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In most cases, doctors do not know the cause of restless legs syndrome; however, they suspect that genes play a role. Nearly half of people with RLS also have a family member with the condition. Other factors associated with the development or worsening of restless legs syndrome include: Chronic diseases.
1 Not enough sleep or disruptions to the sleep-wake cycle (such as those that may occur with shift work or travelling to a different time zone) cause the physiological state known as fatigue.  Staying awake for 24 hours leads to a reduced hand-to-eye coordination that is similar to having a blood alcohol content of 0.1.