Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
Malignant transformation of solitary enchondroma is extremely rare (1%). In the context of enchondromatosis ( Ollier disease, Maffucci syndrome) the risk of malignant transformation is increased up to 35%.