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Look up foramen in Wiktionary, the free dictionary. In anatomy, a foramen (/fÉËreÉªmÉn/; pl. foramina, /fÉËrÃ¦máµ»nÉ/) is any opening. Foramina inside the body of humans and other animals typically allow muscles, nerves, arteries, veins, or other structures to connect one part of the body with another.
A patent foramen ovale (PFO) is a defect in the septum (wall) between the two upper (atrial) chambers of the heart. Specifically, the defect is an incomplete closure of the at â¦ rial septum that results in the creation of a flap or a valve-like opening in the atrial septal wall (see illustration).