Patients were stratified according to tumor PD-L1 status assessed in a central laboratory by immunohistochemical testing (positive vs. negative or indeterminate), BRAF mutation status (V600 mutation-positive vs. wild-type) and American Joint Committee on Cancer stage.[Level of evidence: 1iiA]
Swallowing air excessively; Gastroesophageal reflux; Hiatus hernia; Rapid eating; Intense emotions such as fear, anxiety, excitement, joy, or euphoria [citation needed] Carbonated beverages, alcohol, dry breads, and some spicy foods; Opiate drug use; Laughing; Hiccups may be triggered by a number of common human conditions.
1 A hiccup is a sudden, involuntary contraction (spasm) of the diaphragm muscle. When the muscle spasms, the vocal cords snap shut, producing the hiccup sound. 2  Common causes of hiccups include: 3  eating too quickly, eating or drinking too much,  diseases that irritate the nerves that control the diaphragm,