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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Cholecystokinin (CCK)is secreted in response to fats and peptides in the upper small intestines, particularly the duodenum. 1  Actions of CCK include: 2  Secretion of Pancreatic Enzymes. 3  Contraction of Gallbladder. 4  Relaxation of the sphincter of Oddi. 5  increased tension in the pyloric sphincter, inhibiting stomach emptying.