1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
A falciform retinal fold can be caused by: 1  Retinopathy of prematurity. 2  Familial exudative vitreoretinopathy (FEVR) 3  Norrie's disease. 4  All of the above.