Adult Studies: In a double-blind study of three different dosing regimens of ZOFRAN Injection, 0.015 mg/kg, 0.15 mg/kg, and 0.30 mg/kg, each given three times during the course of cancer chemotherapy, the 0.15-mg/kg dosing regimen was more effective than the 0.015-mg/kg dosing regimen.
Peristaltic movement comprises relaxation of circular smooth muscles, then their contraction behind the chewed material to keep it from moving backward, then longitudinal contraction to push it forward. Earthworms use a similar mechanism to drive their locomotion, and some modern machinery imitates this design.
Peristalsis is a distinctive pattern of smooth muscle contractions that propels foodstuffs distally through the esophagus and intestines. One group of interneurons activates excitatory motor neurons above the bolus-these neurons, which contain acetylcholine and substance P, stimulate contraction of smooth muscle above the bolus. 2  Another group of interneurons activates inhibitory motor neurons that stimulate relaxation of smooth muscle below the bolus.