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Large red blood cells aka Macrocytosis is a common effect caused by Vitamin B12/Folate deficiency anemia.Common causes are a vegan diet, because Vitamin B12 comes from foods from animal origin.arge red blood cells aka Macrocytosis is a common effect caused by Vitamin B12/Folate deficiency anemia.
Best Answer: Occasional large platelets are a common finding on normal peripheral blood smears. They represent younger platelets, and in the clinical situation of increased WBC counts with an infection, indicate an active bone marrow. Do not be concerned. had routine bloodwork done and I had high WBC and large platelets. my mother had APL (type of leukemia) thoughts???? I currently have an infection so maybe that's why the white blood cells are high, but what exactly do large platelets mean? I've googled but most answers talk about platelet COUNT and not SIZE.