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He says, as a guess, a drug screen would probably show something for most steroids, even 40 days later. That stuff stays in your system a long time. Think about what its purpose is.It's there to produce growth in different organs and stuff in the body, so it's there for a while, he said.e says, as a guess, a drug screen would probably show something for most steroids, even 40 days later. That stuff stays in your system a long time. Think about what its purpose is.
Add your answer. How long does a steroid pack (such as methylprednisolone) stay in your system? My doctor prescribed a 21-tablet, 4MG pack for a busted up shoulder I had and I do notice some of the minor side effects -- weight gain and a change of location where the weight is stored and excess sweating.