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Symptoms of mononucleosis generally resemble those of the flu and include fever, sore throat, and swollen lymph glands. Sometimes, a swollen spleen or liver involvement may develop. These symptoms usually last for more than two days and may appear slowly.
The more classic symptoms of mono then follow and include: 1  a severe sore throat, with tonsils that are red, enlarged and covered in pus. 2  swollen glands (lymphadenopathy) in the neck. 3  fever, which can be as high as 104 F to 105 F and may last one to two weeks.  continued malaise and fatigue, which can be extreme.