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The mononuclear phagocyte system constitutes macrophage cells spread throughout the human body. The macrophages are long-lived cells that provide a major defense system against hostile elements through phagocytosis and subsequent intracellular destruction of the particle or cell.
Monocytes are a type of white blood cell which circulate in the blood. The CAE virus cannot replicate inside a monocyte but its genome (called a provirus) is carried to all tissues of the body without being detected by the immune system.When a monocyte migrates to body tissues it matures into a macrophage.he CAE virus will know that it is near a monocyte or macrophage because the envelope protein on the surface of the virus will fit only with a cell surface protein that exists only on goat (and sheep) monocyte/ macrophage cells.