morphine). Since diffusion across a lipid bilayer requires that a drug be lipid-soluble, the ionized form of a drug cannot cross membranes. Thus, weak acids that are nonprotonated and weak bases that are protonated cannot diffuse across membranes. At a pH that is equal to a drugâs pKa, equal amounts of the protonated and nonprotonated forms are present. Assuming the pH is the same on both sides of a given membrane, the drug will be at equilibrium across the membrane.
Ledyba (Japanese: ã¬ãã£ã Rediba) is a Bug/Flying-type PokÃ©mon introduced in Generation II. Ledyba is a common Bug type PokÃ©mon that resembles a ladybug. It has six legs, that are all wearing gloves.
Whirlipede (Japanese: ãã¤ã¼ã¬ Hoiiga) is a Bug/Poison-type PokÃ©mon introduced in Generation V. Whirlipede is a large arthropod PokÃ©mon that resembles a curled-up centipede. Its rolled-up body is segmented. It is mainly purple and black with long spine-like appendages on its front and lower body. Its body is covered in smaller purple spikes. In the center of its body is its large yellow eye. It has light purple scales; on these scales are small red circles. Its curled-up body gives it the appearance of a tire.