You only need the English Proficient for international operations as it's an ICAO thing. Some countries, like France, check; others may not. Similar on the RRTO -- some countries, like Canada and the Bahamas don't require it, but others, like Turks & Caicos, do require it and do check it.
Apoptosis, or programmed cell death, is a naturally occurring process in the body. It involves a controlled sequence of steps in which cells signal self termination. Apoptosis works to keep the body's natural cell division process of mitosis in check.
Apoptosis also plays an essential role in morphogenesis and tissue homeostasis by eliminating transitory organs and tissues (for example, pronephros and mesonephros) and cells formed in excess of bodily needs during embryogenesis, as well as cells that have been damaged or virally infected.