Anti-HMGCR antibody titers ranged from 2,800 to 80,000 (mean 12,606) and were similar in patients with and without statin exposure (table). Serum CK was high in 83% of our patients (mean 4,232 IU/L; range 26 to 27,000). Fifty percent of patients with normal strength had high serum CK (mean 447 IU/L; range 48â1,846).atients with HMGCR antibodyâassociated myopathies present with weakness and muscle discomfort and often have damage to both perimysial connective tissue and muscle fibers, with necrosis and myonuclear pathology.
Density dependence occurs when the population growth rate, or constituent gain rates (e.g. birth and immigration) or loss rates (death and emigration), vary causally with population size or density (N). When these parameters do not vary with N, they are densityâindependent.
Working Population: people in employment who have to support the dependent population. Youthful Population: in the population structure of LEDCs, there is often a higher proportion of young people due to high birth rates and a reduction in infant mortality due to better nutrition, education and medical care.This may create problems since the children need feeding, housing, education and eventually a job.atural Increase or Decrease: the difference between the birth rate and the death rate. Additional effects of migration are not included. Natural Population Change: the difference in number between those who are born and those who die in a year. Additional effects of migration are not included.