According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
Early Life. Japan's longest-reigning monarch, Emperor Hirohito, was born Michinomiya Hirohito on April 29, 1901, in the Aoyama Palace in Tokyo, Japan. He was the first son of Crown Prince Yoshihito (later Emperor Taisho) and Princess Sadako (later Empress Teimei).