Diarrhea is a very common problem in children. Diarrhea is frequent, loose, or watery bowel movements (BMs) that differ from a childâs normal pattern. Sometimes diarrhea contains blood or mucus. Identifying mild diarrhea may be difficult because in healthy children, the number and consistency of BMs vary with age and diet.
Aspirin and nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs) inhibit platelet cyclooxygenase, thereby blocking the formation of thromboxane A2. These drugs produce a systemic bleeding tendency by impairing thromboxane-dependent platelet aggregation and consequently prolonging the bleeding time.
COMT inhibitor. COMT inhibitors block one of two ways levodopa can be inactivated before it reaches the central nervous system and is activated to dopamine. Peripheral inhibitors of DOPA decarboxylase (AADC) block the second way. (Dopamine in the periphery only causes side effects, no antiparkinson effect.)