ICH overview. 1  Guidelines for the investigator. 2  Guidelines for the trial sponsor (industrial, academic) 3  Guidelines for the clinical trial protocol and protocol amendments. 4  Guidelines for the Investigator's brochure.
A mark or sign made by an individual on an instrument or document to signify knowledge, approval, acceptance, or obligation. The term signature is generally understood to mean the signing of a written document with one's own hand. However, it is not critical that a signature actually be written by hand for it to be legally valid. It may, for example, be typewritten, engraved, or stamped.
British Dictionary definitions for time signature Expand. noun. 1. (music) a sign usually consisting of two figures, one above the other, the upper figure representing the number of beats per bar and the lower one the time value of each beat. This sign is placed after the key signature at the outset of a piece or section of a piece.