Chronic granulomatous disease (CGD) is a rare (â¼1:250,000 births) disease caused by mutations in any one of the five components of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. This enzyme generates superoxide and is essential for intracellular killing of pathogens by phagocytes.
Vehicles for human transport that have two wheels and require balancing by the rider date back to the early 19th century. The first means of transport making use of two wheels arranged consecutively, and thus the archetype of the bicycle, was the German draisine dating back to 1817. The term bicycle was coined in France in the 1860s.
The oldest documented person to have ever lived was Jeanne Calment of France (February 21, 1875 - August 4th 1997), who lived to the age of 122 years and 164 days. There are â¦ many claims of people who lived to a greater age, but given their birth years, few were able to document their ages.