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In summary, the new oral anticoagulants represent a giant step forward in the quest to replace warfarin. In addition to their enhanced convenience, the new agents are not only safer than warfarin because of the reduced risk of intracranial bleeding, but they also have the potential to be more effective.
Pharmacology of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) Versus Warfarin. Warfarin is relatively inexpensive and readily available, is partially reversible, and has well-understood interactions with other drugs. Warfarin is broadly indicated, and is suitable for patients with mechanical valves.