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Bipolar disorder patients die prematurely from a wide range of causes, from heart disease to the flu, a Swedish population study showed. MedpageToday. Action Points. Note that this large Swedish registry study demonstrated a markedly increased risk of mortality among sufferers of bipolar disorder.
Causes. The exact cause of bipolar disorder is unknown, but several factors may be involved, such as: 1  Biological differences. 2  People with bipolar disorder appear to have physical changes in their brains. 3  The significance of these changes is still uncertain but may eventually help pinpoint causes.4  Neurotransmitters.he exact cause of bipolar disorder is unknown, but several factors may be involved, such as: 1  Biological differences. 2  Neurotransmitters. 3  Inherited traits. 4  Symptoms. 5  Risk factors.