These discussions ultimately led to the development of certain regulations and guidelines, which evolved into the code of practice by which all those involved in clinical research now work. This code is known as International Conference on Harmonisation of Good Clinical Practice
A signing statement is a written pronouncement issued by the President of the United States upon the signing of a bill into law. They are usually printed along with the bill in United States Code Congressional and Administrative News (USCCAN).
However, there is also no part of the Constitution that grants legal value to signing statements. Article I, Section 7 (in the Presentment Clause) empowers the president to veto a law in its entirety, to sign it, or to do nothing.