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Definition of CEREBRAL HEMISPHERE. : either of the two hollow convoluted lateral halves of the cerebrum â see brain illustration.
The cerebral cortex is the cerebrum 's (brain) outer layer of neural tissue in humans and other mammals. It is divided into two cortices, along the sagittal plane: the left and right cerebral hemispheres divided by the medial longitudinal fissure.he cerebral cortex is gray matter, consisting mainly of cell bodies (with astrocytes being the most abundant cell type in the cortex as well as the human brain as a whole) and capillaries.