The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Danko Jones. Toschie, singer of Audrey Horne, jumps on the podcast with Danko to talk about Kiss & Kiss tattoos, being a tattoo artist, Hank Von Helvete and The Garage in Bergen, Norway. The one and only Dave Hodge, legendary NHL hockey sportscaster, sat down with Danko to talk music, and only music!