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1 Insulin sensitivity is increased, so your cells are better able to use any available insulin to take up glucose during and after activity. 2  When your muscles contract during activity, it stimulates another mechanism that is completely separate of insulin.
The buffering capacity is relatively high in the cytosol and blood but low in the interstitial fluid due to limited buffering factors such as proteins [45, 46]. Therefore, interstitial fluid pH in metabolic tissues easily changes (Figure 1) and may contribute to the onset of insulin resistance.