Sponsored Topics. Oaktown is a town in Busseron Township, Knox County, Indiana, United States. The population was 608 at the 2010 census. Oaktown is located at 38Â°52â²17â³N 87Â°26â²25â³W / 38.87139Â°N 87.44028Â°W / 38.87139; -87.44028 (38.871331, -87.440163).
The pathophysiology of rheumatoid arthritis is mediated by an inter-related network of cytokines, proteolytic enzymes and prostanoids. IL-1, TNF-alpha, etc. are proinflammatory cytokines and are the central mediators in the disease.he pathophysiology of rheumatoid arthritis is mediated by an inter-related network of cytokines, proteolytic enzymes and prostanoids. IL-1, TNF-alpha, etc. are proinflammatory cytokines and are the central mediators in the disease.
Background. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown cause. The hallmark feature of this condition is persistent symmetric polyarthritis (synovitis) that affects the hands and feet, though any joint lined by a synovial membrane may be involved.he major difference between RA and other forms of inflammatory arthritis, such as psoriatic arthritis, lies not in their respective cytokine patterns but, rather, in the highly destructive potential of the RA synovial membrane and in the local and systemic autoimmunity.