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skeleton. 1  the hard framework of an animal body, supporting the tissues and protecting the organs; specif., all the bones collectively, or the bony framework, of a human being or other vertebrate animal. 2  anything like a skeleton in any of various ways a very lean or emaciated person or animal.
The human skeleton is the internal framework of the body. It is composed of 270 bones at birth â this total decreases to 206 bones by adulthood after some bones have fused together. The bone mass in the skeleton reaches maximum density around age 30.