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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Answer: There is not a simple answer to your question. The amount of aspirin one person can take in a day varies depending on what a person is taking the aspirin for. For example, a person with rheumatoid arthritis may take up to 6 grams (~18 325 mg tablets) a day, whereas someone using it for a healthy heart will only take 81 mg of aspirin a day.