They observed that delivering the immunization via the rectum was most effective and that mice that received the vaccine had significantly lower levels of C. difficile colonization.(28) (1)Kelly, C.P., LaMont, J.T. âClostridium difficile infectionâ.
Happy holidays: Booking five weeks in advance is the optimal time for cheap flights, says the study. The answer is - domestic flights are at their cheapest 54 days before takeoff, which could save travellers up to Â£190. While the worst time to book a cheap flight is last minute - with the day before departure the most expensive.
How far to book in advance: Seven weeks for domestic flights. Book 11 to 12 weeks out for international flights. The worst day to buy: Within 11 days of your flight. One day before the flight was the absolute worst. The best fares for Thanksgiving: For Thanksgiving 2012, the best day to buy was, on average, 96 days (about 14 weeks) before the flight. The bottom line: Do your homework before booking any flight, and make sure you've got the right tools to set yourself up for the best fares.