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Pulmonary edema facts. 1  Pulmonary edema is typically caused by filling of alveoli in the lungs by fluid leaking out of the blood. 2  Pulmonary edema may be caused by a number of cardiac or non-cardiac conditions.  Breathing difficulty is the main manifestation of pulmonary edema.
The lungs may swell because the disease can fill up the air spaces inside the lungs, making breathing difficult. The infection that causes the pneumonia can spread into the bloodstream and then to other organs. Fluid can collect between the lining (pleurae) of the lungs and the lining of the inside of the chest. When fluid collects inside it is called pleural effusion.