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In terms of cause and effect, a root cause is the cause of symptoms and a symptom stemming from a root cause is the effect of the root cause. There is no entity disease involved in cause and effect.
A disease is a particular abnormal condition, a disorder of a structure or function, that affects part or all of an organism. The study of disease is called pathology which includes the study of cause. Disease is often construed as a medical condition associated with specific symptoms and signs. It may be caused by external factors such as pathogens, or it may be caused by internal dysfunctions particularly of the immune system such as an immunodeficiency, or a hypersensitivity including allergies and autoimmunity.