Science vs Common Sense. Saxophones are mostly made from brass, which is an alloy mostly of copper and zinc. There are and have been slightly different combinations, and various other metals (e.g. lead) also included. Saxophones are also made from other materials, e.g. copper, bronze, silver and plastic. Various finishes are available: different types of lacquer and metal plating, e.g. silver, gold and nickel.
Due to the many other functions of melanocyte-stimulating hormone besides melanin production, there are likely to be a number of other factors that regulate its production. This means that, unlike most hormones, melanocyte-stimulating hormone release is not thought to be controlled by a direct feedback mechanism.
Melanocytes are melanin-producing neural-crest derived cells located in the bottom layer of the skin's epidermis, the middle layer of the eye, the inner ear, vaginal epithelium, meninges, bones, and heart. Melanin is the pigment primarily responsible for skin color. Once synthesised, melanin is contained in a special organelle called a melanosome and moved along arm-like structures called dendrites, so as to reach the keratinocytes.