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Acute mitral valve regurgitation occurs when the mitral valve or one of its supporting structures ruptures suddenly, creating an immediate overload of blood volume and pressure in the left side of the heart. Your heart doesn't have time to adjust to the increased volume and pressure of blood (as it does in chronic MR).
The mitral valve is also prone to a disease referred to as mitral valve prolapse. With mitral valve prolapse, the mitral valve bulges slightly back into the left atrium when it closes, allowing a small amount of blood to leak backward. Mitral Valve Insufficiency/Regurgitation.1  Overview: Mitral valve insufficiency/regurgitation is a disease in which the mitral valve does not close completely, causing blood to flow backward instead of forward through the valve. 2  Mitral valve insufficiency/regurgitation may develop in response to a number of conditions.itral Valve Regurgitation, Stenosis, and Prolapse. The mitral valve is referred to as atrioventricular valves because it is located between the left atria and the left ventricle.