Agonists. Agonists bind to and activate receptors in a dose-dependent manner until all opioid receptors are occupied. At this point, the response plateau is reached, and increased doses of agonist have no effect. However, continued use beyond this plateau may lead to respiratory depression and overdose.ntagonists. Antagonists bind to the same receptors as full and partial agonists but do not cause activity at the receptor. Moreover, antagonists block agonists and partial agonists from binding and therefore prevent receptor activation altogether.
Tax Deductions for Voluntary Interest Payments on Student Loans. Most taxpayers who pay interest on student loans can take a tax deduction for the expense â and you can do this regardless of whether you itemize tax deductions on your return. The rules for claiming the deduction are the same whether the interest payments were required or voluntary.
The employee can deduct it as tax-deferred pay. Employer contributions are limited to the lesser of 25 percent of compensation or $50,000 for tax year 2012 and $51,000 for the 2013 tax year. An employee can deduct all SIMPLE contributions from taxable income, up to $11,500 in 2012, rising to $12,000 in 2013.An employee 50 or over can make catch-up contributions of $2,500 in 2012 and 2013 if the SIMPLE plan allows them.n employee can deduct all SIMPLE contributions from taxable income, up to $11,500 in 2012, rising to $12,000 in 2013. An employee 50 or over can make catch-up contributions of $2,500 in 2012 and 2013 if the SIMPLE plan allows them.