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7 Hpw long would it take for (1) 81mg of aspirin to be completely out of your system...On for about 1 year. Dr. Venkata Chilakapati Dr. Chilakapati. Aspirin: For small dose of Aspirin elimination half life is 2 to 4.5 hours. So within 24 hours it will be completely eliminated from the body.
You may use aspirin to help treat minor pain. To treat pain, a typical treatment with aspirin is four to eight 81-mg tablets every four hours or one to two 325-mg tablets every four hours. You should never take more than 48 81-mg tablets or 12 325-mg tablets in 24 hours. Your doctor may also prescribe aspirin to help prevent heart attack or stroke.