The adjectives adverse and averse are related both etymologically and semantically, each having âoppositionâ as a central sense. Adverse is seldom used of people but rather of effects or events, and it usually conveys a sense of hostility or harmfulness: adverse reviews; adverse winds; adverse trends in the economy. Related nouns are adversity and adversary: Adversities breed bitterness. His adversaries countered his every move.
After oral administration, there is an early rise in serum concentration. Equilibration of serum and tissue levels occurs at approximately 6 to 8 hours. For this reason, blood specimens for digoxin analysis should be drawn at least 6 to 8 hours after drug administration. Digoxin is excreted primarily in the urine.
Heart Failure. As per ACCF/AHA guidelines, a loading dose to initiate digoxin therapy in patients with heart failure is not necessary. 0.125-0.25 mg PO/IV qDay; higher doses including 0.375-0.5 mg/day rarely needed. Use lower end of dosing (0.125 mg/day) in patients with impaired renal function or low lean body mass.aintenance. 1  PO: 3.4-5.1 mcg/kg/day or 0.125-0.5 mg/day PO; may increase dose every 2 weeks based on clinical response, serum drug levels, and toxicity. 2  IV/IM: 0.1-0.4 mg qDay; IM route not preferred due to severe injection site reaction.