Binding of PPARÎ³ to coactivators appears to reduce the levels of coactivators available for binding to pro-inflammatory transcription factors such as NF-ÎºB; this causes a decrease in transcription of a number of pro inflammatory genes, including various interleukins and tumour necrosis factors.
Email. Print. The medial collateral ligament (MCL) is a wide, thick band of tissue that runs down the inner part of the knee from the thighbone (femur) to a point on the shinbone (tibia) about four to six inches from the knee.
As with any other sprain, a MCL injury is the result of excessive stretching or tearing of the ligament. The severity of the injury can range from a slight stretching to a complete rupture of the ligament.earn the Causes of an MCL Tear, plus Prevention and Treatment Strategies. MCL tear, or MCL sprain, is another common knee injury, which typically affects athletes involved in contact sports, such as football, gridiron and soccer. MCL tear and MCL sprain are commonly referred to as a Medial Collateral Ligament Injury.