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Tabletsprepared with microcrystalline cellulose withthe largest mean particle size (100 Âµm; AvicelPH-102) presented higher hardness, lower fri-ability and higher amount of drug released thanthose prepared with Avicel PH-101 (mean parti-cle size of 50 Âµm).
Metoprolol tartrate USP is a selective beta1-adrenoreceptor blocking agent, available as 25, 50 and 100 mg tablets for oral administration. Metoprolol tartrate is (Â±)-1-(isopropylamino)-3-[p-(2-methoxyethyl)phenoxy]-2-propanol (2:1) dextro-tartrate salt. Its structural formula is: Metoprolol tartrate USP is a white, practically odorless, crystalline powder with a molecular weight of 684.82. It is very soluble in water; freely soluble in methylene chloride, in chloroform, and in alcohol; slightly soluble in acetone; and insoluble in ether. Each tablet for oral administration contains 25 mg, 50 mg or 100 mg of Metoprolol tartrate.