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Driving distance from Greenville, SC to Columbia, SC. The total driving distance from Greenville, SC to Columbia, SC is 104 miles or 167 kilometers. Your trip begins in Greenville, South Carolina. It ends in Columbia, South Carolina.
If you're planning a road trip, you might be interested in seeing the total driving distance from Columbia, SC to Charlotte, NC. You can also calculate the cost to drive from Columbia, SC to Charlotte, NC based on current local gas prices and an estimate of your car's best gas mileage. If you're meeting a friend, you might be interested in finding the city that is halfway between Columbia, SC and Charlotte, NC.