The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Those things donât always go together. Jan was funny, supportive, inspirational, professional, and just delightful in every way. My heart is heavy to think of Jan Hooks not in the world. I watched the short film that Tom Schiller made with her and Phil Hartman, âLove is a Dream,â over and over.That both of them are gone seems impossible. wish VJ had had the self-control not to bring religion into it. While most of the tribute was nice, she couldn't resist bringing up Jan's quote about her from the book and using that as an opportunity to brand her an unbeliever (and imply that she's forever lost and burning in hell).