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Answer Wiki. Some knots can come out within a couple minutes. Others never come out. I've had extreme back and neck pain for the past year and a half, most of it just tension in my muscles. I've had numerous massages, taken other treatment, all to no avail.
Since the muscles are not designed to be under constant stress, it is extremely essential that the stress or load is taken off as the muscles relax in the passive mode. If any activity acts as a trigger and causes the neck muscles to stay under constant tension, one is most likely to develop tension knots. Though some practitioners cite the accumulation of abnormal protein deposits within the muscle tissue as the triggering factor behind the development of muscle knots in the neck area, this theory has not been corroborated by medical research.