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Another reaction is the prompt for saliva to be produced, which allows us to easily chew and digest our food. For people with long-term CPAP use, the theory is that loss of taste and smell might actually be due to becoming desensitized from the smell of the CPAP machine. This can then cause the loss of taste.
Even if one uses a CPAP humidifier, the water chamber only holds so much and when it depletes of water during the night, nasal lining dryness can occur quickly and I can attest to the painful result. Over the years, I have rarely had a night when the water chamber did not run dry before my alarm clock sounded.