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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
A MediGuard answered. Metformin is excreted primarily through your kidneys. When your kidneys are not working well, metformin can build up in your body and cause a condition called lactic acidosis. Lactic acidosis is a build up of acid in the body which can be life threatening.