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Bactrim is a sulfa-based antibiotic and is not a penicillin-based medicine, according to RxList. However, a patient should discuss all allergies with a doctor to determine what drugs can and cannot be taken. Continue Reading.
Answers. Best Answer: Bactrim is in the classification of anti-infectives called sulfonamides and is a combination of sulfamethoxazole and trimethoprim called co-trimoxazole. It's used to treat UTIs caused by strains of E. coli, Proteus, Klebsiella or Enterocobacter.