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tolerance. Tolerance is the quality of requiring a larger dose of a certain drug every time to reach the same effects. For example, if you need 2-5 hits to get stoned at first, if you smoke regularly and at close intervals (every day or every other day) you will start requiring more hits to get the same high.
1 Tolerance, as defined by either of the following: 2  A need for markedly increased amounts of the substance to achieve intoxication or desired effect.  A markedly diminished effect with continued use of the same amount of the substance.