Cramping or pain in a leg caused by poor blood circulation. This condition is frequently caused by hardening of the arteries (atherosclerosis). Intermittent claudication occurs only at certain times, usually after exercise, and is relieved by rest.
RESULTS: 22% (29/129) of respondents admitted to abusing gabapentinoids, and of these, 38% (11/29) abused gabapentinoids in order to potentiate the 'high' they obtained from methadone. CONCLUSIONS: Gabapentinoid abuse along with methadone has not previously been described.
On the one hand, methadone is an opiate itself, binding to and activating mu-opioid receptors in the brain. It's this action which makes methadone a an opiate substitute that reduces cravings for harder opiates with more abuse potential, like heroin, morphine or fentanyl. Methadone does block the euphoric or mood-elevating effects of harder opiates. In other words, methadone activates mu-opioid receptors (just like morphine or heroin), but in a manner that doesn't elicit euphoria.