Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Degenerative disc disease in the neck (the cervical spine) causes: 1  Decreased flexibility. 2  Neck pain. 3  Stiffness. 4  Pain radiating to the back of the shoulder or into the arms. 5  Numbness and tingling in the arms and hands. 6  Weakness. 7  Lower back and leg pain and weakness.