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Most often, colon cancer spreads to the liver, but it can also spread to the ovaries, lungs, or brain. Colon cancer tends to spread to the liver first, because all of the blood from the colon drains to the liver before proceeding to the rest of the body.
Colon cancer. Colon, or colorectal cancer, is cancer that starts in the large intestine (colon) or the rectum (end of the colon). Other types of cancer can affect the colon. These include lymphoma, carcinoid tumors, melanoma, and sarcomas. These are rare. In this article, colon cancer refers to colon carcinoma only.