Freebase(0.00 / 0 votes)Rate this definition: Japan is an island nation in East Asia. Located in the Pacific Ocean, it lies to the east of the Sea of Japan, China, North Korea, South Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south.
Signs and symptoms of neuroendocrine cancer. A sign is something that can be observed and recognized by a doctor or healthcare professional (for example, a rash). A symptom is something that only the person experiencing it can feel and know (for example, pain or tiredness).
The list of possible symptoms is long. Symptoms of tumor mass pressure can include headaches and trouble seeing. Symptoms of low pituitary hormones include fatigue, dizziness, dry skin, irregular periods in women, and sexual dysfunction in men. Other symptoms depend on the hormone that is affected. ACTH-producing tumors can cause Cushing's disease.