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Anemia is a condition in which there aren't enough healthy red blood cells to carry adequate oxygen to the body's tissues. Tiredness can be a symptom of anemia. But unless it is quite severe, anemia is rarely the cause of persistent fatigue in children. In your child's situation, I suggest first confirming that he or she is, indeed, getting at least 10 hours of restful sleep each night.
If bowing of the legs persists or increases despite the use of a brace, surgery may be needed. Braces are not effective in adolescent Blount's Disease, and teens with the condition are usually treated with surgery. Other, rarer conditions may also result in bowed legs in toddlers. Disorders of metabolism such as rickets (a deficiency of vitamin D that is rare in developed countries) can also lead to bowed legs.