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biology of prions Dr. Stanley Prusiner coined the term prion in 1982, which he defined as a small infectious pathogen containing protein but apparently lacking nucleic acid . The prion protein (PrP) is the critical component of these agents and may, in fact, be its exclusive constituent.
Prions and Prion disease. Prion diseases, also known as transmissible spongiform encephalopathies (TSE's) are a group of progressive neurodegenerative conditions. These illnesses exist in both animals and humans.Scrapie, a disease affecting sheep and goats, was the first prion disease to be identified in the 1730s.In more recent years other prion diseases have been seen in animals, the most common of which is bovine spongiform encephalopathy (BSE).ost cases of prion disease are sporadic; that is, they arise spontaneously for no known reason. More rarely prion disease is inherited due to a faulty gene, or acquired by medical procedures, transfusions, or contaminated food. Sporadic and inherited prion disease occurs worldwide in all populations.