These factors include. 1  Living at high latitudes (closer to the polar regions), particularly during winter months. 2  Air quality conditions: high levels of air pollution. 3  Weather conditions: dense cloud covering. 4  The degree to which clothing covers the skin. 5  Use of sunscreen. 6  Skin pigmentation: darker skin types.
A few cases of severe homocysteinemia have been due to rare MTHFR gene mutations (sometimes in combination with a second common MTHFR gene mutation). Symptoms in these patients varied greatly but often involved pronounced neurological symptoms and blood vessel disease.
Symptoms of GH deficiency in adults include the following: 1  Low energy. 2  Decreased strength and exercise tolerance. 3  Decreased muscle mass.  Weight gain, especially around the 1  waist. Feelings of anxiety, depression, or sadness causing a change in social behavior.  Thin and dry skin.