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They also carry out important functions in both the CNS and PNS. Schwann cells express the ERM proteins and merlin, but the absence of merlin alone results in NF2-related schwannomas, indicating that merlin has a distinct function in these cells. In neurons, the ERM proteins regulate key aspects of actin-dependent growth-cone motility.
Schwannoma in Dogs Schwannomas are tumors that originate in the myelin sheath. The myelin sheath is produced by the Schwann cell, a specialized cell which surrounds the peripheral nerves, providing mechanical and physical support for the nerves as well as insulating the nerves that transmit the nervous systemâs electrical signals.