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hemidesmisomes function. anchor the basal membrane of epithelial cells to the basal lamina. hemidesmisomes have integrins which are receptors for proteins of the basal lamina (laminins), allowing the cell to the keratin based intermediate filament. î î. anchor the basal membrane of epithelial cells to the basal lamina. hemidesmisomes have integrins which are receptors for proteins of the basal lamina (laminins), allowing the cell to the keratin based intermediate filament.
1 Basal cells are at the bottom of the epidermis and continually reproduce to form new keratinocytes.  Keratinocytes or squamous cells are in the middle layer of the epidermis and produce keratin, the protein that forms the protective outer layer. Keratin also is used to produce hair and nails.