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ANCA : Antineutrophil cytoplasmic antibodies (ANCA) can occur in patients with autoimmune vasculitis including Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), or organ-limited variants thereof such as pauci-immune necrotizing glomerulonephritis.(1) Detection of ANCA is a well-established diagnostic test for the evaluation of patients suspected of having autoimmune vasculitis.
Bottom right-MPO antibodies on formalin-fixed neutrophils (c-ANCA pattern).(FITC conjugate). Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the cytoplasm of neutrophil granulocytes (the most common type of white blood cell) and monocytes.op left-PR3 antibodies on ethanol-fixed neutrophils (c-ANCA pattern). Bottom left-PR3 antibodies on formalin-fixed neutrophils(c-ANCA pattern). Top right-MPO antibodies on ethanol-fixed neutrophils (p-ANCA pattern).