Pain in the ankle can result from inflammation or injury to any of the structures in this region, including the bones, joint space, cartilage, ligaments, tendons, or muscles. Ankle pain can be associated with other symptoms including.
People with Down syndrome may have some or all of these physical characteristics: a small chin, slanted eyes, poor muscle tone, a flat nasal bridge, a single crease of the palm, and a protruding tongue due to a small mouth and relatively large tongue.
The most common features associated with Downâs syndrome include: 1  Reduced muscle tone (babies appear âfloppyâ). 2  Flat facial features, with a small nose. 3  Upward slant to the eyes. 4  Small vertical skin folds on the inner corner of the eyes. 5  Small, abnormally shaped ears. 6  Single deep crease across the centre of the palm.