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An excitatory postsynaptic potential (EPSP) is a temporary depolarization of postsynaptic membrane potential caused by the flow of positively charged ions into the postsynaptic cell. A postsynaptic potential is defined as excitatory if it makes it easier for the neuron to fire an action potential. They are the opposite of inhibitory postsynaptic potentials (IPSPs), which usually result from the flow of negative ions into the cell. An Inhibitory Postsynaptic Potential (commonly abbreviated as IPSP) is the change in membrane voltage of a postsynaptic neuron which results from synaptic activation of inhibitory neurotransmitter receptors.