Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
In summary, transformation is the process in which the genetic makeup of a cell is changed by introduction of DNA from the surrounding environment. To make bacterial cells competent for transformation, the cells are incubated in chilled calcium chloride.