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Definition. 1  Cardiomyopathy is a chronic disease of the heart muscle (myocardium), in which the muscle is abnormally enlarged, thickened, and/or stiffened. The weakened heart muscle loses the ability to pump blood effectively, resulting in irregular heartbeats (arrhythmias) and possibly even heart failure.
A. A. A. Cardiomyopathy, or heart muscle disease, is a type of progressive heart disease in which the heart is abnormally enlarged, thickened, and/or stiffened. As a result, the heart muscle's ability to pump blood is weakened, often causing heart failure and the backup of blood into the lungs or rest of the body.The disease can also cause abnormal heart rhythms.t's the news you don't want to hear from your cardiologist: One or more of your coronary arteries -- the blood vessels that supply blood to your heart -- is blocked. You have coronary artery disease, the No. 1 killer of U.S. adults.