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CREST syndrome: Introduction. CREST syndrome is a type of systemic scleroderma and an ongoing, progressive, autoimmune disease that attacks the connective tissues of the body. CREST syndrome can also affect any part of the body.CREST is an acronym for a group of conditions that are hallmarks of CREST syndrome and affect the skin, muscles, digestive tract and other organs and blood vessels. The exact cause of CREST syndrome is not known, but it is classified as an autoimmune disease.REST is an acronym for a group of conditions that are hallmarks of CREST syndrome and affect the skin, muscles, digestive tract and other organs and blood vessels. The exact cause of CREST syndrome is not known, but it is classified as an autoimmune disease.
Background. CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome is a member of the heterogeneous group of sclerodermas, and its name is an acronym for the cardinal clinical features of the syndrome.n 1910, Thibierge and Weissenbach described the first case report of what was later called CRST (calcinosis cutis, Raynaud phenomenon, sclerodactyly, and telangiectasia) syndrome in English by Winterbauer who, in 1964, described a series of 8 patients with the features that make up the abbreviation CRST.