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osteoblasts large, granular cells, can't undergo mitosis, found on surface of bone form bone, secrete the osteoid: collagen, proteoglycans, glycoproteins. Osteoblast are cuboidal mononuclear bone cells 15-30 Âµm in length, which form a contiguous monolayer over the surface of bone. They are derived from marrow stromal cells by differentiation of pre-osteoblasts and not themselves undergo mitosis.
Osteoblasts are specialized, terminally differentiated products of mesenchymal stem cells. They synthesize very dense, crosslinked collagen, and several additional specialized proteins in much smaller quantities, including osteocalcin and osteopontin, which compose the organic matrix of bone.ndividual cells cannot make bone, and the group of organized osteoblasts together with the bone made by a unit of cells is usually called the osteon; the basis of this is discussed in Organization and ultrastructure of osteoblasts below.