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Neurochemical Factors in Bipolar Disorder. Bipolar disorder is primarily a biological disorder that occurs in a specific area of the brain and is due to the dysfunction of certain neurotransmitters, or chemical messengers, in the brain.nvironmental Factors in Bipolar Disorder. 1  A life event may trigger a mood episode in a person with a genetic disposition for bipolar disorder. 2  Even without clear genetic factors, altered health habits, alcohol or drug abuse, or hormonal problems can trigger an episode.
1 Bipolar II involves less severe manic episodes than bipolar I; however, their depressive episodes are the same. 2  Cyclothymia is a chronic but milder form of bipolar disorder, characterized by episodes of hypomania and depression that last for at least two years.here is no single cause for bipolar disorder. Indeed, like all psychological disorders, bipolar disorder is a complex condition with multiple contributing factors, including: 1  Genetic: Bipolar disorder tends to run in families, so researchers believe there is a genetic predisposition for the disorder.