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Kohlerâs disease is a rare condition in which the tarsal navicular bone (a bone in the arch of the foot) becomes inflamed. This bone disease is named after the German radiologist who described the condition in the early twentieth century. Kohlerâs disease usually affects children between the ages of three and five. It occurs more commonly in boys than in girls, and is often unilateral, affecting one foot. It is described as an avascular necrosis, or osteonecrosis, in which bone tissue deteriorates due to an interruption of blood supply.
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease that rapidly, progressively and severely affects the brain. Creutzfeldt-Jakob disease is one cause of dementia and results in the destruction of brain cells in the brain.Creutzfeldt-Jakob disease eventually leads to the development of many tiny holes in the brain.The disease was first described by German neurologist Hans Gerhard Creutzfeldt in 1920, and shortly afterwards by Alfons Maria Jakob, giving it the name Creutzfeldt-Jakob.ymptoms of Creutzfeldt-Jakob disease occur most often in the elderly, after the age of 60. Symptoms are due to the destruction of brain cells and include neurological symptoms, such as memory loss, blindness, and poor coordination.