Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
Transformation In genetics, the transfer of genes by one organism taking up DNA belonging to another organism of the same or different species. Transgenic organism An organism created by genetic engineering, in which one or more foreign genes have been incorporated into its genome.