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Signs & Symptoms. ACTH deficiency can either be congenital or acquired, and its manifestations are clinically indistinguishable from those of glucocorticoid deficiency. Symptoms include weight loss, lack of appetite (anorexia), muscle weakness, nausea and vomiting, and low blood pressure (hypotension).
*Characterized by high aldosterone and low renin levels *Renin levels are low due to negative feedback -Adrenal cortex producing high levels of aldosterone has an inhibitory effect on the kidney's production of renin Aldosterone: Hypersecretion Symptoms *Hypernatremia (high sodium)