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Bone replaces cartilage here in the same way as it does in the primary centers. However, cartilage remains in two places: (1) on the articular surfaces of joints, and (2) as a transverse epiphyseal plate between the epiphyses and diaphysis. After adult stature is reached, the epiphyseal plate is replaced by bone.
1 Interstitial growth-Chondroblasts within the existing cartilage divide and form small groups of cells, isogenous groups, which produce matrix to become separated from each other by a thin partition of matrix. 2  Interstitial growth occurs mainly in immature cartilage.