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Hyperbaric oxygen increases the amount of plasma O2 (which diffuses into the tissues more easily). Increased O2 supply to damaged tissue leads to increased antimicrobial effects, induction and propagation of angiogenesis, vasoconstriction without tissue O2 loss (preventing edema), and fewer tissue bubbles.
This form of hyperbaric therapy which utilizes 100% of oxygen requires a prescription under FDA guidelines due to its classification as a drug. Mild hyperbaric therapy or mHBOT has also shown significant health benefits and administers 95% oxygen in a small range of 1.3 to 1.4 atmospheric pressure.