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Sudafed (pseudoephedrine) and other decongestants can cause erectile dysfunction (ED) in some men. If you are having trouble getting or maintaining an erection while taking Sudafed, your doctor or pharmacist can recommend a different medication.
1 Changes in blood sugar can occur in people with diabetes taking diuretics or beta-blockers for high blood pressure.  If you have problems with erections during sex, talk with your doctor. Some high blood pressure medications can cause this problem. Reducing the dose or changing to another type of medication may help. But high blood pressure itself can also cause erectile dysfunction.