Clinical Significance. Measurement of the levels of bilirubin is used in the diagnosis and treatment of liver, hemolytic, hematologic, and metabolic disorders, including hepatitis and gall bladder obstruction. The assessment of direct bilirubin is helpful in the differentiation of hepatic disorders.
Rhythm and Blues Music: Overview. and blues (R&B), which combines soulful singing and a strong backbeat, was the most popular music created by and for African Americans between the end of World War II (1941-45) and the early 1960s. Such Georgia artists as Ray Charles, Little Richard, and James Brown rank among the most influential and innovative R&B performers.
The immediate roots of rock and roll lay in the rhythm and blues, then called  race music , and country music of the 1940s and 1950s. Particularly significant influences were jazz, blues, gospel, country, and folk.