The carrier frequency and incidence of alpha thalassemia vary by the type and population. Carrier frequency of this condition is reported to be the highest in individuals of Southeast Asian, African, West Indian, and Mediterranean descent.
Clitheroe Castle Museum is adjacent to the castle. The castle was listed as a Scheduled Monument on 10 April 1915 (and later, under the Ancient Monuments and Archaeological Areas Act 1979 law).It was Grade I listed on 19 May 1950.t has been suggested that Clitheroe Castle may have been first built before 1086 as there is reference to the  castellatu Rogerii pictaviensis  in the Domesday Book entry for nearby Barnoldswick. However, it is likely the passage refers to another castle.
The Castle was first built, entirely out of clay. It collapsed to the ground and the clay was then used as the flooring for many of the ground-floor rooms. Dover Castle is a medieval castle in Dover, Kent.It was founded in the 11th century and has been described as the Key to England due to its defensive significance throughout history.n 1088, eight knights were appointed under tenures to guard Dover Castle, their names were: William d'Albrincis; Fulberl de Dover, William d'Arsic; Geoffrey Peverell; William Maminot; Robert du Port; Hugh Crevecoeur; and Adam Fitzwilliam.