Even if we stopped all carbon dioxide emissions tomorrow, we'd still see some effects, Haq says. That, of course, is the bad news. But there's also good news. By aggressively reducing our global emissions now, we can avoid a lot of the severe consequences that climate change would otherwise bring, says Haq.
Lipophilicity is possibly the lost important physicochemical property of a potential drug, it plays a role in solubility, absorption, membrane penetration, plasma protein binding, distribution, CNS penetration and partitioning into other tissues or organs such as the liver and has an impact on the routes of clearance.owever the majority of known drugs contain ionisable groups and are likely to be charged at physiological pH and LogP only correctly describes the partition coefficient of neutral (uncharged) molecules. LogD the distribution constant is a better descriptor of the lipophilicity of a molecule.
1 FACTORS AFFECTING DRUG ABSORPTION List of content :-- I. PHARMACEUTICAL FACTORS A] Chemical factors B] Physicochemical properties of drug substances 1.drug solubility & dissolution rate 2.--Which increases the pH of the diffusion layer, which promotes the solubility and dissolution of a weak acid and absorption is bound to be rapid. ï· Reverse in the case of salts of weak bases, it lowers the pH of diffusion layer and the promoted the absorption of basic drugs.