Binding of PPARÎ³ to coactivators appears to reduce the levels of coactivators available for binding to pro-inflammatory transcription factors such as NF-ÎºB; this causes a decrease in transcription of a number of pro inflammatory genes, including various interleukins and tumour necrosis factors.
Email. Print. The medial collateral ligament (MCL) is a wide, thick band of tissue that runs down the inner part of the knee from the thighbone (femur) to a point on the shinbone (tibia) about four to six inches from the knee.
Injuries to the MCL commonly occur as a result of a strong force hitting the outside of the knee that causes the MCL â and, possibly, other ligaments on the inside of the knee, such as the anterior cruciate ligament (ACL) â to stretch or tear.