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Similar to heroin, oxycodone produces â along with pain management â a euphoric high caused by stimulation of the reward center of the brain. Oxycodone elevates levels of the neurotransmitter dopamine, which is considered the pleasure chemical of the brain. On the street, OxyContin is known as âOxy,â âOC,â âOxyCotton,â âHillbilly Heroin,â and âKickers,â and is often used if heroin or morphine is not available.
OxyContin Side Effects in the Kidneys. Oxycodone and the drugâs corresponding metabolites are eliminated by the kidneys following metabolism inside the liver. Although oxycodone can place increased filtration burden on the kidney, the drug does not appear to cause any direct toxic effects on the kidneys.