Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Back pain called sciatica is often caused by a compressed or irritated nerve root from a herniated disk in the spine. The shock-absorbing disks in your spinal cord experience wear and tear due to age, heavy lifting, improper posture, accidents or diabetes. Whatever the reason, it is painful.