Asker's rating. 1  Shackles are brackets installed on the rear leaf springs it causes the rear of the car to be raised giving the car that classic Muscle look. 2  useing a larger shackle will raise the rear of the car allowing slightly bigger tires in the rear. 3  Shackled Means.
Clinical Significance. A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor.
Both IgM and IgG refer to a class of immunoglobulin. Antibodies are produced by the immune system to fight antigens like bacteria and viruses. IgM refers to those antibodies that are produced immediately after an exposure to the disease, while IgG refers to a later response. IgG generally confers immunity to a patient so far as that particular disease is concerned.