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100% activity is attained after 24 hours. It is also described therein that, 6 hours after oral administration to cats, nitenpyram reaches an activity of 60% against the fleas present on the cats, and on the second day after renewed infestation it still gives 55% activity.
Common Questions and Answers about Protonix how long does it take to work. protonix. I was switched to Protonix and it seemed to help with the upper stomach pain right under the breastbone. I'm taking two pills a day. Does anyone know how long Protonix takes to work? I was told that some PPI's could take 4 to six weeks to take affect.