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Orchitis (or-KIE-tis) is an inflammation of one or both testicles. It is usually caused by a bacterial infection or by the mumps virus. Bacterial orchitis can be caused by sexually transmitted infections (STIs), particularly gonorrhea or chlamydia. Bacterial orchitis often results from epididymitis, an inflammation of the coiled tube (epididymis) at the back of the testicle that stores and carries sperm. In that case, it's called epididymo-orchitis.
With orchitis, you may have a rapid onset of pain in one or both testicles that may spread to the groin. 1  One or both of your testicles may appear tender, swollen, and red or purple. 2  You might have a heavy feeling in the swollen testicle.  You might see blood in your semen.