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Sulfamethoxazole is eliminated renally, meaning via the kidneys and subsequently urine. The half life of sulfamethoxazole is 10 hours, which means that it is eliminated in 10 hours and thus stays in your system for 10 hours. Trace amounts will always be present for longer, but not enough to execute any therapeutic effect. Source(s): http://www.rxlist.com/cgi/generic/gantan...
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