Adult Studies: In a double-blind study of three different dosing regimens of ZOFRAN Injection, 0.015 mg/kg, 0.15 mg/kg, and 0.30 mg/kg, each given three times during the course of cancer chemotherapy, the 0.15-mg/kg dosing regimen was more effective than the 0.015-mg/kg dosing regimen.
Peristaltic movement comprises relaxation of circular smooth muscles, then their contraction behind the chewed material to keep it from moving backward, then longitudinal contraction to push it forward. Earthworms use a similar mechanism to drive their locomotion, and some modern machinery imitates this design.
Control of Movement through the Small Intestine. A number of hormonal and nervous factors initiate and maintain peristalsis and mixing. Nerve impulses which travel throughout the small intestine are triggered by the gastroenteric reflex (refer to Defecation Reflex) and localized distention of the duodenum.