To use all features of KLM.com safely, we recommend that you update your browser, or that you choose a different one. Continuing with this version may result in parts of the website not being displayed properly, if at all.
Neurochemical Factors in Bipolar Disorder. Bipolar disorder is primarily a biological disorder that occurs in a specific area of the brain and is due to the dysfunction of certain neurotransmitters, or chemical messengers, in the brain.nvironmental Factors in Bipolar Disorder. 1  A life event may trigger a mood episode in a person with a genetic disposition for bipolar disorder. 2  Even without clear genetic factors, altered health habits, alcohol or drug abuse, or hormonal problems can trigger an episode.
Causes. There's no known clear cause of oppositional defiant disorder. Contributing causes may be a combination of inherited and environmental factors, including: 1  Genetics â a child's natural disposition or temperament and possibly neurobiological differences in the way nerves and the brain function.here's no known clear cause of oppositional defiant disorder. Contributing causes may be a combination of inherited and environmental factors, including: 1  Genetics â a child's natural disposition or temperament and possibly neurobiological differences in the way nerves and the brain function.