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The result is an increase in the heart rate. Conversely, stimulating the parasympathetic nervous system (vagal nerves to the heart) increases the resting potential and decreases the rate of diastolic depolarization; under these circumstances the heart rate slows. The...
Clinical Effects on the Peripheral Nervous System Due to Excessive Stimulation of Muscarinic Receptors. Excessive Stimulation of muscarinic receptors due to cholinesterase inhibitor poisoning results in increased parasympathetic: (Erdman 2004). 1  Cardiac effects. 2  AV blocks, with escape rhythms.