Scleritis (inflammation of sclera) is a strong indication of the underlying medical problem. It can be due to fungal, viral or parasitic infection, trauma, exposure to chemicals, poisonous gases or due to post-surgical complications.
Mast cells are granulated cells typically found in connective tissue. These cells mediate immune responses to foreign particles. In particular, they release large amounts of histamine and enzymes in response to antigen recognition.
Histamine is present abundantly in the granules of tissue mast cells and circulating basophils. One of the stimuli that activate mast cells and basophils to release histamine is the binding of antigens to cell-bound IgE antibodies on the surfaces of mast cells and basophils.nother stimulus that activates mast cells to release histamine is the binding of C3a and C5a fragments of complement to specific receptors on mast cells. Activated mast cells release massive amounts of histamine into the surrounding tissue.