1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
1 Biomechanical problems that increase pressures in the heel area. 2  Prolonged standing, especially on hard floors.  Obesity, which increases the pressure on the normal fat pad under the heel, causing it to expand sideways. If your skin is not supple and flexible, the pressure can cause cracking or fissures.