Acne is the most common skin condition in the United States, affecting up to 50 million Americans annually. 1; Acne often causes significant physical and psychological problems such as permanent scarring, poor self-image, depression and anxiety. 2; See your dermatologist for the successful diagnosis and treatment of acne.
Mechanism of action. It is a phosphodiesterase-4 inhibitor, mainly acting on phosphodiesterase 4B (PDE4B), which causes inflammation. Chemically, crisaborole is a phenoxybenzoxaborole. It contains a boron atom that helps penetrate the skin and is essential for its binding activity.
Mechanism Of Action. The exact mechanism of action of NORTHERA in the treatment of neurogenic orthostatic hypotension is unknown. NORTHERA is a synthetic amino acid analog that is directly metabolized to norepinephrine by dopadecarboxylase, which is extensively distributed throughout the body.