Binding of PPARÎ³ to coactivators appears to reduce the levels of coactivators available for binding to pro-inflammatory transcription factors such as NF-ÎºB; this causes a decrease in transcription of a number of pro inflammatory genes, including various interleukins and tumour necrosis factors.
Email. Print. The medial collateral ligament (MCL) is a wide, thick band of tissue that runs down the inner part of the knee from the thighbone (femur) to a point on the shinbone (tibia) about four to six inches from the knee.
Before we further discuss what an LCL (Lateral Collateral Ligament or often times referred to as the Fibular Collateral Ligament) injury is, it important to understand more about the LCL ligament. There are four ligaments located within the knee that connect the lower leg bones to the femur (ACL, MCL, LCL and PCL).