1 A physical change, such as a state change or dissolving, does not create a new substance, but a chemical change does. 2  In a chemical reaction, the atoms and molecules that interact with each other are called reactants. 3  In a chemical reaction, the atoms and molecules produced by the reaction are called products. In a chemical reaction, the atoms and molecules produced by the reaction are called products. 2  In a chemical reaction, only the atoms present in the reactants can end up in the products. 3  No new atoms are created, and no atoms are destroyed.
Humira (adalimumab) is a biologic drug that works by blocking a protein known as TNF-alpha. Normally, TNF-alpha helps fight infection, but in excess amounts, it can cause painful inflammation and severe joint damage -- common symptoms of rheumatoid arthritis and other forms of inflammatory arthritis.
When Abbott engineered its $6.9 billion acquisition of Knoll Pharmaceuticals, which developed Humira, Wall Street analysts and investors thought the company spent too much. The drug industry at the time often touted the cost of researching and developing one drug at $800 million or more.