Eat a well- balanced diet with plenty of fiber. Good sources of fiber are fruits, vegetables, legumes, and whole-grain bread and cereal (especially bran). Drink 1 1/2 to 2 quarts of water and other fluids a day (unless your doctor has you on a fluid-restricted diet). Fiber and water work together to keep you regular.
Zofran: FDA Pregnancy Category B. According to the United States Food and Drug Administration (FDA), ondansetron (Zofran) is a Pregnancy Category B drug. This means there is no evidence of risk in humans. Either animal findings show risk, but human findings do not; or, if no adequate human studies have been done, animal findings are negative.
FDA Warns Against Zofran Use in Pregnancy. The FDA has issued an updated warning against Ondansetran, better known by its brand name, Zofran, use in pregnancy discussed in OBGYN News. Zofran is a 5-HT3 receptor antagonist approved by the FDA for preventing nausea and vomiting related to cancer chemotherapy and surgery. It has been used off-label to treat nausea and vomiting in pregnancy. Based on recent studies regarding the association between Zofran use in early pregnancy and congenital cardiac malformations and oral clefts (cleft lip and palate), the FDA has cautioned against its use in pregnancy.