Concept 19 The DNA molecule is shaped like a twisted ladder. Earlier work had shown that DNA is composed of building blocks called nucleotides consisting of a deoxyribose sugar, a phosphate group, and one of four nitrogen bases â adenine (A), thymine (T), guanine (G), and cytosine (C).-ray crystallography provided the final clue that the DNA molecule is a double helix, shaped like a twisted ladder. In 1953, the race to determine how these pieces fit together in a three-dimensional structure was won by James Watson and Francis Crick at the Cavendish Laboratory in Cambridge, England.
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