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Deposition of calcium salts in the skin, subcutaneous tissue, or other part of the body in certain pathologic conditions. calcification, the deposit of calcium salts in tissues and organs that do not normally contain them in undissolved form.nterstitial calcinosis (calcium gout) is distinguished by the fact that there is no depletion of calcium in the bones and no excess concentration of calcium in the blood. The depositing of lime occurs in the skin and subcutaneous tissues or may spread to the muscles and other tissues.
Disseminated disease results after hematogenous spread, with the CNS and skin being the most common secondary sites. In addition to meningitis, disseminated Cryptococcus infection can cause hepatitis, osteomyelitis, prostatitis, pyelonephritis, and peritonitis. Cutaneous signs may be the first indication of infection, preceding the diagnosis of disseminated disease by 2-8 months, making its recognition crucial to early treatment.