Although an MSI-H result is the hallmark of Lynch syndrome, it is also found in 10% to 15% of sporadic CRC cases. Since MSI results do not rule out Lynch syndrome, MMR gene mutation testing should be considered regardless of MSI status in families with a strong suspicion of Lynch syndrome.
Many of the symptoms of prolactinoma are caused by an excessive amount of prolactin in the blood (hyperprolactinemia) which decreases the ovarian and testicular function. In women, prolactinoma is characterized by irregular menstrual periods, infertility and production of breast milk in women who are not pregnant (galactorrhea).
Effects of High Prolactin Levels on Men and Women. In hyperprolactinemia, both men and women will report breast enlargement due to the action of prolactin.This is known as gynecomastia in men. Apart from the effect of prolactin on the breast tissue, it can also suppress another important hormone in the body â gonadotropin-releasing hormone (GnRH).