The insertion and origin of a muscle are the two places where it is anchored, one at each end. The tissue of the attachment is called an enthesis. The origin of a muscle is the bone, typically proximal, which has greater mass and is more stable during a contraction than a muscle's insertion.
Alendronate is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Cholecalciferol is a form of vitamin D, and is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Alendronate and cholecalciferol is used to treat and prevent osteoporosis. Alendronate and cholecalciferol may also be used for purposes not listed in this medication guide. You should not take this medicine if you have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus.
So talk with your doctor about how to reduce your risk of side effects. Most studies of alendronate and the other osteoporosis medications have involved postmenopausal women with osteoporosis, so it's not clear how well they work for men or younger women. This report was published in September 2013. Low calcium levels in your blood (can be reversed by taking calcium supplements). 2  Possible increased risk of breaking a thigh bone if taking these medications for five years or longer. 3  Bone, joint, or muscle pain.