Quoted from the NIH: Normally, the immune system helps protect the body, but with Crohn's disease the immune system can't tell the difference between normal body tissue and foreign substances. The result is an overactive immune response that leads to chronic inflammation. I have never heard someone say Crohn's isn't an autoimmune disease.
For the neonate with FMAIT, platelet transfusion is the treatment of choice and should be given to normalise the platelet count in an infant with ICH or to treat severe throbmobocytopaenia in infants without ICH. Platelets used for neonates with FMAIT should be negative for the implicated platelet-specific antigen.
There are no known significant alterations in platelet function with irradiation of 25 Gy. All transfusions must be given via blood administration sets containing 170- to 260-micron filters or 20- to 40-micron microaggregate filters unless transfusion is given via a bedside leukocyte reduction filter.