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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Other possible side effects of metformin include headache, nausea, vomiting, change in taste and loss of appetite, muscle pain and flushing or increased sweating. It's also possible to have an allergic reaction to metformin. Symptoms of a severe allergic reaction include an itchy skin rash with hives, shortness of breath and difficulty breathing, along with swelling of the face, tongue and throat.