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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
1 The sciatic nerve is the largest nerve in the body. 2  Sciatica pain is typically felt from the low back to behind the thigh and radiating down below the knee.  Treatments for sciatica depend on the underlying cause and the severity of the pain.