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TEXT. A number sign (#) is used with this entry because of evidence that familial hypertrophic cardiomyopathy-9 (CMH9) is caused by heterozygous mutation in the TTN gene (188840) on chromosome 2q31.2012) used next-generation sequencing to analyze the TTN gene in 203 individuals with dilated cardiomyopathy (CMD; see CMD1G, 604145), 231 with CMH, and 249 controls. The frequency of TTN mutations was significantly higher among individuals with CMD (27%) than among those with CMH (1%) or controls (3%).