Dental Crowns (Dental Caps) Steven B. Horne, DDS. Dr. Steve Horne began his career at Brigham Young University obtaining his BA in English. He earned his Doctorate of Dental Surgery in 2007 from the University of Southern California where his pursuit for academic excellence landed him on the Dean's List.
Clinical pharmacokinetics is theapplication of pharmacokinetic principles to the safeand effective therapeutic management of drugs in anindividual patient.Primary goals of clinical pharmacokinetics includeenhancing efï¬cacy and decreasing toxicity of a patientâsdrug therapy.
Pharmacodynamics, with pharmacokinetics (what the body does to a drugâsee Pharmacokinetics), helps explain the relationship between the dose and response, ie, the drug's effects. The pharmacologic response depends on the drug binding to its target. The concentration of the drug at the receptor site influences the drugâs effect. A drugâs pharmacodynamics can be affected by physiologic changes due to disorders, aging, or other drugs. Disorders that affect pharmacodynamic responses include genetic mutations, thyrotoxicosis, malnutrition, myasthenia gravis, Parkinson disease, and some forms of insulin -resistant diabetes mellitus.