The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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Cincinnati, Ohio is situated right on the Ohio River at the Ohio-Kentucky border. There are approximately 332,458 Cincinnatians in Cincinnati. Explore the entire state in the Ohio yellow pages. Cincinnati was the first major inland city in the United States and also the first major boomtown. Sports fanatics will delight in Cincinnatiâs major sports teams â the Cincinnati Reds and the Cincinnati Bengals.