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An opiate is a chemical substance that is derived directly from the opium poppy resin and bind to the opioid receptor in the brain. Examples include codeine and opium. Opioids are chemicals that are synthesized or synthetically modified opiates that also bind to the brainâs opioid receptor.n opiate is a chemical substance that is derived directly from the opium poppy resin and bind to the opioid receptor in the brain. Examples include codeine and opium. Opioids are chemicals that are synthesized or synthetically modified opiates that also bind to the brainâs opioid receptor.
2) Semi-synthetic opioid's-these drugs are NOT naturally occurring substances and are NOT opiates. Examples include hydrocodone, oxycodone, oxymorphone, hydromorphone, and diacetylmorphine (heroin).These drugs are built on opiates and have similar chemical structures.) Semi-synthetic opioid's-these drugs are NOT naturally occurring substances and are NOT opiates. Examples include hydrocodone, oxycodone, oxymorphone, hydromorphone, and diacetylmorphine (heroin).