Although an MSI-H result is the hallmark of Lynch syndrome, it is also found in 10% to 15% of sporadic CRC cases. Since MSI results do not rule out Lynch syndrome, MMR gene mutation testing should be considered regardless of MSI status in families with a strong suspicion of Lynch syndrome.
Many of the symptoms of prolactinoma are caused by an excessive amount of prolactin in the blood (hyperprolactinemia) which decreases the ovarian and testicular function. In women, prolactinoma is characterized by irregular menstrual periods, infertility and production of breast milk in women who are not pregnant (galactorrhea).
The symptoms of prolactinomas fall into two categories: those that result from elevated blood prolactin levels, and those that result from compression of the normal pituitary and surrounding tissues. 1  Symptoms caused by elevated blood prolactin â Elevated blood prolactin interferes with the function of the ovaries in women and the testicles in men.