ICH overview. 1  Guidelines for the investigator. 2  Guidelines for the trial sponsor (industrial, academic) 3  Guidelines for the clinical trial protocol and protocol amendments. 4  Guidelines for the Investigator's brochure.
A mark or sign made by an individual on an instrument or document to signify knowledge, approval, acceptance, or obligation. The term signature is generally understood to mean the signing of a written document with one's own hand. However, it is not critical that a signature actually be written by hand for it to be legally valid. It may, for example, be typewritten, engraved, or stamped.
A handwritten but digitally captured signature made on a touch device, such as a tablet or smartphone (sometimes referred to as a âdynamic signatureâ) What is a digital signature? Sometimes referred to as a cryptographic signature, a digital signature is considered the most âsecureâ type of electronic signature. It includes a certificate of authority, such as a Windows certificate, to ensure the validity of the signatory (the signatureâs author and owner). The parties on either side of a digital signature can also detect whether the signed document was altered or changed in any way that would invalidate it.