The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Biography by Barry Weber. At the forefront of the New Wave of British Heavy Metal, and a major metal contender from the late '70s into the 21st century. Artist Biography by Barry Weber. Known for such powerful hits as Two Minutes to Midnight and The Trooper, Iron Maiden are one of heavy metal's most influential bands. They're also one of metal's most enduring and distinctive acts, thanks to their melodic guitars, ambitious songwriting, powerhouse vocalist Bruce Dickinson, and iconic mascot Eddie.