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Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous retinal detachment. number of cytokines such as tumor necrosis factor alpha (TNFÎ±), transforming growth factor beta 2 (TGFÎ² 2), platelet derived growth factor (PDGF) and interleukins have been shown to play a role in PVR progression.
Diabetic retinopathy may progress through four stages: 1  Mild nonproliferative retinopathy. Small areas of balloon-like swelling in the retinaâs tiny blood vessels, called microaneurysms, occur at this earliest stage of the disease. 2  Moderate nonproliferative retinopathy.