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It said that DNA was made up of four bases (adenine, thymine, guanine and cytosine) that were present in regular amounts, but that their organisation was too simple to carry hereditary information. It was Chargaff's work that overturned this.rwin Chargaff. Erwin Chargaff was working at Columbia University in New York in the 1940s when he read Oswald Avery's research about DNA being the hereditary material. From that moment in 1944 he devoted his research to working out the chemical composition of DNA.
Chargaff's ratios, 3D animation with narration. Description: Transcript: The DNA molecule is made up of very long chains of the 4 bases: A, C, G and T. In 1950, Erwin Chargaff published a paper stating that in DNA of any given species, the ratio of adenine to thymine is equal, as is the ratio of cytosine to guanine.his is known as Chargaff's ratios and it was a crucial clue that helped solve the structure of DNA. Chargaff's ratios are universal: all forms of life obey this rule. Only the balance of A-T pairs and C-G pairs varies between species.