Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules .
Some of the most common risk factors for heart failure include: 1  Age. 2  Hypertension. 3  Physical inactivity. 4  Diabetes. 5  Obesity. 6  Smoking. 7  Metabolic syndrome. 8  Family history of heart failure. 9  Enlargement of the left ventricle.
Congestive Heart Failure (CHF) is caused by other diseases or conditions that damage or overwork the heart muscle; over time, the heart muscle is weakened. The leading causes of congestive heart failure are: 1  Coronary artery disease (CAD). 2  High blood pressure (hypertension). 3  Diabetes.