1 Coadministration with moderate CYP3A4 and/or PgP inhibitors: Reduce dose by 50%; administer every other day if dose reduction is required for patients receiving the lowest available strength and maintain trough concentrations of 5 to 15 ng/mL.
A pregnant mouse can give birth to six to 12 babies in one litter. A female mouse can become pregnant several times a year. One mouse couple can produce 40 or more babies in one year.
Mice should be weaned at 3 to 4 weeks after birth. Pups must be weaned if the same mom gives birth to a second litter. The pups should be robust, active, have open eyes, teeth and adult fur rather than the sparser fur of babies. They need to be able to jump up to the top of the cage to feed and drink.