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BMS-955176 is a maturation inhibitorâthe drug prevents HIV from producing complex âpolyproteinsâ that are cut up by protease enzymes and assembled into new virus particles. If approved, BMS-955176 would be the first HIV medication to work by preventing virus assembly, maturation, and release from infected cells.
Protease inhibitors are drugs that resemble pieces of the protein chain that protease normally cuts. By gumming up the protease scissors, HIV protease inhibitors prevent protease from cutting long chains of proteins and enzymes into the shorter pieces that HIV needs to make new copies of itself (Figure 1) .rotease inhibitors are drugs that slow down the spread of HIV -- the virus that causes AIDS -- inside the body.