The cartilage rings are C-shaped because the back of the trachea presses against the esophagus. The cartilage opens at the esophagus and is replaced by connective tissue and muscle. This gives the esophagus space to allow food to be swallowed easily. The rings of the trachea are stacked one on top of the other, with a small space between them.
In 2014, a survey of the Australian working population revealed that the most common carcinogenic exposures in the workplace were solar ultraviolet radiation, diesel engine exhaust, environmental tobacco (second-hand) smoke, benzene, lead and silica.
MDA is considered a potential occupational carcinogen by the US National Institute for Occupational Safety and Health. The Occupational Safety and Health Administration has set a permissible exposure limit at 0.01 ppm over an eight-hour time-weighted average, and a short-term exposure limit at 0.10 ppm.