Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
Causes. Even though discogenic disease is not, by definition, a true disease, it still is a potentially life-altering condition. When the discs in your spine dry out, become brittle, bulge or become herniated, they can cause nerve pressure, which can result in pain, weakness, tingling, numbness and muscle weakness.