The origin of the metaphor is the prohibition of putting a stumbling block before the blind (Leviticus 19:14). Geoffrey W. Bromiley calls the image especially appropriate to a rocky land like Palestine. In the Hebrew Bible, the term for stumbling block is Biblical Hebrew miá¸µÅ¡Ål (×Ö´×Ö°×©××Ö¹×).
A high platelet count can be caused by cancer, infections, anemia, and inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. A high platelet count can lead to excessive, dangerous blood clotting if left untreated. The medical term for a high platelet count is thrombocytosis, a condition in which bone marrow cells produce too many platelets. Thrombocytosis can be either reactive or essential. Reactive thrombocytosis means that a high platelet count is a reaction to inflammation, infection, injury, anemia, or cancer, and essential thrombocytosis indicates that genetic conditions or hormone imbalances are causing irregular platelet formation.
MPV reflects the average size of platelets present in a person's sample of blood while PDW reflects how uniform the platelets are in size. These calculations can give the doctor additional information about platelets and/or about the cause of a high or low platelet count. Larger platelets are usually relatively young and more recently released from the bone marrow, while smaller platelets may be older and have been in circulation for a few days.