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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Cortisol also helps normalize blood sugar levels. When the pressure is on, your cortisol levels can run high. Over time, continuously high cortisol levels lead to high blood pressure, weight gain, insomnia, irritable bowel syndrome (IBS), low sex drive and anxiety; it is also a contributing factor to heart disease.