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Dose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.One of the attractions of this medication is its long 'half-life' - it stays in the system for days & weeks.ose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.
As with allopurinol treatment, the dose should be slowly increased. The recommended dose of probenecid is 250 mg, twice daily, for the first week, increasing to 500 mg, twice daily, for the second week and then increasing by 500 mg in subsequent months to a maximum of 2000 mg, daily in divided doses.oncurrent administration of low dose NSAIDs (e.g. naproxen 250 mg, twice daily) or colchicine (0.5 mg daily or twice daily) during this two week period, and for the following three to six months (or longer in tophaceous gout), is strongly recommended to help prevent flares.