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biology of prions Dr. Stanley Prusiner coined the term prion in 1982, which he defined as a small infectious pathogen containing protein but apparently lacking nucleic acid . The prion protein (PrP) is the critical component of these agents and may, in fact, be its exclusive constituent.
In 1982 he and his colleagues isolated a protein that was capable of transmitting infection but, unlike all other known pathogens, contained neither DNA nor RNA. Prusiner's term for this protein, prion, was derived from the phrase proteinaceous infectious particle.priÂ·on/ (priÂ´on) any of several transmissible forms of the core of prion protein that cause a group of neurodegenerative diseases. Prions differ in structure from normal prion protein, lack detectable nucleic acid, and do not elicit an immune response.