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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
Myelofibrosis is a rare bone marrow cancer in which the. marrow is replaced by fibrous (scar) tissue. Bone marrow is. the soft, fatty tissue inside the bones. The cancer develops. when a mutation occurs in the DNA of a single. hematopoietic (blood-forming) stem cell. Blood stem cells.