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Great Saphenous Vein. This vein is a conjunction of the dorsal vein of the great toe and the dorsal venous arch of the foot. It travels up the leg, in front of the inner ankle protruberance (anterior to the medial malleolus), and ascends all the way up the lower limb on the inner aspect leg and thigh (anteromedial aspect).
Deep vein thrombosis, or DVT, a blood clot in a deep vein that develops after extended periods of inactivity, can also cause major leg pain. Long flights or car rides make it difficult for the leg to return blood back to the heart. If that blood return slows or stops, it can create a clot within the vein.