According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
This is a list of the longest-reigning monarchs of all time, detailing monarchs and lifelong leaders who reigned for more than 50 years, sorted by length of reign. 1  Currently reigning monarchs are highlighted. 2  Note: the abbreviation (HRE) indicates a sovereign state within the Holy Roman Empire.