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Accutane side effects. Get emergency medical help if you have any of these signs of an allergic reaction to Accutane: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. joint stiffness, bone pain or fracture. cracking or peeling skin, itching, rash, changes in your fingernails or toenails.
Acne Drug Accutane Ups Cholesterol. Aug. 21, 2006 -- There are new safety concerns about the controversial prescription drug Accutane. In a study involving almost 14,000, mostly young patients taking the drug, elevations in blood cholesterol, (a blood fat), and a blood liver function test were more common than have been previously reported.