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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
5.0%. Mehta told heartwire that on the basis of these results, he is now recommending aspirin at a dose of 81 mg daily for secondary prevention, apart from in the acute situation and perhaps in the initial 4 weeks after a stent placement, where 325 mg would be preferable.