Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which abnormal cysts develop and grow in the kidneys. Cystic disorders can express themselves at any point, infancy, childhood, or adulthood.The disease occurs in humans and some other animals.PKD is characterized by the presence of multiple cysts (hence, polycystic) typically in both kidneys; however, 17% of cases initially present with observable disease in one kidney, with most cases progressing to bilateral disease in adulthood.utosomal dominant polycystic kidney disease (ADPKD) is the most common of all the inherited cystic kidney diseases with an incidence of 1:500 live births. Studies show that 10% of end-stage kidney disease (ESKD) patients being treated with dialysis in Europe and the U.S. were initially diagnosed and treated for ADPKD.
The Sacramento River is the largest river and watershed system in California (by discharge, it is the second largest U.S. river draining into the Pacific, after the Columbia River).
California's diverse geography ranges from the Sierra Nevada in the east to the Pacific Coast in the west, from the redwood â Douglas fir forests of the northwest, to the Mojave Desert areas in the southeast.he two most prominent rivers within California are the Sacramento River and the San Joaquin River, which drain the Central Valley and the west slope of the Sierra Nevada and flow to the Pacific Ocean through San Francisco Bay.