Aerodynamics first: The altitude factor of $c_l \cdot Ma^2$ tells you how much lift can be produced at a given flight Mach number, and the wing loading then gives you the minimum density for sustained flight. 0.4 is a good value for $c_l \cdot Ma^2$, and 30 kg/m$^2$ is a feasible wing loading for flight at 30 km.
Get worse with activity and improve with rest. Myasthenia gravis (MG) can affect any of the muscles that you control voluntarily. It can affect muscles of the face, hands, eyes, arms and legs and those muscles involved in chewing, swallowing and talking. Muscles that control breathing and neck movement also can be affected.
The median nerve, which runs through the arm and hand, can cause swelling pain and numbness if injured. Damage to the ulnar nerve causes swelling, pain and numbness in the forearm, hand, and ring and little fingers. Hypoparathyroidism is a rare condition that can cause muscle twitches, seizures, cramps, tingling, and more. Dupuytren's contracture is a condition of the hand tissue that causes the fingers to curl. Diabetic neuropathy is a nerve condition of the extremities causing numbness, tingling, and pain. Scleroderma is an uncommon immune disorder that causes collagen to build up in the tissue, making it harden. Tetany is a mineral imbalance causing painful muscle cramps and twitches in the hands, feet, face, and larynx.