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Hamilton considered Burr an unprincipled rogue. The antagonism between the two came to a head in 1804 when Hamilton thwarted Burr's attempt to gain re-nomination for Vice President as well as his bid to win the governorship of New York. Burr responded by challenging his antagonist to a duel, an invitation Hamilton felt compelled to accept.
Although Hamilton's campaign was probably not the deciding factor, the Burr campaign failed. Burr was crushed in the general election by Morgan Lewis, the Republican candidate, who was supported by George and DeWitt Clinton, powerful New York Republicans.