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Several antibiotics are currently used to treat UTIs. If you have a UTI that does not involve your kidneys, your doctor may prescribe one of several drugs, such as: 1  Macrobid (nitrofurantoin monohydrate)  Bactrim (trimethoprim and sulfamethoxazole)
Bactrim works against bacteria in the following types of infections: 1  Urinary tract infections (UTIs) caused by E. coli, Klebsiella, Enterobacter, Morganella morganii, Proteus mirabilis, and Proteus vulgaris.actrim is the brand name of the generic antibiotic sulfamethoxazole trimethoprim (sometimes called co-trimoxazole). The drug is a combination of two antibiotics: It's one part trimethoprim (a synthetic drug), and five parts sulfamethoxazole (a sulfonamide drug).