They observed that delivering the immunization via the rectum was most effective and that mice that received the vaccine had significantly lower levels of C. difficile colonization.(28) (1)Kelly, C.P., LaMont, J.T. âClostridium difficile infectionâ.
Happy holidays: Booking five weeks in advance is the optimal time for cheap flights, says the study. The answer is - domestic flights are at their cheapest 54 days before takeoff, which could save travellers up to Â£190. While the worst time to book a cheap flight is last minute - with the day before departure the most expensive.
âOf course, a million caveats apply, and this is all based on averages from a yearâs worth of dates in over 11,000 purely domestic markets,â CheapAir.com CEO Jeff Klee said. âFor any given flight, the actual best time to buy might vary, depending on the market, the time of year, the day of week and other factors.â. Rather unsurprisingly, the worst time to buy a ticket is the day before. Two days before is a close second, and then three days and so on until you get to 11 days out. After that, the next worst day to purchase a flight is between 208 and 210 days in advance.