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Japanese encephalitis (JE) is the leading cause of viral encephalitis in Asia, with up to 70,000 cases reported annually. Case-fatality rates range from 0.3% to 60% and depend on the population and age. Rare outbreaks in U.S. territories in the Western Pacific have also occurred.
Herpes viruses are the other major cause of encephalitis in the U.S. This virus family includes herpes simplex, Epstein-Barr, cytomegalovirus, and varicella-zoster. Herpes simplex is the most common type of herpes-associated encephalitis.It can cause severe brain damage, but can be treated with antiviral medication..Less common viral causes of encephalitis include enteroviruses, adenoviruses, and viruses associated with childhood diseases such as measles, mumps, and rubella.erpes viruses are the other major cause of encephalitis in the U.S. This virus family includes herpes simplex, Epstein-Barr, cytomegalovirus, and varicella-zoster. Herpes simplex is the most common type of herpes-associated encephalitis.