The Cavitron Ultrasonic Surgical Aspirator is a unique modality for precise tissue removal which results in increased visibility, reduced bleeding, and shorter operating time when dealing with vascular lesions or organs.
The SOD1 mouse develops an ALS-like disease that researchers hope overlaps enough with human ALS that mouse responses to treatment might predict human responses. SOD1 gene mutations, however, cause a familial (inherited) form of human ALS thatâs present in only 1 percent to 3 percent of ALS cases. For some 90 percent of patients, the disease isnât familial. Its onset is unpredictable (sporadic) and the cause is unknown.
Sporadic and Familial ALS. Most cases of ALS are âsporadic,â meaning they are due to no known cause. Approximately 5-10% of cases are due to known genetic mutations. In most of those cases, another family member also has ALS or a related disease (see C9ORF72 below).9ORF72. This gene, discovered in 2011, is the most common genetic cause of ALS. (Its name refers to the position of an âopen reading frameâ on chromosome 9). Mutations in this gene account for between 25% and 40% of all familial ALS cases (depending on the population), and also approximately 4% to 6% of sporadic cases.