The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Jan (pronounced Yann or Yaan) is a variant of John in various languages and is a short version of Johannes. The name is used in Catalan, Czech, Polish, Dutch, Scandinavian, Cornish, Devon dialect, German, Afrikaans, Northern Germanic and Western Slavic Languages. The Slovak spelling is Jan. jÃ¡n