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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
How many miles is it from Columbia SC to Winston Salem NC? 170 miles taking this route: Take I-77 NORTH (towards CHARLOTTE), from Columbia, to I-85 NORTH to GREENSBORO at EXIT 13A in Charlotte, NORTH CAROLINA.Take I-85 NORTH to U.S. â¦52 to WINSTON-SALEM at EXIT 87, near Lexington.