Paget disease of the breast is named after the 19th century British doctor Sir James Paget, who, in 1874, noted a relationship between changes in the nipple and breast cancer. (Several other diseases are named after Sir James Paget, including Paget disease of bone and extramammary Paget disease, which includes Paget disease of the vulva and Paget disease of the penis.
The 2015 Major League Soccer season features 20 total clubs (17 based in the United States, 3 based in Canada). The regular season is held from March 6 through to October 25, whereas the MLS Cup Playoffs will be held from October 28 to early December. The defending MLS Cup champions are the LA Galaxy, while Seattle Sounders FC are the defending Supporters' Shield winners.
Major League Soccer is the most recent of a series of men's premier professional national soccer leagues established in the United States and Canada. The predecessor of MLS was the North American Soccer League (NASL), which played from 1968 until 1984.