Our world headquarters located in Ada, Michigan, USA, stretches one mile from east to west and is comprised of 80 buildings and 3.5 million square feet of office and manufacturing space. More than 4,000 of our 21,000 global employee family work in Ada, the same small town where Amway began over 50 years ago.
Depression is a rare side effect that has been reported in less than 1 percent of people taking the medication. Side effects are possible when taking simvastatin (Zocor Â®). One rare side effect, occurring in less than 1 percent of people who take the drug, is depression.
For patients taking amlodipine and simvastatin 40mg consider: 1  1. reducing simvastatin dose to 20mg - most patients can be managed this way as the interaction with amlodipine leads to an increase in simvastatin exposure that is similar to taking simvastatin 40mg alone. 2. Staying on simvastatin 40mg - discuss the risks and benefits of this 'off-label' option with the patient. atorvastatin (20mg or 40mg daily) is an option if a more potent statin is needed. 4. Change to an alternative calcium channel blocker - do not change therapy in patients who are well controlled with amlodipine.