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Smallpox was officially declared eradicated in 1980 and is the first disease to have been fought on a global scale.This extraordinary achievement was accomplished through the collaboration of countries around the world. At the end of the 1960s, smallpox was still endemic in Africa and Asia.mallpox was officially declared eradicated in 1980 and is the first disease to have been fought on a global scale.
The last naturally occurring case of smallpox (Variola minor) was diagnosed on 26 October 1977. Infection with smallpox is focused in small blood vessels of the skin and in the mouth and throat before disseminating. In the skin it results in a characteristic maculopapular rash and, later, raised fluid-filled blisters.V. major produced a more serious disease and had an overall mortality rate of 30â35 percent.n the early 1950s an estimated 50 million cases of smallpox occurred in the world each year. To eradicate smallpox, each outbreak had to be stopped from spreading, by isolation of cases and vaccination of everyone who lived close by.