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Location. The majority of parathyroid adenomas are juxtathyroid and located immediately posterior or inferior to the thyroid gland. Superior gland parathyroid adenoma may fall posteriorly in the tracheo-oesophageal groove or para-oesophageal location or even fall inferior as far as the mediastinum 12.Up to 5% of parathyroid adenomas can occur in ectopic locations. Common ectopic locations include 1,12 1  : mediastinum.uperior gland parathyroid adenoma may fall posteriorly in the tracheo-oesophageal groove or para-oesophageal location or even fall inferior as far as the mediastinum 12. Up to 5% of parathyroid adenomas can occur in ectopic locations. Common ectopic locations include 1,12 :
Primary hyperparathyroidism occurs when your parathyroid glands produce too much PTH. This can happen if you have an adenomaâor non-cancerous tumorâon one of these glands. These tumors are the most common cause of primary hyperparathyroidism. In other cases, enlargement of at least two of your parathyroid glands can lead to this condition. Doctors often do not understand what causes this enlargement. In rare cases, parathyroid cancer may be the culprit. These tumors can cause hyperparathyroidism.