The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Iron Maiden's Bruce Dickinson, who was diagnosed with throat cancer in 2014. Last month, Iron Maiden released its 16th album, The Book of Souls. Bruce Dickinson isn't through just yet.It is the end of a 12-hour press day where the Iron Maiden vocalist has been answering a multitude of questions, most concerning the iconic heavy metal band's 16 th full-length album, The Book of Souls.ron Maiden's Bruce Dickinson, who was diagnosed with throat cancer in 2014. Last month, Iron Maiden released its 16th album, The Book of Souls. Bruce Dickinson isn't through just yet.