In the simplest of terms, a drug's volume of distribution is that volume of bodily fluid into which a drug dose is dissolved. Therefore, if we know the dose that was given, and we can measure the serum level (concentration), then we can calculate a volume: Volume of distribution = Dose / drug concentration.
As soon as you can make the reservation, do it, but the general consensus is at least three to six months in advance of the date. By three months out, couples have a good idea how many guests will be attending and they can plan a menu that doesnât conflict with their wedding day.
In summer, especially on weekends, it's a good idea to reserve your tickets in advance, especially for the high-speed ferries. Whichever ferry you take, be at the dock at least 30 minutes before departure time to check luggage, load bikes, check tickets, and get in line to board and find the seat you want.