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With just one treatment, isotretinoin can permanently clear the skin. One treatment typically lasts 4 to 5 months. If a dermatologist prescribes a lower dose of isotretinoin, the treatment may last longer. About 85% of patients see permanent clearing after one treatment.
After the 25 days are over, no pills are taken for three to five days. There also is continuous, combined therapy in which estrogen and progestin are taken together every day. A hormone replacement therapy patch is also available, and women also may be given a vaginal cream with estrogen for vaginal dryness.