Clinical Significance. The BUN/Creatinine ratio is useful in the differential diagnosis of acute or chronic renal disease. Reduced renal perfusion, e.g., congestive heart failure, or recent onset of urinary tract obstruction will result in an increase in BUN/Creatinine ratio. Increased urea formation also results in an increase in the ratio, e.g., gastrointestinal bleeding, trauma, etc. When there is decreased formation of urea as seen in liver disease, there is a decrease in the BUN/Creatinine ratio. In most cases of chronic renal disease the ratio remains relatively normal.
Early Life. Born in Oklahoma City, Oklahoma, on June 22, 1949, Elizabeth Warren was the last of four childrenâand the only daughterâof Donald and Pauline Herring. Warren spent most of her early life on what she referred to as the ragged edge of the middle class..
Who is Mary Elizabeth Winstead? Mary Elizabeth Winstead is an American actress and singer, best known as a scream queen for her role in such horror films as Final Destination 3, The Thing: The Beginning and Black Christmas. Mary Elizabeth Winsteadâs Early life, Childhood, and Education Mary Elizabeth Winstead was born on November 28, 1984, in Rocky Mount, North Carolina, United States. Her dad was James Ronald Winstead and her mom was Betty Lou, she was the most youthful of their five youngsters.