Moving toward continuous production with SIMATIC SIPAT. The technological basis for continuous manufacturing is the use of Process Analytical Technology (PAT). Previously, it was virtually impossible to determine the clinical efficacy of an active ingredient online.
Benzene is a component of products derived from coal and petroleum and is found in gasoline and other fuels. Benzene is used in the manufacture of plastics, detergents, pesticides, and other chemicals. With exposures from less than five years to more than 30 years, individuals have developed, and died from, leukemia. Long-term exposure may affect bone marrow and blood production. Short-term exposure to high levels of benzene can cause drowsiness, dizziness, unconsciousness, and death.
The symptoms of cyanide exposure are seen rapidly, and include headaches, nausea, vomiting, and elevated breathing and heart rates. With a suitable dose, these symptoms can quickly progress to loss of consciousness, respiratory failure, and death. The exact dose that causes death depends on the form of cyanide administered, but lethal doses as low as one milligram per kilogram of body weight have been reported.