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Rhabdomyolysis: A condition in which skeletal muscle is broken down, releasing muscle enzymes and electrolytes from inside the muscle cells. Risks of rhabdomyolysis include muscle breakdown and kidney failure because the cellular component myo-. globin is toxic to the kidneys.
Activation of the coagulation system may precipitate disseminated intravascular coagulation. High potassium levels may lead to potentially fatal disruptions in heart rhythm. Phosphate binds to calcium from the circulation, leading to low calcium levels in the blood. Rhabdomyolysis may cause kidney failure by several mechanisms. The most important is the accumulation of myoglobin in the kidney tubules. Normally, the blood protein haptoglobin binds circulating myoglobin and other heme-containing substances, but in rhabdomyolysis the quantity of myoglobin exceeds the binding capacity of haptoglobin.