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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Aspirin low-dose is a reduced dosage version of regular strength aspirin. Regular strength aspirin is 325 mg. Aspirin low-dose is below 100 mg., typically 81 mg. If you need aspirin for pain relief or treating a fever, you should take the regular strength, unless recommended otherwise by your doctor. Aspirin low-dose is taken on a daily basis to reduce the risk of heart attack and stroke. You should not take regular dose aspirin on a long-term, regular basis because of the risk of serious side effects from chronic use.