Abstract. 1  Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility. In most organisms, and sometimes in both sexes, germline stem cells (GSCs) often reside in a defined anatomical niche. Factors within the niche regulate a balance between GSC self-renewal and differentiation. Asymmetric division of the germline stem cell to form daughter cells with alternative fates is common.
Heartgard Plus is a real-beef chewable tablet for dogs that provides protection against heartworms, and treats and controls roundworms and hookworms. Heartgard Plus is given monthly and requires a prescription from your veterinarian.
All dogs should start on regular heartworm prevention medicine when they are puppies. Most heartworm prevention medicines are safe for puppies as young as 6-8 weeks old.f you give your dog his heartworm âpreventionâ on April 1, and he gets bitten by a mosquito on April 2, he can get infected with baby heartworms. If you give the next dose of prevention on May 1, that medicine will kill the baby heartworms.