Several other disease processes involve both inflammation and bone uncoupling. For example, similar to periodontal disease, osteoporosis is also characterized by uncoupling due to deficient bone formation following bone resorption. list of molecules that could mediate the effects of inflammation on uncoupling is provided in Table 2. Although this review focuses on bone, it is recognized that, for periodontal regeneration to occur, the formation of new cementum and periodontal ligament must also take place (Foster et al., 2007).
Lenneberg (1967) sees the critical period starting at the age of 2 and ending around puberty, a period, which coincides with the brain lateralisation process, which is the specialisation of the dominant hemisphere of the brain language functions. Lenneberg (1967) cited a wide evidence of changes in the brain taking place during this period.
However, it's also important to remember that critical or sensitive periods can also affect children in other ways than just neglect or deprivation. For example, there is a critical or sensitive period for language acquisition that occurs during infancy. Children begin learning how to understand and create language from the time they're born. They will absorb and copy the language they hear all around them during that critical or sensitive period early in life. However, for many different reasons, children, and adults, may leave their original home and move to a new country or region where people speak a different language.