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The key glucocorticoid in humans is cortisone, which is released by the adrenal glands. Cortisone is a glucocorticoid that stimulates the conversion of proteins to glucose in the liver. A glucocorticoid is any one of a group of steroid hormones, such as cortisone, that are produced by the adrenal glands in the kidney and which control carbohydrate, protein, and fat metabolism, and have anti-inflammatory activity.
Common glucocorticoids include prednisone, dexamethasone, and hydrocortisone. While glucocorticoids are widely used as drugs to treat various inflammatory conditions, prolonged glucocorticoid use may have adverse side effects such as immunosuppression, fluid shifts, brain changes, and psychological changes.