Diarrhea is a very common problem in children. Diarrhea is frequent, loose, or watery bowel movements (BMs) that differ from a childâs normal pattern. Sometimes diarrhea contains blood or mucus. Identifying mild diarrhea may be difficult because in healthy children, the number and consistency of BMs vary with age and diet.
Aspirin and nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs) inhibit platelet cyclooxygenase, thereby blocking the formation of thromboxane A2. These drugs produce a systemic bleeding tendency by impairing thromboxane-dependent platelet aggregation and consequently prolonging the bleeding time.
Drug-induced Thrombocytopenia. When drugs are the cause of low platelets, the disease is called drug-induced thrombocytopenia (DITP). In some cases, as in chemotherapy drugs, the drop in platelet count is due to changes in the bone marrow. In other cases antibodies can develop to both the drug and platelets at the same time, causing the platelets to drop. Sometimes drugs cause a combination of both bone marrow and immune problems.42.