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Accutane side effects. Get emergency medical help if you have any of these signs of an allergic reaction to Accutane: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. joint stiffness, bone pain or fracture. cracking or peeling skin, itching, rash, changes in your fingernails or toenails.
If acne doesnât respond to birth control pills alone, your doctor may add medication to lower testosterone levels. This medication, called spironolactone, curbs testosterone-related oil production in the skin. Side effects include breast tenderness, irregular periods, headaches, and fatigue.