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Alcohol dilates peripheral blood vessels, but has been known to actually. constrict some blood vessels in the brain, lowering the oxygen content. Alcohol dilates peripheral blood vessels, but has been known to actually  constrict some blood vessels in the brain, lowering the oxygen content.
Large amounts of alcohol can affect how the heart works. If the heart isn't pumping blood throughout the body effectively, other organs may suffer from lack of oxygen or nutrients. If the person drinking has clogged blood vessels, the heart has to work even harder.