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As the English, French, and Spanish explorers came to North America, they brought tremendous changes to American Indian tribes. Europeans carried a hidden enemy to the Indians: new diseases.Native peoples of America had no immunity to the diseases that European explorers and colonists brought with them.s the English, French, and Spanish explorers came to North America, they brought tremendous changes to American Indian tribes. Europeans carried a hidden enemy to the Indians: new diseases.
After that time period, several large waves of migration took place, including many groups of people from Asia and South America. Generally, the Native Americans lived in peace and prosper until around the 15th century when Europeans first arrived on the shores of North America. At that time, horses were brought over, which began to spread disease among the natives.