When we list the infections brought to the New World from the Old, however, we find most of humanity's worst afflictions, among them smallpox, malaria, yellow fever, measles, cholera, typhoid, and bubonic plague. continued.
The present study was carried out to detect the prevalence of EGFR mutations and EML4-ALK fusions in EGFR mutation-negative cases of NSCLC (adenocarcinoma) as well as to evaluate the clinical characteristics of EGFR mutations and EML4-ALK fusions in EGFR mutation-negative cases of NSCLC.
Pilot gene expression profiling studies in patients with CLL identified genes that were differentially expressed between the Ig-unmutated and Ig-mutated CLL subtypes. Here, we have profiled an expanded cohort of 107 patients and show that ZAP-70 is the gene that best distinguishes the CLL subtypes.Ig-unmutated CLL expressed ZAP-70 5.54-fold more highly than Ig-mutated CLL (P -21). ZAP-70 expression correctly predicted IgVH mutation status in 93% of patients.ere, we have profiled an expanded cohort of 107 patients and show that ZAP-70 is the gene that best distinguishes the CLL subtypes. Ig-unmutated CLL expressed ZAP-70 5.54-fold more highly than Ig-mutated CLL (P -21). ZAP-70 expression correctly predicted IgVH mutation status in 93% of patients.