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The first act of the play is full of Antony s loyalty to Caesar. Antony s attitude can be summed up with what he says in act I, Scene II, line 10: When Caesar says do this, it is performed.. In Act V, Antony s driving motivation seems to be the revenge of Caesars death.
Certainly, she was intelligent, a good diplomat, and queen of an area important for Rome, so it is no wonder that leaders of Rome like Caesar and Mark Antony, would fall in love with Cleopatra, while another Roman leader, Octavian (the future Emperor Augustus), would fear and revile her.