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Early signs and symptoms of ALS include: 1  Difficulty walking or doing your normal daily activities. 2  Tripping and falling. 3  Weakness in your leg, feet or ankles.  Hand weakness or 1  clumsiness. Slurred speech or trouble swallowing.  Muscle cramps and twitching in your arms, shoulders and 1  tongue. Difficulty holding your head up or keeping good posture.
Signs and Symptoms of Liver Disease. Early signs of liver disease often include general gastrointestinal complaints that commonly are associated with many other conditions. In some cases, early liver disease symptoms are not noticeable. General symptoms of liver disease include the following:1  Abdominal pain (located on the right side of the body, beneath the ribs). 2  Abnormal stools. 3  Flu-like symptoms (e.g., fatigue, nausea, vomiting, muscle or joint pain, fever).4  Loss of appetite.igns and Symptoms of Liver Disease. Early signs of liver disease often include general gastrointestinal complaints that commonly are associated with many other conditions. In some cases, early liver disease symptoms are not noticeable. General symptoms of liver disease include the following: