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In the cell membrane, hydrophilic heads orient to the inside and outside of the membrane, with the hydrophobic molecules inside. This gives the membrane its semi permeable fluid nature.he hydrophilic region in the cell is water-loving and it  attracts the water molecules. It is basically composed of polar  groups which readily dissolve and absorb water.
The phospholipids of a cell membrane are arranged in a double layer called the lipid bilayer. The hydrophilic phosphate heads are always arranged so that they are near water. Watery fluids are found both inside a cell (intracellular fluid) and outside a cell (extracellular fluid).hospholipids make up the basic structure of a cell membrane. A single phospholipid molecule has two different ends: a head and a tail. The head end contains a phosphate group and is hydrophilic. This means that it likes or is attracted to water molecules.