Good Faith Estimate (GFE) Good Faith Estimate (HUD-GFE) 1. This GFE gives you an estimate of your settlement charges and loan terms if you are approved for this loan. For more information, see HUDâs Special Information Booklet on settlement charges, your Truth-in-Lending. Disclosures, and other consumer information at www.hud.gov/respa.
Approved Uses for Otezla. Otezla Â® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.pproved Uses. Otezla Â® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.
Thus, an inhibitor of PDE4 results in an increase in cAMP, which is similar to CF101's mechanism of action (discussed below). Otezla(R) was approved for the treatment of psoriatic arthritis in March 2014, and then for the treatment of psoriasis in September 2014. The drug was approved for the treatment of psoriasis based on two Phase 3 clinical trials involving over 1,200 patients.