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lipoprotein lipase (LPL), an enzyme that plays a key role in breaking down triglycerides present in chylomicrons and very low-density lipoprotein particles, releasing their fatty acids for entry into tissue cells.
Normal Function. The LDLR gene provides instructions for making a protein called a low-density lipoprotein receptor. This receptor binds to particles called low-density lipoproteins (LDLs), which are the primary carriers of cholesterol in the blood. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals.