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Darier's sign is a change observed after stroking the skin of a person with systemic mastocytosis or urticaria pigmentosa.In general, the skin becomes swollen, itchy and red.arier's sign is a change observed after stroking the skin of a person with systemic mastocytosis or urticaria pigmentosa. In general, the skin becomes swollen, itchy and red.
INTRODUCTION. Darier disease, also known as Darier-White disease or keratosis follicularis (MIM #1242000), is a rare autosomal dominant genodermatosis.It is characterized by a persistent eruption of greasy hyperkeratotic papules in seborrheic areas, nail abnormalities, and mucosal changes [ 1 ].NTRODUCTION. Darier disease, also known as Darier-White disease or keratosis follicularis (MIM #1242000), is a rare autosomal dominant genodermatosis.