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Acute diarrhea causes may include: 1  Antacids containing magnesium. 2  Antibiotic-associated diarrhea. 3  Blood pressure medications. 4  C. difficile. 5  Campylobacter infection. 6  Cancer medications. 7  Clostridium perfringens infection.
Acute diarrhea usually has a bacterial or viral culprit. Gastroenteritis, mistakenly called the stomach flu, is one of the most common infections that cause diarrhea. Gastroenteritis can be caused by many different viruses. Eating or drinking foods contaminated with bacteria can also cause diarrhea. Other causes of acute diarrhea are lactose intolerance, sweeteners such as sorbitol, over-the-counter antacids that contain magnesium, too much vitamin C, and some antibiotics.