Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Common Causes of Back Pain. 1  Whether your back pain is chronic or acute, it's possible to find some relief. 2  Weight. 3  Overweight people have an increased risk for back pain.  Sedentary 1  lifestyle. Lack of exercise can cause or worsen back pain because of increased stiffness and weakened muscles.  Sitting posture.