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Oxidation is defined as the interaction between oxygen molecules and all the different substances they may contact, from metal to living tissue. Technically, however, with the discovery of electrons, oxidation came to be more precisely defined as the loss of at least one electron when two or more substances interact.
Oxidation is the loss of electrons and corresponds to an increase in oxidation state. Reduction is the gain of electrons and corresponds to a decrease in oxidation state. Balancing redox reactions can be more complicated than balancing other types of reactions because both the mass and charge must be balanced.