Comment. If we are to believe this study, then there is indeed a dose-dependent correlation between alcohol abuse and paradoxical excitement response in patients sedated with propofol. The authors (and other before them) suggest this has to to with genetic variations of the GABA-receptors.
Medical Attention for a Painkiller Overdose. A known or suspected painkiller overdose is a medical emergency that requires immediate assistance. Contact your local emergency number or 9-1-1 to get help. Tell the paramedics how much of the drug was ingested and the time in which it was ingested.
This can cause the patient to die. That is why it is important to recognize the signs of a heart attack and seek prompt medical attention at the nearest hospital with 24-hour emergency cardiac care. About one-fifth of all heart attacks are silent, that is, the victim does not know one has occurred.