States with the highest per student expenditures were: 1  Vermont ($19,752), 2  New York ($19,523), 3  New Jersey ($19,291), 4  Alaska ($18,192),and. 5  Rhode Island ($17,666).
1 Glucagon binds its receptor in the plasma membrane of target cells (e.g. hepatocytes). 2  Bound receptor interacts with and, through a set of G proteins, turns on adenylate cyclase, which is also an integral membrane protein.
After the intracellular signal that resulted from the binding of insulin to its receptor has been produced, termination of signaling is then needed. As mentioned below in the section on degradation, endocytosis and degradation of the receptor bound to insulin is a main mechanism to end signaling.