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By Mayo Clinic Staff. Hand numbness is usually caused by damage, irritation or compression of one of the nerves or a branch of one of the nerves in your arm and wrist. Diseases affecting the peripheral nerves, such as diabetes, also can cause numbness, although with diabetes similar symptoms usually occur first in your feet.
Numbness and tingling are unusual prickling sensations that can happen in any part of your body, but they are generally noticed in hands, feet, arms, and legs. Many things can cause the feeling of numbness and tingling, including sitting with your legs crossed or falling asleep on your arm.ther conditions that can cause numbness and tingling are: 1  insect or animal bites. 2  radiation therapy. 3  abnormal levels of vitamin B12 or other vitamins, potassium, calcium, or sodium. 4  seafood toxins. 5  carpal tunnel syndrome (pressure on the nerves in your wrist).