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Treatment of Depression. The recommended initial dosage of trazodone is 150 mg/day taken in divided doses. The dose may be adjusted every three to four days with increment of 50 mg/day. The maximum daily dose for outpatients is 400 mg/day in divided doses.
Your doctor may lower your dose of trazodone if you are also prescribed one of these: 1  clarithromycin. 2  fluoxetine. 3  indinavir. itraconazole. 4  ketoconazole. ritonavir.  the herbal remedy St John's wort (Hypericum 1  perforatum) telaprevir.