1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
The first cause could be an infection in your gastrointestinal tract (GIT). This kind of infection is caused by the Helicobacter pylori bacteria, also known as Giardia. This is a parasite and causes people to have sulfur burps. The parasite can lead to the development of ulcers, abdominal cramps, diarrhea and vomiting. The only way that the bacteria are spread is through poor hygiene, oral-fecal transmission, and in untreated water. Another cause is improper eating patterns.