Membranes contain large amounts of lipids, which are notoriously hydrophobic (water and oil don't mix). The membrane-spanning regions of membrane proteins are typically alpha helices, made of hydrophobic amino acids.
Florence, for example, hosted a brilliant period of musico-theatrical innovation at the dawn of the seventeenth century that led to the flowering of early opera. Rome continued to influence sacred music and for a time became an important center of opera, several types of vocal chamber music, and instrumental music. Venice, a leading musical city throughout the seventeenth century, nurtured the development of opera, as did Naples in the eighteenth century.
With it came the development of the modern concerto, symphony, sonata, trio and quartet to a new peak of structural and expressive refinement. If Baroque music is notable for its textural intricacy, then the Classical period is characterised by a near-obsession with structural clarity.