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The drugâs initial approval noted mild side effects such as vomiting, itching, lethargy and diarrhea. Some 70 million doses of Trifexis have been distributed through 15,000 veterinary clinics, said Elanco spokeswoman Julie Lawless.
If your dog is already infected with worms, the manufacturer does warn that your dog may have an increased risk of experiencing side effects such as labored breathing and salivation in addition to the side effects listed above after administration of Trifexis. In clinical trials vomiting was the most common side effect.