To evaluate the effect of end-stage renal insufficiency and haemodialysis on the elimination of lorazepam, single oral doses of the drug (2.5 mg) were administered to normal subjects and patients with chronic renal failure (CC(r) : less than 2 ml/min) in the interdialysis period and during haemodialysis.rinary excretion of lorazepam-glucuronide was found to be considerably decreased in chronic renal failure associated with accumulation of high concentrations of this conjugate in plasma during days after a single oral dose. The plasma T1/2 of this conjugate in normals was 20.7 +/- 2.1 h.
A microcosm is a small society, place, or activity which has all the typical features of a much larger one and so seems like a smaller version of it. [formal] Kitchell says the city was a microcosm of all American culture during the '60s.
The symbol Âµm is sometimes rendered as um if the symbol Âµ cannot be used, or if the writer is not aware of the distinction. The micrometre is a common unit of measurement for wavelengths of infrared radiation as well as sizes of biological cells and bacteria and is also commonly used in plastics manufacturing. Micrometres are the standard for grading wool (referring to the diameter of wool fibres).