SÅAWOMIRA f Polish. Polish feminine form of SÅAWOMIR. SLOAN f English (Rare). Variant of SLOANE. SLOANE f English (Rare). From an Irish surname which was derived from an Anglicized form of the given name SLUAGHADHAN. SLUAGHADHÃ¡N slobodan M, Serbian, Macedonian. Croatian From South slavic sloboda meaning. freedomreek form of SOPHRONIUS. SOPHRONIUS m Late Greek (Latinized). Latinized form of the Greek name ÏÏÏÏÎ¿Î½Î¹Î¿Ï (Sophronios) , which was derived from Greek ÏÏÏÏÏÎ½ (sophron) self-controlled, sensible ... [more]. SOPHUS m Ancient Greek (Latinized). From the Greek name ÏÎ¿ÏÎ¿Ï (Sophos) which meant skilled, clever.
But a burgeoning field known as epigenetics is showing that many cancers may not be caused by mutations in genes, but by chemical modifications that alter how the genes function. Such modifications to genes are epigenetic-literally on top of or related to changes in the DNA sequence.
Cancer initiation and progression are accompanied by profound changes in DNA methylation that were the first epigenetic alterations identified in cancer (67, 68). A cancer epigenome is marked by genome-wide hypomethylation and site-specific CpG island promoter hypermethylation (Figure 2) (3).bstract. Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Global changes in the epigenetic landscape are a hallmark of cancer.