Causes of Ankle Pain. 1  Ankylosing Spondylitis Ankylosing spondylitis is a type of arthritis that causes chronic inflammation of the spine. 2  Arthritis Arthritis is inflammation of one or more joints. 3  Broken Bone (Types of Bone Fractures) A broken bone is a fracture.
Down syndrome is a chromosomal condition that is associated with intellectual disability, a characteristic facial appearance, and weak muscle tone (hypotonia) in infancy. All affected individuals experience cognitive delays, but the intellectual disability is usually mild to moderate.
Down Syndrome Mutation. Down Syndrome is caused by a trisomy. Another name for down syndrome is Trisomy 21. When a child receives its chromosomes pairs from their parents and a trisomy occurs...you receive 3 chromosomes instead of the two that are normally in a pair. When this happens on the 21st chromosome, it will most likely result in down syndrome. The mutation is a trisomy.