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osteoblasts large, granular cells, can't undergo mitosis, found on surface of bone form bone, secrete the osteoid: collagen, proteoglycans, glycoproteins. Osteoblast are cuboidal mononuclear bone cells 15-30 Âµm in length, which form a contiguous monolayer over the surface of bone. They are derived from marrow stromal cells by differentiation of pre-osteoblasts and not themselves undergo mitosis.
Background. Osteoblastoma is a rare primary neoplasm of bone, categorized as a benign bone tumor that is closely related to osteoid osteoma. It differs from osteoid osteoma in its ability to grow larger than 2.0 cm in diameter. and its aggressive behavior in bone.steoblastoma may affect any bone, but it most frequently arises within the posterior elements of the vertebral column and long tubular bones. When these tumors develop in the spine, patients may present with neurologic symptoms due to spinal cord or nerve root compression.