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Report Abuse. When I have taken Vicodin...It would take about 20 minutes for it to kick-in....I know that depending on what dose you are taking and how bad your pain is can also effect how long it takes to kick-in... Chi Town Jaki Â· 8 years ago. Thumbs up.
2 May 2013. It takes about a day to be out of your blood, and you can't count on it clearing your body totally that fast. It can help drinking water to get it out of your bladder, once it has cleared and gotten to your bladder. Meds all have half lives and you can't alter that. Vicodin is about 4 hrs.