Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Factors that affect population size and growth. Tejvan Pettinger April 28, 2008 development. Readers question: Explain the main factors which affect population size. Economic Development. Countries who are in the early stages of economic development tend to have higher rates of population growth.