My feet & ankles are swollen, hot and reddish color. I have high blood pressure, lupus, asthma, back problems, diabetic, fibromyalgia, and Padgett disease, an enlarged heart, and enlarged thymus gland.
1 Free T4 (Free Thyroxine) â considered a precursor hormone, T4 is converted to T3 as required by cells throughout the body; levels of T4 are generally much higher than T3.  Total T4 (Total Thyroxine) - Most T4 in the blood is bound to carrier proteins which make it biologically inactive. Total T4 includes unbound (free) T4 plus T4 that is bound to carrier proteins in the blood.
Summary. Inherited thyroxine-binding globulin deficiency is a genetic condition that typically does not cause any health problems. Thyroxine-binding globulin is a protein that carries hormones made or used by the thyroid gland, which is a butterfly-shaped tissue in the lower neck.Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).hyroxine-binding globulin is a protein that carries hormones made or used by the thyroid gland, which is a butterfly-shaped tissue in the lower neck.