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DHEA supplementation can increase testosterone levels quite significantly in middle-aged and older men, and in menopausal women. However, these effects are â for some reason â highly unreliable in younger guys.
Both the fall in testosterone and the shift from testosterone to DHT allows increased effect of estradiol. Male estradiol levels are equivalent to or greater than that of postmenopausal females, but normally estradiol's effects are suppressed (antagonized) by the male's greater production of testosterone. Perhaps estradiol Is also the culprit (along with DHT) in prostate growth.