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Blood disorders can affect any of the three main components of blood: 1  Red blood cells, which carry oxygen to the body's tissues. 2  White blood cells, which fight infections. 3  Platelets, which help blood to clot.
Blood Clots: Plugging the Breaks. When an injury causes a blood vessel wall to break, platelets are activated. They change shape from round to spiny, stick to the broken vessel wall and each other, and begin to plug the break. They also interact with other blood proteins to form fibrin. Fibrin strands form a net that entraps more platelets and blood cells, producing a clot that plugs the break. Formation of a clot also involves activation of a sequence of blood clotting factors that generate thrombin.