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Symptoms of mononucleosis generally resemble those of the flu and include fever, sore throat, and swollen lymph glands. Sometimes, a swollen spleen or liver involvement may develop. These symptoms usually last for more than two days and may appear slowly.
Swollen glands of the neck are especially typical of mono. Most people develop a sore throat, which can be very severe, with inflamed tonsils. A fever -- usually no higher than 104 degrees -- also can develop and may last up to three weeks.ther major complications that can develop from mono include rupturing of the spleen, low blood platelet count, swelling of the lining of the brain or spinal cord, or inflammation of the brain itself.