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Angelman syndrome is a genetic disorder that affects the nervous system and causes severe physical and intellectual disability. It's relatively rare, occurring in around 1 in 16,000 people.Typical characteristics of Angelman syndrome include: 1  delayed development (usually noticeable from 6-12 months of age).n most cases of Angelman syndrome (about 70%), the child's maternal copy of the UBE3A gene is missing, which means there's no active copy of the UBE3A gene in the child's brain.
Prevelance statistics about Angelman syndrome: The following statistics relate to the prevalence of Angelman syndrome: Angelman Syndrome affects all races and sexes equally in the US (Dr Harry Angelman, Angelman Syndrome Foundation) There are 1000 to 5000 cases of Angelman Syndrome in the US and Canada (Dr Harry Angelman, Angelman Syndrome Foundation)