Soccer Positions. According to the rules of soccer, there are only two types of players, the goalkeeper and everyone else. However, in actual play, different players will need to have different skills and play different roles or positions. Below we will discuss some of those roles.
In some lung cancer patients this gene, called EGFR, contains a DNA change known as an inherited EGFR mutation. Early data indicate that these inherited EGFR mutations may be associated with an increased risk of lung cancer. So far, only a small number of families have been found to carry inherited EGFR mutations. For this reason the risk of lung cancer associated with inherited EGFR mutations is not well understood.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Epidermal growth factor receptor mutation is associated with response to therapy in resected advanced non-small-cell lung cancer. 2  Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer. 3  EGFR activating mutations are associated with brain metastases in non-small lung cancer.