Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
Definition of operation for English Language Learners. : 1  a process in which a doctor cuts into someone's body in order to repair or remove a damaged or diseased part. : 2  a usually small business or organization. : 3  an activity of a business or organization.