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Neurochemical Factors in Bipolar Disorder. Bipolar disorder is primarily a biological disorder that occurs in a specific area of the brain and is due to the dysfunction of certain neurotransmitters, or chemical messengers, in the brain.nvironmental Factors in Bipolar Disorder. 1  A life event may trigger a mood episode in a person with a genetic disposition for bipolar disorder. 2  Even without clear genetic factors, altered health habits, alcohol or drug abuse, or hormonal problems can trigger an episode.
Causes of borderline personality disorder. Most experts agree that there is no single cause of borderline personality disorder (BPD). It is likely to be caused by a combination of factors.These include: 1  genetics â g enes you inherit from your parents may make you more vulnerable to developing BPD, given certain environmental factors (see below).eurotransmitters. It is thought that many people with BPD may have altered functioning of a neurotransmitter called serotonin in their brain. Altered serotonin activity in the brain has been linked to depression, aggression and difficulty in controlling destructive urges.