A full job description is available on the Mount Pleasant Township website; mpt-pa.com. E-mail resume with certifications to mpt@mpt-pa.com, or submit in person at 31 McCarrell Road, Hickory, PA. Deadline to apply is September 5, 2107.
Genetic changes that are described as de novo (new) mutations can be either hereditary or somatic. In some cases, the mutation occurs in a personâs egg or sperm cell but is not present in any of the personâs other cells. In other cases, the mutation occurs in the fertilized egg shortly after the egg and sperm cells unite.
The smallest single base deletion mutations are believed occur by a single base flipping in the template DNA, followed by template DNA strand slippage, within the DNA polymerase active site. Deletions can be caused by errors in chromosomal crossover during meiosis, which causes several serious genetic diseases. Deletions that do not occur in multiples of three bases can cause a frameshift by changing the 3-nucleotide protein reading frame of the genetic sequence.