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Accutane side effects. Get emergency medical help if you have any of these signs of an allergic reaction to Accutane: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. joint stiffness, bone pain or fracture. cracking or peeling skin, itching, rash, changes in your fingernails or toenails.
Accutane has a relatively long half life and can stay in your body for up to 5 weeks after discontinuation, during which time side effects may continue. A causal link between Accutane and ongoing side effects has not been proven, although much anecdotal evidence exists. When deciding whether to take Accutane patients and their doctors must weigh up the potential side effects against the expected benefit. Read More. Accutane results in long-term remission rather than a permanent cure and a second or third course may be indicated for about 20% of patients.