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Other hormone transport proteins are relatively non-selective, transporting almost any lipophilic molecule that enters the bloodstream, including steroid and thyroid hormones, plant-derived flavonoids, retinoids (vitamin A), fatty acids, and antibiotics.hese transport proteins deliver the hormones to their target cells and protect them from being chemically altered, inactivated, and eliminated from the body by the liver and kidneys. Some hormone transport proteins in plasma are highly selective, transporting only steroid or only thyroid hormones.
The extent of drug distribution into tissues depends on the degree of plasma protein and tissue binding. In the bloodstream, drugs are transported partly in solution as free (unbound) drug and partly reversibly bound to blood components (eg, plasma proteins, blood cells).he drug penetration rate into CSF, similar to other tissue cells, is determined mainly by the extent of protein binding, degree of ionization, and lipid-water partition coefficient of the drug.