Could be the cause if: You often feel tired; youâve lost weight for no Â­apparent reason; you are suffering from Â­abdominal pain. Coeliac disease is an adverse Â­reaction to gluten, which is found in wheat, barley and rye and all foods containing them â everything from pasta and bread to pies and some gravies and sauces.
Both genetic and environmental factors are involved in the timing of puberty. Body fat and/or body composition may play a role in regulating the onset of puberty. Puberty is associated with the development of secondary sex characteristics and rapid growth. Central precocious puberty (CPP) is puberty that occurs earlier than normal due to release of hormones from the hypothalamus of the brain.
Mechanisms initiating puberty are unclear. Central influences that regulate release of GnRH include neurotransmitters and peptides (eg, gamma-aminobutyric acid [GABA], kisspeptin). Such factors may inhibit release of GnRH during childhood, then initiate its release to induce puberty in early adolescence.