In post-marketing clinical studies, pitavastatin reduced LDL, Total Cholesterol (TC), non-HDL cholesterol and Apolipoprotein B (ApoB) by 26.2-48%, 16.6-37%, 22.5-45%, and 17.4-41%, respectively. Its effects on HDL and triglycerides varied and ranged from -6.9% to 17.8%, and -46% up to an increase of 21%, respectively.
Cats can have their first heat cycle between 4-6 months of age and will go in to heat approximately 3 times a year. Each litter typically has between 4 and 6 kittens. Dogs go into heat at about 4-6 months of age and typically have two heat cycles per year. Each litter has, on average, between 4 and 10 puppies. A dogâs heat cycle lasts a total of 30 days. The vagina will swell during the first 10 days. There will be bloody discharge during the next 10 days.
Many times the dog's heat cycle, better known as estrous cycle, seems to be quite unpredictable. The first heat generally occurs around six months in small, medium dogs and around 12-18 months in larger breed dogs. However, It is not unheard of some giant dog breeds going into heat at around 30 months of age.