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Oxidation is defined as the interaction between oxygen molecules and all the different substances they may contact, from metal to living tissue. Technically, however, with the discovery of electrons, oxidation came to be more precisely defined as the loss of at least one electron when two or more substances interact.
What is the difference between oxidation and reduction? Quick Answer. Oxidation reactions occur when the reactant loses electrons and may involve the addition of oxygen or the loss of hydrogen, while reduction reactions occur when the reactant gains electrons and may involve the loss of oxygen or the addition of hydrogen.