Although an MSI-H result is the hallmark of Lynch syndrome, it is also found in 10% to 15% of sporadic CRC cases. Since MSI results do not rule out Lynch syndrome, MMR gene mutation testing should be considered regardless of MSI status in families with a strong suspicion of Lynch syndrome.
Many of the symptoms of prolactinoma are caused by an excessive amount of prolactin in the blood (hyperprolactinemia) which decreases the ovarian and testicular function. In women, prolactinoma is characterized by irregular menstrual periods, infertility and production of breast milk in women who are not pregnant (galactorrhea).
Best Answer: CONCLUSION: Weight gain and elevated body weight are frequently associated with prolactinomas regardless of a mass effect on the hypothalamus or pituitary function. In this series, weight loss was recorded in 70% of prolactinomas patients and in 90% of male patients who normalized their prolactin levels. We propose the inclusion of hyperprolactinaemia in the differential diagnosis of endocrine obesity and weight gain.