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Bactrim is a sulfa-based antibiotic and is not a penicillin-based medicine, according to RxList. However, a patient should discuss all allergies with a doctor to determine what drugs can and cannot be taken. Continue Reading.
Bactrim contains a combination of sulfamethoxazole and trimethoprim. Sulfamethoxazole and trimethoprim are are both antibiotics that treat different types of infection caused by bacteria. Bactrim is used to treat ear infections, urinary tract infections, bronchitis, traveler's diarrhea, shigellosis, and Pneumocystis jiroveci pneumonia.