Definition of NEUROFIBRILLARY TANGLE. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.weet. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.
Stephen King Books In Order. On April 5, 1974, Stephen King released Carrie â the first of his novels to be published. Since then, heâs released more than 100 books, novellas, short stories, poems and screenplays, selling more than 350 million copies in the process.
This article is about a novel. For the film, see Cujo (film). For the character, see Cujo. Cujo is the twelfth book published by Stephen King; it is his tenth novel, and the seventh novel under his own name. The book was released by Viking on 8 September 1981. The story is set almost entirely in the fictional town of Castle Rock, Maine.