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They also carry out important functions in both the CNS and PNS. Schwann cells express the ERM proteins and merlin, but the absence of merlin alone results in NF2-related schwannomas, indicating that merlin has a distinct function in these cells. In neurons, the ERM proteins regulate key aspects of actin-dependent growth-cone motility.
In your nervous system, cells called Schwann cells grow exceedingly large cell membranes, which wrap tightly around the long processes of nerves. Cell membranes of Schwann cells are unique in that they contain as much as 50 percent more cholesterol and up to 75 percent less protein than other types of cell membranes.This wrapping forms a thick insulating layer of cholesterol-based cell membrane known as myelin.yelin may also contain a small percentage of saturated fatty acids, which decrease the fluidity of the myelin membrane compared to cholesterol, which provides considerable membrane fluidity, according to Patricia Armati, PhD., editor of the book The Biology of Oligodendrocytes..