The Structures of Life in PDF Chapter 4: Structure-Based Drug Design: From the Computer to the Clinic In 1981, doctors recognized a strange new disease in the United States. The first handful of patients suffered from unusual cancers and pneumonias.
A recent randomized controlled trial found that vitamin K supplementation in conjunction to vitamin D supplementation reduced the progression of atherosclerosis in patients with chronic kidney disease (CKD) significantly more so than supplementing with vitamin D alone.
Impaired renal function (usually, estimated GFR from stable serum creatinine level <20 mL/min) can cause hyperkalemia. In the setting of preserved renal function (GFR >20 mL/min), serum aldosterone, renin, and cortisol levels can distinguish other causes .