The Equal Rights Amendment is not yet in the U.S. Constitution. The ERA, affirming the equal application of the Constitution to all persons regardless of their sex, was written in 1923 by Alice Paul, suffragist leader and founder of the National Woman's Party.
1, muscarinic receptors are composed of seven transmembrane helical domains connected by three extracellular and three intracellular loops. Initially, on the basis of pharmacological selective affinity to the muscarinic agonist pirenzepine, two subtypes of muscarinic receptors, M 1 R and M 2 R, were described (61).
Purinergic receptors are one of the evolutionary oldest receptors [9] . The receptor family can be found in almost every mammalian tissue and was initially described in gut smooth muscle cells in the 1970s [7] and [8] .In 2014 the first purinergic receptor, namely DORN1, was discovered in plants [6] .Purinergic receptors are divided into P1 receptors which are preferentially activated by adenosine and P2 receptors which are activated by a variety of nucleotides.he role of P1 receptors in MSC proliferation is not well studied. There is some evidence suggesting that adenosine and the adenosine A2A receptor are important mediators in stimulating proliferation and differentiation of mouse BM-MSCs [96] .