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Itching hands and feet may be caused by a reaction to something in the diet or may be due to a more serious condition, such as diabetes. Vitamin toxicity may also cause itching skin in some people.
Blisters on hands and feet can be due to dyshidrotic eczema, a skin condition, initially appearing as small itchy clusters of clear water (fluid-filled) vesicles. Usually this condition involves center of the palms and also sides of the fingers; but occasionally the soles of the feet may also get affected.