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Penicillin Mode of Action - Enzyme Inhibition: All penicillin derivatives produce their bacteriocidal effects by inhibition of bacterial cell wall synthesis. Specifically, the cross linking of peptides on the mucosaccharide chains is prevented.
Classification of Penicillins and Spectrum of Activity. The penicillin compounds can be divided into categories based upon their spectrum of activity (Table 1). Minimum inhibitory concentration (MIC) data for 50% and 90% of specific organisms are located in Tables 2 and 3 (10, 70, 150, 228, 245, 255, 257, 261).