Lyme disease is diagnosed clinically based on symptoms, objective physical findings (such as EM, facial palsy, or arthritis), or a history of possible exposure to infected ticks, as well as serological blood tests. The EM rash is not always a bull's eye, i.e., it can be solid red.
Rule of Thumb for Changing Filters. The rule we have followed for 18 years in the filtration industry is to change filters every 6 to 12 months. Six months is almost always optimum, especially in commercial/office settings, and twelve months is as long as you want to go no matter what.
The water should be changed every 20 to 30 minutes. Cold water thawing is much faster than thawing in the refrigerator (usually 8 to 10 times faster), but it can be annoying having to change the water every 30 minutes, especially when thawing a large turkey. At least 30 minutes defrosting time per pound should be allowed when using the cold water method.