Legislative term limits have been ruled unconstitutional by the courts in four states; see Summaries of Term Limits Cases for details. See a year-by-year breakdown of the number of legislators termed out between 1996 and 2014.
A later study showed it is an effective antispasmodic when test-applied topically to the intestine during endoscopy. Bamboo shoots have been used for gastrointestinal and antispasmodic symptoms. Anisotropine, Atropine, Clidinium bromide are also the most commonly used modern antispasmodics. Skeletal muscle spasm
Antimetabolite drugs were among the first effective chemotherapeutic agents discovered and are folic acid, pyrimidine or purine analogues. They are characterized by low molecular weights. They have similar structures as naturally occurring molecules used in nucleic acid (DNA and RNA) synthesis. Antimetabolites are similar to chemicals needed for normal biochemical activity, but differ enough so that they interfere with normal cell function. Generally, antimetabolites induce cell death during the S phase of cell growth when incorporated into RNA and DNA or inhibit enzymes needed for nucleic acid production. These agents are used for a variety of cancer therapies including leukemia, breast, ovarian and gastro-intestinal cancers.