cerebral cortex. The outer layer of gray matter that covers the cerebral hemispheres in the brain of many vertebrate animals and is composed of folds of nerve cells and fibers.erebral cortex. The outer layer of gray matter that covers the cerebral hemispheres in the brain of many vertebrate animals and is composed of folds of nerve cells and fibers.
Dopamine blockers and depletors are used to treat conditions that arise from the over-production or increased activity of dopamine. Dopamine blockers work by binding to and blocking the action of dopamine receptors.his prevents the receptors from using the dopamine that is present in the brain or elsewhere in the body. Conversely, dopamine depletors work by preventing dopamine from being stored or released by neurons. There are numerous types of dopamine blockers and depletors.
Dopamine itself is used as precursor in the synthesis of the neurotransmitter norepinephrine and the hormone epinephrine. Dopamine is converted into norepinephrine by the enzyme dopamine Î²-hydroxylase (DBH), with O 2 and L-ascorbic acid as cofactors.n the opposite direction, drugs that increase the effects of dopamine, such as cocaine or amphetamine, produce heightened levels of activity, including at the highest levels psychomotor agitation and stereotyped movements. The second important effect of dopamine is as a teaching signal.