When incompatible blood is given, antibodies and complement in the recipient plasma attack the antigens on the donor RBC. Hemolysis ensues The antigen-antibody complex activate the Hageman factor (factor XII), which acts on the kinin system to produce bradykinin
Three years. The month and year of expiration is reflected on the individual packets and the outside of the box directly under the âDrug Factsâ section. Due to the high demand, all of our saline has been purchased long before it approaches expiration. more.
Once the original container is opened, either by the patient or the health care provider who will dispense the drug, that original expiration date on the container can no longer be relied upon.2 However, the actual shelf life of the drug may be much longer, as stability studies have shown.3.