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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
In simple words too much acetaminophen will cause toxicity to the liver which can be damaging. 2gm of tylenol equals 4 500mg capsules a day, but you can take 4 doses of Tylenol a day of 2 capsules at a time.I wouldn`t do this for more than 3 days. You should drink 1 full glass of water when taking acetaminophen.ou can not get addicted to Tylenol, its effect on you does not diminish.Since Tylenol is not an asprin product, you can take a dose of asprin at the alternate 4 hour intervals with Tylenol.(Like T at 8, A at10, T at 12, A at 2) for a headache try caffeine.