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Most often, colon cancer spreads to the liver, but it can also spread to the ovaries, lungs, or brain. Colon cancer tends to spread to the liver first, because all of the blood from the colon drains to the liver before proceeding to the rest of the body.
This spread of cancer to a new part of the body is called metastasis. Cancer cells have to go through several steps to spread to new parts of the body: They have to be able to break away from the original tumor and enter the bloodstream or lymph system, which can carry them to another part of the body.