5. Summary & Conclusions CBEA is a key element of enterprise systems engineering; it is the analytical framework that supports capabilities-based planning, programming, and acquisition in a systemic approach to the purposeful evolution of the enterprise.
The genes of telomerase subunits, which include TERT, TERC, DKC1 and TEP1, are located on different chromosomes. The human TERT gene (hTERT) is translated into a protein of 1132 amino acids. TERT polypeptide folds with (and carries) TERC, a non-coding RNA (451 nucleotides long).
1 Every time a cell carries out DNA replication the chromosomes are shortened by about 25-200 bases (A, C, G, or T) per replication. 2  However, because the ends are protected by telomeres, the only part of the chromosome that is lost, is the telomere, and the DNA is left undamaged. Telomerase is an enzyme that adds the TTAGGG telomere sequence to the ends of chromosomes. 2  Telomerase is only found in very low concentrations in our somatic cells. 3  Because these cells do not regularly use telomerase they age leading to a reduction in normal function.