Comment. If we are to believe this study, then there is indeed a dose-dependent correlation between alcohol abuse and paradoxical excitement response in patients sedated with propofol. The authors (and other before them) suggest this has to to with genetic variations of the GABA-receptors.
Medical Attention for a Painkiller Overdose. A known or suspected painkiller overdose is a medical emergency that requires immediate assistance. Contact your local emergency number or 9-1-1 to get help. Tell the paramedics how much of the drug was ingested and the time in which it was ingested.
If someone has attempted suicide: 1  Don't leave the person alone. 2  Call 911 or your local emergency number right away. 3  Or, if you think you can do so safely, take the person to the nearest hospital emergency room yourself. 4  Try to find out if he or she is under the influence of alcohol or drugs or may have taken an overdose. Call 911 or your local emergency number right away. 2  Or, if you think you can do so safely, take the person to the nearest hospital emergency room yourself. 3  Try to find out if he or she is under the influence of alcohol or drugs or may have taken an overdose. 4  Tell a family member or friend right away what's going on.