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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
Sciatica is leg pain caused by a pinched nerve in the lower back. While the pangs begin in nerve roots located on either side of the lower spine, they afterwards course through the sciatic nerve, which runs the length of each leg from th. A common problem that most people will eventually experience is back pain.