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Early signs and symptoms of ALS include: 1  Difficulty walking or doing your normal daily activities. 2  Tripping and falling. 3  Weakness in your leg, feet or ankles.  Hand weakness or 1  clumsiness. Slurred speech or trouble swallowing.  Muscle cramps and twitching in your arms, shoulders and 1  tongue. Difficulty holding your head up or keeping good posture.
In the early stages, the symptoms of ALS -- also called Lou Gehrig's disease -- include:1  Increasing weakness in one limb, especially in a hand. 2  Difficulty walking. 3  Clumsiness of the hands. 4  Fasciculations, which are subtle, light twitches under the skin.5  Impaired speech. 6  Difficulty swallowing.n the early stages, the symptoms of ALS -- also called Lou Gehrig's disease -- include: