As folate is vital in the first trimester of pregnancy for healthy fetal development, the use of antifolates is strongly contraindicated in pregnancy and carries significant teratogenic risk. Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency.
Cause of Adult Mumps. Adult mumps is caused by an infection with the mumps virus, which is found worldwide. The mumps virus is an RNA (ribonucleic acid) virus from the family Paramyxovirus of the genus Rubulavirus. The mumps virus only infects humans.
What Causes Thrush in Adults. There are plenty of factors that can disturb the natural ecosystem of microorganisms that live in your mouth, unfortunately. Oral thrush is most common in people who: 1  Wear dentures (especially ill-fitting dentures). 2  Have compromised immune systems (from cancer treatment or HIV/AIDS, for example). 3  Have diabetes.