Females are usually carriers because they only have one copy of the disease allele. Affected males are related through carrier females. For a carrier female, with each pregnancy there is a one in two (50%) chance her sons will inherit the disease allele and a one in two (50%) chance her daughters will be carriers.
A complimentary close, also known as a complimentary closing, is the term prior to your signature in an email message or formal letter. This sign-off phrase shows your respect and appreciation for the person who is considering the request in your letter or email.
The rule is that if you addressed it âDear Sirâ, then you sign off âYours faithfullyâ, and if you addressed the person by name, then you sign off âYours sincerelyâ. Never start a letter âDear Sir or Madamâ. In this day and age, there is no excuse for not knowing the name of the person to whom you are writing.