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In genetics, a transcription terminator is a section of nucleic acid sequence that marks the end of a gene or operon in genomic DNA during transcription.
a mutation in which one of the three terminator codons in the mRNA used to signal the end of a polypeptide appears in the middle of a genetic message and causes premature termination of transcription and release of incomplete, generally nonfunctional polypeptides from the ribosome.