In patients with asthma, the total clearance offenoterol was 63 Â± 24 L/h and the steady-state volume of distribution was 140 Â± 70 L (62).Hochhaus et al. (62) suggested linear pharmacokinetics for fenoterol. There are nopublished pharmacokinetic studies with long-term use of fenoterol.
Toenail fungus, or onychomycosis, is an infection underneath the surface of the nail caused by fungi. When the tiny organisms take hold, the nail often becomes darker in color and smells foul. Debris may collect beneath the nail plate, white marks frequently appear on the nail plate, and the infection is capable of spreading to other toenails, the skin, or even the fingernails.
A bacterial infection can cause thickening, and this can arise due to some trauma to the nail. Possible Causes of Crumbling & Dry Toenails. Our toenails contain something called keratin. A toenail fungus will feed on keratin, which is what makes our nails dry and crumbling when we have an untreated fungus.