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Fluconazole: Peak plasma concentrations in fasted normal volunteers occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours (range: 20 to 50 hours) after oral administration. If you wait 5 half-lives it will all be gone.
It takes 5.5 half lives for a drug to be out of your system. The elimination half-life of metronidazole is 7-8 hours, therefore it would take 44 hours (5.5 x 8 hours) or approximately 2 days before metronidazole is out of your system. So alcohol should be avoided during and for 48 hours after stopping therapy. Source(s): http://www.medsafe.govt.nz/profs/Datashe...