GangotriÂ© afateev/FotoliaThe Ganges rises in the southern Great Himalayas on the Indian side of the border with the Tibet Autonomous Region of China. Its five headstreamsâthe Bhagirathi, the Alaknanda, the Mandakini, the Dhauliganga, and the Pindarâall rise in the mountainous region of northern Uttarakhand state.
The signs of ototoxicity, in order of frequency, are: 1 â Development of tinnitus in one or both ears. 2 â Intensification of existing tinnitus or the appearance of a new sound. 3 â Fullness or pressure in the ears other than being caused by infection. 4 â Awareness of hearing loss in an unaffected ear or the progression of an existing loss. 5 â Development of vertigo or a spinning sensation usually aggravated by motion which may or may not be accompanied by nausea.
1. Ototoxicity -- Vestibular toxicity -- Auditory toxicity 2. Nephrotoxicity Note: Oto/nephrotoxicity are dose-dependent, cumulative, and potentiated by use of other oto/nephrotoxic drugs. Due to toxicity we reserve aminoglycosides for serious infections for which less toxic drugs don't work. Note: Toxicity can be reversible if caught early and patient is taken off aminoglycosides. 3.