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Cohort Study is an observational study in which a group of individuals â a cohort â are followed over a period of time in order to determine either the incidence rate of certain diseases or the risk factors that lead to those diseases. These studies can be either prospective or retrospective.
A nested case control (NCC) study is a variation of a case-control study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest.