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7 Hpw long would it take for (1) 81mg of aspirin to be completely out of your system...On for about 1 year. Dr. Venkata Chilakapati Dr. Chilakapati. Aspirin: For small dose of Aspirin elimination half life is 2 to 4.5 hours. So within 24 hours it will be completely eliminated from the body.
âYour doctor has most likely told you to take a daily aspirin to help reduce your risk of a heart attack or a stroke. Aspirin works by interfering with your bloodâs ability to form dangerous clots, thus helping to prevent heart attacks and strokes. However, taking aspirin is not without risk.