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Causes. Ischemic cardiomyopathy is weakness in the muscle of the heart due to coronary artery disease. Individuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.ndividuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.
Cardiomyopathy is diseased heart muscle that cannot function (contract) adequately. Cardiomyopathy results in the failure of the heart muscle to meet the needs of the body for oxygen rich blood and removal of carbon dioxide and other waste products. There are many causes of cardiomyopathy, but the end result is a heart that is weak and cannot maintain a normal ejection fraction or cardiac output. The heart is an electrically-innervated, muscular pump that pushes blood throughout the body through blood vessels.