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Read More. Metformin has been known to cause kidney and liver problems, but this does not happen in all patients, and there is some evidence there is a co-factor, in development of damage, such as alcoholism, or a combination of other drugs. The national database PUBMED has the studies.
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. ... Metformin side effects can also affect other parts of the body. It can leave a metallic taste in the mouth, cause heartburn or headache, flushing of the skin, nail changes or muscle pain. More serious metformin side effects include chest pain or rash. ...