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Ankylosing Spondylitis (AS) is a type of progressive arthritis that leads to chronic inflammation of the spine and sacroiliac joints. It can also affect other joints and organs in the body, such as the eyes, lungs, kidneys, shoulders, knees, hips, heart, and ankles.
The symptoms of ankylosing spondylitis are caused by inflammation of parts of the lower spine. This inflammation can lead to damage and fusion-through the growth of new bone-in the spine, hips, and the joints between the two (the sacroiliac joints). An inflammatory disease, ankylosing spondylitis is characterized by pain and stiffness and can lead to loss of mobility. 2  The disease process leads to erosion of bones in the spine, which can become fused, leading to spinal deformity in the advanced cases.