When we list the infections brought to the New World from the Old, however, we find most of humanity's worst afflictions, among them smallpox, malaria, yellow fever, measles, cholera, typhoid, and bubonic plague. continued.
The present study was carried out to detect the prevalence of EGFR mutations and EML4-ALK fusions in EGFR mutation-negative cases of NSCLC (adenocarcinoma) as well as to evaluate the clinical characteristics of EGFR mutations and EML4-ALK fusions in EGFR mutation-negative cases of NSCLC.
In nonâsmall-cell lung cancer (NSCLC), ALK rearrangement occurs in approximately 5% of cases. 2-8 ALK-rearranged tumors depend on ALK for growth and survival and show marked sensitivity to ALK inhibitors such as crizotinib.6-28 In contrast, ceritinib was active in the majority of patients with ALK-rearranged NSCLC who received crizotinib previously. Among these patients, the overall response rate and median progression-free survival observed with ceritinib were similar to those seen after initial crizotinib treatment.