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In many cases the knot in the muscle is caused by an abnormal nerve message being sent to the muscle. The abnormal nerve message is, in turn, caused by a misaligned bone in the spine that irritates the nerve. To keep it simple.
Since the muscles are not designed to be under constant stress, it is extremely essential that the stress or load is taken off as the muscles relax in the passive mode. If any activity acts as a trigger and causes the neck muscles to stay under constant tension, one is most likely to develop tension knots. Though some practitioners cite the accumulation of abnormal protein deposits within the muscle tissue as the triggering factor behind the development of muscle knots in the neck area, this theory has not been corroborated by medical research.