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Sulfamethoxazole is eliminated renally, meaning via the kidneys and subsequently urine. The half life of sulfamethoxazole is 10 hours, which means that it is eliminated in 10 hours and thus stays in your system for 10 hours. Trace amounts will always be present for longer, but not enough to execute any therapeutic effect. Source(s): http://www.rxlist.com/cgi/generic/gantan...
It has a half-life of 24 to 42 hours (based on the buprenorphine content), meaning that it takes 24 to 42 hours for the level of buprenorphine to drop by 50 percent in your blood. This means it may take several days, or even a week or longer, to be mostly out of your system.