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Imipramine (Tofranil) is the medication for panic disorder that has been most thoroughly studied, with at least 10 double-blind, placebo-controlled studies supporting its efficacy in the acute treatment of panic disorder.6 Clomipramine (Anafranil) has shown similar results in several double-blind trials as well.
Anticonvulsants commonly used to stabilize mood include valproic acid (considered one of the most effective), carbamazepine, lamotrigine, topiramate, and gabapentin. Anticonvulsants are an effective mood-stabilizing treatment for bipolar disorder.