Make sure that your cuts are as accurate as possible. If you need to trim areas, you can simply run the knife along the edge. Hold the knife so that the blade bites slightly into the edge. This can be a tedious process so try to get it right the first time.
When insulin binds to the receptor, it is thought to cause a change in shape that is propagated inside the cell, activating the tyrosine kinases. The details are still a mystery and an area of active research.
The pancreas then secretes insulin in response to the increase in blood sugar. Most cells of the body have insulin receptors which bind the insulin to the cell. When a cell has insulin attached to it, the cell then is able to activate the other receptors.