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Description. This medicine, Trazodone (Desyrel), is a modified cyclic antidepressant. Trazodone belongs to the group of medicines known as antidepressants or mood elevators.. It is used to treat mental depression and depression that sometimes occurs with anxiety.
Prazosin is an alpha-adrenergic blocker originally used to treat hypertension. The reason we think it works in the setting of nightmares is that prazosin crosses the bloodâbrain barrier, so it gets into the brain and kind of dampens the norepinephrine effects, which we think contribute to nightmares, he said.