Definition of NEUROFIBRILLARY TANGLE. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.weet. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.
Stephen King Books In Order. On April 5, 1974, Stephen King released Carrie â the first of his novels to be published. Since then, heâs released more than 100 books, novellas, short stories, poems and screenplays, selling more than 350 million copies in the process.
Published in 1937, this was Seussâ first children's book. His original title for the book was âA Story That No One Can Beat.â Maybe this was the reason it was rejected by 27 publishers before eventually being picked up by Vanguard Press. Yes, it seems nearly 30 publishers couldnât figure out a way to make money off a silly Dr. Seuss book. 6.