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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Cortisol. Cortisol depletion is a hallmark of Adrenal Exhaustion. In the early stages of Adrenal Fatigue, cortisol output will rise at first and this will be the body's first line of defense. Cortisol demand is met with a higher cortisol output.