The carrier frequency and incidence of alpha thalassemia vary by the type and population. Carrier frequency of this condition is reported to be the highest in individuals of Southeast Asian, African, West Indian, and Mediterranean descent.
Clitheroe Castle Museum is adjacent to the castle. The castle was listed as a Scheduled Monument on 10 April 1915 (and later, under the Ancient Monuments and Archaeological Areas Act 1979 law).It was Grade I listed on 19 May 1950.t has been suggested that Clitheroe Castle may have been first built before 1086 as there is reference to the  castellatu Rogerii pictaviensis  in the Domesday Book entry for nearby Barnoldswick. However, it is likely the passage refers to another castle.
Conwy Castle (Welsh: Castell Conwy, English: Conway Castle) is a medieval fortification in Conwy, on the north coast of Wales.It was built by Edward I, during his conquest of Wales, between 1283 and 1289.Constructed as part of a wider project to create the walled town of Conwy, the combined defences cost around Â£15,000, a huge sum for the period. Over the next few centuries, the castle played an important part in several wars.onwy Castle (Welsh: Castell Conwy, English: Conway Castle) is a medieval fortification in Conwy, on the north coast of Wales.