Symptoms of sciatica originating at this level of the lower back may include: pain and/or numbness at the top of the foot, particularly in the web between the great toe (big toe) and the second toe. 1  See All about the L4-L5 Spinal Segment. 2  Sciatica from S1 nerve root.
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You are here. What is the Institutional Review Board (IRB)? The Institutional Review Board (IRB) is an administrative body established to protect the rights and welfare of human research subjects recruited to participate in research activities conducted under the auspices of the institution with which it is affiliated.