Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
It is a reflex, and although the body's response of muscle spasm is not necessary for the safety of the nerve roots, it can be quite painful. The muscle spasms associated with the instability are thought to cause the flare-ups of intense pain often associated with degenerative disc disease.Article continues below.nflammation. The proteins contained within the disc space can cause a lot of inflammation, and as a general rule inflammation will cause pain. 1  In the lumbar disc space, the low back pain can radiate into the hips.