Hox gene is an example of a homeobox gene. The homeobox sequence codes for a 60 amino acid protein domain known as the homeodomain. The main role of homeodomain is to act as a switch that controls gene transcription.
(Histone modification hassome attributes of an epigenetic process, but the issue ofheritability has yet to be resolved.) This review concernsDNA methylation, focusing on the generation, inheri-tance, and biological significance of genomic methyl-ation patterns in the development of mammals.
DNA Replication - synchronization of leading and lagging strands. DNA is replicated by continuous synthesis of a leading strand and discontinous synthesis of a lagging strand. Coordination between leading and lagging strand synthesis is achieved by the dimerization of DNA polymerase molecules at the replication fork. The DN A polymerase dimer moves with the replication fork. the polymerase at the leading strand template remains attached to the DNA, synthesizing the leading strand continuously. The lagging strand polymerase initiates DNA synthesis at the fork, from an RNA primer made by a primase complex.