Vitamin A is absorbed along with fat in the diet. Take it with food. Studies often use high doses of vitamin A. However, such high doses can be toxic. A doctor should monitor any high-dose therapy (any dose approaching the level of 10,000 IU for an adult, or above the recommended daily allowance for a child).
Paneth Cell Metaplasia Paneth cell metaplasia is a form of intestinal metaplasia where paneth cells are located outside the small bowel such as seen in colonic paneth cell metaplasia. This is usually seen in the setting of chronic inflammation associated with ulcerative colitis, Crohn's Colitis, diverticulitis, or radiation colitis.
Normal physiological metaplasia-such as that of the endocervix is highly desirable. The medical significance of metaplasia is that in some sites where pathological irritation is present cells may progress from metaplasia, to develop dysplasia, and then malignant neoplasia (cancer).n simplistic terms, it is as if the original cells are not robust enough to withstand the new environment, and so they change into another type more suited to the new environment. If the stimulus that caused metaplasia is removed or ceases, tissues return to their normal pattern of differentiation.