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Fluconazole: Peak plasma concentrations in fasted normal volunteers occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours (range: 20 to 50 hours) after oral administration. If you wait 5 half-lives it will all be gone.
It will stay in your body for over a week. If you have taken only one dosage, then diflucan will stay in your system for about 30 hours to three to four days. It is difficult to state the exact time period, but that is how long it might take infection to clear up with a single dose if the infection is mild.