DEA 3.0 System: Dogs may have a DEA 3 system of blood type, if their blood has two antigens, DEA 3.0 and DEA Null. This is a rare type of blood and occurs in only in 5 â 6% of dogs. The most common breed with a DEA 3.0 positive type blood are grey hounds, in which 23% of all population is considered positive. If the dog is incompatible for this blood type and is transfused, erythrocytes or blood cells are usually replaced in 3 â 5 days, automatically.
Executive Summary. 1  The bloodâbrain barrier (BBB) is a significant obstacle to therapeutic delivery for CNS disorders. Among various strategies, nanobiotechnology plays an important role in facilitating drug delivery across the BBB. 2  Desirable characteristics of the ideal method of therapeutic delivery across the BBB are described in this article.
Key Concepts: 1  The bloodâbrain barrier regulates brain extracellular fluid. 2  Brain capillaries form a tight barrier except in specialised areas. 3  Tight junctions restrict paracellular movement of substances across the bloodâbrain barrier. 4  Astrocytes contribute to differentiation of the bloodâbrain barrier.