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How long does it take for an antibiotic to work? Well, it depends upon the type of antibiotic and how serious the infection is. Most antibiotics should work between 24-48 hours. Use the information in this article to decipher whether it is worth waiting or if you should call the doctor, nurse or pharmacist for input. Antibiotics directions and instructions.
2 doctors agreed: 24 to 72 hours: Antibiotics can start providing relief anywhere from 24 to 72 hours. If you don't have any relief by 72 hours you should call your dentist as you might need a different antibiotic or an emergency dental treatment. For temporary relief you can take OTC NSAIDs or Tylenol (acetaminophen).