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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
1 There is no known way to prevent myelofibrosis, except in cases caused by exposure to radiation or industrial chemicals. 2  Patient history and physical examination are necessary. 3  Blood tests show abnormal numbers and appearance of blood cells.  A bone marrow biopsy is necessary for a definite diagnosis.