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Medical Definition of Sharpey's fiber. : any of the thready processes of the periosteum that penetrate the tissue of the superficial lamellae of bones.
Nerve Fiber: Nerve fiber is a thread like extension of a neuron, which is formed by the axon and its covering. Thus each nerve fiber is an axon with its coverings. Larger axons are covered by a myelin sheath and are termed myelinated or medullated fibers.