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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Take the Right Amount. For people facing a high risk of getting a heart attack, a low-dose aspirin (81 mg per day) lowers your chances. One baby aspirin each day is probably all you need. But even at the lowest doses, the blood-thinning effects of the medicine can cause bleeding in your stomach. 1 | 2 | 3.