A small carriage propelled by a steam turbine powered engine was apparently invented by Ferdinand Verbiest, a Belgian, in 1672 while in China. It is argued that this constitutes the first 'car' ever invented, but the design was only 65cm long, had no seats or pilot controls, and was intended as little more than a toy.
In bipolar disorder, mixed state is a condition during which symptoms of both mania and depression occur simultaneously. Individuals experiencing a mixed state may have manic symptoms such as grandiose thoughts while simultaneously experiencing depressive symptoms such as excessive guilt or feeling suicidal.
Treatment for bipolar disorder, formerly called manic depression, generally involves medications and mental health counseling (psychotherapy) â whether you have bipolar I or bipolar II. Bipolar II disorder is not a milder form of bipolar I disorder, but a separate diagnosis. Other types of therapy also may help. 2  Substance abuse treatment. 3  Many people with bipolar disorder also have alcohol, tobacco or drug problems. 4  Drugs or alcohol may seem to ease symptoms, but they can actually trigger, prolong or worsen depression or mania.