Cramping or pain in a leg caused by poor blood circulation. This condition is frequently caused by hardening of the arteries (atherosclerosis). Intermittent claudication occurs only at certain times, usually after exercise, and is relieved by rest.
RESULTS: 22% (29/129) of respondents admitted to abusing gabapentinoids, and of these, 38% (11/29) abused gabapentinoids in order to potentiate the 'high' they obtained from methadone. CONCLUSIONS: Gabapentinoid abuse along with methadone has not previously been described.
Sertraline does not mix well with drugs. 1  Methadone can make drowsiness worse with sertraline. 2  Taking methadone and sertraline together could make you more likely to get serotonin syndrome. 3  Tell the doctor everything that you have taken. Medicines like sertraline are called selective serotonin reuptake inhibitors (SSRIs) because they make the brain think there is more serotonin around than there actually is. 2  This means that the amount of serotonin becomes more normal and the depression becomes better.