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How long does it take for elevated liver enzymes to return to normal after cessation of alcohol consumption? It takes approximately twenty-four to forty-eight hours for elevated liver enzymes to return to normal after cessation of alcohol consumption. For smaller individuals, it can â¦ take even longer. AlcoholResearcher
ALP should return to normal within 2-8 weeks of the withdrawal of the offending drug or discontinuation of alcohol use. With continued alcohol use, the NP should anticipate that ALP remains persistently elevated but usually does not exceed 3 times ULN. Changes seen in fatty liver should resolve with weight loss.