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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
A low white blood cell count may also indicate the presence of a serious bacterial, viral, or fungal infection that attacks the immune system, such as the human immunodeficiency virus . Some congenital disorders, including lupus and myelofibrosis, cause the body to attack its own defense system, depleting bone marrow and white blood cells.