Niacin is essential to good health. If you do not consume enough, you could develop pellagra, which is the term for niacin deficiency. The symptoms of pellagra include inflamed skin, digestive problems, mental impairment and lack of energy.
In PTV, he has a trouser malfunction at the Primetime Emmy Awards that results in intensive censoring of television by the FCC. In The Family Guy 100th Episode Special one of the people interviewed by Seth MacFarlane thought Pierce does the voice of Stewie Griffin. MacFarlane, Stewie's true voice actor, confirmed to her that Pierce does his voice so that Pierce would be thought down upon by the woman, instead of himself.
Brian was also featured, along with Stewie, in an advertisement for Wheat Thins. He and Stewie also introduced the 2007 Emmy Awards with a song which recapped the events in television, over the past year. The song was adapted from the one sung by Brian, Stewie and Peter in the Family Guy episode  PTV .