Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Two density-independent limiting factors include temperature and weather. These two factors do not rely on the size or density of a certain population. They affect all organisms (in a population) equally.f the population density in the ecosystem were to increase, competition over these cacti would increase, making this a density-dependent limiting factor. Only a certain density of Cactus Wren can be supported in an ecosystem. Another example of a density-dependent limiting factor is disease.