Introduction Elbow joint replacement (also called elbow arthroplasty) can effectively treat the problems caused by arthritis of the elbow. The procedure is also becoming more widely used in aging adults to replace joints damaged by fractures.lbow joint replacement (also called elbow arthroplasty) can effectively treat the problems caused by arthritis of the elbow. The procedure is also becoming more widely used in aging adults to replace joints damaged by fractures.
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Last reviewed on RxList 2/19/2016. Xiaflex (collagenase Clostridium histolyticum) is a nonsurgical enzyme treatment derived from Clostridium histolyticum bacteria for adults with Dupuytren's contracture when a cord can be felt. Xiaflex is available in a generic form as collagenase Clostridium histolyticum. Side effects of Xiaflex include mild pain or tenderness in the treated hand, cracked skin, underarm pain, tendon or ligament damage, nerve injury, and allergic reactions. Xiaflex is available in single-use, glass vials containing 0.9 mg of collagenase derived from Clostridium histolyticum.