Related Terms. 1  annual gross income. 2  exclusion ratio. 3  gift tax. 4  creditable coverage. 5  annual exclusion. 6  mutually exclusive investment decisions. 7  foreign housing exclusion. 8  mutual exclusion doctrine. 9  low exercise price option (LEPO). 10  foreign earned income exclusion.
Methaqualone was first synthesized in India in 1955 by scientists trying to find a cure for malaria. The drug was ineffective against the disease, but not as a central nervous system depressant â and if a user could resist its sedative effects, a user could get high.
Because the high dosages used in preliminary testing of methadone caused substantial side effects, the drug was not used clinically for several years.1 During the 1950s, methadone emerged as a treatment for opioid addiction and has remained the primary therapy for this condition for more than 40 years.