Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
a bulging disc by itself rarely causes pain or other symptoms symptoms of a herniated disc discogenic pain due to tears and inflammation in a disc deep aching pain in the neck upper or lower back usually bilateral on both sides of the spine but not in the limbs 63