In HIT, the immune system forms antibodies against heparin when it is bound to a protein called platelet factor 4 (PF4). These antibodies are usually of the IgG class and their development usually takes about five days.
The first elevator shaft preceded the first elevator by four years. Construction for Peter Cooper's Cooper Union Foundation building in New York began in 1853. An elevator shaft was included in the design, because Cooper was confident that a safe passenger elevator would soon be invented.
Otis Elevator Company purchased Evans Lifts in the UK when Evans Lifts Ltd went bankrupt in 1997 during its merge with Express Lift Company with the name ExpressEvans. It was the oldest and largest manufacturer of lift equipment in the UK and was based in Leicester, England. Otis' Customer Care Centre is still based in the old Evans Lifts building in Leicester. The building has since been extended by Otis.