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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Definition of degenerate. 1  intransitive verb. 2  1 : to pass from a higher to a lower type or condition : deteriorate her fixed mysterious smile degenerated into a fatuous stare â J. C. Powys. 3  2 : to sink into a low intellectual or moral state The debate degenerated into a shouting match.