Demyelinating disease. A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged. This damage impairs the conduction of signals in the affected nerves. In turn, the reduction in conduction ability causes deficiency in sensation, movement, cognition, or other functions depending on which nerves are involved.
For other uses, see Reamer (disambiguation). A reamer is a type of rotary cutting tool used in metalworking. Precision reamers are designed to enlarge the size of a previously formed hole by a small amount but with a high degree of accuracy to leave smooth sides.
Spindle nose on a lathe headstock. The small female taper is a Morse taper to take a lathe center or a tool such as a twist drill. The large male taper takes a lathe chuck, which is retained by the large nut. A machine taper is a system for securing cutting tools or toolholders in the spindle of a machine tool or power tool. A male member of conical form (that is, with a taper) fits into the female socket, which has a matching taper of equal angle.