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biology of prions Dr. Stanley Prusiner coined the term prion in 1982, which he defined as a small infectious pathogen containing protein but apparently lacking nucleic acid . The prion protein (PrP) is the critical component of these agents and may, in fact, be its exclusive constituent.
Prion diseases are a group of neurodegenerative diseases caused by prions, which are âproteinaceous infectious particles.â For some background, first see this introduction to prions. Prion diseases are caused by misfolded forms of the prion protein, also known as PrP.