1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
WHAT CAUSES SCHMORL'S NODULES? Schmorl's nodules tend to occur after trauma to the spine that causes wear and tear to it over time. Usually, if repeated trauma caused the formation of Schmorl's nodule, the patient does not remember a specific motion that caused the pain to begin.