These discussions ultimately led to the development of certain regulations and guidelines, which evolved into the code of practice by which all those involved in clinical research now work. This code is known as International Conference on Harmonisation of Good Clinical Practice
A signing statement is a written pronouncement issued by the President of the United States upon the signing of a bill into law. They are usually printed along with the bill in United States Code Congressional and Administrative News (USCCAN).
The non-signing statement is a related method that some presidents have used to express concerns about certain provisions in a bill without vetoing it. With the non-signing statement, presidents announce their reasons for declining to sign, while allowing the bill to become law unsigned.