Dremel 543 and EZ544 are both carbide cutting wheels for cutting and shaping on woods, fiberglass, plastics and laminates. Do not use them on metals. For 543 the mandrel is included; for EZ544 use the EZ402 Mandrel.
After Domagk published his findings in 1935, doctors found that Prontosil could control many bacterial infections. Subsequently, other researchers developed derivatives based on the Prontosil sulfonamide group. The resulting so-called sulfa drugs revolutionized medicine and saved many thousands of lives.
Structural similarity between sulfonamide (left) and PABA (center) is the basis for the inhibitory activity of sulfa drugs on dihydrofolate (right) biosynthesis. A Sulfonamide (or sulphonamide) is a kind of drug. It is a man-made antibiotic. Their ability to kill infectious bacteria is their main function, but some types have other medical uses. For example, sulfasalazine, in addition to its use as an antibiotic, is also used in the treatment of inflammatory bowel disease. Sulfonamides (sometimes called sulfa drugs or sulpha drugs) contain the sulfonamide chemical group.