The somatostatin receptor family is a member of the G-protein-coupled receptor superfamily and consists of 5 subtypes each differentially distributed throughout the CNS and periphery. These receptors bind with high affinity to the endogenous polypeptides somatostatin-14, somatostatin-28 and cortistatin, as well as a vast array of synthetic ligands.
What medications are used in the intrathecal pump? For pain relief, the doctor may fill the pump with local anesthetics, adrenergic agonists, opioids, and other agents. The first line treatment for severe pain is morphine and hydromorphone. Other drugs used include Fentanyl and methadone. Does the intrathecal pain pump work?
Patients often turn toward surgery to âfixâ the problem, but the majority of the time surgery is not indicated and/or has made the initial pain worse. Intrathecal pump therapy is a treatment option targeted to treating your chronic pain at the source where your pain is perceived in your spinal cord. It is meant to decrease your pain by at least 50% while at the same time potentially eliminate the need for chronic medication use.