Hello Lisagarmaise, Serotonin is to blame! Excessive release of 5HT(serotonin) from intestinal mucosa cells can cause diarrhea and nausea. Metformin stimulates these intestinal cells to produce increased levels of 5HT, as soon as 10-15 minutes after taking metformin. The good news is that most symptoms dissapear after taking metformin for 2-3 weeks.
Progesterone, hormone secreted by the female reproductive system that functions mainly to regulate the condition of the inner lining (endometrium) of the uterus. Progesterone is produced by the ovaries, placenta, and adrenal glands.
Most hormones are secreted from endocrine glands. An endocrine gland is a ductless gland in which glandular cells secrete hormones directly into the bloodstream and interstitial fluid. Pancreas-is both and endocrine and exocrine gland. Exocrine glands are not part of the endocrine system.