Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules .
Some of the most common risk factors for heart failure include: 1  Age. 2  Hypertension. 3  Physical inactivity. 4  Diabetes. 5  Obesity. 6  Smoking. 7  Metabolic syndrome. 8  Family history of heart failure. 9  Enlargement of the left ventricle.
The amount of blood is reduced to the heart causing fluid to accumulate, usually in the veins in the neck, abdomen, liver, legs, feet, and ankles. Left-sided heart failure occurs when the heart is unable to pump enough blood throughout the body. This can result in fatigue and difficulty breathing. This life-threatening condition may lead to sudden death if left untreated. The following are possible causes of death in congestive heart failure: slide 2 of 5.