Sulfonylureas stimulate the beta cells of the pancreas to release more insulin. Sulfonylurea drugs have been in use since the 1950s. Chlorpropamide (Diabinese) is the only first-generation sulfonylurea still in use today. The second generation sulfonylureas are used in smaller doses than the first-generation drugs.
Robert Woofendale was one of the first men to practice dentistry full time in the States â for most it was a side profession intended to bring in a little money here and there. John Baker was a dentist in Boston who, based on entries from George Washingtonâs ledger book, did some dental work for the first president.
James Pierson Beckwourth, born James Beckwith and generally known as, Jim Beckwourth (April 26, 1798 or 1800 â October 29, 1866 or 1867) was an American mountain man, fur trader, and explorer. A mulatto born into slavery in Virginia, he was freed by his father (and master) and apprenticed to a blacksmith; later he moved to the American West.