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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
In addition, taking metformin in the long run can lead to kidney failure, digestive disease, diarrhea, etc.so, despite of no kidney problems, patients with diabetes should not rely on metformin in the long term. As a consequent, we can know that metformin has side effects on kidney, doing harm to kidney function.