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The duodenum is the first part of the small intestine. It is located between the stomach and the middle part of the small intestine, or jejunum. After foods mix with stomach acid, they move into the duodenum, where they mix with bile from the gallbladder and digestive juices from the pancreas.
The duodenum lies at the beginning of the small intestine. Together with the jejunum, and the ileum it forms the small intestine. It is connected to the stomach above and the jejunum below it. When food enters the duodenum, there are multiple feed-back pathways and nervous reflexes that will affect how fast the stomach empties as well as the secretion of other hormones.