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A: Cymbalta (duloxetine) is an antidepressant called a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by altering the chemicals in your brain. Drowsiness and fatigue are two of the most common side effects of Cymbalta. If the Cymbalta is to be taken once daily, it may help to take the dose at bedtime.
Trintellix (vortioxetine) is an antidepressant that affects chemicals in the brain that may be unbalanced. Trintellix is used to treat major depressive disorder in adults. Trintellix may also be used for purposes not listed in this medication guide. Important information.