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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
Travel thoughts for your from Greenville to Atlanta. Driving By Car: If you were in a car and maintained an average speed of 60mph (96 kmh) over the course of your it would take you around 2.83 hours to get from Greenville to Atlanta.