According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
The following is a list, ordered by length of reign, of the monarchs of the United Kingdom of Great Britain and Northern Ireland, the United Kingdom of Great Britain and Ireland, the Kingdom of Great Britain, the Kingdom of England, the Kingdom of Scotland, the Kingdom of Ireland, and the Principality of Wales. Queen Elizabeth II became the longest-reigning British monarch on 9 September 2015 when she surpassed the reign of her great-great-grandmother Victoria. On 6 February 2017 she became the first British monarch to celebrate a sapphire jubilee, commemorating 65 years on the throne.