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Preheat the oven to 450 degrees F. Season salmon with salt and pepper. Place salmon, skin side down, on a non-stick baking sheet or in a non-stick pan with an oven-proof handle. Bake until salmon is cooked through, about 12 to 15 minutes.
1 A two-inch thick fillet will bake for 20 minutes. 2  A 1-1/2 filet will take 15 minutes and so on. 3  Check the salmon frequently. 4  Start checking at about 10 minutes, and keep checking until the flesh of the fish is just barely an opaque pink.ere are some general guidelines for baking salmon. 1  A good rule of thumb is that at 350 degrees the salmon will bake about ten minutes per one inch thickness of your fillet. 2  A two-inch thick fillet will bake for 20 minutes.