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Physical Concerns. Dry mouth is a red flag for other physical problems. For instance if an individual is diabetic and the disease is being poorly managed this can cause dry mouth during the night or dry mouth can be a sign that the individual has diabetes.
There are several causes of dry mouth: 1  Effects of certain medications. 2  Side effects of certain medical conditions, for example SjÃ¶gren's syndrome, and infections. 3  Side effect of certain medical treatments.  Nerve 1  damage. Dehydration.  Surgical removal of the salivary 1  glands. Lifestyle.