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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Low-dose aspirin (81 mg) is the most common dose used to prevent a heart attack or a stroke. But the dose for daily aspirin can range from 81 mg to 325 mg.One low-dose aspirin contains 81 mg. One adult-strength aspirin contains about 325 mg. For low-dose aspirin therapy, do not take medicines that combine aspirin with other ingredients such as caffeine and sodium.our doctor has probably already prescribed low-dose aspirin for you. For people who have had a stroke: Aspirin can help prevent a second stroke or a transient ischemic attack (TIA) , which is often a warning sign of an impending stroke.