(The average rate of speech for English speakers in the United States is about 150 words per minute, by the way.) A speaker's habits also influence how much air pressure is used to produce sound and how s/he uses laryngeal muscles to open and close the vocal folds.
4 Use of methotrexate to treat pregnancy of unknown location.  You may require a second dose of the drug.  You are advised to wait a minimum of 3 months before. trying for a future pregnancy.  You are sometimes more vulnerable to infection (if you. come into contact with someone with flu/common cold. etc).
Pregnant women who have psoriasis or rheumatoid arthritis must not use methotrexate. (See also Precautions section.) If you have kidney problems or excess body water (ascites, pleural effusion), you must be closely monitored and your dose may be adjusted or stopped by your doctor.