Where, as above, C is annuity payment, PV is principal, n is number of payments, starting at end of first period, and i is interest rate per period. Equivalently C is the periodic loan repayment for a loan of PV extending over n periods at interest rate, i.
Refractory epilepsy is a seizure disorder that resists drug treatment. There is some debate among clinicians and researchers about how to define refractory epilepsy. As a result, this term is used in a variety of ways, and when a patient's epilepsy is described as refractory, resistant, or nonresponsive, it can be advisable to ask for more detail about what the diagnosis means.
This first study will take place at 5 sites, with 25 patients at each site, all with epilepsy refractory to current treatment. Most of the participants will be children with Dravet syndrome, but there will also be some children with other severe forms of epilepsy and some young adults.