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DIGOXIN USES. Digoxin is used to slow down the rate of the heart, but increase the force with which the heart muscle contracts. It is a cardiac glycoside. It is used to make the heart work efficiently. In general this drug is used to treat heart failure and irregular heart beats or irregular heart rhythm (including atrial flutter or fibrillation). Benefits of being on this drug can include reduction of ventricular rate. Listed below are the typical uses of digoxin.