Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
Oncogenes are damaged versions of normal genes called proto-oncogenes proto-oncogenesA normal gene involved in the control of cell growth and division that can mutate (change) and become an oncogene. Mutations can be inherited or caused by exposure to a carcinogen (a substance that causes cancer) in the environment. .