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Enteroendocrine cells of the intestine are the most numerous endocrine cells of the body. They constitute an enteric endocrine system as a subset of the endocrine system just as the enteric nervous system is a subset of the nervous system.
The enteroendocrine cells are those endocrine cells that are located in the gastrointestinal system. They produce hormones and other signaling molecules that act on the brain and other parts of the body, in response to environmental changes in the digestive tract.