ABSTRAL must be kept out of reach of children. [see Patient Counseling Information (17.1) and How Supplied/Storage and Handling (16.1)] The concomitant use of ABSTRAL with CYP3A4 inhibitors may result in an increase in fentanyl plasma concentrations, and may cause potentially fatal respiratory depression.
Renal osteodystrophy. Renal osteodystrophy or chronic kidney disease-mineral and bone disorder is a bone pathology, characterized by bone mineralization deficiency, that is a direct result of the electrolyte and endocrine derangements that accompany chronic kidney disease.
Kidney disease, also known as renal (or kidney) dysfunction, insufficiency, or failure, is a fairly common condition in dogs. The kidneys are hard-working organs that contribute to the normal function of many bodily processes, a few of which are: Removing waste from the body in the form of urine.