â¢ Type II variation: a change which is not an extension and which. may have a significant effect on the quality, safety or efficacy of. the medicinal product concerned (validated and assessed) â¢ Line extension: a change which is listed in Annex I of the Regulation.
Gonorrhea is another common bacterial STD. People often get it with chlamydia, and the symptoms are similar: unusual discharge from the vagina or penis, or pain or burning when you pee. Most men with gonorrhea get symptoms, but only about 20% of women do.
Chlamydia Symptoms. â¢ Symptoms in Men: Pain during urination, pain in the testicles, penis tip discharge. â¢ Symptoms in Women: abnormal vaginal discharge, pain during sexual intercourse, bleeding during and after coitus, heavier periods in comparison with usual, bleeding between periods.