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Basically, the reticular activating system is part of the brainstem. It is believed that ADD/ADHD is caused by a problem in the reticular activating system. The reticular formation is part of the reticular activating system. The reticular formation is a collection of nerve cells, or nuclei, at the core of the brainstem.
The more extensive the subcortical heterotopia, the greater the deficit; bilateral heterotopia are almost invariably associated with severe developmental delay or mental retardation. In general, band heterotopia are seen exclusively in women; men with a mutation of the related gene (called XLIS or DCX ) usually die in utero or have a much more severe brain anomaly.