The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Sovereign definition, a monarch; a king, queen, or other supreme ruler. See more.
Regent definition: A regent is a person who rules a country when the king or queen is unable to rule, for... | Meaning, pronunciation, translations and examples English Dictionary | Thesaurus | Translator | Grammar | Scrabble | Blog