Glutamate is an excitatory relative of GABA. It is the most common neurotransmitter in the central nervous system-as much as half of all neurons in the brain-and is especially important in regards to memory.Curiously, glutamate is actually toxic to neurons, and an excess will kill them.t is an inhibitory neurotransmitter, meaning that when it finds its way to its receptor sites, it blocks the tendency of that neuron to fire. Dopamine is strongly associated with reward mechanisms in the brain. Drugs like cocaine, opium, heroin, and alcohol increase the levels of dopamine, as does nicotine.
Causes of Muscle weakness. Muscle weakness may be caused by a variety of diseases and conditions, including low sodium or potassium, amyotrophic lateral sclerosis, cerebral palsy, multiple sclerosis, pinched nerve, muscular dystrophy and poisoning.uscle weakness may be caused by a variety of diseases and conditions, including low sodium or potassium, amyotrophic lateral sclerosis, cerebral palsy, multiple sclerosis, pinched nerve, muscular dystrophy and poisoning.
Leg weakness can occur as part of a generalized feeling of weakness all over your body, or it may develop in one or both legs. True weakness occurs when the muscles lose their strength, but people often perceive that their muscles are weak when they feel ill or tired. In these cases there is not a true loss of muscle function. The sudden onset of muscle weakness can be a sign of stroke, a potentially life-threatening condition in which part of the brain is deprived of oxygen. This article focuses on conditions that cause a true loss of strength in the leg muscles. Among the most common causes for leg weakness is sciatica, problems with the spinal cord that lead to pinching or compression of the nerves as they exit the spinal cord through the holes between the vertebrae of the backbone.