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Hyperparathyroidism is a condition in which the parathyroid glands secrete too much parathyroid hormone. This results in abnormal blood calcium levels and can cause weakness, fatigue, depression, muscle aches, constipation, lack of appetite and nausea.
Kidney, liver and heart disease can also reduce the appetite. In some cases, sudden loss of appetite occurs at an advanced stage illness, such as congestive heart failure or kidney failure. Psychological diseases including depression, anxiety disorder and schizophrenia can also cause sudden loss of appetite, particularly if symptoms of the underlying disease increase suddenly.