Caution should be used when administering Trazodone hydrochloride tablets to patients with cardiac disease and such patients should be closely monitored, since antidepressant drugs (including Trazodone hydrochloride) may cause cardiac arrhythmias.
1 Cook the brisket fat-side down at 325-375Â°F for 2 to 2-1/2 hours to an internal temperature of 170Â°F. 2  Wrap in foil fat-side up and cook another 2 to 2-1/2 hours until fork tender.3  Rest in foil for 30 minutes before slicing. Cook the brisket fat-side down at 325-375Â°F for 2 to 2-1/2 hours to an internal temperature of 170Â°F. 2  Wrap in foil fat-side up and cook another 2 to 2-1/2 hours until fork tender.
How long per pound to cook a brisket in the oven? At 275-300 degrees preferably. Also any tips on how to prepare would be helpful also please. I asked my grandmother how to make it, she actually makes brisket quite often, yet she could not tell me how she makes it. Quite hilarious, but not quite helpful. Anyhow, thanks for your input.