When used above the medical dose range, stimulants are associated with the development of stimulant psychosis. As with all addictive drugs, the overexpression of ÎFosB in D1-type medium spiny neurons in the nucleus accumbens is implicated in methylphenidate addiction.
Definitions (2) 1. The degree to which an investor or business is utilizing borrowed money. Companies that are highly leveraged may be at risk of bankruptcy if they are unable to make payments on their debt; they may also be unable to find new lenders in the future.
Verb. 1. manipulate-influence or control shrewdly or deviously; He manipulated public opinion in his favor. pull strings, pull wires. act upon, influence, work-have and exert influence or effect; The artist's work influenced the young painter; She worked on her friends to support the political candidate.