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Denis transfused the blood from a sheep to a 15-year old boy and later to a labourer, both of whom survived the transfusions. In 1818, British obstetrician James Blundell successfully transfused human blood to a patient who had hemorrhaged during childbirth. In 1901, Karl Landsteiner, an Austrian physician discovered the first human blood groups, which helped transfusion to become a safer practice.
The use of a balloon-tipped catheter for the treatment of atherosclerotic vascular disease was first described in 1964 by two interventional radiologists, Charles Dotter and Melvin Judkins, when they used it to treat a case of atherosclerotic disease in the superficial femoral artery of the left leg.