A mutation is a permanent change in the DNA sequence of a gene. Mutations in a gene's DNA sequence can alter the amino acid sequence of the protein encoded by the gene.
Connectivity Map. This research effort aims to generate a detailed map that links gene patterns associated with disease to corresponding patterns produced by drug candidates and a variety of genetic manipulations.The Connectivity Map is the most comprehensive effort yet for using genomics in a drug-discovery framework.his research effort aims to generate a detailed map that links gene patterns associated with disease to corresponding patterns produced by drug candidates and a variety of genetic manipulations.
Modes of Brain Connectivity. When applied to the brain, the term connectivity refers to several different and interrelated aspects of brain organization (Horwitz, 2003). A fundamental distinction is that between structural connectivity, functional connectivity and effective connectivity (Friston, 1994).