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MedPage Today Senior Writer. TORONTO, April 20 - A single oral dose of the antiemetic Zofran (ondansetron) can reduce vomiting by more than half and facilitate oral rehydration in children with gastroenteritis, according to pediatric emergency researchers.herefore it may be useful therapy in an emergency department for children with vomiting and mild-to-moderate dehydration as a result of gastroenteritis, they concluded. This study was supported by grants from the National Institutes of Health and GlaxoSmithKline, Zofran's maker.
Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Zofran is available in generic form. Common side effects of Zofran include: diarrhea, headache, fever, lightheadedness, dizziness, weakness, tiredness, drowsiness, constipation, rash, blurred vision, and; muscle spasm. Zofran adult dose is 32-mg given as a single dose or divided in three 0.15-mg/kg divided doses infused over 15 minutes.