Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Density-dependant factors-. Factors that basically depend on how much of a population lives in an area. For instance: Food, if the amount of species goes way up, then the amount of food goes down. Density-independant factors-. These are factors that affect a population, but are not affected by the population itself.