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Doxycycline. Doxycycline is an antibiotic used to treat chlamydia infection. It is used mainly as an alternative to the antibiotic azithromycin. Doxycycline is equally as effective as azithromycin, but whereas azithromycin is a single dose treatment, doxycycline treatment needs to be taken twice daily for 7 days.1  Avoid sexual contact whilst taking doxycycline and for 7 days afterwards, until no longer infectious. 2  People with a positive chlamydia test and their sexual partners should be ...lternative antibiotic. The most frequently used antibiotic for the treatment of chlamydia is azithromycin taken as a single dose. Azithromycin is preferred by most doctors and patients because it is a single dose, although it is more expensive than doxycycline.
These data suggest that a single 200-mg dose of doxycycline given within 72 hours after an I. scapularis tick bite can prevent the development of Lyme disease. Doxycycline for 30 day courses has been used to treat certain cardiac, nervous system, and joint manifestations of Lyme disease. Other specific manifestations of Lyme disease are generally treated with intravenous antibiotics, most often ceftriaxone 2 gm twice daily for 14 to 30 days, and these include Lyme meningitis, neuroborreliosis, arthritis not responsive to doxycycline, and severe cardiac manifestations.