Long-term muscle use requires the delivery of oxygen and glucose to the muscle fiber to allow aerobic respiration to occur, producing the ATP required for muscle contraction. If the respiratory or circulatory system cannot keep up with demand, then energy will be generated by the much less efficient anaerobic respiration.
Then, Nicaragua, as well as Costa Rica, El Salvador, Guatemala and Honduras formed the United Provinces of Central America, but that federation quickly dissolved, and Nicaragua became an independent republic in 1838.
Managua is situated about 45 km (about 28 mi) from the Pacific Ocean, on the southern shore of Lake Managua. It lies in the western lowlands, Nicaragua s most densely populated region, between the major cities of Le n and Granada.