In 2010, the FDA approved Botox as a treatment for chronic migraine. Get more information about how and why it can help with this migraine subtype. In 2010, the FDA approved Botox as a treatment for chronic migraine.
In modern lithography, the image is made of a polymer coating applied to a flexible aluminum plate. The image can be printed directly from the plate (the orientation of the image is reversed), or it can be offset, by transferring the image onto a flexible sheet (rubber) for printing and publication.
Gravure, or intaglio, uses an etched metal plate (lithographic plates are flat) to hold the ink, which is then impressed into the paper. You can tell the difference between gravure printing and offset printing with a hand magnifier and a little practice.