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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
If you don't have heart disease, the answer is more complex. Don't take aspirin if you are below 45, and think twice about it if you are 79 or older. If you are between 45 and 79, you should consider taking 81 mg of aspirin a day if your risk of heart attack exceeds your risk of aspirin-induced bleeding.