Abstract. 1  Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility. In most organisms, and sometimes in both sexes, germline stem cells (GSCs) often reside in a defined anatomical niche. Factors within the niche regulate a balance between GSC self-renewal and differentiation. Asymmetric division of the germline stem cell to form daughter cells with alternative fates is common.
Heartgard Plus is a real-beef chewable tablet for dogs that provides protection against heartworms, and treats and controls roundworms and hookworms. Heartgard Plus is given monthly and requires a prescription from your veterinarian.
How do I prevent my dog from getting heartworms? Heartworms have been found in dogs in all 50 states so all dogs are at risk, even those animals that primarily live indoors. Fortunately, with medication, heartworm infection is almost always preventable. Ask your veterinarian about heartworm prevention. Preventive treatment should begin at 6 or 8 weeks of age in puppies and after tests have been conducted in older dogs to determine if your dog has already been infected. An annual blood test should be run to confirm the dog continues to be negative for heartworms.