1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
This information shows the various causes of Simian crease, and how common these diseases or conditions are in the general population. This is not a direct indication as to how commonly these diseases are the actual cause of Simian crease, but gives a relative idea as to how frequent these diseases are seen overall. 2 diseases that are rare.