During the last decade, the efficacy of arsenic trioxide in both newly diagnosed and relapsed patients with APL 3 has been established. Arsenic trioxide can be used as a single agent and induces complete remissions with only minimal myelosuppression (1) (2, 3, 4, 5) . In one study (2) (1) .Additional studies conducted in the United States confirmed that low doses of arsenic trioxide can induce complete remission in relapsed APL patients.hite arsenic or arsenic trioxide (As 2 O 3) is produced by heating realgar (10) . Arsenic is rarely found in a pure state; rather, it exists in both trivalent and pentavalent oxidation states as a chemically unstable sulfide or oxide, or as a salt of sodium, potassium, or calcium (11) .
The most common statin side effects include: 1  Headache. 2  Difficulty sleeping. 3  Flushing of the skin.  Muscle aches, tenderness, or weakness 1  (myalgia) Drowsiness. 2  Dizziness. Nausea or vomiting.  Abdominal cramping 1  or pain. Bloating 2  or gas. 3  Diarrhea. Constipation.  Rash.
People have decidedly mixed feelings about the side effects associated with statins, according to a 2012 NPR-Truven Health Analytics poll. The worry, of course, is that the ranks of statin quitters include people at high risk of heart disease, for whom the daily dose of cholesterol-lowering drug can reduce the risk of deadly heart attacks.