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Skin lesions have a wide variety of causes. The most common causes of skin lesions are injury, aging, infectious diseases, allergies, and small infections of the skin or hair follicles.Chronic diseases such as diabetes or autoimmune disorders can cause skin lesions.Skin cancer or precancerous changes also appear as skin lesions.ommon causes of skin lesions. Changes in the appearance of the skin can result from common conditions such as: 1  Acne. 2  Boils and carbuncles. 3  Folliculitis. 4  Freckles. 5  Nevi (moles) and other benign skin growths.
Causes of localized swelling include: 1  Injury to a specific body area. Bruising (hematoma) from an injury is caused by tears in the small blood vessels under the skin. 2  Infection, which can occur in a joint or under the skin. An abscess is a pocket of pus that forms at the site of infected tissue. Cellulitis is a skin infection that can cause mild or severe swelling. Burns, which can cause swelling at the site of the burn or in a larger area around the burn.