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Driving distance from Winston-Salem, NC to Durham, NC. The total driving distance from Winston-Salem, NC to Durham, NC is 80 miles or 129 kilometers. Your trip begins in Winston-Salem, North Carolina. It ends in Durham, North Carolina.
Salem is bordered by the city of Roanoke and is included in the Metropolitan Statistical Area. The city is located approximately 120 miles (190 km) from Charlottesville, 104 miles (167 km) from Greensboro, North Carolina, and 250 miles (400 km) from Knoxville, Tennessee. Roanoke College is located in the city.