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Translation: Taking expired doxycycline can harm your kidneys. While it is true that some drugs merely lose strength after their expiration date, many drugs (especially antibiotics!!) break down into harmful chemical products, similar to the way juice or wine can ferment if left too long. Bottom line--don't take them.
Quick Answer. Although an antibiotic's half-life equals half the time it takes to leave an individual's system, it takes five half-lives for the drug to clear a person's system completely, according to HealthTap. Each drug has its own specific half-life, so different antibiotics remain in the system for different lengths of time. Keep Learning.