If you smoke on the higher end of the temperature range subtract about 10 minutes per pound. This means a ten-pound pork shoulder can take 15 hours to finish. Many people find it difficult to maintain a good temperature for this long and choose to wrap the pork in foil and place it in the oven.
Non-tropic hormones behave in an opposite manner to tropic hormones. They act on target cells rather than on the endocrine glands. Non-tropic hormones are those that act directly on targeted tissues or cells, and not on other endocrine gland to stimulate release of other hormones. 1  Many hormones act in a chain reaction. Tropic hormones usually act in the beginning of the reaction stimulating other endocrine gland to eventually release non-tropic hormones. These are the ones that act in the end of the chain reaction on other cells that are not part of other endocrine gland.
1 Estrogen refers to a family of hormones, including estrone, estradiol and estriol which are primarily responsible for female reproductive processes and secondary sexual characteristics in mammals. 2  Estrogen is produced by the ovaries and in smaller amounts by the adrenal cortex, testes and fetoplacental unit.