Overdose: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: unusual excitement, fast/irregular heartbeat, seizures.
Natural Variation Natural variation includes internal and external variability influences such as the solar Schwabe cycle, oceanic cycles, seasonal influences based on changes caused by the interaction of the various natural oscillations in the climate system.
As for natural versus artificial, the FDA says that a natural flavor is one that's derived from a spice, fruit or fruit juice, vegetable or vegetable juice, edible yeast, herb, bark, bud, root, leaf or similar plant material, meat, seafood, poultry, eggs, dairy products, or fermentation products thereof..