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Continued use of lithium can lead to more serious kidney damage, aggravated form of diabetes insipidus. and chronic kidney failure. Chronic kidney disease is found in about one-third of people undergoing long-term lithium treatment, according to one study.
Little Sign of Higher Kidney Risk With Long-term Lithium. Patients with affective disorders who begin treatment with lithium can be reassured that long-term, stable maintenance therapy with the drug does not lead to kidney damage, with neither the duration of use nor cumulative dose having an impact, say UK investigators.