The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans).
Connective tissue disease. A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
collagen disease, an abnormal condition characterized by extensive disruption of the connective tissue, often involving inflammation and fibrinoid degeneration. Collagen diseases include polyarteritis nodosa, systemic lupus erythematosus, osteoarthritis, and rheumatoid arthritis.ollagen disease. n. Any of a group of inflammatory, often autoimmune diseases affecting connective tissue, including lupus erythematosus, rheumatoid arthritis, polyarteritis nodosa, scleroderma and dermatomyositis. Also called collagenosis, collagen vascular disease.