Sleep: A Dynamic Activity. Until the 1950s, most people thought of sleep as a passive, dormant part of our daily lives. We now know that our brains are very active during sleep. Moreover, sleep affects our daily functioning and our physical and mental health in many ways that we are just beginning to understand.
What Is Otezla (apremilast)? Otezla is the brand name for an oral medication used to treat both plaque psoriasis and active psoriatic arthritis. The active ingredient in Otezla is apremilast. It is a relatively new treatment option that was approved by the US Food and Drug Administration in 2014.
Thus, an inhibitor of PDE4 results in an increase in cAMP, which is similar to CF101's mechanism of action (discussed below). Otezla(R) was approved for the treatment of psoriatic arthritis in March 2014, and then for the treatment of psoriasis in September 2014. The drug was approved for the treatment of psoriasis based on two Phase 3 clinical trials involving over 1,200 patients.