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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
South Carolina SC Maps SC County Maps Greenville County Map. Our map of Greenville County documents the roads, highways, towns, and boundaries in and near Greenville. A great overview map for the Greenville area, including local landmarks like Fountain Inn, Greer, Mauldin, Simpsonville, Travelers Rest, etc.