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Symptoms of mononucleosis generally resemble those of the flu and include fever, sore throat, and swollen lymph glands. Sometimes, a swollen spleen or liver involvement may develop. These symptoms usually last for more than two days and may appear slowly.
Classic mono usually begins with 2 to 5 days of feeling tired and under the weather, sometimes with a fever. This may even last a week or two. Then a sore throat develops with swollen glands in the neck and elsewhere. Fever and tiredness increase.