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Driving distance from Winston-Salem, NC to Durham, NC. The total driving distance from Winston-Salem, NC to Durham, NC is 80 miles or 129 kilometers. Your trip begins in Winston-Salem, North Carolina. It ends in Durham, North Carolina.
How far is Charlotte NC to Boone NC? 100 miles taking this route:Take I-85 SOUTH to U.S. 321 to GASTONIA and LINCOLNTON at EXIT 17.Turn left off the exit ramp onto U.S. 321 NORTH towards LINCOLNTON.