According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
A Lengthy Dynasty. The imperial house of Japan is the oldest continuous monarchy in the world. Akihito is the 125th emperor in a line that extends back to the countryâs founding in 600 B.C. by the Emperor Jimmu, who legend holds was descended from the sun goddess. Though evidence of the first 25 emperors is shrouded in myth, there is ample historical proof of an unbroken hereditary line from A.D. 500 to today.