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Heat oven to 350 degrees. Place roast in casserole with ... onion soup over meat. Bake covered 2 to 2 1/2 hours, add vegetables. Cover and bake another hour.eat oven to 350 degrees. Place roast in casserole with ... onion soup over meat. Bake covered 2 to 2 1/2 hours, add vegetables. Cover and bake another hour.
Here's how you do it: 1  Cook the beef at 350F until its internal temperature reads 5-10 degrees below the desired doneness. 2  It'll take anywhere from 15 to 30 minutes per pound, depending on the shape of the roast, and how well done you like it. 3  Remove the roast from the oven, and let it stand for 20 minutes. This can take 4 to 8 hours depending on the size of the roast, and how cooked you like it. 2  Turn the heat up to 500F and cook it until it reaches 5 to 10 degrees below the desired doneness. 3  It shouldn't take much more than 10-15 minutes. 4  Remove the roast from the oven and let it stand about 20 minutes.