In situations where the concomitant use of clarithromycin with statins cannot be avoided, it is recommended to prescribe the lowest registered dose of the statin. Use of a statin that is not dependent on CYP3A metabolism (e.g. fluvastatin or pravastatin) should be considered (see section 4.5).
On the basis of these data, they assumed the ancient model of and estimated both a recent epoch of exponential growth and the population size before growth, pointing to growth starting 3.5 (2.9â4.1) kya at a rate of 3.4% (2.4â5.1%) per generation, resulting at 0.65 (0.30â2.87) millions individuals today (Figure 1b and Table 2).
Projections of the group quarters population above age 65 were based on their share of the 2010 Census total population. Forecasts of the number of households and household size were derived from the cohort-headship method. Released in December 2011, these population projections forecast population change through 2050 in 5-year intervals for Kentucky, Area Development Districts, and Counties.