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The hypothalamus releases thyrotropin releasing hormone (TrH), which travels via a venous plexus to the anterior lobe of the pituitary gland and stimulates release of thyroid stimulating hormone (TSH). TSH then induces production of thyroxine (T4) by the thyroid.ased on the functional interrelationship of the hypothalamus, pituitary gland, and thyroid, TSH should be elevated if the thyroid gland is not producing adequate thyroid hormone, and suppressed if it is producing too much (Figure 1).
The pituitary gland and the thyroid gland work together. The pituitary gland (located near the base of the brain) makes, stores, and releases thyroid-stimulating hormone (TSH). When TSH is secreted by the pituitary gland, it causes the thyroid gland to release more T3 and T4.hyroid hormones are made by the thyroid gland. The thyroid gland makes and releases two thyroid hormones: thyroxine (T4) and triiodothyronine (T3). Thyroid hormones affect every cell and all the organs of the body. Too much thyroid hormone speeds things up and too little thyroid hormone slows things down.