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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Here is a quick overview of this complex and fascinating network. Ghrelin, the most predominant âhunger hormoneâ identified to date, is a peptide released by endocrine cells mostly within the stomachâs lining. It counteracts leptin to increase metabolic efficiency and stimulate appetite.