If the perforated bowel is repaired through gastrointestinal resection and anastomosis, whereby the perforated, damaged section of the bowel is removed and the remaining sections reattached, it can lead to complications. Leakage at the repair site can lead to infection, and scaring at the repair site can lead to restricted interior flow.
Humanitarian use device. A Humanitarian use device (HUD), as defined by the Food and Drug Administration (FDA), is a device intended to benefit patients by treating or diagnosing a disease or condition that affects or is manifested in fewer than 4,000 individuals per year in the United States.
The HandiHaler device is an inhalation device used to inhale the dry powder contained in the SPIRIVA capsule. The dry powder is delivered from the HandiHaler device at flow rates as low as 20 L/min. Under standardized in vitro testing, the HandiHaler device delivers a mean of 10.4 mcg tiotropium when tested at a flow rate of 39 L/min for 3.1 seconds (2L total).