Binding of PPARÎ³ to coactivators appears to reduce the levels of coactivators available for binding to pro-inflammatory transcription factors such as NF-ÎºB; this causes a decrease in transcription of a number of pro inflammatory genes, including various interleukins and tumour necrosis factors.
Email. Print. The medial collateral ligament (MCL) is a wide, thick band of tissue that runs down the inner part of the knee from the thighbone (femur) to a point on the shinbone (tibia) about four to six inches from the knee.
Shares & Saves. Save. A medial collateral ligament, or MCL, connects the medial surfaces of the femur (thigh bone) and the tibia (shin bone). The main purpose of the MCL is to resist the forces from the outer surface of the knee to prevent the inner portion from widening under stress.hares & Saves. Save. A medial collateral ligament, or MCL, connects the medial surfaces of the femur (thigh bone) and the tibia (shin bone). The main purpose of the MCL is to resist the forces from the outer surface of the knee to prevent the inner portion from widening under stress.