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The maximum dose for domperidone is 20 mg 4 times per day. The suggested beginning dose is 10 mg 4 times per day for 1 week, then increasing to 20 mg 4 times per day. This should be increased gradually as per the instructions in the individual protocols.
It is not usually considered advisable to take anti-inflammatory medication in pregnancy, which makes SPD a particularly difficult condition to manage. Women are therefore typically often prescribed 30 mg or 60 mg of codeine phosphate to be taken in conjunction with 1,000 mg paracetamol, four times a day.