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In 1881, Carl Wernicke first described an illness that consisted of paralysis of eye movements, ataxia, and mental confusion, in 3 patients. The patients, 2 males with alcoholism and a female with persistent vomiting following sulfuric acid ingestion, exhibited these findings, developed coma, and eventually died.
Wernicke's area is classically located in the posterior section of the superior temporal gyrus (STG) in the (most commonly) left cerebral hemisphere. This area encircles the auditory cortex on the lateral sulcus (the part of the brain where the temporal lobe and parietal lobe meet). This area is neuroanatomically described as the posterior part of Brodmann area 22. However, there is an absence of consistent definitions as to the location.