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Eye pressure test: A routine part of every routine eye exam that measures the fluid pressure inside the eye. The test is called tonometry. Increased pressure within the eye can be a sign of glaucoma, a common and potentially very serious eye problem, if it is not detected and treated promptly.
All forms of physical pressure are detectable by humans using the sense of touch. In other words, yes, humans can detect pressure. If you've ever been in a barometric chamber you can easily attest to the truth of this fact. Gradual changes in atmospheric pressure are typically undetectable.