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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
1 Aspirin often is prescribed in moderate doses (160-325 mg/day) for patients who are having heart attacks to limit the extent of damage to the heart's muscle (by preventing blood clot formation in the blood vessels of the heart), prevent additional heart attacks, and improve survival. Aspirin often is prescribed in low doses (75-160 mg/day) on a long-term basis to patients with prior heart attacks or strokes and to patients with TIAs (transient ischemic attacks or mini-strokes) and exertional angina to prevent heart attacks and ischemic strokes.