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The innervation is supplied by the inferior gluteal nerve, a branch of the sacral plexus (L4-S2). Numerous vessels and nerves run under the gluteus maximus muscle, including the sciatic nerve, the pudendal nerve and the superior gluteal vessels.
The arteries that supply the posterior compartment of the thigh arise from the inferior gluteal and the perforating branches of the profunda femoris artery, a major collateral branch of the femoral artery and part of the anterior compartment of thigh.