When the site of metastasis is a single organ (such as the liver), and the cancer is confined to a single defined area within the organ, patients may benefit from local treatment directed at that single metastasis. The majority of patients diagnosed with Stage IV colon cancer have unresectable or widespread disease.
Mileage. It's common for bikers to overestimate their annual mileage and moped riders are no exception, but stating more miles than you'll actually cover can cost you when it comes to insurance premiums. Although most bikers average around 3,000 miles a year, on a 50cc scooter your mileage could well be a lot lower.
Average Cost of Motorcycle Insurance. We performed a study in all 50 states to see what the average motorcycle insurance quotes was in each one. We then took the aggregate of those premiums and found that the average annual motorcycle insurance rate in the U.S. was $519. The District of Columbia was not included in our study.