Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Population depends on the rate of growth , as well as external factors. Population is influenced by factors like birth rate & death rate . Birth rate (Natality)- This refers to the number of newborns in a region at a given time. Death rate (Mortality) - This refers to the number of deaths in a region at a given time.