Nucleus-The nucleus is the control center of the cell. It is the largest organelle in the cell and it contains the DNA of the cell. DNA (Deoxyribonucleic Acid) contains all the information for cells to live, perform their functions and reproduce.
Int J Neurosci 1993 May; 70(1-2):75-84 ABSTRACT Monoamine oxidase is an iron containing enzyme that exists as 2 isozymes, A and B, that have different affinities for various amines as substrates. The activity of monoamine oxidase helps to maintain neuron firing rates throughout the body within homeostatic limits.ther drugs that inhibit monoamine oxidase are used to treat patients with atypical depression, panic attacks or post traumatic stress syndrome. It is hypothesized that the emotions act as positive or negative reinforcers of behavior patterns that increase the probability of survival of the organism.
Perhaps importantly, monoamine oxidase B (MAO-B) is located in the mitochondrial wall and plays a significant role in dopamine degradation in PD. This can explain the symptomatic actions of MAO-B inhibitors, such as selegiline and rasagiline on motor symptoms of PD.n this brief review, the role played by mitochondria is examined and in turn, how monoamine oxidase B (MAO-B) located in the inner mitochondrial wall might be a target for modifying cell death in PD through the use of selective MAO-B inhibitors.