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Blood disorders can affect any of the three main components of blood: 1  Red blood cells, which carry oxygen to the body's tissues. 2  White blood cells, which fight infections. 3  Platelets, which help blood to clot.
Abnormal blood clotting: Anything that interferes with blood clotting can lead to nosebleeds. Medications, even common ones like aspirin, can alter the blood-clotting mechanism just enough to cause bleeding. Blood diseases, such as hemophilia, also can provoke nosebleeds.