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Skin lesions have a wide variety of causes. The most common causes of skin lesions are injury, aging, infectious diseases, allergies, and small infections of the skin or hair follicles.Chronic diseases such as diabetes or autoimmune disorders can cause skin lesions.Skin cancer or precancerous changes also appear as skin lesions.ommon causes of skin lesions. Changes in the appearance of the skin can result from common conditions such as: 1  Acne. 2  Boils and carbuncles. 3  Folliculitis. 4  Freckles. 5  Nevi (moles) and other benign skin growths.
Another type of skin bump to be concerned about is that caused by skin cancer. There are several types of skin cancer, all requiring treatment: 1  Basal cell carcinoma appears on sun-exposed skin and produces pain and bleeding in the early stages. 2  The associated bumps may be discolored, shiny, or scar-like. Psoriasis is a skin disease that produces scaly, red, inflamed patches on your skin that may be itchy. 2  Keloids are smooth, raised growths that form around wounds. 3  Keratosis pilaris is a skin condition characterized by overgrowth of a protein called keratin. 4  It causes small bumps around hair follicles on the body.