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Causes of yellow eyes in children and adults. Yellow eyes, as well as yellowing of the skin, occur in children and adults when bilirubin builds up due to serious diseases and conditions that cause liver damage or dysfunction, or block the bile ducts.
Besides liver dysfunction, other major causes of yellow eyes include a blockage to bile flow (i.e., gallstones) and increased breakdown of red blood cells. A commonly seen red blood cell disease that can give you yellow eyes is sickle cell anemia. These are only some of the many causes.