The somatostatin receptor family is a member of the G-protein-coupled receptor superfamily and consists of 5 subtypes each differentially distributed throughout the CNS and periphery. These receptors bind with high affinity to the endogenous polypeptides somatostatin-14, somatostatin-28 and cortistatin, as well as a vast array of synthetic ligands.
What medications are used in the intrathecal pump? For pain relief, the doctor may fill the pump with local anesthetics, adrenergic agonists, opioids, and other agents. The first line treatment for severe pain is morphine and hydromorphone. Other drugs used include Fentanyl and methadone. Does the intrathecal pain pump work?
A space inside the pump called the reservoir holds the medication. Figure 1. The intrathecal pump system consists of a pump/reservoir implanted between the muscle and skin of your abdomen and a catheter that carries pain medication (blue area) from the pump to the spinal cord and nerves. The pump is programmed to slowly release medication over a period of time.