The terms âdrug allergy,â âdrug hypersensitivity,â and âdrug reactionâ are often used interchangeably. Drug reactions encompass all adverse events related to drug administration, regardless of etiology.Drug hypersensitivity is defined as an immune-mediated response to a drug agent in a sensitized patient.dverse drug reactions caused by immune and nonimmune mechanisms are a major cause of morbidity and mortality worldwide. They are the most common iatrogenic illness, complicating 5 to 15 percent of therapeutic drug courses.
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