Vincristine is occasionally used as an immunosuppressant, for example, in treating thrombotic thrombocytopenic purpura (TTP) or chronic idiopathic thrombocytopenic purpura (ITP). Side effects. The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine.
Bonuses can be taxed in two ways: Percentage Method. The percentage method taxes a bonus at a flat rate, normally 25%. If the bonus is in excess of $1 million, it is taxed at a rate of 39.6%. This means that if your bonus is $10,000, and you are taxed using the percentage method, $2,500 goes to the IRS. This method is easy to calculate for both employee and employer because the bonus is taxed at a flat rate.
Online calculators are good if you earn the same amount every month but can be difficult to use when earnings vary. However, unless you've missed out something that would make your situation unusual, you won't pay any tax at 40%, only 22%, and the NI will be 11% on Â£586.50 of the bonus and 1% on the remainder.Therefore, if your gross bonus is Â£2,317.50, it will be worth Â£1,725 after tax and NI.owever, unless you've missed out something that would make your situation unusual, you won't pay any tax at 40%, only 22%, and the NI will be 11% on Â£586.50 of the bonus and 1% on the remainder. Therefore, if your gross bonus is Â£2,317.50, it will be worth Â£1,725 after tax and NI.