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Similar to heroin, oxycodone produces â along with pain management â a euphoric high caused by stimulation of the reward center of the brain. Oxycodone elevates levels of the neurotransmitter dopamine, which is considered the pleasure chemical of the brain. On the street, OxyContin is known as âOxy,â âOC,â âOxyCotton,â âHillbilly Heroin,â and âKickers,â and is often used if heroin or morphine is not available.
Long Term Effects. The most common long-term effect of abusing OxyContinÂ®, and perhaps the worst effect, is the addiction itself. Addiction ruins a personâs life bit by bit, becoming worse over time. In this way, OxyContinÂ® abuse is no different from heroin, cocaine, or alcohol abuse.ong-term physical effects of OxyContinÂ® abuse, or any opioid drug abuse, include: Painful Withdrawal that Maintains Addiction. 1  Restlessness. 2  Muscle and bone pain. 3  Muscle spasms. 4  Insomnia. 5  Diarrhea and vomiting. 6  Chills and goose bumps. 7  Intense anxiety.