Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Causes of radiating back pain Radiating back pain is typically the result of a compressed nerve in the lumbar (lower) spine. The spinal nerves are responsible for sending sensory signals between the brain and the rest of the body. When one of these nerves is compressed or irritated, it can cause signals of pain and other symptoms to travel throughout the lower back and into the lower extremities, including the hips, buttocks and legs.