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In fact, we expect that across all humans, there are over 100 mutations at every single position in the human genome. And, here is the math to prove it: The average mutation rate in the human genome is 1.2 x10^-8 mutations per site per generation.This is pretty small, so in each person, we only expect to observe a handful of new mutations relative to their parents.But, that handful of mutations adds up when you think of how many people are on the earth.n fact, we expect that across all humans, there are over 100 mutations at every single position in the human genome. And, here is the math to prove it: The average mutation rate in the human genome is 1.2 x10^-8 mutations per site per generation.
A mutation is a change in a DNA sequence that alters the protein for which the DNA codes. Sometimes mutations occur due to damage from an outside source, such as ultraviolet radiation. Excess ultraviolet radiation from the sun sometimes causes mutations that lead a cell to become cancerous. Most mutations that damage a DNA strand are harmful. Other mutations occur due to deletion or insertion of DNA base pairs. One such deletion in humans confers HIV resistance or a delayed AIDS onset. Humans who are heterozygous for the mutation, meaning they possess one mutant gene and one normal gene, experience a slower progression of AIDS.