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Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation.
Although no one really knows what causes HSP, doctors do know that it occurs when the body's immune system doesn't function as it should. A protein called immunoglobulin A (IgA) is a type of antibody that works to fight infections. In HSP, IgA also gets placed in the blood vessels and causes swelling and bleeding. It is unclear why this immune reaction occurs. It often happens after a bacterial or viral infection of the upper respiratory tract (sinuses, throat, or lungs). It is seen more often in fall, winter, and spring.