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Other medications that can cause flushing are corticotropin- releasing hormone, doxorubicin, and niacin (Box 1). Flushing is a side effect of sildenafil citrate in 12% of patients. Systemic administration of morphine can cause flushing of the face, neck, and upper shoulders, which is believed to be histamine-mediated.
If you take more than 1000 mg, you are likely to experience warm, red and possibly itchy skin. Nicotinic acid is the only form of niacin associated with health benefits and the only one that will cause significant flushing. Flush-free niacin is IHN and made of six niacin molecules linked together by the chemical inositol.