Medical Definition of DISABLE. : to deprive of a mental or physical capacity. Dictionary: Definition of disable. Thesaurus: All synonyms and antonyms for disable.
While the effects of Vicodin last around 4 hours, traces of the drug can remain in your system for up to 72 hours. In some adults you can still find traces of the drug in your system after 5 days.
Report Abuse. When I have taken Vicodin...It would take about 20 minutes for it to kick-in....I know that depending on what dose you are taking and how bad your pain is can also effect how long it takes to kick-in... Chi Town Jaki Â· 8 years ago.