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Many side effects of iron supplements, including nausea, leg cramps, diarrhea and constipation, tend to go away as the patient's body adapts to the supplement, explains Mayo Clinic. Patients who are extremely bothered by these side effects can contact their doctors for advice to reduce the symptoms but should not be alarmed.
Quick Answer. Iron supplements typically take effect after two months of consistent doses. Supplements should be taken for six to 12 months to rebuild the body's iron reserves following a deficiency, according to MedlinePlus. Continue Reading.