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Then, the treatment will be more difficult as well. These are the most common causes of a bump on the roof of mouth: 1  Enlarged or irritated incisive papilla. This can also be caused by excessive tobacco chewing.  Smoking â people who smoke either a cigar or a pipe present an increased risk for mouth roof bumps.
Even a tooth abscess can not only cause an ulcer but the infection can spread to the palate and lead to a sore on roof of mouth. 5. This is a condition that is characterized by the sensation of a dry mouth. In most patients roof of the mouth hurts but the cause of the disease is unknown.