Acute Hepatic Failure in Dogs. Acute hepatic failure is a condition characterized by the sudden loss of 70 percent or more of the liver's function due to sudden, massive, hepatic necrosis (tissue death in the liver).
Key Points. Secondary (acquired) immunodeficiencies are much more common than primary (hereditary) immunodeficiencies. Primary immunodeficiencies can affect humoral immunity (most commonly), cellular immunity, both humoral and cellular immunity, phagocytic cells, or the complement system.
More than 100 of these disorders have been described, and heterogeneity within each disorder may be considerable. The molecular basis for about 80% is known. Primary immunodeficiencies typically manifest during infancy and childhood as abnormally frequent (recurrent) or unusual infections. About 70% of patients are 20 yr at onset; because transmission is often X-linked, 60% are male. Overall incidence of symptomatic disease is about 1/280 people.