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Bone replaces cartilage here in the same way as it does in the primary centers. However, cartilage remains in two places: (1) on the articular surfaces of joints, and (2) as a transverse epiphyseal plate between the epiphyses and diaphysis. After adult stature is reached, the epiphyseal plate is replaced by bone.
Intramembraneous ossification starts in connective tissue from mesenchymal cells that become osteoblasts. These osteoblasts cluster togehter into an ossification center. Endochondral ossification starts with a hyaline cartilage template. Mesenchymal cells become osteoblasts and begin forming bone around the cartilage.