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In summary, the new oral anticoagulants represent a giant step forward in the quest to replace warfarin. In addition to their enhanced convenience, the new agents are not only safer than warfarin because of the reduced risk of intracranial bleeding, but they also have the potential to be more effective.
In the early 1950s, warfarin was found to be effective and relatively safe for preventing thrombosis and thromboembolism in many disorders. It was approved for use as a medication in 1954, and has remained popular ever since. Warfarin is the most widely prescribed oral anticoagulant drug in North America.he major side effect of warfarin use is bleeding. Risk of bleeding is increased if the INR is out of range (due to accidental or deliberate overdose or due to interactions). Many drug interactions can increase the effect of warfarin, also causing an overdose.