Normal RAS signalling pathways. RAS proteins: diversity and processing. The RAS proteins are members of a large superfamily of low-molecular-weight GTP-binding proteins, which can be divided into several families according to the degree of sequence conservation.
Microsoft originally marketed a spreadsheet program called Multiplan in 1982, which was very popular on CP/M systems, but on MS-DOS systems it lost popularity to Lotus 1-2-3. This promoted development of a new spreadsheet called Excel which started with the intention to 'do everything 1-2-3 does and do it better'. The first version of Excel was released for the Mac in 1985 and the first Windows version was released in November 1987. Lotus was slow to bring 1-2-3 to Windows and by 1988 Excel had started to outsell 1-2-3 and helped Microsoft achieve the position of leading PC software developer.
Five years later in 1977, the company once again changed the face of entertainment when it introduced its first home video game console or VCS (video computer system). While Atariâs cartridge-based game console took off with phenomenal success, it wasnât actually the first to market. That award goes to Magnavox for their Odyssey console, which was released in August of 1972. The designer, Ralph Baer, began work on its prototype as early as 1968!