Freebase(0.00 / 0 votes)Rate this definition: Japan is an island nation in East Asia. Located in the Pacific Ocean, it lies to the east of the Sea of Japan, China, North Korea, South Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south.
Signs and symptoms of neuroendocrine cancer. A sign is something that can be observed and recognized by a doctor or healthcare professional (for example, a rash). A symptom is something that only the person experiencing it can feel and know (for example, pain or tiredness).
Early-stage ovarian cancer rarely causes any symptoms. Advanced-stage ovarian cancer may cause few and nonspecific symptoms that are often mistaken for more common benign conditions, such as constipation or irritable bowel. Signs and symptoms of ovarian cancer may include: 1  Abdominal bloating or swelling. 2  Quickly feeling full when eating. 3  Weight loss. 4  Discomfort in the pelvis area. 5  Changes in bowel habits, such as constipation. 6  A frequent need to urinate.