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Some medications may cause bloating and weight gain because they encourage your body to retain fluid. The extra weight is often due to swelling, or edema, from this excess fluid. Some medications known to cause weight gain include steroids, tranquilizers, some antidepressants and lithium.
Hormone Therapy and Weight Gain. Hormone therapy does not cause weight gain, according to the Cleveland Clinic's website. You may feel bloated while taking hormones -- water retention is a side effect of estrogen therapy that usually dissipates with extended use.