From Wikipedia, the free encyclopedia. Lipophobicity, also sometimes called lipophobia (from the Greek Î»Î¹ÏÎ¿ÏÎ¿Î²Î¯Î± from Î»Î¯ÏÎ¿Ï lipos fat and ÏÏÎ²Î¿Ï phobos fear), is a chemical property of chemical compounds which means  fat rejection, literally fear of fat. Lipophobic compounds are those not soluble in lipids or other non-polar solvents.
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