Comment. If we are to believe this study, then there is indeed a dose-dependent correlation between alcohol abuse and paradoxical excitement response in patients sedated with propofol. The authors (and other before them) suggest this has to to with genetic variations of the GABA-receptors.
Medical Attention for a Painkiller Overdose. A known or suspected painkiller overdose is a medical emergency that requires immediate assistance. Contact your local emergency number or 9-1-1 to get help. Tell the paramedics how much of the drug was ingested and the time in which it was ingested.
How An Overdose Causes Brain Damage. Opiates and opioids (heroin, morphine, OxyContin, Fentanyl) are depressants, meaning the drugs slow down your breathing and heart rate. As such, the most significant risk of an overdose is the lack of oxygen. An opiate overdose typically leads to unconsciousness and a very depressed central nervous system, which is responsible for your respiratory drive while sleeping.