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Symptoms of mononucleosis generally resemble those of the flu and include fever, sore throat, and swollen lymph glands. Sometimes, a swollen spleen or liver involvement may develop. These symptoms usually last for more than two days and may appear slowly.
Checking for Symptoms. 1  1. Watch for flu-like symptoms. When the symptoms first occur, you may feel like you have a cold or the flu. 2  2. Take your temperature. With EBV or mono, you might run a fever of about 102Â°F or 39Â°C. 3  3. Try swallowing. Both pain when you swallow and a sore throat that lasts for over two weeks are typical of the virus and mono.