A history essay, sometimes referred to as a thesis essay, will describe an argument or claim about one or more historical events and will support that claim with evidence, arguments and references. The text makes it clear to the reader why the argument or claim is as such.
General symptoms of spinal metastatic disease include pain, sometimes from vertebral compression or collapse, nerve damage, muscle weakness and possible loss of control of the bowels or bladder. Roughly 70 percent of patients experience spinal metastatic disease.
When melanoma spreads through the bloodstream, the signs and symptoms will depend upon which organ system is involved and how much the tumor has grown there. Metastatic melanoma may be initially painless and symptom-free or may demonstrate ongoing problems according to the site. With lymphatic spread, swollen lymph glands or a string of nodules in the skin may be the presentation.