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Step 3. Talk to your doctor about possible medical causes for the puffiness. Certain medications can cause you to retain water, and allergies, conjunctivitis and allergies --such as hay fever--can cause your face to look puffy. If thereâs a medical cause behind the problem, your health care provider will recommend a change in medication or other adjustments to fix the problem.
Finally, some drugs can cause face swelling, including commonly used medications like aspirin, penicillin, prednisone, and the substance inside asthma inhalers. Some diseases can result in swelling in the face, even when it does not seem like the face should be affected by the medical condition at all. For example, kidney disease may cause this issue, as a malfunctioning kidney can fill the body with fluids, though this is usually also accompanied by swollen hands and feet.