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biology of prions Dr. Stanley Prusiner coined the term prion in 1982, which he defined as a small infectious pathogen containing protein but apparently lacking nucleic acid . The prion protein (PrP) is the critical component of these agents and may, in fact, be its exclusive constituent.
The protein that prions are made of (PrP) is found throughout the body, even in healthy people and animals. However, PrP found in infectious material has a different structure and is resistant to proteases, the enzymes in the body that can normally break down proteins.ll known prion diseases in mammals affect the structure of the brain or other neural tissue and all are currently untreatable and universally fatal. Prions are not considered living organisms because they are misfolded protein molecules which may propagate by transmitting a misfolded protein state.