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Histones are alkaline (basic pH) proteins. They are found inside the nucleus of eukaryotic cells. Their purpose is to package DNA into structural units called nucleosomes.They are the main proteins in chromatin (a combination of DNA and protein), which makes up the contents of a cell nucleus.2A, H2B, H3, and H4 are the core histones, and H1 and H5 are the linker histones. The core histones form the center of the nucleosome, hence the term 'core'. The linker histones are found at the entrance and exit sites of the nucleosome and lock the DNA in place, hence the term 'linker'.
Types of histones. Each octamer has two pairs of different histone proteins: H2A, H2B, H3 and H4. They are arranged as a pair of H2A-H2B dimers, and an (H3)2(H4)2 tetramer. There is an additional type of histone, the linker histone H1, which is present in condensed DNA.istone packaging of DNA is a ubiquitous mechanism throughout species, and the structures of histones are highly conserved. They contain high amounts of two positively charged amino acids: lysine and arginine. Of course, there are some differences between the types of histone proteins: 1  H2A and H2B contain more lysine;