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Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous retinal detachment. number of cytokines such as tumor necrosis factor alpha (TNFÎ±), transforming growth factor beta 2 (TGFÎ² 2), platelet derived growth factor (PDGF) and interleukins have been shown to play a role in PVR progression.
Proliferative Retinal Detachment - Background. 1  Proliferative vitreoretinopathy (PVR) is the most common cause of failure in retinal detachment surgery. 2  Also see the clinical guideline summary from the American Academy of Ophthalmology, Posterior vitreous detachment, retinal breaks, and lattice degeneration.