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These drugs lower the white blood cell count to a greater degree than the counts of other blood cells â red blood cells and platelets â although these are commonly affected, too. Fortunately, the effect of these drugs on the white blood cell count is usually both predictable and short-lived. The white cell count generally falls below the normal range about seven to ten days after a chemotherapy treatment and recovers within about a week after that.
Smoking is well documented to increase the white cell count especially neutrophils. Although a higher than 11,000 white cells/mcl of blood is considered high, in leukemias the white blood cell counts can reach 100,000. An elevated ESR, LDH or CRP would be helpful and would make inflammatory changes more likely although not conclusive.