According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
UK's longest-reigning monarch, but Queen ranks only 48th in world. Leaders of Holy Roman empire states dominate the global top 10 but the longest-ever ruler was King Sobhuza II of Swaziland, at 82 years and 253 days. The Queen has overtaken Victoriaâs reign of 63 years and 216 days Photograph: Rex Shutterstock.