The beta-blockers with low lipid solubility-i.e. atenolol, nadolol and sotalol-are not metabolised, and their dose must be reduced in renal failure. Propranolol has active metabolites and its dose must also be reduced slightly in uraemia.
Despite the Spanish American War being fought in 1898, many important Spanish American War records still exist. The Spanish American War started in 1898 after an explosion on a U.S. ship in Havana Harbor, the USS Maine, was attributed to Spanish sabotage. Although the Spanish American War lasted only 10 weeks, it resulted in the defeat of the Spanish Empire and gave Americans control of Guam, the Philippines and Puerto Rico.
Amoco Cadiz was a very large crude carrier (VLCC) under the Liberian flag of convenience owned by Amoco. On 16 March 1978, she ran aground on Portsall Rocks, 5 km (3 mi) from the coast of Brittany, France; and ultimately split in three and sank, resulting in the largest oil spill of its kind in history to that date.