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Unicellular organisms are composed of a single cell. Multicellular organisms are composed of many specialized cells. Specialized cells differ in structure (size, shape...) and function (the role they perform in the organism).
1. Unicellular organisms have one cell, while multicellular organisms are composed of many different types of cells. 2. Unicellular organisms are mostly prokaryotes, while multicellular organisms are generally classified as eukaryotes.