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Driving distance from Winston-Salem, NC to Durham, NC. The total driving distance from Winston-Salem, NC to Durham, NC is 80 miles or 129 kilometers. Your trip begins in Winston-Salem, North Carolina. It ends in Durham, North Carolina.
The major city closest to the halfway point between Wilmington, NC and Winston-Salem, NC is Fayetteville, NC, situated 88.84 miles from Wilmington, NC and 120.23 miles from Winston-Salem, NC. It would take 1 hour 49 mins to go from Wilmington to and 2 hours 25 mins to go from Winston-Salem to Fayetteville.