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median lethal dose (LD 50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.ee also median effective dose. erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening). fatal dose lethal dose.
Main article: Median lethal dose. The median lethal dose, LD 50 (abbreviation for  lethal dose, 50%), LC 50 (lethal concentration, 50%) or LCt 50 (lethal concentration and time) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after a specified test duration.ecause resistance varies from one individual to another, the lethal dose represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given percentage of subjects will die. The lethal concentration is a lethal dose measurement used for gases or particulates.