Profound sedation, respiratory depression, coma, and death may result from the concomitant use of Buprenex with benzodiazepines or other CNS depressants (e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, other opioids, alcohol).
The MOU is developed through a process of negotiation and mutual assent, finalized through acceptance of the MOU instrument, and approved by the appropriate agency representatives who signify such approval by signing the MOU.
Essentially, TRu is an expression of contentment, satisfaction, goodness, approval, and/or of course, agreement. It is generally enunciated in a deep, low voice, with a slightly increasing pitch, and the vowel sound of u is elongated without the diphthong. TRu can also be used to fill a void in conversation.