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In the cell membrane, hydrophilic heads orient to the inside and outside of the membrane, with the hydrophobic molecules inside. This gives the membrane its semi permeable fluid nature.he hydrophilic region in the cell is water-loving and it  attracts the water molecules. It is basically composed of polar  groups which readily dissolve and absorb water.
The hydrophilic head is polar and likes to come into contact with an aqueous phase. The hydrophobic tail is nonâpolar and resists interactions with an aqueous phase. Anionic surfactants are the most widely used, accounting for 50 â 60% of all applications (Salager 2002).