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Acetylcholinesterase hydrolyzes the neurotransmitter acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen.
Acetylcholine is a neurotransmitterâa chemical messenger that helps carry signals across a nerve synapse. It was the first neurotransmitter to be discovered, and has been heavily studied. It is also the most abundant neurotransmitter and is present in both the central nervous system and peripheral nervous system.cetylcholine works together with the neurotransmitter dopamine to enable smooth movements. When there is an imbalance between acetylcholine and dopamine, movements can be shaky and uneven, a hallmark of Parkinsonâs disease. References: 1  Alzheimerâs disease medication fact sheet.