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Sulfamethoxazole is eliminated renally, meaning via the kidneys and subsequently urine. The half life of sulfamethoxazole is 10 hours, which means that it is eliminated in 10 hours and thus stays in your system for 10 hours. Trace amounts will always be present for longer, but not enough to execute any therapeutic effect. Source(s): http://www.rxlist.com/cgi/generic/gantan...
PRESCRIBED FOR: Sulfamethoxazole is used for the treatment of malaria (in combination with quinine sulfate and pyrimethamine), conjunctivitis (inflammation of the conjunctiva of the eye) due to chlamydia, toxoplasmosis (in combination with pyrimethamine), and urinary tract infections (UTI).ulfamethoxazole is now used primarily in combination with trimethoprim, a combination product known as Bactrim or Septra. Sulfamethoxazole was approved by the FDA in 1961. According to the FDA database, all brand and generic formulations of sulfamethoxazole have been discontinued.