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Acetylcholinesterase hydrolyzes the neurotransmitter acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen.
Inhibition of Acetylcholinesterase at the Neuromuscular Junction I. Background Acetylcholine is the neurotransmitter used at the neuromuscular junction to generate muscle contractions. Acetylcholine (ACh) is released when an action potential reaches the axon terminus of a motor neuron.his Ca 2+ triggers the movement of ACh filled vesicles to the pre-synaptic nerve cell membrane and the exocytotic release of ACh. ACh then diffuses across the neuromuscular junction and binds to its receptor on the post-synaptic cell membrane (in this case, the plasma membrane of the muscle cell).