Anti-HMGCR antibody titers ranged from 2,800 to 80,000 (mean 12,606) and were similar in patients with and without statin exposure (table). Serum CK was high in 83% of our patients (mean 4,232 IU/L; range 26 to 27,000). Fifty percent of patients with normal strength had high serum CK (mean 447 IU/L; range 48â1,846).atients with HMGCR antibodyâassociated myopathies present with weakness and muscle discomfort and often have damage to both perimysial connective tissue and muscle fibers, with necrosis and myonuclear pathology.
Density dependence occurs when the population growth rate, or constituent gain rates (e.g. birth and immigration) or loss rates (death and emigration), vary causally with population size or density (N). When these parameters do not vary with N, they are densityâindependent.
In the context of populations, a limiting factor is a factor that causes population growth to decrease. Density-Dependent Factors Density-Dependent Factors A limiting factor that depends on population size is called a density-dependent limiting factor. Density-Dependent Factors Density-dependent limiting factors include: â¢ competition â¢ predation â¢ parasitism â¢ disease Density-Dependent Factors Density-dependent factors operate only when the population density reaches a certain level. These factors operate most strongly when a population is large and dense. They do not affect small, scattered populations as greatly. Density-Dependent Factors Competition When populations become crowded, organisms compete for food, water space, sunlight and other essentials. Competition among members of the same species is a density-dependent limiting factor. Density ...