An advance is usually 1/3 of the first print run total royalties. For example, if a book has a print run of 5000 copies and will be sold at $14.95 and the author is to receive 10% royalties, the total sum payable to the author if all copies are sold is $7475 (10% x $14.95 x 5000).
Mayo Clinic researchers have found that a sometimes deadly stomach bug, Clostridium difficile, is on the rise in outpatient settings. Clostridium difficile is a serious bacteria that can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon.
Bubonic plague is fatal (though there is now a cure) and leads to an infection of the lymph nodes, which become swollen (bubo is Latin for bump). Here's what actually happens. The bacteria grow inside the flea, causing conditions which block the insect's stomach and induce extreme hunger. The flea starts to feed on a host, and in this way the disease spreads. Boccaccio, Plutarch and Chaucer all mention the Black Death in their literary works. The disease made short life spans even shorter.