Caution should be used when administering Trazodone hydrochloride tablets to patients with cardiac disease and such patients should be closely monitored, since antidepressant drugs (including Trazodone hydrochloride) may cause cardiac arrhythmias.
1 Cook the brisket fat-side down at 325-375Â°F for 2 to 2-1/2 hours to an internal temperature of 170Â°F. 2  Wrap in foil fat-side up and cook another 2 to 2-1/2 hours until fork tender.3  Rest in foil for 30 minutes before slicing. Cook the brisket fat-side down at 325-375Â°F for 2 to 2-1/2 hours to an internal temperature of 170Â°F. 2  Wrap in foil fat-side up and cook another 2 to 2-1/2 hours until fork tender.
Bake the Brisket. 1  Place a fat-trimmed 3- to 3-1/2-pound fresh beef brisket in a 13x9x2-inch baking pan. 2  Pour the cooking liquid over the meat. 3  Cover the pan with foil. 4  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time. Season the brisket with ground black pepper. 2  Pour the sauce over the brisket. 3  Cover the slow cooker and cook on the low-heat setting for 12 to 14 hours. 4  Or cook on the high-heat setting for 6 to 7 hours.