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Driving distance from Winston-Salem, NC to Durham, NC. The total driving distance from Winston-Salem, NC to Durham, NC is 80 miles or 129 kilometers. Your trip begins in Winston-Salem, North Carolina. It ends in Durham, North Carolina.
How many miles is it from Columbia SC to Winston Salem NC? 170 miles taking this route: Take I-77 NORTH (towards CHARLOTTE), from Columbia, to I-85 NORTH to GREENSBORO at EXIT 13A in Charlotte, NORTH CAROLINA.Take I-85 NORTH to U.S. â¦52 to WINSTON-SALEM at EXIT 87, near Lexington.