The fat pad in your knee sits just below your knee cap and provides cushioning and shock absorption between the bones of your knee joint. It is also known as Hoffaâs pad and is one of the most sensitive components of your knee joint. Pain is most often caused by the fat pad becoming pinched between the end of your thigh bone and your kneecap.
For example, amitriptyline can cause nervousness, insomnia, and anxiety in some patients because it can stimulate the nervous system. In addition, amitriptyline can also block the effects of a chemical known as acetylcholine, which is used by nerves to control muscles, eMedTV reports.
Amitriptyline is a tricyclic antidepressant also used to treat pain and sleep problems. The higher doses (100 mg plus) are for depression; lower doses for pain and sleep. For it to impact pain or depression requires a period of time; for sleep, a single 25 mg dose can work like a charm.