The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Iron Maiden were formed on Christmas Day 1975 by bassist Steve Harris shortly after he left his previous group, Smiler. Harris attributes the band's name to a film adaptation of The Man in the Iron Mask from the novel by Alexandre Dumas, the title of which reminded him of the iron maiden torture device.