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Fluconazole: Peak plasma concentrations in fasted normal volunteers occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours (range: 20 to 50 hours) after oral administration. If you wait 5 half-lives it will all be gone.
How long does Suboxone stay in your system? Suboxone lasts long enough that you only have to use it once a day. Based on the buprenorphine content, this medicine has a half-life of 24 to 42 hours. This means that it takes 24 to 42 hours for the level of buprenorphine to drop by 50 percent in your blood. Therefore, it may take several days, or even a week or longer, for this drug to be mostly out of your system.