Speciï¬cally, the sva package contains functions. for the identifying and building surrogate variables for. high-dimensional data sets. Surrogate variables are covariates. constructed directly from high-dimensional data (like gene. expression/RNA sequencing/methylation/brain imaging data) that. can be used in subsequent analyses to adjust for unknown, unmodeled, or latent sources of noise. The sva package can be.
Princess of Wales Diana Biography. Lady Diana Frances Spencer married Prince Charles (1948â) in 1981 and became Princess of Wales. Retaining her title and her popularity after the royal couple divorced in 1996, Diana continued her charitable work. She died in a tragic car accident in 1997.
It's no secret that Prince Charles and Princess Diana were never as perfect a match as they initially seemed, but a new claim that Charles was desperate to back out of the 1981 royal wedding makes the marriage seem like an especially bad idea in hindsight.