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Thus, the ability of the partietal cell to secrete acid is dependent on active transport. The key player in acid secretion is a H+/K+ ATPase or proton pump located in the cannalicular membrane. This ATPase is magnesium-dependent, and not inhibitable by ouabain. Hydrogen ions are generated within the parietal cell from dissociation of water.
A proton motive force can be tapped by protein complexes known as ATP synthases , which are reverse-running proton pumps that allow protons to cross membranes but in a manner that the drive of these protons to move from regions of high proton concentration to regions of low proton concentration ( i.e. , down their concentration gradient ) captured ...