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What could be causing my shortness of breath? Shortness of breath can be caused by many things, including the following: If you are short of breath with a cough and/or fever, you may have a chest infection or pneumonia (say: ânew-moan-yuhâ). Less common causes of breathing problems are lung cancer, a blood clot in the lungs,air leakage around the lungs and scarring of the lung tissue. 1  Asthma. 2  Other lung diseases, including emphysema (say: âem-fa-see-maâ), which is a lung disease that is most often caused by smoking. 3  Heart failure. 4  Panic attacks.
But even when shortness of breath is caused by a health condition, it can still lead to anxiety, because hyperventilation and trouble breathing can trigger anxiety attacks. When shortness of breath is caused by anxiety, you need to treat the anxiety first.