In order to understand why some combinations of alkyl halides and nucleophiles give a substitution reaction, whereas other combinations give elimination, and still others give no observable reaction, we must investigate systematically the way in which changes in reaction variables perturb the course of the reaction.
It's true - the ISS moves at about 17,000 mph (~28,000 kph). Now for your other questions: 1. When it's not using its onboard engines to adjust its orbit, the station is in free-fall*. This means that gravitational interaction with the earth maintains the station's orbit, and thus its speed.
It takes the shuttle approximately 8-1/2 minutes to get to orbit. And if you think about it, we're accelerating a 4-1/2 million pound system from zero miles per hour to its orbital velocity of 17,500 miles per hour in those 8-1/2 minutes. So it's a heck of a ride for the astronauts.