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A spliceosome is a large and complex molecular machine found primarily within the splicing speckles of the cell nucleus of eukaryotic cells. The spliceosome is assembled from snRNAs and protein complexes. The spliceosome removes introns from a transcribed pre-mRNA, a kind of primary transcript.This process is generally referred to as splicing.he RNA component of the small nuclear ribonucleic protein or snRNP (pronounced snurp) is rich in uridine (the nucleoside analog of the uracil nucleotide). The canonical assembly of the spliceosome occurs anew on each hnRNA (pre-mRNA).
Most splicing occurs between exons on a single RNA transcript, but occasionally trans-splicing occurs, in which exons on different pre-mRNAs are ligated together. The splicing process occurs in cellular machines called spliceosomes, in which the snRNPs are found along with additional proteins.igure 1: Pre-mRNA splicing. Splicing of a pre-mRNA molecule occurs in several steps that are catalyzed by small nuclear ribonucleoproteins (snRNPs). After the U1 snRNP binds to the 5â² splice site, the 5â² end of the intron base pairs with the downstream branch sequence, forming a lariat.