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The four most common teratogens are  tobacco, alcohol, medications and illegal drugs. Teratogens are substances that could harm a developing fetus by affecting growth and causing birth defects or death.
A teratogen is any agent that causes abnormalities when a developing baby is exposed to it during the mother's pregnancy. These environmental exposures can cause birth defects and other problems. 1  Teratogens are can have effects that range from mild to severe, and they are often most dangerous during early pregnancy and with excessive or prolonged exposure. There are several factors that influence the severity of the effect: