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Japanese encephalitis (JE) is the leading cause of viral encephalitis in Asia, with up to 70,000 cases reported annually. Case-fatality rates range from 0.3% to 60% and depend on the population and age. Rare outbreaks in U.S. territories in the Western Pacific have also occurred.
Tick-borne encephalitis (TBE) is an acute viral illness caused by two closely related viruses of the family Flaviviridae: the central European encephalitis (CEE) virus, found in many European countries, and the Russian spring-summer encephalitis (RSSE) virus, found predominantly in the Asian parts of the former Soviet Union.