According to the American Psychiatric Association (APA) Practice Guidelines for the Treatment of Patients with Bipolar Disorder, biochemical hypothyroidism develops in 5% to 35% of patients with bipolar disorder, usually within 6 to 18 months of lithium treatment initiation.
The longest-surviving dynasty in the world is the Imperial House of Japan, the Yamato dynasty, whose reign is traditionally dated to 660 BC.
Map: United Kingdom. Queen Elizabeth II will become Britain's longest-reigning monarch on September 9, having been on the throne for 63 years and 216 days. However, Her Majesty's reign is shorter than some other monarchs worldwide. The Queen remains six years behind the world's current longest reigning monarch, Thailand's king Bhumibol Adulyadej.