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Contraindications include current, past or suspected breast cancer, known or suspected estrogen-dependent malignant tumours, previous idiopathic or current venous thromboembolism, known coronary heart disease, and porphyria cutanea tarda (absolute contraindication).
CONTRAINDICATIONS. COUMADIN is contraindicated in: Pregnancy; COUMADIN is contraindicated in women who are pregnant except in pregnant women with mechanical heart valves, who are at high risk of thromboembolism [see WARNINGS AND PRECAUTIONS and Use In Specific Populations]. COUMADIN can cause fetal harm when administered to a pregnant woman. While COUMADIN is contraindicated during pregnancy, the potential benefits of using COUMADIN may outweigh the risks for pregnant women with mechanical heart valves at high risk of thromboembolism.