New Yorkâbased Bristol-Myers Squibb (BMS) acquired Flexus Biosciences in San Carlos, California, for $ 800 million upfrontâwith another $ 450 million in milestones on offerâlocking in one of the last remaining unpartnered programs targeting the indoleamine-2,3 dioxygenase (IDO) enzyme.IDO inhibition helps to reveal the target to the immune system.â. IDO is overexpressed by antigen presenting cells in many cancers. âWe know that the expression of IDO usually correlates with a significantly poor prognosis,â says Carl Decicco, head of discovery and R&D at BMS.
Some of the more common symptoms of concussion include. 1  headache, 2  feeling foggy, or that one's thinking is slowed or altered, 3  nausea, 4  lightheadedness, 5  dizziness, 6  irritability or emotional changes,  problems concentrating or remembering new information.
Right after the injury you may be dazed, lose consciousness, or have a seizure. Symptoms may occur right away, or not happen for days to weeks after your concussion. They may last anywhere from a few hours to several weeks. After the injury, you may have one or more of these symptoms: Mild to moderate headache.