Usually, an enzyme molecule has only one active site, and the active site fits with one specific type of substrate. An active site contains a binding site that binds the substrate and orients it for catalysis. Residues in the binding site form hydrogen bonds, hydrophobic interactions, or temporary covalent interactions (van der Waals) with the substrate to make an enzyme-substrate complex.
The decreased volume only disrupts the equilibrium if the moles of gaseous products and moles of gaseous reactants are unequal. If there are an equal number of moles of gaseous substances on both sides of the arrow, the change in volume has an equal effect on the concentrations of reactants and of products.
This results in an increase in volume. Density decreases Shape and Size If the temperature of a material remains constant, the size and shape will not affect itâs density. The mass and volume change proportionately. Phases of Matter For most substances particles are most closely packed in the solid phase. Most materials are densest in their solid phase.