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1 Urobilinogen in urine can be a sign of liver disease (cirrhosis, hepatitis) or that the flow of bile from the gallbladder is blocked. 2  Bence Jones protein. 3  This is an abnormal protein found in the urine of about 50% of people with a rare type of cancer called multiple myeloma. Other substances that may be checked during a urine test include: 2  Bilirubin. 3  This is a substance formed by the breakdown of red blood cells. 4  It is passed from the body in stool. 5  Bilirubin is not found in urine.
Bile (mainly conjugated bilirubin) is converted to urobilinogen by intestinal bacteria. Most of the urobilinogen is excreted in faeces or reabsorbed and transported back to the liver to be reconverted into bile. The remaining urobilinogen (about 1% of total) is excreted in the urine. 1  The amount of conjugated bilirubin present in serum in healthy subjects is small (less than 10% of total bilirubin). An elevated level of conjugated serum bilirubin implies liver disease. Therefore, because only conjugated bilirubin appears in urine, bilirubinuria also implies liver disease.