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CCK plays a variety of roles in digestive processes, including inhibition of food intake, consistent with a role in satiety. In the lingual epithelium, the sensing of a broad spectrum of L-amino acids is accomplished by the heteromeric amino acid (umami) taste receptor (T1R1-T1R3).T1R1 and T1R3 subunits are also expressed in the intestine.A defining characteristic of umami sensing by T1R1-T1R3 is its potentiation by IMP or GMP.ensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion.
The taste buds on top and on the side of the tongue are sensitive to salty and sour tastes. At the base of each taste bud there is a nerve that sends the sensations to the brain. The sense of taste functions in coordination with the sense of smell.