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Common simvastatin side effects may include: 1  headache; 2  constipation, nausea, stomach pain; or. 3  cold symptoms such as stuffy nose, sneezing, sore throat.
Some foods and medicines can affect how simvastatin works. Tell your doctor if you are using amiodarone, colchicine, dronedarone, lomitapide, niacin (vitamin B3), ranolazine, a blood thinner (such as warfarin), or blood pressure medicine (such as amlodipine, diltiazem, verapamil).imvastatin belongs to the group of medicines called HMG-CoA reductase inhibitors, or statins. It works to reduce the amount of cholesterol in the blood by blocking an enzyme that is needed to make cholesterol. This medicine is available only with your doctor's prescription. Other uses (PubMed Health).