles away from Cuba in the Philippines, another Spanish colony. well-publicized incident drew the United States into the conflict. On February 15, 1898, an American battleship, the Maine, exploded in Havana harbor, killing 266 people. Most Americans blamed the Spanish, and Remember the Maine became a call to arms. McKinley began negotiations with Spain for a settlement with Cuba.