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Diphenhydramine, Lorazepam, and Dexamethasone in Treating Nausea and Vomiting Caused By Chemotherapy. This study has been terminated. RATIONALE: Diphenhydramine, lorazepam, and dexamethasone may help lessen or prevent nausea and vomiting in patients treated with chemotherapy. It is not yet known whether diphenhydramine, lorazepam, and dexamethasone are more effective than standard therapy in treating nausea and vomiting caused by chemotherapy.
Benadryl (diphenhydramine) is an antihistamine used for allergies, hives, insomnia, motion sickness, and mild cases of Parkinsonism.A generic formulation is available.Common side effects of Benadryl include sedation, tiredness, sleepiness, dizziness, disturbed coordination, constipation, dry mouth/nose/throat, difficulty urinating, and upset stomach. typical dose of Benadryl is 25-50 mg every 4-6 hours. Benadryl adds to the sedating effects of alcohol and other sedating drugs. It can also intensify the drying effects of medications with anticholinergic properties. Benadryl has not been adequately evaluated in pregnant women. Benadryl is secreted in breast milk.