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Signs & Symptoms. ACTH deficiency can either be congenital or acquired, and its manifestations are clinically indistinguishable from those of glucocorticoid deficiency. Symptoms include weight loss, lack of appetite (anorexia), muscle weakness, nausea and vomiting, and low blood pressure (hypotension).
Lower-than-normal levels of ACTH may be seen with: 1  Pituitary gland that is not producing enough hormones, such as ACTH. 2  Tumor of the adrenal gland that produces too much cortisol. 3  Tumor elsewhere in the body that produces cortisol.