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I can't tell you how long the initial breakout will last, because your skin is not the same as mine. I will say that you should give it the 12 weeks. The manufacturer says it may take up to 12 weeks, so until 12 weeks have passed, you can't reach a real verdict.'m currently using Epiduo which is a mixture of Adapalene (Differin) and Benzoyl Peroxide. My initial breakout started after a week of using the cream and I'm still going through it-and I've been using it for four weeks now. As far as I know this is normal and I heard it can last anything between two and six weeks.
How Long Does A Herpes Outbreak Last. Genital herpes is a sexually transmitted disease (STD). Women are more commonly infected than men. For women who have sores, the first outbreak may last two to four weeks.Another outbreak can occur in weeks or months.One in five American adults has herpes, but only one third of those inflicted are aware that they have the virus.enital herpes is a sexually transmitted disease (STD). Women are more commonly infected than men. For women who have sores, the first outbreak may last two to four weeks.