It does not take a lot of leaves to make a jar full. A small jar of file' goes a long ways, because not much is used in a bowl of gumbo. How to use file' as a table condiment on gumbo. File' is sprinkled on the surface of your gumbo at the table. File' makes the gumbo thick if you let it set for awhile. Don't add file' to the gumbo during cooking or else it will make the gumbo thick and stringy.
Heart failure means that your heart muscle doesn't pump as much blood as your body needs. Because your heart cannot pump well, your heart and your body try to make up for it. This is called compensation. Your body has a remarkable ability to compensate for heart failure. The body may do such a good job that many people don't feel symptoms in the earlier stages of heart failure.
Renin-Angiotensin-Aldosterone System. 1  Specialized cells in the distal tubule called the macula densa sense the concentration of sodium and chloride. 2  If blood pressure falls there is a reduction in concentration of sodium and chloride in the distal tubule which is sensed by the macula densa. The macula densa releases prostaglandins which act on the juxtaglomerular apparatus which releases renin into the bloodstream. The drop in blood pressure is also detected by baroreceptors in the aortic arch, carotid sinus and the afferent renal arteriole which stimulates renin release by the juxtaglomerular apparatus. Renin cleaves angiotensinogen into angiotensin 1 which in turn is cleaved by Angiotensin Converting Enzyme into angiotensin 2.