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A real good size is a brisket from 6 to 10 pounds. The size, big or small, will be. more of a personal choice. Just remember that slow cooking your brisket for 1-. 1/2 to 2 hours per pound at 225F is a pretty fair timetable.
Bake the Brisket. 1  Place a fat-trimmed 3- to 3-1/2-pound fresh beef brisket in a 13x9x2-inch baking pan. Pour the cooking liquid over the meat. 2  Cover the pan with foil. 3  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time.