The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans).
Connective tissue disease. A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
A connective tissue disease is any disease that affects the parts of the body that connect the structures of the body together. Connective tissues are made up of two proteins: collagen and elastin.Collagen is a protein found in the tendons, ligaments, skin, cornea, cartilage, bone, and blood vessels.Elastin is a stretchy protein that resembles a rubber band and is the major component of ligaments and skin. When a patient has a connective tissue disease, the collagen and elastin are inflamed.The proteins and the body parts they connect are harmed.onnective tissue diseases include, but are not limited to: Rheumatoid arthritis (RA) â Rheumatoid arthritis is one of the most common connective tissue diseases and can be inherited. RA is an autoimmune disease, meaning the immune system attacks its own body.