However, therapeutic enalaprilat levels can probably be achieved with one fourth of the total cumulative dose of enalapril, administered as enalaprilat at 6-hour intervals. Intravenous enalaprilat stimulated plasma renin activity and decreased immunoreactive plasma angiotensin II and plasma aldosterone concentrations.
Alexander Hamilton: Fast Facts. Alexander Hamilton's support of Thomas Jefferson over Aaron Burr in the 1800 U.S. presidental election eventually led to his own demise. Find out more about the first Secretary of the Treasury in this video.
Hamiltonâs influence caused Burr to be defeated. Before the 1804 election, Alexander Hamilton threatened to withdraw from the Federalist Party if it chose Vice President Aaron Burr as its presidential candidate. When Aaron Burr later ran for governor of New York, Alexander Hamiltonâs influence again led to his defeat. Hamilton considered Burr a political opportunist, declaring: âI feel it is a religious duty to oppose his career.â Aaron Burr took offense and challenged Hamilton to a duel. Considered the most famous duel in American history, they met on the morning of July 11, 1804, at the dueling grounds near Weehawken, New Jersey. Burr shot and mortally wounding Hamilton in the stomach. The duel ended Burrâs career and ended Hamiltonâs life.