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Smallpox was officially declared eradicated in 1980 and is the first disease to have been fought on a global scale.This extraordinary achievement was accomplished through the collaboration of countries around the world. At the end of the 1960s, smallpox was still endemic in Africa and Asia.mallpox was officially declared eradicated in 1980 and is the first disease to have been fought on a global scale.
1 Smallpox: Smallpox is a serious, contagious, and sometimes fatal infectious disease caused by the variola virus. 2  Historically, smallpox had a mortality rate of as much as 30 percent. 3  In the Americas, it killed as much as 90 percent of the indigenous population after contact with Europeans introduced the disease. Smallpox: Smallpox is a serious, contagious, and sometimes fatal infectious disease caused by the variola virus. 2  Historically, smallpox had a mortality rate of as much as 30 percent. 3  In the Americas, it killed as much as 90 percent of the indigenous population after contact with Europeans introduced the disease.