Diarrhea is a very common problem in children. Diarrhea is frequent, loose, or watery bowel movements (BMs) that differ from a childâs normal pattern. Sometimes diarrhea contains blood or mucus. Identifying mild diarrhea may be difficult because in healthy children, the number and consistency of BMs vary with age and diet.
Aspirin and nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs) inhibit platelet cyclooxygenase, thereby blocking the formation of thromboxane A2. These drugs produce a systemic bleeding tendency by impairing thromboxane-dependent platelet aggregation and consequently prolonging the bleeding time.
Platelet aggregation is the clustering together of thrombocytes, which are the small, cell-like structures made in the bone marrow that help prevent bleeding. This clumping can occur in response to many different agents, including the nucleotide adenosine diphosphate (ADP), and the proteins thrombin and collagen.