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Medical Definition of histone. : any of various simple water-soluble proteins that are rich in the basic amino acids lysine and arginine and are complexed with DNA in the nucleosomes of eukaryotic chromatin.
ketone. 1  any of a class of organic compounds containing a carbonyl group, CO, attached to two alkyl groups, as CH 3 COCH 3 or CH 3 COC 2 H 5 2  . containing the ketone group.