The large scope of potential global public health threats is recognized in the revised International Health Regulations (IHR [2005])3 with its all-hazards approach to assessing serious public health threats.
How much is it? On average, a high-quality peridot stone can cost anywhere from $50 to $200+ per carat. Larger peridots that are exported from foreign countries can cost as much as $500+ per carat. Generally, stones mined from Burma, Pakistan and Arizona can command the highest prices.
So the Jeweled Onyx Panther costs about 95K* in raw materials alone. *(Marathal noted on twitter that there is a 10% discount available via a guild perk on the Orb of Mystery which would could bring the cost down to 18K. That would bring the total mat cost down around 93K.