[ 2 syll. hol-den, ho-ld-en ] The baby boy name Holden is sometimes used as a girl name. Its pronunciation is HH OW L-DehN â . Holden is used predominantly in the English language and it is derived from Old English origins.The name's meaning is deep valley, hollow in the valley.It is derived from the elements 'holh' meaning hollow, hole; 'denu' valley.olden is popular as a baby name for boys, and it is also considered trendy. The name's popularity has been rising since the 1980s; before that, it was of very modest use only. At the recent peak of its usage in 2012, 0.058% of baby boys were given the name Holden.
In fish, birds and other non-mammalian animals, calcitonin is produced by cells of the ultimobranchial body. Calcitonin opposes the effects of parathyroid hormone (PTH), which acts to increase the blood calcium level. Calcitonin lowers blood calcium levels by suppressing osteoclast activity in the bones and increasing the amount of calcium excreted in the urine. The hormone also prevents the absorption of calcium from the intestine, as well as increasing the calcium absorbed by the kidney. However, the production and increased activity of calcitonin is only short-lived and many patients with chronic hypercalcemia (raised blood calcium) do not have high blood calcitonin levels.
Human or salmon calcitonin has no significant effects on blood pressure (18) but salmon calcitonin induces negative chronotropic and negative inotropic effects on isolated dog atrium (19), suggesting that it has a possible role in the regulation of myocardial contractile force and rate.