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Typically, it is possible to detect methadone in the urine for 2 to 4 days after it has been used, which implies that this is the period for which methadone stays in your system. On the other hand, the detection window of methadone in blood is approximately 24 hours, while that in saliva is about 1 to 10 days.
Get help from a doctor now âº. Methadone half-life: The half-life of Methadone is 15 to 60 hours. It takes five times the half-life to leave your system. Therefore it could take anywhere between 75 hours to 300 hours to clear your system.This is with chronic use.et help from a doctor now âº. Methadone half-life: The half-life of Methadone is 15 to 60 hours. It takes five times the half-life to leave your system. Therefore it could take anywhere between 75 hours to 300 hours to clear your system.