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Keratosis pilaris results from the buildup of keratin â a hard protein that protects skin from harmful substances and infection. The keratin forms a scaly plug that blocks the opening of the hair follicle. Usually many plugs form, causing patches of rough, bumpy skin. No one knows exactly why keratin builds up. But it may occur in association with genetic diseases or with other skin conditions, such as atopic dermatitis.
Hyperkeratosis Causes. Hyperkeratosis is a form of keratosis. Keratosis is a disorder of the skin caused by the overproduction of keratin. Hyperkeratosis is linked with qualitative abnormality of the keratin and causes thickening of the stratum corneum or the horny layer of the skin.t is caused by too much buildup of keratin in the outer layers of skin. The thickening of this skin defends it from rubbing, irritation as well as pressure. Most of the types of this condition are painless.