1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
(Redirected from Long-term effects of alcohol) The long-term effects of alcohol (ethanol) consumption range from cardioprotective health benefits for low to moderate alcohol consumption in industrialized societies with higher rates of cardiovascular disease to severe detrimental effects in cases of chronic alcohol abuse.