Symptoms of sciatica originating at this level of the lower back may include: pain and/or numbness at the top of the foot, particularly in the web between the great toe (big toe) and the second toe. 1  See All about the L4-L5 Spinal Segment. 2  Sciatica from S1 nerve root.
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(March 2014). An institutional review board (IRB), also known as an independent ethics committee (IEC), ethical review board (ERB), or research ethics board (REB), is a committee that has been formally designated to approve, monitor, and review biomedical and behavioral research involving humans.n the United States, IRBs are governed by Title 45 Code of Federal Regulations Part 46. These regulations define the rules and responsibilities for institutional review, which is required for all research that receives support, directly or indirectly, from the United States federal government.