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A. Much of the initial growth and patterning of the limbs occurs during weeks 4 â 8. Limb buds appear at about 4 weeks and much of the basic structures of the limbs (bones and muscle groups) are established by 8 weeks. After 8 weeks, the limb elements then just increase in size. B. Disruption of growth and/or patterning can result in many possible defects:
One in 20 children is born with some hand difference. These can be either major or minor. Some possible differences include missing parts (failure of formation), webbed or fused parts of the hand (failures of separation), extra parts in the hand (duplication), or parts that are larger or smaller than normal. During fetal development, the upper limb is formed between four and eight weeks of pregnancy.