Page 1 of 8. Connotation and Denotation. Connotation and Denotation. Connotation and Denotation are two principal methods of describing the meanings of. words. Connotation refers to the wide array of positive and negative associations that. most words naturally carry with them, whereas denotation is the precise, literal definition. of a word that might be found in a dictionary.
Medical Definition of orphan drug. : a drug that is not developed or marketed because its extremely limited use (as in the treatment of a rare disease) makes it unprofitable.
Designation as an Orphan Drug does not alter the standard FDA regulatory requirements for drug safety and efficacy that must be established through adequate and well-controlled clinical studies, nor does it mean that the drug is safe and effective or legal to manufacture and market in the United States.esignation as an Orphan Drug does not alter the standard FDA regulatory requirements for drug safety and efficacy that must be established through adequate and well-controlled clinical studies, nor does it mean that the drug is safe and effective or legal to manufacture and market in the United States.