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Pulmonary hypertension is high blood pressure within the artery that connects the lungs and heart. It forces the heart to work harder to transfer blood between the heart and lungs, which may lead to an enlargement of the right side. Thyroid problems, whether they involve an underactive or overactive thyroid, can cause a heart to enlarge.
Pain on the right side of the chest is unlikely to be related to heart disease in women. Conditions which can affect this side include: Gallstones Gallstones are the most common cause of severe and constant pain on the right side. Muscle Strain Muscle pain can occur due to overexertion or lifting a heavy object.