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Answers. Best Answer: Cross-over is a gene swapping process that occurs only in meiosis at prophase-1. Cross-over is one part of gene mixing that leads to the expression of new traits (phenotypes) in development after fertilization. For example: (The two rounds of division ... meiosis 1 and meiosis 2 ...
From Wikipedia, the free encyclopedia. Crossing over occurs between prophase 1 and metaphase 1 and is the process where homologous chromosomes pair up with each other and exchange different segments of their genetic material to form recombinant chromosomes. It can also happen during mitotic division, which may result in loss of heterozygosity.