prometaphase. Prometaphase is the second phase of mitosis, the process that separates the duplicated genetic material carried in the nucleus of a parent cell into two identical daughter cells. During prometaphase, the physical barrier that encloses the nucleus, called the nuclear envelope, breaks down. The breakdown of the nuclear envelope frees the sister chromatids from the nucleus, which is necessary for separating the nuclear material into two cells.
The Sistine Chapel ceiling, painted by Michelangelo between 1508 and 1512, is a cornerstone work of High Renaissance art. The ceiling is that of the Sistine Chapel, the large papal chapel built within the Vatican between 1477 and 1480 by Pope Sixtus IV, for whom the chapel is named. It was painted at the commission of Pope Julius II. The chapel is the location for papal conclaves and many other important services.
Next was the Pieta. It was started in 1498 and finished in 1500. He began Doni Tondo in 1503, taking him two years to complete the painting. In 1534, twenty-three years after the Sistine Chapel was completed, Michelangelo began to paint The Last Judgment, located over the altar at the same church as the Sistine Chapel.