Anti-HMGCR antibody titers ranged from 2,800 to 80,000 (mean 12,606) and were similar in patients with and without statin exposure (table). Serum CK was high in 83% of our patients (mean 4,232 IU/L; range 26 to 27,000). Fifty percent of patients with normal strength had high serum CK (mean 447 IU/L; range 48â1,846).atients with HMGCR antibodyâassociated myopathies present with weakness and muscle discomfort and often have damage to both perimysial connective tissue and muscle fibers, with necrosis and myonuclear pathology.
Density dependence occurs when the population growth rate, or constituent gain rates (e.g. birth and immigration) or loss rates (death and emigration), vary causally with population size or density (N). When these parameters do not vary with N, they are densityâindependent.
1 3. Explain the factors that limit the biotic potential and carrying capacity of a population, including density-dependent, and density-independent limiting factors. 2  4. Explain how human population growth went from 1 billion in 1800 to 6 billion in 1999. 3  Have a reasonable estimate of the population of the US and world.