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Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous retinal detachment. number of cytokines such as tumor necrosis factor alpha (TNFÎ±), transforming growth factor beta 2 (TGFÎ² 2), platelet derived growth factor (PDGF) and interleukins have been shown to play a role in PVR progression.
Over the years, premacular fibrosis (PMF) has gone by many different names including cellophane maculopathy, epiretinal membrane (ERM), and macular pucker. Its nasty first cousin is proliferative vitreoretinopathy (PVR).Premacular fibrosis (PMF) is another of several diseases that affects the macula, the center of the retina, the portion of the retina that provides the detailed vision that we use for reading, driving, and detailed work.The disease has its effects on the front side of the retina.Macular degeneration affects the underside of the retina. Although the symptoms are superficially somewhat similar, PMF is definitely not macular degeneration. It has a distinct mechanism of action, prognosis, and therapy.he disease has its effects on the front side of the retina. Macular degeneration affects the underside of the retina. Although the symptoms are superficially somewhat similar, PMF is definitely not macular degeneration. It has a distinct mechanism of action, prognosis, and therapy.