Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
Kings Highway- known outside the Bible as Trajans Highway, began at Ezion-geber on the Gulf of Aqaba and ran north to Amman, joined the Great Trunk Road at Damascus 3. Old Assyrian Caravan Road- used to carry Assyrian economic and military interest to Asia Minor, began at the Assyrian capital and ran west to Troy on the west coast of Asia Minor