It is taken to mean heart pain, although chest pain may be due to cramp, spasm in the chest wall muscles, acid flowing back from the stomach, inflammation of the lung surface (pleurisy), or the start of shingles.
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Fra' Girolamo Savonarola was a firebrand preacher, the Mad Monk who briefly turned Florence into a theocracy and church-run police state and who started the original bonfire of the vanities.