High anion gap metabolic acidosis. High anion gap metabolic acidosis is a form of metabolic acidosis characterized by a high anion gap (a medical value based on the concentrations of ions in a patient's serum). An anion gap is usually considered to be high if it is over 11 mEq/L.
Leukemia (American English) or leukaemia (British English) is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells. These white blood cells are not fully developed and are called blasts or leukemia cells.he exact cause of leukemia is unknown. Different kinds of leukemia are believed to have different causes. Both inherited and environmental (non-inherited) factors are believed to be involved. Risk factors include smoking, ionizing radiation, some chemicals (such as benzene), prior chemotherapy, and Down syndrome.
This protein causes CML cells to grow and reproduce out of control. In a very small number of CML patients, the leukemia cells have the BCR-ABL oncogene but not the Philadelphia chromosome. It is thought that the BCR-ABL gene must form in a different way in these people.uring the past few years, scientists have made great progress in understanding how certain changes in DNA can cause normal bone marrow cells to become leukemia cells. In no cancer is this better understood than in chronic myeloid leukemia (CML). Each human cell contains 23 pairs of chromosomes.