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Imipramine (Tofranil) is the medication for panic disorder that has been most thoroughly studied, with at least 10 double-blind, placebo-controlled studies supporting its efficacy in the acute treatment of panic disorder.6 Clomipramine (Anafranil) has shown similar results in several double-blind trials as well.
Although most of the medications for anxiety disorder are only available with a prescription, a few OTC medications could be considered for anxiety. Benadryl, or diphenhydramine, can be used to reduce anxiety symptoms.