In situations where the concomitant use of clarithromycin with statins cannot be avoided, it is recommended to prescribe the lowest registered dose of the statin. Use of a statin that is not dependent on CYP3A metabolism (e.g. fluvastatin or pravastatin) should be considered (see section 4.5).
On the basis of these data, they assumed the ancient model of and estimated both a recent epoch of exponential growth and the population size before growth, pointing to growth starting 3.5 (2.9â4.1) kya at a rate of 3.4% (2.4â5.1%) per generation, resulting at 0.65 (0.30â2.87) millions individuals today (Figure 1b and Table 2).
The BSP for six Russian populations demonstrates an increase of human population size up to around 50 kya (95% CI: 46â61 kya) followed by a prolonged period of slow decrease up to 24.5 kya (95% CI: 21.7-26.1 kya) in the Last Glacial Maximum (LGM), and then an expansion up to 13-11 kya .