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Diabetes and high blood pressure are the most common causes of chronic kidney disease that leads to kidney failure. Diabetes or high blood pressure may also speed up the progression of chronic kidney disease in someone who already has the disease.he cause of chronic kidney disease isn't always known. But any condition or disease that damages blood vessels or other structures in the kidneys can lead to kidney disease. The most common causes of chronic kidney disease are:
Causes of Kidney Disease. Most kidney diseases attack the nephrons, causing them to lose their filtering capacity. Damage to the nephrons may happen quickly, often as the result of injury or poisoning. But most kidney diseases destroy the nephrons slowly and silently. Only after years or even decades will the damage become apparent. Most kidney diseases attack both kidneys simultaneously. The two most common causes of kidney disease are diabetes and high blood pressure.