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Cholecystokinin definition, a hormone secreted by the upper portion of the intestine that stimulates contraction of the gallbladder and increases secretion of pancreatic juice. See more. Dictionary.com
Cholecystokinin plays a key role in facilitating digestion within the small intestine. It is secreted from mucosal epithelial cells in the first segment of the small intestine (duodenum), and stimulates delivery into the small intestine of digestive enzymes from the pancreas and bile from the gallbladder.holecystokinin is the principle stimulus for delivery of pancreatic enzymes and bile into the small intestine. The most potent stimuli for secretion of cholecystokinin are the presence of partially-digested fats and proteins in the lumen of the duodenum (a particularly potent stimulus is pictured above).