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Hubble is the only telescope designed to be serviced in space by astronauts. After launch by Space Shuttle Discovery in 1990, four subsequent Space Shuttle missions repaired, upgraded, and replaced systems on the telescope. A fifth mission was canceled on safety grounds following the Columbia disaster (2003).
Putting a telescope in space is one way of evading this problem. As well as collecting visible light from its orbit high above the atmosphere, the Hubble Space Telescope also observes the infrared and ultraviolet wavelengths that are completely filtered out by the atmosphere.