Although an MSI-H result is the hallmark of Lynch syndrome, it is also found in 10% to 15% of sporadic CRC cases. Since MSI results do not rule out Lynch syndrome, MMR gene mutation testing should be considered regardless of MSI status in families with a strong suspicion of Lynch syndrome.
Many of the symptoms of prolactinoma are caused by an excessive amount of prolactin in the blood (hyperprolactinemia) which decreases the ovarian and testicular function. In women, prolactinoma is characterized by irregular menstrual periods, infertility and production of breast milk in women who are not pregnant (galactorrhea).
A very high level indicates a prolactinoma, whereas a mildly elevated level may indicate: A small prolactinoma; Certain medical conditions that impair the removal of prolactin from the body Kidney failure; Liver failure; Polycystic ovarian syndrome ; Certain medications and conditions may mildly elevate prolactin levels, and therefore must be considered before making the diagnosis of prolactinoma: 1  Certain antipsychotic and antidepressant medications. 2  Estrogens. 3  Morphine and related narcotics. 4  Severe hypothyroidism. 5  Pregnancy. 6  Stress. 7  Breast stimulation.