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Pathophysiology of NSTEMI vs STEMI: Pathophysiologically, NSTEMI is somewhat different from STEMI. NSTEMI occurs by developing a complete occlusion of a minor coronary artery or a partial occlusion of a major coronary artery previously affected by atherosclerosis. This causes a partial thickness damage of heart muscle.
Between July 2008 and September 2009, data for 41 683 patients with NSTEMI and 27 860 patients with STEMI were captured at 309 US hospitals participating in the AR-G, a quality improvement registry of patients in the US with MI.