Morphine, like many prescription drugs, may require larger doses for pain control when used for extended periods of time. Over time, the body can develop a tolerance for the medication and will require more medication to experience the same level of effectiveness.
By Kimberly Munro Fri, Mar 18, 2011. The first installment of our Ancient Peru series relates what archaeology has revealed about its first cities and civilizations. The expansive, culturally rich civilizations that existed in the Americas at the time of European contact came as a great surprise to the early Spanish explorers. Most notable were the Aztec empire in Central Mexico and the Incan empire in Peru, both of which controlled great expanses of land and millions of people.
The earliest human artifacts in Mexico are chips of stone tools found near campfire remains in the Valley of Mexico and radiocarbon-dated to circa 10,000 years ago. Mexico is the site of the domestication of maize, tomato and beans, which produced an agricultural surplus.