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When levels fall too low, brain cells cannot generate enough energy to function properly. As a result, Korsakoff syndrome may develop. Korsakoff syndrome is most commonly caused by alcohol misuse, but can also be associated with AIDS, chronic infections, poor nutrition and certain other conditions.
Korsakoff syndrome commonly develops after the onset of Wernickeâs encephalopathy; however, people may develop this syndrome independently of it. Unlike the sudden onset of Wernickeâs encephalopathy, Korsakoff syndrome may develop gradually over time.