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Responses (1) takes 24 hours for antibiotic to start working but it could take several days to feel better. You didnt say why you were taking it, it is used alot for urinary tract infections and bladder infections. If this is the case you should drink as much water as you can and this will help also.
How long does it take for antibiotics to work for kidney inf. Report Share. Just been prescribed ciprofloxacin for kidney infection wondering how long it take to work, was told 48 hours by GP but still feel really ill after 4 days.Never had this before so not sure how long it will last.eport Share. Just been prescribed ciprofloxacin for kidney infection wondering how long it take to work, was told 48 hours by GP but still feel really ill after 4 days. Never had this before so not sure how long it will last.