The Costa Concordia was only hours into a cruise of the Mediterranean on Friday 13 January 2012 when disaster struck just off Giglio island. The huge vessel - which had more than 4,000 passenger and crew onboard - then lost power, drifted and partially capsized.
The recommended dose range for metoprolol [succinate] for treating hypertension in adults is 25 to 100 mg once a day. The recommended dose range for metoprolol [succinate] for treating hypertension in children (6 years of age or older) is 0.1 mg/kg to 50 mg once a day.
Oral dosage of sotalol should be adjusted gradually allowing 2-3 days between dosing increments in order to attain steady-state, and to allow monitoring of QT intervals. Most patients respond to a daily dose of 160 to 320 mg administered in two divided doses at approximately 12 hour intervals.