ICH overview. 1  Guidelines for the investigator. 2  Guidelines for the trial sponsor (industrial, academic) 3  Guidelines for the clinical trial protocol and protocol amendments. 4  Guidelines for the Investigator's brochure.
A mark or sign made by an individual on an instrument or document to signify knowledge, approval, acceptance, or obligation. The term signature is generally understood to mean the signing of a written document with one's own hand. However, it is not critical that a signature actually be written by hand for it to be legally valid. It may, for example, be typewritten, engraved, or stamped.
You can also say that someone signs their name. Sign your name in the book each time you use the photocopier. 2. 'signature'. However, when you write your name, you do not refer to what you write as your 'sign'. You call it your signature. Nino scrawled his signature on the bottom of the slip. ...ignature. n. 1. the name of a person or a mark or sign representing his name, marked by himself or by an authorized deputy. 2. the act of signing one's name. 3. a. a distinctive mark, characteristic, etc, that identifies a person or thing. b. (as modifier): a signature fragrance.