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Neutropenia is classified as mild, moderate, or severe, based on the ANC. Mild neutropenia is present when the ANC is 1000-1500 cells/ÂµL, moderate neutropenia is present with an ANC of 500-1000/ÂµL, and severe neutropenia refers to an ANC lower than 500 cells/ÂµL. The risk of bacterial infection is related to both the severity and duration of the neutropenia.
Tests for antineutrophil cytoplasmic antibodies (ANCA) may be used to: 1  Help detect and diagnose certain forms of autoimmune vasculitis, including granulomatosis with polyangiitis (Wegener granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg Strauss syndrome).ositive ANCA, PR3, and/or MPO tests help to support a diagnosis of systemic autoimmune vasculitis and to distinguish between different types. However, to confirm a diagnosis, a biopsy of an affected site is often required.