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The four most common teratogens are  tobacco, alcohol, medications and illegal drugs. Teratogens are substances that could harm a developing fetus by affecting growth and causing birth defects or death.
PCT, the most common form of porphyria, comes in two clinical familial and a sporadic form: The familial form of PCT -- is inherited as an autosomal dominant trait with males and females affected in multiple generations. The enzyme UROD is reduced in all tissues. The sporadic form of PCT -- is more common. The enzyme UROD is only reduced in the liver.