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A number of scientific studies have indicated that Tea Tree Oil may be an effective treatment for microbial infections, including fungal toenail infections. However, there is no definitive proof that Tea Tree Oil is an effective treatment for toenail fungus.
APPLIED TO THE SKIN 1  : For nail fungus (onychomycosis): 100% tea tree oil solution applied twice daily for six months. 2  For athleteâs foot (tinea pedis): 25% or 50% tea tree oil solution applied twice daily for one month has been used.3  For acne: 5% tea tree oil gel applied daily. It is unclear if the effects are caused by the tea tree oil alone or the combination of lavender and tea tree oil. 2  Methicillin-resistant Staphylococcus aureus (MRSA) infection. 3  Evidence about the effects of tea tree oil on MRSA infection is unclear.