Nucleic acids are linear polymers (chains) of nucleotides. Each nucleotide consists of three components: a purine or pyrimidine nucleobase (sometimes termed nitrogenous base or simply base), a pentose sugar, and a phosphate group. The substructure consisting of a nucleobase plus sugar is termed a nucleoside.
Other studies of Remicade and methotrexate indicate that the two medications together can successfully reduce symptoms of psoriasis and psoriatic arthritis, the researchers report. Studies of Humira and Enbrel in conjunction with methotrexate also revealed the combination to be more effective than the biologic alone.
Why It Is Used. Methotrexate reduces inflammation caused by rheumatoid arthritis. It is the most common DMARD used to treat rheumatoid arthritis. Methotrexate may be used: 1  In the early stages of rheumatoid arthritis to prevent disease progression. 2  In combination with other medicines such as other DMARDs.all your doctor if you have: 1  Hives. 2  Signs of an infection, such as a sore throat, fever, sneezing, or coughing. 3  Bloody vomit. 4  Signs of unusual bleeding or bruising, such as black and tarry stools or blood in the urine. 5  Diarrhea. 6  Stomach pain.