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Darier's sign is a change observed after stroking the skin of a person with systemic mastocytosis or urticaria pigmentosa.In general, the skin becomes swollen, itchy and red.arier's sign is a change observed after stroking the skin of a person with systemic mastocytosis or urticaria pigmentosa. In general, the skin becomes swollen, itchy and red.
1 Pseudo-Darier's sign: It is a transient piloerection and elevation or increased induration of a lesion induced by rubbing and is observed in congenital smooth muscle hamartomas. 2  A positive pseudo-Darier's sign can be helpful in clinically distinguishing congenital smooth muscle hamartoma from congenital hairy nevus. Pseudo-Darier's sign: It is a transient piloerection and elevation or increased induration of a lesion induced by rubbing and is observed in congenital smooth muscle hamartomas. 2  A positive pseudo-Darier's sign can be helpful in clinically distinguishing congenital smooth muscle hamartoma from congenital hairy nevus.