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Treatment of Depression. The recommended initial dosage of trazodone is 150 mg/day taken in divided doses. The dose may be adjusted every three to four days with increment of 50 mg/day. The maximum daily dose for outpatients is 400 mg/day in divided doses.
-For patients receiving a total daily baseline ORAL morphine equivalent dose less than 100 mg: estimate the daily oral methadone requirement at 20% to 30%. -For patients receiving a total daily baseline ORAL morphine equivalent dose of 100 to 300 mg: estimate the daily oral methadone requirement at 10% to 20%. -For patients receiving a total daily baseline ORAL morphine equivalent dose of 300 to 600 mg: estimate the daily oral methadone requirement at 8% to 12%.