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The drugâs initial approval noted mild side effects such as vomiting, itching, lethargy and diarrhea. Some 70 million doses of Trifexis have been distributed through 15,000 veterinary clinics, said Elanco spokeswoman Julie Lawless.
Cumulative Effect of Drugs. 1. Due to too frequent doses. 2. Due to too long continued administration. By cumulative effect is meant the unexpected, intense action of a drug after it has been given for some time, as differing from an immediate intense action of a drug which would show an idiosyncrasy.1.. Cumulative Action From Too Long Continued Administration of a Drug means the development of symptom a which show an over-action of the drug. This is of frequent occurrence and is sometimes accidental, but is often caused deliberately by pushing a drug to its full physiologic effect.