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Symptoms. Usually there are no symptoms. If the protein loss is heavy, the urine has a frothy appearance, and would most likely be associated with other symptoms e.g. oedema, where there is an excess of water in the body tissues. Possible causes of proteinuria
Proteinuria is a sign of glomerulonephritis, also called nephritis (inflammation of the kidney). Diabetes, hypertension and various kidney diseases can cause the inflammation, which can lead to renal failure and, ultimately, end-stage renal disease (ESRD).