As folate is vital in the first trimester of pregnancy for healthy fetal development, the use of antifolates is strongly contraindicated in pregnancy and carries significant teratogenic risk. Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency.
Cause of Adult Mumps. Adult mumps is caused by an infection with the mumps virus, which is found worldwide. The mumps virus is an RNA (ribonucleic acid) virus from the family Paramyxovirus of the genus Rubulavirus. The mumps virus only infects humans.
Mumps is an infection caused by a virus. It mainly affects the salivary glands but sometimes other parts of the body are affected. Mumps normally affects children, but can occur at any age.Mumps is now rare in the UK as children are routinely immunised against mumps. The testicles (testes) are sometimes affected. 2  One testicle (testis) may become inflamed, swollen, and painful for about a week. 3  This is uncommon in young children. 4  However, about 1 in 4 males who get mumps over the age of 12 years will develop a painful swollen testis. 5  Occasionally, both testes are affected.