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Report Abuse. When I have taken Vicodin...It would take about 20 minutes for it to kick-in....I know that depending on what dose you are taking and how bad your pain is can also effect how long it takes to kick-in... Chi Town Jaki Â· 8 years ago. Thumbs up.
3 May 2013. It takes 3 to 5 days for Vicodin to leave your body enough for you to have a clean Urine drug test! And you can NOT clear any drug, including vicodin from your system by drinking lots of water or anything else.