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If kidneys don't work properly, harmful substances build up in the body, blood pressure can rise, and too much fluid can collect in the body's tissues, which leads to swelling, called edema. If your kidneys fail, you will need dialysis or a kidney transplant to take over their job.
When enough of the glomeruli in the nephrons are destroyed, chronic kidney disease can lead to end stage renal disease (ESRD) or kidney failure. It is at this point that either dialysis or a transplant is needed.hronic kidney disease progresses over many years, but if someone starts to lose kidney function in their teens and it goes undiagnosed, by the time the person is in their thirties or forties, they may progress to end stage renal disease and require dialysis.