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A follow-up test that measures free prostate-specific antigen (free PSA) may be used to see if a prostate biopsy should be done to check for cancer. Free PSA is the percent of prostate-specific antigen that is not attached to proteins in the blood. The lower a man's free PSA percentage, the more likely he is to have prostate cancer. A man with a total PSA between 4 and 10 ng/mL may have a test to find out his free PSA, to see if cancer is likely to be present.
A prostate-specific antigen (PSA) test measures the amount of prostate-specific antigen in the blood. PSA is released into a man's blood by his prostate gland. Healthy men have low amounts of PSA in the blood.The amount of PSA in the blood normally increases as a man's prostate enlarges with age. When combined with a digital rectal exam, the prostate-specific antigen (PSA) test may increase the chance of finding prostate cancer. 2  To learn more, see the topic Digital Rectal Examination (DRE) . 3  A PSA level within the normal ranges does not mean that prostate cancer is not present.