Nucleic acids are linear polymers (chains) of nucleotides. Each nucleotide consists of three components: a purine or pyrimidine nucleobase (sometimes termed nitrogenous base or simply base), a pentose sugar, and a phosphate group. The substructure consisting of a nucleobase plus sugar is termed a nucleoside.
Other studies of Remicade and methotrexate indicate that the two medications together can successfully reduce symptoms of psoriasis and psoriatic arthritis, the researchers report. Studies of Humira and Enbrel in conjunction with methotrexate also revealed the combination to be more effective than the biologic alone.
It remains unclear exactly how methotrexate decreases arthritis activity. 4 - Methotrexate is taken one day a week for arthritis. It is not taken daily like most pills. Methotrexate is available in 2.5 mg tablets. The starting dose for most adults with rheumatoid arthritis is 7.5 to 10 mg (i.e., 3 or 4 pills). The 3 or 4 pills are taken together once a week (i.e., the same day each week). As needed, the dose of methotrexate can be increased to 20 to 25 mg each week.