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The weakness that characterizes hemiplegic migraine is a manifestation of motor aura. The aura of hemiplegic migraine is most probably caused by cortical spreading depression, a self-propagating wave of neuronal and glial depolarization that spreads across the cerebral cortex.
People with hemiplegic migraines experience paralysis or weakness on one side of the body, disturbances in speech and vision, and other symptoms that often mimic a stroke. The paralysis is usually temporary, but it can last for several days. Two types of hemiplegic migraine exist: