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The hypothalamus is a brain structure made up of distinct nuclei as well as less anatomically distinct areas. It is found in all vertebrate nervous systems. In mammals, magnocellular neurosecretory cells in the paraventricular nucleus and the supraoptic nucleus of the hypothalamus produce neurohypophysial hormones, oxytocin and vasopressin. These hormones are released into the blood in the posterior pituitary.
Although the hypothalamus does not produce the hormones of the anterior pituitary as in the posterior pituitary, it plays an important role in their production. Releasing hormones synthesized by hypothalamic neurons travel down axons and diffuse into the primary plexus of the hypophyseal portal system.