Make sure that your cuts are as accurate as possible. If you need to trim areas, you can simply run the knife along the edge. Hold the knife so that the blade bites slightly into the edge. This can be a tedious process so try to get it right the first time.
When insulin binds to the receptor, it is thought to cause a change in shape that is propagated inside the cell, activating the tyrosine kinases. The details are still a mystery and an area of active research.
1 In this case, the estrogen hormone 17-beta-estradiol is the ligand, and the estrogen receptor is the protein.  Binding turns on, or activates, a hormone receptor. Activation sets in motion cell signaling systems that trigger gene expression and lead to responses typical of a particular hormone.