C. difficile diarrhea is largely a nosocomial disease and is the most frequent cause of diarrhea in hospitalized patients. Its occurrence in the outpatient setting, other than in patients confined to nursing homes, is much less common.
Darwin had arrived at a complete theory of evolution by 1839, but it was to be another 20 years before he published his ideas of evolution through natural selection in his epochal book On the Origin of Species by Means of Natural Selection.
In the early 19th century Jean-Baptiste Lamarck (1744 â 1829) proposed his theory of the transmutation of species, the first fully formed theory of evolution. In 1858 Charles Darwin and Alfred Russel Wallace published a new evolutionary theory, explained in detail in Darwin's On the Origin of Species (1859).