When incompatible blood is given, antibodies and complement in the recipient plasma attack the antigens on the donor RBC. Hemolysis ensues The antigen-antibody complex activate the Hageman factor (factor XII), which acts on the kinin system to produce bradykinin
Still it is not advisable to take it after the expiry date written on the bottle. This is just for your information to let you know that you are safe. Anyway Saline Nasal spray is not going to do any harm even if you used an expired one. So forget about it.
Once opened the unused portion of the solution may be stored in the original container for up to 75 days until used. Calculate 75 days from when the original container was opened and record this date on the bottle. Verify that the expiration date on the original container is longer than 75 days.