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An opiate is a chemical substance that is derived directly from the opium poppy resin and bind to the opioid receptor in the brain. Examples include codeine and opium. Opioids are chemicals that are synthesized or synthetically modified opiates that also bind to the brainâs opioid receptor.n opiate is a chemical substance that is derived directly from the opium poppy resin and bind to the opioid receptor in the brain. Examples include codeine and opium. Opioids are chemicals that are synthesized or synthetically modified opiates that also bind to the brainâs opioid receptor.
A tolerance to opiods (opiods are a type of synthetic opiate-examples of opiods include Demerol (pethidine) and Methadone) will also result in tolerance to opiates and vice versa.