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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Some of the most common Metformin side effects are: 1  Abnormal stools. 2  Changes in taste. 3  Muscle pain. 4  Difficulty breathing. 5  Lightheadedness or dizziness.6  Nail problems. 7  Flu-like symptoms such as muscle pain, fever, chills, and weakness. 8  Feelings of a rapidly or forcefully beating heart (heart palpitations).ome of the most common Metformin side effects are: 1  Abnormal stools. 2  Changes in taste. 3  Muscle pain. 4  Difficulty breathing. 5  Lightheadedness or dizziness.