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Quinine is only approved for the treatment of malaria. Tonic water contains quinine but it does not have enough quinine to help with leg cramps. Common side effects associated with quinine can include headache, nausea, diarrhea, vomiting, hives, fever, ringing in the ears, vision problems, and bleeding problems.
Clearly, quinine can be dangerous for certain people, but the FDA has not banned quinine from tonic water. Quinine gives this beverage its distinctive flavor. Either the FDA doesnât consider tonic water a danger to public health or the agency worries about arousing the ire of millions of gin and tonic drinkers.inging or hissing in the ears can be a complication of quinine. Tonic water should be discontinued completely. For such people, home remedies may be the best way to get relief from nocturnal leg cramps. Our Guide to Leg Pain has instructions on stretching as well as a range of remedies.