Cardiomegaly can be a hereditary problem, or it may develop if you have a condition that affects your heart function. Most of the time, cardiomegaly develops as a result of a medical condition. An enlarged heart usually results from situations that force the heart to pump harder or that cause damage to the heart muscle. At times the heart may become enlarged and weak for no apparent reason. The most common conditions associated with cardiomegaly include the following: 1  Congenital heart condition - a heart problem present at birth. 2  Heart attack- which weakens a section of the heart muscle. 3  Arrhythmia- an irregular heart rhythm.
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