Although an MSI-H result is the hallmark of Lynch syndrome, it is also found in 10% to 15% of sporadic CRC cases. Since MSI results do not rule out Lynch syndrome, MMR gene mutation testing should be considered regardless of MSI status in families with a strong suspicion of Lynch syndrome.
Many of the symptoms of prolactinoma are caused by an excessive amount of prolactin in the blood (hyperprolactinemia) which decreases the ovarian and testicular function. In women, prolactinoma is characterized by irregular menstrual periods, infertility and production of breast milk in women who are not pregnant (galactorrhea).
A prolactinoma is a benign (noncancerous) tumor of the pituitary gland, which produces a hormone called prolactin.A prolactinoma is the most common type of pituitary tumor. Symptoms are caused by too much prolactin in the blood (a condition called hyperprolactinemia) or by pressure of the tumor on surrounding tissues. prolactinoma is a benign (noncancerous) tumor of the pituitary gland, which produces a hormone called prolactin.