Paget disease of the breast is named after the 19th century British doctor Sir James Paget, who, in 1874, noted a relationship between changes in the nipple and breast cancer. (Several other diseases are named after Sir James Paget, including Paget disease of bone and extramammary Paget disease, which includes Paget disease of the vulva and Paget disease of the penis.
The 2015 Major League Soccer season features 20 total clubs (17 based in the United States, 3 based in Canada). The regular season is held from March 6 through to October 25, whereas the MLS Cup Playoffs will be held from October 28 to early December. The defending MLS Cup champions are the LA Galaxy, while Seattle Sounders FC are the defending Supporters' Shield winners.
Major League Soccer (MLS) is a men's professional soccer league, sanctioned by U.S. Soccer, that represents the sport's highest level in both the United States and Canada. MLS constitutes one of the major professional sports leagues of the United States and Canada. The league comprises 22 teamsâ19 in the U.S. and 3 in Canada. The MLS regular season runs from March to October, with each team playing 34 games; the team with the best record is awarded the Supporters' Shield.