Commercial Off-The-Shelf (COTS) Definition - What does Commercial Off-The-Shelf (COTS) mean? Commercial off-the-shelf (COTS) is a term that references non-developmental items (NDI) sold in the commercial marketplace and used or obtained through government contracts. The set of rules for COTS is defined by the Federal Acquisition Regulation (FAR).
Acromegaly is usually caused by a non-cancerous tumor in the pituitary gland called a pituitary adenoma. The tumor produces too much GH and raises the level of GH in the blood. Too much GH also raises the level of insulin-like growth factor-1 (IGF-1), a hormone produced in the liver that also promotes growth. Rarely, acromegaly is caused by hormone-producing tumors in other parts of the body.
acromegaly. abnormal enlargement of the extremities of the skeleton due to overgrowth of connective tissue and increased appositional growth of bone caused by hypersecretion of growth hormone (GH) from the pituitary gland in adults. (Marie's disease), a condition caused by hyperfunction of the pituitary gland in adults. Characterized by enlargement of the skeletal extremities, including the feet, hands, mandible, and nose. Acromegaly.