#1 of 3 B&Bs / Inns in Chenonceaux. â 1  Lives up to all its recommendations 2  â. We were welcomed to the maison with a smile and a much appreciated cup of... more. 3  December 16, 2016.
Induced fit hypothesis. Daniel Koshland's theory of enzyme-substrate binding is that the active site and the binding portion of the substrate are not exactly complementary. The induced fit model is a development of the lock-and-key model and assumes that an active site is flexible and it changes shape until the substrate is completely bound. The substrate is thought to induce a change in the shape of the active site.
when an enzyme binds to the appropriate substrate subtle changes in the active site occur this alteration of the active site is known as an induced fit induced fit enhances catalysis as the enzyme converts substrate to product replay release of the products restores the enzyme to its original form