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XANTUS is the first international, prospective, observational study to describe the use of rivaroxaban in a broad NVAF patient population. Rates of stroke and major bleeding were low in patients receiving rivaroxaban in routine clinical practice.
Definition of callus. 1  1 : a thickening of or a hard thickened area on skin or bark. 2  2 : a mass of exudate and connective tissue that forms around a break in a bone and is converted into bone in healing. 3  3 : soft tissue that forms over a wounded or cut plant surface.