The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans).
Connective tissue disease. A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
Vascular disease includes any condition that affects the circulatory system. As the heart beats, it pumps blood through a system of blood vessels called the circulatory system. The vessels are elastic tubes that carry blood to every part of the body.Arteries carry blood away from the heart while veins return it.Vascular disease ranges from diseases of your arteries, veins, and lymph vessels to blood disorders that affect circulation.The following are conditions that fall under the category of vascular disease.ascular disease ranges from diseases of your arteries, veins, and lymph vessels to blood disorders that affect circulation. The following are conditions that fall under the category of vascular disease.