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Many side effects of iron supplements, including nausea, leg cramps, diarrhea and constipation, tend to go away as the patient's body adapts to the supplement, explains Mayo Clinic. Patients who are extremely bothered by these side effects can contact their doctors for advice to reduce the symptoms but should not be alarmed.
Some supplements can affect how your body absorbs iron from a supplement. Calcium and zinc can both interfere with iron absorption, so if you take a calcium supplement, or a multivitamin with calcium and zinc, try to take it well before or after your iron pill.hen taking an iron supplement, try it first on an empty stomach. Food in general can reduce the absorption of iron by about 40 to 50 percent, so ideally, aim to take your iron supplement about two hours before or after youâve eaten.