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Let's say you have a three foot wide safe that weighs 1,000 pounds, and your floor joists span 12 feet (which is typical). This three foot by 12 foot section of the floor was designed to safely carry a live load of 3 x 12 x 40 PSF, which equals 1,440 pounds.
Douglas fir 2-by-10 joists graded as Structural Select allows joist spans up to 21 feet for a live load of 30 pounds per square foot when spaced 12 inches apart, 19 feet 1 inch for 16 inch spacing and 16 feet 8 inches for 24 inch spacing. A live load of 60 pounds per square foot demands more support and shorter spans.