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The body stops this blood loss through a complex clotting process called hemostasis. During hemostasis, the injured blood vessel constricts to reduce blood flow, platelets adhere to the injury site and clump (aggregate) together to form a loose platelet plug, and the coagulation cascade is initiated.
(See also Overview of Blood Clotting Disorders.) Disseminated intravascular coagulation is a condition in which small blood clots develop throughout the bloodstream, blocking small blood vessels. The increased clotting depletes the platelets and clotting factors needed to control bleeding, causing excessive bleeding. There are a number of possible causes, including infection and surgery. Excessive clotting is followed by excessive bleeding. The amount of clotting factors in the blood is measured.