February 12, 2011 - Track & Field Menâs and Womenâs Track and Field Top Yale, Fall to Princeton at HYP Meet In its final meet before the Heptagonal Championships, the Harvard track and field team turned in a pair of second-place finishes at the annual HYP...
An Okazaki fragment is a relatively short fragment of DNA (with an RNA primer at the 5' terminus) created on the lagging strand during DNA replication. It was originally discovered in 1968 by Reiji Okazaki, Tsuneko Okazaki, and their colleagues while studying replication of bacteriophage DNA in Escherichia coli.
Biologically, DNA ligases are essential for the joining of Okazaki fragments during replication, and for completing short-patch DNA synthesis occurring in DNA repair process. There are two classes of DNA ligases. The first uses NAD+ as a cofactor and only found in bacteria.