Patients were stratified according to tumor PD-L1 status assessed in a central laboratory by immunohistochemical testing (positive vs. negative or indeterminate), BRAF mutation status (V600 mutation-positive vs. wild-type) and American Joint Committee on Cancer stage.[Level of evidence: 1iiA]
Swallowing air excessively; Gastroesophageal reflux; Hiatus hernia; Rapid eating; Intense emotions such as fear, anxiety, excitement, joy, or euphoria [citation needed] Carbonated beverages, alcohol, dry breads, and some spicy foods; Opiate drug use; Laughing; Hiccups may be triggered by a number of common human conditions.
Hiccups occur when a spasm contracts the diaphragm, a large sheet of muscle that separates the chest cavity from the abdominal cavity. This spasm causes an intake of breath that is suddenly stopped by the closure of the vocal cords (glottis).This closure causes the characteristic hiccup sound.oth persistent and intractable hiccups may be a sign of a more serious health problem and must be checked by a doctor. There are many known causes of persistent or intractable hiccups, including: 1  Central nervous system problems, such as cancer, infections, stroke, or injury.