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Japanese encephalitis (JE) is the leading cause of viral encephalitis in Asia, with up to 70,000 cases reported annually. Case-fatality rates range from 0.3% to 60% and depend on the population and age. Rare outbreaks in U.S. territories in the Western Pacific have also occurred.
Bacterial infections and noninfectious inflammatory conditions also may cause encephalitis. An infection may result in one of two conditions affecting the brain: 1  Primary encephalitis occurs when a virus or other infectious agent directly infects the brain. 2  The infection may be concentrated in one area or widespread. Herpes simplex virus. 2  There are two types of herpes simplex virus (HSV). 3  Either type can cause encephalitis. 4  HSV type 1 (HSV-1) is usually responsible for cold sores or fever blisters around your mouth, and HSV type 2 (HSV-2) commonly causes genital herpes.