Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
The normal forms of these genes are called proto-oncogenes, while the mutated, cancer-causing forms are called oncogenes. In contrast to tumor suppressor genes, which put the brakes on cell proliferation, oncogenes actively promote proliferation (analogous to the gas petal of the cell cycle).