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Top 10 Doctor insights on: How To Flush Macrobid Out Of System. 1 How long does Macrobid stay in your system after taking the last dosage? 24hours: Half life is 12 hours. That means the half of the total dose taken will be gone after 12 hours and then another 12 hours 50% from the other half will be gone and so forth.
Nitrofurantoin (Macrodantin) is taken for 10 days. You need to give it at least 48 hours. I believe you are taking a once daily dose. Don't skip any doses and take it all.Drink 3 liters of water a day and omit cranberry juice for the time being.'ve been having very bad urinary tract infection for about 1 week (with blood every time I go to the bathroom).I took trimethoprim for 3 days but it didn't get better so the doctor gave me nitrofurantoin..today is the second day and its not improving.