Now as to some of the ties, they will need to show that they have significant close family at home, property not easily sold, and a good job for a good company that they have had for awhile that a person would not normally abandon. So if the person is young, without much money or any property, they could be denied.
A mutation can occur anywhere in the body in a cellular level, but mainly if it is a disease, such as a hereditary one, it is usually in the DNA.
A mutation occurs whenever there is a change in the genetic information of an organism, due to a variety of causes. There are two classes of mutation: point mutations, and frameshift mutations (Some texts and professors classify frameshift as point mutations; others see it as such a different event with drastically different.