In addition to the sciatic nerve, many other nerve roots in the lumbar (lower) spine serve the legs, so a bulging disc at any point between the five vertebrae of the lumbar spine (L1 to L5) â or between the bottom of the lumbar spine and sacrum (L5 to S1) could result in leg pain.
A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.Fibroblasts are the most common cells of connective tissue in animals.ibroblasts and fibrocytes are two states of the same cells, the former being the activated state, the latter the less active state, concerned with maintenance and tissue metabolism.
Collagen and elastin are the structure of the skin that maintains both elasticity and firmness. Fibroblast cells create both collagen and elastin matrix that can be activated by glycolic acid and other peels. The special fibroblast cells are found in the papillary level of the second layer of the skin (dermis). Many creams and lotions are marketed to promote collagen formation by fibroblastic activiation.