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Bitters usually do contain an alcohol content, with some ranging as high as 45%. However, it would be pretty hard to get a buzz from bitters because they are usually used in such small amounts to flavor a drink.
How To Make Homemade Bitters. From the medicine cabinet to the bar, bitters have a long history of curing ailments and flavoring drinks. Though they may seem mysterious, at heart, bitters are simply bitter and aromatic herbs and spices infused or tinctured in spirits. Combining the various flavors is where the fun part comes in.