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Common simvastatin side effects may include: 1  headache; 2  constipation, nausea, stomach pain; or. 3  cold symptoms such as stuffy nose, sneezing, sore throat.
co-morbidities, including liver function, following a change in therapy monitor patients for efficacy and adverse effects; Pharmokinetics of interaction: simvastatin is metabolised by the cytochrome P-450 isoenzyme CYP3A4 and is very sensitive to the effects of CYP3A4 inhibitors, leading to many well recognised drug interactions amlodipine is a weak inhibitor of CYP3A4