cerebral cortex. The outer layer of gray matter that covers the cerebral hemispheres in the brain of many vertebrate animals and is composed of folds of nerve cells and fibers.erebral cortex. The outer layer of gray matter that covers the cerebral hemispheres in the brain of many vertebrate animals and is composed of folds of nerve cells and fibers.
Dopamine blockers and depletors are used to treat conditions that arise from the over-production or increased activity of dopamine. Dopamine blockers work by binding to and blocking the action of dopamine receptors.his prevents the receptors from using the dopamine that is present in the brain or elsewhere in the body. Conversely, dopamine depletors work by preventing dopamine from being stored or released by neurons. There are numerous types of dopamine blockers and depletors.
So how does dopamine act on the indirect pathway? Dopamine is secreted by the substantia nigra and binds to D2 receptors (these are different than the D1 receptors of the direct pathway) in the striatum.This causes striatal neurons to decrease their inhibitory message to the external segment of the globus pallidus.his is different from the direct pathway where the striatum sends a signal to the internal segment of the globus pallidus. The external segment of the globus pallidus normally indirectly (more on this in the next few paragraphs) inhibits its internal counterpart.