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What Is a Clinical Trial? A clinical trial is a research program conducted with patients to evaluate a new medical treatment, drug, or device. The purpose of clinical trials is to find new and improved methods of treating, preventing, screening for, and diagnosing different diseases.
Proof-of-Concept Clinical Trials. Signs of activity. Groundwork for definitive studies. Proof-of-concept clinical trials are carefully designed to establish the safety of drug candidates in the target population and explore the relationship between the dose and desired activity, as either measured directly or by means of a surrogate.