Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
Full Definition of MANAGE. transitive verb. 1. : to handle or direct with a degree of skill: as. 2. 3. 4. intransitive verb. 1. a: to direct or carry on business or affairs; also: to direct a baseball team b: to admit of being carried on.ull Definition of MANAGE. transitive verb. 1. : to handle or direct with a degree of skill: as. 2. 3. 4. intransitive verb. 1. a: to direct or carry on business or affairs; also: to direct a baseball team b: to admit of being carried on.