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How long does it take for an antibiotic to work? Well, it depends upon the type of antibiotic and how serious the infection is. Most antibiotics should work between 24-48 hours. Use the information in this article to decipher whether it is worth waiting or if you should call the doctor, nurse or pharmacist for input. Antibiotics directions and instructions.
If you get the right antibiotic it can be as little as 2 doses - 24 hours for the swelling to goâ¦ down. Sometimes it can take 3 or 4 doses to go down - about 48 hours. If you have been on an antibiotic for 3 days and there is no change in the swelling, you should call your doctor. You may need a stronger antibiotic or a different class of antibiotics.