When incompatible blood is given, antibodies and complement in the recipient plasma attack the antigens on the donor RBC. Hemolysis ensues The antigen-antibody complex activate the Hageman factor (factor XII), which acts on the kinin system to produce bradykinin
Still it is not advisable to take it after the expiry date written on the bottle. This is just for your information to let you know that you are safe. Anyway Saline Nasal spray is not going to do any harm even if you used an expired one. So forget about it.
Expired Medications â Are They Safe? What does that expiration date on the medication bottle mean, anyway? The Medical Letter, a well-respected publication, addressed this topic in 2002, then again in 2009. In reading those two reports, it seems the answer to the question is, it depends.