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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
4 hours to leave your body so long.... 4. 1. It takes acetaminophen which is Tylenol, 4 hours to leave your body so long as it is not a 12 hour time release pill. In that case, it would take 12 hours.Do not take another pill until the proper time is up. You can get liver damage from taking too much Tylenol and also if you take it for too long. hours to leave your body so long.... 4. 1. It takes acetaminophen which is Tylenol, 4 hours to leave your body so long as it is not a 12 hour time release pill. In that case, it would take 12 hours.