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A gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people.Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes.hese changes can be caused by environmental factors such as ultraviolet radiation from the sun, or can occur if a mistake is made as DNA copies itself during cell division. Acquired mutations in somatic cells (cells other than sperm and egg cells) cannot be passed on to the next generation.
Answer Wiki. 1 Answer. , Devoted to the Chromosome. A gene is a unit of genetic material (DNA or RNA) that leads to a certain trait. A mutation in that gene that leads to an alternate version means that there are now 2 alleles (specific versions) of that gene: the standard allele and the mutant allele.