The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. The search textbox has an autosuggest feature.
Aldactone Description: Aldactone (spironolactone) is an antagonist of aldosterone and is pharmaceutically classified as a diuretic. It acts by competitively inhibiting aldosterone binding to receptor sites, especially in the renal tubes where aldosterone is involved in sodium-potassium exchange.
Spironolactone is a potassium-sparing diuretic. Sometimes called water pills, diuretics help the kidneys expel water and salt in urine while retaining potassium. The drug may also be used in combination with other medications to treat precocious (early) puberty and myasthenia gravis, a neuromuscular disease.