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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
Sciatica (sciatic nerve pain) - Symptoms, causes, diagnosis, treatment. Sciatica is a common type of pain caused by compression or irritation of the sciatic nerve. The sciatic nerve is the longest nerve in the body, going from the pelvis, through the buttocks, down the legs to the feet.