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Similar to heroin, oxycodone produces â along with pain management â a euphoric high caused by stimulation of the reward center of the brain. Oxycodone elevates levels of the neurotransmitter dopamine, which is considered the pleasure chemical of the brain. On the street, OxyContin is known as âOxy,â âOC,â âOxyCotton,â âHillbilly Heroin,â and âKickers,â and is often used if heroin or morphine is not available.
Cytochrome P450 3A4 Interaction. The concomitant use of OXYCONTIN with all cytochrome P450 3A4 inhibitors may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression.