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Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. Structure.
Pioglitazone is used for treating type 2 diabetes in people who cannot lower blood sugar through lifestyle changes (such as weight loss, diet, and exercise). The drug is part of a group of diabetes medications called thiazolidinediones (or sometimes called glitazones).ioglitazone Uses: An Overview. Pioglitazone hydrochloride (Actos Â®) is a prescription medicine that has been licensed to treat type 2 diabetes. The drug can be used alone or in combination with other diabetes medications. Pioglitazone cannot be used to treat type 1 diabetes (see Actos and Type 1 Diabetes) .