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In the cell membrane, hydrophilic heads orient to the inside and outside of the membrane, with the hydrophobic molecules inside. This gives the membrane its semi permeable fluid nature.he hydrophilic region in the cell is water-loving and it  attracts the water molecules. It is basically composed of polar  groups which readily dissolve and absorb water.
Structure. Phospholipids are composed of two fatty acid tails attached to a glycerol head, according to Biology: Concepts and Connections.. The glycerol attaches to a phosphate group. The head is hydrophillic, meaning it's attracted to water.The tail is hydrophobic, or resistant to water.hospholipids are composed of two fatty acid tails attached to a glycerol head, according to Biology: Concepts and Connections.. The glycerol attaches to a phosphate group. The head is hydrophillic, meaning it's attracted to water. The tail is hydrophobic, or resistant to water.