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It is difficult to tell. However, people have been burning up Twitter with tweets on the topic for days. Somebody even a fired up a Facebook page to add to the fun:  Make 4/21 National Drug Test Day .. With the motto Detox can't save ya now, the page has been liked by over 1,200 people.ecause there is no such holiday, officially or unofficially, as National Surprise Drug Test Day. No 4/21 to follow 4/20: National Pot Day, apparent fake holiday precursor.
1 Stay off of the drugs. 2  The easiest way to pass any drug test is to not use drugs of course. 3  In the case of a mouth swab drug test, this means not using for 24 to 72 hours, depending on the drug.4  Be careful about eating anything containing poppy seeds. The easiest way to pass any drug test is to not use drugs of course. 2  In the case of a mouth swab drug test, this means not using for 24 to 72 hours, depending on the drug. 3  Be careful about eating anything containing poppy seeds.