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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
When the bone marrow is scarred, it cannot make enough blood cells. Anemia, bleeding problems, and a higher risk of infections may occur. As a result, the liver and spleen try to make some of these blood cells. This causes these organs to swell. The cause of myelofibrosis is unknown.