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Angelman syndrome is a genetic disorder that affects the nervous system and causes severe physical and intellectual disability. It's relatively rare, occurring in around 1 in 16,000 people.Typical characteristics of Angelman syndrome include: 1  delayed development (usually noticeable from 6-12 months of age).n most cases of Angelman syndrome (about 70%), the child's maternal copy of the UBE3A gene is missing, which means there's no active copy of the UBE3A gene in the child's brain.
Improper imprinting can result in an individual having two active copies or two inactive copies. This can lead to severe developmental abnormalities, cancer, and other problems. Prader-Willi and Angelman syndrome are two very different disorders, but they are both linked to the same imprinted region of chromosome 15. Some of the genes in this region are silenced in the egg, and at least one gene is silenced in the sperm.