When incompatible blood is given, antibodies and complement in the recipient plasma attack the antigens on the donor RBC. Hemolysis ensues The antigen-antibody complex activate the Hageman factor (factor XII), which acts on the kinin system to produce bradykinin
Still it is not advisable to take it after the expiry date written on the bottle. This is just for your information to let you know that you are safe. Anyway Saline Nasal spray is not going to do any harm even if you used an expired one. So forget about it.
While you shouldn't use a discolored EpiPen, an expired injection may be better than nothing, he said Actually, most EpiPens that are expired won't have that discoloration. And so you should really just rely upon the expiration date. FOX25 found a recent Consumer Reports study that tested 35-injectors two years past their expiration date.