â¢ Type II variation: a change which is not an extension and which. may have a significant effect on the quality, safety or efficacy of. the medicinal product concerned (validated and assessed) â¢ Line extension: a change which is listed in Annex I of the Regulation.
Gonorrhea is another common bacterial STD. People often get it with chlamydia, and the symptoms are similar: unusual discharge from the vagina or penis, or pain or burning when you pee. Most men with gonorrhea get symptoms, but only about 20% of women do.
Top 10 Doctor insights on: Dry Mouth Std Symptoms. 1 Hello I m suffering with fever dry mouth swollen nodes from 2 yrs, these are started after sex with unknown. All STD neg. my wife also same sym, help. Not an STD: No STD or any other infection from sexual contact is a likely cause of such symptoms.