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Early symptoms of PV are common physical ailments and can be easily ignored by the patient. However, untreated PV may cause blood clots, which can lead to serious complications. Early symptoms of PV include: 1  fatigue. 2  difficulty breathing. 3  tingling in the hands and feet.
Signs and symptoms of primary immunodeficiency can include: 1  Frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections. 2  Inflammation and infection of internal organs. 3  Blood disorders, such as low platelet counts or anemia.