The half-life of the ketorolac tromethamine S-enantiomer was approximately 2.5 hours (SD Â± 0.4) compared with 5 hours (SD Â± 1.7) for the R-enantiomer. In other studies, the half-life for the racemate has been reported to lie within the range of 5 to 6 hours.
Proton pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. Within the class of medications, there is no clear evidence that one agent works better than another. They are the most potent inhibitors of acid secretion available.
Proton pump inhibitors. These drugs are potent inhibitors of H+,K+-ATPase. This enzyme, located in the apical secretory membrane of the parietal cell, plays a key role in the secretion of H+ (protons). These drugs can completely inhibit acid secretion and have a long duration of action.