Chronic granulomatous disease (CGD) is a rare (â¼1:250,000 births) disease caused by mutations in any one of the five components of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. This enzyme generates superoxide and is essential for intracellular killing of pathogens by phagocytes.
Vehicles for human transport that have two wheels and require balancing by the rider date back to the early 19th century. The first means of transport making use of two wheels arranged consecutively, and thus the archetype of the bicycle, was the German draisine dating back to 1817. The term bicycle was coined in France in the 1860s.
Let's have a look at the other pet species. The oldest rabbit on record was a wild rabbit named Flopsy, who was caught on August 6, 1964, and died 18 years and 10 months later in Tasmania, Australia. The oldest ferret on record was about 15 years old. Some people say it was 14 years old. Today, some ferret owners claim their pet is 14 years old. This means that, even though a ferret's average longevity is 7 to 9 years, longer life spans are not so rare.