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Cook the brisket, well covered with foil, until it's tender enough that you can easily slide the tines of a fork into the meat and twist off a mouthful. Depending on the size and thickness of your piece of brisket, that might take as little as 3 to 4 hours, or as long as 8 hours.
How long per pound to cook a brisket in the oven? At 275-300 degrees preferably. Also any tips on how to prepare would be helpful also please. I asked my grandmother how to make it, she actually makes brisket quite often, yet she could not tell me how she makes it. Quite hilarious, but not quite helpful. Anyhow, thanks for your input.