The central volume of distribution (Vc) is a hypothetical volume into which a drug initially distributes upon administration. This compartment can be thought of as the blood in vessels and tissues which are highly perfused by blood. The peripheral volume is the sum of all tissue spaces outside the central compartment.
Knot Note: Start thinking about bridesmaid dresses about six months before your wedding to allow enough time to decide on, order, and fit the dresses. It takes two to three months for the dresses to arrive, and four to six weeks for alterations.
Plan Ahead. Gather your bridesmaids and choose the desired dresses roughly six months before your wedding. Once you order the dresses, it can take as long as three months for them to arrive. When the shop receives the dresses, arrange a day for you and your bridesmaids to meet for the dress fittings. Accounting for the potential for delays and the necessity of second fittings, expect up to six weeks to have the garments altered. Each of your bridesmaids should have her dress ready about six weeks before the wedding.