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The organ system in which the blood is pumped through the heart and circulates throughout the body through the blood vessels. Supplement. The cardiovascular system is a closed circulatory system seen in humans and other vertebrates. Its components include the heart, blood vessels, and blood.
Cardiovascular disease (CVD) is a broad term for a range of diseases affecting the heart and blood vessels. A heart attack or stroke may be the first warning of an underlying disease.