Vonage Holdings Corp. founder, chairman and chief strategist Jeffrey Citron celebrates his company's IPO with then-New York Stock Exchange CEO John Thain after the opening bell on May 24, 2006. The celebration wouldn't last long. An initial public offering (IPO) is often described as a company's coming out party..
Blepharospasm is caused by abnormal brain function in the part of your brain that controls muscles. Symptoms can be triggered by something as minor as stress and being overly tired. Or it could be triggered by a neurological condition. Such conditions would include Touretteâs syndrome or Parkinsonâs disease.
Pathophysiology. Achondroplasia is caused by mutations in the fibroblast growth factor receptor-3 (FGFR3) gene. Mutations within FGFR3 are the only genetic changes known to cause achondroplasia. FGFR3 has been mapped to the short arm of chromosome 4, p16.3 (4p16.3).ackground. Achondroplasia, a nonlethal form of chondrodysplasia, is the most common type of short-limb dwarfism. This skeletal dysplasia is inherited as a Mendelian autosomal dominant trait with complete penetrance.