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Thick blood is caused by a variety of conditions, such as heavy proteins in the blood, too much blood in circulation or a blood clot system imbalance, according to Southeastern Medical Oncology Center. Diseases such as cancer and lupus can also lead to thick blood. Continue Reading.
Conditions that can trigger excessive blood clotting in the heart and brain: 1  Atherosclerosis is a disease in which a waxy substance called plaque builds up inside your arteries. 2  Vasculitis is a disorder that causes the bodyâs blood vessels to become inflamed.