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Early signs and symptoms of ALS include: 1  Difficulty walking or doing your normal daily activities. 2  Tripping and falling. 3  Weakness in your leg, feet or ankles.  Hand weakness or 1  clumsiness. Slurred speech or trouble swallowing.  Muscle cramps and twitching in your arms, shoulders and 1  tongue. Difficulty holding your head up or keeping good posture.
Over a hundred different types of liver disease are currently known to exist and symptoms can vary widely depending on whether a patient has hepatitis, alcoholic liver disease, fatty liver disease or cirrhosis, for example. Furthermore, symptoms are not always obvious in the early stages of liver disease.Symptoms can be mild and non-specific such as a loss of appetite, fatigue, general malaise, nausea and vomiting or weight loss.Such symptoms may therefore easily be overlooked in a patient with early stage disease.iver disease symptoms. By Sally Robertson, BSc. The liver is a large, reddish-brown organ that sits mainly in the upper right portion of the abdomen above the stomach and below the diaphragm. Weighing around 1.3 kg in females and 1.8 kg in males, the liver is the largest solid organ in the body.