slide 2 of 12. Skin The skin is the largest organ in the human body. Its main job is to maintain the body's temperature, which means that sweat is created to cool the body, and goosebumps or raised hair occur to trap heat in the body. Along with sweat glands, the skin contains oil glands.
...However, if I am wrong about that, the answer is that acetaminophen (and its metabolites) are identifiable for up to 48 hours after you took the pill. Less if you took tiny doses, but up to standard clinical doses (<8g), it's 48ish hours.
Tylenol's Makeup and Use. To understand how long Tylenol stays in your system, you must know what the drug is and how it is used and metabolized by your body. Tylenol is the brand name for acetaminophen, an over-the-counter analgesic (or pain reliever) and antipyretic (or fever reducer).