Philosophy â A definition: Philosophy. Philosophy is the discipline concerned with questions of how one should live (ethics); what sorts of things exist and what are their essential natures (metaphysics); what counts as genuine knowledge (epistemology); and what are the correct principles of reasoning (logic).hilosophy is the discipline concerned with questions of how one should live (ethics); what sorts of things exist and what are their essential natures (metaphysics); what counts as genuine knowledge (epistemology); and what are the correct principles of reasoning (logic).
Agonists are chemical substances that mimic or enhance the effects of neurotransmitters on the receptor sites of the next cell. If the neurotransmitter was excitatory, the effect of the agonist would be to increase the inhibitory. the agonist blockst the inhibitory effect.Antagonist drugs are chemical substances that block or reduce a cell's response to the action of other neurotransmitters.If the neurotransmitter is inhibitory, the antagonist would increase the activity of the cell.ntagonist drugs are chemical substances that block or reduce a cell's response to the action of other neurotransmitters. If the neurotransmitter is inhibitory, the antagonist would increase the activity of the cell.
A prerequisite for an inverse agonist response is that the receptor must have a constitutive (also known as intrinsic or basal) level activity in the absence of any ligand. An agonist increases the activity of a receptor above its basal level, whereas an inverse agonist decreases the activity below the basal level.A neutral antagonist has no activity in the absence of an agonist or inverse agonist but can block the activity of either.The efficacy.n agonist increases the activity of a receptor above its basal level, whereas an inverse agonist decreases the activity below the basal level. A neutral antagonist has no activity in the absence of an agonist or inverse agonist but can block the activity of either. The efficacy.