Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. At least a third of patients make an inadequate response to their first antidepressant monotherapy. Responses to subsequent courses are also limited.
Epidemiology/ Etiology. Discogenic pain is a form of low back pain, caused by chemically or mechanically damaged intervertebral discs.(level: 3A) This damage can find its origin in traumatic events, as well as in deterioration due to aging.
The pain of discogenic spondylosis. Discogenic spondylosis can occur in any region of the spine, and symptoms will vary accordingly. 1  Cervical spondylosis â occurs in the neck; pain may spread into the shoulders, down the arms and into the hands.