Abstract. 1  Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility. In most organisms, and sometimes in both sexes, germline stem cells (GSCs) often reside in a defined anatomical niche. Factors within the niche regulate a balance between GSC self-renewal and differentiation. Asymmetric division of the germline stem cell to form daughter cells with alternative fates is common.
RSPCA Heartworm Tablet is a monthly heartworm preventive for dogs. The oral treatment prevents heartworm disease in dogs by eliminating the tissue stage of heartworm that infects the dog one month before by mosquitoes. Monthly treatment all year round protects dog from deadly heartworm infection. RSPCA heartworm tablet is easy to dose and highly economical. With no possible side effects, it is approved for adult dogs. RSPCA Heartworm tablets is safe for puppies above 6 weeks old.
1 Dogs and cats should be on monthly heartworm medicine all of their life starting at about 12 weeks of age. 2  We recommend that dogs be started on Ivermectin Heartworm Preventative when they test positive for Heartworms as the Ivermectin will to some degree weaken the existing adult Heartworms. Your dogâs adult heartworms should now be all killed with the completion of Heartworm Treatment Part 1. 2  Heartworm Treatment Part 2 will now kill the baby heartworms called Microfilaria, which live and circulate in the bloodstream.