More common. 1  Headache. 2  hoarseness. 3  lower back or side pain. 4  pain or tenderness around the eyes and cheekbones. 5  painful or difficult urination. 6  stuffy or runny nose.
trazodone oral and linezolid iv both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock.
In the other case, it was reported that acute dystonia observed 2 weeks after the dose of trazodone had been increased to 50 mg/day (7). There was also no case of tardive dyskinesia reported with trazodone (5). Trazodone has generally antagonistic effect on serotonergic receptors in particular 5-HT1A, 5-HT1C and 5-HT2.