Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
Odd number means the freeway runs north-south, while even numbered freeways travel east and west. For example, interstate 5 (I-5) goes all the way from the Southern border in San Diego to the Northern border in Blaine, WA. I-10, on the other hand, connects the West Coast of San Diego and the East Coast of Jacksonville, FL. Odd freeway numbers start from the West Coast, and increase toward east.