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Non-invasive procedure. A medical procedure is defined as non-invasive when no break in the skin is created and there is no contact with the mucosa, or skin break, or internal body cavity beyond a natural or artificial body orifice. For example, deep palpation and percussion are non-invasive but a rectal examination is invasive.
The injection of substances directly into the body requires strict asepsis to avoid complications. Injected substances and the needles/syringes used to inject substances must be sterile. Potential complications for all routes of injection include infection, local irritation, pain and damage to surrounding tissue.