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By 1916, over half of the U.S. states already had statutes that prohibited alcohol. In 1919, the 18th Amendment to the U.S. Constitution, which prohibited the sale and manufacture of alcohol, was ratified. It went into effect on January 16, 1920.
View the Answer. 18th Amendment to the Constitution. Ratified in 1919, the 18th Amendment made it illegal to manufacture, transport, and sell alcoholic beverages. As a result, the 1920s are often referred to as the Prohibition Era. The failure of the amendment (it was repealed in 1933) to curb the use of alcohol is one of the facts many individuals nowadays point to when debating in favor of legalizing drugs.