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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Your doctor will discuss what dose is right for you. Very low doses of aspirin â75 milligrams (mg), which is less than a standard baby aspirin â can be effective.Your doctor will usually prescribe a daily dose anywhere from 81 mg â the amount in a baby aspirin â to 325 mg (a regular strength tablet).If you have had a heart attack or have had a heart stent placed, it's very important to take aspirin and any other blood-thinning medications exactly as recommended.he benefit of daily aspirin therapy doesn't outweigh the risk of bleeding in people with a low risk of heart attacks. The higher your risk of heart attack, the more likely it is that the benefits of daily aspirin outweigh the risk of bleeding.