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Report Abuse. When I have taken Vicodin...It would take about 20 minutes for it to kick-in....I know that depending on what dose you are taking and how bad your pain is can also effect how long it takes to kick-in... Chi Town Jaki Â· 8 years ago. Thumbs up.
They put me on vicodin 10/500mg (they had to up it a few times) for pain, and then as a preventative/when I start feeling strange/achy I take flexural 10mg (muscle relaxer really does help though). BUT the vicodin takes a long time to get into my system and the flexural is no help once Iâm in an attack.hich feels like extreme pain/pressure in the middle of my lower ribs/stomach area, that radiates to my middle slightly upper middle back or left shoulder blade area. She thought it sounded a lot like gallbladder issues and sent me to get an ultrasound of my GB.