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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
The recommended adult dose of Ambien (zolpidem) is 10 mg as conventional tablets or spray or 12.5 mg as extended-release tablets. Alcohol has an additive effect with Ambien (zolpidem) and the two should not be combined. Ambien (zolpidem) should not be combined with other sedative drugs because of the additive effects. Sporanox (itraconazole) and ketoconazole may increase the blood concentration of Ambien (zolpidem). Rifadin, Rimactane (rifampin) may reduce the concentration of Ambien (zolpidem).