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You may think diabetes only affects your blood sugar, but it can also cause poor circulation in certain areas of your body. This includes cramping in your legs, as well as pain in your calves, thighs, or buttocks. This cramping may be especially bad when youâre physically active.
1 Muscle Tension Anxiety causes a considerable amount of muscle tension, and muscle tension can lead to both cramping and spasms. 2  Muscle tension is a lot like exercise-it tires out the muscles and causes them to spasm as a result.hese types of worries are a side effect of anxiety. Anxiety can also cause their own muscle spasms. The most common reasons for spasms include: 1  Muscle Tension Anxiety causes a considerable amount of muscle tension, and muscle tension can lead to both cramping and spasms.