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Serious neuropsychiatric reactions have occurred in patients taking bupropion for smoking cessation [see WARNINGS AND PRECAUTIONS]. The majority of these reactions occurred during bupropion treatment, but some occurred in the context of discontinuing treatment.
For people taking 300 mg daily, the dose should be reduced to 150 mg daily for 2 weeks prior to stopping this medication in the spring. Bupropion extended release tablets should be swallowed whole with fluids. They should not be chewed, crushed, or halved, as this may affect how this medication is absorbed by the body and result in unwanted side effects.