What physicians need to know about restrictive covenants. Roy W. BreitenbachThe mention of restrictive covenants provokes an almost visceral reaction among most physicians. But keep in mind these covenants are, for the most part, enforceable.
An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. medicinal enzyme inhibitor is often judged by its specificity (its lack of binding to other proteins) and its potency (its dissociation constant, which indicates the concentration needed to inhibit the enzyme). A high specificity and potency ensure that a drug will have few side effects and thus low toxicity.
Changes in activity of enzymes due to the actual process of insolubilization have not been studied very much. There is usually a decrease in specific activity of an enzyme upon insolubilization, and this can be attributed to denaturation of the enzymic protein caused by the coupling process.ven the linkages between enzyme and support can be non-biodegradable, as with the titanium procedure. As far as the biodegradability of the enzyme, in some cases, when in active use, enzymes will partially protect themselves, notably all those that effect oxidation with production of hydrogen peroxide as a by product.