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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
Ambien is the brand name for zolpidem, a drug that's used to treat insomnia. Insomnia is a sleep disorder that makes it difficult for you to go to sleep, stay asleep, or both. Ambien is in a class of drugs called sedative-hypnotics. They work by slowing the activity in your brain, which allows for a state of sleep. Sanofi-Aventis makes Ambien, which was approved by the Food and Drug Administration (FDA) in 1992.