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Skin lesions have a wide variety of causes. The most common causes of skin lesions are injury, aging, infectious diseases, allergies, and small infections of the skin or hair follicles.Chronic diseases such as diabetes or autoimmune disorders can cause skin lesions.Skin cancer or precancerous changes also appear as skin lesions.ommon causes of skin lesions. Changes in the appearance of the skin can result from common conditions such as: 1  Acne. 2  Boils and carbuncles. 3  Folliculitis. 4  Freckles. 5  Nevi (moles) and other benign skin growths.
The major types of secondary skin lesions are: 1  Ulcer. Lesion that involves loss of the upper portion of the skin (epidermis) and part of the lower portion (dermis). 2  Scale. A dry, horny build-up of dead skin cells that often flakes off the surface of the skin. 3  Crust. A dried collection of blood, serum, or pus.  Erosion.