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Benadryl is originally designed for humans and too much could be harmful to your dog. Therefore, it's also important to make sure you have the correct dosage for your dog's weight. Generally, the recommended dosage of Benadryl is 1mg per 1lb of your dog's weight. It should only be given to your dog every 8 hours.
Vets recommend Benadryl for dogs on a fairly regular basis, so the very broad answer to this question is, yes â in SOME situations, Benadryl is safe to give to dogs. There are, though, a lot of things you need to check carefully before you go ahead and administer this drug to your pet.