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But denosumab is a first-in-class drug: It's a biologic, which means it will likely be much more expensive than its competitor drugs, some of which are available as cheaper generics. The drug also boasts an extremely convenient dosing regimen -- subcutaneous injection every six months.
Advantages. Prolia stays in a patientâs system for only a finite period of time, and Siris says this reversibility could be one appeal. âAt the end of six months, if you donât get another dose, itâs gone. So if you felt you didnât want to use this approach, itâs gone after the six months after the dose is given.