Comment. If we are to believe this study, then there is indeed a dose-dependent correlation between alcohol abuse and paradoxical excitement response in patients sedated with propofol. The authors (and other before them) suggest this has to to with genetic variations of the GABA-receptors.
Medical Attention for a Painkiller Overdose. A known or suspected painkiller overdose is a medical emergency that requires immediate assistance. Contact your local emergency number or 9-1-1 to get help. Tell the paramedics how much of the drug was ingested and the time in which it was ingested.
IMPORTANT SAFETY INFORMATION. 1  Get emergency help right away if you take too much EMBEDA (overdose). When you first start taking EMBEDA, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur.