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Pulmonary edema facts. 1  Pulmonary edema is typically caused by filling of alveoli in the lungs by fluid leaking out of the blood. 2  Pulmonary edema may be caused by a number of cardiac or non-cardiac conditions.  Breathing difficulty is the main manifestation of pulmonary edema.
1 Lung cancer can also cause fluid to accumulate around the lungs, making it harder for the affected lung to expand fully when you inhale. 2  Coughing up blood. 3  Lung cancer can cause bleeding in the airway, which can cause you to cough up blood (hemoptysis). 4  Sometimes bleeding can become severe.