Pathogenic mutation. p-a rare allele that exist at a frequency of less than .01 in the human population. v- a change in DNA sequence that may or may not be pathogenic. patho- change in DNA sequence that has an effect on the encoded protein of gene expression that results in disease.
In the fall of 1791, Washington learned of the newly patented automated milling system invented by Oliver Evans. Evans received U.S. Patent #3 for his groundbreaking system, which moved wheat and flour throughout the mill without the need of manual labor. Washington purchased a license for the patent and had the milling system installed in his gristmill. Today, this milling system is faithfully interpreted, fully-functioning, and open to guests on a seasonal basis.
Simon E. Monroe patented a hair straightener in 1906 that was comprised of metallic teeth that are combed through the hair, while in 1909 Issac K. Shero patented a hair straightener comprised of two flat irons that are heated and pressed together. Years later, Sharrell invented heated metal hair-care implements, such as hot combs. The hot metal straightener slid easily through the hair, causing less damage and dryness than previously-used techniques. Later, ceramic and electrical straighteners were introduced, allowing for adjustment of heat settings and straightener size.