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Report Abuse. When I have taken Vicodin...It would take about 20 minutes for it to kick-in....I know that depending on what dose you are taking and how bad your pain is can also effect how long it takes to kick-in... Chi Town Jaki Â· 8 years ago. Thumbs up.
What do doctors prescribe Vicodin for? Vicodin narcotic analgesic is prescribed in inpatient and outpatient settings by medical doctors (MDs) in family practice or who specialize in pain management. Vicodin is a prescription drug used to manage mild to moderate pain. For pain relief, how long Vicodin lasts is about 4-6 hours.