Comment. If we are to believe this study, then there is indeed a dose-dependent correlation between alcohol abuse and paradoxical excitement response in patients sedated with propofol. The authors (and other before them) suggest this has to to with genetic variations of the GABA-receptors.
Medical Attention for a Painkiller Overdose. A known or suspected painkiller overdose is a medical emergency that requires immediate assistance. Contact your local emergency number or 9-1-1 to get help. Tell the paramedics how much of the drug was ingested and the time in which it was ingested.
A painkiller overdose can occur when a person takes more than the amount of medication prescribed by his or her doctor, or more than the recommended dosage of an over-the-counter pain reliever. An individual who is in pain and has developed a tolerance for the medication being taken may be tempted to take a higher amount than directed or more frequently than instructed.