Efficacy is diminished and risk of ototoxicity increased in patients with hypoproteinemia (associated with nephrotic syndrome); ototoxicity is associated with rapid injection, severe renal impairment, use of higher than recommended doses, concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs.
www.phac-aspc.gc.ca. The Public Health Agency of Canada (French: Agence de la santÃ© publique du Canada) is an agency of the Government of Canada that is responsible for public health, emergency preparedness, and response and infectious and chronic disease control and prevention.
For the purpose of this document, a public health clinic is a clinic that is conducted by, or on behalf of, a state or local health jurisdiction and that receives Public Health Emergency Response (PHER) implementation funds to administer H1N1 influenza vaccine.