This means that Hairy cell leukemia, or a subtype of Hairy cell leukemia, affects less than 200,000 people in the US population. Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Hairy cell leukemia as a rare disease.
In fact, some of the oldest alphabetic symbols have been found in Central America (2,500 years ago), China (more than 3,000 years ago), and the Middle East (more than 5,000 years ago). One of the earliest forms of the alphabet was hieroglyphics. Hieroglyphics were single symbols that stood for entire words.
However, even up to the 20th century, runes were used for traditional and decorative purposes. Over time, the alphabet transformed and evolved. Elder Futhark is the oldest alphabet, used from the 2nd to the 8th century. Anglo-Frisian runes (also known as Anglo-Saxon runes) were used from the 5th to the 11th century.