Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Long-lasting (chronic) pain not only makes you tired, irritable, and less productive and less active but also can trigger other problems. If your back pain causes you to use your body in different ways (for example, to limp or to sit differently), pain can develop in other areas of the body. Pain can also cause biochemical changes in your body that tend to keep the pain going. Without special treatment, you may get chronic pain syndrome.