Now as to some of the ties, they will need to show that they have significant close family at home, property not easily sold, and a good job for a good company that they have had for awhile that a person would not normally abandon. So if the person is young, without much money or any property, they could be denied.
A mutation can occur anywhere in the body in a cellular level, but mainly if it is a disease, such as a hereditary one, it is usually in the DNA.
Somatic mutations may occur in any cell division from the first cleavage of the fertilized egg to the cell divisions that replace cells in a senile individual. The mutation affects all cells descended from the mutated cell.