The thyroid hormones are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism. T3 and T4 are partially composed of iodine. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as simple goitre. The major form of thyroid hormone in the blood is thyroxine, which has a longer half-life than T3. In humans, the ratio of T4 to T3 released into the blood is sometimes c
As in the past, NIH requires the submission of an instructional plan addressing the responsible conduct of research. The November 24, 2009, notice NOT-OD-10-019 established a new expectation for the format of the training, subject matter, faculty participation, duration and frequency of instruction.
In 2016, the NIH added mortality and prevalence data from two sources of consistent and nationally-representative disease statistics provided by NCHS/CDC. These data are reported alongside the budgeting categories to provide the public and policymakers with information that is helpful for understanding the NIH research portfolio and its relationship to public health needs.