Collagenase is potentially irreversibly inactivated at pH <5 and reversibly inactivated at pH â¥8.5; activity can be restored by return of pH to 7.4.a. Collagenase can be destroyed by other proteolytic enzymes or by exposure to temperatures >56Â°C.a.
Splenectomy is a surgical procedure to remove your spleen. The spleen is an organ that sits under your rib cage on the upper left side of your abdomen. It helps fight infection and filters unneeded material, such as old or damaged blood cells. The most common reason for splenectomy is to treat a ruptured spleen, often caused by an abdominal injury.
The spleen is a vital organ that filters and eliminates infection causing agents from the blood. It also gets rid of old, abnormal blood cells and maintains a normal supply of healthy cells. In normal conditions, the spleen is roughly the size of our fist. When it gets inflamed and swollen, the size increases considerably; and the condition is called splenomegaly. The chief symptom is pain. At first, pain is felt in the upper abdomen; it gradually extends to the left shoulder.