A GSM modem can be an external device or a PC Card / PCMCIA Card. Typically, an external GSM modem is connected to a computer through a serial cable or a USB cable. A GSM modem in the form of a PC Card / PCMCIA Card is designed for use with a laptop computer.
Entresto is supplied as a tablet for oral administration. The recommended starting dose of Entresto is 49/51 mg (sacubitril/valsartan) twice-daily. Double the dose of Entresto after 2 to 4 weeks to the target maintenance dose of 97/103 mg (sacubitril/valsartan) twice-daily, as tolerated by the patient.
Mechanism of Action. Entresto is a combination of sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Entresto inhibits neprilysin (neutral endopeptidase; NEP) via LBQ657, the active metabolite of the prodrug sacubitril, and blocks the angiotensin II type-1 (AT1) receptor via valsartan.