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It is important to distinguish between a normal decline of testosterone levels and hypogonadism. Signs and symptoms of low testosterone include: 1  Change in sleep patterns: insomnia or sleep disturbances. 2  Physical changes: increased body fat and reduced muscle bulk. 3  Sexual changes: reduced sexual desires, sexual dysfunction, or infertility.
Low Estrogen Explains Some Hypogonadal Symptoms in Men. Testosterone deficiency in men accounts for decreases in lean mass, muscle size, and strength, whereas estrogen deficiency primarily accounts for increases in body fat, according to a new study. Deficiency of both hormones contributes to a decrease in sexual function. âOur findings support changes in the approach to evaluation and management of hypogonadism in men,â investigators concluded in the New England Journal of Medicine (2013;369:1011-1022).