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In terms of cause and effect, a root cause is the cause of symptoms and a symptom stemming from a root cause is the effect of the root cause. There is no entity disease involved in cause and effect.
In humans, diseases can be caused by the growth of microorganisms such as bacteria, viruses, and protozoa. Bacterial growth, however, is not mandatory to cause disease. For example, some bacterial pathogens cause disease by virtue of a toxic component of the bacterial cell such as lipopolysaccharide.