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Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. Structure.
BRAND NAME: Lunesta (formerly known as Estorra). DRUG CLASS AND MECHANISM: Eszopiclone is a non-benzodiazepine, oral, sedative drug (sleeping pill) that is used for treating insomnia. According to the National Institutes of Health, more than 50 million Americans suffer from insomnia.ost drugs that have been used to treat insomnia are benzodiazepines, for example, flurazepam (Dalmane), lorazepam (Ativan), triazolam (Halcion), and temazepam (Restoril). Zolpidem (Ambien) was the first non-benzodiazepine approved for insomnia in over 20 years. Eszopiclone was approved by the FDA in December 2004.