Before determining if a data point is an outlier, the normal data point value range must be determined. To do so, a random sample of a population must be taken, and the data points must be ordered from smallest to largest.
The currently recommended dose of naloxone is 0.1 mg/kg for infants and children from birth to 5 years of age or 20 kg of body weight. Children olden than 5 years of age or weighing more than 20 kg may be given 2.0 mg.
In one small study, volunteers who received 24 mg/70 kg did not demonstrate toxicity. In another study, 36 patients with acute stroke received a loading dose of 4 mg/kg (10 mg/m2/min) of naloxone hydrochloride injection followed immediately by 2 mg/kg/hr for 24 hours.