[0020]. Any residual functional cell culture DNA is degraded by treatment with less than 1 % BPL (e.g. less than 1 %, 0.75%, 0.5%, 0.25%, 0.2%, 0.1 %, 0.075%, 0.05%, 0.025%, 0.01%, or 0.005%). Preferably, residual functional cell culture DNA is degraded by treatment with between 0.1% and 0.01% BPL.
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