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Place the pan in the microwave oven and cook the meatloaf at medium-high temperature for five minutes. Change the heat setting to high after five minutes and continue cooking for 15 minutes. Remove the meatloaf from the microwave oven after 15 minutes, and cover it with a lid or aluminum foil. After five minutes, use a meat thermometer to check the temperature. You can safely serve meatloaf if it is at least 160 degrees F.
Instructions. Preheat your oven to 325 degrees F. Place the frozen, foil-wrapped meatloaf in a shallow baking pan. Place the baking pan on the preheated oven's center rack. Bake the meatloaf for one hour.Remove the meatloaf from the oven using pot holders. Unwrap the foil, and brush the top of meatloaf with a glaze if desired. Place the meatloaf back into the oven and bake, uncovered, for another 30 to 40 minutes, or until it reaches the proper temperature.Place an instant-read food thermometer into the center of the meatloaf to check it's temperature, which should register 165 degrees F.lace the meatloaf back into the oven and bake, uncovered, for another 30 to 40 minutes, or until it reaches the proper temperature. Place an instant-read food thermometer into the center of the meatloaf to check it's temperature, which should register 165 degrees F.