Gastrointestinal: Adjective referring collectively to the stomach and small and large intestines. The commonly used abbreviation for gastrointestinal is GI. (Outside of medicine, GI can also stand for galvanized iron, general issue or government issue-as in GI Joe).
Before the extracellular matrix is calcified, the tissue is called osteoid (bone-like) tissue. When the concentrations of calcium and phosphate ions rise high enough, they are deposited into the extracellular matrix, and the bone calcifies.
Osteoblasts are bone-forming cells that descend from osteoprogenitor cells. They form a protein mixture known as osteoid, which mineralizes to become bone. Osteoid is primarily composed of Type I collagen. Osteoblasts also manufacture hormones, such as prostaglandins, to act on the bone itself.