Females are usually carriers because they only have one copy of the disease allele. Affected males are related through carrier females. For a carrier female, with each pregnancy there is a one in two (50%) chance her sons will inherit the disease allele and a one in two (50%) chance her daughters will be carriers.
A complimentary close, also known as a complimentary closing, is the term prior to your signature in an email message or formal letter. This sign-off phrase shows your respect and appreciation for the person who is considering the request in your letter or email.
1 Be credible: Use formal grammar and punctuation. Type your letter if possible, using the appropriate format for a formal letter. 2  Request a response: Courteously ask for a response to your letter.  Sign and date your letter: Date your letter and put your name and address on both the letter and the envelope.