The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
OXFORD PAPERBACK REFERENCE. The Concise Oxford Dictionary of. Literary Terms. Chris Baldick is Professor of English at Goldsmiths'. College, University of London. He edited The Oxford. Book of Gothic Tales (1992), and is the author of In. Frankenstein's Shadow (1987), Criticism and Literary. Theory 1890 to the Present (1996), and other works of.