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Leflunomide (Arava) is a prescription medication used for treating rheumatoid arthritis and sometimes used for treating psoriatic arthritis. Leflunomide (Arava) is a prescription medication used for treating rheumatoid arthritis and sometimes used for treating psoriatic arthritis.
Thus, an inhibitor of PDE4 results in an increase in cAMP, which is similar to CF101's mechanism of action (discussed below). Otezla(R) was approved for the treatment of psoriatic arthritis in March 2014, and then for the treatment of psoriasis in September 2014. The drug was approved for the treatment of psoriasis based on two Phase 3 clinical trials involving over 1,200 patients.