Causes of Ankle Pain. 1  Ankylosing Spondylitis Ankylosing spondylitis is a type of arthritis that causes chronic inflammation of the spine. 2  Arthritis Arthritis is inflammation of one or more joints. 3  Broken Bone (Types of Bone Fractures) A broken bone is a fracture.
Down syndrome is a chromosomal condition that is associated with intellectual disability, a characteristic facial appearance, and weak muscle tone (hypotonia) in infancy. All affected individuals experience cognitive delays, but the intellectual disability is usually mild to moderate.
Down syndrome is a genetic disorder that includes a combination of birth defects. Persons with Down syndrome have some degree of mental retardation and characteristic facial features. Often, heart defects and other problems are present. It is one of the most common genetic birth defects, affecting approximately 1 in 800 babies. Chromosomes are the structures in cells that contain the genes. Down syndrome is caused by extra genetic material from chromosome 21. Affected persons have two normal copies of number 21 chromosomes, plus extra chromosome number 21 material attached to another chromosome.