Degenerative disc disease is not genetic. Inheritance of Degenerative Disc Disease refers to whether the condition is inherited from your parents or runs in families. The level of inheritance of a condition depends on how important genetics are to the disease.
Bone fractures, particularly in the spine or hip, are the most serious complication of osteoporosis. Hip fractures often are caused by a fall and can result in disability and even an increased risk of death within the first year after the injury. In some cases, spinal fractures can occur even if you haven't fallen.
Cushing's disease, the over production of cortisol, can also cause osteoporosis. A recent study in mice showed 23 to 27% reduction in femur bone mass in animals with TBI twelve-weeks earlier. The findings indicate that TBI itself, with or without pituitary injury, can and does lead to bone loss. More research needs to be done.