Adult Studies: In a double-blind study of three different dosing regimens of ZOFRAN Injection, 0.015 mg/kg, 0.15 mg/kg, and 0.30 mg/kg, each given three times during the course of cancer chemotherapy, the 0.15-mg/kg dosing regimen was more effective than the 0.015-mg/kg dosing regimen.
Peristaltic movement comprises relaxation of circular smooth muscles, then their contraction behind the chewed material to keep it from moving backward, then longitudinal contraction to push it forward. Earthworms use a similar mechanism to drive their locomotion, and some modern machinery imitates this design.
1 Swallow-induced peristalsis is called primary peristalsis, and the peristalsis elicited by esophageal distention is called secondary peristalsis. 2  Peristaltic contractions are always preceded by inhibition that, in the case of primary peristalsis, is called deglutitive inhibition.he main function of the esophagus is to propel swallowed food or fluid into the stomach. This occurs through sequential or peristaltic contraction of circular muscle in the esophageal body, in concert with appropriately timed relaxation of the upper and lower esophageal sphincters.