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During prophase, the nucleus disappears, spindle fibers form, and DNA condenses into chromosomes (sister chromatids). During metaphase, the sister chromatids align along the equator of the cell by attaching their centromeres to the spindle fibers. During anaphase, sister chromatids are separated at the centromere and are pulled towards opposite poles of the cell by the mitotic spindle. During telophase, chromosomes arrive at opposite poles and unwind into thin strands of DNA, the spindle fibers disappear, and the nuclear membrane reappears.
spindle fibers A collection of microtubules attached to a centromere during mitosis and meiosis that are responsible for the movement of the chromosomes to opposite poles. Spindle fibers align the chromosomes along the middle of the cell nucleus. The protein fibers formed during prophase of nuclear division; chromosomes attach to these fibers at the centromere. spindle The aggregation of microtubules that is involved in the movement and separation of chromosomes during mitosis and meiosis.