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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
Ambien can cause sleepwalking and the type of mania and hypomania that are associated with bipolar, or manic-depressive, disorder. Neither of these drugs is intended for long-term use on a daily basis. Xanax shouldn't be used for more than 30 days at a time, and Ambien shouldn't be used for more than 10 days at a time.These drugs are especially dangerous when taken at the same time.Both Xanax and Ambien slow down the central nervous system.anax shouldn't be used for more than 30 days at a time, and Ambien shouldn't be used for more than 10 days at a time. These drugs are especially dangerous when taken at the same time. Both Xanax and Ambien slow down the central nervous system.