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Mild Flu Shot Reactions. Mild Flu shot reactions include soreness, redness or swelling where the shot was given, hoarseness; sore, red or itchy eyes; cough, fever, and aches. A reaction to Flu vaccine continue they usually begin soon after the shot and last 1-2 days. Severe Flu Shot Reactions. Severe Flu shot reactions include allergic reactions. CDC says however that a life-threatening reaction to Flu vaccine is very rare. If Flu shot reactions occur, it is usually within a few minutes to a few hours after the vaccine.
1 In some years, the influenza viruses used for the vaccine don't match the viruses circulating during the flu season. 2  If this occurs, your flu shot will be less effective, but may still offer some protection. 3  Other illnesses. 4  Many other diseases, such as the common cold, also produce flu-like symptoms.