Sekine K, Kawashima T and Hashimoto Y. Comparison of the TNF-a Levels Induced by Human-Derived Bifidobacterium longum and Rat-Derived Bifidobacterium animalis in Mouse Peritoneal Cells. Bifidobacteria Microflora 1994;13(2):79-89.
A Sharecare Ad Target User , Administration, answered. An outbreak of oral herpes, or cold sores, should go away on its own in about one or two weeks. Antiviral medications can help them heal faster if taken early. Talk to your doctor if your cold sores do not go away after two weeks. Helpful? 1 person found this helpful.
Treatment: There is no cure for cold sores. However, some medications may relieve pain and soften HSV crusts on the skin. These remedies include: 1  Denavir (pencyclovir cream), a topical antiviral cream recently cleared for marketing by the FDA that may decrease the duration of lesion pain and accelerate healing.