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Overview. 1  Quinine, a bitter tasting powder made from the bark of the cinchona tree, is known mainly for its use in malaria treatment. 2  Tonic water, a bitter liquid sometimes used as a mix for alcoholic drinks, contains only a small amount of quinine compared to quinine medications.
Quinine has been widely studied as an antimalarial, and has been used at doses of 325 mg to 1 g as the sulfate salt. Classical doses of the crude bark were approximately 1 g.