Sickle cell disease occurs from genetic changes that cause abnormalities in hemoglobin molecules: 1  Hemoglobin A (HbA) . 2  HbA is the hemoglobin molecule found in normal red blood cells during childhood and adulthood. 3  People who do not have sickle cell disease generally have this type of hemoglobin in their blood cells.ickle cell disease is an inherited blood disorder in which the body produces abnormally shaped red blood cells. In sickle cell disease, the hemoglobin in red blood cells clumps together. This causes red blood cells to become stiff and C-shaped.
A few new pregnancy symptoms will be noticed with the rise and fall of hormonal levels when you are 2 months pregnant. Your waistline is increasing even though you have not put on any significant weight. There is a change in the texture of the hair and skin during pregnancy.
On average, pregnant women begin showing during the second trimester, around 12 to 16 weeks. Normally, your uterus is the size of a lemon. By weeks 14 to 17 of your pregnancy, itâs about the size of a small melon and has risen above the pelvic cavity, making it visible above your waistline. At this point, youâll probably need to shop for maternity clothes if you havenât done so already. Early in pregnancy, some women have a âcome-and-goâ belly. Your belly may feel expanded one day and the next day, after youâve had a bowel movement, it disappears. This full belly-flat belly phenomenon, while a little unsettling, is normal.