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You can use oregano oil in a variety of ways, depending on your health needs: 1  Topically for athlete's foot or nail fungus. 2  Inhaled to treat sinus infections or colds. 3  Under your tongue to help treat infections or parasites.
If you have full strength oregano oil, mix 1 drop of oregano oil with a single teaspoon of a mild, food-grade oil such as olive oil or coconut oil. If you need enough oil to cover a larger skin area, maintain the 1 drop oregano and 1 teaspoon other oil ratio for the entire mixture.