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A Sharecare Ad Target User , Administration, answered. An outbreak of oral herpes, or cold sores, should go away on its own in about one or two weeks. Antiviral medications can help them heal faster if taken early. Talk to your doctor if your cold sores do not go away after two weeks. Helpful? 1 person found this helpful.
Natural cold sore remedies include: eat immune-boosting foods, supplement with vitamin E and C, boost your zinc intake, take L-lysine, use sunscreen, apply aloe vera gel, use peppermint essential oil, apply vanilla oil or extract, drink echinacea tea, get a new toothbrush, avoid touching the outbreak, and ice it.