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7 Hpw long would it take for (1) 81mg of aspirin to be completely out of your system...On for about 1 year. Dr. Venkata Chilakapati Dr. Chilakapati. Aspirin: For small dose of Aspirin elimination half life is 2 to 4.5 hours. So within 24 hours it will be completely eliminated from the body.
Retrospective analyses of several recent large-scale clinical trials found a consistent lack of any increased benefit with higher dosages of aspirin (75 mg/day versus 325 mg/day). At a mean follow-up of 366 days in the BRAVO trial studying recent MI and stroke, there were no differences for all-cause mortality, MI, stroke, or urgent revascularization, with a trend favoring lower doses, the researchers found.