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Biology and Behavior. Striped skunks mate in February and early March. Females give birth in May, often in woodchuck burrows, to an average litter of six. It is not unusual to see a female skunk with a line of little black and white copies following her across a damp pasture or lawn on an early July morning.
Female mice are only receptive to male mice while they are in estrus. Mating generally occurs within 24 hours of introducing a male and an 'in estrus' female mouse, though the female is most receptive during the first few hours. There may be frequent, short copulations before adequate intromission and ejaculation occur.