In patients with connective tissue diseases, it is common for collagen and elastin to become injured by inflammation. Many connective tissue diseases feature abnormal immune system activity with inflammation in tissues as a result of an immune system that is directed against one's own body tissues (autoimmunity).Diseases in which inflammation or weakness of collagen tends to occur are also referred to as collagen diseases. connective tissue disease is any disease that has the connective tissues of the body as a primary target of pathology. The connective tissues are the structural portions of our body that essentially hold the cells of the body together.
One of the Middle Colonies, New Jersey started out as a Proprietary colony but in 1702 it was granted a Royal charter. New Jersey, in 1787, was the third state to ratify the Constitution. (1624) New York (originally New Amsterdam) [Homepage, Constitution]
The middle colonies included Pennsylvania, New York, New Jersey, and Delaware. Advantaged by their central location, the middle colonies served as important distribution centers in the English mercantile system. New York and Philadelphia grew at a fantastic rate.he Middle Colonies. William Penn paid 1200 pounds for the land he purchased from the Delaware Indians. Americans have often prided themselves on their rich diversity. Nowhere was that diversity more evident in pre-Revolutionary America than in the middle colonies of Pennsylvania, New York, New Jersey, and Delaware.