3. a mental representation of something: she's got a good idea of the layout of the factory. 4. the characterization of something in general terms; concept: the idea of a square circle is self-contradictory. 5. an individual's conception of something: his idea of honesty is not the same as yours and mine. 6. the belief that something is the case: he has the idea that what he's doing is right. 7. a scheme, intention, plan, etc: here's my idea for the sales campaign. 8. a vague notion or indication; inkling: he had no idea of what life would be like in Africa.
Since DNA replication moves along the parent strand in the 5' to 3' direction, replication can occur very easily on the leading strand. As seen in, the nucleotides are added in the 5' to 3' direction. Triggered by RNA primase, which adds the first nucleotide to the nascent chain, the DNA polymerase simply sits near the replication fork, moving as the fork does, adding nucleotides one after the other, preserving the proper anti-parallel orientation.
B. DNA Replication in Bacteria. DNA Replication in Bacteria. In general, DNA is replicated by uncoiling of the helix, strand separation by breaking of the hydrogen bonds between the complementary strands, and synthesis of two new strands by complementary base pairing. Replication begins at a specific site in the DNA called the origin of replication (oriC). DNA replication is bidirectional from the origin of replication. To begin DNA replication, unwinding enzymes called DNA helicases cause short segments of the two parent DNA strands to unwind and separate from one another at the origin of replication to form two Y-shaped replication forks. These replication forks are the actual site of DNA copying (see Fig. 4).