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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
Columbia is located in Richland County, SC. The population is 131,303, making Columbia the largest city in Richland County and the 2nd largest city in the state of South Carolina. There are 79 public schools in Columbia with an average Homefacts rating of C+.