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Hepatitis B vaccine is a vaccine for the prevention of hepatitis B, an infection caused by the hepatitis B virus (HBV) .The vaccine contains one of the viral envelope proteins, hepatitis B surface antigen (HBsAg). It is produced by yeast cells, into which the genetic code for HBsAg has been inserted.he vaccine contains one of the viral envelope proteins, hepatitis B surface antigen (HBsAg).
HEPATITIS B VACCINATION. The first hepatitis B vaccine became commercially available in the United States in 1982. In. 1986, a hepatitis B vaccine produced by recombinant DNA technology was licensed and a. second recombinant-type hepatitis B vaccine was licensed in 1989. The two recombinant DNA. vaccines (Recombivax HB and Engerix-B) are the only hepatitis B vaccine preparations. currently used in the United States.