Definition of NEUROFIBRILLARY TANGLE. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.weet. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.
Stephen King Books In Order. On April 5, 1974, Stephen King released Carrie â the first of his novels to be published. Since then, heâs released more than 100 books, novellas, short stories, poems and screenplays, selling more than 350 million copies in the process.
Before James and the Giant Peach, Dahl, who was from England, had only written stories for adults, but in 1959, he began writing for children. He proved to be a talented children's author. James and the Giant Peach became very popular and is still read by many children today. Dahl published the book in 1961 in the United States, with the same publisher he had worked with on some of his short stories for adults, Alfred A. Knopf.