These factors include. 1  Living at high latitudes (closer to the polar regions), particularly during winter months. 2  Air quality conditions: high levels of air pollution. 3  Weather conditions: dense cloud covering. 4  The degree to which clothing covers the skin. 5  Use of sunscreen. 6  Skin pigmentation: darker skin types.
A few cases of severe homocysteinemia have been due to rare MTHFR gene mutations (sometimes in combination with a second common MTHFR gene mutation). Symptoms in these patients varied greatly but often involved pronounced neurological symptoms and blood vessel disease.
A GFR rate less than 60 is a warning sign of kidney disease, according to the National Kidney Foundation. Other warning signs include high blood pressure, blood and protein in the urine, a creatinine and Blood Urea Nitrogen (BUN) blood test that falls outside the normal range, more frequent, difficult or painful urination, the swelling of hands and feet and puffiness around the eyes.