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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
In other words, if someone is having symptoms of low cortisol, perhaps it's not the adrenal glands that need help, but rather something in the body is actually telling the adrenal glands to produce less cortisol. The new model looks at the interconnection of neurotransmitters, hormones, and the immune system. Cortisol levels may be normal or high during this phase, but DHEA levels may be low, which can negatively impact Testosterone levels. 2  Exhaustion â This final stage is typically characterized by low adrenal function, with low cortisol and DHEA levels. 3  This phase is what most people refer to as adrenal fatigue..