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Hematopoietic stem cell transplantation (HSCT) exposes the kidney to a multitude of injuries, including acute kidney injury (AKI), hypertension, glomerular disease, and chronic kidney disease (CKD).A common pathology noted in most of these patients is a renal-limited thrombotic microangiopathy (TMA).A-TMA happens typically six months to one year after patient receive a HSCT. While CNI-TMA is an idiosyncratic reaction, TA-TMA is the result of many other factors. Lactate dehydrogenase levels are in much higher range in TA-TMA compared to CNI-TMA.
P-TMA is considered a secondary form of TMA. It accounts for 8%â18% of all cases of TMA (24, 26, 40, 41). In the French aHUS registry, one of five women presented with aHUS at the time of pregnancy (24).ther causes include postabortum (first trimester) or puerperal sepsis, ante-or postpartum hemorrhage, intrauterine death, acute fatty liver, and thrombotic microangiopathy (TMA). The main causes of P-AKI are shown in Figure 1 according to their predominant timing of occurrence during pregnancy.