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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
How long does it take to drive from Charleston SC to Columbia SC? It is 114.12 miles and requires an estimated driving time of 1 hour and 56 minutes according to MapQuest.iven is the calculated distance as well as the driving travel time, which does not take into account driving conditions, traffic, etc. The distance between Alabama and Greenv â¦ ille, South Carolina is 346 miles. The resulting travel time is 5 hours and 35 minutes.