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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
The U.S. Preventive Services Task Force recommends that men 45 to 79 take aspirin every day when the risk of a heart attack outweighs the risk of stomach bleeding. Same goes for women ages 55 to 79. Your doctor will know which risk is greater based on your health history.