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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
You may use aspirin to help treat minor pain. To treat pain, a typical treatment with aspirin is four to eight 81-mg tablets every four hours or one to two 325-mg tablets every four hours. You should never take more than 48 81-mg tablets or 12 325-mg tablets in 24 hours. Your doctor may also prescribe aspirin to help prevent heart attack or stroke.