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Some of the less common causes of Tongue mass may include: 1  Congenital lipomatoid mass. 2  Recurrent oral herpes simplex virus infection. 3  Haemangioma. Lingual thyroid.  Thyroglossal duct 1  cyst. Pleomorphic adenoma.
Hereâs a look at some common causes. 1  Medications. 2  Many cases of a swollen tongue are the result of a reaction to a medication such as an ACE inhibitor, used to treat high blood pressure, or an NSAID, or non-steroidal anti-inflammatory drug, such as aspirin, ibuprofen [Advil, Motrin], or naproxen [Aleve, Naprosyn]. In addition to allergic reactions to medications, allergic reactions to other substances â such as foods or bee stings â can cause swelling. 2  In food allergies and bee sting allergies, the tongue can swell, but it is less common to have a swollen tongue than it is to have a swollen throat or lips. 3  Infection.