NPH insulin has the advantage that it can be mixed with an insulin that has a faster onset to complement its longer lasting action, which is the primary reason NPH remains on the market today, because manufacturers sell a variety of premixed insulin formulations.
Wrap the foil tightly around the brisket to seal in heat and moisture while it cooks. Place the baking dish with the aluminum-wrapped brisket in the oven and bake for around one hour per pound of meat. Increase cooking time to 90 minutes per pound if you are cooking larger cuts of brisket, those weighing 8 to 12 pounds.
A brisket should rest at least 30 minutes and up to 2 to 4 hours in a warm ice chest. Using the 1 to 1.5 hour rule and your brisket is around 12 pounds, a cooking time of between 12 and 18 hours depending on the above mentioned factors. brisket should rest at least 30 minutes and up to 2 to 4 hours in a warm ice chest. Using the 1 to 1.5 hour rule and your brisket is around 12 pounds, a cooking time of between 12 and 18 hours depending on the above mentioned factors.