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They also carry out important functions in both the CNS and PNS. Schwann cells express the ERM proteins and merlin, but the absence of merlin alone results in NF2-related schwannomas, indicating that merlin has a distinct function in these cells. In neurons, the ERM proteins regulate key aspects of actin-dependent growth-cone motility.
Myelinating Schwann cells begin to form the myelin sheath in mammals during fetal development and work by spiraling around the axon, sometimes with as many as 100 revolutions. A well-developed Schwann cell is shaped like a rolled-up sheet of paper, with layers of myelin in between each coil.The inner layers of the wrapping, which are predominantly membrane material, form the myelin sheath while the outermost layer of nucleated cytoplasm forms the neurolemma.n myelinated axons, Schwann cells form the myelin sheath (see above). The sheath is not continuous. Individual myelinating Schwann cells cover about 100 micrometres of an axonâequating to approximately 10,000 Schwann cells along a 1 metre length of the axon.