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In the 1980s, Welker voiced many recurring characters in the original Transformers animated series. He voiced several Decepticons, including the leader Megatron, Soundwave, Skywarp, Mixmaster, Laserbeak, Buzzsaw, Rumble, Frenzy, Ravage and Ratbat, as well as Autobots Mirage, Trailbreaker and Sludge.
In the second Transformers film, Transformers: Revenge of the Fallen (2009), he joined the voice cast and reprised the roles of Soundwave and Ravage, and also provided the voices for Grindor, Devastator and Reedman.