The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans).
Connective tissue disease. A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
However, most forms of collagen vascular disease do share some of the same general symptoms. People with collagen vascular disorders typically experience: fatigue; muscle weakness; fever; body aches; joint pain; skin rash; Symptoms of lupus. Lupus is a collagen vascular disease that causes unique symptoms in each patient. Additional symptoms can include: