New Yorkâbased Bristol-Myers Squibb (BMS) acquired Flexus Biosciences in San Carlos, California, for $ 800 million upfrontâwith another $ 450 million in milestones on offerâlocking in one of the last remaining unpartnered programs targeting the indoleamine-2,3 dioxygenase (IDO) enzyme.IDO inhibition helps to reveal the target to the immune system.â. IDO is overexpressed by antigen presenting cells in many cancers. âWe know that the expression of IDO usually correlates with a significantly poor prognosis,â says Carl Decicco, head of discovery and R&D at BMS.
Some of the more common symptoms of concussion include. 1  headache, 2  feeling foggy, or that one's thinking is slowed or altered, 3  nausea, 4  lightheadedness, 5  dizziness, 6  irritability or emotional changes,  problems concentrating or remembering new information.
Concussion Symptoms: How Do I Know If I Have a Concussion? Most often, itâs athletes that are considered most prone to concussions, a brain injury that is either caused when the head suffers a severe blow or when the body is shaken and the brain is jostled as a result. However, we are all at risk for concussions whether we play sports regularly or not.