In addition to the sciatic nerve, many other nerve roots in the lumbar (lower) spine serve the legs, so a bulging disc at any point between the five vertebrae of the lumbar spine (L1 to L5) â or between the bottom of the lumbar spine and sacrum (L5 to S1) could result in leg pain.
A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.Fibroblasts are the most common cells of connective tissue in animals.ibroblasts and fibrocytes are two states of the same cells, the former being the activated state, the latter the less active state, concerned with maintenance and tissue metabolism.
Cardiac fibrosis occurs when abnormal amounts of fibrous scar tissue are formed within the heart muscle. The overgrowth of the scar tissue may happen after a heart attack or occur as heart disease progresses, and the heart muscle becomes stiff and unable to pump blood efficiently.keletal muscle fibrosis may be a symptom of a muscle disorder. Some people with Duchenne or Becker muscular dystrophy develop large amounts of fibrous tissue as the healthy muscle tissue degrades.