In addition to the sciatic nerve, many other nerve roots in the lumbar (lower) spine serve the legs, so a bulging disc at any point between the five vertebrae of the lumbar spine (L1 to L5) â or between the bottom of the lumbar spine and sacrum (L5 to S1) could result in leg pain.
A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.Fibroblasts are the most common cells of connective tissue in animals.ibroblasts and fibrocytes are two states of the same cells, the former being the activated state, the latter the less active state, concerned with maintenance and tissue metabolism.
As you explore the specific types of connective tissue proper you will see these contain three types of protein fibers and in some cases, a variety of cell types. Type, abundance, and orientation of protein fibers determine the kind of connective tissue proper. The forming and mature cells of connective tissue proper are called fibroblasts or fibrocytes respectively. A clear distinction between these two types is difficult. Try to remember the fibroblast as the more active cell that forms fibers and ground substance. Therefore, in a young forming tissue these cells prevail.