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No dog received an individual dose of trazodone > 300 mg. The maximum daily dose was 600 mg, which represented a combined twice-daily and asneeded dose in a dog that weighed 36 kg (79.2 lb). For as-needed doses, most clients observed that behavioral effects occurred within 1 to 2 hours of trazodone administration.
In the other case, it was reported that acute dystonia observed 2 weeks after the dose of trazodone had been increased to 50 mg/day (7). There was also no case of tardive dyskinesia reported with trazodone (5). Trazodone has generally antagonistic effect on serotonergic receptors in particular 5-HT1A, 5-HT1C and 5-HT2.