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Translation: Taking expired doxycycline can harm your kidneys. While it is true that some drugs merely lose strength after their expiration date, many drugs (especially antibiotics!!) break down into harmful chemical products, similar to the way juice or wine can ferment if left too long. Bottom line--don't take them.
How long antibiotics stay in the body depends on several factors . The dose, the length of therapy, the drugs half life, renal and hepatic function and the individuals metabolism all contribute to the amount of time antibiotics last in the body.