The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans).
Connective tissue disease. A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
Collagen vascular disease is an autoimmune disease. This means that your immune system mistakenly attacks your bodyâs healthy tissue. No one knows what causes your immune system to do this. The attacks usually cause inflammation. If you have a collagen vascular disease, your immune system causes inflammation in your collagen and nearby joints.