The cartilage rings are C-shaped because the back of the trachea presses against the esophagus. The cartilage opens at the esophagus and is replaced by connective tissue and muscle. This gives the esophagus space to allow food to be swallowed easily. The rings of the trachea are stacked one on top of the other, with a small space between them.
In 2014, a survey of the Australian working population revealed that the most common carcinogenic exposures in the workplace were solar ultraviolet radiation, diesel engine exhaust, environmental tobacco (second-hand) smoke, benzene, lead and silica.
Exposure to several carcinogens at once may result in cancer rates higher than would be expected by adding the risks from each carcinogen separately. This is known as a synergistic effect. For example, both cigarette smoking and exposure to asbestos have been show to cause cancer.