Going forward, FDA has indicated a willingness to extend that accommodation further upstream in the process. Roughly 72% of the BTD denials relate at least in part to trial design or analysis problems, which suggests that sponsors must do more to engage with FDA prior to submitting their request.
Soave, from the Veneto in North East Italy, has a reputation for producing rather neutral, boring white wines. Its partly deserved. Pop into your local supermarket and buy their cheapest Soave. It will be a commodity wine, with some fresh acidity but rather neutral flavours.
Sordes was a small pterosaur from the late Jurassic (Oxfordian/Kimmeridgian) Karabastau Svita of Kazakhstan. The genus was named in 1971 by Aleksandr Grigorevich Sharov. The type species is Sordes pilosus. The genus name means filth or scum in Latin, a reference to evil spirits in local folklore. The specific name is Latin for hairy; despite sordes being feminine, it has not yet been emended to pilosa.