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No doubt, Shisui Uchiha had the strongest sharingan. Koto amatsukami is no childs play. Sasuke, Madara and Obito were over powered because of the rinnegans, but Itachi and Shisui were true masters of Mangekyo! Written Nov 5, 2014 Â· View Upvotes.
Itachi Uchiha gained the Mangekyo Sharingan by killing his best friend, Shisui Uchiha. With the Mangekyo Sharingan, Itachi is able to use the three most powerful jutsu of the Uchiha clan. The first is Tsukuyomi, a powerful genjutsu. This jutsu comes out of and puts strain on the left eye.