#1 of 3 B&Bs / Inns in Chenonceaux. â 1  Lives up to all its recommendations 2  â. We were welcomed to the maison with a smile and a much appreciated cup of... more. 3  December 16, 2016.
Induced fit hypothesis. Daniel Koshland's theory of enzyme-substrate binding is that the active site and the binding portion of the substrate are not exactly complementary. The induced fit model is a development of the lock-and-key model and assumes that an active site is flexible and it changes shape until the substrate is completely bound. The substrate is thought to induce a change in the shape of the active site.
Lock and key = saying that substrate fits the enzyme, like a key fits a lock-which isn't true in the sense that the substrate binding would change the active site, which is the induced fit hypothesis.ock and key = saying that substrate fits the enzyme, like a key fits a lock-which isn't true in the sense that the substrate binding would change the active site, which is the induced fit hypothesis.