The implicit meaning is that someone who will never have the requirement, access or necessity for something, will never know its value. These sayings are used in a disparaging way; pigs and monkeys both are implied to be inferior to those that appreciate pearls and ginger, respectively. This is laughable human hubris.
Aplastic anemia is a rare disease in which the bone marrow and the hematopoietic stem cells that reside there are damaged. This causes a deficiency of all three blood cell types (pancytopenia): red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). Aplastic refers to inability of the stem cells to generate mature blood cells. It is most prevalent in people in their teens and twenties, but is also common among the elderly. It can be caused by exposure to chemicals, drugs, radiation, immune disease, and heredity. However, in about half the cases, the cause is unknown. The definitive diagnosis is by bone marrow biopsy; normal bone marrow has 30â70% blood stem cells, but in aplastic anemia, these cells are mostly gone and replaced by fat.
Management of High-Risk Disease. The optimal treatment for patients with very high-risk (VHR) acute lymphoblastic leukemia (ALL) has not been determined;however, some centers recommend allogeneic hematopoietic stem cell transplantation (HSCT) soon after first remission (CR1) is achieved.