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Better Sleep. Perhaps one of the most common benefits of melatonin is its use to promote healthy sleep patterns. People who suffer from insomnia due to work, travel or stress can take melatonin supplements to induce and sustain lasting sleep and promote healthy sleeping patterns over the long term, according to Life Extension Magazine online.
Melatonin is also used for some of the side effects of cancer treatment (chemotherapy) including weight loss, nerve pain, weakness, and a lowered number of clot-forming cells (thrombocytopenia). It is also used to calm people before they are given anesthesia for surgery. Sleeping problems in people with sleep-wake cycle disturbances. 2  Taking melatonin by mouth is helpful for disturbed sleep-wake cycles in children and adolescents with intellectual disabilities, autism, and other central nervous system disorders.