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For ALL, chemotherapy may be given into the fluid surrounding the brain and spinal cord. This is called intrathecal chemotherapy.
Matloub Y, Lindemulder S, Gaynon PS, Sather H, La M, Broxson E, et al. Intrathecal triple therapy decreases central nervous system relapse but fails to improve event free survival when compared with intrathecal methotrexate: results of the Childrenâs Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Childrenâs Oncology Group.