The Costa Concordia was only hours into a cruise of the Mediterranean on Friday 13 January 2012 when disaster struck just off Giglio island. The huge vessel - which had more than 4,000 passenger and crew onboard - then lost power, drifted and partially capsized.
The recommended dose range for metoprolol [succinate] for treating hypertension in adults is 25 to 100 mg once a day. The recommended dose range for metoprolol [succinate] for treating hypertension in children (6 years of age or older) is 0.1 mg/kg to 50 mg once a day.
Dose range: 100 to 450 mg/day. IV route: three doses of 5 mg Metoprolol administered at intervals of 2 minutes time. Oral route: if the patient gives no sign of complication from the IV route, a total of 15 mg, then a tablet of 50 mg in 6 hour block should start immediately after the IV dose.