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Quick Answer.  Noble gases are unreactive because their outer electron shells are full and therefore in their most stable state. Normally, elements react with one another because they have incomplete electron shells. They lose, gain or share electrons in order to gain a more stable electron configuration.
Neon because it's a noble gas. Noble gases have 8 valence electron which means they have the exact amount of valance electrons to be perfectly stable. Neon. Its in the 8th group and has a full valence shell. All elements in the Noble gases are highly unreactive because they already have a full shell.