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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Metformin is generally well tolerated. Common side effects include diarrhea, nausea and abdominal pain. It has a low risk of developing low blood sugar. High blood lactic acid level is a concern if the drug is prescribed inappropriately and in overly large doses.