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To determine âcessation of all functions of the entire brain, including the brain stem,â physicians must determine the presence of unresponsive coma, the absence of brainstem reflexes, and the absence of respiratory drive after a CO 2 challenge.
| Getty. When a patient's brain falls completely silent, and electrical recordings devices show a flat line, reflecting a lack of brain activity, doctors consider the patient to have reached the deepest stage of a coma. Getty. When a patient's brain falls completely silent, and electrical recordings devices show a flat line, reflecting a lack of brain activity, doctors consider the patient to have reached the deepest stage of a coma.