steve.kubeny@state.mn.us: Jody Derks: Fisheries specialist: 218-739-7576: jody.derks@state.mn.us: Mike Nelson: Fisheries techniian: 218-739-7576: mike.nelson@state.mn.us: Ron Erickson: Fisheries technicia: 218-739-7576: ron.erickson@state.mn.us: Kate Baldwin: Office administrative specialist: 218-739-7576: kate.baldwin@state.mn.us
Experts describe gluconeogenesis as the process by which the liver contributes to the maintenance of normal blood glucose levels (and thus energy metabolism) through synthesis of glucose. This process occurs in the fasting state, such as at night, and requires the presence of amino acids, lactate, and glycerol.
For example, the pathway leading from phosphoenolpyruvate to glucose-6-phosphate requires 6 molecules of ATP. Gluconeogenesis is often associated with ketosis. Gluconeogenesis is also a target of therapy for type II diabetes, such as metformin, which inhibits glucose formation and stimulates glucose uptake by cells.