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Peak levels and half life of LSD. LSD has a plasma half-life of 2.5-4 hours. The onset of LSD effects is rapid following intravenous administration (10 minutes) and slower when taken orally (20-30 minutes). LSD effects usually peak at 2-4 hours and gradually diminishing over 6-8 hours. Residual effects may last longer but usually resolve within 12 hours of dosing.
Long-Term Effects of LSD. LSD, or d-lysergic acid diethylamide, belongs to a class of drugs called hallucinogens. This synthetic drug was first produced in 1938 by Swiss scientist who was investigating the medical uses of a fungus that grows on various types of grass.n LSD episode, or trip, may last up to 12 hours or more. According to the Cleveland Clinic, the exact effect of LSD on the brain remains unknown, but the drug may affect your brainâs response to serotonin, a neurotransmitter that affects your emotions, moods and perceptions.