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Neulasta side effects. Get emergency medical help if you have signs of an allergic reaction to Neulasta: hives, skin rash, flushing (warmth, redness, or tingly feeling); wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat. A rare but serious side effect of Neulasta is called capillary leak syndrome.
Neulasta is given once for each cycle of high-dose chemotherapy, at least 24 hours after chemo, and no sooner than 14 days before your next chemo infusion. Neupogen is given in several injections on a daily basis, until your neutrophil counts come back to normal levels.