Page 1 of 8. Connotation and Denotation. Connotation and Denotation. Connotation and Denotation are two principal methods of describing the meanings of. words. Connotation refers to the wide array of positive and negative associations that. most words naturally carry with them, whereas denotation is the precise, literal definition. of a word that might be found in a dictionary.
Medical Definition of orphan drug. : a drug that is not developed or marketed because its extremely limited use (as in the treatment of a rare disease) makes it unprofitable.
Rebif overturned Avonexâs orphan drug exclusivity (7 MAR 2002) EU: 10 Years of marketing exclusivity from approval Reduced R&D Costs Methodology on Classifying an Orphan Drug We have identified all products that have orphan drug designations filed in the US, EU or Japan.rior to the 1983 Act, 38 orphan drugs were approved. To date, 468 indication designations covering 373 drugs have been approved.The success of the original Orphan Drug Act in the US led to it being adopted in other key markets, most notably in Japan in 1993 and in the European Union in 2000.