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The narcotic in both medications is the oxycodone, the only difference between the two is the additiâ¦on of Tylenol (aka acetaminophen). The addition of Tylenol does not necessarily make the combo drug more powerful than the straight oxycodone, but is an adjunctive therapy so to speak.
1 What is the difference between regular tylonel and tylonel arthritis? Higher dose: Tylenol arthritis is simply a higher dose (650 mg) of acetaminophen, the active ingredient in tylenol. Regular tylenol typically has 325 mg and the extra strength tylenol has 500 mg. Tylenol (Definition) Tylenol is thename brand for acetomenofin and is used for pain relief and for fever reduction .