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Responses (1) takes 24 hours for antibiotic to start working but it could take several days to feel better. You didnt say why you were taking it, it is used alot for urinary tract infections and bladder infections. If this is the case you should drink as much water as you can and this will help also.
Quick Answer. Although an antibiotic's half-life equals half the time it takes to leave an individual's system, it takes five half-lives for the drug to clear a person's system completely, according to HealthTap. Each drug has its own specific half-life, so different antibiotics remain in the system for different lengths of time. Keep Learning.