Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Lumbar DDD Causes. The low back pain associated with lumbar degenerative disc disease is usually generated from one or both of two sources: 1  Inflammation, as the proteins in the disc space irritate the surrounding nerves-both the small nerve within the disc space and potentially the larger nerves that go to the legs.