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Responses (1) takes 24 hours for antibiotic to start working but it could take several days to feel better. You didnt say why you were taking it, it is used alot for urinary tract infections and bladder infections. If this is the case you should drink as much water as you can and this will help also.
2 doctors agreed: 24 to 72 hours: Antibiotics can start providing relief anywhere from 24 to 72 hours. If you don't have any relief by 72 hours you should call your dentist as you might need a different antibiotic or an emergency dental treatment. For temporary relief you can take OTC NSAIDs or Tylenol (acetaminophen).