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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Amylin is a peptide of 37 amino acids, which is also secreted by the beta cells of the pancreas. Some of its actions: 1  inhibits the secretion of glucagon; 2  slows the emptying of the stomach; 3  sends a satiety signal to the brain.he alpha cells of the islets secrete glucagon, a polypeptide of 29 amino acids. Glucagon acts principally on the liver where it stimulates the conversion of. 1  glycogen into glucose ( glycogenolysis ) and. 2  fat and protein into intermediate metabolites that are ultimately converted into glucose (gluconeogenesis).