Comment. If we are to believe this study, then there is indeed a dose-dependent correlation between alcohol abuse and paradoxical excitement response in patients sedated with propofol. The authors (and other before them) suggest this has to to with genetic variations of the GABA-receptors.
Medical Attention for a Painkiller Overdose. A known or suspected painkiller overdose is a medical emergency that requires immediate assistance. Contact your local emergency number or 9-1-1 to get help. Tell the paramedics how much of the drug was ingested and the time in which it was ingested.
Some doctors' offices are equipped to handle overdoses; others are not. Some doctors' offices advise their patients to go to a hospital's emergency department. In life-threatening circumstances, an ambulance should usually be summoned by calling 911.You are not expected to know when a drug overdose is serious.