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It said that DNA was made up of four bases (adenine, thymine, guanine and cytosine) that were present in regular amounts, but that their organisation was too simple to carry hereditary information. It was Chargaff's work that overturned this.rwin Chargaff. Erwin Chargaff was working at Columbia University in New York in the 1940s when he read Oswald Avery's research about DNA being the hereditary material. From that moment in 1944 he devoted his research to working out the chemical composition of DNA.
To make recombinant DNA, scientists first extract the DNA they want to mix. The DNA can come from completely different organisms, including bacteria, plants, animals, algae or fungi.Using specialized lab techniques, scientists cut the pieces of DNA they want and paste them together to make an entirely new mix of DNA, called recombinant DNA, or rDNA (See References 1).ses for rDNA. DNA from different sources can be mixed to make disease-resistant crops, new vaccines, cures for genetic diseases, and proteins to use in the treatment of conditions such as sickle cell anemia, diabetes, certain cancers and other diseases (See References 2).