In the simplest of terms, a drug's volume of distribution is that volume of bodily fluid into which a drug dose is dissolved. Therefore, if we know the dose that was given, and we can measure the serum level (concentration), then we can calculate a volume: Volume of distribution = Dose / drug concentration.
As soon as you can make the reservation, do it, but the general consensus is at least three to six months in advance of the date. By three months out, couples have a good idea how many guests will be attending and they can plan a menu that doesnât conflict with their wedding day.
The RNC subcommittee passed a requirement that delegates be selected at least 45 days before the convention, up from 35 days now. If Priebus gets his wish of a late June convention, this would technically force state parties to pick delegates by mid-May.But a handful of states mandate June primaries by law.he committee voted Thursday to make the penalty even stricter for smaller states, to dissuade them from attempting to move up. Republican leaders in the four earliest-voting states express confidence they will now be able to hold off on voting until February of 2016, compared to January in 2012.