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About the time of birth in mammals, a secondary ossification center appears in each end (epiphysis) of long bones. Periosteal buds carry mesenchyme and blood vessels in and the process is similar to that occurring in a primary ossification center.
The process by which bone is formed is termed osteogenesis or ossification. Bone is never formed as a primary tissue: it always replaces a preexisting support tissue. There are two types of bone formation: intramembranous and endochondral ossification.