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Eighteen male patients with primary syphilis were randomly assigned to one of the following treatment schedules: ceftriaxone (3 g in a single intramuscular [im] injection), ceftriaxone (2 g im daily for two days), ceftriaxone (2 g im daily for five days), and benzathine penicillin (2.4 X 10(6) units in a single im injection).
Antibiotics for syphilis. A short course of antibiotics can usually cure syphilis. These are only available on prescription, so you'll need to be tested for syphilis to get them. The type of treatment you need depends on how long you've had syphilis. 1  Syphilis that has lasted less than two years is usually treated with an injection of penicillin into your buttocks, or a 10-14 day course of antibiotic tablets if you can't have penicillin.