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A: Cymbalta (duloxetine) is an antidepressant called a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by altering the chemicals in your brain. Drowsiness and fatigue are two of the most common side effects of Cymbalta. If the Cymbalta is to be taken once daily, it may help to take the dose at bedtime.
Trintellix (vortioxetine) tablets are an antidepressant indicated for the treatment of major depressive disorder (MDD). Antidepressants such as Trintellix increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies.