Although an MSI-H result is the hallmark of Lynch syndrome, it is also found in 10% to 15% of sporadic CRC cases. Since MSI results do not rule out Lynch syndrome, MMR gene mutation testing should be considered regardless of MSI status in families with a strong suspicion of Lynch syndrome.
Many of the symptoms of prolactinoma are caused by an excessive amount of prolactin in the blood (hyperprolactinemia) which decreases the ovarian and testicular function. In women, prolactinoma is characterized by irregular menstrual periods, infertility and production of breast milk in women who are not pregnant (galactorrhea).
women and 42%â47% of men taking antipsychotic medications have hyperprolactinemia3. The effect of antipsychotics on prolactin appears to be dose-related. Table 2: Antipsychotic Effect on Prolactin3,4,5 The increase of prolactin can begin as early as a few hours after a dose and persists