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Quadriceps weakness can be caused by various injuries to the knee or hips, acquired myopathies (diseases that affect muscle tissue) such as Lyme disease and poliomyelitis, inherited myopathies such as certain muscular dystrophies and stroke, or neurological diseases such as multiple sclerosis or Bellâs palsy.
Chronic Lyme disease commonly affects the knees and, less commonly, other large joints. Lupus arthritis may also affect the knees, although the smaller joints of the hands, wrists, ankles and toes are also commonly involved.