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Subchondral bone marrow edema is also commonly seen in patients with degenerative joint disease (10 â 14). Subchondral bone marrow edema in patients with osteoarthritis of the knee joint has been associated with knee pain and the progression of articular cartilage degeneration (12, 13).
Subchondral cyst formation is characteristic of osteoarthritis and can be routinely found on x-rays. A subchondral cyst is a fluid-filled sac that extrudes from the joint, consisting of thickened joint material (mostly hyaluronic acid, a substance found in the normal joint fluid that serves to lubricate the joint). Subchondral bone is the layer of bone just below the cartilage.