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ANCA : Antineutrophil cytoplasmic antibodies (ANCA) can occur in patients with autoimmune vasculitis including Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), or organ-limited variants thereof such as pauci-immune necrotizing glomerulonephritis.(1) Detection of ANCA is a well-established diagnostic test for the evaluation of patients suspected of having autoimmune vasculitis.
Immunology of ANCA and ANCA-associated vasculitis (AAV) 1  Target of ANCA are proteins synthesized by neutrophils. 2  In EGPA/CSS, the target for the pathologic ANCA response is the neutrophil protein MPO while in GPA/WG, it's the neutrophil protein PR-3.