Glucose is more acidic than simple alcohols with a pK a of about 12 (K a = 10 -12). Compare this to methanol with a pK a of 15.5 (K a = 10 -15.5). The electronegative oxygen atoms in the molecule pull electron density away from the carbon atom bearing the negatively charged oxygen in the conjugate base, stabilizing it.he hydrogen is a little less electronegative than the carbon so a C-H bond is slightly polarized with more electron density on carbon. Excess electron density on a carbon adjacent to a negatively charged oxygen atom (in the alkoxide) destabilizes the conjugate base and makes the acid a little weaker.
Asymptomatic bacteriuria can lead to the development of cystitis or pyelonephritis. All pregnant women should be screened for bacteriuria and subsequently treated with antibiotics such as nitrofurantoin, sulfisoxazole or cephalexin.
Benzocaine topical Pregnancy Warnings. Benzocaine topical has been assigned to pregnancy category C by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancy. Benzocaine topical is only recommended for use during pregnancy when benefit outweighs risk. See references.