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ANCA : Antineutrophil cytoplasmic antibodies (ANCA) can occur in patients with autoimmune vasculitis including Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), or organ-limited variants thereof such as pauci-immune necrotizing glomerulonephritis.(1) Detection of ANCA is a well-established diagnostic test for the evaluation of patients suspected of having autoimmune vasculitis.
1 The cytoplasmic pattern (cANCA) is associated with PR3 antibodies and the perinuclear pattern (pANCA) is associated with MPO antibodies. 2  Another possible pattern is atypical ANCA. 3  Myeloperoxidase antibodies and proteinase 3 (PR3) antibodies may be individually and specifically tested using an immunoassay method.