Precautions and Side Effects. 1  While generally safe and effective when prescribed by a veterinarian, tobramycin can cause side effects in some animals. 2  Tobramycin should not be used in animals with known hypersensitivity or allergy to the drug. Tobramycin and other aminoglycosides can cause loss of hearing (ototoxicity) in animals or loss of balance (vestibulotoxicity). 2  High doses can cause muscle paralysis in animals.
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