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7 Hpw long would it take for (1) 81mg of aspirin to be completely out of your system...On for about 1 year. Dr. Venkata Chilakapati Dr. Chilakapati. Aspirin: For small dose of Aspirin elimination half life is 2 to 4.5 hours. So within 24 hours it will be completely eliminated from the body.
Despite these shortcomings it has a lot of beneficial effects and it is inexpensive. The currently recommended dosage of aspirin varies a little from publication to publication but it is between 5 and 15mg/lb every 12 hours. Since there is a range I usually pick the middle of it and go for about 10mg/lb every 12 hours.