The first building to use a steel frame in St. Louis was the Wainwright Building, a 10-story office building and one of the first modern skyscrapers. The building, which was designed by Louis Sullivan and Dankmar Adler, illustrates Sullivan's principle of form follows function.
keratinocyte. [keratâ²inÅsÄ«tâ²]. Etymology: Gk, keras + kytos, cell. an epidermal cell that synthesizes keratin and other proteins and sterols. These cells constitute 95% of the epidermis, being formed from undifferentiated, or basal, cells at the dermal-epidermal junction.
The keratinocytes originate from human epidermal stem cells present in the stratum germinativum (basal layer of epidermis). The progeny of these stem cells are termed transit amplifying (TA) cells. TA cells also reside in the basal layer and undergo mitosis.s the granulosum keratinocytes are pushed into lucidum layer, they become transparent or translucent and get flattened. The lucidum keratinocytes may be 3-5 layers in thickness and may undergo apoptosis releasing fatty substance. They contain a clear intermediate form of keratin called eleidin.