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Pulmonary hypertension is high blood pressure within the artery that connects the lungs and heart. It forces the heart to work harder to transfer blood between the heart and lungs, which may lead to an enlargement of the right side. Thyroid problems, whether they involve an underactive or overactive thyroid, can cause a heart to enlarge.
Causes of Pain in Right Chest Area. Pain in the right chest area is caused by numerous factors. The most common causes are gallbladder problems, angina and costochondritis. In some cases, the problem arises from chronic medical conditions like hiatal hernia, irritation of the esophagus as well as ulcer.