It was once believed that lactic acid build-up was the cause of muscle fatigue. The assumption was lactic acid had a pickling effect on muscles, inhibiting their ability to contract. The impact of lactic acid on performance is now uncertain, it may assist or hinder muscle fatigue.
Pioglitazone is an anti-diabetic drug (thiazolidinedione-type, also called glitazones) used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar.
Although thiazolidinedione products may be effective for controlling blood sugar levels, these drugs have been linked to potentially serious heart complications. Rosiglitazone and pioglitazone are the two drugs in the thiazolidinedione class, and both have received black box warnings from the FDA. These warnings state that these products can increase the risk for heart failure and may cause or exacerbate heart failure symptoms.