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Wiktionary (0.00 / 0 votes) Rate this definition: septum (Noun). A wall separating two cavities; a partition; as, the nasal septum. septum (Noun). A partition that separates the cells of a fruit. septum (Noun).
In this article. A deviated septum is a condition in which the nasal septum -- the bone and cartilage that divide the nasal cavity of the nose in half -- is significantly off center, or crooked, making breathing difficult. Most people have some sort of imbalance in the size of their breathing passages.