ICH overview. 1  Guidelines for the investigator. 2  Guidelines for the trial sponsor (industrial, academic) 3  Guidelines for the clinical trial protocol and protocol amendments. 4  Guidelines for the Investigator's brochure.
A mark or sign made by an individual on an instrument or document to signify knowledge, approval, acceptance, or obligation. The term signature is generally understood to mean the signing of a written document with one's own hand. However, it is not critical that a signature actually be written by hand for it to be legally valid. It may, for example, be typewritten, engraved, or stamped.
1530s, a kind of document in Scottish law, from Middle French signature (16c.) or directly from Medieval Latin signatura signature, a rescript, in classical Latin the matrix of a seal, from signatus, past participle of signare to mark with a stamp, sign (see sign (v.)).