Pain in the ankle can result from inflammation or injury to any of the structures in this region, including the bones, joint space, cartilage, ligaments, tendons, or muscles. Ankle pain can be associated with other symptoms including.
People with Down syndrome may have some or all of these physical characteristics: a small chin, slanted eyes, poor muscle tone, a flat nasal bridge, a single crease of the palm, and a protruding tongue due to a small mouth and relatively large tongue.
Physical Symptoms. Common physical signs of Down syndrome include 1  : Decreased or poor muscle tone. 2  Short neck, with excess skin at the back of the neck. 3  Flattened facial profile and nose. 4  Small head, ears, and mouth. 5  Upward slanting eyes, often with a skin fold that comes out from the upper eyelid and covers the inner corner of the eye.