Aerodynamics first: The altitude factor of $c_l \cdot Ma^2$ tells you how much lift can be produced at a given flight Mach number, and the wing loading then gives you the minimum density for sustained flight. 0.4 is a good value for $c_l \cdot Ma^2$, and 30 kg/m$^2$ is a feasible wing loading for flight at 30 km.
Get worse with activity and improve with rest. Myasthenia gravis (MG) can affect any of the muscles that you control voluntarily. It can affect muscles of the face, hands, eyes, arms and legs and those muscles involved in chewing, swallowing and talking. Muscles that control breathing and neck movement also can be affected.
Repeated and increasingly prolonged depletion of blood flow to the fingers can cause ulcers in the skin and tissue death (also called necrosis, see Figure 3). The other cause of cold hand or fingers is vaso-occlusion, which happens when one or more of the blood vessels in the hand or wrist become blocked. Raynaudâs Disease and Raynaudâs Phenomenon. There are many specific diseases of blood vessels that can cause vasoconstriction and vaso-occlusion.