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osteoblasts large, granular cells, can't undergo mitosis, found on surface of bone form bone, secrete the osteoid: collagen, proteoglycans, glycoproteins. Osteoblast are cuboidal mononuclear bone cells 15-30 Âµm in length, which form a contiguous monolayer over the surface of bone. They are derived from marrow stromal cells by differentiation of pre-osteoblasts and not themselves undergo mitosis.
Osteoclasts are nondividing, motile, multinucleate cells that resorb bone matrix from bone surfaces. They are derived from monocytes, which fuse with one another or with macrophages to form the multinucleate osteoclasts. Some osteoclasts lie in recesses of the bone surface called Howship s lacunae or resorption bays.s a consequence, the cells of the inner layer of the perichondrium differentiate into osteoblasts and start producing bone matrix. Now the perichondrium is considered a periosteum. Soon there is a collar of bone, called subperiosteal bone, surrounding the midsection of the cartilage.