The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. The maximum recommended dose is 100 mg.
Ivan IV, Ivan the Fourth, also known as Ivan the Terrible, was the first ruler of Russia to give himself the title tsar. This happened in 1547. The first czar of Russia was Ivan IV (Grozny) Before that sovereigns of Russia used title The Great Knyaz. Ivan Grozny was the first Russia's sovereign, who officially used the Czar in title. Both part were used together - Czar and the Great Knyaz.
She then orchestrated a coup to overthrow her husband and became the Empress of the Russian Empire in July 1762. Catherine was Czarina for a period of 34 years till her death in November 1796, making her the longest-ruling female leader in the history of Russia. Though she is considered one of the greatest Russian monarchs, the serfs were mostly dissatisfied during her reign leading to a number of revolts, most prominently the Pugachevâs Rebellion of 1773-75.