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Folate deficiency is one of the causes of macrocytic anemia. It does not cause seizures, although it may involve the central nervous system, producing neuropsychiatric complications.1. The association between folate deficiency and epilepsy involves common antiepileptic drugs (AEDs): AEDs can impair folate absorption.
The reason high folate levels are found in people who have a vitamin B12 deficiency is the body needs vitamin B12 to use folate, explains WebMD. When vitamin B12 levels are not within a normal range, the cells in the body cannot use folic acid, allowing it to build up in the bloodstream. However, a folic acid test is not the proper test to find a vitamin B12 deficiency. A low folate level can indicate diet issues, an eating disorder or alcohol dependency, according to WebMD.