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Most often, colon cancer spreads to the liver, but it can also spread to the ovaries, lungs, or brain. Colon cancer tends to spread to the liver first, because all of the blood from the colon drains to the liver before proceeding to the rest of the body.
Liver cancer is the growth and spread of unhealthy cells in the liver. Cancer that starts in the liver is called primary liver cancer. Cancer that spreads to the liver from another organ is called metastatic liver cancer. About 30,000 Americans are diagnosed with primary liver cancer each year.