Long-term muscle use requires the delivery of oxygen and glucose to the muscle fiber to allow aerobic respiration to occur, producing the ATP required for muscle contraction. If the respiratory or circulatory system cannot keep up with demand, then energy will be generated by the much less efficient anaerobic respiration.
Then, Nicaragua, as well as Costa Rica, El Salvador, Guatemala and Honduras formed the United Provinces of Central America, but that federation quickly dissolved, and Nicaragua became an independent republic in 1838.
Although Nicaragua is the largest country in Central America it is the least densely populated. Nicaragua is bordered to the west by the Pacific Ocean and to the east by the Caribbean Sea. It shares a northern border along the Rio Coco of 530 kilometers with Honduras.