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Elephantiasis is a syndrome caused by infection with a nematode parasite called the filarial worm. The parasite is transmitted form human to human via the female mosquito and grows into an adult worm that lives in the lymphatic system of a human.
This blockage causes fluids to collect in the tissues, which can lead to great swelling, called lymphedema.. Limbs can swell so enormously that they resemble an elephant's foreleg in size, texture, and color. This is the severely disfiguring and disabling condition of elephantiasis.