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Wiktionary (0.00 / 0 votes) Rate this definition: disease (Noun). An abnormal condition of the body or mind that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired. The tomato plants had some kind of disease that left their leaves splotchy and fruit withered. disease (Noun). Any abnormal or harmful condition, as of society, people's attitudes, way of living etc. disease (Verb). To cause unease; to annoy, irritate. disease (Verb). To infect with a disease.
B1 [ C or U ] (an) illness of people, animals, plants, etc., caused by infection or a failure of health rather than by an accident: a contagious/infectious disease. a common/rare/incurable/fatal disease. They reported a sudden outbreak of the disease in the south of the country.