Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
Onco-, from the Greek onkos, meaning âbulk,â or âmass,â refers to the tumour-causing ability of the oncogene, which is apt, but the term proto-oncogene stresses the potential the gene has to become a malignant force, rather than its integral role as a regulator of cell activity.