Chronic granulomatous disease (CGD) is a rare (â¼1:250,000 births) disease caused by mutations in any one of the five components of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. This enzyme generates superoxide and is essential for intracellular killing of pathogens by phagocytes.
Vehicles for human transport that have two wheels and require balancing by the rider date back to the early 19th century. The first means of transport making use of two wheels arranged consecutively, and thus the archetype of the bicycle, was the German draisine dating back to 1817. The term bicycle was coined in France in the 1860s.
First round of the 2005 European BMX Championships held in Sainte Maxime, France on 23 April 2005. BMX, an abbreviation for bicycle motocross, is a cycle sport performed on BMX bikes, either in competitive BMX racing or freestyle BMX, or else in general on-or off-road recreation.MX began in the early 1970s when children began racing their bicycles on dirt tracks in southern California, inspired by the motocross stars of the time.