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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Introduction & background. Ghrelin, also known as the appetite or hunger hormone, is the first hormone demonstrated to stimulate food intake or appetite in humans. In simple words, this hormone tells your brain that your body has to be fed and you are feeling hungry.