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Within eukaryotes, DNA replication is controlled within the context of the cell cycle. As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase).
DNA replication occurs in the 5' to 3' direction because 3' to 5' replication is chemically impossible. Explain your answer. Lagging strand synthesis is more complex because of the requirement for DNA replication to take place in the 5' to 3' direction.Since parent strands are oriented in an anti-parallel fashion, one strand is oriented in the 5' to 3' direction, while the other strand is oriented in the 3' to 5' direction.hile DNA replication does occur in the 5' to 3' direction, the reason is not because 3' to 5' replication is chemically impossible. 3' to 5' replication can in principle occur. The 3' OH of the incoming nucleotide instead of the nucleotide attached to the end of the growing chain would be the attacking group.