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Hematopoietic stem cell transplantation (HSCT) exposes the kidney to a multitude of injuries, including acute kidney injury (AKI), hypertension, glomerular disease, and chronic kidney disease (CKD).A common pathology noted in most of these patients is a renal-limited thrombotic microangiopathy (TMA).A-TMA happens typically six months to one year after patient receive a HSCT. While CNI-TMA is an idiosyncratic reaction, TA-TMA is the result of many other factors. Lactate dehydrogenase levels are in much higher range in TA-TMA compared to CNI-TMA.
It must exist in association with a counter-ion, and is most commonly found in simple salts such as tetramethylammonium chloride, tetramethylammonium bromide, tetramethylammonium iodide and tetramethylammonium hydroxide.rom measurements taken on molecular models, it has been estimated that the diameter of the TMA ion is ~ 0.6 nm; In more recent studies, based on more accurate physico-chemical measurements, the ionic radius for TMA is given as 0.322 nm; several thermodynamic parameters for the TMA ion are also recorded.