Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Causes of Lower Back Pain. Pain in the lower back has a multitude of causes. The discs, facets, pars interarticularis, sacroiliac joints, hip joints and nerves can all cause a form of lower back pain. Even compression fractures at T12 and a high grade thoracic hyperkyphosis (increased thoracic curve) can cause lower back pain.