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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
Well, letâs look at the facts. Zofran is a medication that is often prescribed for morning sickness during pregnancy. The official medical name for Zofran is ondansetron. It works by blocking serotonin receptors in the brain, which helps suppress the feeling of nausea.