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Quick Answer.  Noble gases are unreactive because their outer electron shells are full and therefore in their most stable state. Normally, elements react with one another because they have incomplete electron shells. They lose, gain or share electrons in order to gain a more stable electron configuration.
Definition of Noble Gases. The periodic table is divided into 18 vertical columns referred to as groups or families. On the far right side of the periodic table, in group 18 is a unique group of elements known as the noble gases. The noble gases are a group of extremely nonreactive elements that all exist in the gas state. They are often considered to be inert. Inertness refers to an element's tendency to resist change and reactions.