The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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More Lists from Steven B. 1  These are the reviews I written in 2017. 2  These are the businesses that help me make my yard enjoyable and beautâ¦ 12 businesses. 3  2016 is a Leap Year and I am going to see if I can average a review a â¦ 217 businesses. 4  These are businesses that have dog friendly patios.