Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
Oncogenes are mutated genes whose PRESENCE can stimulate the development of cancer. When oncogenes arise in normal cells, they can contribute to the development of cancer by telling cells to make proteins that stimulate excessive cell growth and division. Oncogenes are gain of function genes. few important tumor-suppressor genes: 1  p53: a transcription factor that regulates cell division and cell death. 2  Rb: alters the activity of transcription factors and therefore controls cell division. 3  APC: controls the availability of a transcription factor.