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ANCA : Antineutrophil cytoplasmic antibodies (ANCA) can occur in patients with autoimmune vasculitis including Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), or organ-limited variants thereof such as pauci-immune necrotizing glomerulonephritis.(1) Detection of ANCA is a well-established diagnostic test for the evaluation of patients suspected of having autoimmune vasculitis.
Does a negative ANCA mean I don't have vasculitis? No, some patients can be ANCA positive and others ANCA negative. Individual patients may be positive at one blood test and negative at another. The physician uses the ANCA test as a guide to treatment, along with other test results and by examination and discussion with the patient. Hope that helps.