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Medical Definition of histone. : any of various simple water-soluble proteins that are rich in the basic amino acids lysine and arginine and are complexed with DNA in the nucleosomes of eukaryotic chromatin.
Chromatin is made of DNA and proteins (Histones). Chromatin is used to give structure to a chromosome. Nucleosome consists of the acidic chromatin and the basic histone proteins. Histone chaperones Histone chaperone guided folding pathways, assists in the folding and unfolding of the DNA around the histone.