Collectively, these findings indicate that chronic repetitive ischemia that progresses to hibernating myocardium is associated with regional downregulation of the sarcoplasmic reticulum, with changes in calcium regulation and gene expression.onsidering the frequency of ischemia and the prevalence of hibernating myocardium, recognition of hibernation and how it affects treatment are important. The mortality rate is higher in patients with hibernating myocardium who do not undergo revascularization.
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