3. Blood Disorders. Blood disorders such as hemophilia and leukemia can cause unexplained bruising, often because your blood fails to clot properly. If you have severe and frequent unexplained bruising, it's a good idea to see a physician to rule out such disorders, especially if it seemed to come on suddenly.
Puffer fish contain the potent neurotoxin tetrodotoxin. TTX is thought to be synthesized by a bacterial or dinoflagellate species associated with the puffer fish. The toxin is concentrated in the liver, gonads, and skin. The level of toxicity is seasonal, and, in Japan, fugu is served only from October through March.
Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin. Lee CH(1), Ruben PC. Author information: (1)School of Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.Tetrodotoxin (TTX) is a potent toxin that specifically binds to voltage gated sodium channels.TTX binding physically blocks the flow of sodium ions through the channel, thereby preventing action potential (AP) generation and propagation.nteraction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin. Lee CH(1), Ruben PC. Author information: (1)School of Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.