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osteoblasts large, granular cells, can't undergo mitosis, found on surface of bone form bone, secrete the osteoid: collagen, proteoglycans, glycoproteins. Osteoblast are cuboidal mononuclear bone cells 15-30 Âµm in length, which form a contiguous monolayer over the surface of bone. They are derived from marrow stromal cells by differentiation of pre-osteoblasts and not themselves undergo mitosis.
1 Osteoblasts. 2  Cells that are derived from osteoprogenitor cells and are responsible for the synthesis of the organic components of bone matrix, which is called osteoid. 3  They are located on the surface of bone tissue and resemble epithelium. Endosteum: Thin layer of osteoprogenitor cells, osteoblasts and a small amount of connective tissue that lines all internal surfaces of cavities within bone including the osteonic canals and marrow spaces. 2  Bone Matrix. 3  Mature bone is made up of approximately 70% inorganic salts and 30% organic matrix by weight.