1 Report homozygous mutations in the 15-hydroxyprostaglandin dehydrogenase gene in patients with primary hypertrophic osteoarthropathy. 2  Results demonstrate that 15-PGDH acts as a tumor suppressor in gastric cancer and provide further validation for 15-PGDH as a potential therapeutic target for gastric cancer. Genetic variants in HPGD encoding 15-PGDH, appear to modulate colorectal risk. 2  The present study appears to be the first to evaluate possible associations between genetic heterogeneity in HPGD and CRC risk. 3  Observational study of gene-disease association and gene-environment interaction.
Here's a listing of the ten most popular languages spoken worldwide, along with the approximate number of primary or first language speakers for that language. 1. Mandarin Chinese - 882 million. 2. Spanish - 325 million. 3. English - 312-380 million. 4. Arabic - 206-422 million.
In 2011, the second-most spoken language in the United Kingdom was Scots, followed by Polish, an immigrant language. The fourth most-spoken languageâ Welsh âis an official language in Wales, the only de jure official language in any part of the UK.n 2011, the second-most spoken language in the United Kingdom was Scots, followed by Polish, an immigrant language. The fourth most-spoken languageâ Welsh âis an official language in Wales, the only de jure official language in any part of the UK.