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Quick Answer. Liver nodules, usually a sign of liver disease, can be caused by certain parasitic or viral infections, immune system abnormalities, cancer and genetic conditions, according to Mayo Clinic. Contributing factors include heavy alcohol or drug use, unprotected sex, obesity, diabetes and exposure to certain chemicals.
Hepatocellular carcinoma is discussed elsewhere (see hepatocellular carcinoma). Non-malignant causes of liver nodules are increasingly diagnosed by imaging characteristics alone (i.e., simple cysts, hepatic adenomas, FNH, and hemangiomas). If liver abscess is suspected, aspiration should be pursued (see liver abscess).