DST isoform 6 is required for bundling actin filaments around the nucleus. DST isoform 7 regulates the organisation and stability of the microtubule network of sensory neurons to allow axonal transport. Molecular pathology. Defects of DST cause hereditary sensory and autonomic neuropathy type 6.
Long Time Survivor. Not only does the virus survive in adverse climate conditions, it's also quite long living. According to Utah Veterinary Clinics, parvo can live in the environment for six months to one year. The time frame seems to depend on several factors.
Some puppies clear the maternal antibodies at 7 weeks, others take as long as 15 weeks. Some puppies (rarely) have no maternal antibodies to parvo. By vaccinating at 6, 9, 12 and (possibly) 15 weeks, you increase the likelihood that your dog is able to mount a protective immune response to the vaccine. The same is basically true about distemper, which is why the vaccines are always given together.