ICH overview. 1  Guidelines for the investigator. 2  Guidelines for the trial sponsor (industrial, academic) 3  Guidelines for the clinical trial protocol and protocol amendments. 4  Guidelines for the Investigator's brochure.
A mark or sign made by an individual on an instrument or document to signify knowledge, approval, acceptance, or obligation. The term signature is generally understood to mean the signing of a written document with one's own hand. However, it is not critical that a signature actually be written by hand for it to be legally valid. It may, for example, be typewritten, engraved, or stamped.
Method signature. The signature of a method consists of its name and the types of its parameters (enclosed in parentheses and separated by commas). For example, the signature of the method declared near the beginning of this webpage is. isLess(int). In Java, the methods in a class must have different signatures.