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The two are often believed to be interchangeable, but the main difference is that retinol is eventually converted into retinoic acid. Retinol is a natural form of vitamin A, while Retin-A is derived from retinoic acid, a synthetic derivative of vitamin A, and considered pharmaceutical.
Share with Friends: Tweet. Retinol is a form of Vitamin A that's usable by the body. Retinol is fat-soluble and found in animal-based foods. Retinol plays a role both as an antioxidant and as a wrinkle reducer in many anti aging skin care products and wrinkle creams.etinol has been observed to reduce the size of wrinkles. Fortunately, retinol is nowhere near as irritating to the skin as Retin-A. Thus, persons whose skin is too sensitive to make use of Retin-A may seek out products containing retinol as an effective alternative.