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About 45 people a day, more than 16,600 people a year, die from overdoses of the drugs, including methadone, morphine, and oxycodone (OxyContin) and hydrocodone combined with acetaminophen (Lortab and Vicodin). And for every death, more than 30 others are admitted to the emergency room.
Youâre actually more likely to die from taking just a little bit too much acetaminophen for several days or weeks than you are from taking a single large overdose. Acetaminophen is toxic to your liver, and is actually the number one cause of liver failure in the United States. Itâs surprisingly easy to take too much acetaminophen because itâs widely used in cold and flu and other over-the-counter medications, as well as in prescription painkillers like Vicodin and Percocet.