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Skin lesions have a wide variety of causes. The most common causes of skin lesions are injury, aging, infectious diseases, allergies, and small infections of the skin or hair follicles.Chronic diseases such as diabetes or autoimmune disorders can cause skin lesions.Skin cancer or precancerous changes also appear as skin lesions.ommon causes of skin lesions. Changes in the appearance of the skin can result from common conditions such as: 1  Acne. 2  Boils and carbuncles. 3  Folliculitis. 4  Freckles. 5  Nevi (moles) and other benign skin growths.
Conditions that may cause skin peeling include: Allergic reactions; Infections, including some types of staph and fungal infections; Immune system disorders; Cancer and cancer treatment; Genetic disease, including a rare skin disorder called acral peeling skin syndrome that causes painless peeling of the top layer of skin