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Peak levels and half life of LSD. LSD has a plasma half-life of 2.5-4 hours. The onset of LSD effects is rapid following intravenous administration (10 minutes) and slower when taken orally (20-30 minutes). LSD effects usually peak at 2-4 hours and gradually diminishing over 6-8 hours. Residual effects may last longer but usually resolve within 12 hours of dosing.
How soon does Vyvanse (lisdexamfetamine dimesylate) start working and how long does it last? In an adult clinical trial, Vyvanse was shown to start working 2 hours and 14 hours after taking the medication.