The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Bernadette Maryann Rostenkowski-Wolowitz, (nee NÃ©e), Rostenkowski.Ph. , d is a former waitress at The Cheesecake factory and has earned Her.Ph d in microbiology and has a lucrative job at a pharmaceutical. Company she began Dating Howard wolowitz . In The Creepy Candy Coating  corollary and eventually married him . in