The fat pad in your knee sits just below your knee cap and provides cushioning and shock absorption between the bones of your knee joint. It is also known as Hoffaâs pad and is one of the most sensitive components of your knee joint. Pain is most often caused by the fat pad becoming pinched between the end of your thigh bone and your kneecap.
For example, amitriptyline can cause nervousness, insomnia, and anxiety in some patients because it can stimulate the nervous system. In addition, amitriptyline can also block the effects of a chemical known as acetylcholine, which is used by nerves to control muscles, eMedTV reports.
Amitriptyline comes in tablet form. The dosing is at night, however, sometimes tablets are prescribed more frequently for pain. Ideally, doses should be timed with bedtime to take advantage of the sedating side effect. The tablets should be taken whole, with water. You may take amitriptyline with or without food.