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Signs & Symptoms. ACTH deficiency can either be congenital or acquired, and its manifestations are clinically indistinguishable from those of glucocorticoid deficiency. Symptoms include weight loss, lack of appetite (anorexia), muscle weakness, nausea and vomiting, and low blood pressure (hypotension).
These blood tests can reveal a number of telling symptoms that point to low cortisol, such as an increased level of potassium, a low level of sodium, and rarely, a high level of calcium. When checked for low cortisol levels, it is best to be tested for other adrenal hormone deficiencies, such as aldosterone and ACTH.