Lyme disease is diagnosed clinically based on symptoms, objective physical findings (such as EM, facial palsy, or arthritis), or a history of possible exposure to infected ticks, as well as serological blood tests. The EM rash is not always a bull's eye, i.e., it can be solid red.
Rule of Thumb for Changing Filters. The rule we have followed for 18 years in the filtration industry is to change filters every 6 to 12 months. Six months is almost always optimum, especially in commercial/office settings, and twelve months is as long as you want to go no matter what.
To prevent bacteria build up, change the water frequently. A good rule of thumb is to change the water tank every two days per gallon of water. For example, change a one-gallon aquarium every two days, a two gallon aquarium every four days, etc. Stress. Betta fish can actually worry themselves to death.