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Oral cancer symptoms. Some of the most common oral cancer symptoms and signs include: 1  Persistent mouth sore: A sore in the mouth that does not heal is the most common symptom of oral cancer. 2  Pain: Persistent mouth pain is another common oral cancer sign.  A lump or thickening in the cheek.
Tongue cancer usually develops in the squamous cells, the thin, flat cells that cover the surface of the tongue. Common tongue cancer symptoms. Symptoms of tongue cancer are very similar to symptoms of other types of oral cancer. It can often be mistaken for a cold that wonât go away, or a persistent sore in the mouth. Other tongue cancer symptoms and signs may include: Persistent tongue and/or jaw pain.