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No dog received an individual dose of trazodone > 300 mg. The maximum daily dose was 600 mg, which represented a combined twice-daily and asneeded dose in a dog that weighed 36 kg (79.2 lb). For as-needed doses, most clients observed that behavioral effects occurred within 1 to 2 hours of trazodone administration.
Dosage Edit. Treatment should be started with low initial doses of 25 to 50 mg daily in divided doses or in an evening single dose. The dose may be increased slowly to a maximum of 300 mg daily in ambulatory patients and to 600 mg daily in hospitalized patients.eriatric and emaciated patients should begin with 25 mg daily; this dose may be slowly increased to 300 mg. The duration of treatment should be at least one month. A 50 mg dose is recommended when using Trazodone as a sleep aid.