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0. Phenobarbital is a barbiturate and will cause a positive test result for barbiturates. Phenytoin (Dilantin) is not a barbiturate; however a metabolite, p-hydroxyphenytoin has minimal cross reactivity on the initial screening test. There is no interfe.... Phenobarbital is a barbiturate and will cause a positive test result for barbiturates. Phenytoin (Dilantin) is not a barbiturate; however a metabolite, p-hydroxyphenytoin has minimal cross reactivity on the initial screening test. There is no interfe...
Abstract. Barbiturates and the related depressant drugs, etazolate and etomidate, inhibited both the binding of [ 3 H]bicuculline methochloride (BMC) to Î³-aminobutyric acid (GABA) receptor sites and the binding of [ 3 H]Î²-carboline-3-carboxylic acid methyl ester (Î²CCM) to benzodiazepine receptor sites in mammalian brain.he barbiturate inhibition of [ 3 H]BMC binding involved a decrease in affinity which at high concentrations of barbiturates results in an effective complete loss of detectable binding. The maximal inhibition of [ 3 H]Î²CCM binding involved a more modest decrease in affinity (increase in K D from 1.35 to 1.85 nM).