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Overview of Xylazine for Dogs and Cats. 1  Xylazine, commonly known as Rompun, belongs to a class of drugs known as alpha 2 adrenergic agonists and is similar to clonidine. 2  It is a sedative that provides pain relief as well as muscle relaxation to dogs.
Single Dose ToxicityAcute toxicity of xylazine has been investigated in laboratory animals. The proposed dose ranges for intramuscular and intravenous administration in dogs are 0.5-1 ml/10 kg bw (1-2 mg/kg bw) and 0.25-0.5 ml/10 kg bw (0.5-1 mg/kg bw), respectively.