Its competitor, Otrexup, costs $500 to $600 a month for a 25 mg dose â more than a vial of methotrexate and far more than pills, which cost $20 to $30 for a dozen 2.5 mg tablets.
The leaders of Britain, France, Italy, and Germany held a conference in Munich, Germany, on September 29-30, 1938, in which they agreed to the German annexation of the Sudetenland in exchange for a pledge of peace from Hitler. Czechoslovakia, which was not a party to the Munich negotiations, agreed under significant pressure from Britain and France. On March 15, 1939, Hitler violated the Munich agreement and moved against the Czechoslovak state. The Czech provinces of Bohemia and Moravia were proclaimed a German protectorate and were occupied by German forces. Slovakia became an independent state, closely allied with Germany.
Although it was not actually signed until 1 am on 30 Sept, the Munich Agreement was dated 29 Sept. It promised that the Czech army would pull back from the German areas of Czechoslovakia by 10 October. On the surface, it was NOT a total climbdown.