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The most common types of medicines that doctors use to treat acne include: 1  Benzoyl peroxide, such as Brevoxyl or Triaz. 2  Salicylic acid, such as Propa pH or Stridex. 3  Topical and oral antibiotics, such as clindamycin, doxycycline, erythromycin, and tetracycline.
Oral antibiotics are recommended for the treatment of moderate or severe inflammatory acne (papules, pustules, nodules, and cystic acne). They work by killing the acne causing skin bacteria Propionibacterium acnes and reducing inflammation.