1 Coadministration with moderate CYP3A4 and/or PgP inhibitors: Reduce dose by 50%; administer every other day if dose reduction is required for patients receiving the lowest available strength and maintain trough concentrations of 5 to 15 ng/mL.
A pregnant mouse can give birth to six to 12 babies in one litter. A female mouse can become pregnant several times a year. One mouse couple can produce 40 or more babies in one year.
1 A litter of six to ten young are born after a gestation period of about three weeks. 2  Young rats are weaned at around 20 days of age and can breed at three to four months of age.  Younger rats will mate in the same location in which they were born or will migrate to a new, unoccupied territory.