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Definition of CEREBRAL HEMISPHERE. : either of the two hollow convoluted lateral halves of the cerebrum â see brain illustration.
For the scientific journal, see Cerebral Cortex (journal). The cerebral cortex is the outer layer of neural tissue of the cerebrum of the brain, in humans and other mammals. It is separated into two cortices, by the longitudinal fissure that divides the cerebrum into the left and right cerebral hemispheres. The two hemispheres are joined beneath the cortex by the corpus callosum.