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Top 10 Doctor insights on: How To Flush Macrobid Out Of System. 1 How long does Macrobid stay in your system after taking the last dosage? 24hours: Half life is 12 hours. That means the half of the total dose taken will be gone after 12 hours and then another 12 hours 50% from the other half will be gone and so forth.
Macrobid is the brand name for nitrofurantoin, an antibiotic used to treat or prevent urinary tract infections.Macrobid works by killing the bacteria that cause the infection or by preventing the bacteria from growing.he recommended dose of Macrobid is different depending on whether it is being used to treat a urinary tract infection or prevent one. In general, here are the ranges of oral doses given: 1  50 to 100 milligrams (mg) at bedtime for adults and teens to prevent infections.