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By Mayo Clinic Staff. Hand numbness is usually caused by damage, irritation or compression of one of the nerves or a branch of one of the nerves in your arm and wrist. Diseases affecting the peripheral nerves, such as diabetes, also can cause numbness, although with diabetes similar symptoms usually occur first in your feet.
Definition. Numbness in one or both hands describes a loss of sensation or feeling in your hand or fingers. Often, numbness in hands may be accompanied by other changes, such as a pins-and-needles sensation, burning or tingling. The arm, hand or fingers may feel clumsy or weak.Numbness can occur along a single nerve, or it may occur in both hands in a symmetrical pattern. 1  Causes.ften, numbness in hands may be accompanied by other changes, such as a pins-and-needles sensation, burning or tingling. The arm, hand or fingers may feel clumsy or weak. Numbness can occur along a single nerve, or it may occur in both hands in a symmetrical pattern.