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Thus, the ability of the partietal cell to secrete acid is dependent on active transport. The key player in acid secretion is a H+/K+ ATPase or proton pump located in the cannalicular membrane. This ATPase is magnesium-dependent, and not inhibitable by ouabain. Hydrogen ions are generated within the parietal cell from dissociation of water.
First, ATP synthase is an enzyme located in the mitochondria of eukaryotic (animal) cells and the chloroplasts of plant cells. The energy currency that ATP synthase creates is called adenosine triphosphate (ATP). There are two components to ATP synthase, F1 and F0. F1 is composed of five subunits named after Greek letters: alpha, beta, gamma, delta, and epsilon.