Chronic granulomatous disease (CGD) is a rare (â¼1:250,000 births) disease caused by mutations in any one of the five components of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. This enzyme generates superoxide and is essential for intracellular killing of pathogens by phagocytes.
Vehicles for human transport that have two wheels and require balancing by the rider date back to the early 19th century. The first means of transport making use of two wheels arranged consecutively, and thus the archetype of the bicycle, was the German draisine dating back to 1817. The term bicycle was coined in France in the 1860s.
Welcome to County Cycles! When we opened the doors in 1981, we hoped to sell a few bikes and have some fun. We never dreamed that we'd be here more than 35 years later! Technology may have changed the bikes we sell, but our service has stood the test of time. We're still the same friendly, helpful people we set out to be way back when. We're proud to be among the best Felt. Giant and Liv bicycle dealers in the United States.