Nail discoloration, in which the nails appear white, yellow, or green, can result from different infections and conditions of the skin. In about 50% of cases, discolored nails are a result of infections with common fungi that can be found in the air, dust, and soil.
Doxycycline is well absorbed. After an oral dose of 200 mg of doxycycline, plasma concentrations of the drug reach a maximum of 3 micrograms/mL at 2 hours and are well maintained and thus dosage once daily is usually adequate. Absorption is diminished by the presence of iron, aluminium, calcium and magnesium. Doxycycline is widely distributed into pleural and peritoneal fluid, saliva, semen and prostatic fluid. It passes the placental barrier readily and is also present in the milk of lactating patients.
Abstract. 1 The effects of two dihydropyridines, PY 108-068 (PY) and nicardipine (N), and two other calcium antagonists, verapamil (V) and diltiazem (D), on regional blood flow were measured in open-chest cats, anaesthetized with chloralose-urethane.2 Each substance was infused at 3 different dose rates, each for 10 min. Blood flow to stomach and small intestine was only slightly increased. Flow to the kidneys increased slightly in diltiazem-treated animals but did not change with all other treatments. Flow to the liver, the adrenals, and the spleen remained unchanged or showed a tendency to decrease.