In 1841 and 1842, the first two years of the Trail's use by emigrant parties, the overland route ended at Fort Walla Walla, at the mouth of the Walla Walla River. From there, emigrants rafted their wagons down the Columbia River to the Willamette River Valley.
I have been an insulin dependent diabetic for 20 years. I had my first ever cortison injection for a worn out knee. For 5 days after the injection my blood sugar levels ran between 450 and 600. No matter how much fast acting insulin I took, it would not go down.
Cortisol also helps normalize blood sugar levels. When the pressure is on, your cortisol levels can run high. Over time, continuously high cortisol levels lead to high blood pressure, weight gain, insomnia, irritable bowel syndrome (IBS), low sex drive and anxiety; it is also a contributing factor to heart disease.