Normal RAS signalling pathways. RAS proteins: diversity and processing. The RAS proteins are members of a large superfamily of low-molecular-weight GTP-binding proteins, which can be divided into several families according to the degree of sequence conservation.
Microsoft originally marketed a spreadsheet program called Multiplan in 1982, which was very popular on CP/M systems, but on MS-DOS systems it lost popularity to Lotus 1-2-3. This promoted development of a new spreadsheet called Excel which started with the intention to 'do everything 1-2-3 does and do it better'. The first version of Excel was released for the Mac in 1985 and the first Windows version was released in November 1987. Lotus was slow to bring 1-2-3 to Windows and by 1988 Excel had started to outsell 1-2-3 and helped Microsoft achieve the position of leading PC software developer.
The first generation Audi A4 (known internally as the Typ 8D) debuted in October 1994, with production starting November 1994 and European sales commencing in January 1995 for the 1995 model year.North American sales later began in September 1995 for the 1996 model year.he first generation A4 succeeded the Audi 80. The automaker's internal numbering treats the A4 as a continuation of the Audi 80 lineage, with the initial A4 designated as the B5-series, followed by the B6, B7, B8 and the B9.