The Costa Concordia was only hours into a cruise of the Mediterranean on Friday 13 January 2012 when disaster struck just off Giglio island. The huge vessel - which had more than 4,000 passenger and crew onboard - then lost power, drifted and partially capsized.
The recommended dose range for metoprolol [succinate] for treating hypertension in adults is 25 to 100 mg once a day. The recommended dose range for metoprolol [succinate] for treating hypertension in children (6 years of age or older) is 0.1 mg/kg to 50 mg once a day.
Each patientâs dose was titrated progressively from 6.25 mg of carvedilol twice daily and 50 mg of metoprolol twice daily to a maximum dose of 25 mg and 200 mg twice daily, respectively, at 1- to 2-week intervals toward target BP levels for a total of 2 to 7 weeks.nterventions Participants were randomized to receive a 6.25- to 25-mg dose of carvedilol (n = 498) or 50- to 200-mg dose of metoprolol tartrate (n = 737), each twice daily. Open-label hydrochlorothiazide and a dihydropyridine calcium antagonist were added, if needed, to achieve blood pressure target.