The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans).
Connective tissue disease. A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
The connective tissue holds bones, ligaments, and muscles together. Collagen vascular disease is sometimes also called connective tissue disease. Some disorders classified as collagen vascular diseases affect your joints, skin, blood vessels, or other vital organs. Symptoms vary according to the specific disease.Examples of collagen vascular disease include: 1  lupus. 2  rheumatoid arthritis.3  scleroderma. 4  temporal arteritis.eople with collagen vascular disorders typically experience: 1  fatigue. 2  muscle weakness. 3  fever. 4  body aches. 5  joint pain. 6  skin rash.