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To determine âcessation of all functions of the entire brain, including the brain stem,â physicians must determine the presence of unresponsive coma, the absence of brainstem reflexes, and the absence of respiratory drive after a CO 2 challenge.
Coma is defined as a sleep-like, unarousable, unresponsive state. Other. patients with impaired consciousness but some limited degree of responding are. described as obtunded or stuporous. In coma, only brain stem reflexes are clinically. testable, since cortical function is absent.