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100% activity is attained after 24 hours. It is also described therein that, 6 hours after oral administration to cats, nitenpyram reaches an activity of 60% against the fleas present on the cats, and on the second day after renewed infestation it still gives 55% activity.
How to Use the Dose Pack. A Medrol Dose Pack contains 21 4-milligram pills that last for six days. The patient starts with six pills (24 milligrams) and takes one fewer each day, until the pack is finished. The pills are taken orally with a full glass of water before breakfast, after lunch, after dinner and at bedtime (according to the day).