1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Allergists and allergy patients should thus realize that, just as dust mite allergy can cause eyelid eczema (among other symptoms), an inflammatory response to demodex mite infestation can cause eyelid blepharitits and possibly rosacea. Jeffrey Miller MD, FACAAI. Mission: Allergy, Inc. Hawleyville, CT.