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Pagetâs disease causes bones to grow too large and weak. You can have Pagetâs disease in any bones in your body, but most people have it in their spine, pelvis, skull, or leg bones. The disease may affect only one bone or several bones, but it does not affect the entire skeleton.f you have Pagetâs disease in your leg bones, you may also have bowed legs. Your spine might curve if the disease is in the bones of the spine. People with Pagetâs disease in the bones of the skull sometimes have: 1  Headaches. 2  Hearing loss. 3  Large head size.
The amount of bone tissue in the skeleton, known as bone mass, can keep growing until around age 30. At that point, bones have reached their maximum strength and density, known as peak bone mass. Women tend to experience minimal change in total bone mass between age 30 and menopause.