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Serious Causes. Severe or persistent bloating can be the result of serious medical conditions in women. For example, ovarian cysts or a uterine fibroid can be the root cause. A uterine fibroid is a tumor in the muscle of the uterus. Although uncomfortable, it is usually benign and requires no treatment. Irritable Bowel Syndrome is another cause of severe bloating, among other things. Although IBS affects both sexes, it is more common in women. Women's Health Zone reports that as many as 75 percent of IBS patients are female.
A Honor Society of Nursing (STTI) answered. There are some medications that can cause bloating. Bloating is an enlarged abdomen caused by excess gas. A few medications contain sugars that some people cannot completely digest, which can cause excess gas and bloating. Other medications include ingredients that stop the enzymes in your body from digesting your food. Talk to your doctor about switching medications if you are taking any that are causing bloating.