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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
The list of signs and symptoms mentioned in various sources for Adrenal gland hyperfunction includes the 64 symptoms listed below: 1  Excessive fat on top of back-excess corticosteroids. 2  Increased libido-excess androgenic steroids. 3  Loss of scalp hair-excess corticosteroids.eview the available symptom checkers for these symptoms of Adrenal gland hyperfunction: 1  Excessive fat on top of back -- Symptom Checker. 2  Increased libido -- Symptom Checker. 3  Increased facial hair -- Symptom Checker.