Asker's rating. 1  Shackles are brackets installed on the rear leaf springs it causes the rear of the car to be raised giving the car that classic Muscle look. 2  useing a larger shackle will raise the rear of the car allowing slightly bigger tires in the rear. 3  Shackled Means.
Clinical Significance. A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor.
To determine if IgM antibody is true antibody, the serum is absorbed with anti-human IgG antibody (Gullsorb test) to remove IgG prior to testing for IgM. A concurrent test with PBS in place of Gullsorb is the control. Table 2 shows examples of tests with MIF IgM-positive patient sera.