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You can do the math. Fentanyl lozenges-approx. 7 hours. Duragesic takes a few hours to kick in and is supposed to last up to 72 hours (like how Oxycontin is supposed to last 12 hours) but most people find it lasts 36-60 hours. From my experience I've found fentanyl patches to last about 48-54 hours.
Because Fentanyl is usually prescribed to patients already taking other opioid medications, the risk of overdose is greater. It is important to known how long Fentanyl remains in the system to avoid possible accidental overdose. The following are some of the symptoms of a Fentanyl overdose: 1  Slow, shallow breathing.  Decreased urge to breathe.