PLACE NAMES. The next most common source of Jewish last names is probably places. Jews used the town or region where they lived, or where their families came from, as their last name. As a result, the Germanic origins of most East European Jews is reflected in their names.
For other uses, see Malignancy (disambiguation). Malignancy (from Latin male, meaning 'badly', and -gnus, meaning 'born') is the tendency of a medical condition to become progressively worse. Malignancy is most familiar as a characterization of cancer.
Malignancy in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by genome instability, so that cancers, as assessed by whole genome sequencing, frequently have between 10,000 and 100,000 mutations in their entire genomes.