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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
The major city closest to the halfway point between Asheville, NC and Charleston, SC is Columbia, SC, situated 157.68 miles from Asheville, NC and 114.23 miles from Charleston, SC. It would take 2 hours 12 mins to go from Asheville to Columbia and 1 hour 40 mins to go from Charleston to Columbia.