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Answer Wiki. Some knots can come out within a couple minutes. Others never come out. I've had extreme back and neck pain for the past year and a half, most of it just tension in my muscles. I've had numerous massages, taken other treatment, all to no avail.
Muscle knots, also called myofascial trigger points, are painful and can even be responsible for headaches. Caused by overuse, misuse, stress, or anxiety, muscles knots can be as hard to work out.