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The two are often believed to be interchangeable, but the main difference is that retinol is eventually converted into retinoic acid. Retinol is a natural form of vitamin A, while Retin-A is derived from retinoic acid, a synthetic derivative of vitamin A, and considered pharmaceutical.
â The vitamin A from animal sources is retinoids, also called retinol, while plant source vitamin A is carotenoids, such as beta carotene. Animal sources of retinol is bio-available, which means the body can utilize it.he most important fact about vitamin A is the difference between retinoids and cartenoids. The vitamin A from animal sources is retinoids, also called retinol, while plant source vitamin A is carotenoids, such as beta carotene. Animal sources of retinol is bio-available, which means the body can utilize it.