Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
  A proto-oncogene is normally converted to an oncogene by mutation of the gene that encodes the proto-oncogene. Often, this leads to de-regulation of the proto-oncogene â¦ s activity and typically abarrent signal transduction in the cell, which may lead to cellular transformation.1 person found this useful.n these cases, the proto-oncogene product is continually in an on state, which may constantly stimulate the cell to divide. When a proto-oncogene is mutated or aberrantly expressed, and contributes to the development of cancer, it is known as an oncogene.