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1 Believe it or not, hair loss (alopecia) due to chemotherapy is one of the most distressing side effects of chemo treatments.  Hair loss happens because the chemotherapy affects all cells in the body, not just the cancer cells. The lining of the mouth, stomach, and the hair follicles are especially sensitive because those cells multiply rapidly just like the cancer cells.
Tamoxifen, the gold standard treatment for hormone-receptor positive breast cancer does not cause significant hair loss, but may cause some thinning. Here is a list of the most common chemotherapy drugs used to treat breast cancer with associated hair loss. Adriamycin: Complete hair loss on the head, typically during the first few weeks of treatment. Some women also experience loss of eyelashes and eyebrows.