morphine). Since diffusion across a lipid bilayer requires that a drug be lipid-soluble, the ionized form of a drug cannot cross membranes. Thus, weak acids that are nonprotonated and weak bases that are protonated cannot diffuse across membranes. At a pH that is equal to a drugâs pKa, equal amounts of the protonated and nonprotonated forms are present. Assuming the pH is the same on both sides of a given membrane, the drug will be at equilibrium across the membrane.
Ledyba (Japanese: ã¬ãã£ã Rediba) is a Bug/Flying-type PokÃ©mon introduced in Generation II. Ledyba is a common Bug type PokÃ©mon that resembles a ladybug. It has six legs, that are all wearing gloves.
Ledian (Japanese: ã¬ãã£ã¢ã³ Redian) is a Bug/Flying-type PokÃ©mon introduced in Generation II. Ledian is a moderately large, bipedal creature with a rather large head and six small limbs. It also has star patterns on its back, which grow larger or smaller depending on the number of stars visible in the night sky.