The first building to use a steel frame in St. Louis was the Wainwright Building, a 10-story office building and one of the first modern skyscrapers. The building, which was designed by Louis Sullivan and Dankmar Adler, illustrates Sullivan's principle of form follows function.
keratinocyte. [keratâ²inÅsÄ«tâ²]. Etymology: Gk, keras + kytos, cell. an epidermal cell that synthesizes keratin and other proteins and sterols. These cells constitute 95% of the epidermis, being formed from undifferentiated, or basal, cells at the dermal-epidermal junction.
Differentiation of Keratinocytes: Keratinocyte stem cells reside in the basal layer of the epidermis, which is the lowest layer of the stratified epithelia. These cells divide to give rise to transient amplifying cells which divide further, and differentiate, as they move upwards in the epidermis.