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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Degenerative Disc Disease. About Degenerative Disc Disease. Degeneration of the discs particularly in the moving sections of the spine (cervical and lumbar levels) is a natural process of aging. This dehydration or desiccation of the disc material reduces the flexibility and typically the height of the disc.