Moreover, these data entry errors would be hard to detect: Only 0.06% of the errors were blank or outside of the allowable range for the variables. Thus, researchers cannot rely upon histograms and frequency tables to detect data entry errors.
Answer Wiki. Isotretinoin does not cause infertility; what it does cause is devastating birth defects if a woman becomes pregnant while using it. For a female: you have to use totally reliable birth control-that would be the IUD or the implant-to be certain you do not conceive.
The usual dose is 0.5 to 1.0 mg/kg/day for 20 weeks, or a cumulative dose of 120 mg/kg. As side effects are dose-related, the idea of low-dose isotretinoin therapy for less severe forms of acne is attractive, but little data exist on the safety and efficacy of this strategy.Investigators in Israel conducted a prospective, observational, open-label study of isotretinoin in 638 patients with moderate acne.s side effects are dose-related, the idea of low-dose isotretinoin therapy for less severe forms of acne is attractive, but little data exist on the safety and efficacy of this strategy.