In addition to the sciatic nerve, many other nerve roots in the lumbar (lower) spine serve the legs, so a bulging disc at any point between the five vertebrae of the lumbar spine (L1 to L5) â or between the bottom of the lumbar spine and sacrum (L5 to S1) could result in leg pain.
A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.Fibroblasts are the most common cells of connective tissue in animals.ibroblasts and fibrocytes are two states of the same cells, the former being the activated state, the latter the less active state, concerned with maintenance and tissue metabolism.
Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This can be a reactive, benign, or pathological state.In response to injury, this is called scarring, and if fibrosis arises from a single cell line, this is called a fibroma.Physiologically, fibrosis acts to deposit connective tissue, which can obliterate the architecture and function of the underlying organ or tissue.ibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include: Micrograph showing cirrhosis of the liver. The tissue in this example is stained with a trichrome stain, in which fibrosis is colored blue.