The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans).
Connective tissue disease. A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
When inflammatory, it is known as myelitis. Disease that is vascular in nature is known as vascular myelopathy. The most common form of myelopathy in human is caused by degenerative changes in the cervical spine, which cause chronic compression of the spinal cord.isease that is vascular in nature is known as vascular myelopathy. The most common form of myelopathy in human is caused by degenerative changes in the cervical spine, which cause chronic compression of the spinal cord.