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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
The pain radiates from the sciatic nerve. The sciatic nerve is the longest nerve in the body and runs from the spinal cord through the hip and down the back of each leg. It is responsible for controlling most of the muscles in your legs.