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Venous Insufficiency. Venous insufficiency, also know as venous reflux, is the impaired return of venous blood from the legs and feet, often manifesting as varicose veins, swollen ankles, aching legs, skin changes or venous ulcers. In many cases, venous insufficiency is the result of over-dilation of the venous vessels in the legs.
Weakness or damage to veins in your legs. Chronic venous insufficiency, in which the one-way valves in your leg veins are weakened or damaged, allows blood to pool in the leg veins and cause swelling. Abrupt onset of swelling in one leg accompanied by pain in your calf can be due to a clot in one of your leg veins.