It was once believed that lactic acid build-up was the cause of muscle fatigue. The assumption was lactic acid had a pickling effect on muscles, inhibiting their ability to contract. The impact of lactic acid on performance is now uncertain, it may assist or hinder muscle fatigue.
Pioglitazone is an anti-diabetic drug (thiazolidinedione-type, also called glitazones) used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar.
Thiazolidinedione antidiabetics such as pioglitazone may cause or worsen heart failure in some patients. Tell your doctor if you have a history of heart failure. Pioglitazone should not be used to treat patients with moderate to severe heart failure. You will be monitored for signs of heart failure when you start pioglitazone and when your dose increases.