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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Often many of these symptoms can also be caused by neurotransmitter imbalances. Itâs helpful to take a urine test to evaluate your levels of common neurotransmitters along with the set of four cortisol tests and a DHEA test to evaluate adrenal gland function.ortisol imbalances often come along with other symptoms of stress and fatigue and energy problems. Depressive symptoms and anxiety are common, no wonder because it is depressing and anxiety-inducing when you feel you canât function normally.