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It is believed that itching may worsen at night due to the various changes in the circadian rhythm. The circadian rhythm is the bodyâs âinternal clockâ of sorts where different biological processes seem to correlate with a 24 hour period on a daily basis.
There are two different types of antihistamine â the older group, sedating antihistamines, can enter the brain and cause drowsiness, while the newer non-sedating antihistamines do not. Itching can occur during the day but is usually worse in early evening and at night, so sedating antihistamines are used because they help make you sleepy, as well as reducing the itch.