The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Soundtrack | Composer | Actor. Isaac Brock is from Issaquah, Washington. His band, Modest Mouse, was formed in 1993 and originally included himself as guitar/vocals, Eric Judy as bass, and Jeremiah Green on drums. They practiced their music in a shed Isaac built next to his mother's trailer; it was called The Shed...