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Peeling skin can occur as a reaction to a number of inflammatory processes of the skin or damage to the skin. Sunburn is a classic example, but other conditions that can cause peeling skin include various forms of dermatitis, eczema, and certain infections. Burns of any degree of severity can result in peeling skin. Some types of medications, such as topical retinoids used for acne, can cause peeling skin. Adverse reactions to medications such as cancer chemotherapeutic agents can also lead to peeling skin. Any condition that results in the formation of a blister can result in peeling skin at the area of the blister.
Acral peeling skin syndrome is caused by mutations in the TGM5 gene. This gene provides instructions for making an enzyme called transglutaminase 5, which is a component of the outer layer of skin (the epidermis).kin peeling is made worse by exposure to heat, humidity and other forms of moisture, and friction. The underlying skin may be temporarily red and itchy, but it typically heals without scarring. Acral peeling skin syndrome is not associated with any other health problems.