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They also carry out important functions in both the CNS and PNS. Schwann cells express the ERM proteins and merlin, but the absence of merlin alone results in NF2-related schwannomas, indicating that merlin has a distinct function in these cells. In neurons, the ERM proteins regulate key aspects of actin-dependent growth-cone motility.
A nerve fiber may be myelinated and/or unmyelinated. In the central nervous system (CNS), myelin is produced by oligodendroglia cells. Schwann cells form myelin in the peripheral nervous system (PNS). Schwann cells can also make a thin covering for an axon which does not consist of myelin (in the PNS). A peripheral nerve fiber consists of an axon, myelin sheath, Schwann cells and its endoneurium. There are no endoneurium and Schwann cells in the central nervous system.