The adrenals secrete over 400 different hormones, so any deficiency will be felt in a wide variety of ways. The most common symptom of Adrenal Fatigue is extreme fatigue, but insomnia can also be an unfortunate symptom.
Dec. 11, 1816 (19'th state to join the U.S.).
1 Then a compromise developed: Maine could join as a free state to balance out Missouri joining as a slave state.  By 1820, the compromise had been realized. First, Missouri and Maine would be admitted to the Union, one as slave and one as free.