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Stargardt disease: An hereditary eye disease that is one of the most frequent causes of macular degeneration in childhood.targardt disease: An hereditary eye disease that is one of the most frequent causes of macular degeneration in childhood.
In rare cases--one in 20,000--macular degeneration is diagnosed in children and teenagers. Of those cases, the most common cause is Stargardt disease, named for Karl Stargardt, a German ophthalmologist who first reported a case in his practice in 1901.targardt disease is the result of a gene called ABCA4 and is usually a recessive trait. When both parents carry the ABCA4 mutation, there is a 25 percent chance their children will have Stargardt disease.