Definition of NEUROFIBRILLARY TANGLE. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.weet. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.
Stephen King Books In Order. On April 5, 1974, Stephen King released Carrie â the first of his novels to be published. Since then, heâs released more than 100 books, novellas, short stories, poems and screenplays, selling more than 350 million copies in the process.
The following works of literature have each been claimed as the first novel in English. 1  Thomas Malory, Le Morte d'Arthur, (written c. 1470, published 1485) 2  William Baldwin, Beware the Cat, (written 1553, published 1570, 1584) 3  John Lyly, Euphues: The Anatomy of Wit (1578) and Euphues and his England (1580)