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Though Zofran was originally created in 1984 to treat nausea and vomiting in cancer patients after receiving chemotherapy, the drug is most commonly used today by pregnant women. It metabolizes in the liver and has a shelf-life of five to seven hours. Common side effects of the drug are headaches and sometimes constipation.
What is Zofran? Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation). Zofran is not for preventing nausea or vomiting that is caused by factors other than cancer treatment or surgery. You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).