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Accutane side effects. Get emergency medical help if you have any of these signs of an allergic reaction to Accutane: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. joint stiffness, bone pain or fracture. cracking or peeling skin, itching, rash, changes in your fingernails or toenails.
Read More. I did a 6-month course of Accutane several years ago with a different doctor -- in that case, the doctor started me on a low dose to minimize side effects and then eventually took me up to 40 mg. Side effects were tolerable, and my skin remained clear for a few years afterward.