The model developed in this paper differs from models using the lead-time crashing approach by explicitly specifying the source of the lead-time reduction cost (i.e., increasing procurement cost), which allows for analyzing the impact between lead-time reduction and buyerâsupplier interactions.
Skin color - patchy. Patchy skin color is areas where the skin color is irregular. Mottling or mottled skin refers to blood vessel changes in the skin that cause a patchy appearance. Considerations. Irregular or patchy discoloration of the skin can be caused by: Changes in melanin, a substance produced in the skin cells that gives skin its color.
Skittling or pharming is a party game in which teenagers indiscriminately mix drugs together, putting themselves at risk for stroke, heart attack, or irreversible brain damage. 9 Children have easy access to medications from medicine cabinets in their own homes and homes of their families and friends (Figure 6).nauthorized use of pharmaceutical and over-the-counter (OTC) drugs by teenagers is a growing national problem. 2 This latest trend in drug abuse by adolescents is called pharming, or the nonmedical use of prescription and OTC cough and cold medications.