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The replication fork is a structure that forms within the nucleus during DNA replication. It is created by helicases, which break the hydrogen bonds holding the two DNA strands together. The resulting structure has two branching prongs, each one made up of a single strand of DNA.
The method of replication is semi-conservative; this means that in the two daughter helices one strand of each is comprised of parental DNA (from the original helix), and the other is comprised of newly synthesised DNA. Synthesis occurs at the replication fork, our focus in this article.Replication is a complex process, involving many, many different enzymes-such as DNA polymerase-which have frustratingly similar names to enzymes in other processes.he method of replication is semi-conservative; this means that in the two daughter helices one strand of each is comprised of parental DNA (from the original helix), and the other is comprised of newly synthesised DNA. Synthesis occurs at the replication fork, our focus in this article.