1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Causes : Blisters are caused due to skin injury or due to torn skin. When skin is exposed with harsh chemicals like detergent it can lead to formation of blisters. Blood blisters can be caused due to excess of heat like that of sunburn. Sometimes, underlying diseases like impetigo and chickenpox can also cause blisters. Blood blisters can be caused due to constant rubbing of the skin which is often caused for baseball pitchers. It can occur when sharp tool tears the skin. Frostbite can also cause blisters on the skin.