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Several other conditions can cause them to form. Burns are probably the second most frequent cause of water blisters. Second and third degree burns may quickly blister. Since burns of this type can cause damage to the skin, they usually require treatment with topical antibiotics to prevent infection.
They're bubbles that pop up when fluid collects in pockets under the top layer of your skin. They can be filled with pus, blood, or the clear, watery part of your blood called serum. Most are shaped like circles. Depending on the cause, your blister could itch or hurt a lot or a little. They can appear as a single bubble or in clusters.