The carrier frequency and incidence of alpha thalassemia vary by the type and population. Carrier frequency of this condition is reported to be the highest in individuals of Southeast Asian, African, West Indian, and Mediterranean descent.
Clitheroe Castle Museum is adjacent to the castle. The castle was listed as a Scheduled Monument on 10 April 1915 (and later, under the Ancient Monuments and Archaeological Areas Act 1979 law).It was Grade I listed on 19 May 1950.t has been suggested that Clitheroe Castle may have been first built before 1086 as there is reference to the  castellatu Rogerii pictaviensis  in the Domesday Book entry for nearby Barnoldswick. However, it is likely the passage refers to another castle.
Dover Castle is a medieval castle in the town of the same name in the English county of Kent.It was founded in the 12th century and has been described as the Key to England due to its defensive significance throughout history. It is the largest castle in England.he castle today Edit. Dover Castle is a Scheduled Monument, which means it is a nationally important historic building and archaeological site that has been given protection against unauthorised change. It is also a Grade I listed building, and recognised as an internationally important structure.