When used above the medical dose range, stimulants are associated with the development of stimulant psychosis. As with all addictive drugs, the overexpression of ÎFosB in D1-type medium spiny neurons in the nucleus accumbens is implicated in methylphenidate addiction.
Definitions (2) 1. The degree to which an investor or business is utilizing borrowed money. Companies that are highly leveraged may be at risk of bankruptcy if they are unable to make payments on their debt; they may also be unable to find new lenders in the future.
Grasp. 1  A gripe or seizure of the hand; a seizure by embrace, or infolding in the arms. ``The grasps of love.''. --Shak. 2  Reach of the arms; hence, the power of seizing and holding; as, it was beyond his grasp. 3  Forcible possession; hold. The whole space that's in the tyrant's grasp. --Shak.