#1 of 3 B&Bs / Inns in Chenonceaux. â 1  Lives up to all its recommendations 2  â. We were welcomed to the maison with a smile and a much appreciated cup of... more. 3  December 16, 2016.
Induced fit hypothesis. Daniel Koshland's theory of enzyme-substrate binding is that the active site and the binding portion of the substrate are not exactly complementary. The induced fit model is a development of the lock-and-key model and assumes that an active site is flexible and it changes shape until the substrate is completely bound. The substrate is thought to induce a change in the shape of the active site.
lock and key theory In this analogy, the lock is the enzyme and the key is the substrate. Only the correctly sized key (substrate) fits into the key hole (active site) of the lock (enzyme). Induced Fit Theory The induced-fit theory assumes that the substrate plays a role in determining the final shape of the enzyme and that the enzyme is partially flexible.