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The mononuclear phagocyte system constitutes macrophage cells spread throughout the human body. The macrophages are long-lived cells that provide a major defense system against hostile elements through phagocytosis and subsequent intracellular destruction of the particle or cell.
Langerhans cells are monocytes within the epidermis that recognise and process small molecules penetrating the skin surface. These antigen-presenting cells are identified in tissue sections by characteristic surface markers. Pigment cells in the basal layer (melanocytes) protect the skin from ultraviolet radiation.