1 A problem with the adrenal glands or pituitary gland. A high level of ACTH and a low level of cortisol (or low ACTH and high cortisol levels) could be caused by a problem with the adrenal glands. Low levels of ACTH and cortisol could be caused by a problem with the pituitary gland.  Overproduction of ACTH.
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Interesting Lincoln Memorial Facts: 1  Abraham Lincoln was one of the most cherished of the United States' presidents. 2  Abraham Lincoln was instrumental in leading the U.S. through one of its most troubled periods, and the Civil War. 3  Abraham Lincoln was assassinated by John Wilkes Booth, an actor and Confederate sympathizer, on April 14th, 1865.