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The four most common teratogens are  tobacco, alcohol, medications and illegal drugs. Teratogens are substances that could harm a developing fetus by affecting growth and causing birth defects or death.
The central nervous and skeletal systems tend to be most affected by teratogens. Cigarette components, alcohol, cocaine, warfarin, ACE inhibitors, and Accutane are all teratogens that affect fetal development. Key Terms. teratogen: Any agent or substance that can cause embryonic malformations or birth defects.