Owing to melatonin's antioxidant properties, the use of melatonin for the prevention of postoperative pericardial adhesion formation has been investigated. Twelve dogs received pericardial abrasions to promote adhesion and were randomized to receive either melatonin 10 mg/kg plus ethanol 5% in 10 mL sodium chloride or 10 mL sodium chloride dilution with ethanol 5%.
Definition of multifactorial. 1  1 : having characters or a mode of inheritance dependent on a number of genes at different loci. 2  2 or multifactorplay \-Ëfak-tÉr\ : having, involving, or produced by a variety of elements or causes.
A cofactor is a non-protein molecule that carries out chemical reactions that cannot be performed by the standard 20 amino acids. Cofactors can be either inorganic molecules (metals) or small organic molecules (coenzymes).