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It may be time to talk to your doctor. PREMARIN is a prescription medicine used to treat moderate to severe hot flashes due to menopause. Learn about PREMARINÂ® (conjugated estrogens tablets, USP) for the treatment of moderate to severe hot flashes due to menopause. You, your menopause, and your hot flashes. Keeping track of your hot flashes may be helpful.
Alternative Progestin / Estrogen Combinations. As Prempro is a combination progestin/estrogen product approved for the treatment of symptoms of menopause and osteoporosis in women who have not had a hysterectomy (still have a uterus), hormone replacement therapy (HRT) with a similar product might be advisable.ll progestin/estrogen combination products, including Prempro, carry similar risks and warnings, such as potential breast tenderness, weight gain, mental changes and a slight increase for the risk of blood clots and several types of cancer. You Might Also Like.