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sliding filament theory A proposed mechanism of muscle contraction in which the actin and myosin filaments of striated muscle slide over each other to shorten the length of the muscle fibres (see sarcomere). Myosin-binding sites on the actin filaments are exposed when calcium ions bind to troponin molecules in these filaments.
The molecular changes that result in muscle contraction have been conserved across evolution in the majority of animals. By studying sarcomeres, the basic unit controlling changes in muscle length, scientists proposed the sliding filament theory to explain the molecular mechanisms behind muscle contraction.