Commercial Off-The-Shelf (COTS) Definition - What does Commercial Off-The-Shelf (COTS) mean? Commercial off-the-shelf (COTS) is a term that references non-developmental items (NDI) sold in the commercial marketplace and used or obtained through government contracts. The set of rules for COTS is defined by the Federal Acquisition Regulation (FAR).
Acromegaly is usually caused by a non-cancerous tumor in the pituitary gland called a pituitary adenoma. The tumor produces too much GH and raises the level of GH in the blood. Too much GH also raises the level of insulin-like growth factor-1 (IGF-1), a hormone produced in the liver that also promotes growth. Rarely, acromegaly is caused by hormone-producing tumors in other parts of the body.
The pituitary gland is about the size of a pea, and is located at the base of the brain. It controls the production of hormones in all endocrine glands. Acromegaly is a condition in which the pituitary gland secretes growth hormone after the normal growth of the skeleton and other organs is complete.In almost all cases, it is caused by a benign (non-cancerous) tumor of the pituitary gland.cromegaly is most often caused by a benign (non-cancerous) tumor of the pituitary gland that secretes excess growth hormone. In rare cases, acromegaly can be caused by tumors of the pancreas, lungs or adrenal glands.