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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Fatigue caused by overworked adrenal glands may be difficult to treat, especially since adrenal fatigue is not an official diagnosis. However, patients experiencing symptoms of cortisol imbalance due to stress can certainly find ways to eliminate stress from their lives or deal with it in healthy ways.