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drug used in the treatment of abnormal heart rhythms (arrhythmia) and malaria. Obtained from the bark of the Cinchona tree, quinidine shares many of the pharmacological actions of quinine; i.e., both have antimalarial and fever-reducing activity. The main use of quinidine, however, involves its...
Quinine was the first effective Western treatment for malaria caused by Plasmodium falciparum, appearing in therapeutics in the 17th century.It remained the antimalarial drug of choice until the 1940s, when other drugs, such as chloroquine, that have fewer unpleasant side effects replaced it.uinine can, in therapeutic doses, cause cinchonism; in rare cases, it may even cause death (usually by pulmonary edema). The development of mild cinchonism is not a reason for stopping or interrupting quinine therapy, and the patient should be reassured.