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It said that DNA was made up of four bases (adenine, thymine, guanine and cytosine) that were present in regular amounts, but that their organisation was too simple to carry hereditary information. It was Chargaff's work that overturned this.rwin Chargaff. Erwin Chargaff was working at Columbia University in New York in the 1940s when he read Oswald Avery's research about DNA being the hereditary material. From that moment in 1944 he devoted his research to working out the chemical composition of DNA.
Chargaff's realization that A = T and C = G, combined with some crucially important X-ray crystallography work by English researchers Rosalind Franklin and Maurice Wilkins, contributed to Watson and Crick's derivation of the three-dimensional, double-helical model for the structure of DNA.any people believe that American biologist James Watson and English physicist Francis Crick discovered DNA in the 1950s. In reality, this is not the case. Rather, DNA was first identified in the late 1860s by Swiss chemist Friedrich Miescher.