Page 1 of 8. Connotation and Denotation. Connotation and Denotation. Connotation and Denotation are two principal methods of describing the meanings of. words. Connotation refers to the wide array of positive and negative associations that. most words naturally carry with them, whereas denotation is the precise, literal definition. of a word that might be found in a dictionary.
Medical Definition of orphan drug. : a drug that is not developed or marketed because its extremely limited use (as in the treatment of a rare disease) makes it unprofitable.
1 Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.  PubMed is a searchable database of medical literature and lists journal articles that discuss Malignant peripheral nerve sheath tumor.