Comment. If we are to believe this study, then there is indeed a dose-dependent correlation between alcohol abuse and paradoxical excitement response in patients sedated with propofol. The authors (and other before them) suggest this has to to with genetic variations of the GABA-receptors.
Medical Attention for a Painkiller Overdose. A known or suspected painkiller overdose is a medical emergency that requires immediate assistance. Contact your local emergency number or 9-1-1 to get help. Tell the paramedics how much of the drug was ingested and the time in which it was ingested.
An EKG can help physicians diagnose a real-time emergency, such as a heart attack in progress, but it can also help detect patterns that emerge over time. For example, if you have high blood pressure, the EKG may show that your heart has become enlarged due to the extra work of pumping blood under higher pressure.