Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
In some countries, lanes are described as being on the 'inside' or the 'outside' of a road - which one the passing lane is varies. In modern traffic planning, passing lanes on freeways are usually designed for through/express traffic, while the lanes furthest from the center of the road have entry/exit ramps.