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Low levels of high-density lipoprotein cholesterol (HDL), or hypoalphalipoproteinemia (HA), includes a variety of conditions, ranging from mild to severe, in which concentrations of alpha lipoproteins or high-density lipoprotein (HDL) are reduced.
1 HDL cholesterol level. 2  HDL is short for high-density lipoprotein. 3  HDL cholesterol is known as the good, or highly desirable, cholesterol because this type helps remove excess cholesterol from your blood. 4  A low level of HDL is a major risk factor for heart disease.