The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
This article is about the Iron Maiden singer. For the fictional music producer, see More cowbell. Paul Bruce Dickinson (born 7 August 1958), known professionally as Bruce Dickinson, is an English singer, songwriter, musician, airline pilot, author and broadcaster. He is the lead singer of the heavy metal band Iron Maiden and is renowned for his wide-ranging operatic vocal style and energetic stage presence.