Definition of NEUROFIBRILLARY TANGLE. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.weet. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.
Stephen King Books In Order. On April 5, 1974, Stephen King released Carrie â the first of his novels to be published. Since then, heâs released more than 100 books, novellas, short stories, poems and screenplays, selling more than 350 million copies in the process.
Adventures of Huckleberry Finn is a novel by Mark Twain, first published in the United Kingdom in December 1884 and in the United States in February 1885. Commonly named among the Great American Novels, the work is among the first in major American literature to be written throughout in vernacular English, characterized by local color regionalism. It is told in the first person by Huckleberry Huck Finn, the narrator of two other Twain novels and a friend of Tom Sawyer. It is a direct sequel to