Of or pertaining to James the First, of England, or of his reign or times; especially, pertaining to a style of architecture and decoration popular in the time of James I.; as, Jacobean writers. Etymology: From L. Jacobus James.
ALS is a progressive, degenerative disease of the nervous system. It is one of a group of diseases, called motor neuron diseases (MND), in which specialized nerve cells that control movement of the voluntary muscles gradually cease functioning and die. Fasciculation is a sign of muscle irritability, as the normal action of the lower motor neuron on the muscle is impaired. 2  The sole involvement of lower motor neurons can be seen in a form of ALS called progressive muscular atrophy.
Atrophy resulting from disease of the tissue itself, or loss of trophic support due to other disease is termed pathological atrophy. Shrinkage in the size of the cell by loss of cell substance is known as atrophy. It represents a form of adaptive response and may culminate in cell death.ormonal and nerve inputs that maintain an organ or body part are referred to as trophic. Atrophy is a general physiological process of reabsorption and breakdown of tissues, involving apoptosis on a cellular level. It can be part of normal body development and homeostatic processes, or as a result of disease.