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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
In the US the doses most frequently recommended are 80 mg, 160 mg, or 325 mg per day. Because aspirin can cause major bleeding the appropriate dose is the lowest dose that is effective in preventing both MI and stroke because these two diseases frequently co-exist.spirin for heart attack prevention My personal opinion is that aspirin, in a dosage of 81 mg 2 or 3 times a week, should provide enough benefits and at the same time minimize the risk for stomach ulcer or bleeding.