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Causes. Ischemic cardiomyopathy is weakness in the muscle of the heart due to coronary artery disease. Individuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.ndividuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.
Ischemia is a symptom in which a person does not have enough blood supply to a part of the body, making that part of the body ischemic. For example, in a heart attack, a coronary artery is blocked so blood cannot get to the heart muscle beyond the blockage point. The heart muscle lacking blood supply has ischemia.