Employees are entitled to their final paycheck, in due time. Comstock/Comstock/Getty Images. An expired payroll check can create a financial accounting problem for any company. Companies may have to account for expired checks because employees fail to pick them up or fail to cash the check. Employers have various options for dealing with a final or stale paycheck, but once the check expires it creates additional work for the payroll department.
allele frequency. The allele frequency represents the incidence of a gene variant in a population. Alleles are variant forms of a gene that are located at the same position, or genetic locus, on a chromosome.
For the following discussion: Variant allele frequency = read count supporting mutant base / total read count at that position For heterozygous somatic variants we can expect a tumor variant allele frequency of 50% and a normal variant allele frequency of 0%.Of course there will always be some variability due to some of the technical artifacts already discussed (random sequencing errors, etc.).n this case somatic variants that exist only in the sub-clone will have a substantially reduced tumor variant allele frequency. When both purity and heterogeneity are in play, interpreting tumor variant allele frequencies just gets more and more complicated ...