24 yr old: transected median nerve 48 days ago at wrist level - epineural repair. Tinels sign now positive just a more 24 yr old: transected median nerve 48 days ago at wrist level - epineural repair. Tinels sign now positive just an inch below index finger.
Apoptosis (from Ancient Greek á¼ÏÏÏÏÏÏÎ¹Ï falling off) is a process of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay. Between 50 and 70 billion cells die each day due to apoptosis in the average human adult.
When a death signal is received by the cell, it overrides the brake, and the apoptotic pathway activates proteases and nucleases, enzymes that cut up the protein and DNA of the cell. The main proteases of apoptosis are called caspases; in the nematode, the chief caspase is Ced-3.