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Signs & Symptoms. ACTH deficiency can either be congenital or acquired, and its manifestations are clinically indistinguishable from those of glucocorticoid deficiency. Symptoms include weight loss, lack of appetite (anorexia), muscle weakness, nausea and vomiting, and low blood pressure (hypotension).
Symptoms of low bile production may include constipation, poor digestions, gas, excess acid, headaches, and gastric or acid reflux. These may also be signs of cholestasis, a condition where the excretion of bile is inhibited. Bile excretion can be inhibited when gallstones block the duct of the gall bladder.