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Wiktionary (0.00 / 0 votes) Rate this definition: septum (Noun). A wall separating two cavities; a partition; as, the nasal septum. septum (Noun). A partition that separates the cells of a fruit. septum (Noun).
Understanding A Deviated Septum. The septum is a thin barrier that is made up of cartilage that separates the two nostrils. Generally the septum is thought to be located midway between the two areas, dividing them equally. A deviated septum occurs when this partition is off-center, shifting prominently to one side.