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Responses (1) takes 24 hours for antibiotic to start working but it could take several days to feel better. You didnt say why you were taking it, it is used alot for urinary tract infections and bladder infections. If this is the case you should drink as much water as you can and this will help also.
I have a bad sinus infection pressure in head and face my doctor gave me amoxicillin antibiotics. How long does it take for the medicine to start working? it&#39;s the 3rd day and I don&#39;t notice anything yet...inus infections can take from a couple of weeks to a month for antibiotics to clear up. It takes the drugs a long time to get into all that pus in your sinuses and to have an effect.