This is of concern for the patients, because a delay in diagnosis and treatment favors the establishment of larvae in muscle tissue and the development of a collagen capsule, which leaves the larvae resistant to drugs (26, 138).pidemiological Investigation Outbreaks of trichinellosis can cause severe harm to the affected group of persons. By definition, a trichinellosis outbreak requires at least one case that must be laboratory confirmed (http://www.med.unipi.it/ict/outbr1.htm).
According to the American Cancer Society, the risk of developing endometrial cancer from tamoxifen is about 1 in 500 â a small risk, but higher than that for women in the general population. Tamoxifen also slightly increases the risk of uterine sarcoma, a cancer that begins in the muscle of the uterine wall.
Tamoxifen is a nonsteroidal anti-estrogenic drug that is metabolized in the liver. It has been used for decades as adjuvant treatment of breast cancer in menopausal women and more recently as a chemopreventive agent.