Diarrhea is a very common problem in children. Diarrhea is frequent, loose, or watery bowel movements (BMs) that differ from a childâs normal pattern. Sometimes diarrhea contains blood or mucus. Identifying mild diarrhea may be difficult because in healthy children, the number and consistency of BMs vary with age and diet.
Aspirin and nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs) inhibit platelet cyclooxygenase, thereby blocking the formation of thromboxane A2. These drugs produce a systemic bleeding tendency by impairing thromboxane-dependent platelet aggregation and consequently prolonging the bleeding time.
1 For CYP3A inhibitors, only those that increase AUC of CYP3A substrates by 5-fold or higher are listed. 2  Inducers listed are those that decrease plasma AUC values of substrates for that CYP enzyme by 30% or higher. Inhibitors listed are those that increase plasma AUC values of substrates for that CYP enzyme by 2-fold or higher. 2  For CYP3A inhibitors, only those that increase AUC of CYP3A substrates by 5-fold or higher are listed.