1 People with lupus develop autoimmune antibodies that can attach to tissues throughout the body. 2  The joints, lungs, blood cells, nerves, and kidneys are commonly affected in lupus. 3  Treatment often requires daily oral prednisone, a steroid that reduces immune system function. 4  Inflammatory bowel disease (IBD). Vasculitis. 2  The immune system attacks and damages blood vessels in this group of autoimmune diseases. 3  Vasculitis can affect any organ, so symptoms vary widely and can occur almost anywhere in the body. 4  Treatment includes reducing immune system activity, usually with prednisone or another corticosteroid.
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