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Ulcerative colitis treatment usually involves either drug therapy or surgery. Several categories of drugs may be effective in treating ulcerative colitis. The type you take will depend on the severity of your condition. The drugs that work well for some people may not work for others, so it may take time to find a medication that helps you.
There is no role of antibiotics in patients with severe colitis without signs of systemic toxicity [3,4]. Bowel rest is not recommended in patients with severe ulcerative colitis in the absence of fulminant disease (see 'Treatment of fulminant ulcerative colitis' below). Although bowel rest can help reduce stool volume, it has no established benefit on disease activity [5,6].