1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
In about one out of five people previously infected with chickenpox, the virus wakes up, or reactivates, often many years or decades after a childhood chickenpox infection. When the virus is reactivated and causes shingles, the resulting virus is usually referred to as herpes zoster virus. Researchers do not know what causes this reactivation. What is known is that after reactivation, the virus travels along a sensory nerve into the skin and causes shingles.