According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
The Queen may have overtaken Victoriaâs reign of 63 years and 216 days, but she ranks just 48th in the league table of longest verifiable rulers. King Sobhuza II of Swaziland, who spent 82 years 253 days on the throne of the small southern African kingdom, claims top spot.