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Alpha-galactosidase is an enzyme, which is derived from the fungus Aspergillus niger. Itâs a homodimeric glycoprotein and it hydrolyzes the terminal alpha-galactosyl moieties (in chemistry moiety is defined as a functional group on a molecule) from glycolipids and glycoproteins.
Classic galactosemia, the most severe form of the disease, is caused by a deficiency in an enzyme called galactose-1-phosphate uridyltransferase.People with classic galactosemia have less than 5% of the normal activity in this enzyme.uarte galactosemia is a much milder form of the disease in which a person has 25 to 50% of the normal amount of galactose-1-phosphate uridyltransferase. People with Duarte galactosemia generally do not suffer any of the symptoms of classic galactosemia.