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A chromosome mutation is an unpredictable change that occurs in a chromosome. These changes are most often brought on by problems that occur during meiosis (cell division process of gametes) or by mutagens (chemicals, radiation, etc.). chromosome mutation that results in individuals with more than one haploid set of chromosomes in a cell is termed polyploidy. A haploid cell is a cell that contains one complete set of chromosomes.
Gene mutation is basically the change in the nucleotide sequence while chromosome mutation is the change in several genes. These gene mutations are basically small changes in the gene while chromosome mutation is the alteration that happens on a large scale.. Gene mutation. Gene mutation is considered as the small scale change in a nucleotide sequence. The altering of the genetic material on an organism happens in two ways. Point mutations and frame shift mutations are two bases which play a vital role whenever any change happens in a nucleotide sequence.