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Unicellular organisms are composed of a single cell. Multicellular organisms are composed of many specialized cells. Specialized cells differ in structure (size, shape...) and function (the role they perform in the organism).
The biggest similarity between them is that they both contain cell. A unicellular organism only has one cell, a multicellular organism has many cells. Multicellular organisms have specialized cells to carry out different jobs (ie.humans have cardiac muscle cells in the heart, and nervous cells in the brain).est Answer: unicellular (bacteria and some eukaryotes) and multicellular organisms (like us) both have the basic unit of life, the cell.