1 If you are unhappy with your tattoo, having it altered or tattooed over might cost hundreds of dollars and removal is even more expensive-up to $10,000 in some cases. And some artists will charge extra for custom designs, but it is more common to ask for a deposit of about $50. 2  If you are unhappy with your tattoo, having it altered or tattooed over might cost hundreds of dollars and removal is even more expensive-up to $10,000 in some cases.
1 Single gene disorders are caused by a mutation in a single gene. 2  The mutation may be present on one or both chromosomes (one chromosome inherited from each parent). 3  Sickle cell disease, cystic fibrosis and gCJD are examples of single gene disorders.
Since two copies of the mutant gene cause the disease phenotype, a person can survive with one functional copy, and as such they are termed carriers. Having one functioning copy is sufficient to prevent the disease condition. However, when there are genetic mutations in both copies, the disease will be present.The condition is caused by the inability of the body to transport chloride ions into and out of cells due to the mutated CFTR gene. Gradually this leads to a blockage of the lungs and pancreas.owever, when there are genetic mutations in both copies, the disease will be present. The condition is caused by the inability of the body to transport chloride ions into and out of cells due to the mutated CFTR gene.