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Dose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.One of the attractions of this medication is its long 'half-life' - it stays in the system for days & weeks.ose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.
High risk patients would include those who: 1  have taken high doses of Plaquenil for years (i.e., 1000 g. for over 7 years) 2  are 60 years or older. 3  are obese.  have significant liver or kidney 1  disease. have pre-existing retinal, macular disease, or cataracts.