The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Janis Ian. Janis Ian was born on April 7, 1951 in New York City, New York, USA as Janis Eddy Fink. She has been married to Patricia Snyder since August 27, 2003. She was previously married to Tino Mendes Sargo and Eric J Sterling. See full bio Â».