In 1736, a large area to the north of Philadelphia, embracing the present site of Allentown and what is now Lehigh County, was deeded by 23 chiefs of the five great Indian nations to John, Thomas, and Richard Penn, sons of William Penn.
The surface of rough endoplasmic reticulum is covered with ribosomes, giving it a bumpy appearance when viewed through the microscope. This type of endoplasmic reticulum is involved mainly with the production and processing of proteins that will be exported, or secreted, from the cell.t is the rough endoplasmic reticulum that is directly continuous with the nuclear envelope (as illustrated in Figure 1), which is also studded with ribosomes, and the two organelles are thought to have evolved simultaneously in ancient cells.
1 The subunits of the ribosome are synthesized by the nucleolus. 2  The subunits of ribosomes join together when the ribosomes attaches to the messenger RNA during the process of protein synthesis. 3  Ribosomes along with a transfer RNA molecule (tRNA), helps to translate the protein-coding genes in mRNA to proteins.ibosome Structure. 1  Ribosomes in a cell are located in two regions of the cytoplasm. 2  They are found scattered in the cytoplasm and some are attached to the endoplasmic reticulum. 3  When the ribosomes are bound to the ER there are known as the rough endoplasmic reticulum.