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Benadryl is originally designed for humans and too much could be harmful to your dog. Therefore, it's also important to make sure you have the correct dosage for your dog's weight. Generally, the recommended dosage of Benadryl is 1mg per 1lb of your dog's weight. It should only be given to your dog every 8 hours.
An over the counter antihistamine like Benadryl usually takes down the swelling within 20 minutes or so. The liquid usually comes in a dose of 12.5mg per teaspoon - pills are usually 25mg each. Pets will need 1mg for each pound they weigh. This equals 3/4 teaspoon of liquid or 1.2 pill for a 10lb cat or dog.