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But inherited gene mutations are not thought to cause very many bile duct cancers. Gene mutations related to bile duct cancers are usually acquired during life rather than being inherited. For example, acquired changes in the TP53 tumor suppressor gene are found in most bile duct cancers.Other genes that may play a role in bile duct cancers include KRAS, HER2, and MET. Some of the gene changes that lead to bile duct cancer might be caused by inflammation.But sometimes what causes these changes is not known. Many gene changes might just be random events that sometimes happen inside a cell, without having an outside cause.ut inherited gene mutations are not thought to cause very many bile duct cancers. Gene mutations related to bile duct cancers are usually acquired during life rather than being inherited. For example, acquired changes in the TP53 tumor suppressor gene are found in most bile duct cancers.
Biliary Disorders and Bile Duct Cancer. The biliary duct system is responsible for storing and transporting bile, a yellowish digestive fluid produced in the liver. The bile ducts are the tubes from which bile flows out from the liver. Bile ducts come together like the branches of a tree.The largest duct is called the common bile duct. Before bile is transported to the small intestine to aid in the digestive process, it is collected and concentrated in a storage container called the gallbladder.iliary Stricture. A biliary stricture is a narrowing of the common bile duct. When this happens, bile can back up into the liver, causing abdominal pain, nausea, itching, fever, chills, and jaundice. Strictures can be caused during surgery on nearby tissues, such as the gallbladder.