A mutation is a permanent change in the DNA sequence of a gene. Mutations in a gene's DNA sequence can alter the amino acid sequence of the protein encoded by the gene.
Connectivity Map. This research effort aims to generate a detailed map that links gene patterns associated with disease to corresponding patterns produced by drug candidates and a variety of genetic manipulations.The Connectivity Map is the most comprehensive effort yet for using genomics in a drug-discovery framework.his research effort aims to generate a detailed map that links gene patterns associated with disease to corresponding patterns produced by drug candidates and a variety of genetic manipulations.
Linkage and Gene Mapping. Photo by: Johan Swanepoel. Linkage refers to the presence of two different genes on the same chromosome. Two genes that occur on the same chromosome are said to be linked, and those that occur very close together are tightly linked. Study of linkage provides information about the relative position of genes on chromosomes, allowing the construction of chromosome maps.