Pleiotropy. Pleiotropy is the phenomenon whereby a single gene has multiple consequences in numerous tissues. Pleiotropic effects stem from both normal and mutated genes, but those caused by mutations are often more noticeable and easier to study.leiotropy. Pleiotropy is the phenomenon whereby a single gene has multiple consequences in numerous tissues. Pleiotropic effects stem from both normal and mutated genes, but those caused by mutations are often more noticeable and easier to study.
An evaluation instrument is typically a questionnaire, an interview script, or a set of observation guidelines, used to evaluate one or more aspects of an intervention in the drugs field.nstruments are generally classed according to the intervention field they are designed to be used in (treatment, prevention, or harm reduction), though some instruments may be usable in more than one field.
Instrument developers can evaluate and analyze the performance of individuals on each. item by conducting the interview, using item scale correlation to assess correlation. among items (Field, 2000), coefficient alpha to measure the internal consistency or. reliability for scale items (Oppenheim; 1992).