Definition of TISSUE PLASMINOGEN ACTIVATOR. : a clot-dissolving enzyme with an affinity for fibrin that is produced naturally in blood vessel linings and is used in a genetically engineered form to prevent damage to heart muscle following a heart attack and reduce neurological damage following ischemic stroke âabbreviation TPA.ADVERTISEMENT. a clot-dissolving enzyme with an affinity for fibrin that is produced naturally in blood vessel linings and is used in a genetically engineered form to prevent damage to heart muscle following a heart attack and reduce neurological damage following ischemic stroke âabbreviation TPA. ADVERTISEMENT.
Causation principle refers to the relation between the cause or an event and the effect or a second event. The second event is the physical result of the first.      â¦ . Torrey Garcia.
1 E. J. Tapp, âSome Aspects of Causation in History,â The Journal of Philosophy, Vol. 49, No. 3, (1952), 68. 2 Paul K. Conklin, âCausation Revisited,â History and Theory, Vol.13, No. 1, (1974), 1. into a hierarchy of importance. of history, there is little consensus on the precise role it should play.