Freebase(0.00 / 0 votes)Rate this definition: Japan is an island nation in East Asia. Located in the Pacific Ocean, it lies to the east of the Sea of Japan, China, North Korea, South Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south.
Signs and symptoms of neuroendocrine cancer. A sign is something that can be observed and recognized by a doctor or healthcare professional (for example, a rash). A symptom is something that only the person experiencing it can feel and know (for example, pain or tiredness).
1 Because the pituitary gland affects the other endocrine organs, symptoms and effects of hypopituitarism may be gradual, or sudden and dramatic. 2  The most common pituitary hormone deficiency is growth hormone deficiency. 3  Hypopituitarism is rare in children. Hypopituitarism is also called an underactive pituitary gland. 2  The loss may be partial or total. 3  Because the pituitary gland affects the other endocrine organs, symptoms and effects of hypopituitarism may be gradual, or sudden and dramatic.