Serous Membrane Serous Membrane is composed of a layer simple squamous epithelium resting on a thin layer of areolar connective tissue. The Serous membranes line body cavities that are closed to the exterior. Serous membrane occurs in pairs. The parietal layer lines a specific portion of the wall of the ventral body cavity. It folds in on itself to form the visceral layer, which then converts the outside of the organs in that cavity. These layers are separated by a scanty amount of thin, clear fluid, called serous fluid, which is secreted by both membranes.
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p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). p14ARF is induced in response to elevated mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein).