According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
Alexandrina Victoria ruled for more than 63 years until her death in 1901 at age 81. Queen Elizabeth, 86 and counting, can still overtake her great-great-grandmother. Until then, however, here's the order of the five longest-reigning U.K. monarchs. Reign:1837 to 1901 (63 years, 7 months, and 3 days).