N2 nicotinic receptors are found in the brain, plus the autonomic and parasympathetic nervous systems [1]. Different subunits make up these two types of nicotinic receptor, which is why we consider them separately. Muscarinic receptors have a different mechanism of action.
Your body weight can regularly fluctuate, but the persistent, unintentional loss of more than 5% of your weight over 6 to 12 months is usually a cause for concern. You should pay particular attention if you experience other symptoms, such as tiredness, loss of appetite and a change in your toilet habits.
For example: 1  Overeating or inactivity as a result of depression can cause weight gain. 2  Some people lose weight as part of their depression. In turn, an improved appetite associated with improved mood may result in increased weight. 3  Adults generally tend to gain weight as they age, regardless of the medications they take.