As pancreatic cancer progresses and spreads beyond the pancreas, abnormalities that are not specific to pancreatic cancer accumulate. As a result, marker behavior is likely to be significantly different among patients with early-versus late-stage pancreatic cancer (see Fig. 1).he production of tumor markers at different stages in the natural history of pancreatic cancer development. Markers that become readily detectable only in advanced stages of pancreatic ductal adenocarcinoma after the onset of clinical symptoms will not provide opportunities for early detection and cure.
The several advantages to the Engineering Cost Estimating method include: [2] 1  The estimatorâs ability to determine exactly what the estimate includes and whether anything was overlooked, 2  Its unique application to the specific program and manufacturer,  That it gives good insight into major cost contributors, and.
Average costing method in periodic inventory system: When average costing method is used in a periodic inventory system, the cost of goods sold and the cost of ending inventory is computed using weighted average unit cost.Weighted average unit cost is computed using the following formula :verage costing method in perpetual inventory system: When average costing method is used in a perpetual inventory system, an average unit cost figure is computed each time a purchase is made. This average unit cost figure is then used to assign cost to each unit sold until a new purchase is made.