The paintings of the Italian Renaissance differed from those of the Northern Renaissance. Italian Renaissance artists were among the first to paint secular scenes, breaking away from the purely religious art of medieval painters.
Sickle cell anaemia is caused by a genetic mutation that affects the normal development of haemoglobin. A genetic mutation is a permanent change in the normal pattern of genetic information inside all living cells. This results in one or more of the body's processes not working properly.
Sickle cell disease occurs from genetic changes that cause abnormalities in hemoglobin molecules: 1  Hemoglobin A (HbA) . 2  HbA is the hemoglobin molecule found in normal red blood cells during childhood and adulthood. 3  People who do not have sickle cell disease generally have this type of hemoglobin in their blood cells.ickle cell disease is an inherited blood disorder in which the body produces abnormally shaped red blood cells. In sickle cell disease, the hemoglobin in red blood cells clumps together. This causes red blood cells to become stiff and C-shaped.