Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules .
Some of the most common risk factors for heart failure include: 1  Age. 2  Hypertension. 3  Physical inactivity. 4  Diabetes. 5  Obesity. 6  Smoking. 7  Metabolic syndrome. 8  Family history of heart failure. 9  Enlargement of the left ventricle.
By Mayo Clinic Staff. Risk factors for developing heart disease include: 1  Age. Aging increases your risk of damaged and narrowed arteries and weakened or thickened heart muscle.  Sex. Men are generally at greater risk of heart disease. However, women's risk increases after menopause.