New Yorkâbased Bristol-Myers Squibb (BMS) acquired Flexus Biosciences in San Carlos, California, for $ 800 million upfrontâwith another $ 450 million in milestones on offerâlocking in one of the last remaining unpartnered programs targeting the indoleamine-2,3 dioxygenase (IDO) enzyme.IDO inhibition helps to reveal the target to the immune system.â. IDO is overexpressed by antigen presenting cells in many cancers. âWe know that the expression of IDO usually correlates with a significantly poor prognosis,â says Carl Decicco, head of discovery and R&D at BMS.
Some of the more common symptoms of concussion include. 1  headache, 2  feeling foggy, or that one's thinking is slowed or altered, 3  nausea, 4  lightheadedness, 5  dizziness, 6  irritability or emotional changes,  problems concentrating or remembering new information.
Specific types and symptoms of head injuries include: 1  Concussion: Also called a mild traumatic brain injury. This includes injuries to the brain that are caused by a blow to the head or body, a fall, or another trauma that jars or shakes the brain inside the skull. People who suffer from concussions may not always exhibit symptoms that are apparent to others. Symptoms of a concussion and minor head injuries include: