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In Type 1 diabetes, previously called insulin-dependent diabetes mellitus (IDDM for short) and juvenile-onset diabetes, the body may either produce insulin in very small amounts or it may not produce insulin at all.
Type 1 diabetes mellitus is characterized by loss of the insulin-producing beta cells of the islets of Langerhans in the pancreas, leading to insulin deficiency. This type can be further classified as immune-mediated or idiopathic. Type 2 DM begins with insulin resistance, a condition in which cells fail to respond to insulin properly. 2  As the disease progresses a lack of insulin may also develop. 3  This form was previously referred to as non insulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes.