the condition of being ignorant; the want of knowledge in general, or in relation to a particular subject; the state of being uneducated or uninformed. Ignorance (noun). a willful neglect or refusal to acquire knowledge which one may acquire and it is his duty to have. Origin: [F., fr.
Monoamine oxidase inhibitors (MAOIs) are a class of medication used to treat depression. They were introduced in the 1950s as the first drugs for depression. Today, theyâre less popular than other depression medications, but some people benefit from their use.
MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B.he early MAOIs covalently bound to the monoamine oxidase enzymes, thus inhibiting them irreversibly; the bound enzyme could not function and thus enzyme activity was blocked until the cell made new enzymes. The enzymes turn over approximately every two weeks.