The beta-blockers with low lipid solubility-i.e. atenolol, nadolol and sotalol-are not metabolised, and their dose must be reduced in renal failure. Propranolol has active metabolites and its dose must also be reduced slightly in uraemia.
Despite the Spanish American War being fought in 1898, many important Spanish American War records still exist. The Spanish American War started in 1898 after an explosion on a U.S. ship in Havana Harbor, the USS Maine, was attributed to Spanish sabotage. Although the Spanish American War lasted only 10 weeks, it resulted in the defeat of the Spanish Empire and gave Americans control of Guam, the Philippines and Puerto Rico.
Best Answer: The Spanish-American War was a conflict between the Kingdom of Spain and the United States of America that took place from April to August 1898. It was caused by American demands that Spain resolve peacefully the insurrection in Cuba, which Spain was unable to do. The explosion of the American battleship Maine raised tensions but was not the main cause of the war, nor was yellow journalism in New York City that harped on Spanish atrocities.