Excitatory synapses. The neurotransmitter at excitatory synapses depolarizes the postsynaptic membrane (of a neuron in this diagram). 1  Binding of acetylcholine to its receptors on the postsynaptic cell opens up ligand-gated sodium channels. 2  These allow an influx of Na + ions, reducing the membrane potential.xcitatory synapses. The neurotransmitter at excitatory synapses depolarizes the postsynaptic membrane (of a neuron in this diagram). 1  Binding of acetylcholine to its receptors on the postsynaptic cell opens up ligand-gated sodium channels. 2  These allow an influx of Na + ions, reducing the membrane potential.
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