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The major glands of the endocrine system are the pineal gland, pituitary gland, thyroid and parathyroid glands, adrenal glands, pancreas, thymus, ovaries, and testes. There are also other organs in the body that have secondary endocrine functions.These organs include the heart, liver, and kidneys. Hormones can be regulated by other hormones, by glands and organs, and by a negative feedback mechanism. In negative feedback, the initial stimulus is reduced by the response it provokes.he major glands of the endocrine system are the pineal gland, pituitary gland, thyroid and parathyroid glands, adrenal glands, pancreas, thymus, ovaries, and testes. There are also other organs in the body that have secondary endocrine functions.
The endocrine system is made up of glands that produce and secrete hormones, chemical substances produced in the body that regulate the activity of cells or organs. These hormones regulate the body's growth, metabolism (the physical and chemical processes of the body), and sexual development and function. The hormones are released into the bloodstream and may affect one or several organs throughout the body. Hormones are chemical messengers created by the body.