N2 nicotinic receptors are found in the brain, plus the autonomic and parasympathetic nervous systems [1]. Different subunits make up these two types of nicotinic receptor, which is why we consider them separately. Muscarinic receptors have a different mechanism of action.
Your body weight can regularly fluctuate, but the persistent, unintentional loss of more than 5% of your weight over 6 to 12 months is usually a cause for concern. You should pay particular attention if you experience other symptoms, such as tiredness, loss of appetite and a change in your toilet habits.
Depending on what caused the weight loss, symptoms vary widely. You may notice a change in the way your clothes fit, or in the shape of your face, since that is an area where many people can see initial weight loss effects. However, some people are unaware that theyâve lost weight until they weigh themselves.