Collagenase is potentially irreversibly inactivated at pH <5 and reversibly inactivated at pH â¥8.5; activity can be restored by return of pH to 7.4.a. Collagenase can be destroyed by other proteolytic enzymes or by exposure to temperatures >56Â°C.a.
Splenectomy is a surgical procedure to remove your spleen. The spleen is an organ that sits under your rib cage on the upper left side of your abdomen. It helps fight infection and filters unneeded material, such as old or damaged blood cells. The most common reason for splenectomy is to treat a ruptured spleen, often caused by an abdominal injury.
As you've seen, your spleen is a very useful organ, but it is not vital. Sometimes, a person's spleen does have to be surgically removed. This may be because the spleen becomes injured, or it may be taken out in the course of transplanting other organs. Other parts of your body, like your lymph nodes and your liver, are able to step in and take over many of your spleen's functions.