Even if we stopped all carbon dioxide emissions tomorrow, we'd still see some effects, Haq says. That, of course, is the bad news. But there's also good news. By aggressively reducing our global emissions now, we can avoid a lot of the severe consequences that climate change would otherwise bring, says Haq.
Lipophilicity is possibly the lost important physicochemical property of a potential drug, it plays a role in solubility, absorption, membrane penetration, plasma protein binding, distribution, CNS penetration and partitioning into other tissues or organs such as the liver and has an impact on the routes of clearance.owever the majority of known drugs contain ionisable groups and are likely to be charged at physiological pH and LogP only correctly describes the partition coefficient of neutral (uncharged) molecules. LogD the distribution constant is a better descriptor of the lipophilicity of a molecule.
Abstract. 1  Drugs with narrow therapeutic index (NTI-drugs) are drugs with small differences between therapeutic and toxic doses. The pattern of drug-related problems (DRPs) associated with these drugs has not been explored. To investigate how, and to what extent drugs, with a narrow therapeutic index (NTI-drugs), as compared with other drugs, relate to different types of drug-related problems (DRPs) in hospitalised patients.