The half-life of the ketorolac tromethamine S-enantiomer was approximately 2.5 hours (SD Â± 0.4) compared with 5 hours (SD Â± 1.7) for the R-enantiomer. In other studies, the half-life for the racemate has been reported to lie within the range of 5 to 6 hours.
Proton pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. Within the class of medications, there is no clear evidence that one agent works better than another. They are the most potent inhibitors of acid secretion available.
Why It Is Used. Proton pump inhibitors are usually used: 1  To prevent GERD symptoms. 2  To heal inflammation of the esophagus (esophagitis). 3  To prevent esophagitis from coming back after the esophagus is healed (maintenance therapy) and to prevent complications of gastroesophageal reflux disease (GERD).hat To Think About. Proton pump inhibitors work best when they are taken 30 minutes before your first meal (for example, breakfast). If taking one pill before breakfast does not completely relieve your symptoms, talk to your doctor about taking another pill before dinner.