In addition to the sciatic nerve, many other nerve roots in the lumbar (lower) spine serve the legs, so a bulging disc at any point between the five vertebrae of the lumbar spine (L1 to L5) â or between the bottom of the lumbar spine and sacrum (L5 to S1) could result in leg pain.
A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.Fibroblasts are the most common cells of connective tissue in animals.ibroblasts and fibrocytes are two states of the same cells, the former being the activated state, the latter the less active state, concerned with maintenance and tissue metabolism.
1 Outer fibrous layer: It is composed of collagen-producing cells called fibroblasts and contains nerve fibers that cause pain when damaged due to the presence of nociceptive nerve endings. 2  It also has a rich supply of blood vessels and branches, which pierces the bone to supply the osteocytes, or bone cells.t mainly comprises of the following two layers: 1  Outer fibrous layer: It is composed of collagen-producing cells called fibroblasts and contains nerve fibers that cause pain when damaged due to the presence of nociceptive nerve endings.