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1 Believe it or not, hair loss (alopecia) due to chemotherapy is one of the most distressing side effects of chemo treatments.  Hair loss happens because the chemotherapy affects all cells in the body, not just the cancer cells. The lining of the mouth, stomach, and the hair follicles are especially sensitive because those cells multiply rapidly just like the cancer cells.
It may be that hair loss is a potential side effect of your medication. Types of Medications That Can Cause Hair Loss. The reason that some medications cause you to lose your hair is that they are toxic to the hair follicles â the cells responsible for hair growth. When hair follicles become damaged, the normal cycle of hair growth is disrupted, which eventually leads to hair loss.