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Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous retinal detachment. number of cytokines such as tumor necrosis factor alpha (TNFÎ±), transforming growth factor beta 2 (TGFÎ² 2), platelet derived growth factor (PDGF) and interleukins have been shown to play a role in PVR progression.
They are related to, and may evolve into, myelodysplastic syndrome and acute myeloid leukemia, although the myeloproliferative diseases on the whole have a much better prognosis than these conditions. The concept of myeloproliferative disease was first proposed in 1951 by the hematologist William Dameshek.In the most recent World Health Organization classification of Hematologic malignancies, this group of diseases was renamed from myeloproliferative diseases to myeloproliferative neoplasms.This reflects the underlying clonal genetic changes that are a salient feature of this group of disease.he concept of myeloproliferative disease was first proposed in 1951 by the hematologist William Dameshek. In the most recent World Health Organization classification of Hematologic malignancies, this group of diseases was renamed from myeloproliferative diseases to myeloproliferative neoplasms.