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Until recent years, the standard treatment for a UTI was 10 days of amoxicillin, a penicillin antibiotic, but it is now ineffective against E. coli bacteria in many cases. A combination of amoxicillin-clavulanate (Augmentin) is sometimes given for drug-resistant infections.
Antibiotics are used to treat urinary tract infection (UTI) and, in select patients, to prevent recurrence. Avoid nephrotoxic drugs whenever possible. On occasion, analgesic therapy may be used to provide relief because of voiding symptoms. Start antibiotics after performing urinalysis and obtaining a urine specimen for culture in patients with UTI. A 7- to 10-day course of antibiotics is recommended, even for an uncomplicated infection. Short-course treatments should be reserved for nontoxic-appearing adolescent girls with UTI. Be aware of increasing rates of antibiotic resistance and the need to choose antibiotic therapy accordingly.