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Causes of Restlessness: The following medical conditions are some of the possible causes of Restlessness. There are likely to be other possible causes, so ask your doctor about your symptoms. Anxiety - general everyday anxiety may cause restlessness as a symptom. Anxiety disorders - almost all anxiety disorders may cause restlessness symptoms.
1 Not enough sleep or disruptions to the sleep-wake cycle (such as those that may occur with shift work or travelling to a different time zone) cause the physiological state known as fatigue.  Staying awake for 24 hours leads to a reduced hand-to-eye coordination that is similar to having a blood alcohol content of 0.1.