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What Is Osteonecrosis? Osteonecrosis is a condition that develops as a consequence of temporary or permanent loss of blood supply to bone. The lack of blood supply to bone causes that part of the bone to die. The bone may collapse as it dies, and if the affected bone is near a joint, the joint surface can collapse. Osteonecrosis can affect any bone but most commonly affects the ends of the femur, upper arm bone, knees, shoulders, and ankles.
Osteonecrosis of the jaw is a severe bone disease that affects the jaws. Various forms of ONJ have been described over the last 160 years, and a number of causes have been suggested in the literature. Osteonecrosis of the jaw associated with bisphosphonate therapy, which is required by some cancer treatment regimens, has been identified and defined as a pathological entity since 2003. The possible risk from lower oral doses of bisphosphonates, taken by patients to prevent or treat osteoporosis,