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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
GLP-1 is an intestinal hormone that is secreted from L-cells in the intestinal mucosa after meals resulting in Stimulation of insulin secretion Suppression of glucagon secretion Delays gastric emptying Enhances satiety Enhances beta cell replication Rapidly degraded by protease dipeptidyl peptidase IV (DPP-IV).