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Depression and anxiety may also cause you to eat more and exercise less than normal. Metabolic or hormonal disruptions, such as hypothyroidism or polycystic ovary syndrome, can cause sudden weight gain and bloating. Cushing's disease can also cause rapid weight gain, especially in the upper body.
Hormone therapy does not cause weight gain, according to the Cleveland Clinic's website. You may feel bloated while taking hormones -- water retention is a side effect of estrogen therapy that usually dissipates with extended use. An adjustment to your estrogen dosage might eliminate water weight build-up.