The Causes of Discolored Toenails. Discolored toe nails may be white, yellow, brown, green, or even black and all of these discolorations may be caused by a nail fungus infection of varying stages.
(evolocumab) for Subcutaneous Injection. Evolocumab is a human monoclonal immunoglobulin G2 (IgG2) directed against human proprotein convertase subtilisin kexin 9 (PCSK9). Evolocumab has an approximate molecular weight (MW) of 144 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells. REPATHA is a sterile, preservative-free, clear to opalescent, colorless to pale yellow solution for subcutaneous administration. Each 1 mL single-use prefilled syringe and single-use prefilled SureClickÂ® autoinjector contains 140 mg evolocumab, acetate (1.2 mg), polysorbate 80 (0.1 mg), proline (25 mg) in Water for Injection, USP.
Amgenâs experimental Repatha drug lowers cholesterol by 60 percent, according to FDA reviewers. The injectable drug is one of a new class of drugs considered the first major advance in lowering bad cholesterol in 20 years.hile Amgen will not discuss pricing plans for Repatha â and the FDA is barred from considering cost when reviewing drugs â Express Scripts and other companies are already raising concerns about the impact on health care budgets.