The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Sovereign definition, a monarch; a king, queen, or other supreme ruler. See more.
Definition of regent. 1  1 : a person who governs a kingdom in the minority, absence, or disability of the sovereign. 2  2 : a person who rules or reigns : governor. 3  3 : a member of a governing board (as of a state university)