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The initial cross between a serval and domestic cat is difficult due to the parents size and gestation period differences (65 days for domestics, up to 77 days for servals).
One difference is that animals that have estrous cycles reabsorb the endometrium if conception does not occur during that cycle. Animals that have menstrual cycles shed the endometrium through menstruation instead. Another difference is sexual activity. In species with estrous cycles, females are generally only sexually active during the estrus phase of their cycle (see below for an explanation of the different phases in an estrous cycle).