Pathogenic mutation. p-a rare allele that exist at a frequency of less than .01 in the human population. v- a change in DNA sequence that may or may not be pathogenic. patho- change in DNA sequence that has an effect on the encoded protein of gene expression that results in disease.
In the fall of 1791, Washington learned of the newly patented automated milling system invented by Oliver Evans. Evans received U.S. Patent #3 for his groundbreaking system, which moved wheat and flour throughout the mill without the need of manual labor. Washington purchased a license for the patent and had the milling system installed in his gristmill. Today, this milling system is faithfully interpreted, fully-functioning, and open to guests on a seasonal basis.
The Water Clock Around 1400 BC (around 3,400 years ago), the Egyptians invented the water clock, or as they called it the Clepsydra (pronounced KLEP-suh-druh). These water clocks were made from two containers of water, one higher than the other.s the clocks became more accurate, so a new device was needed and so in 1577, Jost Burgi invented the minute hand. This addition had many problems and was not considered practical until the a man named Christian Huygens invented the pendulum clock.