The immune system can distinguish between normal, healthy cells and unhealthy cells by recognizing a variety of danger cues called danger-associated molecular patterns (DAMPs). Cells may be unhealthy because of infection or because of cellular damage caused by non-infectious agents like sunburn or cancer.he immune system can distinguish between normal, healthy cells and unhealthy cells by recognizing a variety of danger cues called danger-associated molecular patterns (DAMPs). Cells may be unhealthy because of infection or because of cellular damage caused by non-infectious agents like sunburn or cancer.
Time-weighted return. The time-weighted return (TWR) (or true time-weighted rate of return (TWRR)) is a method of calculating investment return. To apply the time-weighted return method, combine the return over sub-periods, by compounding them together, resulting in the overall period return. The rate of return over each different sub-period is weighted according to the duration of the sub-period.
The time-weighted return for Riskco is the same for both Barry and Samantha. (After all, both investors were part of the same pool of commingled funds). In addition, Samanthas returns are identical to her dollar-weighted return, since there were no additional cash flows after her initial investment.