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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
This will cause scarring in the bone marrow that is very extensive and leads to anemia that is severe, fatigue, and weakness as well as in some cases an enlarged liver and spleen. Myelofibrosis is actually a type of chronic leukemia â cancer that upsets the tissues that are blood-forming in the body. This disorder can happen on its own (primary myelofibrosis) or it may occur because of other disorders of the bone marrow (secondary myelofibrosis). Numerous individuals with myelofibrosis progressively get worse and certain ones can eventually develop a much more serious form of leukemia.