Puffiness under the eyes is a common symptom of allergies, lack of sleep, stress, and poor diet. Eyes will become puffy when the skin around the eyes becomes irritated and itchy. People who consume large amounts of alcohol and sodium before bed may wake up with puffy eyes due to water retention.
Alcohol, Benzodiazepines, Barbiturates and other central nervous system depressant drugs act primarily on a neurotransmitter substance known as GABA (Gamma Aminobutyric Acid). GABA is an inhibitory neurotransmitter that makes other neurons less likely to activate.
Chronic alcohol abuse has significant detrimental effects on the human cardiac muscle and one of the putative mechanisms via which alcohol may induce cardiac dysfunction is through the induction of increased oxidative stress.