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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Symptoms of a cancerous adrenal tumor that causes too much cortisol include: 1  depression. 2  easy bruising. 3  fat behind the neck and shoulders.  hair growth on the face, chest, and back (in 1  women) irregular periods.  weakness in the 1  legs. weight gain around the chest and stomach.