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Peak levels and half life of LSD. LSD has a plasma half-life of 2.5-4 hours. The onset of LSD effects is rapid following intravenous administration (10 minutes) and slower when taken orally (20-30 minutes). LSD effects usually peak at 2-4 hours and gradually diminishing over 6-8 hours. Residual effects may last longer but usually resolve within 12 hours of dosing.
Flashbacks and LSD. Some LSD users relive their experiences after the effects of the drug have worn off. Flashbacks are more common with regular users of acid, but it is possible for a person who has only tried it occasionally to have this experience.he LSD effect is described as a 'trip' because it is a long (8-12 hours) and powerful experience which takes you beyond normal perception and then back again.