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The average estrus cycle in a dog is approximately twenty-one days and this cycle usually occurs every six to seven months. The first cycle will often depend on the size of the dog. Small breeds such, as Chihuahuas or Toy Poodles will come into heat between five and seven months.
The best age to neuter a Chihuahua is between the age of 8 weeks and 6 months. There are reasons for this. Limited studies have shown that neutering a male at a very young age (6 weeks old or earlier) has shown to cause the legs to develop slightly longer than normal and cause slightly less muscular development.