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In many cases the knot in the muscle is caused by an abnormal nerve message being sent to the muscle. The abnormal nerve message is, in turn, caused by a misaligned bone in the spine that irritates the nerve. To keep it simple.
Answers. Best Answer: Hey 'Knots' in muscles are not knots atall. As far as I know, what they are is when one group of muscle fibres breaks and heals short than the others after strain or excersise and is at an angle over the muscle.