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Nortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.ortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.
Alkylating agents Alkylating agents are most active in the resting phase of the cell. These types of drugs are cell-cycle non-specific. There are several types of alkylating agents used in chemotherapy treatments: 1  Mustard gas derivatives: Mechlorethamine, Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide. 2  Ethylenimines: Thiotepa and Hexamethylmelamine. 3  Alkylsulfonates: Busulfan.