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Background: Suicide is a leading cause of death in patients with bipolar disorder. Risk factors and prevention of suicide in this. illness are the focus of considerable current research. Methods: MEDLINE data base was searched for the key words âbipolar disorderâ with âsuicideâ, lithium with suicide,
Causes. The exact cause of bipolar disorder is unknown, but several factors may be involved, such as: 1  Biological differences. 2  People with bipolar disorder appear to have physical changes in their brains. 3  The significance of these changes is still uncertain but may eventually help pinpoint causes.4  Neurotransmitters.he exact cause of bipolar disorder is unknown, but several factors may be involved, such as: 1  Biological differences. 2  Neurotransmitters. 3  Inherited traits. 4  Symptoms. 5  Risk factors.