Abstract. 1  Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility. In most organisms, and sometimes in both sexes, germline stem cells (GSCs) often reside in a defined anatomical niche. Factors within the niche regulate a balance between GSC self-renewal and differentiation. Asymmetric division of the germline stem cell to form daughter cells with alternative fates is common.
Heartgard Plus is a real-beef chewable tablet for dogs that provides protection against heartworms, and treats and controls roundworms and hookworms. Heartgard Plus is given monthly and requires a prescription from your veterinarian.
1 Dogs and cats should be on monthly heartworm medicine all of their life starting at about 12 weeks of age. 2  We recommend that dogs be started on Ivermectin Heartworm Preventative when they test positive for Heartworms as the Ivermectin will to some degree weaken the existing adult Heartworms. Your dogâs adult heartworms should now be all killed with the completion of Heartworm Treatment Part 1. 2  Heartworm Treatment Part 2 will now kill the baby heartworms called Microfilaria, which live and circulate in the bloodstream.