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1 Skin diseases like eczema and scabies can also cause red itchy palms. 2  Bumps and exfoliation of palmer skin is observed in these conditions. 3  Bacterial and fungal infection of palms can be a reason for itchy palms. 4  Dry skin of palms can be a reason for itchy palms.
Depending on the underlying cause of your blotchy palms, you may notice accompanying symptoms. Other possible symptoms include texture changes in the skin, such as dryness, bumps, blisters, swelling or cracking.