On May 5, 2014, it was announced John Krasinski would direct the film, with Krasinski, Anna Kendrick, Margo Martindale and Richard Jenkins joining the cast.
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus spread by human contact with no know environmental reservoir. Antibodies are detected in 90 to 95% of adults worldwide. EBV infection is subclinical in 90% of children.
The Epstein-Barr virus (EBV) is a member of the herpes virus family (human herpesvirus 4). EBV is found worldwide and is a common cause of viral pharyngitis, especially in young adults. EBV is transmitted from person to person and then infects human B cells, which in turn spread the infection throughout the entire reticuloendothelial system (RES, or the liver, spleen, and peripheral lymph nodes).