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Osmolality of blood increases with dehydration and decreases with overhydration. In normal people, increased osmolarity in the blood will stimulate secretion of antidiuretic hormone (ADH). This will result in increased water reabsorption, more concentrated urine, and less concentrated blood plasma.
The normal range of serum osmolality is 285-295 mOsm/kg. The measured osmolality should not exceed the predicted by more than 10 mOsm/kg.A difference of more than 10 mOsm/kg is considered an osmolal gap.Osm/kg. The normal range of serum osmolality is 285-295 mOsm/kg. The measured osmolality should not exceed the predicted by more than 10 mOsm/kg. A difference of more than 10 mOsm/kg is considered an osmolal gap.