1 A physical change, such as a state change or dissolving, does not create a new substance, but a chemical change does. 2  In a chemical reaction, the atoms and molecules that interact with each other are called reactants. 3  In a chemical reaction, the atoms and molecules produced by the reaction are called products. In a chemical reaction, the atoms and molecules produced by the reaction are called products. 2  In a chemical reaction, only the atoms present in the reactants can end up in the products. 3  No new atoms are created, and no atoms are destroyed.
Humira (adalimumab) is a biologic drug that works by blocking a protein known as TNF-alpha. Normally, TNF-alpha helps fight infection, but in excess amounts, it can cause painful inflammation and severe joint damage -- common symptoms of rheumatoid arthritis and other forms of inflammatory arthritis.
Humira costs approximately $3,100 per month, like the TNFÎ± inhibitor etanercept. From 2012 to US patent expiry in 2016, Humira led the list of top-selling pharmaceutical products, and in 2016, it had $16 billion of global sales. Also in 2014, in India, the first adalimumab biosimilar came to market at a price of $200.