It was once believed that lactic acid build-up was the cause of muscle fatigue. The assumption was lactic acid had a pickling effect on muscles, inhibiting their ability to contract. The impact of lactic acid on performance is now uncertain, it may assist or hinder muscle fatigue.
Pioglitazone is an anti-diabetic drug (thiazolidinedione-type, also called glitazones) used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar.
Pioglitazone drugs are sold as a single-ingredient product under the brand name Actos and are also sold in combination with metformin as Actoplus Met (pioglitazone/metformin), Actoplus Met XR (pioglitazone/metformin extended-release), and DueTact (pioglitazone/glimepiride). 1  The complete Actos portfolio of drugs includes the following: 1  ActoPlus Met (active ingredient: metformin hydrochloride; pioglitazone hydrochloride) 2  ActoPlus Met XR (active ingredient: metformin hydrochloride; pioglitazone hydrochloride extended release) 3  Actos (active ingredient: pioglitazone hydrochloride)