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An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system.Anticholinergics inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells.nticholinergic drugs are used to treat a variety of conditions: 1  Gastrointestinal disorders (e.g., gastritis, diarrhea, pylorospasm, diverticulitis, ulcerative colitis, nausea, and vomiting). 2  Genitourinary disorders (e.g., cystitis, urethritis, and prostatitis). 3  Respiratory disorders (e.g., asthma, chronic bronchitis, and chronic obstructive 4  .... S
However, the medications have not been rigorously compared with behavioral methods, such as bladder training and Kegel exercises, which are very effective for most cases of urge incontinence. Anticholinergics can have distressing side effects, notably dry mouth. Anticholinergics include: 1  Propantheline (ProBanthine).2  This drug used to be the most commonly prescribed anticholinergic, but has been largely replaced by newer anticholinergics with fewer side effects.hey are useful for men with benign prostatic hyperplasia who also have urge incontinence. The older alpha-blockers terazosin (Hytrin) and doxazosin (Cardura) are now prescribed less often than the newer selective alpha-blockers tamsulosin (Flomax), alfuzosin (Uroxatral), and silodosin (Rapaflo).