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Peak levels and half life of LSD. LSD has a plasma half-life of 2.5-4 hours. The onset of LSD effects is rapid following intravenous administration (10 minutes) and slower when taken orally (20-30 minutes). LSD effects usually peak at 2-4 hours and gradually diminishing over 6-8 hours. Residual effects may last longer but usually resolve within 12 hours of dosing.
Report Share. I was told by psychiatrist when I got up to the dose of 225mg that it would take about 4 - 6 weeks to work. I was given the hard white slow release tablets. After 4 weeks I had a repeat prescription and the tablets were from Spain.