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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
The recommended aspirin dosage for adults varies according to the disease being treated. For adults, to relieve the pain or reduce the fever, the indicated dose of aspirin is between 325 mg and 650 mg every 4-6 hours. The maximum dose per day is 4000 mg, unless you have other recommendations from your doctor. 1  To treat inflammation caused by rheumatoid arthritis, the recommended dose for adults is 975 mg, 4-6 times a day at regular intervals. For treating pains of migraine, the indicated dosage of aspirin for adults is 1000 mg, at the first appearance of pain or symptoms.