Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Discs that have degenerated (broken down) over time and degenerative arthritis of the spine bones (vertebrae) are the most common causes of chronic low back pain. Aside from sprains, strains and spasms, some of the more common conditions causing LBP include: