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What could be causing my shortness of breath? Shortness of breath can be caused by many things, including the following: If you are short of breath with a cough and/or fever, you may have a chest infection or pneumonia (say: ânew-moan-yuhâ). Less common causes of breathing problems are lung cancer, a blood clot in the lungs,air leakage around the lungs and scarring of the lung tissue. 1  Asthma. 2  Other lung diseases, including emphysema (say: âem-fa-see-maâ), which is a lung disease that is most often caused by smoking. 3  Heart failure. 4  Panic attacks.
They have trouble getting air out of their lungs. Their air sacs where gas exchange takes place become damaged and lose elasticity, so it is hard for them to expel air out of their lungs and get rid of carbon dioxide (CO2). As a result, these people retain CO2 and tend to run low of oxygen. Their symptoms include shortness of breath, especially on exertion.