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Enteroendocrine cells of the intestine are the most numerous endocrine cells of the body. They constitute an enteric endocrine system as a subset of the endocrine system just as the enteric nervous system is a subset of the nervous system.
Enteroendocrine cells comprise a class of columnar epithelial cells, scattered individually among the absorptive cells and exocrine cells that line the mucosa of the GI tract. They are located most commonly in the necks and deeper in gastric glands and in the lower portions of intestinal crypts.