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How long does it take for an antibiotic to work? Well, it depends upon the type of antibiotic and how serious the infection is. Most antibiotics should work between 24-48 hours. Use the information in this article to decipher whether it is worth waiting or if you should call the doctor, nurse or pharmacist for input. Antibiotics directions and instructions.
Quick Answer. Although an antibiotic's half-life equals half the time it takes to leave an individual's system, it takes five half-lives for the drug to clear a person's system completely, according to HealthTap. Each drug has its own specific half-life, so different antibiotics remain in the system for different lengths of time. Keep Learning.