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Full Definition of CLEAVAGE. 1. a: the quality of a crystallized substance or rock of splitting along definite planes; also: the occurrence of such splitting b: a fragment (as of a diamond) obtained by splitting. 2. : the action of cleaving: the state of being cleft. 3.
Cleavage product 1 has two methylation sites. Mass signals of the cleavage product will differ by 32 Da when both CpG sites are either methylated or nonmethylated. For cleavage products 2 and 3, mass shifts of 16 Da will be observed, because each contains only one methylation site.