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By comparison, people with Parkinsonâs disease typically experience a hand tremor when their muscles are at rest and see a reduction in the tremor when their muscles are in use. Shaky hands can also be caused by: 1  seizure. 2  overactive thyroid. 3  cerebellar disease. 4  Huntingtonâs disease.
Other causes of numb hands may include: 1  Nutritional deficiencies, such as vitamin B1 deficiency. 2  Multiple sclerosis. 3  Stroke. 4  Disorders of the brain and spinal cord.