Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Factors Affecting Population Growth 70. POPULATION GROWTH. According to the Malthusian Principle , the rate of growth expressed in mathematical terms is: dN/dt = rN (1) where the first term ( dN/dt ) indicates a change in the population density N for every change in time t; and r is the.