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Oral cancer symptoms. Some of the most common oral cancer symptoms and signs include: 1  Persistent mouth sore: A sore in the mouth that does not heal is the most common symptom of oral cancer. 2  Pain: Persistent mouth pain is another common oral cancer sign.  A lump or thickening in the cheek.
In a few cases, a long-lasting mouth ulcer can be a sign of mouth cancer. Ulcers caused by mouth cancer usually appear on or under the tongue, although you can get them in other areas of the mouth. It's important to detect mouth cancer as early as possible.