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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
DNase is an enzyme (a protein-like substance) that cuts the DNA present in the mucus. At first DNase was made from cows, but many patients had allergic reactions to it. Then a company separated the gene for human deoxyribonuclease, which chops up the protein but does not cause allergic reactions. DNase is delivered to the patient in aerosol form, and it improves lung function by breaking up the thick mucus in the lungs.