What is the definition of a dominant trait in biology? What is the difference between biology and AP biology? What is the difference between molecular biology and cell biology?
DNA gyrase, often referred to simply as gyrase, is an enzyme that relieves strain while double-strand DNA is being unwound by helicase. It is also known as DNA topoisomerase II. This causes negative supercoiling of the DNA. Bacterial DNA gyrase is the target of many antibiotics, including nalidixic acid, novobiocin, and ciprofloxacin.
If this is the case, then positive DNA supercoils should be the preferred relaxation substrate for topoisomerase IIÎ±, the enzyme isoform involved in replicative processes in humans. Results indicate that human topoisomerase IIÎ± relaxes positively supercoiled plasmids >10-fold faster than negatively supercoiled molecules.