The beta-blockers with low lipid solubility-i.e. atenolol, nadolol and sotalol-are not metabolised, and their dose must be reduced in renal failure. Propranolol has active metabolites and its dose must also be reduced slightly in uraemia.
Despite the Spanish American War being fought in 1898, many important Spanish American War records still exist. The Spanish American War started in 1898 after an explosion on a U.S. ship in Havana Harbor, the USS Maine, was attributed to Spanish sabotage. Although the Spanish American War lasted only 10 weeks, it resulted in the defeat of the Spanish Empire and gave Americans control of Guam, the Philippines and Puerto Rico.
The USS Oklahoma sits in water in Pearl Harbor, Hawaii, on March 29, 1943, while under salvage. It was attacked on Dec. 7, 1941. (U.S. Navy photo) The destruction of the USS Oklahoma came quickly. On Dec. 7, 1941, it was hit with numerous torpedoes and bombs during Japanâs fierce and shocking bombardment of Pearl Harbor, capsizing within minutes with hundreds of Marines and sailors inside.