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Causes. Ischemic cardiomyopathy is weakness in the muscle of the heart due to coronary artery disease. Individuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.ndividuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.
Ischemia is the medical term for what happens when your heart muscle doesn't get enough oxygen. Ischemia usually happens because of a shortage of blood and oxygen to the heart muscle. It is usually caused by a narrowing or blockage of one or more of the coronary arteries (which supply blood to the heart muscle). In many cases ischemia is a temporary problem.