Definition of TISSUE PLASMINOGEN ACTIVATOR. : a clot-dissolving enzyme with an affinity for fibrin that is produced naturally in blood vessel linings and is used in a genetically engineered form to prevent damage to heart muscle following a heart attack and reduce neurological damage following ischemic stroke âabbreviation TPA.ADVERTISEMENT. a clot-dissolving enzyme with an affinity for fibrin that is produced naturally in blood vessel linings and is used in a genetically engineered form to prevent damage to heart muscle following a heart attack and reduce neurological damage following ischemic stroke âabbreviation TPA. ADVERTISEMENT.
Causation principle refers to the relation between the cause or an event and the effect or a second event. The second event is the physical result of the first.      â¦ . Torrey Garcia.
any question or matter involving doubt, uncertainty, or difficulty. 2. a question proposed for solution or discussion. 3. Mathematics. a statement requiring a solution, usually by means of a mathematical operation or geometric construction.