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With just one treatment, isotretinoin can permanently clear the skin. One treatment typically lasts 4 to 5 months. If a dermatologist prescribes a lower dose of isotretinoin, the treatment may last longer. About 85% of patients see permanent clearing after one treatment.
After the surgery I waited 10hrs after my last dose of Dilauded to  take 2mg of Suboxone and i was fine. So after all my rambling to a  long story short, if you are going to need opiates you should stay  off the sub's for at least 48hrs longer if you can.