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Top 10 Doctor insights on: How To Flush Macrobid Out Of System. 1 How long does Macrobid stay in your system after taking the last dosage? 24hours: Half life is 12 hours. That means the half of the total dose taken will be gone after 12 hours and then another 12 hours 50% from the other half will be gone and so forth.
They did a test on me (not sure what it's called) where they put a cathader in and filled my bladder with liquid, and watched it drain on an ultra sound. The urologist put me on 1 dose of macrobid in the morning for the last year, but just took me off this past August. during that year, I didn't get one UTI, since they took me off, I've had 11! The weird part is, i'm testing Negative for a positive UTI (most times) even though I KNOW I have one.