From this knowledge management definition we can see that it depends upon the management of the organization's knowledge creation and conversion mechanisms; organizational memory and retrieval facilities; organizational learning; and organizational culture.
A leaky mitral valve, or mitral regurgitation, can develop when the valve flaps (called leaflets) do not close effectively. This can happen either because the valve flaps are scarred or defective, or because the heart has become enlarged, stretching the valve opening so much that the flaps no longer meet in the center.
Acute mitral valve regurgitation occurs when the mitral valve or one of its supporting structures ruptures suddenly, creating an immediate overload of blood volume and pressure in the left side of the heart. Your heart doesn't have time to adjust to the increased volume and pressure of blood (as it does in chronic MR).