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Hyperglycemia does it by increasing the rate of transformation of NAD to NADH. Hypoxia makes it difficult for cells to turn NADH back to NAD. In both conditions the increased NADH is recycled back to NAD by processes that produce free radicals, chemically reactive compounds that can damage tissue. Williamson and his coauthors propose that long-term use of these processes causes the damage seen in diabetes.
Diabetes can affect the small blood vessels of the body that supply the skin with blood. Changes to the blood vessels because of diabetes can cause a skin condition called diabetic dermopathy. Dermopathy appears as scaly patches that are light brown or red, often on the front of the legs.The patches do not hurt, blister, or itch, and treatment generally is not necessary.any people with diabetes will have a skin disorder caused or affected by diabetes at some time in their lives. In some cases, skin problems can be the first sign that a person has diabetes. In some cases, people with diabetes develop skin conditions that can affect anyone.