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Peak levels and half life of LSD. LSD has a plasma half-life of 2.5-4 hours. The onset of LSD effects is rapid following intravenous administration (10 minutes) and slower when taken orally (20-30 minutes). LSD effects usually peak at 2-4 hours and gradually diminishing over 6-8 hours. Residual effects may last longer but usually resolve within 12 hours of dosing.
1 STEP ONE. 2  Be sure that you have set aside enough time in a comfortable setting. 3  LSD experiences last a long time. 4  You will need about 6-7 hours for a 100 ug dose and then there will be a gentle decline in intensity over a few hours.