Causes and Risk Factors. Diffuse esophageal spasms can be caused by disruptions or damage to the nerves that coordinate the muscles of the esophagus. In some cases, this condition can lead to. achalasia.he esophagus is a muscular tube that connects the mouth to the stomach. During swallowing, it contracts in a coordinated way to move food or liquid to the stomach. Diffuse esophageal spasm causes the esophagus to contract in an uncoordinated way. As a result, what is swallowed is not pushed down into the stomach.
Other neurons heavily involved in controlling sleep and wakefulness belong to the in the brainstem. By diffusing their neuromodulating substances throughout wide areas of the brain, the neurons in these systems act as switches that adjust the cortexâs sensitivity to sensory information.
Another neurotransmitter, serotonin, is also released in the brain throughout the day, which has the effect of stimulating a particular area in the hypothalamus, which in turn inhibits a different part of the same organ, all of which has the effect of encouraging sleep.