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Symptoms of mononucleosis generally resemble those of the flu and include fever, sore throat, and swollen lymph glands. Sometimes, a swollen spleen or liver involvement may develop. These symptoms usually last for more than two days and may appear slowly.
Usually mono is a mild illness that goes away without treatment after several weeks. When you have mono, your symptoms may come and go, and your symptoms may change with time. 1  A sore throat is worst during the first 3 to 5 days and gradually improves over the next 7 to 10 days. 2  Fever may last 10 to 14 days.3  Usually it is mild during the last 5 to 7 days.sually only self-care is needed for mono. 1  Get plenty of rest. 2  Gargle with salt water or use throat lozenges to soothe your sore throat. 3  Take acetaminophen (such as Tylenol) or ibuprofen (such as Advil) to reduce fever and relieve a sore throat and headaches. 4  Avoid contact sports and heavy lifting.