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Standing is a natural human posture and by itself poses no particular health hazard. However, working in a standing position on a regular basis can cause sore feet, swelling of the legs, varicose veins, general muscular fatigue, low back pain, stiffness in the neck and shoulders, and other health problems.
If we gain weight, NEAT tends to rise, whereas when we lose weight, NEAT often plummets, and people end up sitting more without moving as much. As NEAT researcher James Levine puts it, we may come to appreciate that spontaneous physical activity is not spontaneous at all but carefully programmed. Even standing as opposed to sitting can be beneficial, which has fueled the popularity of standing desks. Levine JA. Non-exercise activity thermogenesis (NEAT).