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Responses (1) takes 24 hours for antibiotic to start working but it could take several days to feel better. You didnt say why you were taking it, it is used alot for urinary tract infections and bladder infections. If this is the case you should drink as much water as you can and this will help also.
It means it on this day the medicine starts to weaken the bacteria and it will another 4 days to really them. If no effect yet after taking the med. for 3 or more days, I think you can request the doctor to presecribe a higher dose and higher level of antibiotic. Nitrofurantoin (Macrodantin) is taken for 10 days.