Crowns may be temporary or permanent and may be made out of materials such as porcelain, resin, or metal. Dentures Dentures, removable replacements for missing teeth, come in two types: partial and complete dentures. Dental implants and bridges are suitable alternatives to dentures.
Investigational Drugs and Devices (IND/IDE) Overview. As defined by the Food and Drug Administration (FDA), an IND, or investigational new drug application, is a request for authorization from the FDA to administer an investigational drug or biological product to humans.
1 Investigational Medicinal Product (IMP) Introduction To facilitate clinical trials in the case of multi-centre trials carried out in more than one Member States it is necessary to have a common understanding of the definition of an investigational medicinal product.nother consequence of the definition of a medicinal product as an IMP is that it must be recorded in the EudraCT database, as stated in the Commission guidance on applications to the competent authority (CT-04-EN) 4. 1 OJ L 121 1.5.2001 p.34 2 Volume 10 Clinical Trials Chapter V 3 OJ L 91 9.4.2005 p. 13.