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Eighteen male patients with primary syphilis were randomly assigned to one of the following treatment schedules: ceftriaxone (3 g in a single intramuscular [im] injection), ceftriaxone (2 g im daily for two days), ceftriaxone (2 g im daily for five days), and benzathine penicillin (2.4 X 10(6) units in a single im injection).
When a person has a syphilis infection, they are more likely to acquire HIV from an infected sexual partner. Syphilis can increase the chances of getting HIV by 2- to 3- fold. 2 One study showed a 4-fold increase in the chance of acquiring HIV in men who have sex with men and infected with syphilis. 3.n the early latent period, no symptoms may occur, but the infection is still present in the body. By this time, the infection has spread to many different parts of the body. Without treatment, the syphilis infection may progress to late latent syphilis, also known as tertiary syphilis.