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Low levels of high-density lipoprotein cholesterol (HDL), or hypoalphalipoproteinemia (HA), includes a variety of conditions, ranging from mild to severe, in which concentrations of alpha lipoproteins or high-density lipoprotein (HDL) are reduced.
Itâs harder to increase HDL or good cholesterol than it is to lower LDL or total cholesterol. Itâs estimated that up to 80 percent of the variation in HDL from person to person is due to genetic factors.