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Bactrim is a sulfa-based antibiotic and is not a penicillin-based medicine, according to RxList. However, a patient should discuss all allergies with a doctor to determine what drugs can and cannot be taken. Continue Reading.
Bactrim contains two different antibiotics, sulfamethoxazole and trimethoprim. Sulfamethoxazole belongs to a group of drugs known as sulfonamides (sulfa drugs). Trimethoprim does not belong to a specific class of medications. These two antibiotics work in different but similar ways. Essentially, both sulfamethoxazole and trimethoprim work by inhibiting the production of folic acid in bacteria, although they work in different stages of folic acid production.