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Review: could Prednisone cause Heartburn? Heartburn is found among people who take Prednisone, especially for people who are female, 50-59 old , have been taking the drug for 1 - 6 months, also take medication Ambien, and have Pain . We study 124,213 people who have side effects while taking Prednisone from FDA and social media. Among them, 149 have Heartburn.
Rating Newest Oldest. Best Answer: Prednisone can cause fluid retention which can put stress on a weak heart leading to congestive heart failure. But your doctor would have put you on steriods for a good reason. Hold the prednisone and call him.