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One common cause of muscle aches and pain is fibromyalgia, a condition that causes tenderness in your muscles and surrounding soft tissue, sleep difficulties, fatigue, and headaches.
Systemic muscle pain â pain throughout your whole body â is more often the result of an infection, an illness or a side effect of a medication. Common causes of muscle pain include: 1  Chronic exertional compartment syndrome.  Chronic fatigue syndrome.