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In the cell membrane, hydrophilic heads orient to the inside and outside of the membrane, with the hydrophobic molecules inside. This gives the membrane its semi permeable fluid nature.he hydrophilic region in the cell is water-loving and it  attracts the water molecules. It is basically composed of polar  groups which readily dissolve and absorb water.
What is the mechanism of action of HCTZ? How does HCTZ work in the body? Hydrochlorothiazide (HCTZ) is a thiazide diuretic. Diuretics work by increasing the amount of fluid excreted by the kidneys. HCTZ reduces the amount of salt (sodium chloride) reabsorbed from the urine by the body in the kidneys at place call the distal convoluted tubule.