The beta-blockers with low lipid solubility-i.e. atenolol, nadolol and sotalol-are not metabolised, and their dose must be reduced in renal failure. Propranolol has active metabolites and its dose must also be reduced slightly in uraemia.
Despite the Spanish American War being fought in 1898, many important Spanish American War records still exist. The Spanish American War started in 1898 after an explosion on a U.S. ship in Havana Harbor, the USS Maine, was attributed to Spanish sabotage. Although the Spanish American War lasted only 10 weeks, it resulted in the defeat of the Spanish Empire and gave Americans control of Guam, the Philippines and Puerto Rico.
The USS Panay incident was a Japanese attack on the American gunboat Panay while it was anchored in the Yangtze River outside Nanking, China on 12 December 1937. Japan and the United States were not at war at the time. The Japanese claimed that they did not see the American flags painted on the deck of the gunboat, apologized, and paid an indemnity. Nevertheless, the attack and the subsequent Allison incident in Nanking caused U.S. opinion to turn against the Japanese.