Binding of PPARÎ³ to coactivators appears to reduce the levels of coactivators available for binding to pro-inflammatory transcription factors such as NF-ÎºB; this causes a decrease in transcription of a number of pro inflammatory genes, including various interleukins and tumour necrosis factors.
Email. Print. The medial collateral ligament (MCL) is a wide, thick band of tissue that runs down the inner part of the knee from the thighbone (femur) to a point on the shinbone (tibia) about four to six inches from the knee.
Anatomy. The lateral collateral ligament (LCL) is a one of the four major ligaments in the knee. The LCL is on the outside of the knee connecting the thighbone (femur) to the smaller bone in the lower leg (fibular). Its main function is to avoid varus stress across the knee (where the knee buckles outwards).