When it is preceded by a preposition it can be used instead of cui, e.g. il signore a cui hai telefonato ieri or il signore al quale hai telefonato ieri (the man who you phoned yesterday), but il quale, la quale is more formal and is used mainly in written rather than spoken Italian.
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1 The downvote of the popular website Reddit is identified as periwinkle, and one of the two teams of the site's April Fools event in 2013 was named for the color. Periwinkle blue is the color for esophageal and stomach cancer awareness ribbons, and for anorexia nervosa and bulimia. 2  It is also the color for pulmonary hypertension awareness ribbons.