Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
In population ecology: Factors affecting population fluctuation â¦of populations into density-dependent and density-independent factors. Density-independent factors, such as weather and climate, exert their influences on population size regardless of the populationâs density. In contrast, the effects of density-dependent factors intensify as the population increases in size.