In the simplest of terms, a drug's volume of distribution is that volume of bodily fluid into which a drug dose is dissolved. Therefore, if we know the dose that was given, and we can measure the serum level (concentration), then we can calculate a volume: Volume of distribution = Dose / drug concentration.
As soon as you can make the reservation, do it, but the general consensus is at least three to six months in advance of the date. By three months out, couples have a good idea how many guests will be attending and they can plan a menu that doesnât conflict with their wedding day.
The parties must confer as soon as practicable â and in any event at least 21 days before a scheduling conference is to be held or a scheduling order is due under Rule 16(b). The parties should attempt to agree on the proposed discovery plan, and submit it to the court within 14 days after the conference.