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The duodenum is the first part of the small intestine. It is located between the stomach and the middle part of the small intestine, or jejunum. After foods mix with stomach acid, they move into the duodenum, where they mix with bile from the gallbladder and digestive juices from the pancreas.
A duodenal ulcer is a type of peptic ulcer that occurs in the duodenum, the beginning of the small intestine. Peptic ulcers are eroded areas in the lining of stomach and duodenum, which result in abdominal pain, possible bleeding, and other gastrointestinal symptoms.he most common cause of duodenal ulcer is a stomach infection associated with the Helicobacter pylori (H pylori) bacteria. Other risk factors for duodenal ulcers include overuse of alcohol, tobacco, and medications such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).