When strict replication is enabled on the target DC (the receive one) it will not allow to replication for that update. When strict replication is disabled on the target DC (the receive one) it will request the full object from the source DC (the sending one) and apply the update.
The sharp pain in the thigh could be due to other potential diseases. These include osteomyelitis, Ewing's sarcoma, septic arthritis, osteosarcoma, sciatica, compartment syndrome, among other infections. It could also be because of a tumor in the bone, thigh bone fractures and nervous disorders like tendinitis.
Pain that is 'burning' is usually associated with injury to the nerves. Sometimes burning pain down the thigh is caused by something called meralgia paresthetica which refers to compression of one of the big sensory nerves to your legs. I don't know if that can cause pain all down to your ankle or not.