Antibiotics effective against procaryotes which kill or inhibit a wide range of Gram-positive and Gram-negative bacteria are said to be broad spectrum . If effective mainly against Gram-positive or Gram-negative bacteria, they are narrow spectrum.
Sofia: Annual Weather Averages. July is the hottest month in Sofia with an average temperature of 21Â°C (70Â°F) and the coldest is January at -1Â°C (30Â°F) with the most daily sunshine hours at 10 in July. The wettest month is April with an average of 70mm of rain. Average Temperature: Sofia. Loading weather data.
Sofia, Bulgaria, is Europe's most affordable capital for visitors, according to more than one 2013 travel index. But this little-known Balkan city offers plenty of other reasons to visit. Human settlement in Sofia dates to the 5th century B.C., but modern Sofia is a relatively young city by European standards.