Clinical Significance. The BUN/Creatinine ratio is useful in the differential diagnosis of acute or chronic renal disease. Reduced renal perfusion, e.g., congestive heart failure, or recent onset of urinary tract obstruction will result in an increase in BUN/Creatinine ratio. Increased urea formation also results in an increase in the ratio, e.g., gastrointestinal bleeding, trauma, etc. When there is decreased formation of urea as seen in liver disease, there is a decrease in the BUN/Creatinine ratio. In most cases of chronic renal disease the ratio remains relatively normal.
Early Life. Born in Oklahoma City, Oklahoma, on June 22, 1949, Elizabeth Warren was the last of four childrenâand the only daughterâof Donald and Pauline Herring. Warren spent most of her early life on what she referred to as the ragged edge of the middle class..
Just imagine Elizabeth Warren as President and later establishing a Presidential Library & Museum in Oklahoma City her birthplace. Boston has a presidential library; just imagine one on I-35/I-40 route near the Bombing Museum or AICCM in OKC.