They observed that delivering the immunization via the rectum was most effective and that mice that received the vaccine had significantly lower levels of C. difficile colonization.(28) (1)Kelly, C.P., LaMont, J.T. âClostridium difficile infectionâ.
Happy holidays: Booking five weeks in advance is the optimal time for cheap flights, says the study. The answer is - domestic flights are at their cheapest 54 days before takeoff, which could save travellers up to Â£190. While the worst time to book a cheap flight is last minute - with the day before departure the most expensive.
The cheapest prices of the year are for travel in February, fare experts say, and those deals usually show up in November and early December. For peak-season travel, fares start fairly high and then come down. Airlines start more-actively managing pricing on flights about three-to-four months before departure.