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Driving distance from Winston-Salem, NC to Durham, NC. The total driving distance from Winston-Salem, NC to Durham, NC is 80 miles or 129 kilometers. Your trip begins in Winston-Salem, North Carolina. It ends in Durham, North Carolina.
The distance between Wilmington and Winston Salem in a straight line is 188 miles or 302.49 Kilometers. Driving Directions & Drive Times from Wilmington to Winston Salem can be found further down the page. Driving distances, maps and journey times are currently provided by Google mapping systems.