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Pagetâs disease causes bones to grow too large and weak. You can have Pagetâs disease in any bones in your body, but most people have it in their spine, pelvis, skull, or leg bones. The disease may affect only one bone or several bones, but it does not affect the entire skeleton.f you have Pagetâs disease in your leg bones, you may also have bowed legs. Your spine might curve if the disease is in the bones of the spine. People with Pagetâs disease in the bones of the skull sometimes have: 1  Headaches. 2  Hearing loss. 3  Large head size.
What is Pagetâs Disease? Paget's disease of the bone occurs when bones become too large and weak due to an error in the normal process of bone breakdown and rebuilding. The disease may affect any bone in the body, but it often tends to affect the bones of the pelvis (the area between the stomach and thighs) and legs.