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Dose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.One of the attractions of this medication is its long 'half-life' - it stays in the system for days & weeks.ose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.
Plaquenil is available in generic form. Common side effects of Plaquenil include nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, ringing in your ears, mood changes, nervousness, irritability, skin rash, itching, or hair loss.ur Plaquenil (hydroxychloroquine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.