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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Hypertrophic degenerative changes refers to enlargement of a  particular organ or structure due to degeneration of that part. An  example of this is in the musculoskeletal s â¦ ystem, where margins of  joints form osteophyte, or large outgrowths of bone at the margins  of joints.