Even if we stopped all carbon dioxide emissions tomorrow, we'd still see some effects, Haq says. That, of course, is the bad news. But there's also good news. By aggressively reducing our global emissions now, we can avoid a lot of the severe consequences that climate change would otherwise bring, says Haq.
Lipophilicity is possibly the lost important physicochemical property of a potential drug, it plays a role in solubility, absorption, membrane penetration, plasma protein binding, distribution, CNS penetration and partitioning into other tissues or organs such as the liver and has an impact on the routes of clearance.owever the majority of known drugs contain ionisable groups and are likely to be charged at physiological pH and LogP only correctly describes the partition coefficient of neutral (uncharged) molecules. LogD the distribution constant is a better descriptor of the lipophilicity of a molecule.
Drug suspensions naturally allow prolonged delivery because of slow drug dissolution (Durairaj et al., 2009). However, it is unclear whether drug solubility and/or lipophilicity influence in vivo transscleral delivery of various corticosteroids from suspensions.Furthermore, it is not clear whether tissue partition coefficients and tissue permeability of corticosteroids can be correlated to in vivo transscleral delivery.or drugs in solution at low concentrations, a decrease in transscleral transport has been observed with increasing drug lipophilicity, as a result of drug binding and retention in melanin-rich choroid-retinal pigment epithelium (CRPE) layer or sclera (Cheruvu and Kompella, 2006; Cheruvu et al., 2008).