The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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Downtown Kroger store in the works. A Downtown Kroger store could emerge in what is now a parking lot at Walnut Street and Central Parkway. Kroger headquarters Downtown. Kroger may be moving closer to opening a new supermarket in the heart downtown Cincinnati.