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Talk with your doctor about what is best for you. 1  If you are between ages 21 and 29, you should get a Pap test every 3 years.  If you are between ages 30 and 64, you should get a Pap test and human papillomavirus (HPV) test together every 5 years or a Pap test alone every 3 years.
Women should have a Pap smear in the middle of their monthly cycle, or about 10-20 days after the LMP (last menstrual period) began. At least 2 days before the test, women should avoid having anything in the vagina including sexual intercourse, douching, vaginal creams/suppositories, or spermicide.