Commercial Off-The-Shelf (COTS) Definition - What does Commercial Off-The-Shelf (COTS) mean? Commercial off-the-shelf (COTS) is a term that references non-developmental items (NDI) sold in the commercial marketplace and used or obtained through government contracts. The set of rules for COTS is defined by the Federal Acquisition Regulation (FAR).
Acromegaly is usually caused by a non-cancerous tumor in the pituitary gland called a pituitary adenoma. The tumor produces too much GH and raises the level of GH in the blood. Too much GH also raises the level of insulin-like growth factor-1 (IGF-1), a hormone produced in the liver that also promotes growth. Rarely, acromegaly is caused by hormone-producing tumors in other parts of the body.
Glioblastomas (GBM) are tumors that arise from astrocytesâthe star-shaped cells that make up the âglue-like,â or supportive tissue of the brain. These tumors are usually highly malignant (cancerous) because the cells reproduce quickly and they are supported by a large network of blood vessels. Location.lioblastomas (GBM) are tumors that arise from astrocytesâthe star-shaped cells that make up the âglue-like,â or supportive tissue of the brain. These tumors are usually highly malignant (cancerous) because the cells reproduce quickly and they are supported by a large network of blood vessels. Location.