Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Back cramps can be painful and debilitating, and can be caused by a number of different things. Injury to the back, such as a pulled muscle, is one of the most common causes of back cramps. Poor posture, overexertion through exercise, improper lifting methods, or even menstrual cramps can all cause back pain as well, however, in addition to issues with the vertebrates of the spine. The most common cause of back cramps is physical injury.