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After treatment, a small number of people still have some symptoms, such as muscle aches and fatigue. The cause of these continuing symptoms, known as post-treatment Lyme disease syndrome, is unknown, and treating with more antibiotics doesn't help.Some experts believe that certain people who get Lyme disease are predisposed to develop an autoimmune response that contributes to their symptoms.More research is needed.he cause of these continuing symptoms, known as post-treatment Lyme disease syndrome, is unknown, and treating with more antibiotics doesn't help. Some experts believe that certain people who get Lyme disease are predisposed to develop an autoimmune response that contributes to their symptoms. More research is needed.
The symptoms of Lyme disease depend on the stage of the disease. You may first notice symptoms weeks to months after the tick bite. If the disease isn't treated, it may progress from mild symptoms to serious, long-term disabilities. In the first stage, you may have a rash (erythema migrans) at the site of the tick bite. You may also have a lack of energy or a headache and stiff neck. Sometimes people have no symptoms at this stage. In the second stage, symptoms may include memory problems and pain and weakness in the arms and legs.