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Japanese encephalitis (JE) is the leading cause of viral encephalitis in Asia, with up to 70,000 cases reported annually. Case-fatality rates range from 0.3% to 60% and depend on the population and age. Rare outbreaks in U.S. territories in the Western Pacific have also occurred.
The condition is rare, affecting around 4,000 people in the UK each year. In its early stages, encephalitis has flu-like symptoms, including fever, headache and joint pain. Over some days or hours, other more serious symptoms develop. These include seizures, personality changes, confusion, drowsiness or disorientation.