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Medical Definition of histone. : any of various simple water-soluble proteins that are rich in the basic amino acids lysine and arginine and are complexed with DNA in the nucleosomes of eukaryotic chromatin.
Types of histones. Each octamer has two pairs of different histone proteins: H2A, H2B, H3 and H4. They are arranged as a pair of H2A-H2B dimers, and an (H3)2(H4)2 tetramer. There is an additional type of histone, the linker histone H1, which is present in condensed DNA.istone packaging of DNA is a ubiquitous mechanism throughout species, and the structures of histones are highly conserved. They contain high amounts of two positively charged amino acids: lysine and arginine. Of course, there are some differences between the types of histone proteins: 1  H2A and H2B contain more lysine;