In 1841 and 1842, the first two years of the Trail's use by emigrant parties, the overland route ended at Fort Walla Walla, at the mouth of the Walla Walla River. From there, emigrants rafted their wagons down the Columbia River to the Willamette River Valley.
I have been an insulin dependent diabetic for 20 years. I had my first ever cortison injection for a worn out knee. For 5 days after the injection my blood sugar levels ran between 450 and 600. No matter how much fast acting insulin I took, it would not go down.
If you weigh 140 pounds and have type 1 diabetes, 1 gram of glucose will raise your blood sugar about 5 mg/dl no matter what your blood sugar may be, because you cannot produce any insulin to offset the glucose. If you weigh twice that, or 280 pounds, 1 gram will raise your blood sugar only half as much. A 70-pound diabetic child, on the other hand, will experience double the blood sugar increase, or 10 mg/dl per gram of glucose consumed. Thus, the effect of ingested glucose on blood sugar is inversely related to your weight.