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Hyperglycemia does it by increasing the rate of transformation of NAD to NADH. Hypoxia makes it difficult for cells to turn NADH back to NAD. In both conditions the increased NADH is recycled back to NAD by processes that produce free radicals, chemically reactive compounds that can damage tissue. Williamson and his coauthors propose that long-term use of these processes causes the damage seen in diabetes.
Complications of diabetes include: 1  Heart Disease â People with diabetes have a higher risk for heart attack and stroke. 2  Eye Complications â People with diabetes have a higher risk of blindness and other vision problems. 3  Kidney Disease â Diabetes can damage the kidneys and may lead to kidney failure. Foot Problems â Nerve damage, infections of the feet, and problems with blood flow to the feet can be caused by diabetes. 2  Skin Complications â Diabetes can cause skin problems, such as infections, sores, and itching. 3  Skin problems are sometimes a first sign that someone has diabetes.