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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Some adults take aspirin every day under doctor's supervision. The usual dose to help prevent heart attacks ranges from 81 to 325 milligrams, states Mayo Clinic. Adult patients with arthritis often take 3 grams of aspirin divided into multiple doses, Drugs.com says. A daily dose of 75 to 325 milligrams is sometimes used to prevent a stroke. If an adult has already had a stroke, 50 to 325 milligrams of aspirin is prescribed. Learn more about Medications & Vitamins