Like us on Facebook. Shakespeare coined many of his own words, played around with others, used existing words in new and imaginative contexts, and joined pairs of words together to create compounds like watchdog (in The Tempest) and birthplace (in Coriolanus).he problem with being so linguistically inventive, however, is that sometimes Shakespeare coined or used words in such a way that what he actually wanted them to mean remains unclear.
Substitution mutation. Definition. A type of point mutation in which a single nucleotide is substituted with (or exchanged for) a different nucleotide that may result in an altered sequence of amino acid during translation, which may render the newly synthesized protein ineffective.
substitute. 1  A replacement or stand-in for something that achieves a similar result or purpose. ( 2 sports) A player who is available to replace another if the need arises, and who may or may not actually do so. ( 3 historical) One who enlists for military service in the place of a conscript.