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The major glands of the endocrine system are the pineal gland, pituitary gland, thyroid and parathyroid glands, adrenal glands, pancreas, thymus, ovaries, and testes. There are also other organs in the body that have secondary endocrine functions.These organs include the heart, liver, and kidneys. Hormones can be regulated by other hormones, by glands and organs, and by a negative feedback mechanism. In negative feedback, the initial stimulus is reduced by the response it provokes.he major glands of the endocrine system are the pineal gland, pituitary gland, thyroid and parathyroid glands, adrenal glands, pancreas, thymus, ovaries, and testes. There are also other organs in the body that have secondary endocrine functions.
  Hormones are produced only by the endocrine glands, e.g., the pituitary, the adrenals, etc.. Hormones are chemical messengers: they are sent by the glands to â¦ target organs and stimulate them to produce specific effects, e.g. the hormone thyroxin is manufactured by the thyroid gland to regulate the metabolism.