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Keratosis pilaris results from the buildup of keratin â a hard protein that protects skin from harmful substances and infection. The keratin forms a scaly plug that blocks the opening of the hair follicle. Usually many plugs form, causing patches of rough, bumpy skin. No one knows exactly why keratin builds up. But it may occur in association with genetic diseases or with other skin conditions, such as atopic dermatitis.
The KRT10 gene provides instructions for making a protein called keratin 10. Keratins are a group of tough, fibrous proteins that form the structural framework of cells called keratinocytes that make up the skin, hair, and nails. Keratin 10 is produced in keratinocytes in the outer layer of the skin (the epidermis).In the fluid-filled space inside these cells (the cytoplasm), the keratin 10 protein partners with a similar protein, keratin 1 (produced from the KRT1 gene), to form molecules called keratin intermediate filaments.pidermolytic hyperkeratosis-caused by mutations in the KRT10 gene. Dozens of mutations in the KRT10 gene have been found in people with epidermolytic hyperkeratosis. This condition is characterized by red, blistering skin at an early age and thick skin (hyperkeratosis) later in life.