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It is differentiated from acute kidney disease in that the reduction in kidney function must be present for over 3 months. Chronic kidney disease is identified by a blood test for creatinine, which is a breakdown product of muscle metabolism. Higher levels of creatinine indicate a lower glomerular filtration rate and as a result a decreased capability of the kidneys to excrete waste products.
Also known as diabetic nephropathy, this condition is a result of direct vascular abnormalities that accompany diabetes. Furthermore, diabetes mellitus is the main cause of end-stage renal disease (ESRD), the most advanced stage of kidney disease.Stages of Chronic Kidney Disease (CKD).These are some of the progressive stages chronic of kidney disease. While there is impaired kidney function, during this stage there are only minimal effects to the entire body. 2  Chronic renal failure. 3  In stage two of the disease, damage to the kidneys has progressed to a level that causes problems throughout the body.