Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Cervical degenerative disc disease at a glance. 1  Neck pain can be caused by cervical (neck) disc degeneration. 2  The spinal discs act as shock absorbers between the vertebrae, allowing the spine and neck to bend and twist. Neck pain can be caused by cervical (neck) disc degeneration. 2  The spinal discs act as shock absorbers between the vertebrae, allowing the spine and neck to bend and twist. 3  A fall or injury can cause degeneration of the discs, but the most common cause is wear and tear over time.