Despite Moltke's disdain for America's military efforts during the Civil War, the U.S. Army can learn. a great deal about how advances in technology can change the nature of war. The conduct of war. changed as a result of three technological advances during the Civil War: the rifled musket, the. electric telegraph, and the railroad.
The idea which emerges from this is that a strong nucleophile can attack directly, without help from an acid catalyst. For a weak nucleophile, an acid catalyst is needed so that the carbonyl carbon is prepared to share a pair of electrons as a new covalent bond.If we look at the mechanism of reaction between an aldehyde and an amine, we see how these factors balance.he idea which emerges from this is that a strong nucleophile can attack directly, without help from an acid catalyst. For a weak nucleophile, an acid catalyst is needed so that the carbonyl carbon is prepared to share a pair of electrons as a new covalent bond.
In these reductions, hydrogen atoms are added to the carbonyl carbon and to the carbonyl oxygen. Since there is no hint of acid present, these reactions resemble base-catalyzed addition of water, addition of HCN, and the addition of a Grignard reagent rather than acid catalyzed reactions.