Generalized anxiety disorder symptoms include: 1  Restlessness or feeling wound-up or on edge. 2  Being easily fatigued. 3  Difficulty concentrating or having their minds go blank. 4  Irritability. Muscle tension.  Difficulty controlling the 1  worry. Sleep problems (difficulty falling or staying asleep or restless, unsatisfying  sleep)
Protein Properties: Binding Sites [edit]. A binding site is a position on a protein that binds to an incoming molecule that is smaller in size comparatively, called ligand. In proteins, binding sites are small pockets on the tertiary structure where ligands bind to it using weak forces (non-covalent bonding).
The enzyme active site is the binding site for catalytic and inhibition reactions of enzyme and substrate; structure of active site and its chemical characteristic are of specific for the binding of a particular substrate.he three dimensional cleft is formed by the groups that come from different part of the amino acid sequences. The active site is only a small part of the total enzyme volume. It enhances the enzyme to bind to substrate and catalysis by many different weak interactions because of its nonpolar microenvironment.