If a flexible screw is being used to convey the silica sand, it is important to use a screw that matches the silica sand's characteristics and other application requirements. Generally a screw with a round profile will be effective in moving a material with silica sand's features.
USES: Donepezil is used for the treatment of mild, moderate, or severe dementia associated with Alzheimer's disease. increased frequency of urination. stomach ulcers. MORE SERIOUS SIDE EFFECTS: Tacrine (Cognex), another anticholinesterase medication used in the treatment of Alzheimer's disease, is associated with liver toxicity.
Donepezil is both excreted in the urine intact and extensively metabolized to four major metabolites, two of. which are known to be active, and a number of minor metabolites, not all of which have been identified. Donepezil is metabolized by CYP 450 isoenzymes 2D6 and 3A4 and undergoes glucuronidation.