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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Addison's Disease Addison's disease is basically the opposite of Cushing's disease: underproduction of cortisol in the body. Common symptoms are lethargy, weakness, depression, weight loss, lack of appetite, vomiting and diarrhea, drinking more, urinating more, shaking and dehydration.