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  The difference is that a 2wd car will only have two of the four wheels supplied with power to drive, either front wheel drive or rear wheel drive. A car with 4wd will â¦ have power supplied to all four wheels, giving it better driving abilities in wet or slick conditions.wd = four wheel drive. awd = all wheel drive. These two are the same thing. It is a system where all four wheels of the car are connected to the engine and is very good on vehicles used where you need more traction than usual.
Best Answer: The main difference between these vehicles is that the GS is larger and slightly more powerful this year as Lexus replaced the GS300 with the GS350. Thew new GS makes 303 hp. The ES is all about comfort and luxury.It's FWD (Front wheel drive) whereas the GS is RWD (Rear Wheel Drive).Performance enthusiasts will prefer RWD, but most drivers won't see any difference between FWD and RWD cars. The ES offers as many features as the GS and is about 5k cheaper.he ES is all about comfort and luxury. It's FWD (Front wheel drive) whereas the GS is RWD (Rear Wheel Drive). Performance enthusiasts will prefer RWD, but most drivers won't see any difference between FWD and RWD cars. The ES offers as many features as the GS and is about 5k cheaper.