A digoxin test may be ordered when it is suspected that levels are too low in someone who is taking the medication and has symptoms of heart failure such as: 1  Fatigue. 2  Shortness of breath. 3  Swelling in the hands and feet (edema).
lupus is a systemic autoimmune disease that has some genetic factors it is also tied to environmental risk which may determine whether people actually ever manifest the illnessthese environmental factors may also play a role in the degree to which lupus may affect a person s life and mortalityupus can manifest in different parts of the body but may include joint pain swollen legs and feet may be symptoms of lupus nephritis a form of renal parenchymal disease people can have a genetic predisposition for lupus
Genetic risk factors. About 5% to 10% of breast cancer cases are thought to be hereditary, meaning that they result directly from gene defects (called mutations) inherited from a parent. BRCA1 and BRCA2: The most common cause of hereditary breast cancer is an inherited mutation in the BRCA1 and BRCA2 genes. People with this syndrome have an increased risk of breast cancer, as well as several other cancers such as leukemia, brain tumors, and sarcomas (cancers of bones or connective tissue). 2  This is a rare cause of breast cancer. 3  CHEK2: The Li-Fraumeni syndrome can also be caused by inherited mutations in the CHEK2 gene.