Despite many patients experiencing improvement in symptoms with steroid use, corticosteroids are not effective in preventing complications or progression of disease. Other reasons for discouraging long-term steroid use are the side effects and risks, which increase with repeated or long-term use. Budesonide (Entocort): is a modified steroid, absorbed in the small intestine and colon. However, unlike prednisone, budesonide is rapidly metabolized by the liver, clearing 80-90% of the medication and thereby reducing systemic exposure, side effects and risks.
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