NEW YORK (Reuters Health) â Long-term treatment of systemic lupus erythematosus (SLE) with hydroxychloroquine, initiated soon after disease onset, is protective against renal damage, according to study findings presented this week at the American College of Rheumatology Annual Scientific Meeting in San Francisco.
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One of the hallmarks of lupus are low Complement 3 (C3) and Complement 4 (C4) levels. Low C3 is not specific to lupus; low C3 combined with low C4 is what is usually seen in lupus. The patientâs levels of C3 and C4 can indicate the activity of the disease. 1  When C3 and C4 levels are low, it can suggest that the disease is active and there is either a current flare or a flare is imminent.