The mechanism of action of the mammalian carbonic anhydrase has been studied in depth. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site.
Bio. 1  Born Janick âJanâ Gers on January 27, 1957. 2  Joined Iron Maiden in 1990. 3  Formerly of Gillian, White Spirit.
Betty Broderick. Elisabeth Anne Betty Broderick (born November 7, 1947) is an American former suburban housewife convicted of the November 5, 1989 murders of her ex-husband, Daniel T. Broderick III, and his second wife, Linda (Kolkena) Broderick.