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myelin sheath. noun. The insulating envelope of myelin that surrounds the core of a nerve fiber or axon and facilitates the transmission of nerve impulses. In the peripheral nervous system, the sheath is formed from the membrane of the Schwann cell, and in the central nervous system it is formed from oligodendrocytes.
The myelin sheath around most vertebrate axons provides a layer of insulation that prevents the loss of the electrical signal from an action potential. Myelin is lipid rich substance that does not conduct electricity well.ecause of the insulation provided by the myelin, action potentials can travel much more rapidly down myelinated axons than down unmyelinated axons. Myelin also isolates axons from one another in the white matter of the brain preventing the short-circuiting of nerve signals in the central nervous system.