1 Management of chronic, intractable, non-terminal pain that are not responsive to other modalities; 2  Treatment of cancer pain in those patients who have short life expectancy (less than a year); and.  Alternative management to treat spasticity in order to improve balance, gait, self-care, and global rehabilitation.
Diagnosing modic changes. 1  In Modic type 1 there is vascular development in the vertebral body, with findings of inflammation and edema, but no trabecular damage or marrow changes. 2  In Modic type 2 there are changes in bone marrow, with fatty replacement of formerly red, cellular marrow normally seen there.
Changes in a cell's membrane potential are classified as either graded or action potentials. In graded potentials, the amplitude of the change is proportional to the magnitude of the input. In action potentials, the amplitude of the change is independent of input (all-or-none). V m changes can be due to either the opening or the closing of ion channels.