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Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with varicella zoster virus (VZV).The disease results in a characteristic skin rash that forms small, itchy blisters, which eventually scab over.hickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with varicella zoster virus (VZV).
1 Chickenpox (varicella) is a viral illness caused by the herpes zoster virus (also known as the Varicella-Zoster virus) 2  In children it usually causes a relatively mild illness.  Chickenpox in adults and immunosuppressed people can be severe.