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Dose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.One of the attractions of this medication is its long 'half-life' - it stays in the system for days & weeks.ose. The normal dose of Plaquenil is 1 tablet a day (200mg/day). Some doctors recommend 2 a day (400mg/day) but we find that 1 a day suits most people-the dose can always be increased for a flare.
Plaquenil Overdose. Since a Plaquenil (hydroxychloroquine) overdose can be lethal, it is important to seek medical attention immediately if you think you may have taken too much of the medication. Vision changes, seizures, or cardiac arrest may also occur as a result of taking too much Plaquenil.