Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
Currently these highways are again identified as provincial highways or provincially maintained highways by the Ontario Ministry of Transportation. The Highway Traffic Act, amended as recently as 2006, still refers to them as King's Highway.00-series highways are a special class of provincial highways, being designed to be exclusively controlled-access freeways for the entire length of the highway. At present, all of them are located in Southern Ontario, where they form a network similar to the US Interstate Highways.