A wholesaler can act as a middleman, brokering deals between these businesses. The sale and distribution of goods to users other than end consumers. Wholesaling involves selling merchandise to retailers, wholesalers and merchants, or to industrial, commercial and institutional users. A wholesaler can act as a middleman, brokering deals between these businesses.
Hemoglobin, which carries iron, gives red blood cells their color. Iron, a mineral you ingest in food, plays a vital role in transporting oxygen to tissues throughout your body. Although iron has other functions as well, acting as an oxygen delivery system is its best-known function.
Iron deficiency leads to anemia, a decrease in the oxygen carrying capacity of blood. However, too much iron in the body can be extremely toxic to tissues because it promotes the formation of free radicals. The majority of the body's iron is found in hemoglobin of developing and mature red blood cells.Of the remaining iron, a significant portion is stored in the liver, both in the hepatocytes, and in the Kupffer cells (also known as reticuloendothelial cells), a type of macrophage found in the liver. second signal depends upon the amount of iron in body stores. Iron absorption is stimulated if the level in body stores is low. These signals (and others) regulate iron absorption in the proximal duodenum, where iron is absorbed. An important player in this regulation is the recently discovered hormone hepcidin.