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100% activity is attained after 24 hours. It is also described therein that, 6 hours after oral administration to cats, nitenpyram reaches an activity of 60% against the fleas present on the cats, and on the second day after renewed infestation it still gives 55% activity.
Clinical studies (described below) examined the efficacy of NORTHERA in the short-term (1 to 2 weeks) and over longer-term periods (8 weeks; 3 months). Studies 301 and 306B showed a treatment effect of NORTHERA at Week 1, but none of the studies demonstrated continued efficacy beyond 2 weeks of treatment.