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Other medications that can cause flushing are corticotropin- releasing hormone, doxorubicin, and niacin (Box 1). Flushing is a side effect of sildenafil citrate in 12% of patients. Systemic administration of morphine can cause flushing of the face, neck, and upper shoulders, which is believed to be histamine-mediated.
A hot flush is a vasomotor or blood vessel symptom that can vary in intensity and duration. A typically hot flush will last for between 30 seconds and 10 minutes. We may experience an unannounced brief feeling of intense heat that makes our face and neck feel red and hot and possibly look blotchy. Some women report what feels like a sudden rush of blood from their toes to the top of their head.