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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
In addition to persistent fatigue, these include subclinical depression, low sex drive, hypoglycemia (low blood sugar) and weakened immune response to infections. âThe symptoms of adrenal fatigue are many and varied,â Wilson explains, âbecause cortisol goes to virtually every part of the body. So when cortisol levels drop, lots of different systems are likely to be affected.