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Definition of CEREBRAL HEMISPHERE. : either of the two hollow convoluted lateral halves of the cerebrum â see brain illustration.
The cerebral cortex is the cerebrum 's (brain) outer layer of neural tissue in humans and other mammals.It is divided into two cortices, along the sagittal plane: the left and right cerebral hemispheres divided by the medial longitudinal fissure.n large mammals, the cerebral cortex is folded, giving a much greater surface area in the confined volume of the skull. A fold or ridge in the cortex is termed a gyrus (plural gyri) and a groove or fissure is termed a sulcus (plural sulci).