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Treatment of Depression. The recommended initial dosage of trazodone is 150 mg/day taken in divided doses. The dose may be adjusted every three to four days with increment of 50 mg/day. The maximum daily dose for outpatients is 400 mg/day in divided doses.
In the other case, it was reported that acute dystonia observed 2 weeks after the dose of trazodone had been increased to 50 mg/day (7). There was also no case of tardive dyskinesia reported with trazodone (5). Trazodone has generally antagonistic effect on serotonergic receptors in particular 5-HT1A, 5-HT1C and 5-HT2.