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Use gastrula in a sentence. pl. -Â·laeÂ· or -Â·las. an embryo in an early stage of development, consisting of a sac with two layers, the ectoderm and endoderm, enclosing a central cavity, the archenteron, that opens to the outside through the blastopore. Origin of gastrula.
(gas'trÅ«-lÄ'shÅ­n), 1  Transformation of the blastula or blastocyst into the gastrula; the development and invagination of the embryonic germ layers. In human embryos, gastrulation is the process by which the bilaminar embryonic disk is converted into a trilaminar embryonic disk.