These factors include. 1  Living at high latitudes (closer to the polar regions), particularly during winter months. 2  Air quality conditions: high levels of air pollution. 3  Weather conditions: dense cloud covering. 4  The degree to which clothing covers the skin. 5  Use of sunscreen. 6  Skin pigmentation: darker skin types.
A few cases of severe homocysteinemia have been due to rare MTHFR gene mutations (sometimes in combination with a second common MTHFR gene mutation). Symptoms in these patients varied greatly but often involved pronounced neurological symptoms and blood vessel disease.
Furthermore, a MTHFR C677T mutation may cause elevated levels of homocysteine in the body. Homocysteine contributes to oxidative stress and increases risk of heart disease when elevated. MTHFR A1298C MTHFR A1298C mutations affect conversion of methylfolate into BH4, or tetrahydrobiopterin.THFR A1298C mutations may also affect melatonin production, which often leads to sleep disturbances. Additionally, BH4 is important for heart health and deficiency may play a role in the development of cardiovascular disease. MTHFR Treatment The treatment of MTHFR mutations is often a two-pronged approach.