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The tricyclic antidepressants (TCA's) help with. diarrhea and the serotonin reuptake inhibitors (SSRI's) help treat constipation. Furthermore, these. medicines can help with other problems such as anxiety and depression, which are often associated. with chronic painful disorders.
Tricyclic antidepressants differ in their relative effects on serotonin, norepinephrine, and acetylcholine. The differences are reflected in how the tricyclic antidepressants are used and, most importantly, their propensity to cause certain side effects.For instance, amitriptyline (Elavil) causes more sedation, dry mouth, and constipation than other tricyclic antidepressants.he differences are reflected in how the tricyclic antidepressants are used and, most importantly, their propensity to cause certain side effects. For instance, amitriptyline (Elavil) causes more sedation, dry mouth, and constipation than other tricyclic antidepressants.