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Pork loin should be cooked for approximately 30 minutes per pound in an oven that has been preheated to 350 degrees. A good way to ensure that a pork loin is properly cooked is to use a meat thermometer. The meat will be done when the thermometer reaches a temperature of 155 to 165 degrees. Continue Reading.
1 Pour soy sauce and melted butter over the tenderloin. 2  Bake in preheated oven for 10 minutes, then turn the roast over, and continue cooking 35 to 40 minutes, basting occasionally until the internal temperature of the roast is at 140 degrees F (60 degrees C) for medium. 3  Or, cook to your desired degree of doneness.