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When lactose is present, allolactose binds to the lac repressor, causing an allosteric change in its shape. In its changed state, the lac repressor is unable to bind tightly to its cognate operator. This effect is referred to as induction, because it induces, rather than represses, expression of the metabolic genes.
A Honor Society of Nursing (STTI) answered. Primary lactose intolerance mostly affects your digestive system. It begins in the small intestine, where cells don't produce enough of the enzyme that helps break down lactose, the sugar in dairy products. This means that the body can't absorb that sugar, so it moves on to the large intestine, where it's fermented by bacteria. This fermentation causes symptoms like gas and bloating. It might also lead to abdominal cramps and diarrhea. Most of the time, these symptoms are mild. For some people, diarrhea is severe enough to prevent the intestines from properly absorbing nutrients in food, which can lead to weight loss.