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Sclerotic breast cancer metastases in the pelvis. Bone metastases, or metastatic bone disease, is a class of cancer metastases that results from primary tumor invasion to bone. Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare.
Brain metastases are cancer cells that have spread to the brain from primary tumors in other organs in the body (see the image below). Metastatic tumors are among the most common mass lesions in the brain. An estimated 24-45% of all cancer patients in the United States have brain metastases.