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Skin lesions have a wide variety of causes. The most common causes of skin lesions are injury, aging, infectious diseases, allergies, and small infections of the skin or hair follicles.Chronic diseases such as diabetes or autoimmune disorders can cause skin lesions.Skin cancer or precancerous changes also appear as skin lesions.ommon causes of skin lesions. Changes in the appearance of the skin can result from common conditions such as: 1  Acne. 2  Boils and carbuncles. 3  Folliculitis. 4  Freckles. 5  Nevi (moles) and other benign skin growths.
Acne affects the areas of the skin where sebaceous follicles are in abundance. Therefore, acne lesions are mostly found on the face, neck, upper chest and the back. In severe acne cases, nodules can extend all the way to the upper arms, thighs and buttocks.Different factors can cause acne. However, the most important causes of acne are hormones and infections.apules: Papules are one of the first groups of inflammatory acne lesions to appear on the skin. In a way, they are the precursors of nodules. Papules are red, tender, inflamed bumps with no heads that appear on the skin. When squeezed, they may traumatize the skin enough to give rise to nodules and cause scarring.