Like us on Facebook. Shakespeare coined many of his own words, played around with others, used existing words in new and imaginative contexts, and joined pairs of words together to create compounds like watchdog (in The Tempest) and birthplace (in Coriolanus).he problem with being so linguistically inventive, however, is that sometimes Shakespeare coined or used words in such a way that what he actually wanted them to mean remains unclear.
Substitution mutation. Definition. A type of point mutation in which a single nucleotide is substituted with (or exchanged for) a different nucleotide that may result in an altered sequence of amino acid during translation, which may render the newly synthesized protein ineffective.
Base substitution. Base substitutions are the simplest type of gene-level mutation, and they involve the swapping of one nucleotide for another during DNA replication. For example, during replication, a thymine nucleotide might be inserted in place of a guanine nucleotide.