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Early symptoms of PV are common physical ailments and can be easily ignored by the patient. However, untreated PV may cause blood clots, which can lead to serious complications. Early symptoms of PV include: 1  fatigue. 2  difficulty breathing. 3  tingling in the hands and feet.
Symptoms of Factor V Leiden include: 1  Having a first DVT or PE before 50 years of age. 2  Having recurring DVT or PE. 3  Having venous thrombosis in unusual sites in the body such as the brain or the liver.  Having a DVT or PE during or right after 1  pregnancy. Having a history of unexplained pregnancy loss in the second or third trimester.