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Responses (1) takes 24 hours for antibiotic to start working but it could take several days to feel better. You didnt say why you were taking it, it is used alot for urinary tract infections and bladder infections. If this is the case you should drink as much water as you can and this will help also.
How long does fluconazole take to work? You should be able to notice significant improvement within 24 hours, but sometimes it can take as long as 3 days for your symptoms to disappear. In some cases you may have to wait up to 7 days to completely recover from a vaginal yeast infection.