The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Sovereign definition, a monarch; a king, queen, or other supreme ruler. See more.
PARAMOUNT definition - That which is superior. 2. It is usually applied to the highest lord of the fee of lands tenements or hereditaments. F. N. B. 135. Where A lets lands to B and he underlets them to C in this case A is the paramount and B is the mesne landlord. Vide Mesne and 2 Bl. Com. 91; 1 Tho.