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skeleton. 1  the hard framework of an animal body, supporting the tissues and protecting the organs; specif., all the bones collectively, or the bony framework, of a human being or other vertebrate animal. 2  anything like a skeleton in any of various ways a very lean or emaciated person or animal.
bone. 1. The hard, dense, calcified tissue that forms the skeleton of most vertebrates. Bone serves as a framework for the attachment of muscles and protects vital organs, such as the brain. It also contains large amounts of calcium, a mineral that is essential for proper cell function.Blood cells and platelets are produced in the marrow, the central cavity of bone.See more at osteoblast, osteocyte.. An animal structure or material, such as ivory, resembling bone. 4. Something made of bone or of material resembling bone, especially: a. A piece of whalebone or similar material used as a corset stay.