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Denis transfused the blood from a sheep to a 15-year old boy and later to a labourer, both of whom survived the transfusions. In 1818, British obstetrician James Blundell successfully transfused human blood to a patient who had hemorrhaged during childbirth. In 1901, Karl Landsteiner, an Austrian physician discovered the first human blood groups, which helped transfusion to become a safer practice.
The first blood transfusion in recorded history took place in 1665. Before the discovery of blood typing, doctors did not perform any screening tests before a transfusion. Some early blood transfusion devices were nothing more than a tube system to transport blood from the donor directly into the veins of the recipient.