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Bone replaces cartilage here in the same way as it does in the primary centers. However, cartilage remains in two places: (1) on the articular surfaces of joints, and (2) as a transverse epiphyseal plate between the epiphyses and diaphysis. After adult stature is reached, the epiphyseal plate is replaced by bone.
Primary osteoarthritis is mostly related to aging. With aging, the water content of the cartilage increases and the protein makeup of cartilage degenerates. Repetitive use of the joints over the years causes damage to the cartilage that leads to joint pain and swelling. Eventually, cartilage begins to degenerate by flaking or forming tiny crevasses. In advanced cases, there is a total loss of the cartilage cushion between the bones of the joints. Loss of cartilage cushion causes friction between the bones, leading to pain and limitation of joint mobility. Damage to the cartilage can also stimulate new bone outgrowths (spurs) to form around the joints.