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Not to be confused with Sodium bicarbonate. Potassium bicarbonate (also known as potassium hydrogen carbonate or potassium acid carbonate) is a colorless, odorless, slightly basic, salty substance.According to the U.S. Food and Drug Administration (FDA), potassium bicarbonate is  generally recognized as safe .There is no evidence of human carcinogenicity, no adverse effects of overexposure, and an undetermined LD50. It is among the food additives encoded by European Union, identified by the initials E 501.ccording to the U.S. Food and Drug Administration (FDA), potassium bicarbonate is  generally recognized as safe . There is no evidence of human carcinogenicity, no adverse effects of overexposure, and an undetermined LD50. It is among the food additives encoded by European Union, identified by the initials E 501.
How to use potassium bicarbonate. Take this medication by mouth as directed by your doctor, usually 1 to 4 times daily. To prevent stomach upset, take each dose with a meal. Dissolve the prescribed number of tablets in at least 4 ounces (120 milliliters) of cold water or juice per tablet.his medication is a mineral supplement used to treat or prevent low amounts of potassium in the blood. A normal level of potassium in the blood is important.