1 Report homozygous mutations in the 15-hydroxyprostaglandin dehydrogenase gene in patients with primary hypertrophic osteoarthropathy. 2  Results demonstrate that 15-PGDH acts as a tumor suppressor in gastric cancer and provide further validation for 15-PGDH as a potential therapeutic target for gastric cancer. Genetic variants in HPGD encoding 15-PGDH, appear to modulate colorectal risk. 2  The present study appears to be the first to evaluate possible associations between genetic heterogeneity in HPGD and CRC risk. 3  Observational study of gene-disease association and gene-environment interaction.
Here's a listing of the ten most popular languages spoken worldwide, along with the approximate number of primary or first language speakers for that language. 1. Mandarin Chinese - 882 million. 2. Spanish - 325 million. 3. English - 312-380 million. 4. Arabic - 206-422 million.
The second-most popular color varies more from place to place, though it's always one of three other options: green (second in Thailand, China and the United States), red (in Indonesia, Singapore, Germany and Britain), or purple (in Hong Kong). In Malaysia and Australia red and purple tied for second.