Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
Definition of manage for English Language Learners. : 1  to have control of (something, such as a business, department, sports team, etc.) : 2  to take care of and make decisions about (someone's time, money, etc.) : 3  to direct the professional career of (someone, such as an entertainer or athlete)