Like us on Facebook. Shakespeare coined many of his own words, played around with others, used existing words in new and imaginative contexts, and joined pairs of words together to create compounds like watchdog (in The Tempest) and birthplace (in Coriolanus).he problem with being so linguistically inventive, however, is that sometimes Shakespeare coined or used words in such a way that what he actually wanted them to mean remains unclear.
Substitution mutation. Definition. A type of point mutation in which a single nucleotide is substituted with (or exchanged for) a different nucleotide that may result in an altered sequence of amino acid during translation, which may render the newly synthesized protein ineffective.
Knowing a few basic types of mutations can help you understand why some mutations have major effects and some may have no effect at all. Substitution. A substitution is a mutation that exchanges one base for another (i.e., a change in a single chemical letter such as switching an A to a G).Such a substitution could: 1  change a codon to one that encodes a different amino acid and cause a small change in the protein produced.2  For example, sickle cell anemia is caused by a substitution in the beta-hemoglobin gene, which alters a single amino acid in the protein produced.nowing a few basic types of mutations can help you understand why some mutations have major effects and some may have no effect at all. Substitution. A substitution is a mutation that exchanges one base for another (i.e., a change in a single chemical letter such as switching an A to a G).