Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which abnormal cysts develop and grow in the kidneys. Cystic disorders can express themselves at any point, infancy, childhood, or adulthood.The disease occurs in humans and some other animals.PKD is characterized by the presence of multiple cysts (hence, polycystic) typically in both kidneys; however, 17% of cases initially present with observable disease in one kidney, with most cases progressing to bilateral disease in adulthood.utosomal dominant polycystic kidney disease (ADPKD) is the most common of all the inherited cystic kidney diseases with an incidence of 1:500 live births. Studies show that 10% of end-stage kidney disease (ESKD) patients being treated with dialysis in Europe and the U.S. were initially diagnosed and treated for ADPKD.
The Sacramento River is the largest river and watershed system in California (by discharge, it is the second largest U.S. river draining into the Pacific, after the Columbia River).
San Francisco Bay is a shallow estuary in the U.S. state of California. It is surrounded by a contiguous region known as the San Francisco Bay Area, and is dominated by the large cities of San Francisco, Oakland, and San Jose. San Francisco Bay drains water from approximately 40 percent of California. Water from the Sacramento and San Joaquin rivers, and from the Sierra Nevada mountains, flow into Suisun Bay, which then travels through the Carquinez Strait to meet with the Napa River at the entr