Signs and symptoms of rebound headaches may differ according to the type of original headache being treated and the medication used. Rebound headaches tend to: Occur every day or nearly every day, often waking you in the early morning. Improve with pain relief medication but then return as your medication wears off.
Subsequently, propranolol became the first FDA-approved medication for the prevention of migraine. As one of many beta blockers used commonly to prevent migraine, propranolol currently, is probably the most widely prescribed medication in the world for prevention of migraine.
They are commonly used to treat conditions such as angina and high blood pressure. It was first noticed by chance that some people who were treated for angina, who also had migraine, found their migraine attacks (episodes) lessened when on propranolol. It is not clear how they work to prevent migraine.