Make sure that your cuts are as accurate as possible. If you need to trim areas, you can simply run the knife along the edge. Hold the knife so that the blade bites slightly into the edge. This can be a tedious process so try to get it right the first time.
When insulin binds to the receptor, it is thought to cause a change in shape that is propagated inside the cell, activating the tyrosine kinases. The details are still a mystery and an area of active research.
bind to membrane receptors, are often used in paracrine and autocrine signaling. They generally modulate the effect of other hormones. Once a signaling molecule binds to its receptor it causes a conformational change in it that results in a cellular response. The same ligand can bind to different receptors causing different responses (e.g.. acetylcholine). On the other hand, different ligands binding to different receptors can produce the. same cellular response (e.g. glucagon, epinephrine).