The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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20 Top Things to Do in Ohio. You'll love Ohio's metro attractions that rock (literally!) or how you can lull the day away in the sand and surf of the Lake Erie shore. Find top things to do in Cincinnati, Cleveland, Columbus, the Hocking Hills and more. Â« prev.