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There are many types and causes of mouth sores. Mouth sores may be caused by an infection, a bodywide (systemic) disease, a physical or chemical irritant, or an allergic reaction (see Table: Some Causes of Mouth Sores). Often the cause is unknown.
Several conditions can cause a burning sensation in the mouth. Some nutritional deficiencies â particularly of B vitamins, iron and zinc â can cause it. These problems can be detected by simple blood tests. Medicines that cause the mouth to become dry (due to decreased saliva production) can result in mouth irritation.