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In the alveoli Alveolus (also called air sac) is the capillary-rich sac in the lungs where the exchange of oxygen and carbon dioxide takes place by diffusion.
2. Gas exchange between the alveoli and pulmonary capillaries. A continuous exchange of oxygen and carbon dioxide occurs between the alveoli and pulmonary capillaries, changing the partial pressures of both gases. Oxygen diffuses out of the alveoli into the pulmonary capillaries and carbon dioxide diffuses from the pulmonary capillaries into the alveoli.