Introduction. The Renaissance refers to the era in Europe from the 14th to the 16th century in which a new style in painting, sculpture and architecture developed after the Gothic.
Sickle cell disease is caused by a genetic abnormality in the gene for hemoglobin, which results in the production of sickle hemoglobin. When oxygen is released from sickle hemoglobin, it sticks together and forms long rods, which damage and change the shape of the red blood cell.eople who inherit only one sickle hemoglobin gene are carriers (sickle cell trait) and do not have anemia or painful sickle cell crises. They may, though, have a slightly higher incidence of certain conditions such as blood in the urine or urinary tract infections. About 2 million Americans have sickle cell trait.
Genetic Mutation. The gene that can cause Sickle Cell Anemia is called HBB and is located in Chromosome 11. HBB helps in the creation of hemoglobin in the body. A normal adult's hemoglobin consists of two alpha chains and two beta chains; HBB codes for the beta chain and the protein it synthesizes is called beta globin.he trait that causes sickle cell anemia is recessive, which means that the disorder will only occur in a person who is homozygous recessive for the sickle cell trait. One way for this to occur is for a person to be an offspring of two parents who are heterozygous for the sickle cell trait.