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Definition of computation. 1  1a : the act or action of computing : calculationb : the use or operation of a computer. 2  2 : a system of reckoning. 3  3 : an amount computed.
from Wikipedia, the free encyclopedia. Computational Neuroscience is an interdisciplinary science that links the diverse fields of neuroscience, computer science, physics and applied mathematics together. It serves as the primary theoretical method for investigating the function and mechanism of the nervous system.