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Unicellular organisms are composed of a single cell. Multicellular organisms are composed of many specialized cells. Specialized cells differ in structure (size, shape...) and function (the role they perform in the organism).
The statement which best compares a multicellular organism to a  single-celled organism is their functions. While multicellular  organisms use organ systems to perform life â¦functions,  single-celled organisms do not use organs for the life functions.