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(However, for many people, eating lysine-rich foods may provide enough lysine that supplements may not be needed.) The typical dosages used range from a low of 500 mg (0.5 g) daily to 1,000 mg (1 g) three times daily. Some experts have even suggested dose as high as 3,000 mg (3 g) three times daily for severe outbreaks.
Safety Issues. Although lysine is an essential part of the diet, the safety of concentrated lysine supplements has not been well studied. In animal studies, high dosages have caused gallstones and elevated cholesterol levels, 15,16 so you may want to use caution when using lysine if you have either of these problems.