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Subchondral bone marrow edema is also commonly seen in patients with degenerative joint disease (10 â 14). Subchondral bone marrow edema in patients with osteoarthritis of the knee joint has been associated with knee pain and the progression of articular cartilage degeneration (12, 13).
When someone has osteoarthritis, there is increased blood flow and other changes that develop in the subchondral layer. These include these processes that may cause osteoarthritis pain around the joint: Subchondral sclerosis: this is increased bone density and thickening of this layer.