Disclosure in Annual Financial Statements. If an estimate is disclosed in an interim period and that estimate is significantly changed in the final interim period (where there is no publishing of an interim report - which is usually the case), then the change in estimate is disclosed in the annual report.
The PenFill cartridge that you are currently using can be kept at room temperature up to 42 days, as long as they are kept below 86 degrees F (30 degrees C). Throw away unrefrigerated disposable Levemir PenFill cartridges after 42 days from the cartridges first use, even if it still contains Levemir.
As a general rule, most bottles of insulin are good for 28 days once they're opened. Of course, how quickly a person goes through a vial is highly individual. Some may go through a bottle in a week or two. Others, on a lower dosage, may not use all the insulin within four weeks. But the drug's stability and potency is only guaranteed for 28 days. Opened insulin pens typically last 14 days, though some last only 10 days. If you're uncertain, check with your mother's pharmacist to find out how long her insulin should last.