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The most common causes of lymph node and neck pain are infection of some variety, though swelling and inflammation owing to injury elsewhere may also be to blame. At least in humans, some of the most prominent lymph nodes are located just behind the sinuses and in the soft tissues of the neck and upper throat.
Because swelling is sometimes a sign of cancer, it is also important to see your doctor to be sure the cancer has not come back. Causes of lymphedema. Lymphedema is usually a predictable long-term side effect of some cancer treatments. The most common causes of lymphedema in cancer survivors include: Surgery in which lymph nodes were removed. For example, surgery for breast cancer often involves removing 1 or more lymph nodes under the arm to check for cancer. This can cause lymphedema in the arm. Radiation therapy or other causes of inflammation or scarring in the lymph nodes and lymph vessels. Blockage of the lymph nodes and/or lymph vessels by the cancer. The risk of lymphedema increases with the number of lymph nodes and lymph vessels removed or damaged during cancer treatment or biopsies.