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The maximum dose for domperidone is 20 mg 4 times per day. The suggested beginning dose is 10 mg 4 times per day for 1 week, then increasing to 20 mg 4 times per day. This should be increased gradually as per the instructions in the individual protocols.
At that time, a slow steroid taper is initiated if the initial prednisone dosage was 15 or 20 mg per day. The approach varies but generally involves decreasing the dosage by 1 to 2.5 mg per day every four weeks. 4 Symptom recurrences are common and should be treated with a return to the initial dosage.