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Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive effect measured at trough using once-aday dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
Losartan is used to treat high blood pressure and decrease the risk of stroke in people who have high blood pressure and an enlarged heart. Certain side effects can be serious. Losartan may not decrease the risk of stroke in African Americans who have these conditions. The medication is also used in the treatment of kidney disease in those with type 2 diabetes and high blood pressure.