When incompatible blood is given, antibodies and complement in the recipient plasma attack the antigens on the donor RBC. Hemolysis ensues The antigen-antibody complex activate the Hageman factor (factor XII), which acts on the kinin system to produce bradykinin
Still it is not advisable to take it after the expiry date written on the bottle. This is just for your information to let you know that you are safe. Anyway Saline Nasal spray is not going to do any harm even if you used an expired one. So forget about it.
Quote from lpnandloveit1 I have always been told that the manufacturers exp date was for sealed unopened vials. Jun 9, '05. All multi-dose vials are marked when opened, usually insulin and such have a 30 day expiration date from date opened, but they never lasted that long on any unit I worked. If there is a change in color, nature, or if nurse feels vial was unsafe they were tossed.