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BMS-955176 is a maturation inhibitorâthe drug prevents HIV from producing complex âpolyproteinsâ that are cut up by protease enzymes and assembled into new virus particles. If approved, BMS-955176 would be the first HIV medication to work by preventing virus assembly, maturation, and release from infected cells.
Drug resistance means a personâs HIV treatment no longer prevents the virus from multiplying. This usually happens if treatment has not been taken correctly, allowing the virus to mutate. Stages of the HIV life cycle. 1. Binding and fusion. First, the HIV virus attaches itself to a T-helper cell and releases HIV into the cell. Drugs that can stop this part of the process are called fusion or entry inhibitors. 2. Conversion and integration. Once inside the cell, HIV changes its genetic material so it can enter the nucleus of the cell and take control of it.