The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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Cincinnati may not have the high crime rates of other metropolitan areas, but crime does exist. There are both safe places and areas to avoid in Cincinnati. Before you visit, you need to know the information that can help keep you safe. Cincinnati, like any major metropolitan area, has its share of crime.