â¢ Type II variation: a change which is not an extension and which. may have a significant effect on the quality, safety or efficacy of. the medicinal product concerned (validated and assessed) â¢ Line extension: a change which is listed in Annex I of the Regulation.
Gonorrhea is another common bacterial STD. People often get it with chlamydia, and the symptoms are similar: unusual discharge from the vagina or penis, or pain or burning when you pee. Most men with gonorrhea get symptoms, but only about 20% of women do.
Physical symptoms of PID include: 1  Painful urination. 2  Abnormal yellow or green vaginal discharge accompanied by an unusual odor. 3  Vaginal bleeding between periods. 4  Pain during sexual intercourse. 5  Chills or high fever. 6  Nausea or vomiting. 7  Pain or tenderness in the lower abdomen or lower back. 8  Fainting or other signs of shock.