Specific enzymes called hydroxylases are responsible for these important reactions needed to form hydroxyproline and hydroxylysine. The hydroxylase enzymes require Vitamin C and Iron as cofactors. If a patient is Vitamin C deficient, then this reaction will not occur.n the extracellular spaces, another post-translational modification takes place as the triple helical collagen molecules (Figure 1) line up and begin to form fibrils and then fibers. This step is called crosslink formation and is promoted by another specialized enzyme called lysyl oxidase (Figure 3).
Here's the original Moody Blues as nobody knows them: Denny Laine - guitar, vocals; Clint Warwick - bass guitar; Mike Pinder - keyboards, notably Mellotron; Ray Thomas - guitar, flute, different thingamajigs; Graeme Edge - drums, dumb bits of dumb poetry.
Ray Manzarek, who has died aged 74, was the keyboardist with The Doors, doing every bit as much to shape the bandâs dark, psychedelic sound as its charismatic, Dionysian lead singer, Jim Morrison. Manzarek did not try to compete with Morrisonâs astonishing good looks or Lizard King demeanour.