Of or pertaining to James the First, of England, or of his reign or times; especially, pertaining to a style of architecture and decoration popular in the time of James I.; as, Jacobean writers. Etymology: From L. Jacobus James.
ALS is a progressive, degenerative disease of the nervous system. It is one of a group of diseases, called motor neuron diseases (MND), in which specialized nerve cells that control movement of the voluntary muscles gradually cease functioning and die. Fasciculation is a sign of muscle irritability, as the normal action of the lower motor neuron on the muscle is impaired. 2  The sole involvement of lower motor neurons can be seen in a form of ALS called progressive muscular atrophy.
Type I spinal muscular atrophy (also called Werdnig-Hoffman disease) is a severe form of the disorder that is evident at birth or within the first few months of life. Affected infants are developmentally delayed; most are unable to support their head or sit unassisted.MA-LED and the late-onset form of spinal muscular atrophy caused by VAPB gene mutations are inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. X-linked spinal muscular atrophy is inherited in an X-linked pattern.