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Hematopoietic stem cell transplantation (HSCT) exposes the kidney to a multitude of injuries, including acute kidney injury (AKI), hypertension, glomerular disease, and chronic kidney disease (CKD).A common pathology noted in most of these patients is a renal-limited thrombotic microangiopathy (TMA).A-TMA happens typically six months to one year after patient receive a HSCT. While CNI-TMA is an idiosyncratic reaction, TA-TMA is the result of many other factors. Lactate dehydrogenase levels are in much higher range in TA-TMA compared to CNI-TMA.
Background. The extremely thin and delicate tympanic membrane (TM) is the first component of the middle ear conductive system. The TM is easily traumatized, and diseases of the TM deprive patients of their ability to work and to enjoy life. With the appearance of fluid in the middle ear, these phenomena disappear from the surface of the TM, so observing the fluid is possible. 2  The inflammatory process of an upper respiratory tract infection affects the TM in the form of myringitis. 3  The TM becomes red and thickened, and the light reflex disappears.