Causes of Ankle Pain. 1  Ankylosing Spondylitis Ankylosing spondylitis is a type of arthritis that causes chronic inflammation of the spine. 2  Arthritis Arthritis is inflammation of one or more joints. 3  Broken Bone (Types of Bone Fractures) A broken bone is a fracture.
Down syndrome is a chromosomal condition that is associated with intellectual disability, a characteristic facial appearance, and weak muscle tone (hypotonia) in infancy. All affected individuals experience cognitive delays, but the intellectual disability is usually mild to moderate.
Down syndrome, also known as trisomy 21, is a chromosomal mutation in the form of a third duplicate of a human's 21st chromosome.