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1 Lipids are relatively insoluble in water. 2  They are soluble in non-polar solvents, like ether, chloroform, methanol. 3  Lipids have high energy content and are metabolized to release calories.4  Lipids also act as electrical insulators, they insulate nerve axons.haracteristics of Lipids. 1  Lipids are relatively insoluble in water. 2  They are soluble in non-polar solvents, like ether, chloroform, methanol. 3  Lipids have high energy content and are metabolized to release calories.
The greater the lipid solubility, the more readily a molecule will pass through the membrane, i.e., the greater will be the flux for a given concentration difference Water soluble, lipid-insoluble substances by definition cannot pass through membranes by dissolving in the lipids.t is called the hydrophilic, or water-loving, portion of the lipid molecule. In contrast, the two tails of each lipid molecule are non-polar and water insoluble. They are composed of long-chain fatty acids which are hydrophobic, or water-hating, in nature.