Glutamate is an excitatory relative of GABA. It is the most common neurotransmitter in the central nervous system-as much as half of all neurons in the brain-and is especially important in regards to memory.Curiously, glutamate is actually toxic to neurons, and an excess will kill them.t is an inhibitory neurotransmitter, meaning that when it finds its way to its receptor sites, it blocks the tendency of that neuron to fire. Dopamine is strongly associated with reward mechanisms in the brain. Drugs like cocaine, opium, heroin, and alcohol increase the levels of dopamine, as does nicotine.
Causes of Muscle weakness. Muscle weakness may be caused by a variety of diseases and conditions, including low sodium or potassium, amyotrophic lateral sclerosis, cerebral palsy, multiple sclerosis, pinched nerve, muscular dystrophy and poisoning.uscle weakness may be caused by a variety of diseases and conditions, including low sodium or potassium, amyotrophic lateral sclerosis, cerebral palsy, multiple sclerosis, pinched nerve, muscular dystrophy and poisoning.
Muscle atrophy, often seen in people in wheelchairs, can lead to leg weakness. The power and ability to move one's legs stems from the interaction of two processes. These are the nerve signal that is sent to the muscles from the brain and passes via the spinal cord, and the muscle's intrinsic power to contract. Any interruption in this pathway in the lower limb can result in leg weakness. As such, leg weakness can be caused by a muscle disease or a nerve disease.