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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Just to show that everyone is different. I have been on metformin for over 10 years. I have no pain other than that caused by arthritis (x-rays) and fibromyalgia. If I get any unexplained pain I will see what can be done. I only take 1000mg of metformin in the morning these days.