Abstract. 1  Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility. In most organisms, and sometimes in both sexes, germline stem cells (GSCs) often reside in a defined anatomical niche. Factors within the niche regulate a balance between GSC self-renewal and differentiation. Asymmetric division of the germline stem cell to form daughter cells with alternative fates is common.
RSPCA Heartworm Tablet is a monthly heartworm preventive for dogs. The oral treatment prevents heartworm disease in dogs by eliminating the tissue stage of heartworm that infects the dog one month before by mosquitoes. Monthly treatment all year round protects dog from deadly heartworm infection. RSPCA heartworm tablet is easy to dose and highly economical. With no possible side effects, it is approved for adult dogs. RSPCA Heartworm tablets is safe for puppies above 6 weeks old.
The newer heartworm drugs are less dangerous to dogs who are infected with adult heartworms. They can even be used to kill the microfilariae produced by the adult worms in the body, and have some effect against the adult worms. Heartworm testing is still recommended before administration of these drugs.