Long-term muscle use requires the delivery of oxygen and glucose to the muscle fiber to allow aerobic respiration to occur, producing the ATP required for muscle contraction. If the respiratory or circulatory system cannot keep up with demand, then energy will be generated by the much less efficient anaerobic respiration.
Then, Nicaragua, as well as Costa Rica, El Salvador, Guatemala and Honduras formed the United Provinces of Central America, but that federation quickly dissolved, and Nicaragua became an independent republic in 1838.
Zapatera is a shield volcano located in the southern part of Nicaragua. It forms the island of Isla Zapatera in the Lake Nicaragua. Isla Zapatera constitutes one of 78 protected areas of Nicaragua. As of 1850, Zapatera was described uninhabited by British writer John Baily.