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In the cell membrane, hydrophilic heads orient to the inside and outside of the membrane, with the hydrophobic molecules inside. This gives the membrane its semi permeable fluid nature.he hydrophilic region in the cell is water-loving and it  attracts the water molecules. It is basically composed of polar  groups which readily dissolve and absorb water.
Best Answer: &nbsp Phospholipids have a hydrophobic tail, and a hydrophilic head. Hydrophilic means water loving, hydrophobic means water hating. The cell membrane is made up of a phospholipid bilayer (two layers). The hydrophilic tails aggregate together leaving the heads (which are water loving) to stick out.n the fluid mosaic model of a cells membrane, proteins are bobbing through a fluid bilayer of phospholipids. Nonpolar molecules such as hydrocarbons, carbon dioxide, and oxygen, are hydrophobic and can therefore dissolve in the lipid bilayer membrane (the hydrophobic middle) and can pass it easily.