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100% activity is attained after 24 hours. It is also described therein that, 6 hours after oral administration to cats, nitenpyram reaches an activity of 60% against the fleas present on the cats, and on the second day after renewed infestation it still gives 55% activity.
It depends on at least two factors. The first is how much you are given the Novocaine and the second is the location of the treatment. An injection of Novocaine normally lasts for one to two hours for the tooth. However, it might number your tongue, face, and lips up to five hours, or three hours at least.