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Many of these potential Lipitor side effects can affect the liver, including: 1  An increase in liver enzymes. 2  Hepatitis, which is an inflammation of the liver that can cause tiredness or a general feeling of illness.  Jaundice, or yellowing of the skin or eyes that can occur from the liver being damaged.
A Stacy Wiegman, PharmD, Pharmacy, answered. Lipitor can be hard on the liver and carries a slight risk of causing liver damage. This is why it is not often prescribed to people with a history of liver disease or elevated liver enzyme counts.This is also why having more than two alcoholic beverages a day is not recommended while on Lipitor, as the combination of the medication and alcohol, which stresses the liver, can damage the organ.his is why it is not often prescribed to people with a history of liver disease or elevated liver enzyme counts. This is also why having more than two alcoholic beverages a day is not recommended while on Lipitor, as the combination of the medication and alcohol, which stresses the liver, can damage the organ.