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Schwann cells are the supporting cells of the PNS. Like oligodendrocytes schwann cells wrap themselves around nerve axons, but the difference is that a single schwann cell makes up a single segment of an axon's myelin sheath.
Schwann cells make myelin in the peripheral nervous system (PNS: nerves) and oligodendrocytes in the central nervous system (CNS: brain and spinal cord). In the PNS, one Schwann cell forms a single myelin sheath (Figure 1A).ntriguingly, in normally unmyelinated fibers, forced expression of neuregulin 1 type III in the postganglionic fibers of sympathetic neurons grown in culture can be forced to myelinate. Thus, the level of neuregulin 1 type III on the PNS axons is a key instructive signal for myelination.