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Ischemia is the medical term for what happens when your heart muscle doesn't get enough oxygen. Ischemia usually happens because of a shortage of blood and oxygen to the heart muscle. It is usually caused by a narrowing or blockage of one or more of the coronary arteries (which supply blood to the heart muscle). In many cases ischemia is a temporary problem.
Chronic oxidative stress is linked to insulin resistance in multiple tissues. Oxidative stress is mediated, in part, by reactive oxygen species produced by multiple cellular processes and controlled by cellular antioxidant mechanisms such as enzymatic scavengers or antioxidant modulators.xcessive ROS production may induce insulin resistance by the activation of stress-activated signaling cascades or by causing damage to mitochondrial proteins and DNA. Multiple enzymatic scavengers are utilized by the cell to limit damage from reactive oxygen species.