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/imÂ·muÂ·noÂ·comÂ·proÂ·mised/ (-komÂ´pro-mÄ«zd) having the immune response attenuated by administration of immunosuppressive drugs, by irradiation, by malnutrition, or by certain disease processes (e.g., cancer).
HIV is unique in its ability to compromise the immune system. Learn how the disease progresses and makes patients susceptible to serious complications. Human immunodeficiency virus (HIV) infects the cells of the immune system.In particular, HIV attacks and destroys the T helper lymphocytes, or T-cells, which are crucial to the immune system and immune response.nce a personâs viral load (a measurement of how many cells in your blood are infected with HIV) begins rising to higher and higher levels, this is an indication that the immune system is deteriorating; the disease is reaching a more advanced stage.