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Since the first therapeutic application of a r-protein produced in mammalian cells was approved in 1986. (human tissue plasminogen activator, tPA, Genentech), biopharmaceuticals have changed the. landscape for the treatment of many diseases, including many types of cancer, rheumatic conditions. and orphan diseases.
CRP is synthesized by the liver in response to factors released by macrophages and fat cells (adipocytes). It is a member of the pentraxin family of proteins. It is not related to C-peptide (insulin) or protein C (blood coagulation).C-reactive protein was the first pattern recognition receptor (PRR) to be identified.RP rises within two hours of the onset of inflammation, up to a 50,000-fold, and peaks at 48 hours. Its half-life of 18 hours is constant, and therefore its level is determined by the rate of production and hence the severity of the precipitating cause. CRP is thus a screen for inflammation.