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Sulfamethoxazole is eliminated renally, meaning via the kidneys and subsequently urine. The half life of sulfamethoxazole is 10 hours, which means that it is eliminated in 10 hours and thus stays in your system for 10 hours. Trace amounts will always be present for longer, but not enough to execute any therapeutic effect. Source(s): http://www.rxlist.com/cgi/generic/gantan...
1 Most antibiotics leave your body in about 72 hours since the last administration....  2 Antiboitics take 2-3 weeks to leave youe system on average,they simply clean up the....  3 Different antibiotics last for different period of time....  4 So it will stay in your body for 2 1/2 days.... The half life of Bactrim is 12 hrs, so it will stay in your body for 2 1/2 days. But, once the allergic rash has started, the rash will sustain itself for 14 days. You`re on the appropriate treatment.. just make sure you drink a lot to flush the medicine out.