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Most often, colon cancer spreads to the liver, but it can also spread to the ovaries, lungs, or brain. Colon cancer tends to spread to the liver first, because all of the blood from the colon drains to the liver before proceeding to the rest of the body.
Colon cancer stages and symptoms. Colon cancer has four stages, with stage IV as the most severe stage because it means the cancer cells have spread (metastasized) to other organs like the liver (or lungs, lymph nodes, stomach or other organs).