According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
Longest Reigning European Monarchs. The above list includes only rulers of empires and kingdoms. Afonso I of Portugal (1109-1185) reigned as Count of Portugal from 1112, and as King from 1139. Prince Johann II of Liechtenstein reigned 71 years (1858-1929). His was the longest reign of any sovereign in history that did not require a regency as he was already 18 at his accession. Friedrich August III (I) of Saxony reigned for over 63 years (1763-1827), from 1763 to 1806 as Elector and from 1805 to his death as King.