DEA 3.0 System: Dogs may have a DEA 3 system of blood type, if their blood has two antigens, DEA 3.0 and DEA Null. This is a rare type of blood and occurs in only in 5 â 6% of dogs. The most common breed with a DEA 3.0 positive type blood are grey hounds, in which 23% of all population is considered positive. If the dog is incompatible for this blood type and is transfused, erythrocytes or blood cells are usually replaced in 3 â 5 days, automatically.
Executive Summary. 1  The bloodâbrain barrier (BBB) is a significant obstacle to therapeutic delivery for CNS disorders. Among various strategies, nanobiotechnology plays an important role in facilitating drug delivery across the BBB. 2  Desirable characteristics of the ideal method of therapeutic delivery across the BBB are described in this article.
The bloodâbrain barrier regulates brain extracellular fluid. Brain capillaries form a tight barrier except in specialised areas. Tight junctions restrict paracellular movement of substances across the bloodâbrain barrier. Astrocytes contribute to differentiation of the bloodâbrain barrier.Transport across the bloodâbrain barrier may be passive or active.rain capillaries form a tight barrier except in specialised areas. Tight junctions restrict paracellular movement of substances across the bloodâbrain barrier. Astrocytes contribute to differentiation of the bloodâbrain barrier. Transport across the bloodâbrain barrier may be passive or active.