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Tabletsprepared with microcrystalline cellulose withthe largest mean particle size (100 Âµm; AvicelPH-102) presented higher hardness, lower fri-ability and higher amount of drug released thanthose prepared with Avicel PH-101 (mean parti-cle size of 50 Âµm).
DRUG DESCRIPTION. Betapace/Betapace AF contains sotalol hydrochloride, an antiarrhythmic drug with Class II (betaadrenoreceptor blocking) and Class III (cardiac action potential duration prolongation) properties. Betapace is supplied as a light-blue, capsule-shaped tablet for oral administration. Betapace AF is supplied as a white, capsule-shaped tablet for oral administration. Sotalol hydrochloride is a white, crystalline solid with a molecular weight of 308.8. It is hydrophilic, soluble in water, propylene glycol and ethanol, but is only slightly soluble in chloroform.