Toradol (ketorolac): Was given an im injection in the buttocks for migraines and it was completely ineffective. The pain that the injection caused was infuriating considering there was absolutely no relief of the headache..
Examples of full agonists are oxycodone, methadone, codeine, heroin and morphine. PARTIAL AGONISTS. Partial agonists are drugs that bind primarily to mu opioid receptors and cause them to produce endorphins but to a much lesser extent than full agonists. BuprenorphineÂ®, SuboxoneÂ® and SubutexÂ® are partial agonists.
Codeine is not itself centrally active, and must first be converted via first pass metabolism into morphine by the cytochrome P450 enzyme CYP2D6. Codeine is also metabolised into the inactive norcodeine via the CYP3A4 enzyme system.