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The list of signs and symptoms mentioned in various sources for Hemoglobin SC includes the 15 symptoms listed below: 1  Proliferative retinopathy. 2  Sudden weakness. 3  Severe joint pain.  Pain in 1  extremities. Abdominal cramps. 2  Fever. Spontaneous blood in the 3  urine. Nosebleed.  Neurological 1  manifestations. 2  Headache. Drowsiness.
In most individuals with beta-globin type methemoglobinemia, the only symptom is cyanosis, which is a bluish appearance of the skin, mucous membranes, or the area underneath the fingernails due to a lack of oxygen in the blood.Symptoms may appear as early as age 3 to 4 months.utations in the HBB gene cause methemoglobinemia, beta-globin type. Hemoglobin consists of four protein subunits and four iron-containing molecules called heme. Heme molecules are necessary for red blood cells to pick up oxygen in the lungs and release oxygen to other cells in the body.