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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
Mixing zolpidem with other substances that suppress the activity of the brain and nerves can slow down your vital functions to a dangerous rate. Zolpidem tartrate, or Ambien, is a hypnotic drug prescribed on a short-term basis to help people fall asleep.aking Zolpidem with Alcohol. In a safety advisory about Ambien CR, the extended-release form of Ambien, the U.S. Food and Drug Administration cautions that mixing alcohol with Ambien increases the drugâs sedative effects on the central nervous system.