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The most common causes of lymph node and neck pain are infection of some variety, though swelling and inflammation owing to injury elsewhere may also be to blame. At least in humans, some of the most prominent lymph nodes are located just behind the sinuses and in the soft tissues of the neck and upper throat.
Lymph nodes become swollen in response to illness, infection, or stress. Swollen lymph nodes are one sign that your lymphatic system is working to rid your body of the responsible agents. More serious conditions, such as immune system disorders or cancers, can cause the lymph nodes throughout the body to swell. Immune system disorders that cause the lymph nodes to swell include lupus and rheumatoid arthritis. Any cancers that spread in the body can cause the lymph nodes to swell. When cancer from one area spreads to the lymph nodes, the survival rate decreases. Lymphoma, which is a cancer of the lymphatic system, also causes the lymph nodes to swell. Some medications and allergic reactions to medications can cause the lymph nodes to swell. Anti-seizure and antimalarial drugs can also cause lymph nodes to swell.