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skeleton. 1  the hard framework of an animal body, supporting the tissues and protecting the organs; specif., all the bones collectively, or the bony framework, of a human being or other vertebrate animal. 2  anything like a skeleton in any of various ways a very lean or emaciated person or animal.
The human skeleton is the internal framework of the body. It is composed of 270 bones at birth â this total decreases to 206 bones by adulthood after some bones have fused together. The bone mass in the skeleton reaches maximum density around age 30. The human skeleton can be divided into the axial skeleton and the appendicular skeleton.