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Denis transfused the blood from a sheep to a 15-year old boy and later to a labourer, both of whom survived the transfusions. In 1818, British obstetrician James Blundell successfully transfused human blood to a patient who had hemorrhaged during childbirth. In 1901, Karl Landsteiner, an Austrian physician discovered the first human blood groups, which helped transfusion to become a safer practice.
Dr. Vasilii Kolessov, a Russian cardiac surgeon, performed the first internal mammary to coronary artery anastomosis in 1964. Dr Rene Favaloro, a physician at the Cleveland Clinic, performed the first saphenous vein operation by harvesting a vein from a patients leg and bypassing the right coronary artery in 1967. Soon after Dr. Dudley Johnson in Milwaukee used the vein grafts to bypass the left coronary arteries.