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Symptoms of mononucleosis generally resemble those of the flu and include fever, sore throat, and swollen lymph glands. Sometimes, a swollen spleen or liver involvement may develop. These symptoms usually last for more than two days and may appear slowly.
Symptoms of Mononucleosis: Introduction. Symptoms of mononucleosis can vary among individuals but generally begin about four to six weeks after exposure to the disease. Early symptoms are flu-like and may include fever, severe fatigue, headache, sore throat, and swollen tonsils. As mononucleosis progresses, typical symptoms include painful swollen glands in the neck, armpits, or groin. Some people may also develop a rash. Mononucleosis can also affect the spleen and result in an enlarged spleen, possibly leading to the critical, life-threatening complication of ruptured spleen.