Collagenase is potentially irreversibly inactivated at pH <5 and reversibly inactivated at pH â¥8.5; activity can be restored by return of pH to 7.4.a. Collagenase can be destroyed by other proteolytic enzymes or by exposure to temperatures >56Â°C.a.
Splenectomy is a surgical procedure to remove your spleen. The spleen is an organ that sits under your rib cage on the upper left side of your abdomen. It helps fight infection and filters unneeded material, such as old or damaged blood cells. The most common reason for splenectomy is to treat a ruptured spleen, often caused by an abdominal injury.
Treatments for leukemia include chemotherapy (major treatment modality for leukemia), radiation therapy, biological therapy, targeted therapy, and stem cell transplant. Combinations of these treatments may be used. Surgical removal of the spleen can be a part of treatment if the spleen is enlarged. Acute leukemia needs to be treated when it is diagnosed, with the goal of inducing a remission (absence of leukemia cells in the body). After remission is achieved, therapy may be given to prevent a relapse of the leukemia.