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Osteogenesis imperfecta (OI) is a group of genetic disorders that mainly affect the bones. The term osteogenesis imperfecta means imperfect bone formation.People with this condition have bones that break easily, often from mild trauma or with no apparent cause.ost cases of osteogenesis imperfecta have an autosomal dominant pattern of inheritance, which means one copy of the altered gene in each cell is sufficient to cause the condition. Many people with type I or type IV osteogenesis imperfecta inherit a mutation from a parent who has the disorder.
In most cases, the osteogenesis imperfecta cause is a dominant genetic defect (known as autosomal dominant) in the genes responsible for making collagen. Some children with osteogenesis imperfecta inherit the disorder from a parent.Other children are born with OI even though there is no family history of the disorder.he Role of Genetics. Because the defect that leads to osteogenesis imperfecta -- whether inherited or due to a spontaneous mutation -- is usually dominant, a person with OI has a 50 percent chance of passing on the disorder to each of his or her children.