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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
SUMMARY: 1.Both Ambien and Ambien CR are types of Zolpidem. 2.Ambien has a lasting effect of 2-3 hours, and the patient can feel the immediate effect kicking in within 30 minutes. 3.Ambien CR, on the other hand, was specially formulated to have longer-lasting effects for as long as seven hours.mbien vs Ambien CR. Insomnia is a difficulty in sleeping or lack of sleep. The rate of those who have insomnia has gone to 15% of the entire American population. But the problem commonly occurs in women who are more exposed to alcoholic substances, cigarette smoking, use of narcotics, and depressing activities.