Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat-called an arrhythmia-that causes a severe decrease in the pumping function of the heart.
The abnormal FIG-ROS fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Chromosomal inversion s: reversing the orientation of a chromosomal segment.
oncogenes are the gene causing cancer generally firstly they are in the form of proto-oncogene in the normal cell but some reagent like non-ionizing or ionizing radiation activate it into the oncogenes then the cell mutate and lead rise to the cancer cell eg. proto-oncogene ---> oncogene (in presence of UV-rays or GAMMA -rays)