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The two are often believed to be interchangeable, but the main difference is that retinol is eventually converted into retinoic acid. Retinol is a natural form of vitamin A, while Retin-A is derived from retinoic acid, a synthetic derivative of vitamin A, and considered pharmaceutical.
Thanks for such a great question! In truth, you will get similar results with Retin-A and Retin-A Micro, unless you have oily skin, in which case Retin-A Micro will reduce shine significantly more. The main difference between Retin-A and Retin-A Micro is the following: 1  Retin-A: A cream with a given concentration of tretinoin.