Cramping or pain in a leg caused by poor blood circulation. This condition is frequently caused by hardening of the arteries (atherosclerosis). Intermittent claudication occurs only at certain times, usually after exercise, and is relieved by rest.
RESULTS: 22% (29/129) of respondents admitted to abusing gabapentinoids, and of these, 38% (11/29) abused gabapentinoids in order to potentiate the 'high' they obtained from methadone. CONCLUSIONS: Gabapentinoid abuse along with methadone has not previously been described.
Methadone works on parts of the brain and spinal cord to block the high caused by using opiates (such as heroin). It also helps reduce cravings and withdrawal symptoms caused by opiate use. The action of methadone is similar to other synthetic (man-made) medicines in the morphine category (opioids). Substances that are derived directly from the opium plant (such as heroin, morphine, and codeine) are known as opiates.