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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Some metformin warnings and precautions relate to monitoring your liver function while taking metformin, the possibility of the medication decreasing your B12 levels, and the potential for metformin to cause low blood sugar.