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Low levels of high-density lipoprotein cholesterol (HDL), or hypoalphalipoproteinemia (HA), includes a variety of conditions, ranging from mild to severe, in which concentrations of alpha lipoproteins or high-density lipoprotein (HDL) are reduced.
Why HDL Matters. Population studies have shown that low levels of HDL cholesterolâless than 40 mg/dL for men and less than 50 mg/dL for womenâincrease the overall risk of coronary artery disease (CAD) and heart attacks.