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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Baby Aspirin May Be Best for Heart. May 8, 2007 -- Baby aspirin may be the best aspirin dose for heart health, according to a new research review. A single pill of baby aspirin contains 81 milligrams of aspirin. That's about a quarter of the 325-milligram dose in an adult aspirin pill. The new research review states that in the U.S., the most commonly prescribed aspirin dose for heart health is 81 milligrams per day. The review shows that aspirin doses greater than 81 milligrams per day haven't been proven better than baby aspirin for the heart and may increase the chances of stomach bleeding.