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Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation.
Initial thoughts around causation of eosinophilic esophagitis included damage of the esophagus caused by GERD or acidic reflux from the stomach into the esophagus. The acid would damage the lining of the esophagus and allow eosinophils to invade. It wasnât until the mid-1990s when this method started to be discredited.