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(east side of 5th Ave. between 50th & 51st Streets). St. Patrickâs Cathedral is the see of the Catholic Archdiocese of New York, and symbolized the rise of the Catholic community in the city as it moved uptown from more humble origins on Mulberry Street.
Confidence votes 25. St Patrick's Cathedral in New York City. ***Actually, the Basilica of the National Shrine of the Immaculate Conception in DC is larger than St. Patrick's in NYC. The National Shrine is the largest Roman Catholic church in the U.S., and one of the 10 largest Roman Catholic churches in the world.