Abstract. 1  Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility. In most organisms, and sometimes in both sexes, germline stem cells (GSCs) often reside in a defined anatomical niche. Factors within the niche regulate a balance between GSC self-renewal and differentiation. Asymmetric division of the germline stem cell to form daughter cells with alternative fates is common.
Heartgard Plus is a real-beef chewable tablet for dogs that provides protection against heartworms, and treats and controls roundworms and hookworms. Heartgard Plus is given monthly and requires a prescription from your veterinarian.
4. Despite what your veterinarian may have told you, there is NO prevention for heartworm infection; there is only heartworm treatment. ALL heartworm medicines work the same way -- they kill heartworm microfilaria present in the body of the dog.here is no preventive medicine for Heartworm. Despite what your veterinarian may have told you, there is NO prevention for heartworm infection; there is only heartworm treatment. ALL heartworm medicines work the same way -- they kill heartworm microfilaria present in the body of the dog.