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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise.