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Wiktionary (0.00 / 0 votes) Rate this definition: septum (Noun). A wall separating two cavities; a partition; as, the nasal septum. septum (Noun). A partition that separates the cells of a fruit. septum (Noun).
Nasal septum: The dividing wall that runs down the middle of the nose, separating the two nasal ' cavities, each of which ends in a nostril. The nasal septum is composed of bone, cartilage, and 'membranes.