Prostate cancer may cause no signs or symptoms in its early stages. Prostate cancer that is more advanced may cause signs and symptoms such as: 1  Trouble urinating. 2  Decreased force in the stream of urine. 3  Blood in the semen. 4  Discomfort in the pelvic area. 5  Bone pain. 6  Erectile dysfunction.
Letrozole is like clomid but works in a different way, therefore even if clomid did not work for you letrozole could. The only thing to keep in mind is that it does cause birth defects IF taken when your are ALREADY pregnant so be sure your doc checks you out thoroughly via ultrasound before taking this drug.
âAn issue not addressed is the use of palbociclib with fulvestrant after it has already been given as a first-line treatment in combination with letrozole. Based on the PALOMA1 data, and the accelerated FDA approval, many patients will likely receive palbociclib and letrozole in the first-line setting.