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Lactoferrin is related to another stool test, calprotectin. Both are substances that are released by WBCs in the stool and are associated with intestinal inflammation. The clinical use of these tests is still relatively new.n endoscopy (colonoscopy or sigmoidoscopy) may be indicated as a follow-up test. Increases in lactoferrin are seen with IBD but also with other inflammatory conditions, with intestinal bacterial infections, some parasitic infections, and with colon cancer.
A lactoferrin test may be ordered when a person has symptoms that suggest that intestinal inflammation may be present and when a doctor wants to distinguish between IBD and a non-inflammatory bowel condition.n endoscopy (colonoscopy or sigmoidoscopy) may be indicated as a follow-up test. Increases in lactoferrin are seen with IBD but also with other inflammatory conditions, with intestinal bacterial infections, some parasitic infections, and with colon cancer.