The immune system can distinguish between normal, healthy cells and unhealthy cells by recognizing a variety of danger cues called danger-associated molecular patterns (DAMPs). Cells may be unhealthy because of infection or because of cellular damage caused by non-infectious agents like sunburn or cancer.he immune system can distinguish between normal, healthy cells and unhealthy cells by recognizing a variety of danger cues called danger-associated molecular patterns (DAMPs). Cells may be unhealthy because of infection or because of cellular damage caused by non-infectious agents like sunburn or cancer.
Time-weighted return. The time-weighted return (TWR) (or true time-weighted rate of return (TWRR)) is a method of calculating investment return. To apply the time-weighted return method, combine the return over sub-periods, by compounding them together, resulting in the overall period return. The rate of return over each different sub-period is weighted according to the duration of the sub-period.
It then calculates the cumulative return and the average return in three ways -- first the numeric average of the numbers you enter, and then the cumulative return divided by the number of years, and finally by taking the cumulative return and finding the single rate that would compound to that cumulative amount over your time period.