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With just one treatment, isotretinoin can permanently clear the skin. One treatment typically lasts 4 to 5 months. If a dermatologist prescribes a lower dose of isotretinoin, the treatment may last longer. About 85% of patients see permanent clearing after one treatment.
Accutane (isotretinoin) is a powerful drug that can cause severe, life-threatening birth defects if the mother takes the medication during pregnancy . Even one dose of Accutane can cause major birth defects of the baby's ears, eyes, face, skull, heart, and brain.