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Background: Suicide is a leading cause of death in patients with bipolar disorder. Risk factors and prevention of suicide in this. illness are the focus of considerable current research. Methods: MEDLINE data base was searched for the key words âbipolar disorderâ with âsuicideâ, lithium with suicide,
Environmental Factors in Bipolar Disorder. 1  A life event may trigger a mood episode in a person with a genetic disposition for bipolar disorder. 2  Even without clear genetic factors, altered health habits, alcohol or drug abuse, or hormonal problems can trigger an episode.