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Therapeutic vancomycin blood levels should be between 30 and 40 mg/l (maximum 50 mg/l) one hour after the end of the infusion, the minimum level (short prior to the next administration) between 5 and 10 mg/l. The concentrations should normally be monitored twice or three times per week.
One-half of the calculated fluid need is given in the first eight hours, and the remaining half is given over the subsequent 16 hours. The rate of infusion for IV resuscitation fluid should be as constant as possible; rapid declines in infusion rates can lead to vascular collapse and an increase in edema.