The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans).
Connective tissue disease. A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
Collagen Vascular Disease. Collagen vascular disease is an autoimmune disease the mainly affects the collagen in the body. An autoimmune disease is a disorder which causes the bodyâs immune system to mistakenly destroy or attack its own body. Collagen vascular disease is also known as a connective tissue disease.