1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Shingles is caused by the herpes zoster virus, the same virus that causes chicken pox. Aging, compromised immunity or other illness can cause the virus to awaken from dormancy. Shingles usually affects the torso, causing a painful rash with blisters. When shingles affects the eye, it is known as herpes zoster opthalmicus. Treatment includes oral antiviral medications and oral corticosteroids. It's important to seek treatment right away to prevent complications, including severe, recurring pain or relapses of the disease.