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Low or normal TSH, low free T3 or T4 Low or normal TSHand low free T3 or T4 test resultsrepresent a typical pattern in unwell patients with non-thyroidal illness, the most common combination of resultsbeing a low free T3 with a TSH in the normal range(panel 4).ge of onset varies from the neonatalperiod to adulthood, and a smooth or multinodular goitrecan develop. 20,21 Closely similar somatic mutations areresponsible for 80% of toxic nodules. Low TSH, normal free T3 or T4 Low TSH and normal free T3 and T4 test results areusually seen with thyroxine ingestion (panel 3).
When thyroid function is not sufficient to meet the bodyâs needs it is called hypothyroidism, and may stem from various sourcesâ¦. â For one, the thyroid may not make enough of the T4 form of thyroid hormone due to a problem with the thyroid itself. In this case, T4 levels would be low and TSH would be high because there wouldnât be enough T4 to inhibit the pituitaryâs production of TSH in the negative feedback loop.