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Within eukaryotes, DNA replication is controlled within the context of the cell cycle. As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase).
Quick Answer. DNA is replicated during interphase, the phase of the cell cycle that precedes the four stages of mitosis: anaphase, prophase, prometaphase and telophase. According to CyberBridge, a life sciences website maintained by Harvard University, DNA replication occurs during the S phase of interphase. Continue Reading.