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100% activity is attained after 24 hours. It is also described therein that, 6 hours after oral administration to cats, nitenpyram reaches an activity of 60% against the fleas present on the cats, and on the second day after renewed infestation it still gives 55% activity.
A Cochrane review assessed the efficacy of pregabalin for chronic pain. The NNT for greater than 50% pain relief over baseline with 600 mg/day was 5.0 (95% CI 4.0â6.6) for painful diabetic neuropathy (six studies, 1360 patients) and 5.6 (95% CI 3.5â14) for central neuropathic pain (two studies, 176 patients).