A GSM modem can be an external device or a PC Card / PCMCIA Card. Typically, an external GSM modem is connected to a computer through a serial cable or a USB cable. A GSM modem in the form of a PC Card / PCMCIA Card is designed for use with a laptop computer.
Entresto is supplied as a tablet for oral administration. The recommended starting dose of Entresto is 49/51 mg (sacubitril/valsartan) twice-daily. Double the dose of Entresto after 2 to 4 weeks to the target maintenance dose of 97/103 mg (sacubitril/valsartan) twice-daily, as tolerated by the patient.
It was approved under the FDA's priority review process on July 7, 2015. It is also approved in Europe. The wholesale cost for a year of Entresto is $4,560 per person as of 2015. Similar class generic drugs without sacubitril, such as valsartan alone, cost approximately $48 a year.