Several other disease processes involve both inflammation and bone uncoupling. For example, similar to periodontal disease, osteoporosis is also characterized by uncoupling due to deficient bone formation following bone resorption. list of molecules that could mediate the effects of inflammation on uncoupling is provided in Table 2. Although this review focuses on bone, it is recognized that, for periodontal regeneration to occur, the formation of new cementum and periodontal ligament must also take place (Foster et al., 2007).
Lenneberg (1967) sees the critical period starting at the age of 2 and ending around puberty, a period, which coincides with the brain lateralisation process, which is the specialisation of the dominant hemisphere of the brain language functions. Lenneberg (1967) cited a wide evidence of changes in the brain taking place during this period.
Theorists disagree about how important it is for children to have that special stimuli at each growing stage in order to reach their milestones. Some theorists call these times critical periods, but other theorists call them sensitive periods. The difference between critical periods and sensitive periods is subtle. Theorists who believe in critical periods believe that children who do not get special stimulation during their window of receptivity are going to be stuck forever and never gain the abilities they should have gained in that period.