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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Low Cortisol Symptoms. When the adrenal glands become inactive or fail to produce sufficient amounts of cortisol, the condition is called primary hypoadrenalism. Another name for this condition is Addisonâs disease, an autoimmune disease where antibodies are sent to attack the adrenal cortex.