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Antidepressants are medications used to treat depression and several other disorders. With proper treatment, often including antidepressants, 70% - 80% of people with major depressive disorder (MDD) can achieve a significant reduction in symptoms.1.ricyclic antidepressants drugs have been used to treat depression since the 1950s. This type of depression medication acts on neurotransmitters like serotonin and other chemicals as well. Tricyclics include drugs like: 1  Amitriptyline (Elavil, Levate). 2  Amoxapine (Asendin). 3  Clomipramine (Anafranil).
Antidepressants, particularly the selective serotonin reuptake inhibitors (SSRIs), are widely used to treat and prevent a variety of anxiety disorders. Examples of SSRIs that are commonly used to treat chronic anxiety include citalopram , escitalopram , fluoxetine , paroxetine , and sertraline . The antidepressants duloxetine and venlafaxine , SNRIs (serotonin and norepinephrine reuptake inhibitors) which act on the brain chemicals serotonin and norephinephrine, and some of the tricyclic antidepressants like imipramine , may also help.