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In the cell membrane, hydrophilic heads orient to the inside and outside of the membrane, with the hydrophobic molecules inside. This gives the membrane its semi permeable fluid nature.he hydrophilic region in the cell is water-loving and it  attracts the water molecules. It is basically composed of polar  groups which readily dissolve and absorb water.
Hydrophilic (Water loving) compound are polar in nature. They will tend to have a function group that causes an uneven electron density and hence makes it have a dipole movement. Lipophilic, (fat loving) compounds are non-polar in nature. They will tend to have long hydrocarbon chains.