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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
Best Answer: Well if you are really sore you can take 3 ibuprofen 3x a day. At least that's what my doctor told me to do. Also because aspirin and ibuprofen are not the same, you can take them close together so I would take the ibuprofen right now. I usually don't use aspirin. I will take 2 tylenol and then 2 hours later take my ibuprofen.