If you find a link not working or an error of any sort, please e-mail the FAQ author. The Tornado FAQ is not intended to be a comprehensive guide to tornadoes. Instead, it is a quick-reference summary of tornado knowledge, which will link you to more detailed information if you desire.
But inherited gene mutations are not thought to cause very many bile duct cancers. Gene mutations related to bile duct cancers are usually acquired during life rather than being inherited. For example, acquired changes in the TP53 tumor suppressor gene are found in most bile duct cancers.Other genes that may play a role in bile duct cancers include KRAS, HER2, and MET. Some of the gene changes that lead to bile duct cancer might be caused by inflammation.But sometimes what causes these changes is not known. Many gene changes might just be random events that sometimes happen inside a cell, without having an outside cause.ut inherited gene mutations are not thought to cause very many bile duct cancers. Gene mutations related to bile duct cancers are usually acquired during life rather than being inherited. For example, acquired changes in the TP53 tumor suppressor gene are found in most bile duct cancers.
Genetic risk factors. About 5% to 10% of breast cancer cases are thought to be hereditary, meaning that they result directly from gene defects (called mutations) inherited from a parent. BRCA1 and BRCA2: The most common cause of hereditary breast cancer is an inherited mutation in the BRCA1 and BRCA2 genes. People with this syndrome have an increased risk of breast cancer, as well as several other cancers such as leukemia, brain tumors, and sarcomas (cancers of bones or connective tissue). 2  This is a rare cause of breast cancer. 3  CHEK2: The Li-Fraumeni syndrome can also be caused by inherited mutations in the CHEK2 gene.