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The system exerts its influence via release or inhibition of vasopressin (antidiuretic hormone, ADH) which acts on the kidney to decrease water excretion. Deficiency of ADH is usually due to hypothalamic-neurohypophyseal lesions (central diabetes insipidus) or insensitivity of the kidney to ADH (nephrogenic diabetes insipidus). These patients, if untreated, have the predictable result of dehydration, hyperosmolality, hypovolemia, and eventual death in severe cases.
Addisonâs disease. An illness caused by the failure of the adrenal glands to secrete enough adrenal hormones. Adrenal glands. Two glands, each located above a kidney, that secrete cortisol and other essential hormones.Aldosterone. A hormone made by the adrenal glands that regulates salt, potassium, and water in the body.his information was developed by the patient care staff of the NIH Clinical Center to help patients with. adrenal insufficiency (AI) understand their condition and how to take care of it. It explains what causes adrenal. insufficiency and how it can be controlled.