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In fact, we expect that across all humans, there are over 100 mutations at every single position in the human genome. And, here is the math to prove it: The average mutation rate in the human genome is 1.2 x10^-8 mutations per site per generation.This is pretty small, so in each person, we only expect to observe a handful of new mutations relative to their parents.But, that handful of mutations adds up when you think of how many people are on the earth.n fact, we expect that across all humans, there are over 100 mutations at every single position in the human genome. And, here is the math to prove it: The average mutation rate in the human genome is 1.2 x10^-8 mutations per site per generation.
Mutations are defined as random changes in cellular DNA. They change the genetic code for amino acid sequence in proteins, thus introducing biochemical errors of varying degrees of severity. Mutations have been classified as deletions (loss of DNA bases), insertions (gain of DNA bases), and missense or nonsense (substitution of a DNA base). If the mutations affect germ cells (female ova and male spermatozoa), they will be passed to all the cells of the offspring, and affect future generations. Such mutations are called âgermline mutations,â and are the cause of inherited diseases.