Commercial Off-The-Shelf (COTS) Definition - What does Commercial Off-The-Shelf (COTS) mean? Commercial off-the-shelf (COTS) is a term that references non-developmental items (NDI) sold in the commercial marketplace and used or obtained through government contracts. The set of rules for COTS is defined by the Federal Acquisition Regulation (FAR).
Acromegaly is usually caused by a non-cancerous tumor in the pituitary gland called a pituitary adenoma. The tumor produces too much GH and raises the level of GH in the blood. Too much GH also raises the level of insulin-like growth factor-1 (IGF-1), a hormone produced in the liver that also promotes growth. Rarely, acromegaly is caused by hormone-producing tumors in other parts of the body.
Acromegaly. Acromegaly is a condition caused by a benign tumor on the pituitary gland that results in the body's excessive production of growth hormone. Growth hormone is essential during puberty and is responsible for growth spurts. But after puberty, growth hormone production ordinarily drops to very low levels.n acromegaly, elevated growth hormone causes an abnormal increase in shoe and ring size, enlargement of the lower jaw bone and separation of teeth, and enlargement of the nose.