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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
What is the typical recommended dosage of aspirin for an adult? To treat pain, the typical recommended dosage of aspirin for an adult is 325 to 650 milligrams every four hours, according to Drugs.com. No more than 4 grams of aspirin should be taken in 24 hours. The same dosage is used to lower fevers.