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Denis transfused the blood from a sheep to a 15-year old boy and later to a labourer, both of whom survived the transfusions. In 1818, British obstetrician James Blundell successfully transfused human blood to a patient who had hemorrhaged during childbirth. In 1901, Karl Landsteiner, an Austrian physician discovered the first human blood groups, which helped transfusion to become a safer practice.
A wide variety of patients receive blood transfusions. The various components of donated blood are used to treat different conditions. For example, red blood cells are transfused to patients who have lost blood due to trauma or surgery, and to treat anemia (including sickle cell anemia). Cancer patients need platelet transfusions to replace the healthy cells that are destroyed during chemotherapy and radiation.