The somatostatin receptor family is a member of the G-protein-coupled receptor superfamily and consists of 5 subtypes each differentially distributed throughout the CNS and periphery. These receptors bind with high affinity to the endogenous polypeptides somatostatin-14, somatostatin-28 and cortistatin, as well as a vast array of synthetic ligands.
What medications are used in the intrathecal pump? For pain relief, the doctor may fill the pump with local anesthetics, adrenergic agonists, opioids, and other agents. The first line treatment for severe pain is morphine and hydromorphone. Other drugs used include Fentanyl and methadone. Does the intrathecal pain pump work?
The intrathecal pump is a small device that is surgically implanted under the skin. This device has a tiny battery-powered pump that is programmable and refillable. The nurse refills the pump every 1-3 months using a syringe and needle. The pump is connected to an intrathecal catheter that delivers tiny concentrated amounts of pain medicine to the spinal fluid. How is the intrathecal pump implanted? Before the permanent device is implanted, the pain management specialist will have you take an epidural trial.