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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Treatment with metformin can cause a serious condition called lactic acidosis (the accumulation of too much acid in the blood), which requires urgent hospital treatment. Its symptoms include muscle cramps, abdominal pain, breathlessness and a feeling of being very weak and unwell.