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A female should be retired from breeding at the age of 7 years maximum. A female Yorkie may need to be retired much younger and this will depend on the recommendation of an experienced and trusted veterinarian who makes a determination after evaluating the individual dog's health and history.
A female cat should be allowed to attain her adult size before breeding. If bred early, she will put her energy into feeding the unborn/newborn kittens instead of finishing her growth. She will be 18-24 months old before she is ready for breeding. A male should be 18 months of age prior to being allowed to breed. This allows time to determine if he is healthy and suitable for breeding.