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Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation.
Paroxysmal Nocturnal Hemoglobinuria Causes. The main reason behind the occurrence of PNH is the mutation in the single stem cell gene named PIG-A. The gene is located on the X-chromosome in oneâs bone marrow. The exact reasons responsible for triggering this gene mutation are not known yet.