1 Other symptoms may accompany the rash, such as joint pain, fever, chills, or fatigue. 2  If Lyme disease is not treated, more severe symptoms and complications can occur. 3  These include arthritis, neurologic symptoms, or heart problems.ymptoms. 1  A bull's-eye rash (erythema migrans) is the most definitive sign of Lyme disease infection. 2  Other symptoms may accompany the rash, such as joint pain, fever, chills, or fatigue. 3  If Lyme disease is not treated, more severe symptoms and complications can occur.
Dopamine production. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. It is a neurohormone that is released by the hypothalamus.
Dopamine Levels Increase. All addictive drugs affect brain pathways involving rewardâthat is, the dopamine system in the reward pathway. Within seconds to minutes of entering the body, drugs cause dramatic changes to synapses in the brain. By activating the brain's reward circuitry, drugs deliver a jolt of intense pleasure.