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Kidney failure. High blood pressure is one of the most common causes of kidney failure. That's because it can damage both the large arteries leading to your kidneys and the tiny blood vessels (glomeruli) within the kidneys. Damage to either makes it so your kidneys can't effectively filter waste from your blood.
Different blood pressure medications have different side effects. Calcium channel blockers are used to lower blood pressure, and the biggest side effect is having some edema or swelling. There are medications that may affect the kidneys. There are medications that slow the heart rate down and may make you a little bit tired or fatigued. However, without medication, the biggest side effect of hypertension is a stroke. Other negative effects of high blood pressure include heart failure, heart attack and kidney failure.