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Oral cancer symptoms. Some of the most common oral cancer symptoms and signs include: 1  Persistent mouth sore: A sore in the mouth that does not heal is the most common symptom of oral cancer. 2  Pain: Persistent mouth pain is another common oral cancer sign.  A lump or thickening in the cheek.
Mouth Cancer Symptoms: Early Warning Signs. It's a sad fact that every year approximately 34,000 Americans are diagnosed with oral cancer. It's even sadder that oral cancer results in approximately 8,000 deaths annually, according to the Oral Cancer Foundation.