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Location. The majority of parathyroid adenomas are juxtathyroid and located immediately posterior or inferior to the thyroid gland. Superior gland parathyroid adenoma may fall posteriorly in the tracheo-oesophageal groove or para-oesophageal location or even fall inferior as far as the mediastinum 12.Up to 5% of parathyroid adenomas can occur in ectopic locations. Common ectopic locations include 1,12 1  : mediastinum.uperior gland parathyroid adenoma may fall posteriorly in the tracheo-oesophageal groove or para-oesophageal location or even fall inferior as far as the mediastinum 12. Up to 5% of parathyroid adenomas can occur in ectopic locations. Common ectopic locations include 1,12 :
The most common cause of excess hormone production is the development of a benign (non-cancerous) tumor in one of the parathyroid glands. This enlargement of one parathyroid gland is called a parathyroid adenoma, and it accounts for 96% of all patients with primary hyperparathyroidism.The most common situation is that one of the parathyroid glands has developed a tumor that is secreting all the hormone.pproximately 3% or 4% of all patients with primary hyperparathyroidism will have an enlargement of all 4 parathyroid glands, a term called parathyroid hyperplasia. In this instance, all of the parathyroid glands become enlarged and produce too much parathyroid hormone.