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Pulmonary hypertension is high blood pressure within the artery that connects the lungs and heart. It forces the heart to work harder to transfer blood between the heart and lungs, which may lead to an enlargement of the right side. Thyroid problems, whether they involve an underactive or overactive thyroid, can cause a heart to enlarge.
The condition can affect the right side of the heart only, or it can affect both sides of the heart. Most cases involve both sides of the heart. Right-side heart failure occurs if the heart can't pump enough blood to the lungs to pick up oxygen.he condition can affect the right side of the heart only, or it can affect both sides of the heart. Most cases involve both sides of the heart. Right-side heart failure occurs if the heart can't pump enough blood to the lungs to pick up oxygen.