Adult Studies: In a double-blind study of three different dosing regimens of ZOFRAN Injection, 0.015 mg/kg, 0.15 mg/kg, and 0.30 mg/kg, each given three times during the course of cancer chemotherapy, the 0.15-mg/kg dosing regimen was more effective than the 0.015-mg/kg dosing regimen.
Peristaltic movement comprises relaxation of circular smooth muscles, then their contraction behind the chewed material to keep it from moving backward, then longitudinal contraction to push it forward. Earthworms use a similar mechanism to drive their locomotion, and some modern machinery imitates this design.
The wavelike contractions of the smooth muscle in the gastrointestinal system are called peristalsis. The purpose of peristalsis is to push boluses of food along the gastrointestinal tract. This is achieved by the waves of contractions in the smooth muscle followed by relaxation of the muscles, pushing the bolus (ball of food) a bit further along the digestive tract with each contraction. These contractions move food or chyme through the esophagus, and intestines.