Patients were stratified according to tumor PD-L1 status assessed in a central laboratory by immunohistochemical testing (positive vs. negative or indeterminate), BRAF mutation status (V600 mutation-positive vs. wild-type) and American Joint Committee on Cancer stage.[Level of evidence: 1iiA]
Swallowing air excessively; Gastroesophageal reflux; Hiatus hernia; Rapid eating; Intense emotions such as fear, anxiety, excitement, joy, or euphoria [citation needed] Carbonated beverages, alcohol, dry breads, and some spicy foods; Opiate drug use; Laughing; Hiccups may be triggered by a number of common human conditions.
Patient Comments Read 18 Comments Share Your Story. Hiccups are sudden, involuntary contractions of the diaphragm muscle. As the muscle contracts repeatedly, the opening between the vocal cords snaps shut to check the inflow of air and makes the hiccup sound. Irritation of the nerves that extend from the neck to the chest can cause hiccups. Although associated with a variety of ailments (some can be serious such as pneumonia or when harmful substances build up in the blood for example from kidney failure), hiccups are not serious and have no clear reason for occurring.