The Equal Rights Amendment is not yet in the U.S. Constitution. The ERA, affirming the equal application of the Constitution to all persons regardless of their sex, was written in 1923 by Alice Paul, suffragist leader and founder of the National Woman's Party.
1, muscarinic receptors are composed of seven transmembrane helical domains connected by three extracellular and three intracellular loops. Initially, on the basis of pharmacological selective affinity to the muscarinic agonist pirenzepine, two subtypes of muscarinic receptors, M 1 R and M 2 R, were described (61).
The appeal of such an approach is that it. may be possible to define a muscarinic receptor SUbtype in terms of its amino. acid sequencc, pharmacological profile (in binding and functional studies), and its ability to activate selectively one effector mechanism.