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Symptoms of mononucleosis generally resemble those of the flu and include fever, sore throat, and swollen lymph glands. Sometimes, a swollen spleen or liver involvement may develop. These symptoms usually last for more than two days and may appear slowly.
It is typically the severe sore throat that prompts people to contact their doctor. In addition to a fever from 102 F-104 F, the most common signs of mono are. 1  a very reddened throat and tonsils and.  swollen lymph nodes in the neck that typically occur on both sides.