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Eighteen male patients with primary syphilis were randomly assigned to one of the following treatment schedules: ceftriaxone (3 g in a single intramuscular [im] injection), ceftriaxone (2 g im daily for two days), ceftriaxone (2 g im daily for five days), and benzathine penicillin (2.4 X 10(6) units in a single im injection).
In general, a person can no longer transmit syphilis 24 hours after starting treatment. Some people, however, do not respond to the usual doses of penicillin, so it is important that your health care provider advises individuals on when it is safe for them to commence unprotected sex.