Definition of substitution. 1  1a : the act, process, or result of substituting one thing for anotherb : replacement of one mathematical entity by another of equal value. 2  2 : one that is substituted for another.
Homogenized milk is any sort of milk that has been mechanically treated to ensure that it has a smooth, even consistency. The homogenization process typically involves high temperatures, agitation, and filtration, all aimed at breaking down milk's naturally occurring fat molecules.
While it is possible to have pasteurized milk that hasn't been homogenized and homogenized milk that hasn't been pasteurized, most milk found in U.S. supermarkets have undergone both processes.