ABSTRAL must be kept out of reach of children. [see Patient Counseling Information (17.1) and How Supplied/Storage and Handling (16.1)] The concomitant use of ABSTRAL with CYP3A4 inhibitors may result in an increase in fentanyl plasma concentrations, and may cause potentially fatal respiratory depression.
Renal osteodystrophy. Renal osteodystrophy or chronic kidney disease-mineral and bone disorder is a bone pathology, characterized by bone mineralization deficiency, that is a direct result of the electrolyte and endocrine derangements that accompany chronic kidney disease.
Medical Definition of D.O. D.O.: Abbreviation for Doctor of Osteopathy, an osteopathic physician. Osteopathy is a system of therapy founded in the 19th century based on the concept that the body can formulate its own remedies against diseases when the body is in a normal structural relationship, has a normal environment and enjoys good nutrition.