The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Sovereign definition, a monarch; a king, queen, or other supreme ruler. See more.
Define kingdom. kingdom synonyms, kingdom pronunciation, kingdom translation, English dictionary definition of kingdom. n. 1. A political or territorial unit ruled by a sovereign. 2. a. The eternal spiritual sovereignty of God or Christ. b. The realm of this sovereignty. 3.