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1 Insulin sensitivity is increased, so your cells are better able to use any available insulin to take up glucose during and after activity. 2  When your muscles contract during activity, it stimulates another mechanism that is completely separate of insulin.
By contrast, polyunsaturated fatty acids (omega-3) increase insulin sensitivity. Medications such as metformin, exenatide and a class of drugs called the thiazolidinediones can help improve insulin resistance. These are approved in the treatment of type 2 diabetes but not for the treatment of insulin resistance alone. Growth hormone replacement therapy, on the other hand, can be used when insulin resistance exists alone without type 2 diabetes. Magnesium supplements administered daily can restore depleted levels of magnesium which can also improve the glucose uptake from blood mediated by insulin.