Brigitta gives Dean a second, stronger dose of poison through her touch and tells him, That's for our father, implying that the djinn Sam and Dean killed in 2.20 was her father, and the other two djinn with her are her brothers.
COMMON MECHANISMS 47 adduct is formed, which has been used as a biomarker of effect (Albrecht and Neumann, 1985, Neumann, 2000, Sarkar et al. (2006). The use of Hb-adducts as biomarkers clearly demonstrates that the general population is exposed to many monocyclic and polycyclic aromatic amines (Bryant et al.owever, the models help to verify the proposed mode of action and in fact support it. In summary, a common mode of action is at the basis of the carcinogenic properties of aromatic amines and a carcinogenic potential seems to be associated with this whole group of chemicals.
The diol epoxide can exist in 4 stereoisomeric forms of which the key carcinogenic product is benzo(a)pyrene-r-7,t-8-diol-t-9,10-epoxide.â¢ PAH epoxides can then be conjugated with GSH. This conjugation is regarded as a true detoxification reaction and is mediated by glutathione transferase (GSTM1) .