The carrier frequency and incidence of alpha thalassemia vary by the type and population. Carrier frequency of this condition is reported to be the highest in individuals of Southeast Asian, African, West Indian, and Mediterranean descent.
Clitheroe Castle Museum is adjacent to the castle. The castle was listed as a Scheduled Monument on 10 April 1915 (and later, under the Ancient Monuments and Archaeological Areas Act 1979 law).It was Grade I listed on 19 May 1950.t has been suggested that Clitheroe Castle may have been first built before 1086 as there is reference to the  castellatu Rogerii pictaviensis  in the Domesday Book entry for nearby Barnoldswick. However, it is likely the passage refers to another castle.
For example, when Tattershall Castle was built between 1430 and 1450, there was plenty of stone available nearby, but the owner, Lord Cromwell, chose to use brick. About 700,000 bricks were used to build the castle, which has been described as the finest piece of medieval brick-work in England.he castle builders of Western Europe were aware of and influenced by Roman design; late Roman coastal forts on the English  Saxon Shore  were reused and in Spain the wall around the city of Ãvila Ã¡vila Imitated roman architecture when it was built in. 1091