Asker's rating. 1  Shackles are brackets installed on the rear leaf springs it causes the rear of the car to be raised giving the car that classic Muscle look. 2  useing a larger shackle will raise the rear of the car allowing slightly bigger tires in the rear. 3  Shackled Means.
Clinical Significance. A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor.
Classes of antibodies: 1  IgG - provides long-term immunity or protection. 2  IgM - first antibody produced in response to an antigenic stimulus. 3  IgA - found in secretions.  IgE - involved in allergic 1  reactions. IgD - not much known about 2  it. Most important classes of antibodies in blood banking are IgM and IgG, and to a certain extent  IgA.