Speech Difficulties in Down Syndrome. Down syndrome (DS) is an incurable genetic disorder that has a profound impact upon a personâs physical, mental, and social development. Children with DS have anatomical and physiological differences in the mouth and throat region that affect feeding, swallowing, and oral motor skills.
1 A gross refers to a group of 144 items (a dozen dozen or a square dozen).  A great gross refers to a group of 1728 items (a dozen gross or a cubic dozen).
Gross margin is the difference between revenue and cost of goods sold (COGS) divided by revenue. Gross margin is expressed as a percentage. Generally, it is calculated as the selling price of an item, less the cost of goods sold (e.g. production or acquisition costs, not including indirect fixed costs like office expenses, rent, or administrative costs).