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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Metformin long term side effects. Common Questions and Answers about Metformin long term side effects. glucophage. Yes, one nasty side effect of Metformin is nausea. He should have been aware of this from reading the pharmaceutical paperwork that accompanied the Metformin bottle, or by his Pharmacist.