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In clinical studies, Cialis began to work in as little as 30 minutes. For most people, though, it begins working within one hour. There are a number of factors that can increase or decrease how long Cialis lasts.
1 When used for treating erectile dysfunction, cialis works by increasing blood flow to the genital area. 2  Cialis is in a class of drugs known as PDE5 inhibitors. 3  This stands for phosphodiesterase 5 inhibitors.These drugs work on a certain enzyme, preventing the enzyme from working too fast.ialis will also not increase sexual desire. 1  When used for treating erectile dysfunction, cialis works by increasing blood flow to the genital area. 2  Cialis is in a class of drugs known as PDE5 inhibitors.