Chemistry and Pharmacology: Fentanyl is about 100 times more potent than morphine as an analgesic. It is a Âµ-opioid receptor agonist with high lipid solubility and a rapid onset and short duration of effects. Fentanyl rapidly crosses the blood-brain barrier. It is similar to other -Âµopioid receptor agonists (like morphine or oxycodone) in its pharmacological effects and produces analgesia, sedation, respiratory depression, nausea, and vomiting. Fentanyl appears to produce muscle rigidity with greater frequency than other opioids.
Babylonia, Iraq. c. 1750 BCE. Hammurabi, also spelled Hammurapi (born , Babylon [now in Iraq]âdied c. 1750 bce) sixth and best-known ruler of the 1st (Amorite) dynasty of Babylon (reigning c. 1792â1750 bce), noted for his surviving set of laws, once considered the oldest promulgation of laws in human history. See Hammurabi, Code of.
During the last week of April 1945, Subhas Chandra Bose along with his senior Indian National Army (INA) officers, several hundred enlisted INA men, and one hundred women from the INA's Rani of Jhansi Regiment left Rangoon by road for Moulmein in Burma.n 23 August 1945, the Japanese news agency Do Trzei announced the death of Bose and Shidea. On 7 September a Japanese officer, Lieutenant Tatsuo Hayashida, carried Bose's ashes to Tokyo, and the following morning they were handed to the president of the Tokyo Indian Independence League, Rama Murti.