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Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with varicella zoster virus (VZV).The disease results in a characteristic skin rash that forms small, itchy blisters, which eventually scab over.hickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with varicella zoster virus (VZV).
What Is the Chickenpox Vaccine? The chickenpox vaccine is a shot that can protect nearly anyone who receives the vaccine from catching chickenpox. It's also called the varicella vaccine, because chickenpox is caused by the varicella-zoster virus. The vaccine is made from a live but weakened, or attenuated, virus. Viruses that have been attenuated are less virulent than viruses that are not.