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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
edit Recommended Dosage of ibuprofen and aspirin. The adult dose for ibuprofen is between 200mg and 800mg per dose, up to four times a day. A doctor should be consulted in the case of an overdose. The adult dose for aspirin is typically 325mg, which can be taken four times a day.