The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans).
Connective tissue disease. A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
SHARE IT. a a a. Peripheral vascular disease, also known as peripheral arterial disease, or PVD, is a condition of the blood vessels that leads to narrowing and hardening of the arteries that supply the legs and feet.Because it decreases blood flow, PVD can injure nerves and other tissues.HARE IT. a a a. Peripheral vascular disease, also known as peripheral arterial disease, or PVD, is a condition of the blood vessels that leads to narrowing and hardening of the arteries that supply the legs and feet.