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Acute diarrhea causes may include: 1  Antacids containing magnesium. 2  Antibiotic-associated diarrhea. 3  Blood pressure medications. 4  C. difficile. 5  Campylobacter infection. 6  Cancer medications. 7  Clostridium perfringens infection.
The most common cause of acute diarrhea is infection--viral, bacterial, and parasitic. Bacteria also can cause acute food poisoning. A third important cause of acute diarrhea is starting a new medication.