1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
The long-term negative effects of alcohol include cancer; 3.6% of all cancer cases worldwide are related to alcohol drinking, resulting in 3.5% of all cancer deaths. The more alcohol is consumed, the more negative effects of alcohol are seen. Negative effects of alcohol include: 1  Increased risk of heart failure. 2  Heart disease. 3  Anemia.