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A: Hydrochlorothiazide (HCTZ) is a thiazide diuretic (water pill) that is used to treat edema (fluid retention) from various causes such as congestive heart failure, cirrhosis of the liver, kidney disorders, or medication-induced (from estrogen or steroids).
Thiazide diuretics. These drugs inhibit the sodium-chloride sympoter in the distal convoluted tubule, causing water to be retained in the urine. One example of a drug in this class is hydrochlorothiazide. The main conditions these agents are used to treat include: 1  Hypertension or high blood pressure. 2  Heart failure. 3  Kidney stones.