For example, your standard fixed overhead cost is $3 per unit. If your actual fixed overhead cost is $4 per unit, you have an unfavorable variance of $1. You spent $1 more per unit than you had originally budgeted.
In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. They are the chief protein components of chromatin, acting as spools around which DNA winds, and playing a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long (a length to width ratio of more than 10 million to 1 in human DNA).
Types of histones. Each octamer has two pairs of different histone proteins: H2A, H2B, H3 and H4. They are arranged as a pair of H2A-H2B dimers, and an (H3)2(H4)2 tetramer. There is an additional type of histone, the linker histone H1, which is present in condensed DNA. The C-terminal end is primarily responsible for histone-DNA and histone-histone interactions; 2  The N-terminal consists of a charged, flexible tail which in histones H2B and H3 bury into the minor grooves of DNA, probably to stabilise the interaction.