Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules .
Some of the most common risk factors for heart failure include: 1  Age. 2  Hypertension. 3  Physical inactivity. 4  Diabetes. 5  Obesity. 6  Smoking. 7  Metabolic syndrome. 8  Family history of heart failure. 9  Enlargement of the left ventricle.
The most common causes of heart failure are: 1  coronary artery disease and heart attack (which may be silent) 2  cardiomyopathy. 3  high blood pressure (hypertension)  heart valve 1  disease. congenital heart disease.  alcoholism and drug abuse.