Page 1 of 8. Connotation and Denotation. Connotation and Denotation. Connotation and Denotation are two principal methods of describing the meanings of. words. Connotation refers to the wide array of positive and negative associations that. most words naturally carry with them, whereas denotation is the precise, literal definition. of a word that might be found in a dictionary.
Medical Definition of orphan drug. : a drug that is not developed or marketed because its extremely limited use (as in the treatment of a rare disease) makes it unprofitable.
Information on applications for orphan drug status can be found in the Applications for orphan drug designation. The quality, efficacy and safety of orphan drugs are assessed at the same standard as for other registered medicines.Drugs designated as orphan drugs by the TGA are shown in the table below.esignated orphan drugs are eligible for a waiver of their application and evaluation fees, but only if designation is received prior to submitting an application to register an orphan drug on the Australian Register of Therapeutic Goods (ARTG) .