The two men had become the first known humans to summit the world's tallest mountain on May 29, 1953 (time line of Everest milestones). Returning to base camp, Hillary had irreverently remarked, We knocked the bastard off..
After repeated administration of metformin hydrochloride extended-release tablets, metformin did not accumulate in plasma. Within-subject variability in Cmax and AUC of metformin from metformin hydrochloride extended-release tablets is comparable to that with metformin hydrochloride tablets.
Extended-release drug products. A dosage form that allows at least a twofold reduction in dosage frequency as compared to that drug presented as an immediate-release (conventional) dosage form. Examples of extended-release dosage forms include controlled-release, sustained-release, and long-acting drug products. Delayed-release drug products. A dosage form that releases a discrete portion or portions of drug at a time other than promptly after administration.