Normal RAS signalling pathways. RAS proteins: diversity and processing. The RAS proteins are members of a large superfamily of low-molecular-weight GTP-binding proteins, which can be divided into several families according to the degree of sequence conservation.
Microsoft originally marketed a spreadsheet program called Multiplan in 1982, which was very popular on CP/M systems, but on MS-DOS systems it lost popularity to Lotus 1-2-3. This promoted development of a new spreadsheet called Excel which started with the intention to 'do everything 1-2-3 does and do it better'. The first version of Excel was released for the Mac in 1985 and the first Windows version was released in November 1987. Lotus was slow to bring 1-2-3 to Windows and by 1988 Excel had started to outsell 1-2-3 and helped Microsoft achieve the position of leading PC software developer.
What year did the Xbox 360 Halo 3 edition come out? What year did the piano first come out? The piano was invented about 1700, and remain pretty much of a curiosity until an article written in 1711 by an Italian, Scipione Maffei, which spoke in glowing terms about thâ¦e instrument generated more interest in it. By the 1730's, several manufacturers were in business to build pianos.