Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules .
Some of the most common risk factors for heart failure include: 1  Age. 2  Hypertension. 3  Physical inactivity. 4  Diabetes. 5  Obesity. 6  Smoking. 7  Metabolic syndrome. 8  Family history of heart failure. 9  Enlargement of the left ventricle.
The more risk factors you have, and the greater the level of each risk factor, the higher your chance of developing coronary heart disease â a common term for the buildup of plaque in the heartâs arteries that could lead to heart attack. 1  Major risk factors. 2  Modifiable risk factors. 3  Contributing risk factors.