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Top 10 Doctor insights on: How To Flush Macrobid Out Of System. 1 How long does Macrobid stay in your system after taking the last dosage? 24hours: Half life is 12 hours. That means the half of the total dose taken will be gone after 12 hours and then another 12 hours 50% from the other half will be gone and so forth.
Common side effects. The more common side effects of Macrobid can include: nausea ; vomiting; headache; gas; diarrhea; constipation; Serious side effects. In some cases, Macrobid can cause serious side effects. These can include: Serious allergic reaction. Symptoms can include: hives or rash; trouble breathing or swallowing; swelling of your lips, tongue, or face