Common causes of skin changes include: 1  Skin puckering or dimpling. 2  Skin puckering or dimpling can be caused by scarring from a previous operation or infection, but in the majority of cases, no specific reason can be found. 3  Most often it is not a sign of underlying cancer, but should be evaluated with exam and imaging.
By Mayo Clinic Staff. Night leg cramps, also called nocturnal leg cramps, are painful, involuntary contractions or spasms of muscles in your legs, usually occurring when you're in bed. Night leg cramps usually involve your calf muscles, although muscles in your feet or thighs might cramp as well.
And even if you aren't taking one of these drugs, it's still wise to consult with your doctor if you often cramp up at night. In most cases, leg cramps are harmless. But they can signal an underlying medical problem, especially if you also have muscle weakness, swelling, or numbness or pain that just won't go away.nd even if you aren't taking one of these drugs, it's still wise to consult with your doctor if you often cramp up at night. In most cases, leg cramps are harmless. But they can signal an underlying medical problem, especially if you also have muscle weakness, swelling, or numbness or pain that just won't go away.