Secondly, applied research, which is the application of basic research to understanding how behaviour can be changed in everyday setting. When applied research is conducted using samples that are representative of the population to demonstrate effective behaviour change it is particularly relevant to policy makers.
Making the world better, one answer at a time. During skeletal muscle contraction calcium ions expose myosin binding sites on to the actin. When a nerve sends a signal to a muscle to do some action the release of acetylcholine at the neuromuscular junction triggers calcium to be released into the cytoplasm. At rest, the cell has a low concentration of calcium.
Calcium ions are important for cellular signalling, as once they enter the cytosol of the cytoplasm they exert allosteric regulatory effects on many enzymes and proteins. Calcium can act in signal transduction resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors.