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Ganglion Cyst Quick Overview. A ganglion cyst is a tumor or swelling (benign, not cancerous) usually on top of a joint or the covering of a tendon (tissue that connects muscle to bone). It looks like a sac of liquid (cyst) located just under the skin. Inside the cyst is a thick, sticky, clear, colorless, jellylike material.
Ganglion cysts develop in the tissues near joints and tendons, often in the wrists or ankles. They also can occur behind the knees, in which case they are known as Baker's cysts. This type of cyst usually is filled with a thicker fluid than skin cysts. A ganglion cyst causes painful swelling.