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BMS-955176 is a maturation inhibitorâthe drug prevents HIV from producing complex âpolyproteinsâ that are cut up by protease enzymes and assembled into new virus particles. If approved, BMS-955176 would be the first HIV medication to work by preventing virus assembly, maturation, and release from infected cells.
Though the researchers are not sure why crack cocaine was the only drug among those studied to affect HIV progression independent of treatment adherence, Dr. Baum speculates that it may be associated with the frequency of use.