Certain genes playing a key role in specification of pigment cell fates from the neural crest have been well characterized. At the core of melanocyte fate specification is the transcriptional activator microphthalmia-associated transcription factor (MITF; Mitfa in zebrafish).
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The main ingredient of soju is rice, almost always in combination with other ingredients such as wheat, barley, or sweet potatoes. Soju is clear-colored and typically varies in alcohol content from 10% to 25% proof. It was first known to have been distilled around 1300 A.D. Soju is the Korean equivalent of the Japanese sake. That said, Jinro is known to be the largest manufacturer of soju which recorded a sale of 70 million cases in 2004.