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If kidneys don't work properly, harmful substances build up in the body, blood pressure can rise, and too much fluid can collect in the body's tissues, which leads to swelling, called edema. If your kidneys fail, you will need dialysis or a kidney transplant to take over their job.
When it causes severe kidney failure (when kidney function is less than 10 percent of normal), dialysis may be needed to do the work of the kidneys. Different forms of dialysis may be used depending on each individual's needs. Most HUS patients that require dialysis ultimately recover their kidney function.