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What layer of the skin contains melanin? The epidermis layer of the skin contains melanin producing cells, so I would assume that is the layer with melanin in it. What layer of skin produces melanin? Melanocytes, which produce melanin, are found in the basal layer of the epidermis, also called the stratum basale.
Figure 4. Layers of the Epidermis. The epidermis of thick skin has five layers: stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum. The stratum basale is a single layer of cells primarily made of basal cells.