fourthyearmed Senior Member 5+ Year Member. Yes, 3rd year is long, hard, a lot of work, and has tests but I still enjoyed it so much more than the HELL that was 1st and 2nd years. 3rd year involves interaction not just with patients but with other people in the medical field besides your classmates.
The mitotic spindle is the macromolecular machine that segregates chromosomes to two daughter cells during mitosis. The major structural elements of the spindle are microtubule polymers, whose intrinsic polarity and dynamic properties are critical for bipolar spindle organization and function.he mitotic spindle is the macromolecular machine that segregates chromosomes to two daughter cells during mitosis. The major structural elements of the spindle are microtubule polymers, whose intrinsic polarity and dynamic properties are critical for bipolar spindle organization and function.
In this way, the spindle in a mitotic cell has two poles emanating microtubules. Microtubules are long proteic filaments with asymmetric extremes, a minus(-) end relatively stable next to the centrosome, and a plus(+) end enduring alternate phases of growing-shrinking, exploring the center of the cell.n the other hand, MTs are metastable polymers made of Î±- and Î²-tubulin, alternating between growing and shrinking phases, a phenomenon known as dynamic instability. MTs are highly dynamic structures, whose behavior is integrated with kinetochore function to control chromosome movement and segregation.