Abstract. 1  Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility. In most organisms, and sometimes in both sexes, germline stem cells (GSCs) often reside in a defined anatomical niche. Factors within the niche regulate a balance between GSC self-renewal and differentiation. Asymmetric division of the germline stem cell to form daughter cells with alternative fates is common.
Heartgard Plus is a real-beef chewable tablet for dogs that provides protection against heartworms, and treats and controls roundworms and hookworms. Heartgard Plus is given monthly and requires a prescription from your veterinarian.
Certain forms of heartworm prevention may be harmful to dogs that are heartworm positive. Giving your dog heartworm prevention is an ESSENTIAL part of being a responsible dog owner. In addition, it is safer and less expensive to prevent heartworms than to put your dog through heartworm treatment for heartworm disease. Heartworm prevention costs about $35-$250 per year depending on the size of the dog and the brand of prevention chosen.