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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
Ibuprofen tablets, capsules and liquid: Take this medication orally usually every 4-6 hours, preferably after food. Ibuprofen tablets or capsules should be taken with a glass of water. Ibuprofen granules should be mixed with water to make a drink. Leave at least 4 hours between each dose.