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The important point is that the surface area to the volume ratio gets smaller as the cell gets larger. Thus, if the cell grows beyond a certain limit, not enough material will be able to cross the membrane fast enough to accommodate the increased cellular volume. When this happens, the cell must divide into smaller cells with favorable surface area/volume ratios, or cease to function. That is why cells are so small.
what happens when glycolysis generates large amounts of ATP? it fills all of the available NAD+ molecules with electrons and without oxygen the electron transport chain cannot run so the carriers cannot move the electrons out of the cell and ultimately no more NAD+ is generated so ATP production stops. when does fermentation come into use.