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To determine âcessation of all functions of the entire brain, including the brain stem,â physicians must determine the presence of unresponsive coma, the absence of brainstem reflexes, and the absence of respiratory drive after a CO 2 challenge.
12 to 15 minutes - irreverseable brain damage intensifies and to heart as well. 15 to 20 minutes - brain damage reaches point to cease brain wave function - death. These times are estimates and can vary based on many factors however the total amount of time to death will not vary by much. Once the oxygen is depleted in the human system, biological death will occur in about 20 minutes. Hope this answers the question.