Long-term muscle use requires the delivery of oxygen and glucose to the muscle fiber to allow aerobic respiration to occur, producing the ATP required for muscle contraction. If the respiratory or circulatory system cannot keep up with demand, then energy will be generated by the much less efficient anaerobic respiration.
Then, Nicaragua, as well as Costa Rica, El Salvador, Guatemala and Honduras formed the United Provinces of Central America, but that federation quickly dissolved, and Nicaragua became an independent republic in 1838.
Explore the stunning city of Leon. Situated in western Nicaragua, Leon is the second most important city after Managua. Blessed with graceful old architecture and a fascinating history, Leon has played a pivotal role in the country's history many times over.