The syndrome is caused by the misfolding of fibrillin-1, a glycoprotein which forms elastic fibers in connective tissue and contributes to cell signaling activity by binding to and sequestering transforming growth factor beta (TGF-Î²).arfan syndrome is caused by mutations in the FBN1 gene on chromosome 15, which encodes fibrillin-1, a glycoprotein component of the extracellular matrix.
pomegranate meaning, definition, what is pomegranate: a round, thick-skinned fruit containing a mass of red seeds and a lot of juice. Learn more.
Definitions: 1  pomegranate. 2  Age: Latin not in use in Classical times (6-10th centuries) Christian. 3  Area: Agriculture, Flora, Fauna, Land, Equipment, Rural.  Geography: All or 1  none. Frequency: For Dictionary, in top 10,000 words.  Source: Lewis & Short, âA Latin Dictionaryâ, 1879 (Lewis & Short)