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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Through the above analysis, we can see metformin itself can not induce kidney failure, but its side effect can become a main cause of kidney damage. In addition, the drug can also cause other side effects, especially gastrointestinal distress.etformin is an oral antidiabetic drug and it is the first-line drug of choice for the treatment of type 2 diabetes, in particalar in overweight and obese people and those with normal kidney function.