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Doxycycline. Doxycycline is an antibiotic used to treat chlamydia infection. It is used mainly as an alternative to the antibiotic azithromycin. Doxycycline is equally as effective as azithromycin, but whereas azithromycin is a single dose treatment, doxycycline treatment needs to be taken twice daily for 7 days.1  Avoid sexual contact whilst taking doxycycline and for 7 days afterwards, until no longer infectious. 2  People with a positive chlamydia test and their sexual partners should be ...lternative antibiotic. The most frequently used antibiotic for the treatment of chlamydia is azithromycin taken as a single dose. Azithromycin is preferred by most doctors and patients because it is a single dose, although it is more expensive than doxycycline.
The number of days you take antibiotics depends on your illness and the type of antibiotic medicine. Azithromycin and doxycycline cure chlamydia in up to 95 out of 100 cases. Some people may not be able to take these medicines but are able to take a different one.