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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
The total driving time is 2 hours, 13 minutes. Your trip begins in Greenville, South Carolina. It ends in Atlanta, Georgia. If you're planning a road trip, you might be interested in seeing the total driving distance from Greenville, SC to Atlanta, GA. You can also calculate the cost to drive from Greenville, SC to Atlanta, GA based on current local gas prices and an estimate of your car's best gas mileage. If you're meeting a friend, you might be interested in finding the city that is halfway between Greenville, SC and Atlanta, GA.