The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Survivors: he is survived by his wife of 40 years, Virginia Godfrey Maholick; sisters, Geraldine White, Dorothy Maholick; and a brother, Stephen Maholick. Services: 7 p.m. Friday, GIMINSKI-WYSOCKI FUNERAL HOME. Friends may call upon the family from 3 to 7 p.m. Friday, 1320 W. Genesee St., Syracuse, NY 13204.