In the early 2000s, the concept of injecting the prostate transperineally with a combination of steroids (betamethasone) and antibiotics (to prevent the steroid-induced local immunosuppression leading to abscess) gained currency through the efforts of European practitioners, and especially Dr Federico Guercini of Rome, Italy.
Fifty-six delegates to the Second Continental Congress in Philadelphia signed the United States Declaration of Independence, a statement announcing that the thirteen American colonies then at war with Great Britain were now independent states, and thus no longer a part of the British Empire.lthough the wording of the Declaration was approved by Congress on July 4, 1776, the date of its signing has been disputed.
The city and state where the Declaration of Independence was signed  was Philadelphia, Pennsylvania. It was at The Independence Hall.