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ANCA : Antineutrophil cytoplasmic antibodies (ANCA) can occur in patients with autoimmune vasculitis including Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), or organ-limited variants thereof such as pauci-immune necrotizing glomerulonephritis.(1) Detection of ANCA is a well-established diagnostic test for the evaluation of patients suspected of having autoimmune vasculitis.
Tests for antineutrophil cytoplasmic antibodies (ANCA) may be used to: 1  Help detect and diagnose certain forms of autoimmune vasculitis, including granulomatosis with polyangiitis (Wegener granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg Strauss syndrome).n addition, tests that are specific for antibodies to MPO and PR3 may be performed: 1  A positive test for PR3 antibodies and a positive cANCA or pANCA are seen in more than 80% of patients with active granulomatosis with polyangiitis (Wegener granulomatosis).