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Until recent years, the standard treatment for a UTI was 10 days of amoxicillin, a penicillin antibiotic, but it is now ineffective against E. coli bacteria in many cases. A combination of amoxicillin-clavulanate (Augmentin) is sometimes given for drug-resistant infections.
The following oral antibiotics are commonly used to treat most UTI infections (acute cystitis): Sulfamethoxazole-trimethoprim (Bactrim DS, Septra DS, others) Nitrofurantoin (Macrobid, Macrodantin) Fosfomycin (Monurol) Amoxicillin/clavulanate (Augmentin) Certain cephalosporins like cefpodoxime, cefdinir, or cefaclor.