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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
Planes and Trains. The international airport at Greenville/Spartanburg is 45 minutes (45 miles) from Clemson. This airport is serviced by Allegiant Air, American Airlines, Delta, Southwest, United and US Airways. The airports in Atlanta and Charlotte are each about a two-hour drive from the University.