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The four most common teratogens are  tobacco, alcohol, medications and illegal drugs. Teratogens are substances that could harm a developing fetus by affecting growth and causing birth defects or death.
Causes of teratogenesis can broadly be classified as: 1  Toxic substances, such as, for humans, drugs in pregnancy and environmental toxins in pregnancy. 2  Vertically transmitted infection. 3  Lack of nutrients. 4  Physical restraint. 5  Genetic disorders. 6  Alcohol consumption during pregnancy.