The fat pad in your knee sits just below your knee cap and provides cushioning and shock absorption between the bones of your knee joint. It is also known as Hoffaâs pad and is one of the most sensitive components of your knee joint. Pain is most often caused by the fat pad becoming pinched between the end of your thigh bone and your kneecap.
For example, amitriptyline can cause nervousness, insomnia, and anxiety in some patients because it can stimulate the nervous system. In addition, amitriptyline can also block the effects of a chemical known as acetylcholine, which is used by nerves to control muscles, eMedTV reports.
Article. AMITRIPTYLINE reduces pain in patients with painful diabetic neuropathy or other neuropathic pain syndromes, 1 2 3 but treatment is often compromised by the sedation, urinary retention, or orthostatic hypotension caused by the drug.n patients with painful diabetic neuropathy we compared the proved effective treatments, amitriptyline and desipramine, to determine whether desipramine might replace amitriptyline as the drug of choice.