Now as to some of the ties, they will need to show that they have significant close family at home, property not easily sold, and a good job for a good company that they have had for awhile that a person would not normally abandon. So if the person is young, without much money or any property, they could be denied.
A mutation can occur anywhere in the body in a cellular level, but mainly if it is a disease, such as a hereditary one, it is usually in the DNA.
A missense mutation occurs when one DNA nucleotide is changed so that a different amino acid is inserted into a protein. Nucleotides are the repeating units of a DNA sequence. There are four nucleotides, each with different nitrogenous bases: thymine (T), adenine (A), guanine (G), and cytosine (C).