Although an MSI-H result is the hallmark of Lynch syndrome, it is also found in 10% to 15% of sporadic CRC cases. Since MSI results do not rule out Lynch syndrome, MMR gene mutation testing should be considered regardless of MSI status in families with a strong suspicion of Lynch syndrome.
Many of the symptoms of prolactinoma are caused by an excessive amount of prolactin in the blood (hyperprolactinemia) which decreases the ovarian and testicular function. In women, prolactinoma is characterized by irregular menstrual periods, infertility and production of breast milk in women who are not pregnant (galactorrhea).
These high prolactin levels are often caused by prolactinoma, which causes a tumor to grow on your pituitary gland. This tumor then excretes excess prolactin in your body. Rarely, liver disease, kidney disease, polycystic ovary syndrome (PCOS), shingles or hypothyroidism may cause high levels of prolactin.