morphine). Since diffusion across a lipid bilayer requires that a drug be lipid-soluble, the ionized form of a drug cannot cross membranes. Thus, weak acids that are nonprotonated and weak bases that are protonated cannot diffuse across membranes. At a pH that is equal to a drugâs pKa, equal amounts of the protonated and nonprotonated forms are present. Assuming the pH is the same on both sides of a given membrane, the drug will be at equilibrium across the membrane.
Ledyba (Japanese: ã¬ãã£ã Rediba) is a Bug/Flying-type PokÃ©mon introduced in Generation II. Ledyba is a common Bug type PokÃ©mon that resembles a ladybug. It has six legs, that are all wearing gloves.
Litleo is a Fire/Normal type PokÃ©mon introduced in Generation 6. It is known as the Lion Cub PokÃ©mon. Its mane blazes with heat during battle, burning hotter and hotter the stronger its opponent.