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Pork loin should be cooked for approximately 30 minutes per pound in an oven that has been preheated to 350 degrees. A good way to ensure that a pork loin is properly cooked is to use a meat thermometer. The meat will be done when the thermometer reaches a temperature of 155 to 165 degrees. Continue Reading.
Best Answer: For your seasoned pork loin, preheat your oven to 400 degrees F or (200C). Place the seasoned pork in the preheated oven and immediately turn the oven down to 350F (175C). Roast the pork loin or tenderloin for about 70-90 minutes or until it reaches an internal temperature of 145-150F (73-75C) degrees. If you prefer your pork cooked to medium well, cook it to an internal temperature of 155-160F (78-80C) degrees.