Now as to some of the ties, they will need to show that they have significant close family at home, property not easily sold, and a good job for a good company that they have had for awhile that a person would not normally abandon. So if the person is young, without much money or any property, they could be denied.
A mutation can occur anywhere in the body in a cellular level, but mainly if it is a disease, such as a hereditary one, it is usually in the DNA.
In biology, a mutation is a permanent change of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements. DNA damage can cause an error when the DNA is replicated, and this error of replication can cause a gene mutation that, in turn, could cause a genetic disorder. DNA damages are repaired by the DNA repair system of the cell.