Symptoms of sciatica originating at this level of the lower back may include: pain and/or numbness at the top of the foot, particularly in the web between the great toe (big toe) and the second toe. 1  See All about the L4-L5 Spinal Segment. 2  Sciatica from S1 nerve root.
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(March 2014). An institutional review board (IRB), also known as an independent ethics committee (IEC), ethical review board (ERB), or research ethics board (REB), is a committee that has been formally designated to approve, monitor, and review biomedical and behavioral research involving humans.