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Colon, or colorectal, cancer is cancer that starts in the large intestine (colon) or the rectum (end of the colon). Other types of cancer can affect the colon. These include lymphoma, carcinoid tumors, melanoma, and sarcomas. These are rare. In this article, colon cancer refers to colon carcinoma only.
Differentiation is the grade of the cancer and it is based on how abnormal the cells look under the microscope. Cancers that are higher grade or poorly differentiated tend to be more aggressive â to grow and spread more quickly. Colon cancer is usually divided into 3 grades: 1  Well differentiated (low grade).denocarcinoma is a type of cancer that starts in the cells that form glands making mucus to lubricate the inside of the colon and rectum. This is the most common type of colon cancer.