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But inherited gene mutations are not thought to cause very many bile duct cancers. Gene mutations related to bile duct cancers are usually acquired during life rather than being inherited. For example, acquired changes in the TP53 tumor suppressor gene are found in most bile duct cancers.Other genes that may play a role in bile duct cancers include KRAS, HER2, and MET. Some of the gene changes that lead to bile duct cancer might be caused by inflammation.But sometimes what causes these changes is not known. Many gene changes might just be random events that sometimes happen inside a cell, without having an outside cause.ut inherited gene mutations are not thought to cause very many bile duct cancers. Gene mutations related to bile duct cancers are usually acquired during life rather than being inherited. For example, acquired changes in the TP53 tumor suppressor gene are found in most bile duct cancers.
Doctors divide bile duct cancer into different types based on where the cancer occurs in the bile ducts: 1  Intrahepatic cholangiocarcinoma occurs in the parts of the bile ducts within the liver and is sometimes classified as a type of liver cancer.  Hilar cholangiocarcinoma occurs in the bile ducts just outside of the liver.