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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
There may also be additional symptoms due to the underlying cause of the hypopituitarism, such as the effects of pressure from a tumour. Symptoms can include: Low adrenocorticotropic hormone levels can lead to decreased production of cortisol by the adrenal glands.