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100% activity is attained after 24 hours. It is also described therein that, 6 hours after oral administration to cats, nitenpyram reaches an activity of 60% against the fleas present on the cats, and on the second day after renewed infestation it still gives 55% activity.
Cycles vary from 21 days to 36 days. For example in a 21 day cycle the cream should be used from day 8 for 14 days, if a 28 day cycle from day 15 for 14 days and if a 36 days cycle from day 22 for 14 days. Use 100-200mg/3-6ml per day, more maybe needed depending on how severe symptoms are.se from 10 - 100mg/ 0.3 - 3ml per day. It is best to use the cream twice a day. Please read How to Use Progesterone Cream so that you fully understand how it works!! You will also find a chart indicating how long a tube of Natpro will last you using different amounts and is show the teaspoon, mg and ml conversion.