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No dog received an individual dose of trazodone > 300 mg. The maximum daily dose was 600 mg, which represented a combined twice-daily and asneeded dose in a dog that weighed 36 kg (79.2 lb). For as-needed doses, most clients observed that behavioral effects occurred within 1 to 2 hours of trazodone administration.
6. 1  evaluated the effectiveness of an oral PPA formulation in 10. spayed female dogs with incontinence due to urethral sphincter mechanism. incompetence. The dogs were all initially administered PPA at a dose of 1 mg/kg. three times a day for four weeks. After this initial period, all dogs were dosed at. 2 mg/kg once daily with a sustained release formulation and monitored for 1 to 3. years. The sustained release formulation contained PPA and an anti-histamine.