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Rating Newest Oldest. Best Answer: Denaturation is a process in which proteins or nucleic acids lose their structure by application of some external stress or compound. If proteins in a living cell are denatured, this results in disruption of cell activity and possibly cell death. Source(s): http://en.wikipedia.org/wiki/Denaturatio...
Wiktionary (5.00 / 1 vote) Rate this definition: denotation (Noun) The act of denoting, or something (such as a symbol) that denotes. denotation (Noun) The primary, literal, or explicit meaning of a word, phrase, or symbol; that which a word denotes, as contrasted with its connotation; the aggregate or set of objects of which a word may be predicated.