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Bake in a 350 F oven for 45 minutes to an hour or until the center registers 160 F on an instant-read thermometer. 1  Resist the urge to cook any form of ground beef to anything less than well-done as E coli is a real risk for undercooked ground beef.eal the foil packets tightly and bake in a 350-degree Fahrenheit oven for 45 minutes or until the beef registers 160 degrees on an instant-read thermometer when inserted horizontally into the patty.
Preheat oven to 500ÂºF. Season roast generously with salt and pepper. Create a rack, by placing roast bone-side down in pan. Place beef in oven and roast 15 minutes.Turn heat down to 325ÂºF and continue roasting about 2 hours for medium (when thermometer placed in center of roast registers 140ÂºF before resting) or until desired doneness.Because roast sizes vary, figure 12-15 minutes of roasting time per pound after initial sear.nstructions: 1  Preheat oven to 500ÂºF. Season roast generously with salt and pepper. 2  Place beef in oven and roast 15 minutes. 3  Transfer roast to cutting board; loosely tent with foil and let stand 15 to 20 minutes.