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They also carry out important functions in both the CNS and PNS. Schwann cells express the ERM proteins and merlin, but the absence of merlin alone results in NF2-related schwannomas, indicating that merlin has a distinct function in these cells. In neurons, the ERM proteins regulate key aspects of actin-dependent growth-cone motility.
Confidence votes 48. Special glia called Schwann cells form the myelin sheath which cover axons in the peripheral nervous system. The myelin sheath is actually two layers. The first layer surrounding the axon is called the myelin sheath and it is made up of the plasma membrane of the Schwann cells. The Schwann cells cytoplasm creates the second layer and is called the neurolemma. A neuron in the peripheral nervous system with a myelin sheath is called a myelinated neuron.