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Early signs and symptoms of ALS include: 1  Difficulty walking or doing your normal daily activities. 2  Tripping and falling. 3  Weakness in your leg, feet or ankles.  Hand weakness or 1  clumsiness. Slurred speech or trouble swallowing.  Muscle cramps and twitching in your arms, shoulders and 1  tongue. Difficulty holding your head up or keeping good posture.
Colon Cancer Early Symptoms. Unfortunately, in most cases of colon cancer, early symptoms do not occur. Signs and symptoms generally develop only after the disease has spread beyond its earliest, most treatable stages. Once symptoms do appear, they may include blood in the stool, abdominal discomfort, and change in frequency of bowel movements.