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Elephantiasis is caused by obstruction of the lymphatic system, which results in the accumulation of a fluid called lymph in the affected areas. Functioning as part of the immune system, the lymphatic system helps to protect the body against infection and disease.
Some of the common causes of Charlieâs Horses in legs are: 1  Mineral deficiency: Low levels of mineral such as potassium and calcium may lead to cramping. 2  Low levels of body fluids while doing strenuous exercise may lead to Charlie Horses. 3  Hormonal imbalance is also a cause for Charlie Horses.