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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
Driving from Raleigh, NC to Columbia, SC is about a 3.5 hour drive. I recently moved to Raleigh from Columbia and after all the trips back and forth. You can go 2 ways to get there which I prefer to take I40 to I95S to I20W to Columbia, it's more scenic or you can go I85 towards Charlotte and pick up I77 to Columbia.