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Distance, Gas Consumption and Emission Notes. Distance from Cherokee, NC to Charleston, SC is 308Miles or 496 Km. You can get this distance about 4 hours 54 mins. If you want to planning travel with plane for 270 Miles or 434 Km, You can get this distance about 1 hours 4 mins . A car with an average MPG will needs 14.26 gallons of gas to get the route between these points.
How Far Is? Â» South Carolina (SC) Â» Charleston Â» South Carolina (SC) Â» Columbia