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In summary, the new oral anticoagulants represent a giant step forward in the quest to replace warfarin. In addition to their enhanced convenience, the new agents are not only safer than warfarin because of the reduced risk of intracranial bleeding, but they also have the potential to be more effective.
1 Evidence can be contradictory as to the effect of certain antibiotics on the action of warfarin. 2  A review is presented here outlining important effects that commonly prescribed antibiotics have on the action of warfarin.bstract. Warfarin is the most commonly prescribed oral anticoagulant and is used in the management of thromboembolic disease. The practitioner is regularly faced with the need to prescribe concurrent antimicrobial therapy, either as prophylactic cover or in the therapeutic management of existing infection.