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In genetics, a transcription terminator is a section of nucleic acid sequence that marks the end of a gene or operon in genomic DNA during transcription.
Transcription termination of protein-coding genes requires recognition of the polyadenylation signal. This provides a signal for binding many factors involved in 3â²-end formation, which in turn renders RNAPII competent for termination (Whitelaw and Proudfoot 1986; Logan et al.