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Osmolality of blood increases with dehydration and decreases with overhydration. In normal people, increased osmolarity in the blood will stimulate secretion of antidiuretic hormone (ADH). This will result in increased water reabsorption, more concentrated urine, and less concentrated blood plasma.
The serum or plasma osmolality is a measure of the different solutes in plasma. Among other applications, serum osmolality is indicated to evaluate the etiology of hyponatremia and may be used to screen for alcohol intoxication by means of the osmolal gap. The reference range of serum osmolality is 275â295 mosm/kg (mmol/kg).