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Some medications may cause bloating and weight gain because they encourage your body to retain fluid. The extra weight is often due to swelling, or edema, from this excess fluid. Some medications known to cause weight gain include steroids, tranquilizers, some antidepressants and lithium.
Wellbutrin affects different brain chemicals than do SSRIs, and some of those chemicals may play a role in appetite. Researchers donât know all the reasons why some antidepressants appear to cause weight gain and others do not, Perlis said. Some people gain weight and others lose weight as a result of depression. Consequently, researchers have trouble untangling the effects of medication and the effects of depression on weight, Perlis said. The new study also canât prove the antidepressants were responsible for weight gain.