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Quick Answer.  Noble gases are unreactive because their outer electron shells are full and therefore in their most stable state. Normally, elements react with one another because they have incomplete electron shells. They lose, gain or share electrons in order to gain a more stable electron configuration.
An inert gas is nonreactive with other elements.... Helium and neon are the only true elemental inert gases, because they do not form any true chemical compounds. It is a gas that does not, under normal circumstances, bond with any other element or molecule--i.e. it produces no chemical reactions, hence inert.