Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
The oncogene is a mutated form of a so-called protooncogene, which is a gene that normally causes high cell division rates where it is needed, such as in the fetus or in a wound where cells must be replaced. The abnormal activation of such a gene in time or place causes cancer.