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A. Much of the initial growth and patterning of the limbs occurs during weeks 4 â 8. Limb buds appear at about 4 weeks and much of the basic structures of the limbs (bones and muscle groups) are established by 8 weeks. After 8 weeks, the limb elements then just increase in size. B. Disruption of growth and/or patterning can result in many possible defects:
Intramembranous ossification occurs during fetal development and does not involve cartilage. Embryologic mesenchymal cells differentiate into osteogenic cells that direct bone growth from spicules to trabeculae, to woven bone, and finally to lamellar bone. Endochondral ossification creates fetal long bones from a cartilage template.