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Angelman syndrome is a genetic disorder that affects the nervous system and causes severe physical and intellectual disability. It's relatively rare, occurring in around 1 in 16,000 people.Typical characteristics of Angelman syndrome include: 1  delayed development (usually noticeable from 6-12 months of age).n most cases of Angelman syndrome (about 70%), the child's maternal copy of the UBE3A gene is missing, which means there's no active copy of the UBE3A gene in the child's brain.
1 Angelman syndrome is a genetic disorder with characteristic features that include severe speech impairment, developmental delay, intellectual disability, and ataxia (problems with movement and balance). 2  Angelman syndrome is named after the physician Harry Angelman who first delineated the syndrome in 1965.ngelman syndrome facts*. *Angelman syndrome facts medically edited by: Melissa Conrad Stoeppler. 1  StÃ¶ppler angelman syndrome is a genetic disorder with characteristic features that include severe speech, impairment developmental, delay intellectual, disability and (ataxia problems with movement and).  balance