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Bipolar disorder patients die prematurely from a wide range of causes, from heart disease to the flu, a Swedish population study showed. MedpageToday. Action Points. Note that this large Swedish registry study demonstrated a markedly increased risk of mortality among sufferers of bipolar disorder.
Biochemical Changes May Cause Bipolar Disorder. In trying to uncover the causes of bipolar disorder, scientists have used brain imaging scans and other tests. 1  an over-secretion of cortisol, a stress hormone.  a super-fast biological clock that may disrupt the sleep-wake cycle.