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Risk Factors. 1  Age: renal cancer is most common in the 55-60 year age range. 2  Gender: more frequent in men than women (2:1). 3  Race: caucasian men are at somewhat higher risk than African-Amerian men (transitional cell carcinoma is twice as common among Caucasian men as among African-American men). Age: renal cancer is most common in the 55-60 year age range. 2  Gender: more frequent in men than women (2:1). 3  Race: caucasian men are at somewhat higher risk than African-Amerian men (transitional cell carcinoma is twice as common among Caucasian men as among African-American men).
Doctors don't know the causes of kidney cancer. But certain factors appear to increase the risk of getting kidney cancer. For example, kidney cancer occurs most often in people over 40. These are some other risk factors for kidney cancer. 1  Smoking. 2  If you smoke cigarettes, your risk of getting kidney cancer is twice that of nonsmokers. 3  Cigars may also increase your risk. 4  Being male. 5  The disease is more common in men than in women.