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Answers. Best Answer: usually i think when they say the venom is non-lethal they mean the venom itself is non-lethal not the fact that it's only non-lethal to humans. so a wolf spider can't kill a dog from strictly venom.
Yet, occasionally, a spider's bites will cause real harm. Spider bites may cause injury by three mechanisms. First, especially with larger spiders, the bite itself may be painful and cause injury. However, far more concerning is the spider's venom, which can include necrotic agents or neurotoxins.