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Acute diarrhea causes may include: 1  Antacids containing magnesium. 2  Antibiotic-associated diarrhea. 3  Blood pressure medications. 4  C. difficile. 5  Campylobacter infection. 6  Cancer medications. 7  Clostridium perfringens infection.
Many medications, such as antibiotics, can cause diarrhea. Antibiotics destroy both good and bad bacteria, which can disturb the natural balance of bacteria in your intestines. Other drugs that cause diarrhea are cancer drugs and antacids with magnesium.