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Early signs and symptoms of ALS include: 1  Difficulty walking or doing your normal daily activities. 2  Tripping and falling. 3  Weakness in your leg, feet or ankles.  Hand weakness or 1  clumsiness. Slurred speech or trouble swallowing.  Muscle cramps and twitching in your arms, shoulders and 1  tongue. Difficulty holding your head up or keeping good posture.
Early symptoms of Lou Gehrig's disease, also known as ALS, include muscle weakness in the hands, arms or legs, twitching of the muscles and difficulty projecting the voice, describes the ALS Association. In more advanced stages, patients have trouble swallowing and breathing, and often feel short of breath.