Multidrug-resistant tuberculosis (MDR-TB) is defined as TB that is resistant to both isoniazid [INH] and rifampicin [RMP], two of the first-line drugs used in treating smear-positive pulmonary tuberculosis.ultidrug-Resistant TB (MDR-TB). Extensively drug-resistant tuberculosis (XDR-TB) is defined by the WHO as MDR-TB with additional resistance to any fluoroquinolone (FQ) and to at least one of three injectable second-line anti-tuberculosis drugs used in treatment (capreomycin [CPM], kanamycin [KM] or amikacin [AMK]).
Wither, shrivel imply a shrinking, wilting, and wrinkling. Wither (of plants and flowers) is to dry up, shrink, wilt, fade, whether as a natural process or as the result of exposure to excessive heat or drought: Plants withered in the hot sun. Shrivel, used of thin, flat objects and substances, such as leaves, the skin, etc., means to curl, roll up, become wrinkled: The leaves shrivel in cold weather.
Meaning a cessation of flow in a current or tide is from 1756; that of still stretch of a river is from 1825. Meaning loose part or end (of a rope, sail, etc.) is from 1794; hence figurative senses in take up the slack (1930 figuratively) and slang cut (someone) some slack (1968). Meaning quiet period, lull is from 1851. Slacks loose trousers first recorded 1824, originally military.