Doors 32 Documentation. Our longstanding and much loved Doors32 Software is now available only via download from Keri's web site or special order, but is still free of charge. It will continue to be available as long as customers ask for it and computers with compatible operating systems exist.
Cell biology The reduction of a cellâs response to a hormone or other ligand by internalizing its cognate receptor and degrading it within a coated pit; downregulation is a mechanism by which receptors respond to an excess of ligands.
Second region âthat generates a signal when the hormone binds to it. The dual function of binding and coupling (signal generation) ultimately defines a receptor. It is the coupling of hormone binding to signal transduction called, receptor â effector coupling.This is the first step in the amplification of hormonal response. This dual purpose also distinguishes the receptor from the plasma protein that also bind hormone but do not generate signal.Chemical Nature of Receptor. Receptors are proteins. Several classes of peptide receptors have been identified.ormone âreceptor interaction occurs that results in the generation of an intracellular signal. Intracellular signal can either regulate the activity of a select set of genes, leading to alteration in the amount of certain proteins in the target cell.