1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
She states that small pests, including aphids, whiteflies and spider mites, suck the sap from the leaves, which causes curling, yellowing and leaf distortion. Several bacterial and fungal diseases, such as verticillium wilt and symptoms caused by the mosaic virus, may also lead to the yellowing of cucumber plants. Carroll further explains that nitrogen deficiency not only causes the plant to turn yellow, but also leads to stunted growth.