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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
Greenville County is a county located in the state of South Carolina, in the United States. As of the 2010 census, the population was 451,225, making it the most populous county in the state. In 2016, the estimated population of the county was 498,776. Its county seat is Greenville. The county is also home to the Greenville County School District, the largest school system in South Carolina. County government is headquartered at Greenville County Square. Greenville County is included in the Gree