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The centromere is the part of a chromosome that links a pair of sister chromatids. During mitosis, spindle fibers attach to the centromere via the kinetochore. Centromeres were first thought to be genetic loci that direct the behavior of chromosomes. The physical role of the centromere is to act as the site of assembly of the kinetochores â a highly complex multiprotein structure that is responsible for the actual events of chromosome segregation â i.e. binding microtubules and ...
Centromere is replicated... sister chromatids separate and move toward opposite poles (each with its own centromere) (now called daughter chromosomes) The kinetochore (proteins attached the the centromere) pulls the chromatids along spindly fiber ( special proteins on the spindle fibers.