5. Summary & Conclusions CBEA is a key element of enterprise systems engineering; it is the analytical framework that supports capabilities-based planning, programming, and acquisition in a systemic approach to the purposeful evolution of the enterprise.
The genes of telomerase subunits, which include TERT, TERC, DKC1 and TEP1, are located on different chromosomes. The human TERT gene (hTERT) is translated into a protein of 1132 amino acids. TERT polypeptide folds with (and carries) TERC, a non-coding RNA (451 nucleotides long).
Telomerase is a large multisubunit RNP. Telomerase is a reverse transcriptase that adds telomere repeats to chromosome ends. The minimal catalytic core is composed of TERT, the telomerase reverse transcriptase, and TERC, the telomerase RNA, which acts as the template for telomere addition.elomeres protect chromosome ends. Telomeres are TTAGGG double-stranded DNA repeats culminating in a single-stranded overhang. The shelterin protein complex protects telomeres, facilitates replication and controls access of telomerase.