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1 Gonorrhea and chlamydia are the most common causes of epididymitis in young, sexually active men. 2  Other infections. 3  For boys and men who aren't sexually active, epididymitis can be caused by a nonsexually transmitted bacterial infection.
Majority of the cases of Epididymo-Orchitis are due to infection. Epididymo-Orchitis Caused By Urinary Tract Infection: Some bacteria like the E. coli which causes urine infections at times get to the vas deferens and lead to development of Epididymo-Orchitis.