The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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Commercial Cleaning. Another rewarding business, which includes cleaning of offices and business buildings and premises. This business is quite beneficial for business owners in the big city. The service is usually done after the working hours, at night or at weekends and it involves general housekeeping duties of the office premises.