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Angelman syndrome is a genetic disorder that affects the nervous system and causes severe physical and intellectual disability. It's relatively rare, occurring in around 1 in 16,000 people.Typical characteristics of Angelman syndrome include: 1  delayed development (usually noticeable from 6-12 months of age).n most cases of Angelman syndrome (about 70%), the child's maternal copy of the UBE3A gene is missing, which means there's no active copy of the UBE3A gene in the child's brain.
ADVERTISEMENT. 1  Angelman syndrome (AS) is a developmental disorder affecting the brain. 2  AS has been shown in most cases to have a genetic cause. 3  About 1 in 10 people with AS may have symptoms of AS but do not have a clear genetic cause. 4  AS occurs in approximately 1 out of 15,000 live births. 5  AS is generally found when a baby is between 6 and 12 ...