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Sudafed (pseudoephedrine) and other decongestants can cause erectile dysfunction (ED) in some men. If you are having trouble getting or maintaining an erection while taking Sudafed, your doctor or pharmacist can recommend a different medication.
For this reason, pseudoephedrine is sometimes used for excessive daytime sleepiness, work-shift disorder, and narcolepsy (the inability of the brain to control the sleep-wake cycle). More studies are needed to demonstrate how the stimulant and wakefulness actions of pseudoephedrine affect the quality of sleep.