Abstract. The appearance of creatine kinase (CK) in blood has been generally considered to be an indirect marker of muscle damage, particularly for diagnosis of medical conditions such as myocardial infarction, muscular dystrophy, and cerebral diseases.igure 1: Phosphocreatine (PCr) circuit showing the rephosphorylation of creatine (Cr) in mitochondria using ATP derived from oxidative phosphorylation (oxid phos) and subsequent use of mitochondrial PCr by cytosolic creatine kinase (CK) to resupply ATP for muscle activity, adapted from Saks [ 5 ].
Alterations in DNA that occur after conception. Somatic mutations can occur in any of the cells of the body except the germ cells (sperm and egg) and therefore are not passed on to children.These alterations can (but do not always) cause cancer or other diseases.omatic mutations can occur in any of the cells of the body except the germ cells (sperm and egg) and therefore are not passed on to children.
Germ-line therapy occurs when germ cells (reproductive cells) are altered, meaning that the resulting genetic changes will be passed on to the patient's offspring. Alternatively, somatic cell gene therapy involves the alteration of somatic cells (non-reproductive body cells, like skin, brain or muscle cells).This genetic manipulation will only affect the individual to which the changes were made. Somatic cell gene therapy is the only type presently being considered in humans.lternatively, somatic cell gene therapy involves the alteration of somatic cells (non-reproductive body cells, like skin, brain or muscle cells). This genetic manipulation will only affect the individual to which the changes were made. Somatic cell gene therapy is the only type presently being considered in humans.