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Uses. Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain).
Fluoxetine is a prescription medicine used to treat depression, obsessive compulsive disorder (OCD), bulimia, and panic disorder. Fluoxetine is also used to treat Premenstrual Dysphoric Disorder (PMDD). Fluoxetine belongs to a group of drugs called selective serotonin reuptake inhibitor (SSRI). It works by changing the levels of certain chemicals in the brain that affect your mood. Fluoxetine is available in capsule, tablet, and a liquid forms.