Leaf spot first appears in rainy or humid weather as the plants are growing. They look like small brown spots with a water-soaked margin surrounded by a yellow halo usually on the upper halves of the iris leaves.
Two, caffeine enhances the sensation and contractility of the bladder. Another way caffeine can affect prostate health is through its ability to irritate the bladder because it is a theoxanthine, a family of drugs that includes theobromine (found in chocolate) and theophylline (found in tea). Theophylline also stimulates and irritates the bladder.
Coffee-drinking smokers, on the other hand, were only three times more at risk. Coffee thus appears to somehow dilute the harmful effect of tobacco use on the bladder. Previous studies have suggested that caffeine might discourage mutations from forming, perhaps by inducing activity in an enzyme known as CYP1A2.