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For ALL, chemotherapy may be given into the fluid surrounding the brain and spinal cord. This is called intrathecal chemotherapy.
Freebase(0.00 / 0 votes)Rate this definition: Intrathecal. Intrathecal is an adjective that refers to something introduced into or occurring in the space under the arachnoid membrane of the brain or spinal cord. For example, intrathecal immunoglobulin production means production of this substance in the spinal cord. Another way the word is used is to refer to an intrathecal injection.