Vincristine is occasionally used as an immunosuppressant, for example, in treating thrombotic thrombocytopenic purpura (TTP) or chronic idiopathic thrombocytopenic purpura (ITP). Side effects. The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine.
Bonuses can be taxed in two ways: Percentage Method. The percentage method taxes a bonus at a flat rate, normally 25%. If the bonus is in excess of $1 million, it is taxed at a rate of 39.6%. This means that if your bonus is $10,000, and you are taxed using the percentage method, $2,500 goes to the IRS. This method is easy to calculate for both employee and employer because the bonus is taxed at a flat rate.
Basically, under IRS rules, companies have three options in calculating taxes on bonuses. The first two listed immediately below apply where the bonus is paid to you separately from your regular pay. The third is applicable when the employer gives you your bonus and regular pay in one payment.ere your employer adds the amount of your bonus to the amount of your most recent regular paycheck. Letâs say that your regular gross paycheck is $2000, and your bonus is $5000, for a combined total of $7000. Letâs also assume that the normal withholding from your regular pay is $500.