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No doubt, Shisui Uchiha had the strongest sharingan. Koto amatsukami is no childs play. Sasuke, Madara and Obito were over powered because of the rinnegans, but Itachi and Shisui were true masters of Mangekyo! Written Nov 5, 2014 Â· View Upvotes.
gfaqs logic: character A beats character B w/o much trouble. 1v1 = Healthy Nagato is the strongest. Itachi would have to use Susanoo immediately, but Nagato has too many options to easily stop Itachi. The ONLY way to beat Nagato is to have a group and even then, one of the people have to have a technique to seal him.