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osteoblasts large, granular cells, can't undergo mitosis, found on surface of bone form bone, secrete the osteoid: collagen, proteoglycans, glycoproteins. Osteoblast are cuboidal mononuclear bone cells 15-30 Âµm in length, which form a contiguous monolayer over the surface of bone. They are derived from marrow stromal cells by differentiation of pre-osteoblasts and not themselves undergo mitosis.
Osteoblasts begin the process of forming bone tissue by secreting the osteoid as several specific proteins. When the osteoid becomes mineralized, it and the adjacent bone cells have developed into new bone tissue.Osteoid makes up about fifty percent of bone volume and forty percent of bone weight.It is composed of fibers and ground substance. The predominant fiber-type is Type I collagen and comprises ninety percent of the osteoid.The ground substance is mostly made up of chondroitin sulfate and osteocalcin.hen the osteoid becomes mineralized, it and the adjacent bone cells have developed into new bone tissue. Osteoid makes up about fifty percent of bone volume and forty percent of bone weight. It is composed of fibers and ground substance.