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Angelman syndrome is a genetic disorder that affects the nervous system and causes severe physical and intellectual disability. It's relatively rare, occurring in around 1 in 16,000 people.Typical characteristics of Angelman syndrome include: 1  delayed development (usually noticeable from 6-12 months of age).n most cases of Angelman syndrome (about 70%), the child's maternal copy of the UBE3A gene is missing, which means there's no active copy of the UBE3A gene in the child's brain.
It is the same part of chromosome 15 that is usually affected in people with Angelman syndrome, although different genes are associated with the two disorders. People can have either Prader-Willi syndrome or Angelman syndrome, but they typically cannot have both. People normally inherit one copy of chromosome 15 from each parent. Some genes on this chromosome are turned on (active) only on the copy inherited from a person's father (the paternal copy).