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Penicillin Mode of Action - Enzyme Inhibition: All penicillin derivatives produce their bacteriocidal effects by inhibition of bacterial cell wall synthesis. Specifically, the cross linking of peptides on the mucosaccharide chains is prevented.
Penicillins What are Penicillins. Penicillins are a type of antibiotic derived from Penicillium fungi. Alexander Fleming discovered the first penicillin in 1928 (benzylpenicillin also called penicillin G). Since then, several other penicillins have been derived, and the original structure has been modified to create new penicillins with enhanced effectiveness against a broader range of bacteria.