The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
The Beast: Singing With Iron Maiden The Drugs, the Groupies . . . the Whole Story [Paul Di'Anno] on Amazon.com. *FREE* shipping on qualifying offers. Paul Di'Anno's tale is one of drugs, guns, and alcohol; of extended periods banged up in prison; and of his time fronting the mighty Iron Maiden. His controversial antics off-stage are even more shocking than his existence under the spotlights.