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Causes of cardiovascular disease. While cardiovascular disease can refer to different heart or blood vessel problems, the term is often used to mean damage to your heart or blood vessels by atherosclerosis (ath-ur-o-skluh-ROE-sis), a buildup of fatty plaques in your arteries.
Key Facts. Many risks for heart disease and strokeâincluding high blood pressure and high cholesterolâmay not have any symptoms. Many of these risksâspecifically high blood pressure, high cholesterol, smoking, and obesityâare preventable and controllable. Controlling these risks could reduce your risk for heart attack or stroke by more than 80%. About 160,000 people who died from cardiovascular disease in 2014 were younger than age 65.