Caution should be used when administering Trazodone hydrochloride tablets to patients with cardiac disease and such patients should be closely monitored, since antidepressant drugs (including Trazodone hydrochloride) may cause cardiac arrhythmias.
1 Cook the brisket fat-side down at 325-375Â°F for 2 to 2-1/2 hours to an internal temperature of 170Â°F. 2  Wrap in foil fat-side up and cook another 2 to 2-1/2 hours until fork tender.3  Rest in foil for 30 minutes before slicing. Cook the brisket fat-side down at 325-375Â°F for 2 to 2-1/2 hours to an internal temperature of 170Â°F. 2  Wrap in foil fat-side up and cook another 2 to 2-1/2 hours until fork tender.
Get one in a Cryovac package. 2 Size of your brisket--a real good size is a brisket from 6 to 10 pounds. The size, big or small, will be more of a personal choice. Just remember slow cooking for 1 1/2 to 2 hours per pound is a pretty fair timetable for cooking a brisket at 225F. But first, ya got to season it! 3 Seasoning your brisket--there are as many ideas on the best way to season a brisket as there are brisket cooks.