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Quick Answer. Helicase is an enzyme that unwinds DNA strands. After it unwinds double-stranded DNA, two pairs of single-stranded DNA are available for replication, transcription and translation.
DNA Polymerase. Just as helicase is responsible for unwinding the DNA strand, DNA polymerase is responsible for replicating the strand once it unwinds and separates. DNA is made up of a sugar-phosphate ladder and a nucleotide base.s the DNA strand separates, the DNA polymerase matches nucleotide bases that are missing when the strand separates. Most DNA polymerase also has the ability to correct errors in the strand. As there is more than one type of helicase, there is also more than one type of polymerase.