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Hyperuricemia is an excess of uric acid in the blood. Uric acid passes through the liver, and enters your bloodstream. Most of it is excreted (removed from your body) in your urine, or passes through your intestines to regulate normal levels.auses of high uric acid levels include 1  : Primary hyperuricemia. 2  Increased production of uric acid from purine. 3  Your kidneys cannot get rid of the uric acid in your blood, resulting in high levels. 4  Secondary hyperuricemia. 5  Certain cancers, or chemotherapy agents may cause an increased turnover rate of cell death.
Underexcretion of uric acid by the kidney is the primary cause of hyperuricemia in about 90% of cases, while overproduction is the cause in less than 10%. About 10% of people with hyperuricemia develop gout at some point in their lifetimes.