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Sclerotic breast cancer metastases in the pelvis. Bone metastases, or metastatic bone disease, is a class of cancer metastases that results from primary tumor invasion to bone. Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare.
Medical Definition of sclerotic. 1  1: being or relating to the sclera the sclerotic layer of the eye. 2  2: of, relating to, or affected with sclerosis a sclerotic blood vessel.