Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
The facets in the back of the spine can generate pain in the lower back. These structures generally are not typically the cause of as much lower back pain as the facets in the cervical spine are capable of generating neck pain. When the facets do cause pain, this pain mimics discogenic pain.