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Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation.
Inside the seroma cavity is a serous fluid accumulation that originates from blood vessel injury. Over time, fibrin clots form around the fluid and result in a cavity. Fibrin clots develop because the blood contains large amounts of clotting factors and platelets responsible for clot formation.