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A more severe form is systemic nickel allergy syndrome (SNAS), which is clinically characterized by cutaneous manifestations (such as contact dermatitis, pompholyx, hand dermatitis, dyshydrosis, and urticaria), a long-term course, and systemic symptoms (such as headache, asthenia, itching, and gastrointestinal disorders related to histopathologic alterations of gastrointestinal mucosa, borderline with celiac disease).
The doctor puts tiny amounts of nickel and other allergens on patches, which are applied to your upper back. The patches must stay on for 48 hours. If you are allergic to nickel, your skin will likely show a reaction after 48 hours. In some cases, you'll need more tests.