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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Should you take an aspirin a day? Taking low-dose aspirin (81 milligrams or baby aspirin) can help ward off stroke for some women 65 and older and heart attack for men 45 to 79. But if you take aspirin, skip ibuprofen for pain relief. The combo might lead to stomach bleeding and ulcers.