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Medical Definition of histone. : any of various simple water-soluble proteins that are rich in the basic amino acids lysine and arginine and are complexed with DNA in the nucleosomes of eukaryotic chromatin.
DNA and histone proteins are packaged into structures called chromosomes. In the nucleus of each cell, the DNA molecule is packaged into thread-like structures called chromosomes. Each chromosome is made up of DNA tightly coiled many times around proteins called histones that support its structure.Chromosomes are not visible in the cellâs nucleusânot even under a microscopeâwhen the cell is not dividing.ach chromosome is made up of DNA tightly coiled many times around proteins called histones that support its structure. Chromosomes are not visible in the cellâs nucleusânot even under a microscopeâwhen the cell is not dividing.