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Caffeine works by stimulating the central nervous system (CNS), heart, muscles, and the centers that control blood pressure. Caffeine can raise blood pressure, but might not have this effect in people who use it all the time. Caffeine can also act like a âwater pillâ that increases urine flow.
This narrowing can affect other blood vessels as well, which can increase blood pressure. To keep your blood pressure in check, avoid over-the-counter decongestants and multisymptom cold remedies that contain decongestants â such as pseudoephedrine, ephedrine, phenylephrine, naphazoline and oxymetazoline. Instead: 1  Choose a cold medication designed for people who have high blood pressure.