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Cholecystokinin is secreted by I-cells in the small intestine and induces contraction of the gall bladder, relaxes the sphincter of Oddi, reduces of gastric acid secretion, increases bile acid production in the liver, delays gastric emptying, and induces digestive enzyme production in the pancreas.
Symptoms arise when a gallstone blocks the flow of bile out of the gallbladder or through the bile ducts. A gallstone in the common bile duct is called choledocholithiasis and may cause intermittent or constant discomfort.ccasionally the gallstones can also block the flow of digestive enzymes from the pancreas because both the bile ducts and pancreas ducts drain through the same small opening (called the Ampulla of Vater) which is held tight by a small circular muscle (called the Sphincter of Oddi).