4.2a Serotonin. Even though increased dopamine in the brain reward system is generally thought to be the final common pathway for the reinforcing properties of drugs, other neurotransmitters such as serotonin are involved in the modulation of both drug self-administration and dopamine levels.ike other drugs of abuse, stimulants increase dopamine concentrations in the brain reward pathway (1,2,3,4,7). Stimulants such as cocaine, amphetamines, caffeine and nicotine all stimulate the brain reward pathway through slightly different mechanisms and increase dopamine to different extents.
1 Gout is a form of arthritis caused by excess uric acid in the bloodstream. 2  The symptoms of gout are due to the formation of uric acid crystals in the joints. 3  Gout most commonly affects the joint in the base of the big toe.4  Gout attacks often occur without warning in the middle of the night.ore detail and supporting information is in the main article. 1  Gout is a form of arthritis caused by excess uric acid in the bloodstream. 2  The symptoms of gout are due to the formation of uric acid crystals in the joints.
Report Abuse. Gout is caused by high blood levels of uric acid that crystallize and form painful deposits in the joints. Traditional thinking tells us that gout is the result of excessive amounts of alcohol, protein, heavy foods, coffee and soft drinks in your diet.