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The sciatic nerve is the largest single nerve in the human body; it runs from each side of the lower spine through deep in the buttock into the back of the thigh and all the way down to the foot. It serves a vital role in connecting the spinal cord with the leg and foot muscles.
1 Sciatica is nerve pain from irritation of the sciatic nerve. 2  The sciatic nerve is the largest nerve in the body. 3  Sciatica pain is typically felt from the low back to behind the thigh and radiating down below the knee. 4  Treatments for sciatica depend on the underlying cause and the severity of the pain. The sciatic nerve is the largest nerve in the body. 2  Sciatica pain is typically felt from the low back to behind the thigh and radiating down below the knee. 3  Treatments for sciatica depend on the underlying cause and the severity of the pain.