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A variety of factors -- ranging from emotional stress and trauma to streptococcal infection -- can cause an episode of psoriasis. Recent research indicates that some abnormality in the immune system is the key cause of psoriasis.
1 Hydroxychloroquine is the least likely to cause side effects. 2  Inderal: This high blood pressure medication worsens psoriasis in about 25 percent to 30 percent of patients with psoriasis who take it. 3  It is not known if all high blood pressure (beta blocker) medications worsen psoriasis, but they may have that potential.