To evaluate the effect of end-stage renal insufficiency and haemodialysis on the elimination of lorazepam, single oral doses of the drug (2.5 mg) were administered to normal subjects and patients with chronic renal failure (CC(r) : less than 2 ml/min) in the interdialysis period and during haemodialysis.rinary excretion of lorazepam-glucuronide was found to be considerably decreased in chronic renal failure associated with accumulation of high concentrations of this conjugate in plasma during days after a single oral dose. The plasma T1/2 of this conjugate in normals was 20.7 +/- 2.1 h.
A microcosm is a small society, place, or activity which has all the typical features of a much larger one and so seems like a smaller version of it. [formal] Kitchell says the city was a microcosm of all American culture during the '60s.
A macrosystem is a large system within which microsystems are contained. An example of a part of a law firm's macrosystem is the U.S. court system. macrosystem is a large system within which microsystems are contained. An example of a part of a law firm's macrosystem is the U.S. court system.