Like us on Facebook. Shakespeare coined many of his own words, played around with others, used existing words in new and imaginative contexts, and joined pairs of words together to create compounds like watchdog (in The Tempest) and birthplace (in Coriolanus).he problem with being so linguistically inventive, however, is that sometimes Shakespeare coined or used words in such a way that what he actually wanted them to mean remains unclear.
Substitution mutation. Definition. A type of point mutation in which a single nucleotide is substituted with (or exchanged for) a different nucleotide that may result in an altered sequence of amino acid during translation, which may render the newly synthesized protein ineffective.
This type of mutation is a change in one DNA base pair that results in the substitution of one amino acid for another in the protein made by a gene. nonsense mutation is also a change in one DNA base pair. Instead of substituting one amino acid for another, however, the altered DNA sequence prematurely signals the cell to stop building a protein.