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Quadriceps weakness can be caused by various injuries to the knee or hips, acquired myopathies (diseases that affect muscle tissue) such as Lyme disease and poliomyelitis, inherited myopathies such as certain muscular dystrophies and stroke, or neurological diseases such as multiple sclerosis or Bellâs palsy.
An imbalance between weak quadriceps and stronger hamstrings can also cause the injury, a condition that is common among runners. Tight quads can also cause the same problem. When the quadriceps are hit with a direct blow, like when being tackled or blocked in football or checked in hockey, theyâre at risk of injury.