The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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Kroger is also the third largest retailer in the world. As of December 2015, Kroger operates, either directly or through its subsidiaries, 2,778 supermarkets and multi-department stores. Kroger's headquarters are in downtown Cincinnati.