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It said that DNA was made up of four bases (adenine, thymine, guanine and cytosine) that were present in regular amounts, but that their organisation was too simple to carry hereditary information. It was Chargaff's work that overturned this.rwin Chargaff. Erwin Chargaff was working at Columbia University in New York in the 1940s when he read Oswald Avery's research about DNA being the hereditary material. From that moment in 1944 he devoted his research to working out the chemical composition of DNA.
These bacteria were lysed to release phage progeny. The progeny of the phages that were originally labeled with 32 P remained labeled, while the progeny of the phages originally labeled with 35 S were unlabeled. Thus, the HersheyâChase experiment helped confirm that DNA, not protein, is the genetic material.Hershey and Chase showed that the introduction of deoxyribonuclease (referred to as DNase), an enzyme that breaks down DNA, into a solution containing the labeled bacteriophages did not introduce any 32 P into the solution.he results of the AveryâMacLeodâMcCarty experiment, published in 1944, suggested that DNA was the genetic material, but there was still some hesitation within the general scientific community to accept this, which set the stage for the HersheyâChase experiment.