ICH overview. 1  Guidelines for the investigator. 2  Guidelines for the trial sponsor (industrial, academic) 3  Guidelines for the clinical trial protocol and protocol amendments. 4  Guidelines for the Investigator's brochure.
A mark or sign made by an individual on an instrument or document to signify knowledge, approval, acceptance, or obligation. The term signature is generally understood to mean the signing of a written document with one's own hand. However, it is not critical that a signature actually be written by hand for it to be legally valid. It may, for example, be typewritten, engraved, or stamped.
Painterly work gives the impression of an artist taking pleasure in the physical nature of the paint itself. All very well put Barry, I need to remember that one and your aforementioned statement! Painterly leaves a signature, a style that conveys confidence with the resulting pleasure of every brush stroke. The definition of signature is something that is recognizable. A photo-realistic painting has no signature, it could be anybody that has mastered their techinque in copying if you will.