A collection of particular persons or items, formed into one body; as a corporation aggregate, which is one formed of a number of natural persons; the union of individual charges make an aggregate charge.
Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. The underlying mechanism is that the gene codes for a product that is, for example, used by various cells, or has a signaling function on various targets.A classic example of pleiotropy is the human disease phenylketonuria (PKU).nsourced material may be challenged and removed. (September 2013). Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits, an example being phenylketonuria, which is a human disease that affects multiple systems but is caused by one gene defect.
Atrophy is the general physiological process of reabsorption and breakdown of tissues, involving apoptosis.When it occurs as a result of disease or loss of trophic support due to other disease, it is termed pathological atrophy, although it can be a part of normal body development and homeostasis as well.stronauts in microgravity must exercise regularly to minimize atrophy of their limb muscles. There are many diseases and conditions which cause atrophy of muscle mass. For example diseases such as cancer and AIDS induce a body wasting syndrome called  cachexia , which is notable for the severe muscle atrophy seen.