Abstract. 1  Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility. In most organisms, and sometimes in both sexes, germline stem cells (GSCs) often reside in a defined anatomical niche. Factors within the niche regulate a balance between GSC self-renewal and differentiation. Asymmetric division of the germline stem cell to form daughter cells with alternative fates is common.
Heartgard Plus is a real-beef chewable tablet for dogs that provides protection against heartworms, and treats and controls roundworms and hookworms. Heartgard Plus is given monthly and requires a prescription from your veterinarian.
1 Heartworms are worms that live in the right side of the heart of dogs and cats. 2  Heartworms are carried by mosquitos and the mosquitos transfer the baby heartworms from one dog to another dog or cat when it bites them. 3  The worms can be 6-18 inches long and resemble a thin spaghetti noodle. Your dogâs adult heartworms should now be all killed with the completion of Heartworm Treatment Part 1. 2  Heartworm Treatment Part 2 will now kill the baby heartworms called Microfilaria, which live and circulate in the bloodstream.