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An acute exacerbation of COPD is defined as increased shortness of breath, increased sputum production, a change in the color of the sputum from clear to green or yellow, or an increase in cough in someone with COPD.
Criteria for the diagnosis of COPD have been established.3 However, there is no validated diagnostic test or biomarker of COPD exacerbations.4 The American Thoracic Society (ATS) and European Respiratory Society (ERS) define an exacerbation as an acute change in a patient's baseline dyspnea, cough, or sputum that is beyond normal variability, and that is sufficient to warrant a change in therapy.5 The ATS and ERS classify COPD exacerbations as mild, moderate, or severe, based on the ...