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In the cell membrane, hydrophilic heads orient to the inside and outside of the membrane, with the hydrophobic molecules inside. This gives the membrane its semi permeable fluid nature.he hydrophilic region in the cell is water-loving and it  attracts the water molecules. It is basically composed of polar  groups which readily dissolve and absorb water.
Hydrophobic means water fearing tails and hydrophilic means water loving heads First of all, these terms are involved when you are looking at the cell membrane. The structur â¦ e of the cell membrane is called a phospholipid bilayer.Which means that the cell membrane is actually made to two layers and not one.n the cell membrane, hydrophilic heads orient to the inside and outside of the membrane, with the hydrophobic molecules inside. This gives the membrane its semi permeable fluid nature.