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Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation.
1 Diabetes insipidus can be caused by low or absent secretion of the water-balance hormone vasopressin from the pituitary gland of the brain, or by a poor kidney response to this chemical messenger, which is also called antidiuretic hormone.entral diabetes insipidus. Central diabetes insipidus-caused by a lowered or absent secretion of vasopressin-can be primary or secondary. 3. Primary central DI may have an unknown cause in many cases (idiopathic), or there is an abnormality of the gene responsible for vasopressin.