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The two sides of the plasma membrane have different lipid and protein composition. EXPLANATION: Because the membrane serves different functions on the cytoplasmic and exterior surfaces, the structure and composition of the surfaces must be different. 2 Which of the following best describes the structure of a biological membrane? two layers of phospholipids with proteins either crossing the layers or on the surface of the layers explanation:
The Fluid Mosaic Model [edit]. The fluid mosaic model was originally proposed by S. Jonathan Singer and Garth Nicolson in 1972. Their idea of this model was to show and describe the general structure of a biological membrane.Biological membrane is composed of a lipid bilayer  that is essentially a two-dimensional solution composed of lipids and proteins.o break down each part of the name of the model: The fluidity of the model is based on the hydrophobic components like proteins and lipids. These two components allow for the membrane to have a fluid motion since it is not solid; it is not made of only one type of macromolecule.