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The zone that would be most difficult for a plant to live in is the  Benthic zone. It is the zone at the lowest level of a body of  water.
Lack of oxygen is one of the major challenges posed by Everest. The oxygen levels at the top are only a third of what they are at sea level. Humans cannot survive for any length of time at elevation above 26,000 feet (8000 m), which on Everest is known as the death zone.