In the simplest of terms, a drug's volume of distribution is that volume of bodily fluid into which a drug dose is dissolved. Therefore, if we know the dose that was given, and we can measure the serum level (concentration), then we can calculate a volume: Volume of distribution = Dose / drug concentration.
As soon as you can make the reservation, do it, but the general consensus is at least three to six months in advance of the date. By three months out, couples have a good idea how many guests will be attending and they can plan a menu that doesnât conflict with their wedding day.
When to Have It. The engagement party should fall within a few months of the proposal, right in the sweet spot between carefree, just-engaged life and the start of serious wedding planning. You'll want to give guests about a month's notice, so about 9 to 11 months before the wedding is the ideal time frame.he engagement party should fall within a few months of the proposal, right in the sweet spot between carefree, just-engaged life and the start of serious wedding planning. You'll want to give guests about a month's notice, so about 9 to 11 months before the wedding is the ideal time frame.