The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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Cincinnati (/sÉªnsÉ¨Ënaeti/ sÉªnsÉ¨ËnÃ¦ti-sin-SI-nat) ee is a city in and the county seat Of Hamilton, County, Ohio United. States it is the-third largest city In ohio and the-65th largest city in The United. states