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How long does a BOTOXÂ® injection last? You can expect the effect of your BOTOXÂ® treatment to last anywhere from four to six months. As acetylcholine production returns to normal, your muscles will once again begin to contract and the wrinkles will reappear. That's the bad news. The good news is that your wrinkles may be less prominent after BOTOXÂ® treatment because your muscles may be somewhat trained to be in the more relaxed state. As the wrinkles reappear, you will have to have repeat BOTOXÂ® treatments to get them to disappear again.
The injections take about 10 minutes, and you should have no downtime afterward. Normally you would see improvement within a few days. Botox requires two to four days for it to attach to the nerve ending that would normally stimulate the muscle to contract. The maximum effect usually occurs at about 10-14 days. Therefore, whatever effect is obtained two weeks after the injections should be considered the maximum effect that is going to occur.