Toradol (ketorolac): Was given an im injection in the buttocks for migraines and it was completely ineffective. The pain that the injection caused was infuriating considering there was absolutely no relief of the headache..
Examples of full agonists are oxycodone, methadone, codeine, heroin and morphine. PARTIAL AGONISTS. Partial agonists are drugs that bind primarily to mu opioid receptors and cause them to produce endorphins but to a much lesser extent than full agonists. BuprenorphineÂ®, SuboxoneÂ® and SubutexÂ® are partial agonists.
Norcodeine also has a similar affinity to codeine for the mu opioid receptor [Article: 8818573 ]. Between 0-15% of codeine is O-demethylated to morphine, the most active metabolite, which has 200 fold greater affinity for the mu opioid receptor compared to codeine.