Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
People often assume that their back pain is caused by overdoing an activity, such as weight training, gardening, or work that requires a lot of digging, lifting or twisting. However, there are many causes of back pain. Fortunately, most causes are not as serious as a heart attack. Other causes include: Back muscle spasm, sprain or strain due to overuse or injury. Degenerative disc disease is a breakdown of your spinal discs that cushion your spine.