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The hypothalamus releases thyrotropin releasing hormone (TrH), which travels via a venous plexus to the anterior lobe of the pituitary gland and stimulates release of thyroid stimulating hormone (TSH). TSH then induces production of thyroxine (T4) by the thyroid.ased on the functional interrelationship of the hypothalamus, pituitary gland, and thyroid, TSH should be elevated if the thyroid gland is not producing adequate thyroid hormone, and suppressed if it is producing too much (Figure 1).
The interrelationships of thyroid and growth hormones: effect of growth hormone releasing hormone in hypo-and hyperthyroid male rats.Root AW, Shulman D, Root J, Diamond F. Growth hormone (GH) and the thyroid hormones interact in the hypothalamus, pituitary and peripheral tissues.Thyroid hormone exerts a permissive effect upon the anabolic and metabolic effects of GH, and increases pituitary synthesis of this protein hormone.GH depresses the secretion of thyrotropin and the thyroid hormones and increases the peripheral conversion of thyroxine to triiodothyronine.he interrelationships of thyroid and growth hormones: effect of growth hormone releasing hormone in hypo-and hyperthyroid male rats.