Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Chronic pain in the lower back may be caused by the discs or the joints of the spine. Lumbar Spine Anatomy Video. Learn how the lumbar spinal discs function and how lower back conditions can cause back pain and/or radiating pain.