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The most common causes of lymph node and neck pain are infection of some variety, though swelling and inflammation owing to injury elsewhere may also be to blame. At least in humans, some of the most prominent lymph nodes are located just behind the sinuses and in the soft tissues of the neck and upper throat.
The thymus is a small, two-lobed organ that is located behind the sternum and between the lungs. Itâs part of the immune system. Occasionally lymphoma affects the thymus gland, and this can cause chest pain. Rarely, lymphoma affects lymph nodes located in the lower back. Swelling there may put pressure on the nerves of the spinal cord. However, there are many more likely causes of lower back pain than lymphoma.