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Yes: You can take them together. Allegra 24 hour is a nonsedating antihistamine and Sudafed PE is a decongestant. This would be similar to taking allegra D. What you do not want to do is take Allegra D with sudafed, then you would get too much decongestant.Also you want to avoid decongestants if you have certain conditions like hypertension.Also don't take the sudafed at bedtime....Read more.hat you do not want to do is take Allegra D with sudafed, then you would get too much decongestant. Also you want to avoid decongestants if you have certain conditions like hypertension. Also don't take the sudafed at bedtime. ...Read more.
They also found that Allegra and Zyrtec were comparable in relieving the symptoms of seasonal allergies. Whereas drowsiness was a side effect of Zyrtec, no major side effects were noted with Allegra. Patients also experienced less fatigue, nausea, and throat irritations with Allegra. However, in the U.S., Allegra is only available in 60 mg capsules taken twice a day and not in the 120 mg or 180 mg once-daily capsules.