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By comparison, people with Parkinsonâs disease typically experience a hand tremor when their muscles are at rest and see a reduction in the tremor when their muscles are in use. Shaky hands can also be caused by: 1  seizure. 2  overactive thyroid. 3  cerebellar disease. 4  Huntingtonâs disease.
Back to Top Causes. Cramps or spasms in the muscles often have no clear cause. Possible causes of hand or foot spasms include: 1  Brain disorders, such as parkinson's disease, multiple sclerosis, dystonia, and Huntington's disease. 2  Chronic kidney disease and dialysis. 3  Damage to a single nerve or nerve group (mononeuropathy) or multiple nerves (polyneuropathy) that are connected to muscles.