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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
If a fever is particularly high or persistent, you can give both Tylenol and Motrin, but be very careful that Tylenol is not dosed more than every 4 hours, or Motrin more than every 6 hours. It is helpful to keep a medication log.Of note, fever reducers generally reduce a fever by 2-3 degrees.f, you can give Tylenol every 4-6 hours or ibuprofen (Motrin, Advil) every 6-8 hours. Most fevers can be managed by giving only Motrin or only Tylenol. Both work equally well as fever reducers, but Motrin lasts a little longer.