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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Degenerative Disc Disease (Definition) 1  Degenerative disks are when the normal spongy architechture of the disks goes away. 2  Spinal stenosis is medical condition in which openings where nerves leave the spine are narrowed. 3  A stricture is an anatomic narrowing of any structure in the body with a lumen.