The dermis is tightly connected to the epidermis through a basement membrane. Structural components of the dermis are collagen, elastic fibers, and extrafibrillar matrix. It also contains Mechanoreceptors that provide the sense of touch and thermoreceptors that provide the sense of heat.part from these cells, the dermis is also composed of matrix components such as collagen (which provides strength), elastin (which provides elasticity), and extrafibrillar matrix, an extracellular gel-like substance primarily composed of glycosaminoglycans (most notably hyaluronan), proteoglycans, and glycoproteins.
Ischemia is a condition in which the blood flow (and thus oxygen) is restricted or reduced in a part of the body. Cardiac ischemia is the name for decreased blood flow and oxygen to the heart muscle. What is ischemic heart disease? It's the term given to heart problems caused by narrowed heart arteries.
In most cases of ischemia, this temporary blood shortage to the heart causes pain in the chest (called angina pectoris). In certain other cases, there is no pain (called silent ischemia). Ischemic cardiomyopathy is the loss or weakening of heart muscle tissue caused by ischemia or silent ischemia.