Make sure that your cuts are as accurate as possible. If you need to trim areas, you can simply run the knife along the edge. Hold the knife so that the blade bites slightly into the edge. This can be a tedious process so try to get it right the first time.
When insulin binds to the receptor, it is thought to cause a change in shape that is propagated inside the cell, activating the tyrosine kinases. The details are still a mystery and an area of active research.
When insulin binds to the insulin receptor, it leads to a cascade of cellular processes that promote the usage or, in some cases, the storage of glucose in the cell. The effects of insulin vary depending on the tissue involved, e.g., insulin is most important in the uptake of glucose by muscle and adipose tissue. This insulin signal transduction pathway is composed of trigger mechanisms (e.g., autophosphorylation mechanisms) that serve as signals throughout the cell.