â¢ Type II variation: a change which is not an extension and which. may have a significant effect on the quality, safety or efficacy of. the medicinal product concerned (validated and assessed) â¢ Line extension: a change which is listed in Annex I of the Regulation.
Gonorrhea is another common bacterial STD. People often get it with chlamydia, and the symptoms are similar: unusual discharge from the vagina or penis, or pain or burning when you pee. Most men with gonorrhea get symptoms, but only about 20% of women do.
sexually transmitted diseases std facts stds are infections that are transmitted during any type of sexual contact many stds in women do not cause specific symptoms common stds in women include chlamydia gonorrhea hpv and genital herpes