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Sinus bradycardia can be the result of many things including good physical fitness, medications, and some forms of heart block. Sinus refers to the sinus node, the heart's natural pacemaker which creates the normal regular heartbeat.
Quick Answer. A malfunction in the sinus node in the heart may cause sinus bradycardia, according to the Heart Rhythm Society. The sinus node, located in the right atrium of the heart, may misfire, wear out or slow down over time, and these problems can lead to an abnormally slow heart rate. Slow heart rates generally go below 60 beats per minute.