Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
In the U.S. state of Indiana, Interstate 65 traverses the state from southeast to northwest. The Indiana portion begins near Louisville, Kentucky and travels north, passing through Columbus, Indianapolis, and Lafayette. Interstate 65 terminates near Gary on the Indiana Toll Road. Interstate 65 covers 261.27 miles (420.47 km) in the state of Indiana. This is one of the principal interstate highways that cross the state, and, more specifically, intersect at the city of Indianapolis, that has given the state the nickname of  Crossroads of America .