Laying Out the French Drain. The easiest method when laying out the location for the drain is to install it along the walls that meet in the corner where the sump pit is located. This provides an ideal location for the drain to direct the water, as a sump pump can pump the water out of the pit as it fills.aying Out the French Drain. The easiest method when laying out the location for the drain is to install it along the walls that meet in the corner where the sump pit is located. This provides an ideal location for the drain to direct the water, as a sump pump can pump the water out of the pit as it fills.
School of Medicine, Family Medicine answered. If you're on blood pressure medication, you should avoid eating grapefruit. The reason why is that grapefruit is very acidic and breaks down certain medications much faster. For some people, this causes them to absorb too much of the medicine and for others, not enough. Blood pressure medications that are affected by grapefruit juice include calcium channel blockers such as nifedipine.
One or more substances in grapefruit and grapefruit juice block the action of an enzyme called cytochrome P-450 3A4 (CYP3A4). This enzyme breaks down a wide array of medications, including atorvastatin (Lipitor). (For an extensive list of drugs affected by grapefruit juice, visit health.harvard.edu/165.) Knocking CYP3A4 out of action means higher blood levels of these medications. One glass of grapefruit juice, or eating half a grapefruit, is enough to suppress CYP3A4 activity by half, and the effect lasts up to 24 hours.