Signs and symptoms of rebound headaches may differ according to the type of original headache being treated and the medication used. Rebound headaches tend to: Occur every day or nearly every day, often waking you in the early morning. Improve with pain relief medication but then return as your medication wears off.
Subsequently, propranolol became the first FDA-approved medication for the prevention of migraine. As one of many beta blockers used commonly to prevent migraine, propranolol currently, is probably the most widely prescribed medication in the world for prevention of migraine.
Fifty-three patients suffering from severe migraine attacks were given propranolol at low doses, close to or up to 1 mg/kg body weight daily, for one month. If the patient responded, then treatment was maintained unchanged for a further two months.