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The hypothalamus releases thyrotropin releasing hormone (TrH), which travels via a venous plexus to the anterior lobe of the pituitary gland and stimulates release of thyroid stimulating hormone (TSH). TSH then induces production of thyroxine (T4) by the thyroid.ased on the functional interrelationship of the hypothalamus, pituitary gland, and thyroid, TSH should be elevated if the thyroid gland is not producing adequate thyroid hormone, and suppressed if it is producing too much (Figure 1).
Thyroid stimulating hormone: A hormone produced by the pituitary gland at the base of the brain in response to signals from the hypothalamus gland in the brain.Thyroid stimulating hormone (TSH) promotes the growth of the thyroid gland in the neck and stimulates it to produce more thyroid hormones.When there is an excessive amount of thyroid hormones, the pituitary gland stops producing TSH, reducing thyroid hormone production.This mechanism maintains a relatively constant level of thyroid hormones circulating in the blood.hen there is an excessive amount of thyroid hormones, the pituitary gland stops producing TSH, reducing thyroid hormone production. This mechanism maintains a relatively constant level of thyroid hormones circulating in the blood.