Although the same diameter, the Mark 14 was longer, at 20 ft 6 in (6.25 m), and therefore incompatible with older submarines' 15 ft 3 in (4.65 m) torpedo tubes. The Mark 14 was designed at the Naval Torpedo Station (NTS), Newport, beginning in 1922. It had a fairly small warhead and was intended to explode beneath the keel where there was no armor.
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The innate immune response is not completely nonspecific, as was originally thought, but rather is able to discriminate between self and a variety of pathogens. The innate immune system recognizes microorganisms via a limited number of germline-encoded pattern-recognition receptors (PRRs). This is in contrast to the large repertoire of rearranged receptors utilized by the acquired system. PRRs possess common characteristics.