The Costa Concordia was only hours into a cruise of the Mediterranean on Friday 13 January 2012 when disaster struck just off Giglio island. The huge vessel - which had more than 4,000 passenger and crew onboard - then lost power, drifted and partially capsized.
The recommended dose range for metoprolol [succinate] for treating hypertension in adults is 25 to 100 mg once a day. The recommended dose range for metoprolol [succinate] for treating hypertension in children (6 years of age or older) is 0.1 mg/kg to 50 mg once a day.
The usual initial dose is 40 to 160 mcg (1 to 4 sprays 40 mcg/spray or 1 to 2 sprays 80 mcg/spray) inhaled orally twice daily. The usual maximum dose is 320 mcg (8 sprays 40 mcg/spray or 4 sprays 80 mcg/spray) inhaled orally twice daily, although higher-dose therapy has occasionally been used.