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Overview[edit] A carbonic anhydrase, or carbonate dehydratase, is a type of enzyme that rapidly catalyzes the conversion of carbon dioxide into a proton and the bicarbonate ion (HCO3-).
pH affects carbonic anhydrase in a sigmoidal fashion. The higher the pH, the more active the enzyme is (since it is in the optimal conditions for deprotonation). 1) The binding of zinc lowers the pKa of water from 15.7 to 7, generating a hydroxide ion (OH) to attack carbon dioxide.