(April 2014) In law and government, de jure (/deÉª ËdÊÊrÉª/; Latin: de iure, in law) describes practices that are legally recognized by official laws. In contrast, de facto (in fact or in practice) describes situations that are generally known to exist in reality, even if not legally authorized.
Only a portion of them are chromosome abnormalities. Single gene disorders are conditions that are caused by a change in a single gene. Because there are thousands of genes, there are thousands of single gene disorders. This group of disorders cannot be diagnosed by a karyotype.
The work took place in 1955, and was published in 1956. The karyotype of humans includes only 46 chromosomes. Rather interestingly, the great apes have 48 chromosomes. Human chromosome 2 is now known to be a result of an end-to-end fusion of two ancestral ape chromosomes.