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What happens here is that your cells run out of oxygen, you run out of energy, and your muscles feel sore due to the lactic acid dumped into the muscle tissues by your cells. What the body's cells are pretty convincingly trying to tell you here is- stop exercising or we will die.
This links to blood, oxygen and muscles because when stroke volume increases the volume of blood increases (when stroke volume increases cardiac output increases), this means that more oxygen can then be delivered to the working muscles so this is how blood, oxygen and muscles link to cardiac output.