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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
How far is columbia sc from charleston sc? In South Carolina, the city of Columbia is 105 miles away from the city of Charleston. This distance takes approximately two hours to drive, using the fastest route. Edit