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Pagetâs disease causes bones to grow too large and weak. You can have Pagetâs disease in any bones in your body, but most people have it in their spine, pelvis, skull, or leg bones. The disease may affect only one bone or several bones, but it does not affect the entire skeleton.f you have Pagetâs disease in your leg bones, you may also have bowed legs. Your spine might curve if the disease is in the bones of the spine. People with Pagetâs disease in the bones of the skull sometimes have: 1  Headaches. 2  Hearing loss. 3  Large head size.
1 Although your bones stop growing when you are around 20, they do constantly rebuild new bone cells. 2  The spine is made up of 33 bones. 3  Red bone marrow can produce around 5 billion red blood cells each day. 4  Very few man made substances can come close to the lightness and strength of bones.