Those originally employed were based either on the fusion of the PCE to a tumour specific antibody (Antibody-Directed Prodrug Therapy, ADEPT) or on the delivery of the gene encoding the PCE using viral or non-viral vectors (Gene-Directed Enzyme Prodrug Therapy, GDEPT).
Urea is widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry. Friedrich WÃ¶hler's discovery in 1828 that urea can be produced from inorganic starting materials was an important conceptual milestone in chemistry.
Fresh carrots can be enjoyed as they are, or can be used raw in vegetable as well as fruit salads. Its slices easily blend with other common root vegetables like radish, beets, kohlrabi, turnips or with greens/ tomato in mixed salads.