Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
The factors that control the increase in abundance of a species during succession may be determined mainly by seed production and dispersal, micro climate; landscape structure (habitat patch size and distance to outside seed sources); Bulk density, pH, soil texture (sand and clay).