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Accutane side effects. Get emergency medical help if you have any of these signs of an allergic reaction to Accutane: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. joint stiffness, bone pain or fracture. cracking or peeling skin, itching, rash, changes in your fingernails or toenails.
The drug also can cause very serious side effects, including severe birth defects if taken during pregnancy; suicidal thoughts or tendencies; liver damage; and pancreatitis. Due to the large number of serious and possibly fatal side effects, the FDA has placed several warnings and advisories on Depakote.