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A: Zyrtec-D is a combination tablet of an antihistamine (Zyrtec) and a decongestant (pseudoephedrine). Antihistamines help with sneezing, runny noses and drainage. Decongestants help relieve pressure and pain in the sinuses. Zyrtec or the antihistamine portion has a potential to cause some drowsiness and dry mouth. Sudafed (pseudoephedrine) can cause difficulty sleeping, nausea, and loss of appetite.
Both Zyrtec and Claritin may make you drowsy or tired. For that reason, you shouldnât take these medications if you also take muscle relaxers, sleeping pills, or other drugs that cause drowsiness. Taking them at the same time that you take sedating drugs can make you extremely sleepy.