RESULTS: In 6 patients, the mirtazapine doses ranged from 10 to 30 times the maximum recommended dose, and there were no serious adverse effects of overdose.Two patients at special risk, a 90-year-old man and a 3-year-old child, took higher-than-usual doses without serious sequelae.ONCLUSION: After an overdose of substantial multiples of mirtazapine that exceed the maximum recommended daily dosage, the new antidepressant mirtazapine appears to be safe in a limited number of cases.
The drugs that are approved to reduce the pain of diabetic peripheral neuropathy are expensive. But your doctor can prescribe much less costly drugs that might save you thousands of dollars and may work equally well. No drugs do anything more than cut the pain. To reverse the neuropathy, you have to act. A pair of articles that the American College of Physicians published in its November 4 issue of the Annals of Internal Medicine compares our choices and recommends our options.
Narcotics may also cause side effects that could make symptoms of autonomic neuropathy worse. So narcotics are not often the first type of medicine tried for symptoms of diabetic neuropathy. If you begin taking an antidepressant or an anticonvulsant medicine for pain, it may take several weeks to see whether it is working.