DEA 3.0 System: Dogs may have a DEA 3 system of blood type, if their blood has two antigens, DEA 3.0 and DEA Null. This is a rare type of blood and occurs in only in 5 â 6% of dogs. The most common breed with a DEA 3.0 positive type blood are grey hounds, in which 23% of all population is considered positive. If the dog is incompatible for this blood type and is transfused, erythrocytes or blood cells are usually replaced in 3 â 5 days, automatically.
Executive Summary. 1  The bloodâbrain barrier (BBB) is a significant obstacle to therapeutic delivery for CNS disorders. Among various strategies, nanobiotechnology plays an important role in facilitating drug delivery across the BBB. 2  Desirable characteristics of the ideal method of therapeutic delivery across the BBB are described in this article.
Functions of the BBB. The BBB has several important functions: 1  Protects the brain from foreign substances in the blood that may injure the brain. 2  Protects the brain from hormones and neurotransmitters in the rest of the body. Large molecules do not pass through the BBB easily. 2  Low lipid (fat) soluble molecules do not penetrate into the brain. 3  However, lipid soluble molecules, such as barbituate drugs, rapidly cross through into the brain. 4  Molecules that have a high electrical charge are slowed.