Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
An oncogene is a gene that has the potential to cause cancer cancer. Oncogenes were first described as retrovirus-encoded genes that produced tumors in birds and rodents. These genes were then shown to be dominant mutated forms of host genes. (proto-oncogenes) that had been picked up by the retroviruses. Generally they are in the form of a proto-oncogene in the normal cell. Most oncogenes require an additional step, such as mutations in another gene, or environmental factors like non-ionizing or ionizing radiation, or more likely a viral infection, to cause cancer. Many cancer drugs target the proteins encoded by oncogenes.