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They also carry out important functions in both the CNS and PNS. Schwann cells express the ERM proteins and merlin, but the absence of merlin alone results in NF2-related schwannomas, indicating that merlin has a distinct function in these cells. In neurons, the ERM proteins regulate key aspects of actin-dependent growth-cone motility.
What are Trigeminal Schwannomas? Trigeminal Schwannomas are a type of peripheral intracranial nerve sheath tumor that develop at the skull base and originate from the Schwann cells. Schwann cells are a type of glial cell that helps protect the transmission of messages and instructions by neurons in the peripheral nervous system.