Doors 32 Documentation. Our longstanding and much loved Doors32 Software is now available only via download from Keri's web site or special order, but is still free of charge. It will continue to be available as long as customers ask for it and computers with compatible operating systems exist.
Cell biology The reduction of a cellâs response to a hormone or other ligand by internalizing its cognate receptor and degrading it within a coated pit; downregulation is a mechanism by which receptors respond to an excess of ligands.
Receptors for peptide hormones tend to be found on the plasma membrane of cells, whereas receptors for lipid-soluble hormones are usually found within the cytoplasm. Upon hormone binding, the receptor can initiate multiple signaling pathways which ultimately lead to changes in the behaviour of the target cells.teroid hormone receptors and related receptors are generally soluble proteins that function through gene activation. Their response elements are DNA sequences (promoters) that are bound by the complex of the steroid bound to its receptor. The receptors themselves are zinc-finger proteins.