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It is believed that itching may worsen at night due to the various changes in the circadian rhythm. The circadian rhythm is the bodyâs âinternal clockâ of sorts where different biological processes seem to correlate with a 24 hour period on a daily basis.
'It is not clear why shingles pain gets worse at night, but it could be to do with levels of neurotransmitters, chemicals that transmit signals from a neuron to target cells, and hormones involved in pain perception, rising at night,' says John Oxford, a professor of virology at Queen Mary College University of London.