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It said that DNA was made up of four bases (adenine, thymine, guanine and cytosine) that were present in regular amounts, but that their organisation was too simple to carry hereditary information. It was Chargaff's work that overturned this.rwin Chargaff. Erwin Chargaff was working at Columbia University in New York in the 1940s when he read Oswald Avery's research about DNA being the hereditary material. From that moment in 1944 he devoted his research to working out the chemical composition of DNA.
Plasmids have been key to the development of molecular biotechnology. They act as delivery vehicles, or vectors, to introduce foreign DNA into bacteria. Using plasmids for DNA delivery began in the 1970s when DNA from other organisms was first âcut and pastedâ into specific sites within the plasmid DNA.acterial DNA â a circular chromosome plus plasmids. The DNA of most bacteria is contained in a single circular molecule, called the bacterial chromosome. The chromosome, along with several proteins and RNA molecules, forms an irregularly shaped structure called the nucleoid.