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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Overview. Cortisol is a naturally occurring hormone that is secreted by the adrenal glands located on your kidneys. The levels of cortisol within your body fluctuate normally throughout the day and night.nfertility. Men with high cortisol levels can experience impotence, a medical condition characterized by the inability to have or maintain an erection. These symptoms of cortisol imbalance may also be accompanied by decreased sexual desire.