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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
What is the distance between Charleston AND Columbia? The distance between Charleston and Columbia in a straight line is 106 miles or 170.55 Kilometers Driving Directions & Drive Times from Charleston to Columbia can be found further down the page. Driving distances, maps and journey times are currently provided by Google mapping systems.