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Early signs and symptoms of ALS include: 1  Difficulty walking or doing your normal daily activities. 2  Tripping and falling. 3  Weakness in your leg, feet or ankles.  Hand weakness or 1  clumsiness. Slurred speech or trouble swallowing.  Muscle cramps and twitching in your arms, shoulders and 1  tongue. Difficulty holding your head up or keeping good posture.
Over many years the condition gets worse, and there are lots of symptoms that come with it. Here are the 10 most common symptoms that people with ALS experience. 1. Twitching. One of the first signs that you might have ALS will be twitching. The twitching occurs as a result of cells in the spinal cord and the brain not being able to transmit signals properly, resulting in some parts of the body beginning to twitch.