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Lack of evidence: There is little evidence to suggest that low dose Seroquel is an effective treatment for insomnia. Despite the drugâs perception of being an effective treatment for insomnia, there is minimal evidence in support of these claims.
1 SEROQUEL XR is approved to work alone to treat 3 types of episodes that may occur in bipolar disorder (depressive lows, manic highs, and mixed episodes of highs and lows), for the short term.  SEROQUEL XR is also approved for long-term maintenance treatment of bipolar I disorder when added to lithium or divalproex.