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Quadriceps weakness can be caused by various injuries to the knee or hips, acquired myopathies (diseases that affect muscle tissue) such as Lyme disease and poliomyelitis, inherited myopathies such as certain muscular dystrophies and stroke, or neurological diseases such as multiple sclerosis or Bellâs palsy.
In this article. Rheumatic diseases affect your joints and muscles. Some, like osteoarthritis, are the result of wear and tear. Others, such as rheumatoid arthritis, are immune system problems.ymptoms: 1  Pain and swelling in multiple joints (usually the same joints on both sides of your body, like both wrists or both ankles). 2  Problems in other organs such as eyes and lungs. 3  Joint stiffness, especially in the morning. 4  Fatigue.