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Cholecystokinin definition, a hormone secreted by the upper portion of the intestine that stimulates contraction of the gallbladder and increases secretion of pancreatic juice. See more. Dictionary.com
Cholecystokinin (CCK)is secreted in response to fats and peptides in the upper small intestines, particularly the duodenum. 1  Actions of CCK include: 2  Secretion of Pancreatic Enzymes. 3  Contraction of Gallbladder. 4  Relaxation of the sphincter of Oddi. 5  increased tension in the pyloric sphincter, inhibiting stomach emptying.