ICH overview. 1  Guidelines for the investigator. 2  Guidelines for the trial sponsor (industrial, academic) 3  Guidelines for the clinical trial protocol and protocol amendments. 4  Guidelines for the Investigator's brochure.
A mark or sign made by an individual on an instrument or document to signify knowledge, approval, acceptance, or obligation. The term signature is generally understood to mean the signing of a written document with one's own hand. However, it is not critical that a signature actually be written by hand for it to be legally valid. It may, for example, be typewritten, engraved, or stamped.
symÂ·bol. n. 1. a. Something that represents something else by association, resemblance, or convention, especially a material object used to represent something invisible: The lamb is a symbol of innocence.. something used for or regarded as representing something else, esp. a material object representing something immaterial; emblem or sign. 2. a letter, figure, or other conventional mark designating an object, quantity, operation, function, etc., as in mathematics or chemistry.