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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
British English: degenerate VERB. If you say that someone or something degenerates, you mean that they become worse in some way, for example weaker, lower in quality, or more dangerous.Inactivity can make your joints stiff, and the bones may begin to degenerate.