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By comparison, people with Parkinsonâs disease typically experience a hand tremor when their muscles are at rest and see a reduction in the tremor when their muscles are in use. Shaky hands can also be caused by: 1  seizure. 2  overactive thyroid. 3  cerebellar disease. 4  Huntingtonâs disease.
Although the cause of cold hands can be as simple as being in a cold environment or your body's natural response to maintain its normal temperature, if you have ongoing problems with cold hands, there could be a number of causes. Having cold hands could signal a problem with your blood circulation or the blood vessels in your hands. Causes of cold hands include: Anemia. Buerger's disease. Diabetes. Frostbite. Lupus. Raynaud's disease.