Sponsored Topics. Oaktown is a town in Busseron Township, Knox County, Indiana, United States. The population was 608 at the 2010 census. Oaktown is located at 38Â°52â²17â³N 87Â°26â²25â³W / 38.87139Â°N 87.44028Â°W / 38.87139; -87.44028 (38.871331, -87.440163).
The pathophysiology of rheumatoid arthritis is mediated by an inter-related network of cytokines, proteolytic enzymes and prostanoids. IL-1, TNF-alpha, etc. are proinflammatory cytokines and are the central mediators in the disease.he pathophysiology of rheumatoid arthritis is mediated by an inter-related network of cytokines, proteolytic enzymes and prostanoids. IL-1, TNF-alpha, etc. are proinflammatory cytokines and are the central mediators in the disease.
Arthritis means joint inflammation. The joint inflammation of rheumatoid arthritis causes swelling, pain, stiffness, and redness in the joints. The inflammation of rheumatoid disease can also occur in tissues around the joints, such as the tendons, ligaments, and muscles. Rheumatoid arthritis is a chronic disease characterized by periods of disease flares and remissions. 2  In rheumatoid arthritis, multiple joints are usually, but not always, affected in a symmetrical pattern. 3  Chronic inflammation of rheumatoid arthritis can cause permanent joint destruction and deformity.