Adult Studies: In a double-blind study of three different dosing regimens of ZOFRAN Injection, 0.015 mg/kg, 0.15 mg/kg, and 0.30 mg/kg, each given three times during the course of cancer chemotherapy, the 0.15-mg/kg dosing regimen was more effective than the 0.015-mg/kg dosing regimen.
Peristaltic movement comprises relaxation of circular smooth muscles, then their contraction behind the chewed material to keep it from moving backward, then longitudinal contraction to push it forward. Earthworms use a similar mechanism to drive their locomotion, and some modern machinery imitates this design.
During peristalsis, the longitudinal muscles within the small intestine wall contract, and then the circular muscles contract, pushing the food down the tract. This coordinated contraction of smooth muscle keeps food moving on its one-way path through your digestive system.