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Symptoms of bile duct cancer. There aren't usually any symptoms of bile duct cancer until it grows large enough to block the bile ducts. This can cause: yellowing of the skin and whites of the eyes (jaundice) itchy skin. pale stools and dark urine. loss of appetite and weight loss. persistent tiredness and feeling unwell.
Most of these are adenocarcinomas, which are cancers that start in glandular cells. Bile duct adenocarcinomas develop from the mucous gland cells that line the inside of the duct. Bile duct cancer can affect your body in many ways. As part of the digestive system, bile ducts help digest food properly. If cancer spreads to the liver, the chemical balance of the body will be disturbed. Researchers do not know the exact cause of most bile duct cancers.