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How long does it take for an antibiotic to work? Well, it depends upon the type of antibiotic and how serious the infection is. Most antibiotics should work between 24-48 hours. Use the information in this article to decipher whether it is worth waiting or if you should call the doctor, nurse or pharmacist for input. Antibiotics directions and instructions.
I have a bad sinus infection pressure in head and face my doctor gave me amoxicillin antibiotics. How long does it take for the medicine to start working? it&#39;s the 3rd day and I don&#39;t notice anything yet...inus infections can take from a couple of weeks to a month for antibiotics to clear up. It takes the drugs a long time to get into all that pus in your sinuses and to have an effect.