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A gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people.Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes.hese changes can be caused by environmental factors such as ultraviolet radiation from the sun, or can occur if a mistake is made as DNA copies itself during cell division. Acquired mutations in somatic cells (cells other than sperm and egg cells) cannot be passed on to the next generation.
Gene mutation is basically the change in the nucleotide sequence while chromosome mutation is the change in several genes. These gene mutations are basically small changes in the gene while chromosome mutation is the alteration that happens on a large scale.. Gene mutation. Gene mutation is considered as the small scale change in a nucleotide sequence. The altering of the genetic material on an organism happens in two ways. Point mutations and frame shift mutations are two bases which play a vital role whenever any change happens in a nucleotide sequence.