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G proteins are molecular switches that are activated by receptor-catalyzed GTP for GDP exchange on the G protein alpha subunit, which is the rate-limiting step in the activation of all downstream signaling.eterotrimeric G proteins couple the activation of heptahelical receptors at the cell surface to the intracellular signaling cascades that mediate the physiological responses to extracellular stimuli.
Another synergistic action of GABA is manifested by the activation of GABA (B) receptors localized on postsynaptic sites. Binding of GABA to these receptors leads to the activation of G-protein activated Inward Rectifier K + (GIRK or K ir 3) channel 6, hyperpolarization and postsynaptic inhibition 1.n the postsynaptic membrane, GABA (B) receptors activate K + channels and induce slow inhibitory postsynaptic potentials that inhibit GABA (A) receptor activity. Receptors on extrasynaptic membranes are probably activated by a GABA overflow from nearby synapses.Adapted from reference 5 with permission of Elsevier.