Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
Pakistan's 2nd most populous city, Lahore, is only about half the size, with just 6.3 million people, but is still the world's 15th most populous city. Pakistan has six additional cities that have passed the one million population mark.
Pakistan is bordered by India on the east, the Arabian Sea on the south, Iran on the southwest, and Afghanistan on the west and north; in the northeast is the disputed territory (with India) of Kashmir, of which the part occupied by Pakistan borders on China. Islamabad is the capital and Karachi is the largest city.