TALKEETNA, Al. (KTUU) - A cat named Stubbs has been the mayor of Talkeetna, Alaska for nearly all of his life. It's been that way for more than a decade in the small tourist town that boasts nearly 900 residents.
DAT is an integral membrane protein that removes dopamine from the synaptic cleft and deposits it into surrounding cells, thus terminating the signal of the neurotransmitter. Dopamine underlies several aspects of cognition, including reward, and DAT facilitates regulation of that signal.
A B After a neurotransmitter molecule has been recognized by a post-synaptic receptor, it is released back into the synaptic cleft. Once in the synapse, it must be quickly removed or chemically inactivated in order to prevent constant stimulation of the post-synaptic cell and an excessive firing of action potentials.Some neurotransmitters are removed from the synaptic cleft by special transporter proteinson the pre-synaptic membrane.europeptide neurotransmitters merely quickly diffuse away from the receptors into the surrounding medium. One important neurotransmitter, acetylcholine, has a specialized enzyme for inactivation right in the synaptic cleft called acetylcholinesterase (AChE.