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Definition. In Dr. Aaron Moses: pathology, a granuloma is an organized collection of macrophages. In medical practice, doctors occasionally use the term granuloma loosely to mean a small nodule. Since a small nodule can represent anything from a harmless nevus to a malignant tumor, this usage of the term is not very specific.
Note the presence of giant cells. The granulomatous lesions in this disorder are typically non-caseating. This is in constrast to TB granuloma which causes casating granuloma (slides with TB granuloma is uncommon in MRCOphth). A TB granuloma showing central necrosis (caseating granuloma) and the presence of giant cells.n addition, the macrophages may fuse together to form multinucleate giant cells (different types of inciting materials may produce different giant cells). Granulomatous lesion typically occurs when the usual acute inflammatory reaction involving neutrophils could not remove the inciting agent.