Sickle cell disease occurs from genetic changes that cause abnormalities in hemoglobin molecules: 1  Hemoglobin A (HbA) . 2  HbA is the hemoglobin molecule found in normal red blood cells during childhood and adulthood. 3  People who do not have sickle cell disease generally have this type of hemoglobin in their blood cells.ickle cell disease is an inherited blood disorder in which the body produces abnormally shaped red blood cells. In sickle cell disease, the hemoglobin in red blood cells clumps together. This causes red blood cells to become stiff and C-shaped.
A few new pregnancy symptoms will be noticed with the rise and fall of hormonal levels when you are 2 months pregnant. Your waistline is increasing even though you have not put on any significant weight. There is a change in the texture of the hair and skin during pregnancy.
For second and subsequent pregnancies, women often start showing sooner than during the first pregnancy. There are also some women do not look noticeably pregnant until they are into their third trimester. Early in pregnancy, you may be more vigilant in looking for changes. You may think you look pregnant more at the end of the day when you've eaten dinner and your muscles are more relaxed. You may have bloating or constipation that you didn't have before pregnancy that contributes to this. However, your uterus won't have expanded above your pelvis enough to be the cause of the bump until the second trimester. Changes in the first trimester often do not mean you need maternity clothes just yet.