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Neutropenia is classified as mild, moderate, or severe, based on the ANC. Mild neutropenia is present when the ANC is 1000-1500 cells/ÂµL, moderate neutropenia is present with an ANC of 500-1000/ÂµL, and severe neutropenia refers to an ANC lower than 500 cells/ÂµL. The risk of bacterial infection is related to both the severity and duration of the neutropenia.
Tests for antineutrophil cytoplasmic antibodies (ANCA) may be used to: 1  Help detect and diagnose certain forms of autoimmune vasculitis, including granulomatosis with polyangiitis (Wegener granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg Strauss syndrome).n addition, tests that are specific for antibodies to MPO and PR3 may be performed: 1  A positive test for PR3 antibodies and a positive cANCA or pANCA are seen in more than 80% of patients with active granulomatosis with polyangiitis (Wegener granulomatosis).