slide 2 of 12. Skin The skin is the largest organ in the human body. Its main job is to maintain the body's temperature, which means that sweat is created to cool the body, and goosebumps or raised hair occur to trap heat in the body. Along with sweat glands, the skin contains oil glands.
...However, if I am wrong about that, the answer is that acetaminophen (and its metabolites) are identifiable for up to 48 hours after you took the pill. Less if you took tiny doses, but up to standard clinical doses (<8g), it's 48ish hours.
An overdose of acetaminophen can cause serious harm. The maximum amount of acetaminophen for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking more acetaminophen could cause damage to your liver. Know the amount of acetaminophen in the specific product you are taking.