Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules .
Some of the most common risk factors for heart failure include: 1  Age. 2  Hypertension. 3  Physical inactivity. 4  Diabetes. 5  Obesity. 6  Smoking. 7  Metabolic syndrome. 8  Family history of heart failure. 9  Enlargement of the left ventricle.
Anything that weakens the heart's ability to fill with blood or pump blood can lead to heart failure. The three most common causes are diseased arteries in the heart (coronary artery disease, or CAD), high blood pressure, and dilated cardiomyopathy (diseased or enlarged heart muscle). Nearly any form of heart disease can lead to heart failure. Other causes include the following: