The UK's most valuable monument is deemed to be the 1,000-year-old Tower of London, which is worth an estimated Â£56billion to the British economy and came it at number five in the list of European list. Its value is six times more than its nearest rival the Colosseum in Rome, which is valued at Â£72billion.
Cell cycle checkpoints are control mechanisms in eukaryotic cells which ensure proper division of the cell.
In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.PMCID: PMC3078634.he gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis.