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Most often, colon cancer spreads to the liver, but it can also spread to the ovaries, lungs, or brain. Colon cancer tends to spread to the liver first, because all of the blood from the colon drains to the liver before proceeding to the rest of the body.
Video: How cancer spreads. Cancer spreads â or metastasizes â when cancer cells break away from the original tumor and travel through your bloodstream or lymphatic system to other parts of your body. This video shows how a type of skin cancer called melanoma can metastasize.