Anti-HMGCR antibody titers ranged from 2,800 to 80,000 (mean 12,606) and were similar in patients with and without statin exposure (table). Serum CK was high in 83% of our patients (mean 4,232 IU/L; range 26 to 27,000). Fifty percent of patients with normal strength had high serum CK (mean 447 IU/L; range 48â1,846).atients with HMGCR antibodyâassociated myopathies present with weakness and muscle discomfort and often have damage to both perimysial connective tissue and muscle fibers, with necrosis and myonuclear pathology.
Density dependence occurs when the population growth rate, or constituent gain rates (e.g. birth and immigration) or loss rates (death and emigration), vary causally with population size or density (N). When these parameters do not vary with N, they are densityâindependent.
Density Independent Factors. These factors occur regardless of a population size in a species. Usually these are environmental disasters, such as a forest fire, tidal wave etc that destroy the natural ecosystem that a species survives in.he result is that ecosystem can no longer sustain the species' population size and they begin to die out until the population size is at a more sustainable level. Human intervention also has increasingly played a part in determining the population of species, either via domestication or consequence from our actions.