Adult Studies: In a double-blind study of three different dosing regimens of ZOFRAN Injection, 0.015 mg/kg, 0.15 mg/kg, and 0.30 mg/kg, each given three times during the course of cancer chemotherapy, the 0.15-mg/kg dosing regimen was more effective than the 0.015-mg/kg dosing regimen.
Peristaltic movement comprises relaxation of circular smooth muscles, then their contraction behind the chewed material to keep it from moving backward, then longitudinal contraction to push it forward. Earthworms use a similar mechanism to drive their locomotion, and some modern machinery imitates this design.
In the large intestine, peristalsis occurs once every 30 minutes. A strong, sustained wave of peristalsis occurs in the colon two or three times a day (usually after a meal), which forces the waste material into the last part of the large intestine (the rectum) and prompts the urge to poop.