A hosted Open Web App delivers all its content from a Web server, in the same way as a conventional Web site, along with an app manifest in the app's root directory. The app manifest provides details about the app such as its description, icons used to identify the installed app and so on.
Raw opium contains some 20 alkaloid substances, one of which is morphine, in a typical yield of 10%. Morphine was first isolated in 1805 by Friedrich SertÃ¼rner, an apothecary's assistant in Paderborn, Germany, however its basic structure was not correctly determined until 120 years later.
The primary source of morphine is isolation from poppy straw of the opium poppy. In 2013, an estimated 523,000 kg of morphine were produced. About 45,000 kg were used directly for pain, a four-time increase over the last twenty years. Most use for this purpose was in the developed world. About 70% of morphine is used to make other opioids such as hydromorphone, oxymorphone, and heroin.