The Causes of Discolored Toenails. Discolored toe nails may be white, yellow, brown, green, or even black and all of these discolorations may be caused by a nail fungus infection of varying stages.
(evolocumab) for Subcutaneous Injection. Evolocumab is a human monoclonal immunoglobulin G2 (IgG2) directed against human proprotein convertase subtilisin kexin 9 (PCSK9). Evolocumab has an approximate molecular weight (MW) of 144 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells. REPATHA is a sterile, preservative-free, clear to opalescent, colorless to pale yellow solution for subcutaneous administration. Each 1 mL single-use prefilled syringe and single-use prefilled SureClickÂ® autoinjector contains 140 mg evolocumab, acetate (1.2 mg), polysorbate 80 (0.1 mg), proline (25 mg) in Water for Injection, USP.
It expects to spend $750 million on the drugs in 2016, which is far below the $20 billion in total national spending that some industry analysts had estimated, a spokesman for Express Scripts said. Praluent and Repatha are PCSK9 inhibitors, a new class of treatments that dramatically lower LDL cholesterol levels.The new therapies are expensiveâthe wholesale acquisition cost, excluding discounts, for Praluent is $14,600 per year. Repatha costs slightly less, about $14,100.raluent and Repatha are PCSK9 inhibitors, a new class of treatments that dramatically lower LDL cholesterol levels. The new therapies are expensiveâthe wholesale acquisition cost, excluding discounts, for Praluent is $14,600 per year.