Patients were stratified according to tumor PD-L1 status assessed in a central laboratory by immunohistochemical testing (positive vs. negative or indeterminate), BRAF mutation status (V600 mutation-positive vs. wild-type) and American Joint Committee on Cancer stage.[Level of evidence: 1iiA]
Swallowing air excessively; Gastroesophageal reflux; Hiatus hernia; Rapid eating; Intense emotions such as fear, anxiety, excitement, joy, or euphoria [citation needed] Carbonated beverages, alcohol, dry breads, and some spicy foods; Opiate drug use; Laughing; Hiccups may be triggered by a number of common human conditions.
1 Hiccups are the result of an involuntary spasm of your diaphragm, which causes the space between your vocal cords to close, leading to the characteristic âhicâ sound.  Overeating, acid reflux, drinking alcohol or carbonated beverages, or emotional stress can trigger hiccups.