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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
Map of driving directions from Greenville, SC to Columbia, SC. Click here to show map. Drag the line on the map to calculate the driving distance for a different route. If you want to verify these driving directions or look for another possible route, you can try. Google Maps, Bing Maps, or MapQuest.