Comment. If we are to believe this study, then there is indeed a dose-dependent correlation between alcohol abuse and paradoxical excitement response in patients sedated with propofol. The authors (and other before them) suggest this has to to with genetic variations of the GABA-receptors.
Medical Attention for a Painkiller Overdose. A known or suspected painkiller overdose is a medical emergency that requires immediate assistance. Contact your local emergency number or 9-1-1 to get help. Tell the paramedics how much of the drug was ingested and the time in which it was ingested.
You should seek immediate medical attention if you have: 1  A sudden headache or if your headaches change in pattern, intensity or symptoms. 2  An abrupt, head pain like a thunderclap. 3  Headache that is accompanied by fever, stiff neck, rash, seizures, mental confusion, double vision, weakness, numbness or trouble speaking.