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(Unipolar is the term used to differentiate the difference between major depression and bipolar.) For example, people with bipolar disorder canât take anti depressants alone as a treatment for the illness due to the danger of mania caused by the anti depressants.
While antidepressants are effective treatment for people with major depressive (unipolar) disorder, antidepressants they are not always as effective for bipolar depression, and generally should not be given alone (monotherapy) in people with bipolar I disorder.ccording to the American Psychiatric Association (APA), lithium, lamotrigine, valproate, carbamazepine, and most atypical antipsychotic medications are approved by the FDA for treating one (or more) phases of bipolar disorder.