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In summary, the new oral anticoagulants represent a giant step forward in the quest to replace warfarin. In addition to their enhanced convenience, the new agents are not only safer than warfarin because of the reduced risk of intracranial bleeding, but they also have the potential to be more effective.
Looking at the pros and cons of new oral anticoagulants and whether there is a difference between the available agents. Table 1: A comparison of advantages with newer anticoagulants. Warfarin is the anticoagulant of choice for mechanical valves, left ventricular thrombi and patients with CrCl < 30ml/min.