1 Coadministration with moderate CYP3A4 and/or PgP inhibitors: Reduce dose by 50%; administer every other day if dose reduction is required for patients receiving the lowest available strength and maintain trough concentrations of 5 to 15 ng/mL.
A pregnant mouse can give birth to six to 12 babies in one litter. A female mouse can become pregnant several times a year. One mouse couple can produce 40 or more babies in one year.
When Atwood was writing The Handmaid's Tale in the early 1980s, about 3.6 million babies were born in the U.S. per year. Thirty years later, birth rates are again hovering in that range, after a boom in the early 2000s, with birth rates for women under 30 steadily declining.