It was once believed that lactic acid build-up was the cause of muscle fatigue. The assumption was lactic acid had a pickling effect on muscles, inhibiting their ability to contract. The impact of lactic acid on performance is now uncertain, it may assist or hinder muscle fatigue.
Pioglitazone is an anti-diabetic drug (thiazolidinedione-type, also called glitazones) used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar.
The U.S. Food and Drug Administration (FDA) approved Actos, which is manufactured by Takeda Chemical Industries, on July 15, 1999. Actos includes the active ingredient pioglitazone hydrochloride and is used for treatment of Type 2 and Type 1 diabetes; Type 1 diabetes mellitus; diabetes mellitus inadequate control; and high blood pressure.