In post-marketing clinical studies, pitavastatin reduced LDL, Total Cholesterol (TC), non-HDL cholesterol and Apolipoprotein B (ApoB) by 26.2-48%, 16.6-37%, 22.5-45%, and 17.4-41%, respectively. Its effects on HDL and triglycerides varied and ranged from -6.9% to 17.8%, and -46% up to an increase of 21%, respectively.
Cats can have their first heat cycle between 4-6 months of age and will go in to heat approximately 3 times a year. Each litter typically has between 4 and 6 kittens. Dogs go into heat at about 4-6 months of age and typically have two heat cycles per year. Each litter has, on average, between 4 and 10 puppies. A dogâs heat cycle lasts a total of 30 days. The vagina will swell during the first 10 days. There will be bloody discharge during the next 10 days.
Research over the last 15 years with animal shelters has shown that younger animals actually recover faster from modern anesthesia. She absolutely should be spayed before her first heat. First heat typically occurs between 6-9 months of age, though a few dogs can have a heat as early as 5 months. So as early as your vet will do it is best. There is absolutely no benefit to your dog having a heat cycle; in fact, risk of reproductive cancer increases with every heat cycle a dog has.