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Up-regulation is a process that occurs within a cell triggered by a signal (originating internal or external to the cell), which results in increased expression of one or more genes and as a result the protein(s) encoded by those genes.
The answer would be Cyclins are proteins that regulate when and how often a cell divides. Cyclins belong to a family of proteins that control the progression of a cell through its respective cell cycle. This is initiated by activating cyclin-dependent kinase (CDK) enzymes which regulate transcription of RNA and process mRNA during mitosis.