(April 2014) In law and government, de jure (/deÉª ËdÊÊrÉª/; Latin: de iure, in law) describes practices that are legally recognized by official laws. In contrast, de facto (in fact or in practice) describes situations that are generally known to exist in reality, even if not legally authorized.
Only a portion of them are chromosome abnormalities. Single gene disorders are conditions that are caused by a change in a single gene. Because there are thousands of genes, there are thousands of single gene disorders. This group of disorders cannot be diagnosed by a karyotype.
A karyotype analysis can be used to determine if individuals have abnormal numbers of chromosomes or abnormal-sized chromosomes. 1  These abnormalities can be due to: 2  Nondisjunction: chromosomes did not separate in parental cells, leading to children that have too many or too few copies of chromosomes.