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Symptoms of mononucleosis generally resemble those of the flu and include fever, sore throat, and swollen lymph glands. Sometimes, a swollen spleen or liver involvement may develop. These symptoms usually last for more than two days and may appear slowly.
Mono needs to run its course naturally. Symptoms may last 2 to 4 weeks, and some people feel tired for several weeks longer (that's why it's important to take care of yourself and get lots of rest). Doctors and researchers aren't exactly sure how long people with mono stay contagious after symptoms are gone. They believe that people can spread the infection for many months after their symptoms are completely gone â some studies show as long as 18 months.