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Causes of yellow eyes in children and adults. Yellow eyes, as well as yellowing of the skin, occur in children and adults when bilirubin builds up due to serious diseases and conditions that cause liver damage or dysfunction, or block the bile ducts.
An abnormal breakdown of red blood cells or the impaired excretion of bilirubin may also cause yellowing of the eyes. For this reason, conditions that affect the lifespan of red blood cells or their production can cause yellowing of the eyes. This includes: drug-induced immune hemolytic anemia.