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Freebase(0.00 / 0 votes)Rate this definition: OSIsoft. OSIsoft, LLC is a worldwide manufacturer of Application software for real-time data infrastructure solutions, called the PI System. Founded in 1980, OSIsoft, LLC is privately held and headquartered in San Leandro, CA, with operations worldwide.
OSI Model. 1  The Physical Layer (Layer 1) 2  The Data Link Layer (Layer 2) 3  The Network Layer (Layer 3) 4  The Transport Layer (Layer 4) 5  The Session Layer (Layer 5) 6  The Presentation Layer (Layer 6) 7  The Application Layer (Layer 7)