ABSTRAL must be kept out of reach of children. [see Patient Counseling Information (17.1) and How Supplied/Storage and Handling (16.1)] The concomitant use of ABSTRAL with CYP3A4 inhibitors may result in an increase in fentanyl plasma concentrations, and may cause potentially fatal respiratory depression.
Renal osteodystrophy. Renal osteodystrophy or chronic kidney disease-mineral and bone disorder is a bone pathology, characterized by bone mineralization deficiency, that is a direct result of the electrolyte and endocrine derangements that accompany chronic kidney disease.
Osteoarthritis. Definition. Osteoporosis is a bone disease. The word âosteoporosisâ literally means porous bones. It is a bone disorder characterized by decreased bone strength as a result of reduced bone quantity and quality.A person with osteoporosis has an increased risk of breaking a bone (fracturing) easily. Osteoporosis is a bone disease in which the amount and quality of the bone is reduced, leading to fractures (broken bones). 2  Osteoporosis produces no pain or other symptoms unless a fracture has occurred.