Asker's rating. 1  Shackles are brackets installed on the rear leaf springs it causes the rear of the car to be raised giving the car that classic Muscle look. 2  useing a larger shackle will raise the rear of the car allowing slightly bigger tires in the rear. 3  Shackled Means.
Clinical Significance. A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor.
The presence of HSV-1 or HSV-2 IgM antibodies indicates an active or recent infection. HSV-1 or HSV-2 IgG antibodies indicate a previous infection. A significant increase in HSV IgG antibodies, measured by comparing acute and convalescent samples, indicates an active or recent infection.