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Definition. 1  Cardiomyopathy is a chronic disease of the heart muscle (myocardium), in which the muscle is abnormally enlarged, thickened, and/or stiffened. The weakened heart muscle loses the ability to pump blood effectively, resulting in irregular heartbeats (arrhythmias) and possibly even heart failure.
Hypertrophic cardiomyopathy is a primary disease of the heart muscle (myocardium) characterised by hypertrophy (an increase in the thickness) of the left ventricle, associated with an overactive left ventricle and a small left ventricular chamber.ypertrophic Cardiomyopathy. Hypertrophic cardiomyopathy is a disease of the heart muscle. It can cause sudden death, particularly in young, active men. Medicines can prevent a fatal outcome. Further research is being carried out in the search for better treatments.