Acne is the most common skin condition in the United States, affecting up to 50 million Americans annually. 1; Acne often causes significant physical and psychological problems such as permanent scarring, poor self-image, depression and anxiety. 2; See your dermatologist for the successful diagnosis and treatment of acne.
Mechanism of action. It is a phosphodiesterase-4 inhibitor, mainly acting on phosphodiesterase 4B (PDE4B), which causes inflammation. Chemically, crisaborole is a phenoxybenzoxaborole. It contains a boron atom that helps penetrate the skin and is essential for its binding activity.
A vaginal gel preparation of metronidazole is also available in some countries to treat bacterial vaginosis. How does metronidazole work? Metronidazole is an antiprotozoal and anaerobic antibacterial agent. When administered systemically via oral tablets or injection, metronidazole works by inhibiting bacterial DNA synthesis hence preventing the replication of bacteria.