When incompatible blood is given, antibodies and complement in the recipient plasma attack the antigens on the donor RBC. Hemolysis ensues The antigen-antibody complex activate the Hageman factor (factor XII), which acts on the kinin system to produce bradykinin
Three years. The month and year of expiration is reflected on the individual packets and the outside of the box directly under the âDrug Factsâ section. Due to the high demand, all of our saline has been purchased long before it approaches expiration. more.
âMany drugs stored under reasonable conditions in their original unopened containers retain 90 percent of their potency for at least 5 years after the expiration date on the label, and sometimes much longer,â The Medical Letter report concludes, with one important caveat: âEpinephrine in EpiPen is an important exceptionâ as these products gradually lose potency once the expiration date passes.