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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Symptoms of lactic acidosis include weakness, sleepiness, slow heart beat, feeling cold, muscle pain, shortness of breath, loss of consciousness, etc. Although metformin does not directly cause kidney damage, the patients who have kidney damage and or kidney disease should not use the medicine. Another significant complication of metformin is Acute Kidney Failure. Gastrointestinal problems such as, significant diarrhea or vomiting commonly occur in people who are taking metformin therapy when there is underlying chronic kidney disease. It can lead to severe dehydration and acute renal failure.