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Oral cancer symptoms. Some of the most common oral cancer symptoms and signs include: 1  Persistent mouth sore: A sore in the mouth that does not heal is the most common symptom of oral cancer. 2  Pain: Persistent mouth pain is another common oral cancer sign.  A lump or thickening in the cheek.
Diagnosing mouth cancer. If you have symptoms of mouth cancer, your GP or dentist will carry out a physical examination and ask about your symptoms. If mouth cancer is suspected, you'll be referred to hospital for further tests or to speak to a specialist oral and maxillofacial surgeon.