As pancreatic cancer progresses and spreads beyond the pancreas, abnormalities that are not specific to pancreatic cancer accumulate. As a result, marker behavior is likely to be significantly different among patients with early-versus late-stage pancreatic cancer (see Fig. 1).he production of tumor markers at different stages in the natural history of pancreatic cancer development. Markers that become readily detectable only in advanced stages of pancreatic ductal adenocarcinoma after the onset of clinical symptoms will not provide opportunities for early detection and cure.
The several advantages to the Engineering Cost Estimating method include: [2] 1  The estimatorâs ability to determine exactly what the estimate includes and whether anything was overlooked, 2  Its unique application to the specific program and manufacturer,  That it gives good insight into major cost contributors, and.
The goal of each cost estimation method is to estimate fixed and variable costs and to describe this estimate in the form of Y = f + v X. That is, Total mixed cost = Total fixed cost + (Unit variable cost Ã Number of units).uestion: The account analysisA method of cost analysis that requires a review of accounts by an experienced employee or group of employees to determine whether the costs in each account are fixed or variable. approach is perhaps the most common starting point for estimating fixed and variable costs.