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How long does it take for an antibiotic to work? Well, it depends upon the type of antibiotic and how serious the infection is. Most antibiotics should work between 24-48 hours. Use the information in this article to decipher whether it is worth waiting or if you should call the doctor, nurse or pharmacist for input. Antibiotics directions and instructions.
1 How long does it take for antibiotics like clarithromycin and amoxicillin stay in your system for? Dr. STEPHEN GIROUX Dr. GIROUX. Just a few days: Antibiotics typically need to be used for 7=14 days to allow your body defenses to overcome an infection.