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The drugâs initial approval noted mild side effects such as vomiting, itching, lethargy and diarrhea. Some 70 million doses of Trifexis have been distributed through 15,000 veterinary clinics, said Elanco spokeswoman Julie Lawless.
The most common side effects reported by patients who took XIFAXAN in this study (occurring in more than 10% of them and at a higher rate than in people taking placebo) were: 1  Swelling (usually in the ankles or lower legs)  Nausea (feeling sick to oneâs stomach)