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No doubt, Shisui Uchiha had the strongest sharingan. Koto amatsukami is no childs play. Sasuke, Madara and Obito were over powered because of the rinnegans, but Itachi and Shisui were true masters of Mangekyo! Written Nov 5, 2014 Â· View Upvotes.
The protagonists of the Naruto series are Naruto Uzumaki, Sasuke Uchiha, Sakura Haruno, and Kakashi Hatake who form Team 7 of Konohagakure. After Sasuke Uchiha's departure from Konohagakure at the end of Part I, the team disbands.