The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Jim Butcher. Jim Butcher (born October 26, 1971) is an American author best known for his contemporary fantasy book series The Dresden Files. He is also the author of the Codex Alera series, and the Cinder Spires series. 1 Career and bibliography 1.1 Dresden Files series 1.1.1 Audiobooks and game.