Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Rather, the degeneration occurring in the spine is causing pain in the low back, and the degeneration process is causing the curve to form. A combination of the degeneration of the spine and scoliosis deformity may cause pressure on nerves and possibly even the entire spinal cord. This can lead to: weakness, numbness, and pain in the lower extremities.