Normal RAS signalling pathways. RAS proteins: diversity and processing. The RAS proteins are members of a large superfamily of low-molecular-weight GTP-binding proteins, which can be divided into several families according to the degree of sequence conservation.
Microsoft originally marketed a spreadsheet program called Multiplan in 1982, which was very popular on CP/M systems, but on MS-DOS systems it lost popularity to Lotus 1-2-3. This promoted development of a new spreadsheet called Excel which started with the intention to 'do everything 1-2-3 does and do it better'. The first version of Excel was released for the Mac in 1985 and the first Windows version was released in November 1987. Lotus was slow to bring 1-2-3 to Windows and by 1988 Excel had started to outsell 1-2-3 and helped Microsoft achieve the position of leading PC software developer.
They released their eponymous debut album, Cage the Elephant, on June 23, 2008 in the United Kingdom and April 21, 2009 in the United States, Japan, Australia, and Canada, to mostly favorable reviews.