While carcinogenic contaminants are the primary concern, PEG compounds themselves show some evidence of genotoxicity vi,vii and if used on broken skin can cause irritation and systemic toxicity.
The average age of menopause in the United States is about 51. About one out of twenty women have late menopause (after age 55) while another 5% stop having periods between the ages of 40 and 45 (early menopause). The age of menopause is reduced by two years in women who smoke.
The average age for menopause in the United States is approximately 52 years, but the menopause transition can last for a number of years. During the menopause transition, women's ovaries produce less and less of the hormone estrogen, until menses stops completely. The loss of estrogen may cause hot flashes, night sweats, insomnia, headaches, irregular periods, and vaginal dryness.