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Dose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.One of the attractions of this medication is its long 'half-life' - it stays in the system for days & weeks.ose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.
I had side effects for about 2 week when first taking Plaquenil. I got headaches, sneezing, runny nose etc for about 1/2 hour each time I took it but persevered and so glad I did. 8 years on I am on a maintenance dose of 200mg with no side effects whatsoever. few weeks after I stopped Plaquenil, I met two people who had Lupus and had been on Plaquenil. They both stopped the drug because of side effects that included anxiety, extreme irritability, being very emotional. One of these people also had pressure build up behind her eyes which her doctor attributed to Plaquenil.