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Answer Wiki. Some knots can come out within a couple minutes. Others never come out. I've had extreme back and neck pain for the past year and a half, most of it just tension in my muscles. I've had numerous massages, taken other treatment, all to no avail.
Muscle Knots in the Back That Are Big & Hard to Get Out. Knots in your back muscles can cause radiating pain that affects your entire body. Photo Credit Comstock Images/Comstock/Getty Images. Muscle knots in your back can be painful, especially if they are big and aren't going away. Some knots may cause mild discomfort, while others may affect your ability to sleep, work and move.