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NSAIDs (nonsteroidal anti-inflammatory drugs) NSAIDs (nonsteroidal anti-inflammatory drugs) are some of the most commonly used pain medicines in adults. They are also a common treatment for chronic (long-term) health problems, such as arthritis (rheumatoid arthritis, osteoarthritis, and others) and lupus. NSAIDs block proteins, called enzymes, in the body that help make prostaglandins.
NSAIDs Overview. Nonsteroidal anti-inflammatory drugs reduce the inflammation that accompanies arthritis. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to relieve pain and inflammation from arthritis and related conditions. They work by blocking hormone-like substances called prostaglandins, which are involved in pain and inflammation.