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Peak levels and half life of LSD. LSD has a plasma half-life of 2.5-4 hours. The onset of LSD effects is rapid following intravenous administration (10 minutes) and slower when taken orally (20-30 minutes). LSD effects usually peak at 2-4 hours and gradually diminishing over 6-8 hours. Residual effects may last longer but usually resolve within 12 hours of dosing.
But note: 1  Methadone takes 2-4 hours to reach its peak effect level in the blood. However, the time it takes to produce its maximum effect can vary from person to person. 2  Methadone accumulates in your body. So, you will feel a greater effect of the drug over a few days even without increasing the dose.