The beta-blockers with low lipid solubility-i.e. atenolol, nadolol and sotalol-are not metabolised, and their dose must be reduced in renal failure. Propranolol has active metabolites and its dose must also be reduced slightly in uraemia.
Despite the Spanish American War being fought in 1898, many important Spanish American War records still exist. The Spanish American War started in 1898 after an explosion on a U.S. ship in Havana Harbor, the USS Maine, was attributed to Spanish sabotage. Although the Spanish American War lasted only 10 weeks, it resulted in the defeat of the Spanish Empire and gave Americans control of Guam, the Philippines and Puerto Rico.
On February 15th, 1898, over 250 American sailors were killed when the battleship Maine blew up and sank in Havana harbor. The war with Spain began in April, 1898 when Major General William Shafter, a former commander of the 24th Infantry led an expeditionary force of over 17,000 men, including nearly 3,000 Black regulars, into Cuba. (11)