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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
In addition to fatigue, women with adrenal imbalance may experience weakness, moodiness or depression, hair loss, weight gain and dozens of other symptoms â some very serious.Women with these symptoms can undergo a series of tests that evaluate markers of stress, including cortisol and DHEA levels.n addition to fatigue, women with adrenal imbalance may experience weakness, moodiness or depression, hair loss, weight gain and dozens of other symptoms â some very serious.