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Though Zofran was originally created in 1984 to treat nausea and vomiting in cancer patients after receiving chemotherapy, the drug is most commonly used today by pregnant women. It metabolizes in the liver and has a shelf-life of five to seven hours. Common side effects of the drug are headaches and sometimes constipation.
Read More. I had the same exact problem. I had to get a prescription for zofran, but also some things that helped were pedialyte Popsicles, and don't eat to get full, you have to eat like a bird, like take one bite of a cracker and wait take a little sip of water, wait etc.