New Yorkâbased Bristol-Myers Squibb (BMS) acquired Flexus Biosciences in San Carlos, California, for $ 800 million upfrontâwith another $ 450 million in milestones on offerâlocking in one of the last remaining unpartnered programs targeting the indoleamine-2,3 dioxygenase (IDO) enzyme.IDO inhibition helps to reveal the target to the immune system.â. IDO is overexpressed by antigen presenting cells in many cancers. âWe know that the expression of IDO usually correlates with a significantly poor prognosis,â says Carl Decicco, head of discovery and R&D at BMS.
Some of the more common symptoms of concussion include. 1  headache, 2  feeling foggy, or that one's thinking is slowed or altered, 3  nausea, 4  lightheadedness, 5  dizziness, 6  irritability or emotional changes,  problems concentrating or remembering new information.
Headaches are common in the first few days after a mild traumatic brain injury. If headaches are improving, you do not have to worry or seek urgent care. Headaches have several potential causes, and simply referring to all headaches after trauma as post traumatic headaches does not identify cause or treatment.ecause the symptoms after concussion are very similar to the symptoms that persist long after the injury, the distinction between concussion symptoms and PCS symptoms is often uncertain. The factors that extend symptoms-not just the injury severity-may need to be identified for proper treatment.