Binding of PPARÎ³ to coactivators appears to reduce the levels of coactivators available for binding to pro-inflammatory transcription factors such as NF-ÎºB; this causes a decrease in transcription of a number of pro inflammatory genes, including various interleukins and tumour necrosis factors.
Email. Print. The medial collateral ligament (MCL) is a wide, thick band of tissue that runs down the inner part of the knee from the thighbone (femur) to a point on the shinbone (tibia) about four to six inches from the knee.
The lateral collateral ligament (LCL) is the ligament located in the knee joint. Ligaments are thick, strong bands of tissue that connect bone to bone.The LCL runs along the outside of the knee joint, from the outside of the bottom of the thighbone (femur) to the top of the lower-leg bone (fibula).he lateral collateral ligament (LCL) is the ligament located in the knee joint. Ligaments are thick, strong bands of tissue that connect bone to bone.