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A Sharecare Ad Target User , Administration, answered. An outbreak of oral herpes, or cold sores, should go away on its own in about one or two weeks. Antiviral medications can help them heal faster if taken early. Talk to your doctor if your cold sores do not go away after two weeks. Helpful? 1 person found this helpful.
Vitamin B6. Vitamin B6 is also very useful in the treatment of cold sores. It helps to strengthen your immune system by producing antibodies which can fight infections like cold sores and provide quicker healing if you are suffering from cold sores.