Vincristine is occasionally used as an immunosuppressant, for example, in treating thrombotic thrombocytopenic purpura (TTP) or chronic idiopathic thrombocytopenic purpura (ITP). Side effects. The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine.
Bonuses can be taxed in two ways: Percentage Method. The percentage method taxes a bonus at a flat rate, normally 25%. If the bonus is in excess of $1 million, it is taxed at a rate of 39.6%. This means that if your bonus is $10,000, and you are taxed using the percentage method, $2,500 goes to the IRS. This method is easy to calculate for both employee and employer because the bonus is taxed at a flat rate.
Using the previous example, the gross amount of the bonus, accounting for federal and state taxes due, is $14,492.75 ($10,000 / .69). Step 4. Subtract the gross amount that you owe the employee from the agreed-upon bonus to determine the gross-up federal and state tax amount.Using the previous example, the gross-up amount for federal and state income taxes is $4,492.75 ($14,492.75 - $10,000).ubtract the total tax percentage from 100 percent to determine the net tax percentage. For example, assume that your employee must pay 31 percent on a $10,000 bonus. The net tax percentage is 69 percent (100 - 31).