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Many of these diseases are genetic. Sometimes the cause is a medical condition such as alcoholism, a tumor, or a stroke. Other causes may include toxins, chemicals, and viruses. Sometimes the cause is not known. Degenerative nerve diseases include. 1  Alzheimer's disease. 2  Amyotrophic lateral sclerosis.
: a disease (as arteriosclerosis, diabetes mellitus, or osteoarthritis) characterized by progressive degenerative changes in tissue.2 ENTRIES FOUND: 1  degenerative disease (noun). a disease (as arteriosclerosis, diabetes mellitus, or osteoarthritis) characterized by progressive degenerative changes in tissue. 2 ENTRIES FOUND: 1  degenerative disease (noun).