Generalized anxiety disorder symptoms include: 1  Restlessness or feeling wound-up or on edge. 2  Being easily fatigued. 3  Difficulty concentrating or having their minds go blank. 4  Irritability. Muscle tension.  Difficulty controlling the 1  worry. Sleep problems (difficulty falling or staying asleep or restless, unsatisfying  sleep)
Protein Properties: Binding Sites [edit]. A binding site is a position on a protein that binds to an incoming molecule that is smaller in size comparatively, called ligand. In proteins, binding sites are small pockets on the tertiary structure where ligands bind to it using weak forces (non-covalent bonding).
1 This binding to an allosteric site changes the conformation of the enzyme so that the affinity of the substrate for the active site is reduced. 2  These inhibitors lower the K m and V m. 3  File:Uncompetitive inhibition.docx. 4  mixed inhibition the inhibitors can bind to the enzyme at the same time as the enzyme substrate.