The adjectives adverse and averse are related both etymologically and semantically, each having âoppositionâ as a central sense. Adverse is seldom used of people but rather of effects or events, and it usually conveys a sense of hostility or harmfulness: adverse reviews; adverse winds; adverse trends in the economy. Related nouns are adversity and adversary: Adversities breed bitterness. His adversaries countered his every move.
After oral administration, there is an early rise in serum concentration. Equilibration of serum and tissue levels occurs at approximately 6 to 8 hours. For this reason, blood specimens for digoxin analysis should be drawn at least 6 to 8 hours after drug administration. Digoxin is excreted primarily in the urine.
â¢ Blood should be taken 4 hours (3-5 hours) after a dose of Clexane for anti-Xa levels. â¢ For twice daily dosing, the therapeutic range is 0.6-1.0 IU/ml. â¢ For once daily dosing, the peak anti-Xa level should be 1-2 IU/ml (there is less literature on once daily dosing compared to twice daily dosing).