Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Sections. Neurogenic claudication is discomfort in the lower back or legs caused by nerve compression in the lumbosacral region of the spine. This is distinct from vascular claudication, which is caused by a circulatory problem within the lower back, buttocks or legs.Neurogenic means that the symptoms are related to a nerve, and claudication â which is Latin for âlimpâ â refers to cramping or weakness in the legs.his is distinct from vascular claudication, which is caused by a circulatory problem within the lower back, buttocks or legs. Neurogenic means that the symptoms are related to a nerve, and claudication â which is Latin for âlimpâ â refers to cramping or weakness in the legs.