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Liver Pain Causes. Causes of liver pain are not just a few but in fact quite a few owing to the importance of the organ. They give rise to liver pain of differing nature which may be categorized as acute or chronic liver pain, and sharp or dull liver pain. The causes can be listed as the following:-. 1  The most common cause of liver pain is a condition known as fatty liver, which is characterized by the excess accumulation of lipid molecules in the liver which causes it to swell. 2  Liver disorder of a chronic nature may be responsible for cirrhosis liver pain.
Researchers have noted that exhaustion and fatigue are the single most common symptom of liver damage, and it typically has a significant and damaging impact on the patientâs quality of life. Unfortunately, the specific causes of liver disease-related fatigue and exhaustion are not fully understood. Researchers speculate that the root cause of liver disease-related chronic fatigue may be caused by changes in brain chemistry and hormone levels which result from impaired liver function. In particular, altered levels of corticotropins, serotonin, and noradrenaline may be at the root of depleted energy levels.