Acne is the most common skin condition in the United States, affecting up to 50 million Americans annually. 1; Acne often causes significant physical and psychological problems such as permanent scarring, poor self-image, depression and anxiety. 2; See your dermatologist for the successful diagnosis and treatment of acne.
Mechanism of action. It is a phosphodiesterase-4 inhibitor, mainly acting on phosphodiesterase 4B (PDE4B), which causes inflammation. Chemically, crisaborole is a phenoxybenzoxaborole. It contains a boron atom that helps penetrate the skin and is essential for its binding activity.
This is a new class of drugs, of which aliskiren is the only one so far licensed for the treatment of. hypertension. Mechanism of action. Aliskiren was designed as an analogue of the natural substrate of renin: angiotensinogen. Aliskiren. competes with angiotensinogen for access to the active site of the renin enzyme. The drug reduces.