The Japanese word for Japan is æ¥æ¬, which is pronounced Nippon or Nihon and literally means the origin of the sun. The earliest record of the name Nihon appears in the Chinese historical records of the Tang dynasty, the Old Book of Tang.
The secondary immune response occurs the second time (3rd, 4th, etc.) the person is exposed to the same antigen. At this point immunological memory has been established and the immune system can start making antibodies immediately.
Studies on immune responses in afferent and efferent lymph of lymph nodes draining the tissues have contributed to the concept that primary immune responses are generated in the lymph nodes with a delay before antigen-specific effector cells arrive at the affected tissue.