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Eighteen male patients with primary syphilis were randomly assigned to one of the following treatment schedules: ceftriaxone (3 g in a single intramuscular [im] injection), ceftriaxone (2 g im daily for two days), ceftriaxone (2 g im daily for five days), and benzathine penicillin (2.4 X 10(6) units in a single im injection).
When syphilis has spread throughout the body, the person may have: 1  A fever of usually less than 101Â°F (38.3Â°C). 2  A sore throat. 3  A vague feeling of weakness or discomfort throughout the body.  Weight 1  loss. Patchy hair loss, especially in the eyebrows, eyelashes, and scalp hair.  Swelling of the lymph nodes.