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In addition to an increase level of TSH above 2.5 mU/L during the first trimester, and above 3 mU/L in the second and third trimester, a decrease fT4 concentration (also using reference range for pregnant women) will help clinicians diagnose overt hypothyroidism during pregnancy.
During pregnancy, a 30%-40% increased need for thyroid hormones is the result of increased placental uptake, higher thyroid-binding globulin levels, and greater blood volume.n addition, it has been shown that women with normal thyroid-stimulating hormone (TSH) levels, but with evidence for thyroid autoimmunity, are at approximately a 2-fold increased risk for pregnancy loss.