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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
If the adrenal glands are functioning normally, then cortisol levels will rise with the ACTH stimulation. If they are damaged or not functioning properly, then the cortisol level will be low. A longer version of this test (1-3 days) may be performed to help distinguish between adrenal and pituitary insufficiency. cortisol test may be ordered when a person has symptoms that suggest a high level of cortisol and Cushing syndrome, such as. 1  High blood pressure (hypertension). 2  High blood sugar (glucose). 3  Obesity, especially in the trunk. 4  Fragile skin. 5  Purple streaks on the abdomen. 6  Muscle wasting and weakness.