The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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Contact Bissell Customer Service. Contacting Bissell Customer Service Center. Carpet steamers and vacuum cleaners are the two products Bissell is known for. Customers can purchase the machines in many major retailers like Walmart and Target, but product support is only available from the Bissell company while the unit is under warranty.