1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Long-term effects of aLcohoL use. Chronic heavy alcohol use can cause abnormalities. in the blood, leading to anaemia (low haemoglobin, the component of blood that carries oxygen around. the body) and low platelets (platelets help prevent. bleeding).[13] Chronic heavy alcohol use also suppresses.