1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
A study of 340 patients published in 1982 found an earlobe crease to be a sign associated with aging and CAD. The crease suggested the presence of a more severe form of heart disease in people who were showing symptoms. The earlobe crease, the researchers wrote, âmay identify a subset of patients prone to early aging and to the early development of coronary artery disease, whose prognosis might be improved by early preventative measures.â