In patients with connective tissue diseases, it is common for collagen and elastin to become injured by inflammation. Many connective tissue diseases feature abnormal immune system activity with inflammation in tissues as a result of an immune system that is directed against one's own body tissues (autoimmunity).Diseases in which inflammation or weakness of collagen tends to occur are also referred to as collagen diseases. connective tissue disease is any disease that has the connective tissues of the body as a primary target of pathology. The connective tissues are the structural portions of our body that essentially hold the cells of the body together.
One of the Middle Colonies, New Jersey started out as a Proprietary colony but in 1702 it was granted a Royal charter. New Jersey, in 1787, was the third state to ratify the Constitution. (1624) New York (originally New Amsterdam) [Homepage, Constitution]
Middle Colonies, North America. The middle colonies were the Delaware Colony, the New Jersey Colony, the New York Colony, and the Pennsylvania Colony. Their climate helped them become the 'breadbasket' of British North America. Arable land was plentiful and the soil was fertile. The excellent natural harbors helped the middle colonies become traders among the colonies. Due in part to immigration from foreign (Mainland Europe) countries, the people were ethnically and religiously diverse. Geography. These colonies included New York, Pennsylvania, New Jersey, and Delaware.