Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules .
Some of the most common risk factors for heart failure include: 1  Age. 2  Hypertension. 3  Physical inactivity. 4  Diabetes. 5  Obesity. 6  Smoking. 7  Metabolic syndrome. 8  Family history of heart failure. 9  Enlargement of the left ventricle.
Learn more about what you can do to reduce your risk for heart failure by making lifestyle changes that last. Conditions that may lead to heart failure. If you have heart failure, chances are you have (or had) one or more of the conditions listed below. Some of these can be present without you knowing it. Typically these conditions cause the wear and tear that leads to heart failure. Having more than one of these factors dramatically increases your risk. View an animation of heart failure.