Osaka: Annual Weather Averages. August is the hottest month in Osaka with an average temperature of 29Â°C (84Â°F) and the coldest is January at 6Â°C (43Â°F) with the most daily sunshine hours at 6.7 in August. The wettest month is June with an average of 230mm of rain.
Warfarin begins to reduce blood clotting within 24 hours after taking the drug. The full effect may take 72 to 96 hours to occur. The anti-clotting effects of a single dose of warfarin lasts 5. two to five days, but it is important for you to take your dose as prescribed by your healthcare provider.
However, in a clinical study with coadministration of TRINTELLIX (10 mg/day) and warfarin (1. mg/day to 10 mg/day), a highly protein-bound drug, no significant change in INR was observed. [see Drug Interactions (7.2)].