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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
A problem with one of your genes causes you to make stem cells that donât work the way they should. These are the cells that make blood in your bone marrow. With myelofibrosis (MF) they get inflamed, and scar tissue forms. About 90% of people who get this kind of cancer have a change in one of three genes: JAK2, CALR, or MPL. These genes change during your lifetime, but we donât know why.