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The most common causes of lymph node and neck pain are infection of some variety, though swelling and inflammation owing to injury elsewhere may also be to blame. At least in humans, some of the most prominent lymph nodes are located just behind the sinuses and in the soft tissues of the neck and upper throat.
Inflammatory and immunologic causes of swollen lymph nodes include diseases such as rheumatoid arthritis and lupus, as well as sensitivity to some medications. Many cancers can also cause swelling of lymph nodes. These may be cancers that originate from the lymph nodes or blood cells, such as lymphomas and leukemias.