1 A cubic yard of driveway-grade crushed gravel costs about $10 -$60 or more, depending on whether it is picked up by the customer at the gravel yard or delivered to the job site, and the size and type of gravel used.( 2 A cubic yard of gravel is 3'x3'x3' and weighs roughly 1.2 to 1.7 tons or more). (A cubic yard of gravel is 3'x3'x3' and weighs roughly 1.2 to 1.7 tons or more). 2  A 12'x25' single-car driveway 9 thick requires an estimated 10-14 tons, which can cost $100 -$850.
HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol. More recent evidence shows it to contain eight transmembrane domains.
Pyruvate enters the Krebs cycle via an intermediate called acetyl CoA. Pyruvate is formed in the cytoplasm as the end product of glycolysis. Pyruvate enters a mitochondrion, in the matrix of which it encounters the enzyme pyruvate dehydrogenase. This enzyme catalyzes the reaction of pyruvate with coenzyme A to form acetyl CoA. This reaction is sometimes called the link reaction, as it links glycolysis to the Krebs cycle (= citric acid cycle, or tricarboxylic acid cycle).