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Eighteen male patients with primary syphilis were randomly assigned to one of the following treatment schedules: ceftriaxone (3 g in a single intramuscular [im] injection), ceftriaxone (2 g im daily for two days), ceftriaxone (2 g im daily for five days), and benzathine penicillin (2.4 X 10(6) units in a single im injection).
People who are being treated for syphilis must abstain from sexual contact until the infection is completely gone. Sexual partners of people with syphilis should be tested and, if necessary, treated. What if Syphilis Is not Treated? If syphilis is left untreated, it can cause serious and permanent problems such as dementia, blindness, or death.