Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Biotic and Abiotic Factors Influenceâ¦ Both abiotic and biotic factors determine both where an organism can live and how much a population can grow. A limiting factor is a factor that restricts the size of a population from reaching its full potential. The amount of food & water in a habitat is an example of a limiting factor. Other factors include