Multidrug-resistant tuberculosis (MDR-TB) is defined as TB that is resistant to both isoniazid [INH] and rifampicin [RMP], two of the first-line drugs used in treating smear-positive pulmonary tuberculosis.ultidrug-Resistant TB (MDR-TB). Extensively drug-resistant tuberculosis (XDR-TB) is defined by the WHO as MDR-TB with additional resistance to any fluoroquinolone (FQ) and to at least one of three injectable second-line anti-tuberculosis drugs used in treatment (capreomycin [CPM], kanamycin [KM] or amikacin [AMK]).
Wither, shrivel imply a shrinking, wilting, and wrinkling. Wither (of plants and flowers) is to dry up, shrink, wilt, fade, whether as a natural process or as the result of exposure to excessive heat or drought: Plants withered in the hot sun. Shrivel, used of thin, flat objects and substances, such as leaves, the skin, etc., means to curl, roll up, become wrinkled: The leaves shrivel in cold weather.
Meaning to walk lamely is from c.1400. Transitive sense of tie the legs (of an animal) first recorded 1831, probably an alteration of 16c. hopple, cognate with Flemish hoppelen to rock, jump, which also is related to Dutch hobbelen. Sense of hamper, hinder is c.1870. Related: Hobbled; hobbling. The noun is 1727, from the verb.