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Signs of physical and emotional exhaustion: 1  Chronic fatigue. 2  Insomnia. 3  Forgetfulness/impaired concentration and attention. 4  Physical symptoms. 5  Increased illness. 6  Loss of appetite. 7  Anxiety. 8  Depression. 9  Anger.
Symptoms of POTS and MS. The most common symptom in our study population was fatigue. Fatigue is a characteristic finding in MS, usually described as physical exhaustion that is unrelated to the amount of activity performed. Many patients complain of feeling exhausted on waking, even if they have slept soundly.