Make sure that your cuts are as accurate as possible. If you need to trim areas, you can simply run the knife along the edge. Hold the knife so that the blade bites slightly into the edge. This can be a tedious process so try to get it right the first time.
When insulin binds to the receptor, it is thought to cause a change in shape that is propagated inside the cell, activating the tyrosine kinases. The details are still a mystery and an area of active research.
What happens when insulin production and secretion fails? How does the body react to a collapse of the insulin signalling system? This can follow either destruction of Islet beta cells (diabetes type 1) or loss of response to insulin (diabetes type 2/insulin resistance).