1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Some of the most common causes include: 1  bacteria. 2  yeast/fungus (aspergillosis) 3  moisture (which can create a prime growing environment for bacteria and yeast) 4  viruses. 5  mites (more common in puppies than in adults) 6  drug reactions.