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In 1881, Carl Wernicke first described an illness that consisted of paralysis of eye movements, ataxia, and mental confusion, in 3 patients. The patients, 2 males with alcoholism and a female with persistent vomiting following sulfuric acid ingestion, exhibited these findings, developed coma, and eventually died.
Signs and symptoms of Wernicke encephalopathy (WE) stem from alterations of carbohydrate metabolism (inadequate absorption, accelerated metabolism or increased intake) together with the deficiency of thiamine (vitamin B1), as thiamine is a vital coenzyme of the Krebs cycle, the key step in metabolism of carbohydrates and energy production [1] [2] [ ...