Binding of PPARÎ³ to coactivators appears to reduce the levels of coactivators available for binding to pro-inflammatory transcription factors such as NF-ÎºB; this causes a decrease in transcription of a number of pro inflammatory genes, including various interleukins and tumour necrosis factors.
Email. Print. The medial collateral ligament (MCL) is a wide, thick band of tissue that runs down the inner part of the knee from the thighbone (femur) to a point on the shinbone (tibia) about four to six inches from the knee.
Injuries to the MCL commonly occur as a result of a strong force hitting the outside of the knee that causes the MCL â and, possibly, other ligaments on the inside of the knee, such as the anterior cruciate ligament (ACL) â to stretch or tear.1  Show More.ymptoms occur along the inner side of the knee. (The MCL is located on the side of the knee adjacent to the other knee.) Depending on the severity of the injury, pain can range from mild to severe.