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For ALL, chemotherapy may be given into the fluid surrounding the brain and spinal cord. This is called intrathecal chemotherapy.
Chemotherapy drugs in the bloodstream canât reach the brain and spinal cord. To treat these parts of the body the drugs need to be injected directly into the cerebrospinal fluid. This is done through a lumbar puncture. Giving chemotherapy in this way is called intrathecal chemotherapy. You will have intrathecal chemotherapy even if leukaemia cells canât be detected in the CSF. This is because research has shown that there is a high risk of leukaemia cells in the CSF.