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Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation.
Any disruption of the protein may lead to atherosclerosis by causing growth of smooth muscle cells beneath the arterial wall, Keating notes. Such disruptions could be caused by the stress of high blood pressure or the buildup of cholesterol-rich plaques, which cause inflammation within blood vessels.