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Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous retinal detachment. number of cytokines such as tumor necrosis factor alpha (TNFÎ±), transforming growth factor beta 2 (TGFÎ² 2), platelet derived growth factor (PDGF) and interleukins have been shown to play a role in PVR progression.
As we age, the gel-like substance that fills the eye (the vitreous) shrinks and separates from the retina. This is called a vitreous detachment, or posterior vitreous detachment (PVD) .In most cases, a vitreous detachment is not sight-threatening and does not require treatment.s we age, the gel-like substance that fills the eye (the vitreous) shrinks and separates from the retina. This is called a vitreous detachment, or posterior vitreous detachment (PVD) .