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No doubt, Shisui Uchiha had the strongest sharingan. Koto amatsukami is no childs play. Sasuke, Madara and Obito were over powered because of the rinnegans, but Itachi and Shisui were true masters of Mangekyo! Written Nov 5, 2014 Â· View Upvotes.
I see, Naruto nodded. The strength of a ascended Dojutsu, the Tenseigan or the Rinnegan, does depend on the strength of the Dojutsu it matures from. However, that is not the most powerful pair of Byakugan.Two have that claim. The Tenseigan that I got from Hamura were the strongest Byakugan.hose two are the base of the Great Dojutsu and the Tenseigan. The Rinnegan, can be formed only by combining the bloodlines of the Senju and the Uchiha. I'm not sure if Uzumaki could be a replacement for the Senju. As for the Tenseigan, it is a bit more tricky.