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Cholecystokinin is secreted by I-cells in the small intestine and induces contraction of the gall bladder, relaxes the sphincter of Oddi, reduces of gastric acid secretion, increases bile acid production in the liver, delays gastric emptying, and induces digestive enzyme production in the pancreas.
Gallstones can cause symptoms if they become caught in the narrow outlet of the gallbladder, or in the ducts that drain the gallbladder. After meals, especially meals high in fat, thin muscles in the wall of the gallbladder squeeze to help release bile into the intestines.