Page 1 of 8. Connotation and Denotation. Connotation and Denotation. Connotation and Denotation are two principal methods of describing the meanings of. words. Connotation refers to the wide array of positive and negative associations that. most words naturally carry with them, whereas denotation is the precise, literal definition. of a word that might be found in a dictionary.
Medical Definition of orphan drug. : a drug that is not developed or marketed because its extremely limited use (as in the treatment of a rare disease) makes it unprofitable.
ORPHANET is a database dedicated to information on rare diseases and orphan drugs (available in, , , , and). National Library of Medicine's web site for consumer information about genetic conditions and the genes or chromosomes responsible for those conditions. (browse: - -).