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Antibiotics will stay in your system fro 7 to 10 days.... Antibiotics will stay in your system fro 7 to 10 days. The actual time will depend upon the type of antibiotic taken, the dosage of the antibiotic taken and individual human body as well. Some antibiotics may stay for shorter durations than this also. jack perry.
Bactrim will stay in your system for up to 10 days after you stop  taking it. Bactrim is an antibiotic that is given for a wide  variety of infections. 3 people found this useful.