ICH overview. 1  Guidelines for the investigator. 2  Guidelines for the trial sponsor (industrial, academic) 3  Guidelines for the clinical trial protocol and protocol amendments. 4  Guidelines for the Investigator's brochure.
A mark or sign made by an individual on an instrument or document to signify knowledge, approval, acceptance, or obligation. The term signature is generally understood to mean the signing of a written document with one's own hand. However, it is not critical that a signature actually be written by hand for it to be legally valid. It may, for example, be typewritten, engraved, or stamped.
A digital signature is an authentication mechanism that enables the creator of the message to attach a code that acts as a signature. Formally, a digital signature scheme is a triple of probabilistic polynomial time algorithms, (G, S, V), satisfying: G (key-generator) generates a public key, pk, and a corresponding private key, sk, on input 1, where n is the security parameter.