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Wiktionary (0.00 / 0 votes) Rate this definition: septum (Noun). A wall separating two cavities; a partition; as, the nasal septum. septum (Noun). A partition that separates the cells of a fruit. septum (Noun).
Interatrial septum, the wall of tissue that is a sectional part of the left and right atria of the heart; Interventricular septum, the wall separating the left and right ventricles of the heart; Lingual septum, a vertical layer of fibrous tissue that separates the halves of the tongue; Nasal septum: the cartilage wall separating the nostrils of the nose