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This is the recommended timeline for puppy vaccinations. Puppies normally get their first shots around 8 weeks old, but they can be given earlier if needed (ie with stray, abandoned pups or those who were formula fed). Three sets of combination vaccinations (a shot that protects against more than one disease) given at 3 week intervals. 8 weeks - first round.
1 Your puppyâs first vaccination will come when she is three to four months old; annual boosters are required. 2  Canine distemper was a major killer of canines in the past; now it is common only in rescue shelters and pet stores. 3  But itâs still widely seen in the wild, so it is always a risk.