Diarrhea is a very common problem in children. Diarrhea is frequent, loose, or watery bowel movements (BMs) that differ from a childâs normal pattern. Sometimes diarrhea contains blood or mucus. Identifying mild diarrhea may be difficult because in healthy children, the number and consistency of BMs vary with age and diet.
Aspirin and nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs) inhibit platelet cyclooxygenase, thereby blocking the formation of thromboxane A2. These drugs produce a systemic bleeding tendency by impairing thromboxane-dependent platelet aggregation and consequently prolonging the bleeding time.
Vasopeptidase inhibitors (VPIs) are a new class of cardiovascular drugs that have the novel action of simultaneously inhibiting ACE and neutral endopeptidase (NEP) (Fig. 5). NEP catalyses the hydrolysis of atrial natriuretic peptide, brain natriuretic peptide and C-type natriuretic peptide.