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Classic mono usually begins with 2 to 5 days of feeling tired and under the weather, sometimes with a fever. This may even last a week or two. Then a sore throat develops with swollen glands in the neck and elsewhere. Fever and tiredness increase.
77 Followers. A. Yes, you can, but very few people do. Mononucleosis is usually caused by the Epstein-Barr virus (EBV). Symptoms usually include fever, swollen and painful tonsils, and enlarged lymph nodes. Fatigue and low energy can last for weeks or months.nfection by EBV generally results in lifelong immunityâyou can only have EBV mono once. Thereâs also a less common form of mononucleosis, caused by infection by cytomegalovirus (CMV). In one study of people with mono, about one out of seven had mono caused by CMV; the rest had typical EBV mononucleosis.