Adenocarcinoma of the esophagus, the cancer that is especially associated with Barrett's esophagus, is currently the most rapidly rising cancer in the U.S., with a sixfold increase in cases during the past 30 years, according to the National Cancer Institute.
For other uses, see Nero Wolfe (disambiguation). Nero Wolfe is a fictional character, a brilliant, oversize, eccentric armchair detective created in 1934 by American mystery writer Rex Stout. Wolfe was born in Montenegro and keeps his past murky.
The name dire wolf (Latin: âCanis dirus â) is given to an actual species of Pleistocene megafauna that once existed on real-life Earth, like the mammoth and sabertooth cat. Dire wolves inhabited the Americas, from 1.8 million years ago to about 10,000 years ago.Note that the name of the real-life animal is spelled as two words, dire wolf, but that the name in the A Song of Ice and Fire novels is consistently spelled as one word, direwolf.The large Pleistocene mammals went extinct when the last ice age ended, roughly 10,000 years ago.irewolves are an unusually large and intelligent species of wolf. A grey direwolf on a white field is the sigil of House Stark.