A small carriage propelled by a steam turbine powered engine was apparently invented by Ferdinand Verbiest, a Belgian, in 1672 while in China. It is argued that this constitutes the first 'car' ever invented, but the design was only 65cm long, had no seats or pilot controls, and was intended as little more than a toy.
In bipolar disorder, mixed state is a condition during which symptoms of both mania and depression occur simultaneously. Individuals experiencing a mixed state may have manic symptoms such as grandiose thoughts while simultaneously experiencing depressive symptoms such as excessive guilt or feeling suicidal.
Medications for Depression and Bipolar Disorder. Your health care provider (HCP) might prescribe one or more medications to treat your symptoms. These may include: 1  Mood stabilizers. 2  These medications help even out your highs and lows. 3  Antidepressants. 4  These medications help lift the symptoms of depression. 5  Antipsychotics. 6  These medications are primarily used to treat symptoms of mania.