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There are a few differences between the nucleus and nucleolus. To better differentiate the two parts of the cell, we should consider the functions, structures, and other features of these cellular organelles. Basically, the nucleolus is just a part of the nucleus.The nucleus is the main part of the cell while the nucleolus is part of the nucleus itself. The nucleus is a membrane-bound organelle that is found in multi-celled organisms or eukaryotes.This membrane that encloses the nucleus has two parts. The parts of the membrane are the inner and outer cellular membrane..The nucleus is membrane bound while the nucleolus is non-membrane bound. 3.The nucleus contains DNA while the nucleolus contains RNA. 4.The nucleus has the chromosomes and cellular membranes while the RNA has the fibrillar centers, dense fibrillar centers, and the granular component.
The Nucleolus. The nucleolus is a prominent sub-nuclear structure that is not bound by a membrane and resides within the nuclear matrix. Though known to exist since the eighteenth century, the primary function of the nucleolus was not discovered until the 1960s.t the onset of mitosis, the single nucleolus present in a human cell disappears, and subsequent to the process, the formation of the new nucleolus, which is created from the ten smaller nucleolus-like structures that develop from the NORs, can be observed.