Acne is the most common skin condition in the United States, affecting up to 50 million Americans annually. 1; Acne often causes significant physical and psychological problems such as permanent scarring, poor self-image, depression and anxiety. 2; See your dermatologist for the successful diagnosis and treatment of acne.
Mechanism of action. It is a phosphodiesterase-4 inhibitor, mainly acting on phosphodiesterase 4B (PDE4B), which causes inflammation. Chemically, crisaborole is a phenoxybenzoxaborole. It contains a boron atom that helps penetrate the skin and is essential for its binding activity.
Diclofenac Sodium: Topical gel. NSAIDs reduce pain, inflammation and swelling while helping the body return to a normal temperature. When the body is injured or ill, it releases an enzyme known as COX. NSAIDs help control two specific types of COX enzymes, COX-1 and COX-2.