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Classic mono usually begins with 2 to 5 days of feeling tired and under the weather, sometimes with a fever. This may even last a week or two. Then a sore throat develops with swollen glands in the neck and elsewhere. Fever and tiredness increase.
Mono affects about 45 out of 100,000 people, mostly teens and young adults. It usually isn't a serious disease. But it can cause fatigue and weakness that interfere with daily life.