About 3%-5% of people become carriers of the bacteria after the acute illness. Others suffer a very mild illness that goes unrecognized. These people may become long-term carriers of the bacteria -- even though they have no symptoms -- and be the source of new outbreaks of typhoid fever for many years.thers suffer a very mild illness that goes unrecognized. These people may become long-term carriers of the bacteria -- even though they have no symptoms -- and be the source of new outbreaks of typhoid fever for many years.
This is the parent strand of DNA which runs in the 3' to 5' direction toward the fork, and it's able to be replicated continuously by DNA polymerase. The other strand is called the lagging strand. This is the parent strand which runs in the 5' to 3' direction toward the fork, and it's replicated discontinuously. Now let's talk about the difference between continuous and discontinuous replication.
The looping of the template for the lagging strand enables a dimeric DNA polymerase III holoenzyme at the replication fork to synthesize both daughter strands. (Courtesy of A. Kornberg. From L. Stryer, Biochemistry, 4th ed.he 3â²âââ5â² exonuclease action of DNA polymerase III. Note that this exonuclease activity takes place at the 3â² end of the growing strand (and is therefore 3â²âââ5â²). The coordination of exonuclease activity with strand growth helps to explain why replication is in the 5â²âââ3â² direction.