When this specific three-dimensional structure is disrupted, the protein loses its functionality and is said to have undergone denaturation. The interactions, such as hydrogen bonding , that dictate the tertiary structure of proteins are not as strong as covalent chemical bonds.
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In sociology, the tipping point is the moment when something unique in society becomes commonplace. Also known as the angle of repose. The phrase was coined by political scientist Morton Grodzins. A book was written (and published in 2000) on such dramatic moments by Malcolm Gladwell. Also, the title of (the Philladelphia hip-hop group) the Roots' 2004 album.