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Cholecystokinin is secreted by I-cells in the small intestine and induces contraction of the gall bladder, relaxes the sphincter of Oddi, reduces of gastric acid secretion, increases bile acid production in the liver, delays gastric emptying, and induces digestive enzyme production in the pancreas.
Gallstones form in the gallbladder due mainly to dietary or hormonal imbalances, but also from liver and gallbladder disease. When stones get caught in the bile ducts leading to the intestine, this prevents the release of bile and triggers inflammation and diffuse pain. Stabbing and/or burning upper abdominal pain, nausea, vomiting and belching are common symptoms of a gallbladder attack.