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Top 10 Doctor insights on: How To Flush Macrobid Out Of System. 1 How long does Macrobid stay in your system after taking the last dosage? 24hours: Half life is 12 hours. That means the half of the total dose taken will be gone after 12 hours and then another 12 hours 50% from the other half will be gone and so forth.
2. Get help from a doctor now âº. Would avoid: Alcohol and Macrobid are broken down by the same protein in the liver so the alcohol may cause the Macrobid not to work as well or even cause it to be too much in the system depending if u drink in short spurts or daily....Read more. Dr. Bret Boyle Board Certified 22 years in practice 264K people helped.. Get help from a doctor now âº. Would avoid: Alcohol and Macrobid are broken down by the same protein in the liver so the alcohol may cause the Macrobid not to work as well or even cause it to be too much in the system depending if u drink in short spurts or daily.