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ANCA : Antineutrophil cytoplasmic antibodies (ANCA) can occur in patients with autoimmune vasculitis including Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), or organ-limited variants thereof such as pauci-immune necrotizing glomerulonephritis.(1) Detection of ANCA is a well-established diagnostic test for the evaluation of patients suspected of having autoimmune vasculitis.
Inflammatory Bowel Disease. An ANCA test may be ordered with a test for anti-Saccharomyces cerevisiae antibodies (ASCA) when a person has signs and symptoms that suggest inflammatory bowel disease and the health practitioner is attempting to distinguish between Crohn disease and ulcerative colitis.egative ANCA tests results mean it is unlikely that a person's symptoms are due to an autoimmune vasculitis. For a positive result on the indirect immunofluorescence microscopy method, several different ANCA patterns may be seen: 1  Perinuclear (pANCA) â most of the fluorescence occurs near the nucleus.