Like us on Facebook. Shakespeare coined many of his own words, played around with others, used existing words in new and imaginative contexts, and joined pairs of words together to create compounds like watchdog (in The Tempest) and birthplace (in Coriolanus).he problem with being so linguistically inventive, however, is that sometimes Shakespeare coined or used words in such a way that what he actually wanted them to mean remains unclear.
Substitution mutation. Definition. A type of point mutation in which a single nucleotide is substituted with (or exchanged for) a different nucleotide that may result in an altered sequence of amino acid during translation, which may render the newly synthesized protein ineffective.
A missense mutation is when the change of a single base pair causes the substitution of a different amino acid in the resulting protein.This amino acid substitution may have no effect, or it may render the protein nonfunctional. single base pair substitution that results in the translation of a different amino acid at that position. Definition from: GeneReviews from the University of Washington and the National Center for Biotechnology Information.