Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules .
Some of the most common risk factors for heart failure include: 1  Age. 2  Hypertension. 3  Physical inactivity. 4  Diabetes. 5  Obesity. 6  Smoking. 7  Metabolic syndrome. 8  Family history of heart failure. 9  Enlargement of the left ventricle.
These abnormal rhythms, especially if they are very frequent and fast, can weaken the heart muscle and cause heart failure. Complications. If you have heart failure, your outlook depends on the cause and the severity, your overall health, and other factors such as your age. Complications can include: Kidney damage or failure.