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But inherited gene mutations are not thought to cause very many bile duct cancers. Gene mutations related to bile duct cancers are usually acquired during life rather than being inherited. For example, acquired changes in the TP53 tumor suppressor gene are found in most bile duct cancers.Other genes that may play a role in bile duct cancers include KRAS, HER2, and MET. Some of the gene changes that lead to bile duct cancer might be caused by inflammation.But sometimes what causes these changes is not known. Many gene changes might just be random events that sometimes happen inside a cell, without having an outside cause.ut inherited gene mutations are not thought to cause very many bile duct cancers. Gene mutations related to bile duct cancers are usually acquired during life rather than being inherited. For example, acquired changes in the TP53 tumor suppressor gene are found in most bile duct cancers.
Bile is made in the liver. It contains a mix of products such as bilirubin, cholesterol, and bile acids and salts. Bile ducts are drainage âpipesâ that carry bile from the liver to the gallbladder and from the gallbladder to the small intestine. A variety of diseases can affect your bile ducts.All block the bile ducts in some way, which is why the various diseases cause similar symptoms.Gallstones are the most common cause of blocked bile ducts. Stones typically form inside the gallbladder and can block the common bile duct, the drainpipe at the base of the liver. variety of diseases can affect your bile ducts. All block the bile ducts in some way, which is why the various diseases cause similar symptoms. Gallstones are the most common cause of blocked bile ducts.