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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Metformin works in a few ways. It helps your body properly respond to its insulin, reduces glucose production in the liver, and helps block glucose absorption in your intestines. Metformin is a quick-acting oral medicationâyou will typically see some effect within 48 hours of starting the medication.