Long-term muscle use requires the delivery of oxygen and glucose to the muscle fiber to allow aerobic respiration to occur, producing the ATP required for muscle contraction. If the respiratory or circulatory system cannot keep up with demand, then energy will be generated by the much less efficient anaerobic respiration.
Then, Nicaragua, as well as Costa Rica, El Salvador, Guatemala and Honduras formed the United Provinces of Central America, but that federation quickly dissolved, and Nicaragua became an independent republic in 1838.
Masaya is the capital city of Masaya department in Nicaragua. It is situated approximately 14 km west of Granada and 31 km southeast from Managua. The town of Masaya is just east of Masaya Volcano, an active volcano from which the city takes its name. With an estimated population of 140,000, it is Nicaragua's third most populous city, and it is culturally known as the City of Flowers.