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Low levels of high-density lipoprotein cholesterol (HDL), or hypoalphalipoproteinemia (HA), includes a variety of conditions, ranging from mild to severe, in which concentrations of alpha lipoproteins or high-density lipoprotein (HDL) are reduced.
1 People with high blood triglycerides usually also have lower HDL cholesterol. 2  Genetic factors, type 2 diabetes, smoking, being overweight and being sedentary can all result in lower HDL cholesterol. 3  Triglycerides. 4  Triglyceride is the most common type of fat in the body.