Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules .
Some of the most common risk factors for heart failure include: 1  Age. 2  Hypertension. 3  Physical inactivity. 4  Diabetes. 5  Obesity. 6  Smoking. 7  Metabolic syndrome. 8  Family history of heart failure. 9  Enlargement of the left ventricle.
Understanding Your Risk for Heart Disease Risk factors are conditions that increase your risk of developing a disease. Risk factors are either modifiable, meaning you can take measures to change them, or non-modifiable, which means they cannot be changed. Risk factors for heart disease are discussed below. You may also wish to calculate your risk of developing heart disease with our risk assessment tool. Non-modifiable Risk Factors Age