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Apremilast (brand name Otezla, by Celgene) is a drug for the treatment of certain types of psoriasis and psoriatic arthritis. It may also be useful for other immune system related inflammatory diseases.
Thus, an inhibitor of PDE4 results in an increase in cAMP, which is similar to CF101's mechanism of action (discussed below). Otezla(R) was approved for the treatment of psoriatic arthritis in March 2014, and then for the treatment of psoriasis in September 2014. The drug was approved for the treatment of psoriasis based on two Phase 3 clinical trials involving over 1,200 patients.