The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Photo by Karen Hacker with The Portrait Gallery, located in Independence, MO. Jim Butcher is the author of the Dresden Files, the Codex Alera, and a new steampunk series, the Cinder Spires. His resume includes a laundry list of skills which were useful a couple of centuries ago, and he plays guitar quite badly. An avid gamer, he plays tabletop games in varying systems, a variety of video games on PC and console, and LARPs whenever he can make time for it.