The somatostatin receptor family is a member of the G-protein-coupled receptor superfamily and consists of 5 subtypes each differentially distributed throughout the CNS and periphery. These receptors bind with high affinity to the endogenous polypeptides somatostatin-14, somatostatin-28 and cortistatin, as well as a vast array of synthetic ligands.
What medications are used in the intrathecal pump? For pain relief, the doctor may fill the pump with local anesthetics, adrenergic agonists, opioids, and other agents. The first line treatment for severe pain is morphine and hydromorphone. Other drugs used include Fentanyl and methadone. Does the intrathecal pain pump work?
The drugs traditionally used in intrathecal chemotherapy are methotrexate and cytarabine. Many authors defend the combined use of methotrexate, cytarabine and glucocorticosteroids, which is called triple intrathecal therapy (TIT). One of the most commonly corticosteroids used in TIT chemotherapy is hydrocortisone.