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For ALL, chemotherapy may be given into the fluid surrounding the brain and spinal cord. This is called intrathecal chemotherapy.
Several factors related to intrathecal preparation can affect toxicity. Thus, it was decided to standardize intrathecal chemotherapy, trying to obtain the best toxicity profile. Objective To assess the toxicity of a standardized triple intrathecal chemotherapy in oncohematological pediatric patients and to establish risk factors of toxicity.