Metastatic bone disease is a serious condition in which cancer has migrated from another part of the body, such as the lung, breast, prostate, thyroid, or kidney into one or more bones of the skeleton. Metastatic bone disease is not the same as cancer that originates in the bone, such as sarcoma.
In this article. Dupuytrenâs contracture, also known as Dupuytrenâs disease, is a hand deformity that causes the tissue beneath the surface of the hand to thicken and contract. Evidence of Dupuytrenâs usually begins with a thickening of the palm.
In a case of Dupuytren's contracture, collagen accumulates in the palmar fascia of the hands, so that the fingers cannot be straightened. A similar phenomenon occurs in Peyronie's disease, a contracture of the penis. Collagenase clostridium histolyticum injection for Dupuytren's contracture. In February 2011, the European Commission's Committee for Medicinal Products for Human Use approved the product for the treatment of Dupuytren's contracture in adults with a palpable cord by 'properly trained' doctors.