The Japanese word for Japan is æ¥æ¬, which is pronounced Nippon or Nihon and literally means the origin of the sun. The earliest record of the name Nihon appears in the Chinese historical records of the Tang dynasty, the Old Book of Tang.
The secondary immune response occurs the second time (3rd, 4th, etc.) the person is exposed to the same antigen. At this point immunological memory has been established and the immune system can start making antibodies immediately.
The immune system uses a different approach to deal with these kinds of pathogens. Cell-mediated responses are the primary defense against intracellular pathogens and the approach is different depending upon where the pathogen resides in the host cell (i.e., in the cytosol or within vesicles).