In addition to the sciatic nerve, many other nerve roots in the lumbar (lower) spine serve the legs, so a bulging disc at any point between the five vertebrae of the lumbar spine (L1 to L5) â or between the bottom of the lumbar spine and sacrum (L5 to S1) could result in leg pain.
A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.Fibroblasts are the most common cells of connective tissue in animals.ibroblasts and fibrocytes are two states of the same cells, the former being the activated state, the latter the less active state, concerned with maintenance and tissue metabolism.
They are appropriately called fibrocytes as against 'fibroblasts' which are active cells. the cells are flattented amongst the collagen bundles, their cytoplasm hardly visible and the nuclei are flat. in regular dense connective tissue (tendons) the collagen bundles are more-or-less parallel and so are the rows of fibrocyte nuclei.