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A: Cymbalta (duloxetine) is an antidepressant called a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by altering the chemicals in your brain. Drowsiness and fatigue are two of the most common side effects of Cymbalta. If the Cymbalta is to be taken once daily, it may help to take the dose at bedtime.
Brintellix (vortioxetine) is an antidepressant used to treat major depressive disorder (MDD). Common side effects of Brintellix include nausea, constipation, vomiting, and sexual dysfunction.Antidepressants can raise the risk of suicidal thoughts among some users, especially among children, adolescents, and adults aged 18 to 24.he most commonly observed adverse reactions in MDD patients treated with BRINTELLIX in 6 to 8 week placebo-controlled studies (incidence â¥ 5% and at least twice the rate of placebo) were nausea, constipation and vomiting.