NPH insulin has the advantage that it can be mixed with an insulin that has a faster onset to complement its longer lasting action, which is the primary reason NPH remains on the market today, because manufacturers sell a variety of premixed insulin formulations.
Wrap the foil tightly around the brisket to seal in heat and moisture while it cooks. Place the baking dish with the aluminum-wrapped brisket in the oven and bake for around one hour per pound of meat. Increase cooking time to 90 minutes per pound if you are cooking larger cuts of brisket, those weighing 8 to 12 pounds.
DO AHEAD: Brisket is best shortly off the grill, but you can still get good results smoking it up to 3 days ahead. Let cool for an hour before wrapping in foil and chilling. To serve, reheat meat, still wrapped, in a 325-degree oven until warmed through.