Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). Spironolactone should be used only in those conditions described under INDICATIONS AND USAGE. Unnecessary use of this drug should be avoided.
The density of a population can be regulated by various factors, including biotic and abiotic factors and population size. Density-dependent regulation can be affected by factors that affect birth and death rates such as competition and predation.
Two density-dependent limiting factors include competition and disease. Both of these factors rely on the size and density of a population because it creates conflict over limited resources (competition) and the more dense a population is, the easier it is for pathogens to spread and infect many individuals (disease).f the population density in the ecosystem were to increase, competition over these cacti would increase, making this a density-dependent limiting factor. Only a certain density of Cactus Wren can be supported in an ecosystem. Another example of a density-dependent limiting factor is disease.