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Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous retinal detachment. number of cytokines such as tumor necrosis factor alpha (TNFÎ±), transforming growth factor beta 2 (TGFÎ² 2), platelet derived growth factor (PDGF) and interleukins have been shown to play a role in PVR progression.
Proliferative Retinal Detachment - Epidemiology. 1  United States. 2  Of all retinal detachment surgery cases, 5-10% develop proliferative vitreoretinopathy. 3  International. 4  Worldwide incidence is the same as that in the United States. 5  Proliferative vitreoretinopathy has no associated mortality.