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In the process, the nucleus of an egg is inserted into the cytoplasm of an egg from a donor female which has had its nucleus removed, but still contains the donor female's mtDNA. The composite egg is then fertilized with the male's sperm.
â¢ Mitochondrial DNA is smaller than nuclear DNA. â¢ Each mitochondrion contains thousands of mitochondrial DNA copies, but only a few copies of nuclear DNA exist in a human cell nucleus. â¢ Unlike nuclear DNA, all mitochondrial DNA comes from the mother and none comes from the father (maternally inherited).Nuclear DNA contains more information coming from both parents (both paternal and maternal).â¢ Unlike nuclear DNA, mitochondrial DNA can only be used to determine maternal lineage in an individual or a group, and it cannot be used to determine paternal lineage.â¢ Mitochondrial DNA may not be closely correlated to an individualâs fitness from other populations as nuclear DNA. Unlike nuclear DNA, all mitochondrial DNA comes from the mother and none comes from the father (maternally inherited). Nuclear DNA contains more information coming from both parents (both paternal and maternal).