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How long does it take for an antibiotic to work? Well, it depends upon the type of antibiotic and how serious the infection is. Most antibiotics should work between 24-48 hours. Use the information in this article to decipher whether it is worth waiting or if you should call the doctor, nurse or pharmacist for input. Antibiotics directions and instructions.
How long does it take for antibiotics to work for kidney inf. Report Share. Just been prescribed ciprofloxacin for kidney infection wondering how long it take to work, was told 48 hours by GP but still feel really ill after 4 days.Never had this before so not sure how long it will last.eport Share. Just been prescribed ciprofloxacin for kidney infection wondering how long it take to work, was told 48 hours by GP but still feel really ill after 4 days. Never had this before so not sure how long it will last.