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Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation.
Hypochromia is characterized by an increase in central pallor. It is said to be present when greater than 1/2 of the cell diameter has central pallor. Hypochromia is caused by a deficiency in the production of hemoglobin, which is usually the result of iron deficiency caused by chronic hemorrhage. Poikilocytes are frequent in iron-lack anemia and are thought to result from oxidation of the erythrocyte membrane resulting in fragmentation.