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By Mayo Clinic Staff. Hand numbness is usually caused by damage, irritation or compression of one of the nerves or a branch of one of the nerves in your arm and wrist. Diseases affecting the peripheral nerves, such as diabetes, also can cause numbness, although with diabetes similar symptoms usually occur first in your feet.
Possible Causes of Numbness in Hands and Feet. 1. Multiple Sclerosis. Multiple sclerosis, or MS, is a type of autoimmune disease that affects the spinal cord and brain. It is due to damage of the myelin sheath, the protective covering around the nerve cells. In addition to numbness, other symptoms of MS include loss of balance, difficulty in moving the legs and arms, and muscle spasms. 2. Herniated Disc. Herniated discs may cause numbness in hands and feet as well as a tingling sensation. A herniated disc is when the cushioning between your discs or bones in the spine is pinched. The most common symptoms include numbness, pain or weakness in the lower back, an arm or a leg. 3. Vitamin B12 Deficiency