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Quoting this article Efficacy, effectiveness, efficiency, 1  efficacy is the extent to which a drug has the ability to bring about its intended effect under ideal circumstances, such as in a randomised clinical trial. 2  effectiveness is the extent to which a drug achieves its intended effect in the usual clinical setting.
Potency versus Efficacy. The term commonly used is efficacy-in other words, if two drugs occupy the same number of receptors on a tissue, and one drug elicits a greater biological response than the other drug (by its action on the receptor) then that drug has greater efficacy.otency versus Efficacy. The term commonly used is efficacy-in other words, if two drugs occupy the same number of receptors on a tissue, and one drug elicits a greater biological response than the other drug (by its action on the receptor) then that drug has greater efficacy.