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Several antibiotics are currently used to treat UTIs. If you have a UTI that does not involve your kidneys, your doctor may prescribe one of several drugs, such as: 1  Macrobid (nitrofurantoin monohydrate)  Bactrim (trimethoprim and sulfamethoxazole)
Two of the best over the counter uti medicine include AZO Urinary Pain Relief and AZO Urinary Pain Relief Maximum Strength. Both contain phenazopyridine hydrochloride which is a compound specifically recommended by doctors for relieving pain, burning and fever.