According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
The longest reign of a European head of state is that of France's King Louis XIV, who also centralised government in his capital, most famously establishing and encamping the nobility under watchful eyes in his family's Palace of Versailles.