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The rough endoplasmic reticulum synthesizes proteins while the function of the smooth endoplasmic reticula is to synthesize steroids and lipids; regulate calcium concentration, drug metabolism, as well as attachment of receptors on cell membrane proteins; and metabolize steroids (but not lipids) and carbohydrates.
Definition of Rough Endoplasmic Reticulum. Cellular organelles are like tiny organs found in a cell that perform specific functions like the large organs in our bodies.