Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
The dotted line shows what the relationship would look like if predator and prey increased proportionately. The size differential between predator and prey was often less than 20 mm. The effects of predation on both predator and prey populations change as prey densities vary. Prey preference of lingcod (Ophiodon elongatus), a top marine predator: implications for ecosystem-based fisheries management. Average speeds of predator and prey populations before and after a one-round simulation.