In both sleep laboratory and outpatient studies, elderly patients with insomnia responded to a 5 mg dose with a reduced sleep latency, and thus 5 mg is the recommended dose in this population. During short-term treatment (14 night studies) of elderly patients with Sonata, no adverse event with a frequency of at least 1% occurred at a significantly higher rate with either 5 mg or 10 mg Sonata than with placebo.
As in all other cells, the resting potential of a pacemaker cell (-60mV to -70mV) is caused by a continuous outflow or leak of potassium ions through ion channel proteins in the membrane that surrounds the cells.hese cells form the atrioventricular node (or AV node), which is an area between the left atrium and the right ventricle within the atrial septum, will take over the pacemaker responsibility. The cells of the AV node normally discharge at about 40-60 beats per minute, and are called the secondary pacemaker.
Pacemakers do not take over the work of the heart. After you have a pacemaker, your heart still does all its own work. Rather, the pacemaker merely helps to regulate the timing and sequence of of your heart beat. Pacemakers consist of two major parts: the generator and the leads.