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Brinzolamide is a carbonic anhydrase inhibitor which has been found to be effective in lowering the elevated intraocular pressure associated with ocular hypertension and glaucoma. The distribution coefficient, IC50 and Ki values for brinzolamide are 6.56, 3.19 nM and 0.13 nM respectively.
However, high doses of penicillin G must be used for the treatment of Group B streptococcal disease for two reasons. First, the MIC of penicillin G for Group B Streptococcus is relatively high, 4-10 fold greater (range 0.01-0.4 Âµg/ml) than that for group A streptococcal strains.