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The dose (volume of injection in mL) per month = patient weight (kg) x 15 mg per kg Ã· 100 mg per mL of Synagis. Injection volumes over 1 mL should be. given as a divided dose. â¢ Synagis is supplied as a single-dose vial and does not contain preservatives.
Apparent volume of distribution, V. We can use Equation 5.7.1 to calculate the plasma concentration at any time when we know kel and Cp0. However, usually we don't know Cp0 ahead of time, but we do know the dose. A dose in mass units, maybe in mg. To calculate Cp0 we need to know the volume that the drug is distributed into. That is, the apparent volume of the mixing container, the body. This apparent volume of distribution is not a physiological volume. It won't be lower than blood or plasma volume but for some drugs it can be much larger than body volume.