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Angelman syndrome is a genetic disorder that affects the nervous system and causes severe physical and intellectual disability. It's relatively rare, occurring in around 1 in 16,000 people.Typical characteristics of Angelman syndrome include: 1  delayed development (usually noticeable from 6-12 months of age).n most cases of Angelman syndrome (about 70%), the child's maternal copy of the UBE3A gene is missing, which means there's no active copy of the UBE3A gene in the child's brain.
Angelman syndrome signs and symptoms include: 1  Developmental delays, including no crawling or babbling at 6 to 12 months. 2  Intellectual disability. 3  No speech or minimal speech. 4  Difficulty walking, moving or balancing well (ataxia) 5  Frequent smiling and laughter. 6  Happy, excitable personality.