Abstract. 1  Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility. In most organisms, and sometimes in both sexes, germline stem cells (GSCs) often reside in a defined anatomical niche. Factors within the niche regulate a balance between GSC self-renewal and differentiation. Asymmetric division of the germline stem cell to form daughter cells with alternative fates is common.
Heartgard Plus is a real-beef chewable tablet for dogs that provides protection against heartworms, and treats and controls roundworms and hookworms. Heartgard Plus is given monthly and requires a prescription from your veterinarian.
The larvae enter a new animal's body when it is bitten by an infected mosquito. Larvae mature and migrate to the pet's heart. Worms in the heart mate and produce microfilariae (6-7 months after infection in dogs, 8 months in cats). An important part of a complete heartworm prevention program is testing. All dogs should be tested for heartworm infection before starting a preventive program.