Top Ten Tips for Graduate Students Who Want to Conduct a Meta-analysis. All you need to conduct a meta-analysis is use of one or more comprehensive literature search engines (e.g., Web of Science, PsycINFO, PubMed), access to a basic statistics program such as SPSS or SAS at your disposal, and a good idea for a meta-analysis topic.
Signs and symptoms vary depending on what parts of your body are affected by Wilson's disease. They may include: 1  Fatigue, lack of appetite or abdominal pain.  Jaundice, a yellowing of the skin and the whites of the eye.
The condition is due to mutations in the Wilson disease protein (ATP7B) gene. A single abnormal copy of the gene is present in 1 in 100 people, who do not develop any symptoms (they are carriers). If a child inherits the gene from both parents, the child may develop Wilson's disease. Symptoms usually appear between the ages of 6 and 20 years, but cases in much older people have been described.