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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Glucagon is secreted to maintain glucose levels in the bloodstream when fasting and to raise very low glucose levels. Glucagon is a hormone that is involved in controlling blood sugar (glucose) levels. It is secreted into the bloodstream by the alpha cells, found in the islets of Langerhans, in the pancreas. The glucagon-secreting alpha cells surround a core of insulin-secreting beta cells, which reflects the close relationship between the two hormones.