Normally, the Classic period in Mesoamerica is characterized as the stage in which the arts, science, urbanism, architecture, and social organization reached their peak. This period was also dominated by the influence of Teotihuacan throughout the region, and the competition between the different Mesoamerican states led to continuous warfare.
The most common name for the killer virus, the Spanish flu, implied, of course, that it originated in Spain. Perhaps this was because there were serious outbreaks in both Madrid and Seville that infected eight million people in May of 1918 alone, even almost taking out the king himself, Alfonso XIII.
The 1918 flu, or Spanish flu, caused the highest number of known influenza deaths. More than 500,000 people died in the United States, and up to 50 million people may have died worldwide. Many people died within the first few days after infection with the Spanish flu, and others died of related complications.