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A: The PCORI fee is an annual fee paid by the issuers and sponsors of certain types of health plans. It is intended to help fund the Patient-Centered Outcomes Research Institute, which compiles and distributes findings of comparative clinical effectiveness. The fee was established as a part of the Affordable Care Act.
The PCT international patent application filing fee is around $4000. The nationalization fees can range from $2000-$7000 per country to file. After that there are prosecution costs in each country until the application hopefully issues within a few years as a patent.