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Ketamine (Ketalar) is a dissociative general anesthetic that has been available by prescription in the U.S. since the 1970s for human and veterinary uses. It has also been used for pain control in burn therapy, battlefield injuries, and in children who cannot use other anesthetics due to side effects or allergies.
Pharmacologically, ketamine is classified as an NMDA receptor antagonist, but it also acts at numerous other sites (including opioid receptors and monoamine transporters). Like other drugs of the arylcyclohexylamine class, such as phencyclidine (PCP), ketamine is classified as a dissociative agent.ow-dose ketamine is sometimes used in the treatment of complex regional pain syndrome (CRPS). A 2013 systematic review found only low-quality evidence to support the use of ketamine for CRPS.