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He said that results of this study suggest that there may be two separate ways the brain communicates with the spleen to regulate immune function. This points the way to a possible solution for treating sepsis. It may be more effective to take advantage of the central nervous system to control cells of the spleen.
Immune cells communicate in a number of ways, either by cell-to-cell contact or through secreted signaling molecules. Receptors and ligands are fundamental for cellular communication. Receptors are protein structures that may be expressed on the surface of a cell or in intracellular compartments.hey then communicate with each other using lipid and other secreted mediators to form cellular swarms.. Their coordinated movement and exchange of signals then instructs other innate immune cells called macrophages and monocytes (in green) to surround the neutrophil cluster and form a tight wound seal.