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An example of genetic variation is like sickle cell anemia. Sickle cell anemia is a mutation but is adaptive where malaria exists, like in Africa, it helps fight off the disease. But in a place like America it is not adaptive so its less common.
For example if you have in the populations the two following variants at the same locus: AGCCGT and AGCTGT, then you have a SNP at the position of the C and T. This type of variation is very common. We estimate that there are about 10 millions SNPs in the human genome. We often use these SNPs as genetic markers.