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To determine âcessation of all functions of the entire brain, including the brain stem,â physicians must determine the presence of unresponsive coma, the absence of brainstem reflexes, and the absence of respiratory drive after a CO 2 challenge.
unresponsive - aloof or indifferent; was unresponsive to her passionate advances. cool - psychologically cool and unenthusiastic; unfriendly or unresponsive or showing dislike; relations were cool and polite; a cool reception; cool to the idea of higher taxes.