â¢ Type II variation: a change which is not an extension and which. may have a significant effect on the quality, safety or efficacy of. the medicinal product concerned (validated and assessed) â¢ Line extension: a change which is listed in Annex I of the Regulation.
Gonorrhea is another common bacterial STD. People often get it with chlamydia, and the symptoms are similar: unusual discharge from the vagina or penis, or pain or burning when you pee. Most men with gonorrhea get symptoms, but only about 20% of women do.
Sometimes there are no symptoms associated with this STI. However, in women, symptoms can include foul smelling or frothy, yellow-green vaginal discharge, vaginal itching or redness, pain during intercourse, lower abdominal discomfort and/or frequent urination.In men, symptoms can include discharge from the penis, frequent urination and/or painful urination.t is transmitted through vaginal, anal or oral sex. Like Chlamydia, this STI is often present without symptoms. However any symptoms would most likely involve penile or vaginal discharge and painful urination.