The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans).
Connective tissue disease. A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
Vascular disease is a class of diseases of the blood vessels â the arteries and veins of the circulatory system of the body.It is a subgroup of cardiovascular disease. Disorders in this vast network of blood vessels, can cause a range of health problems which can be severe or prove fatal. Buerger's disease â is due to small blood vessels that inflame and swell, vessels then narrow or are blocked by blood clots. 2  Raynaud's disease â a rare disorder of constriction of the peripheral blood vessels, in the fingers and toes when the person is cold.