NPH insulin has the advantage that it can be mixed with an insulin that has a faster onset to complement its longer lasting action, which is the primary reason NPH remains on the market today, because manufacturers sell a variety of premixed insulin formulations.
Wrap the foil tightly around the brisket to seal in heat and moisture while it cooks. Place the baking dish with the aluminum-wrapped brisket in the oven and bake for around one hour per pound of meat. Increase cooking time to 90 minutes per pound if you are cooking larger cuts of brisket, those weighing 8 to 12 pounds.
Cover the grill. 5. Smoke cook the brisket until tender enough to shred with your fingers; 6 hours will likely do it, but it may take as long as 8 (the cooking time will depend on the size of the brisket and heat of the grill). Baste the brisket from time to time with the fat and juices that accumulate in the pan.