Antibiotics effective against procaryotes which kill or inhibit a wide range of Gram-positive and Gram-negative bacteria are said to be broad spectrum . If effective mainly against Gram-positive or Gram-negative bacteria, they are narrow spectrum.
Sofia: Annual Weather Averages. July is the hottest month in Sofia with an average temperature of 21Â°C (70Â°F) and the coldest is January at -1Â°C (30Â°F) with the most daily sunshine hours at 10 in July. The wettest month is April with an average of 70mm of rain. Average Temperature: Sofia. Loading weather data.
The SOFIA is a joint program of NASA and the German Aerospace Center (DLR - Deutsches Zentrum fÃ¼r Luft- und Raumfahrt). The program is managed at NASA's Dryden Aircraft Operations Facility in Palmdale, Calif., where the aircraft is based.