The first building to use a steel frame in St. Louis was the Wainwright Building, a 10-story office building and one of the first modern skyscrapers. The building, which was designed by Louis Sullivan and Dankmar Adler, illustrates Sullivan's principle of form follows function.
keratinocyte. [keratâ²inÅsÄ«tâ²]. Etymology: Gk, keras + kytos, cell. an epidermal cell that synthesizes keratin and other proteins and sterols. These cells constitute 95% of the epidermis, being formed from undifferentiated, or basal, cells at the dermal-epidermal junction.
The keratinocytes divide in the skin's mitotic layer. The innermost part of the epidermis, this is made up of a single line of keratinocytes held together and to the underlying dermis by desmosomes, a sort of press stud structure. Each keratinocyte divides to produce two identical daughter cells.erkel cells (6-10% of the cells in the epidermis), situated between the keratinocytes in the renewal layer, remain in contact with a nerve ending. They can be isolated or grouped together in clusters called Merkel corpuscles.