The carrier frequency and incidence of alpha thalassemia vary by the type and population. Carrier frequency of this condition is reported to be the highest in individuals of Southeast Asian, African, West Indian, and Mediterranean descent.
Clitheroe Castle Museum is adjacent to the castle. The castle was listed as a Scheduled Monument on 10 April 1915 (and later, under the Ancient Monuments and Archaeological Areas Act 1979 law).It was Grade I listed on 19 May 1950.t has been suggested that Clitheroe Castle may have been first built before 1086 as there is reference to the  castellatu Rogerii pictaviensis  in the Domesday Book entry for nearby Barnoldswick. However, it is likely the passage refers to another castle.
Conwy Castle (also known as Conway Castle) was built by Edward I in the thirteenth century. It was designed to watch over the walled town of Conwy and formed part of Edward Iâs plan to establish a new English colony on a significant Welsh site.Here are ten Conwy Castle facts.1  Conwy Castle was built between 1283 and 1287. 2  Construction of the Conwy town walls were constructed when the castle was nearing completion. 3  The castle and town were designed to function as one, the perimeter walls bonding the town to the castle.ere are ten Conwy Castle facts. 1  Conwy Castle was built between 1283 and 1287. 2  Construction of the Conwy town walls were constructed when the castle was nearing completion. 3  The castle and town were designed to function as one, the perimeter walls bonding the town to the castle.