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In addition to fatigue, people who are vitamin B-12-deficient can experience a wide range of symptoms. They may have dizziness, headache, shortness of breath, cold extremities, skin discoloration and/or chest pain. Vitamin B-12 deficiency can also lead to weakened bones and difficulty maintaining balance. Confusion, dementia, depression and impacted memory may also occur.
Among other affects, the group of B Vitamins is involved in regulating the body's level of tryptophan, an amino acid important for maintaining healthy sleep (covered later). 1  Vitamin B3 (niacin) often promotes sleep in people who have insomnia caused by depression and increases effectiveness of tryptophan. It is reported to help people who fall asleep rapidly but keep waking up during the night. Vitamin B5 (pantothenic acid) is good for relieving stress and anxiety. A deficiency of B5 can cause sleep disturbances and fatigue. Vitamin B9 (folic acid) deficiency has been linked to insomnia.