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Early symptoms of PV are common physical ailments and can be easily ignored by the patient. However, untreated PV may cause blood clots, which can lead to serious complications. Early symptoms of PV include: 1  fatigue. 2  difficulty breathing. 3  tingling in the hands and feet.
People with PV have abnormally high hemoglobin and are at risk for a stroke and progressing to acute myelogenous leukemia (AML). Part of the therapy for PV is phlebotomy. Symptoms, signs and diseases resulting from too much iron (iron overload):