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During prophase, the nucleus disappears, spindle fibers form, and DNA condenses into chromosomes (sister chromatids). During metaphase, the sister chromatids align along the equator of the cell by attaching their centromeres to the spindle fibers. During anaphase, sister chromatids are separated at the centromere and are pulled towards opposite poles of the cell by the mitotic spindle. During telophase, chromosomes arrive at opposite poles and unwind into thin strands of DNA, the spindle fibers disappear, and the nuclear membrane reappears.
spindle fibers A collection of microtubules attached to a centromere during mitosis and meiosis that are responsible for the movement of the chromosomes to opposite poles. Spindle fibers align the chromosomes along the middle of the cell nucleus.ome attach to one kinetochore of a dyad with those growing from the opposite centrosome binding to the other kinetochore of that dyad. Some bind to the arms of the chromosomes. Spindle fibers are made of microtubules. Microtubules are lengthened and shortened by the addition and loss of tubulin subunits.