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Causes. Ischemic cardiomyopathy is weakness in the muscle of the heart due to coronary artery disease. Individuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.ndividuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.
Ischemic heart disease is also known as coronary artery disease or hardening of the arteries.. Cholesterol plaque can build up in the arteries of the heart and cause ischemia, which means the heart is not getting enough blood flow and oxygen. If the plaque blocks an artery, a heart attack can result.