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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Degenerative Disc Disease (Definition) Degenerative disks are when the normal spongy architechture of the disks goes away. The disks normally are between the vertebre in your spine. So when the disks degenerate, you lose mobility and eventually the bones can touch together, which is very painful.