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Adrenaline is one of the body's most important stress chemicals. It is secreted from the adrenal glands, which sit atop each kidney. Adrenaline also plays a key role as a neurotransmitter that facilitates communication between brain cells, or neurons, and other cells. An adrenaline rush is a sudden increased secretion of adrenaline from the adrenal glands. It causes an increase in heart rate and respiration. Adrenaline rushes can be healthy responses to actual threats to a person's well-being or symptoms of an underlying mental disorder.
Adrenal Gland Insufficiency Caused by ACTH Deficiency. Adrenal gland insufficiency happens when your adrenal gland, a small gland near your kidneys, does not make enough of a hormone called cortisol. Your pituitary gland makes a hormone called adrenocorticotropic hormone (ACTH). This hormone tells your adrenal glands to release cortisol. You need cortisol to maintain healthy blood pressure.