â¢ Type II variation: a change which is not an extension and which. may have a significant effect on the quality, safety or efficacy of. the medicinal product concerned (validated and assessed) â¢ Line extension: a change which is listed in Annex I of the Regulation.
Gonorrhea is another common bacterial STD. People often get it with chlamydia, and the symptoms are similar: unusual discharge from the vagina or penis, or pain or burning when you pee. Most men with gonorrhea get symptoms, but only about 20% of women do.
Signs and symptoms of chlamydia infection may include: 1  Painful urination. 2  Lower abdominal pain. 3  Vaginal discharge in women. 4  Discharge from the penis in men. 5  Painful sexual intercourse in women. 6  Bleeding between periods and after sex in women. 7  Testicular pain in men.