Car tuning - Areas of modification. 1  The essence of modification of a tuner car is an attempt to extract the greatest possible performanceâor the appearance of high performanceâfrom the base motor vehicle through the addition, alteration or outright replacement of parts.
The distribution of weakness is typically proximal, with variable involvement of [â¦] Nemaline myopathy (NM) is a disorder characterized by muscle weakness, depressed/absent deep tendon reflexes and the presence of rod-shaped structures in muscle cells.
Many of the inherited myopathies are caused by mutations that interfere with ion channels, causing either too much or too little current from flowing through the muscle cells. These disorders (myotonia congenita, paramyotonia congenita, periodic paralysis and central core disease) are sometimes called channelopathies. Central core disease seems to damage, and thus weaken, muscles by causing an excess release of calcium from internal storage compartments. A fifth myopathy, nemaline myopathy, is caused by mutations that affect filament proteins.