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Noun. 1. synergy-the working together of two things (muscles or drugs for example) to produce an effect greater than the sum of their individual effects. synergism.
Definition of SYNERGISM. : interaction of discrete agencies (as industrial firms), agents (as drugs), or conditions such that the total effect is greater than the sum of the individual effects.See synergism defined for kids.ADVERTISEMENT.edical Definition of SYNERGISM. : interaction of discrete agents (as drugs) such that the total effect is greater than the sum of the individual effectsâcalled also synergy; compare antagonism b.