Typically it is said when listening to someone talking-- it is a polite way to let them know that you are paying attention. Think of it as going 'mm' or 'ah'.
In addition stress can have direct effects on the skin (rashes, hives, atopic dermatitis, the gastrointestinal system (GERD, peptic ulcer, irritable bowel syndrome, ulcerative colitis) and can contribute to insomnia and degenerative neurological disorders like Parkinsonâs disease.
Effects of Too Much Cortisol and Stress. 1  Blood sugar imbalances such as hyperglycemia. 2  Decreased bone density. 3  Decrease in muscle tissue. 4  Higher blood pressure. 5  Lowered immunity and inflammatory responses in the body, slowed wound healing, and other health consequences.