In situations where the concomitant use of clarithromycin with statins cannot be avoided, it is recommended to prescribe the lowest registered dose of the statin. Use of a statin that is not dependent on CYP3A metabolism (e.g. fluvastatin or pravastatin) should be considered (see section 4.5).
On the basis of these data, they assumed the ancient model of and estimated both a recent epoch of exponential growth and the population size before growth, pointing to growth starting 3.5 (2.9â4.1) kya at a rate of 3.4% (2.4â5.1%) per generation, resulting at 0.65 (0.30â2.87) millions individuals today (Figure 1b and Table 2).
As of the 2000 census, the MSA had a population of 107,547 (though a July 1, 2009 estimate placed the population at 113,433). The ElizabethtownâFort Knox Metropolitan Statistical Area is part of the LouisvilleâElizabethtownâMadison, KY-IN Combined Statistical Area, which covers a 17-county area (eleven in Kentucky and six in Indiana). The Census Bureau officially changed the name of the metropolitan area from Elizabethtown to ElizabethtownâFort Knox in 2013.