Females are usually carriers because they only have one copy of the disease allele. Affected males are related through carrier females. For a carrier female, with each pregnancy there is a one in two (50%) chance her sons will inherit the disease allele and a one in two (50%) chance her daughters will be carriers.
A complimentary close, also known as a complimentary closing, is the term prior to your signature in an email message or formal letter. This sign-off phrase shows your respect and appreciation for the person who is considering the request in your letter or email.
Use the right tone. A business or formal letter should be written in a tone that is slightly more formal than your everyday language. Avoid the following: slang or jargon; contractions such as I'm, can't, it's; and vague words such as good and nice. Be polite and respectful, even if you are complaining. Take a look at our formal letter example to see what tone is appropriate.