Downstream of dams, marked changes in fish populations occur as a consequence of blockage of migration routes, disconnection of the river and floodplain and changes in flow regime, physiochemical conditions (e.g. temperature, turbidity and dissolved oxygen), primary production and channel morphology.
A final consideration is allergic reactions to the glaucoma drugs. âWith both Combigan and Simbrinza, the allergy rates are unknown. Brimonidine is a component of both drugs; when it was first introduced, it was associated with a 20% allergy rate.he availability of combination anti-glaucoma therapies is a boon for patients and physicians when considering that about 40% of patients with glaucoma require two or more drugs to control elevated IOP levels.
A global Phase 3 programme is now underway evaluating the safety and efficacy of the concomitant use of solifenacin (known commercially as VESICARE(TM)) and mirabegron (known commercially as BETMIGA(TM)), for the treatment of overactive bladder.