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Mannitol Injection USP is one of the nonelectrolyte, obligatory, osmotic diuretics. It is freely filterable at the renal glomerulus, only poorly reabsorbed by the renal tubule, not secreted by the tubule, and is pharmacologically inert.
During monitoring, if osmolality, the osmotic gap, and findings such as a low sodium level return to normal, then treatment has been effective. With mannitol therapy, the monitoring goal is the maintenance of a stable therapeutic osmotic gap and the relief of cerebral edema.