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Responses (1) takes 24 hours for antibiotic to start working but it could take several days to feel better. You didnt say why you were taking it, it is used alot for urinary tract infections and bladder infections. If this is the case you should drink as much water as you can and this will help also.
1 73% - How long does it take for a rocephin shot to work for an ear infection? 2  44% - I had a rocephin shot yesterday for urinary infection.how long will it take to work? 3  53% - How soon should a rocephin shot along w/ a steroid shot work?evere ear infection in my child, MD only ordered 1 shot of Rocephin, how long does it take for this antibiotic to start relieving symptoms of ear infection.