Freebase(0.00 / 0 votes)Rate this definition: Japan is an island nation in East Asia. Located in the Pacific Ocean, it lies to the east of the Sea of Japan, China, North Korea, South Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south.
Signs and symptoms of neuroendocrine cancer. A sign is something that can be observed and recognized by a doctor or healthcare professional (for example, a rash). A symptom is something that only the person experiencing it can feel and know (for example, pain or tiredness).
1 Macroadenomas are tumors 1 cm across or larger. 2  Macroadenomas can affect a personâs health in 2 ways. 3  First, they can cause symptoms if they make too much of a certain hormone. 4  Second, they can cause symptoms by pressing on normal parts of the pituitary or on nearby nerves, such as the optic nerves.nterior pituitary. Most pituitary tumors begin in the larger, front part of the pituitary gland known as the anterior pituitary. This part of the gland makes several hormones that control other endocrine glands. 1  Growth hormone (GH, also known as somatotropin) promotes body growth during childhood.