Efficacy is diminished and risk of ototoxicity increased in patients with hypoproteinemia (associated with nephrotic syndrome); ototoxicity is associated with rapid injection, severe renal impairment, use of higher than recommended doses, concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs.
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The Chief Public Health Officer (CPHO) is the federal government's lead public health professional. The CPHO is responsible for: 1  Providing advice to the Minister of Health and President of the Public Health Agency of Canada on health issues;  Working with other governments, jurisdictions, agencies, organizations, and countries on health matters;