Females are usually carriers because they only have one copy of the disease allele. Affected males are related through carrier females. For a carrier female, with each pregnancy there is a one in two (50%) chance her sons will inherit the disease allele and a one in two (50%) chance her daughters will be carriers.
A complimentary close, also known as a complimentary closing, is the term prior to your signature in an email message or formal letter. This sign-off phrase shows your respect and appreciation for the person who is considering the request in your letter or email.
When writing a letter it typically starts out Dear... and then has the content, then before you sign it you might have a formal or informal (depending on who you're writing to) sign off, for example: blah blah blah letter content blah blah. Kind regards/Many thanks/Best wishes/Cheers!/etc. When writing a letter it typically starts out Dear... and then has the content, then before you sign it you might have a formal or informal (depending on who you're writing to) sign off, for example: blah blah blah letter content blah blah.