The two men had become the first known humans to summit the world's tallest mountain on May 29, 1953 (time line of Everest milestones). Returning to base camp, Hillary had irreverently remarked, We knocked the bastard off..
After repeated administration of metformin hydrochloride extended-release tablets, metformin did not accumulate in plasma. Within-subject variability in Cmax and AUC of metformin from metformin hydrochloride extended-release tablets is comparable to that with metformin hydrochloride tablets.
Responses (1) Extended release means the pill is formulated so that the drug is released slowly over time. This has the advantage of taking pills less often. Also means that there may be fewer side effects as the levels of the of drug in the body are more consistent in extended release formulations.