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However, general guidelines are as follows: 1  For a headache or muscle ache, take 325 mg of aspirin every 4-6 hours. 2  To prevent a heart attack, take two low-dose (81 mg) aspirin every day if youâre at risk or over 40.
Some were taking a regular low dose of aspirin â in the range of 75 to 160 milligrams â and others were not. A typical baby aspirin sold at pharmacies in the United States contains 80 milligrams of the drug, compared to 325 milligrams for a regular aspirin. After five years, women who had been taking a daily low-dose of aspirin scored higher on cognitive tests then their peers who werenât taking aspirin.