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Caffeine works by stimulating the central nervous system (CNS), heart, muscles, and the centers that control blood pressure. Caffeine can raise blood pressure, but might not have this effect in people who use it all the time. Caffeine can also act like a âwater pillâ that increases urine flow.
Medications and supplements that can raise your blood pressure From pain medications to stimulants, know which drugs and supplements can affect your blood pressure. By Mayo Clinic Staff Some prescription and over-the-counter medications, as well as supplements and other substances, can raise your blood pressure. These substances also can interfere with medications intended to lower your blood pressure. Here are some medications, supplements and other substances that can increase your blood pressure. If you're using any of these substances and are worried about the effect it could have on your blood pressure, talk to your doctor.