The Costa Concordia was only hours into a cruise of the Mediterranean on Friday 13 January 2012 when disaster struck just off Giglio island. The huge vessel - which had more than 4,000 passenger and crew onboard - then lost power, drifted and partially capsized.
The recommended dose range for metoprolol [succinate] for treating hypertension in adults is 25 to 100 mg once a day. The recommended dose range for metoprolol [succinate] for treating hypertension in children (6 years of age or older) is 0.1 mg/kg to 50 mg once a day.
DRUG DESCRIPTION. TOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of metoprolol for once-daily administration.