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Causes of cardiovascular disease. While cardiovascular disease can refer to different heart or blood vessel problems, the term is often used to mean damage to your heart or blood vessels by atherosclerosis (ath-ur-o-skluh-ROE-sis), a buildup of fatty plaques in your arteries.
Types affecting the blood vessels include stroke, high blood pressure, and aortic aneurism. Cardiovascular disease (CVD) is not one single disease or condition. It is a group of different disorders that affect your heart and blood vessels.