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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Very low doses of aspirin â75 milligrams (mg), which is less than a standard baby aspirin â can be effective. Your doctor will usually prescribe a daily dose anywhere from 81 mg â the amount in a baby aspirin â to 325 mg (a regular strength tablet).