Medications or substances causing Leg weakness. The following drugs, medications, substances or toxins are some of the possible causes of Leg weakness as a symptom. This list is incomplete and various other drugs or substances may cause your symptoms (see Leg weakness). Always advise your doctor of any medications or treatments you are using, including prescription, over-the-counter, supplements, herbal or alternative treatments. 1  Acrivatine and Pseudoephedrine.
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