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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
Fibrosis is the formation of excessive fibrous connective tissue in place of healthy tissue. The disease myelofibrosis - or MF - (one of the myeloproliferative neoplasms) is characterized by fibrosis in the bone marrow. This reduces the bone marrow's ability to produce blood cells. Prognosis for sufferers of myelofibrosis varies. The prognosis of myelofibrosis is different for every patient.