In situations where the concomitant use of clarithromycin with statins cannot be avoided, it is recommended to prescribe the lowest registered dose of the statin. Use of a statin that is not dependent on CYP3A metabolism (e.g. fluvastatin or pravastatin) should be considered (see section 4.5).
On the basis of these data, they assumed the ancient model of and estimated both a recent epoch of exponential growth and the population size before growth, pointing to growth starting 3.5 (2.9â4.1) kya at a rate of 3.4% (2.4â5.1%) per generation, resulting at 0.65 (0.30â2.87) millions individuals today (Figure 1b and Table 2).
Kentucky Zip Code Listings 2016 At 40,409 square miles, Kentucky is the 37th largest state in America. Administratively, Kentucky is divided into 4,650 cities and towns and 120 counties. The state's population in 2013 is 4,395,296, according to the 2013 United States Census, making it the 26th most populous state in America.