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The most common types of medicines that doctors use to treat acne include: 1  Benzoyl peroxide, such as Brevoxyl or Triaz. 2  Salicylic acid, such as Propa pH or Stridex. 3  Topical and oral antibiotics, such as clindamycin, doxycycline, erythromycin, and tetracycline.
Spironolactone is another possible prescription treatment measure for cystic acne. Traditionally, itâs used as a diuretic to help treat edema and high blood pressure. In terms of acne, this medication can work by managing excess androgen levels that could be contributing to inflammatory acne.