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100% activity is attained after 24 hours. It is also described therein that, 6 hours after oral administration to cats, nitenpyram reaches an activity of 60% against the fleas present on the cats, and on the second day after renewed infestation it still gives 55% activity.
Repellents such as DEET that are used on the skin will be effective for anywhere from 90 minutes to 10 hours, depending on the amount of active ingredient in the product and skin condition. Permethrin products sprayed on clothing generally may be expected up to 6 hours following application.