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Japanese encephalitis (JE) is the leading cause of viral encephalitis in Asia, with up to 70,000 cases reported annually. Case-fatality rates range from 0.3% to 60% and depend on the population and age. Rare outbreaks in U.S. territories in the Western Pacific have also occurred.
Encephalitis is most commonly due to viruses, such as herpes simplex, herpes zoster, cytomegalovirus, or West Nile virus. It can occur in the following ways: A virus directly infects the brain. A virus that caused an infection in the past becomes reactivated and directly damages the brain.