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Cholecystokinin definition, a hormone secreted by the upper portion of the intestine that stimulates contraction of the gallbladder and increases secretion of pancreatic juice. See more. Dictionary.com
Cholecystokinin also: 1  stimulates the secretion of bile salts into the biliary system. 2  stimulates the secretion of pancreatic enzymes. 3  induces satiety (lack of hunger) 4  modulates hormones and neuropeptides.