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These terms cannot be interchanged and have a specific meaning. Efficiency is the ability of an intervention to have effects on a specific marker in relation to a condition without it necessarily been relevant to patients. The study is done under highly controlled conditions with highly compliant participants.
Efficacy is an inherent property of an agonist that determines its ability to produce its biological effect. By definition, it is a property of the drug, not the receptor or tissue. Affinity gets the drug bound to the receptor, and efficacy determines what happens once the drug is bound.wo fundamental properties of agonists are affinity and efficacy. Affinity can be defined as the tenacity with which a drug binds to its receptor. In statistical terms, it can be defined as the probability that a drug molecule will bind to an available receptor at any given instant in time.