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The CRP (C-Reactive Protein) test is a blood test that measures the concentration of a special type of protein produced in the liver. The protein is present during episodes of acute inflammation or infection. In the body, CRP interacts with the complement system, an immunologic defense mechanism.
The standard CRP test measures markedly high levels of the protein to detect diseases that cause significant inflammation. It measures CRP in the range from 10 to 1000 mg/L. The hs-CRP test accurately detects lower levels of the protein than the standard CRP test and is used to evaluate individuals for risk of CVD. It measures CRP in the range from 0.5 to 10 mg/L. It is now believed that a persistent low level of inflammation plays a major role in atherosclerosis, the narrowing of blood vessels due to build-up of cholesterol and other lipids, which is often associated with CVD.