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Pagetâs disease causes bones to grow too large and weak. You can have Pagetâs disease in any bones in your body, but most people have it in their spine, pelvis, skull, or leg bones. The disease may affect only one bone or several bones, but it does not affect the entire skeleton.f you have Pagetâs disease in your leg bones, you may also have bowed legs. Your spine might curve if the disease is in the bones of the spine. People with Pagetâs disease in the bones of the skull sometimes have: 1  Headaches. 2  Hearing loss. 3  Large head size.
Osteoporosis, or porous bone, is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased risk of fractures of the hip, spine, and wrist. Men as well as women are affected by osteoporosis, a disease that can be prevented and treated. Characterized by an irrational fear of weight gain, this eating disorder increases your risk for osteoporosis. 2  Calcium and vitamin D intake. 3  A lifetime diet low in calcium and vitamin D makes you more prone to bone loss.