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There are many types and causes of mouth sores. Mouth sores may be caused by an infection, a bodywide (systemic) disease, a physical or chemical irritant, or an allergic reaction (see Table: Some Causes of Mouth Sores). Often the cause is unknown.
Several things can cause mouth ulcers: 1  viral infections like cold sores or hand, foot and mouth disease. 2  oral thrush. 3  injuries like biting, burns or rubbing from braces.  low vitamin 1  levels. diseases like coeliac disease or inflammatory bowel disease.