Let's further define mutation as a heritable change in the genetic material. This point becomes important in multicellular organisms where we must distinguish between changes in gametes (germline mutations) and changes in body cells (somatic mutations).
Statistical significance relates to the question of whether or not the results of a statistical test meets an accepted criterion level. In psychology this level is typically the value of p < .05. The criteria of p < .05 was chosen to minimize the possibility of a Type I error, finding a significant difference when one does not exist. It does not protect us from Type II error, failure to find a difference when the difference does exist.
Significant figures are important because they indicate the degree of accuracy - the minimum amount by which a quantity is distinguished to be different from a similar amount.The more significant figures the more accurate the data will be.