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Fluconazole: Peak plasma concentrations in fasted normal volunteers occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours (range: 20 to 50 hours) after oral administration. If you wait 5 half-lives it will all be gone.
If you are allergic to fluconazole or any of its inactive ingredients, you should not take fluconazole. If you are taking medications that can change the electrical activity in the heart you should not take this drug. Also, if you have severe kidney problems (kidneys with a creatinine clearance, CrCl, or urine output 50 ml/ minute or less), your body may not be able to eliminate fluconazole as quickly as it should.