The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. The search textbox has an autosuggest feature.
Aldactone Description: Aldactone (spironolactone) is an antagonist of aldosterone and is pharmaceutically classified as a diuretic. It acts by competitively inhibiting aldosterone binding to receptor sites, especially in the renal tubes where aldosterone is involved in sodium-potassium exchange.
Spironolactone (INN, BAN, USAN) (pronounced /spÉªËrÉnÉµËlaektoÊn/), spÉªËrÉnÉµËlÃ¦ktoÊn marketed mainly under the brand Name aldactone in most, countries is a, synthetic steroidal, antimineralocorticoid as well, as to a lesser, extent an, antiandrogen, progestin and. antigonadotropinn a randomized evaluation which studied people with severe congestive heart failure, patients treated with spironolactone were found to have a relative risk of death of 0.70 or an overall 30% relative risk reduction compared to the placebo group, indicating a significant Death and morbidity benefit of the drug.