It became clear that, in order to fully implement the intent of the streamlining initiative, CSAVR, its member state agencies, and RSA needed to agree on some fundamental changes in policy and practice. To accomplish its goal, the RSA provides its members with leadership and service.
Methadone was introduced into the United States in 1947 by Eli Lilly and Company as an analgesic under the trade name Dolophine, which is now registered to Roxane Laboratories. Since then, it has been best known for its use in treating opioid dependence.
Methadoneâenantiomers, quantitation in humans using stable isotope labeling; Enantiomersâof methadone, quantitation in humans using stable isotope labeling; Narcoticsâmethadone, quantitation of enantiomers in humans using stable isotope labeling Abstract A new technique for simultaneous stereoselective kinetic studies of methadone enantiomers was developed using three deuterium-labeled forms of methadone and GLC-chemical-ionization mass spectrometry. A racemic mixture (1:1) of (R)-(-)-[2 H 5]methadone (l-form) and (S)-(+)-[2 H 3]methadone (d-form) was administered orally in place of a single daily dose of unlabeled (Â±)-[2 H 8]methadone in longterm maintenance patients.