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Hedgehog signaling pathway. The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma. The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its
In the 1970s, a gene related to how our brain grows our limbs was given the name âhedgehogâ in relation to the spiky appearance of fruit flies with a defective version of the gene.In 1995, three strains of the âhedgehogâ gene were found and named âDesert-Hedgehogâ, âIndian-Hedgehogâ, and amusingly, âSonic-Hedgehogâ.onic Hedgehog Homolog (SHH) is one of three proteins in the mammalian hedgehog family, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway.