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The body stops this blood loss through a complex clotting process called hemostasis. During hemostasis, the injured blood vessel constricts to reduce blood flow, platelets adhere to the injury site and clump (aggregate) together to form a loose platelet plug, and the coagulation cascade is initiated.
Clotting factors are substances in the blood that help the blood to clot. People with hemophilia do not have enough clotting factors. Blood clotting involves two sets of factors. One set works with specialized blood cells made in the bone marrow, called platelets. Platelets play a central role in blood clotting.