Of or pertaining to James the First, of England, or of his reign or times; especially, pertaining to a style of architecture and decoration popular in the time of James I.; as, Jacobean writers. Etymology: From L. Jacobus James.
ALS is a progressive, degenerative disease of the nervous system. It is one of a group of diseases, called motor neuron diseases (MND), in which specialized nerve cells that control movement of the voluntary muscles gradually cease functioning and die. Fasciculation is a sign of muscle irritability, as the normal action of the lower motor neuron on the muscle is impaired. 2  The sole involvement of lower motor neurons can be seen in a form of ALS called progressive muscular atrophy.
If youâve been worried sick over the dent in your quad muscle, re-read Dr. Ruaneâs last line: âMuscles do not atrophy in small, defined sections that leave dents.â. Oddly, people who have hypochondria related to MS or ALS have somehow formulated the idea that an early sign of muscle atrophy is some little depression or groove in the muscle. Nowhere in the annals of medical literature is muscle denting named as a sign of wasting muscle tissue or atrophy, or any kind of disease. Another cause of the quad groove, in addition to local trauma, is a variation of this: prolonged leaning of the thigh into an object.