Anti-HMGCR antibody titers ranged from 2,800 to 80,000 (mean 12,606) and were similar in patients with and without statin exposure (table). Serum CK was high in 83% of our patients (mean 4,232 IU/L; range 26 to 27,000). Fifty percent of patients with normal strength had high serum CK (mean 447 IU/L; range 48â1,846).atients with HMGCR antibodyâassociated myopathies present with weakness and muscle discomfort and often have damage to both perimysial connective tissue and muscle fibers, with necrosis and myonuclear pathology.
Density dependence occurs when the population growth rate, or constituent gain rates (e.g. birth and immigration) or loss rates (death and emigration), vary causally with population size or density (N). When these parameters do not vary with N, they are densityâindependent.
Limiting Factors. Limiting factors are factors present in an environment that control the growth, abundance, or distribution of a population of organisms in an ecosystem. The two types of limiting factors are density independent and density dependent limiting factors.ensity-dependent limiting factors affect the size and growth of a population based on population density. In Yellowstone, the competition for resources is a very important limiting factor. An increase in population size decreases the amount of available resources, which then limits the size and growth of a population.