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Continued use of lithium can lead to more serious kidney damage, aggravated form of diabetes insipidus. and chronic kidney failure. Chronic kidney disease is found in about one-third of people undergoing long-term lithium treatment, according to one study.
The dose of lithium varies among individuals and as phases of their illness change. Although bipolar disorder is often treated with more than one drug, some people can control their condition with lithium alone. Lithium Side Effects. About 75% of people who take lithium for bipolar disorder have some side effects, although they may be minor. They may become less troublesome after a few weeks as your body adjusts to the drug. Sometimes, side effects of lithium can be relieved by tweaking the dose.