(April 2014) In law and government, de jure (/deÉª ËdÊÊrÉª/; Latin: de iure, in law) describes practices that are legally recognized by official laws. In contrast, de facto (in fact or in practice) describes situations that are generally known to exist in reality, even if not legally authorized.
Only a portion of them are chromosome abnormalities. Single gene disorders are conditions that are caused by a change in a single gene. Because there are thousands of genes, there are thousands of single gene disorders. This group of disorders cannot be diagnosed by a karyotype.
Make a Karyotype. A karyotype is an organized profile of a person's chromosomes. Two chromosomes specify gender  XX for female and XY for male. The rest are arranged in pairs, numbered 1 through 22, from largest to smallest. This arrangement helps scientists quickly identify chromosomal alterations that may result in a genetic disorder.