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Skin lesions have a wide variety of causes. The most common causes of skin lesions are injury, aging, infectious diseases, allergies, and small infections of the skin or hair follicles.Chronic diseases such as diabetes or autoimmune disorders can cause skin lesions.Skin cancer or precancerous changes also appear as skin lesions.ommon causes of skin lesions. Changes in the appearance of the skin can result from common conditions such as: 1  Acne. 2  Boils and carbuncles. 3  Folliculitis. 4  Freckles. 5  Nevi (moles) and other benign skin growths.
Common causes of skin changes include: 1  Skin puckering or dimpling. 2  Skin puckering or dimpling can be caused by scarring from a previous operation or infection, but in the majority of cases, no specific reason can be found. 3  Most often it is not a sign of underlying cancer, but should be evaluated with exam and imaging.