Fast Facts. 1  Granulomatosis with polyangiitis (Wegener's) â GPA â is serious but treatable. 2  The cause of GPA is unknown. 3  GPA often affects the sinuses, lungs and kidneys, and can lead to kidney failure.  Recurrences of this form of vasculitis are common.
Warfarin is the oral anticoagulant most frequently used to control and prevent thromboembolic disorders. Prescribing the dose that both avoids hemorrhagic complications and achieves sufficient suppression of thrombosis requires a thorough understanding of the drug's unique pharmacology.
To help warfarin (Coumadin) work effectively, it is important to keep your vitamin K intake as consistent as possible. Sudden increases in vitamin K intake may decrease the effect of warfarin (Coumadin). On the other hand, greatly lowering your vitamin K intake could increase the effect of warfarin (Coumadin).