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Bake in a 350 F oven for 45 minutes to an hour or until the center registers 160 F on an instant-read thermometer. 1  Resist the urge to cook any form of ground beef to anything less than well-done as E coli is a real risk for undercooked ground beef.eal the foil packets tightly and bake in a 350-degree Fahrenheit oven for 45 minutes or until the beef registers 160 degrees on an instant-read thermometer when inserted horizontally into the patty.
Place the ground beef in the slow cooker. If the meat is very lean, add about 1/2 cup of water. Cook on high for 2 hours, then break ground beef into smaller chunks. Cook on low setting for 4 more hours, until the ground beef is browned.