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Report Abuse. When I have taken Vicodin...It would take about 20 minutes for it to kick-in....I know that depending on what dose you are taking and how bad your pain is can also effect how long it takes to kick-in... Chi Town Jaki Â· 8 years ago. Thumbs up.
Posts: 1,760. Kicks in at maybe 40 minutes for me, when swallowed. I usually dissolve them under my tongue though, so they kick in a lot more quickly. If you're wondering if they take days or even weeks like antidepressants do, then no, klonopin works pretty much instantly.