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Common simvastatin side effects may include: 1  headache; 2  constipation, nausea, stomach pain; or. 3  cold symptoms such as stuffy nose, sneezing, sore throat.
For patients taking amlodipine and simvastatin 40mg consider: 1  1. reducing simvastatin dose to 20mg - most patients can be managed this way as the interaction with amlodipine leads to an increase in simvastatin exposure that is similar to taking simvastatin 40mg alone. 2. Staying on simvastatin 40mg - discuss the risks and benefits of this 'off-label' option with the patient. atorvastatin (20mg or 40mg daily) is an option if a more potent statin is needed. 4. Change to an alternative calcium channel blocker - do not change therapy in patients who are well controlled with amlodipine.