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Pulmonary edema facts. 1  Pulmonary edema is typically caused by filling of alveoli in the lungs by fluid leaking out of the blood. 2  Pulmonary edema may be caused by a number of cardiac or non-cardiac conditions.  Breathing difficulty is the main manifestation of pulmonary edema.
When excess fluid enters this space, it compresses the lungs so that they cannot fully expand and results in impaired breathing. It must be emphasized that a pleural effusion involves fluid on the outside or surrounding the lungs, not within the lung tissues. Fluid accumulation within the lungs is generally called pulmonary edema.