Caution should be used when administering Trazodone hydrochloride tablets to patients with cardiac disease and such patients should be closely monitored, since antidepressant drugs (including Trazodone hydrochloride) may cause cardiac arrhythmias.
1 Cook the brisket fat-side down at 325-375Â°F for 2 to 2-1/2 hours to an internal temperature of 170Â°F. 2  Wrap in foil fat-side up and cook another 2 to 2-1/2 hours until fork tender.3  Rest in foil for 30 minutes before slicing. Cook the brisket fat-side down at 325-375Â°F for 2 to 2-1/2 hours to an internal temperature of 170Â°F. 2  Wrap in foil fat-side up and cook another 2 to 2-1/2 hours until fork tender.
Estimated Cooking Time. How long will it take to cook brisket to 200-205 F? As a rough estimate, assuming a cooker temp of 225-250Â°F, figure 1 hour to 1 hour 30 minutes per pound for a whole, packer brisket weighing 12 pounds after trimming any excess fat.hole, untrimmed briskets weigh 8-20 pounds. A brisket about 12 pounds fits easily on either WSM cooking grate. Briskets larger than 12 pounds can be shoehorned between the handles on the cooking grate and will shrink during cooking.