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Sulfamethoxazole is eliminated renally, meaning via the kidneys and subsequently urine. The half life of sulfamethoxazole is 10 hours, which means that it is eliminated in 10 hours and thus stays in your system for 10 hours. Trace amounts will always be present for longer, but not enough to execute any therapeutic effect. Source(s): http://www.rxlist.com/cgi/generic/gantan...
You should not use this medication if you are allergic to sulfamethoxazole or trimethoprim, or if you have: 1  severe liver or kidney disease; 2  anemia (low red blood cells) caused by folic acid deficiency; or.3  a history of low blood platelets caused by taking trimethoprim or any sulfa drug.o make sure sulfamethoxazole and trimethoprim is safe for you, tell your doctor if you have: 1  kidney or liver disease; 2  a folic acid deficiency; 3  asthma or severe allergies; 4  a thyroid disorder; 5  HIV or AIDS; 6  porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);