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There are many types and causes of mouth sores. Mouth sores may be caused by an infection, a bodywide (systemic) disease, a physical or chemical irritant, or an allergic reaction (see Table: Some Causes of Mouth Sores). Often the cause is unknown.
No one knows what causes these small, painful blisters inside your mouth. Triggers include hypersensitivity, infection, hormones, stress, and not getting enough of some vitamins. Also called aphthous ulcers, canker sores can show up on the tongue, cheek, even your gums. They usually last a week or two.