Antibiotic resistance. Bacteria are termed drug-resistant when they are no longer inhibited by an antibiotic to which they were previously sensitive. The emergence and spread of antibacterial-resistant bacteria has continued to grow due to both the over-use and misuse of antibiotics.
As a principal organization of the Civil Rights Movement, the Southern Christian Leadership Conference (SCLC) championed the use of nonviolent direct action to end legal and social discrimination against African Americans.
The amino and carboxy terminus of Scc1 bind Smc1 and Smc3. Once Scc1 binds the SMC proteins, Scc3 can also associate by binding with the C-terminal region of Scc1. When Scc1 binds on both Smc1 and Smc3, the cohesin complex forms a closed ring structure. When it binds to only one of the SMC proteins, the complex forms an open ring. Early studies suggested various ways in which cohesin may entrap DNA, including as a monomer that holds both homologues together, and a hand-cuff model where two intertwining cohesin complexes each hold one sister chromatid.