Demyelinating disease. A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged. This damage impairs the conduction of signals in the affected nerves. In turn, the reduction in conduction ability causes deficiency in sensation, movement, cognition, or other functions depending on which nerves are involved.
For other uses, see Reamer (disambiguation). A reamer is a type of rotary cutting tool used in metalworking. Precision reamers are designed to enlarge the size of a previously formed hole by a small amount but with a high degree of accuracy to leave smooth sides.
A hand reamer has a longer taper or lead in at the front than a machine reamer. This is to compensate for the difficulty of starting a hole by hand power alone. It also allows the reamer to start straight and reduce the risk of breakage. The flutes may be straight or spiral.