The U.S. infant mortality rate generally declined throughout the 20th century, from 100 infant deaths per 1,000 live births in 1900 to 6.89 infant deaths per 1,000 live births in 2000.
hemoglobinopathies are genetic inherited disorders of hemoglobin the oxygen carrying protein of the red blood cells the hemoglobin molecule is composed of four separate polypeptide chains of amino acids two alpha chains and two beta chains as well as four iron bearing heme groups that bind oxygenemoglobinopathies are genetic inherited disorders of hemoglobin the oxygen carrying protein of the red blood cells the hemoglobin molecule is composed of four separate polypeptide chains of amino acids two alpha chains and two beta chains as well as four iron bearing heme groups that bind oxygen
These genetic diseases include mtDNA depletion syndromes such as Alpers or early infantile hepatocerebral syndromes, and mtDNA deletion disorders, such as progressive external ophthalmoplegia (PEO), ataxia-neuropathy, or mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).his review focuses on our current knowledge of genetic defects of mtDNA replication (POLG, POLG2, C10orf2) and nucleotide metabolism (TYMP, TK2, DGOUK, and RRM2B) that cause instability of mtDNA and mitochondrial disease. PMCID: PMC3244805. [PubMed-indexed for MEDLINE].