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Many of these diseases are genetic. Sometimes the cause is a medical condition such as alcoholism, a tumor, or a stroke. Other causes may include toxins, chemicals, and viruses. Sometimes the cause is not known. Degenerative nerve diseases include. 1  Alzheimer's disease. 2  Amyotrophic lateral sclerosis.
Degenerative muscle diseases cause progressive damage and loss of muscle cells with associated weakness. There are many types of degenerative muscle diseases, and they act in different ways to cause loss of functional muscle mass.