Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules .
Some of the most common risk factors for heart failure include: 1  Age. 2  Hypertension. 3  Physical inactivity. 4  Diabetes. 5  Obesity. 6  Smoking. 7  Metabolic syndrome. 8  Family history of heart failure. 9  Enlargement of the left ventricle.
Most people with heart failure also have high blood pressure, and about one out of every three people with heart failure also has diabetes. Other conditions and factors that can cause congestive heart failure include: 1  Cardiomyopathy (inflammation of the heart muscle). 2  Diseases of the heart valves.