The Structures of Life in PDF Chapter 4: Structure-Based Drug Design: From the Computer to the Clinic In 1981, doctors recognized a strange new disease in the United States. The first handful of patients suffered from unusual cancers and pneumonias.
A recent randomized controlled trial found that vitamin K supplementation in conjunction to vitamin D supplementation reduced the progression of atherosclerosis in patients with chronic kidney disease (CKD) significantly more so than supplementing with vitamin D alone.
Low vitamin D levels were associated with a 5-fold increased risk for progression to tuberculosis. Deficiency of vitamin D (25-hydroxycholecalciferol) has long been implicated in activation of tuberculosis (TB) (1). Serum levels of vitamin D in TB patients are lower than in healthy controls (2, 3). Paradoxically, prolonged treatment of TB also causes a decline in serum vitamin D levels (2).