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There was also a second physician named Bernard Sachs who recognized the familial nature of the disorder and also observed numerous cases. He witnessed that Tay Sachs disease was most common in the European, Jewish origin. Â· When was Tay Sachs disease discovered?Tay Sachs disease was discovered in the year of 1880.
Tay-Sachs disease-caused by mutations in the HEXA gene. More than 120 mutations that cause Tay-Sachs disease have been identified in the HEXA gene.These mutations reduce or eliminate the activity of the enzyme beta-hexosaminidase A, which prevents the enzyme from breaking down GM2 ganglioside.ay-Sachs disease-caused by mutations in the HEXA gene. More than 120 mutations that cause Tay-Sachs disease have been identified in the HEXA gene.