The half-life of the ketorolac tromethamine S-enantiomer was approximately 2.5 hours (SD Â± 0.4) compared with 5 hours (SD Â± 1.7) for the R-enantiomer. In other studies, the half-life for the racemate has been reported to lie within the range of 5 to 6 hours.
Proton pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. Within the class of medications, there is no clear evidence that one agent works better than another. They are the most potent inhibitors of acid secretion available.
Introduction Proton pump inhibitors (PPI), the most potent inhibitors of gastric acid secretion, have revolutionized the treatment of acid-related disorders, including gastroesophageal reï¬ ux disease, peptic ulcer disease, and gastropathy induced by nonsteroidal anti-inï¬ ammatory drugs (NSAIDs).