What causes wrinkled peeling fingertips? If you have fingertips peeling and wrinkling, you could be suffering from nerve insufficiency, occupational exposure or even diabetes. Peeling is one of the most common signs, usually visible on the toes and fingers.
Hypothyroidism occurs when your thyroid does not produce enough hormones, which can result in a slow metabolism marked by weight gain, fatigue and sluggishness. If you gain weight, your body will not effectively make energy from food and may contribute to a slowed metabolism.
Conversely, to slow down or halt a pathway, cells can decrease the amount of an enzyme or use inhibitors to make the enzyme inactive. Such up- and down-regulation of metabolic pathways is often a response to changes in concentrations of key metabolites in the cell. For example, a cell may take stock of its levels of intermediate metabolites and tune the glycolytic pathway and the synthesis of glucose accordingly.