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Causes. Ischemic cardiomyopathy is weakness in the muscle of the heart due to coronary artery disease. Individuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.ndividuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.
Symptoms of Ischemic Cardiomyopathy. You can have early-stage heart disease with no symptoms. As the arteries narrow further and blood flow becomes impaired, you may experience a variety of symptoms, including: 1  shortness of breath. 2  extreme fatigue. 3  dizziness, lightheadedness, or fainting. 4  chest pain and pressure (angina). 5  heart palpitations. 6  weight gain.