High PTH levels may be caused by: 1  A parathyroid gland growth (hyperplasia) or a parathyroid tumor. 2  A low level of calcium in the blood. 3  Some types of cancer, such as of the lung, kidney, pancreatic, or ovarian cancer.
MTOR inhibitors What are MTOR inhibitors. Mammalian target of rapamycin (mTOR) inhibitors block the activity of the mammalian target of rapamycin. Mammalian target of rapamycin is a protein kinase, which regulates growth factors that stimulate cell growth and angiogenesis. In certain cancers the mTOR pathway is more active. Mammalian target of rapamycin (mTOR) inhibitors are used in treatment of renal cancer and is being studied for use in other types of cancers.
The mechanistic target of rapamycin, also known as mammalian target of rapamycin (mTOR) or FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a protein that in humans is encoded by the MTOR gene.iscovery [edit]. MTOR was first named as the mammalian target of rapamycin. Rapamycin was discovered in a soil sample from Easter Island, known locally as Rapa Nui, in the 1970s.