Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.Ulloque RA, Chweh AY, Swinyard EA.The effects of gamma-aminobutyric acid (GABA) receptor agonists [4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol THIP]; [progabide and baclofen] on the minimal neurotoxicity and anticonvulsant activity of pentobarbital and phenobarbital in mice were investigated.n contrast, baclofen at toxic doses potentiated the anti-PTZ activity of pentobarbital and phenobarbital. Combinations of progabide and pentobarbital or progabide and phenobarbital interacted additively by the maximal electroshock seizure (MES) test.
Recorded in the spellings of Mac, Mack, and Make, not surprisingly this ancient surname is Scottish, but possibly of English origins. It is believed to derive from theYorkshire surname Macwra, itself claimed to be a development of the Danish-Viking personal name Makr.hat is certain is that the name has been held for many centuries by a Berwickshire family, and early examples of the name recording include John Mak, who witnessed a land charter in Ayton, in the year 1470, and William Make, recorded in Lanark in 1510.
Origin of the name Jacob: From the Ecclesiastic Late Latin Iacobus, which is from the Greek IakÅbos, a name derived from the Hebrew Yaakov. The name has its root in ya`aqob (seizing by the heel, supplanting).The name is borne in the Bible by the father of twelve sons who became the progenitors of the twelve tribes of Israel.Pet: Jake.rom the Ecclesiastic Late Latin Iacobus, which is from the Greek IakÅbos, a name derived from the Hebrew Yaakov. The name has its root in ya`aqob (seizing by the heel, supplanting).