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Note: This page contains information about the side effects of clozapine. Some of the dosage forms included on this document may not apply to the brand name Clozaril. In Summary. Common side effects of Clozaril include: hypotension, fever, tachycardia, nausea, vomiting, dizziness, headache, sedation, constipation, and weight gain. Other side effects include: syncope, and diaphoresis. See below for a comprehensive list of adverse effects. For the Consumer.
Second-generation treatment gives patients a greater risk for disruptive metabolic side effects. The drugs can produce severe weight gain often accompanied by type 2 diabetes mellitus and hypercholesterolemia. In addition, clozapine has the potential to cause toxic side effects. Researchers have made connections between the antipsychotic drugs and agranulocytosis, a dangerous reduction in the number of white blood cells3. These consequences lead to the continued research in psychopharmacological treatment of schizophrenia.