The syndrome is caused by the misfolding of fibrillin-1, a glycoprotein which forms elastic fibers in connective tissue and contributes to cell signaling activity by binding to and sequestering transforming growth factor beta (TGF-Î²).arfan syndrome is caused by mutations in the FBN1 gene on chromosome 15, which encodes fibrillin-1, a glycoprotein component of the extracellular matrix.
pomegranate meaning, definition, what is pomegranate: a round, thick-skinned fruit containing a mass of red seeds and a lot of juice. Learn more.
Seeding a Pomegranate. 1  Cut the crown (protruding blossom end) off the pomegranate, removing with it some of the pale-yellow pith. 2  Take care not to pierce the seeds within. 3  Lightly score the skin in quarters from stem to crown end. 4  Immerse the scored fruit in a large bowl of cool water and soak for 5 minutes.