Normal RAS signalling pathways. RAS proteins: diversity and processing. The RAS proteins are members of a large superfamily of low-molecular-weight GTP-binding proteins, which can be divided into several families according to the degree of sequence conservation.
Microsoft originally marketed a spreadsheet program called Multiplan in 1982, which was very popular on CP/M systems, but on MS-DOS systems it lost popularity to Lotus 1-2-3. This promoted development of a new spreadsheet called Excel which started with the intention to 'do everything 1-2-3 does and do it better'. The first version of Excel was released for the Mac in 1985 and the first Windows version was released in November 1987. Lotus was slow to bring 1-2-3 to Windows and by 1988 Excel had started to outsell 1-2-3 and helped Microsoft achieve the position of leading PC software developer.
For Microsoft Windows, the game was released on 4 Feburary 2000 for North America and 31 March 2000 for Europe. For Mac OS, the exact date is not confirmed but it was released in 2000 as well. For Playstation 2, it was released on 12 January 2003 for North America, 31 January 2003 for Europe and 29 May 2003 in Japan. For Xbox, it was released on 24 March 2003 in North America and 4 April 2003 for Europe.