Even if we stopped all carbon dioxide emissions tomorrow, we'd still see some effects, Haq says. That, of course, is the bad news. But there's also good news. By aggressively reducing our global emissions now, we can avoid a lot of the severe consequences that climate change would otherwise bring, says Haq.
Lipophilicity is possibly the lost important physicochemical property of a potential drug, it plays a role in solubility, absorption, membrane penetration, plasma protein binding, distribution, CNS penetration and partitioning into other tissues or organs such as the liver and has an impact on the routes of clearance.owever the majority of known drugs contain ionisable groups and are likely to be charged at physiological pH and LogP only correctly describes the partition coefficient of neutral (uncharged) molecules. LogD the distribution constant is a better descriptor of the lipophilicity of a molecule.
The use of lipophilic drugs or derivatives has also been shown to be useful in providing protection against hydrolytic decomposition of the drugs. A water soluble drug, when present in the aqueous compartment of liposomes, apart from its tendency to rapidly leach out, is also prone to hydrolytic attack.he synthesis of lipophilic prodrugs is the other approach that has been tried as a solution to the problem of low entrapment of 6-MP. Mueller (mÃ¼ller) 1988 synthesised-(6)octadecyldithio (Purine. fig) 9 by linking the drug to A c 18 thiol through a disulfide. bond