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The important point is that the surface area to the volume ratio gets smaller as the cell gets larger. Thus, if the cell grows beyond a certain limit, not enough material will be able to cross the membrane fast enough to accommodate the increased cellular volume. When this happens, the cell must divide into smaller cells with favorable surface area/volume ratios, or cease to function. That is why cells are so small.
You see, mature red blood cells don't grow, they don't divide, and they don't make any new proteins. If a cell doesn't make new proteins or divide, it also doesn't need ribosomes to translate RNA into proteins, and it doesn't need DNA for transcription or replication, which makes DNA and the nucleus unnecessary.Red blood cells also use very little energy, which makes the mitochondria unnecessary.fter all, red blood cells have to come from somewhere, and cells do need mitochondria and a nucleus with DNA to go through mitosis, make new cells, and make all of that hemoglobin protein. As it turns out, immature red blood cells do have mitochondria and a nucleus for just those reasons.