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The zone that would be most difficult for a plant to live in is the  Benthic zone. It is the zone at the lowest level of a body of  water.
If tissue pH deviates too far to the acid side, oxygen levels decrease and cells die. On the other side of the coin, it is virtually impossible for a health disorder or disease to sustain itself when your pH is in the neutral zone (7.0-7.4). At this level, the body has a strong immunity to diseases.