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How does an ACE Inhibitor work? ACE inhibitors prevent an enzyme in your body from producing angiotensin II, a substance that affects your cardiovascular system by narrowing your blood vessels and releasing hormones that can raise your blood pressure. This narrowing can cause high blood pressure and force your heart to work harder. ACE inhibitors also increase blood flow, which helps to decrease the amount of work your heart has to do and can help protect your kidneys from the effects of hypertension (high blood pressure).
But your doctor may prescribe an ACE inhibitor for these other heart conditions: Heart failure: They can prevent further weakening of your heart and prolong your life. Heart attack: When given after one, some ACE inhibitors may lessen the impact on your heart strength and help you live longer. Diabetes: Some can slow the process that leads to kidney damage in many people with type 2 diabetes.