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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
verb (used without object), degenerated, degenerating. 1. to fall below a normal or desirable level in physical, mental, or moral qualities; deteriorate: The morale of the soldiers degenerated, and they were unable to fight. 2. to diminish in quality, especially from a former state of coherence, balance, integrity, etc.: The debate degenerated into an exchange of insults.