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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
Directions: From Columbia, take I-26 W to exit 28 toward Spartanburg on US 221 N. Travel 2.6 miles and take a sharp right onto SC Hwy 215/Stone Station Road. Turn left to stay on SC Hwy 215/Stone Station Road after another 2.6 miles.