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The bottom there is 10,924 meters (35,840 feet) below sea level. If Mount Everest, the highest mountain on Earth, were placed at this location it would be covered by over one mile of water.
Lack of oxygen is one of the major challenges posed by Everest. The oxygen levels at the top are only a third of what they are at sea level. Humans cannot survive for any length of time at elevation above 26,000 feet (8000 m), which on Everest is known as the death zone.