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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
215 miles or 346 kilometers Driving distance from Columbia, SC to Atlanta, GA. The total driving distance from Columbia, SC to Atlanta, GA is  215 miles or 346 kilometers. Your trip begins in Columbia, South Carolina. It ends in Atlanta, Georgia.