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Neutropenia is classified as mild, moderate, or severe, based on the ANC. Mild neutropenia is present when the ANC is 1000-1500 cells/ÂµL, moderate neutropenia is present with an ANC of 500-1000/ÂµL, and severe neutropenia refers to an ANC lower than 500 cells/ÂµL. The risk of bacterial infection is related to both the severity and duration of the neutropenia.
It is important to note that the severity ofillness may vary within families with the same geneticcause for neutropenia. Relatives of patients with verysevere neutropenia may have ANC levels of 0.5â1.5 109/L and relatively few symptoms and still have the sameunderlying genetic disease.