Nevertheless, with terrifying charts and dire warnings, officials continue to say that in 2013, twice as many Haitians as last year â some 1.5 million people â continue to face âsevereâ or âacute food insecurity,â and that many millions more are considered food insecure.
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Mechanism of Action. Entresto is a combination of sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Entresto inhibits neprilysin (neutral endopeptidase; NEP) via LBQ657, the active metabolite of the prodrug sacubitril, and blocks the angiotensin II type-1 (AT1) receptor via valsartan.