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ACTH is made in the pituitary gland in response to the release of another hormone, called corticotropin-releasing hormone (CRH), by the hypothalamus. In turn, the adrenal glands then make a hormone called cortisol, which helps your body manage stress. A problem with the adrenal glands or pituitary gland. 2  A high level of ACTH and a low level of cortisol (or low ACTH and high cortisol levels) could be caused by a problem with the adrenal glands. 3  Low levels of ACTH and cortisol could be caused by a problem with the pituitary gland. 4  Overproduction of ACTH.
ACTH. n. Adrenocorticotropic hormone; a hormone that is produced by the anterior lobe of the pituitary gland and that stimulates the secretion of cortisone, aldosterone, and other hormones by the adrenal cortex.Also called adrenocorticotropin, adrenotropin, corticotropin.CTH. adrenocorticotropic hormone; produced by the anterior lobe of the pituitary gland that stimulates the cortex of the adrenal gland to secrete its hormones, including corticosterone. If production of ACTH falls below normal, the adrenal cortex decreases in size, and production of the cortical hormones declines.