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A low RBC count indicates a decrease in oxygen-carrying cells in blood. The causes can be many, ranging from infections and deficiencies to malnutrition to malignancies, including: Anemia
What does a Low Red Blood Cell Count Indicate? A low red blood cell count that occurs during menstruation may not be a cause for concern. A low red blood cell count may indicate the presence of anemia. Most people learn they have a low red blood cell count through a routine CBC test. Individuals who have disorders that affect the number or function of red blood cells may experience fatigue.