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Dose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.One of the attractions of this medication is its long 'half-life' - it stays in the system for days & weeks.ose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.
Here are the three most common antimalarial drugs prescribed for lupus: 1  Hydroxychloroquine (Plaquenil): This is the most commonly prescribed antimalarial because it is generally believed to cause fewer side effects than the others.( 2 Learn about side effects further down in this blog).ow to use Plaquenil. Lupus and/or rheumatoid arthritis patients will most likely take this medication by mouth, usually once or twice daily or as directed. Hydroxychloroquine generally is given to adults in doses of 200 mg or 400 mg per day. In some cases, higher doses can be used.