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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
Myelofibrosis occurs when blood stem cells develop a genetic mutation. Blood stem cells have the ability to replicate and divide into the multiple specialized cells that make up your blood â red blood cells, white blood cells and platelets. It's not clear what causes the genetic mutation in blood stem cells.