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In addition to an increase level of TSH above 2.5 mU/L during the first trimester, and above 3 mU/L in the second and third trimester, a decrease fT4 concentration (also using reference range for pregnant women) will help clinicians diagnose overt hypothyroidism during pregnancy.
Thyroid hormones continue to increase gradually over the entire period of gestation as does serum thyroxine-binding globulin (TBG) (9,10) . TBG is present at levels of 100 nmol/L (5 mg/L) at gestational age 12 weeks and progressively increases up to the time of birth, reaching concentrations of 500 nmol/L (25 mg/L).