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A female should be retired from breeding at the age of 7 years maximum. A female Yorkie may need to be retired much younger and this will depend on the recommendation of an experienced and trusted veterinarian who makes a determination after evaluating the individual dog's health and history.
Owners who are interested in cat breeding may choose to not neuter their male cats. However, owners who have no interest in breeding their cats should neuter their cats without exception, preferably before the cat reaches the breeding age at six months.