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After treatment, a small number of people still have some symptoms, such as muscle aches and fatigue. The cause of these continuing symptoms, known as post-treatment Lyme disease syndrome, is unknown, and treating with more antibiotics doesn't help.Some experts believe that certain people who get Lyme disease are predisposed to develop an autoimmune response that contributes to their symptoms.More research is needed.he cause of these continuing symptoms, known as post-treatment Lyme disease syndrome, is unknown, and treating with more antibiotics doesn't help. Some experts believe that certain people who get Lyme disease are predisposed to develop an autoimmune response that contributes to their symptoms. More research is needed.
The early stages of Lyme disease usually include the bullâs-eye rash (erythema migrans) and flu-like symptoms of chills and fever, fatigue, muscle pain, and headache. In rare cases, patients develop an abnormal heartbeat (Lyme carditis). All of these conditions are treated with 10 - 28 days with antibiotics. Other symptoms may accompany the rash, such as joint pain, fever, chills, or fatigue. 2  If Lyme disease is not treated, more severe symptoms and complications can occur. 3  These include arthritis, neurologic symptoms, or heart problems.