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skeleton. 1  the hard framework of an animal body, supporting the tissues and protecting the organs; specif., all the bones collectively, or the bony framework, of a human being or other vertebrate animal. 2  anything like a skeleton in any of various ways a very lean or emaciated person or animal.
endoskeletonnoun [ C ] uk â /Ëen.dÉÊËskel.É.tÉn/ us â /Ëen.doÊËskel.É.tÌ¬Én/ specialized. â. âº a hard frame that supports the body of a vertebrate animal on the inside, made of bone or cartilage (= strong tissue) Compare.