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Definition. Arthrokinematics refers to the movement of joint surfaces. The angular movement of bones in the human body occurs as a result of a combination of rolls, spins, and slides. 1  A roll is a rotary movement, one bone rolling on another. 2  A spin is a rotary movement, one body spinning on another. 3  A slide is a translatory movement, sliding of one joint surface over another.
meaning and application of toxicokinetics and to provide guidance on developing test strategies in toxicokinetics. The guidance highlights the need to integrate pharmacokinetics into toxicity testing, which should aid in the interpretation of the toxicology findings and promote rational study design development. Toxicokinetic measurements are normally integrated within the toxicity studies and as such are described in this document as 'concomitant toxicokinetics' (Note 1). Alternatively, data may be generated in other supportive studies conducted by mimicking the conditions of the toxicity studies.