Also, they determined that when the spleen reached or extended below the lower third of the left kidney, this was highly specific for splenomegaly despite a low sensitivity (sensitivity 20%, specificity 93%). The study validated the use of a simple splenic length measurement for splenic CT volume. When splenic length exceeds 10 cm, a diagnosis of splenomegaly should be made. This clinically practical, accurate, simple measurement replaces multiple-measurement, time-consuming methods, and allows daily routine follow-up, the authors reported.
1 This volume will in addition discuss RNA viruses and bring a historical perspective of where studies began to a more recent molecular approach and vaccine successes in tumor viruses.  This volume will also cover other known oncogenic viruses associated cancers in other mammals in addition to humans.
Apoptosis-induced proliferation may also be the underlying cause of cell and tissue type-specific differences for tumor development. For example, NF-ÎºB activation was found to be a tumor promoter in many tumors including colitis-associated cancer (CAC) and melanoma in mice (Greten et al. 2004; Yang et al.