The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Comedian Jan Hooks dies at age 57. (CNN) -- Jan Hooks, the actress and comedian who rose to fame with sly turns on Saturday Night Live as Ivana Trump, Tammy Faye Bakker, Sinead O'Connor and as part of the lounge-singing Sweeney Sisters, has died. She was 57. Her representative, Lisa Lieberman, confirmed the death to CNN.