These factors include. 1  Living at high latitudes (closer to the polar regions), particularly during winter months. 2  Air quality conditions: high levels of air pollution. 3  Weather conditions: dense cloud covering. 4  The degree to which clothing covers the skin. 5  Use of sunscreen. 6  Skin pigmentation: darker skin types.
A few cases of severe homocysteinemia have been due to rare MTHFR gene mutations (sometimes in combination with a second common MTHFR gene mutation). Symptoms in these patients varied greatly but often involved pronounced neurological symptoms and blood vessel disease.
Symptoms of Cricopharyngeal Spasm: 1  Triggering of Foods. 2  High levels of anxiety. 3  Excessive amounts of stress.  Positive and negative 1  emotions. Severe headache.  Weight gain and weight loss.