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In addition to an increase level of TSH above 2.5 mU/L during the first trimester, and above 3 mU/L in the second and third trimester, a decrease fT4 concentration (also using reference range for pregnant women) will help clinicians diagnose overt hypothyroidism during pregnancy.
Being pregnant can be a stress test for the thyroid. The size of the gland increases by 10%. Production of thyroid hormones T3 and T4 increases by about 50%. As a result, the normal thyroid-stimulating hormone (TSH) level during pregnancy is lower than the normal nonpregnancy level.irst trimester: less than 2.5 with a range of 0.1-2.5. Second trimester: 0.2-3.0. Third trimester: 0.3-3.0. If the TSH is greater than 2.5 at any time during pregnancy, T4 levels should be checked to determine whether the hypothyroidism is overt or subclinical.