You may have guessed that satiety is related to satisfy, satiate (meaning to satisfy fully or to excess), or sate (which means to glut or to satisfy to the full). If so, you guessed right. Satiety, along with the others, ultimately comes from the Latin word satis, which means enough..
Vesicant chemotherapy agents can be divided into two categories: DNA binding and DNA non-binding (see Table 1). Vesicants that bind to nucleic acids in DNA (eg, anthracylines) bind to the DNA in the cells of healthy tissue when they extravasate from the vein and promptly cause cell death. DNA-doxorubicin complexes are released from dead cells in the tissue and are taken up by adjacent healthy cells by endocytosis.
Antimetabolite drugs were among the first effective chemotherapeutic agents discovered and are folic acid, pyrimidine or purine analogues. They are characterized by low molecular weights. They have similar structures as naturally occurring molecules used in nucleic acid (DNA and RNA) synthesis. Antimetabolites are similar to chemicals needed for normal biochemical activity, but differ enough so that they interfere with normal cell function. Generally, antimetabolites induce cell death during the S phase of cell growth when incorporated into RNA and DNA or inhibit enzymes needed for nucleic acid production. These agents are used for a variety of cancer therapies including leukemia, breast, ovarian and gastro-intestinal cancers.