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Thus, the ability of the partietal cell to secrete acid is dependent on active transport. The key player in acid secretion is a H+/K+ ATPase or proton pump located in the cannalicular membrane. This ATPase is magnesium-dependent, and not inhibitable by ouabain. Hydrogen ions are generated within the parietal cell from dissociation of water.
Purpose. Proton pump inhibitors are used to treat ulcers; gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus); and conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome.efinition. The proton pump inhibitors are a group of drugs that reduce the secretion of gastric (stomach) acid. They act by binding with the enzyme H+, K(+)-ATPase, hydrogen/potassium adenosine triphosphatase, which is sometimes referred to as the proton pump.