According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
The Japanese monarchy is the oldest continuous hereditary monarchy in the world. The imperial house recognizes 125 monarchs beginning with the legendary Emperor Jimmu (traditionally dated to February 11, 660 BC) and continuing up to the current emperor, Akihito; see its family tree.