In situations where the concomitant use of clarithromycin with statins cannot be avoided, it is recommended to prescribe the lowest registered dose of the statin. Use of a statin that is not dependent on CYP3A metabolism (e.g. fluvastatin or pravastatin) should be considered (see section 4.5).
On the basis of these data, they assumed the ancient model of and estimated both a recent epoch of exponential growth and the population size before growth, pointing to growth starting 3.5 (2.9â4.1) kya at a rate of 3.4% (2.4â5.1%) per generation, resulting at 0.65 (0.30â2.87) millions individuals today (Figure 1b and Table 2).
Kentucky population density by census tract (2010), showing the concentration of settlement around Jefferson, Fayette, and Kenton counties. Since January 1, 2015, Kentucky cities have been divided into two classes based on their form of government: This system went into effect on January 1, 2015, following the 2014 passage of House Bill 331 by the Kentucky General Assembly and the bill's signing into law by Governor Steve Beshear. The new system replaced one in which cities were divided into six classes based on their population at the time of their classification.