ICH overview. 1  Guidelines for the investigator. 2  Guidelines for the trial sponsor (industrial, academic) 3  Guidelines for the clinical trial protocol and protocol amendments. 4  Guidelines for the Investigator's brochure.
A mark or sign made by an individual on an instrument or document to signify knowledge, approval, acceptance, or obligation. The term signature is generally understood to mean the signing of a written document with one's own hand. However, it is not critical that a signature actually be written by hand for it to be legally valid. It may, for example, be typewritten, engraved, or stamped.
In the United States and Canada, a medallion signature guarantee is a special signature guarantee for the transfer of securities. It is a guarantee by the transferring financial institution that the signature is genuine and the financial institution accepts liability for any forgery. Signature guarantees protect shareholders by preventing unauthorized transfers and possible investor losses.