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Signs & Symptoms. ACTH deficiency can either be congenital or acquired, and its manifestations are clinically indistinguishable from those of glucocorticoid deficiency. Symptoms include weight loss, lack of appetite (anorexia), muscle weakness, nausea and vomiting, and low blood pressure (hypotension).
If blood sodium levels are low due to insufficient intake, then urine concentrations will also be low. 1  Decreased urinary sodium levels may indicate dehydration, congestive heart failure, liver disease, or nephrotic syndrome. 2  Increased urinary sodium levels may indicate diuretic use or Addison disease.