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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
In those with healthy immune and endocrine systems, cortisol works to moderate the inflammation caused by an immune system response, but it does not completely eliminate it. Cortisol levels can become imbalanced during the different stages of Adrenal Fatigue.levated cortisol. During the early stages of Adrenal Fatigue, your HPA axis is firing on all cylinders and producing lots of stress hormones. This means that your cortisol level is high, which suppresses the immune system and reduces inflammation.