This can lead to drastic reductions in the amount available in the systemic circulation after oral administration. E.g. propanolol (a beta blocker) needs to be given in 100mg doses orally while intravenously (avoiding first-pass metabolism) only 5mg are needed.
home > bromocriptine (parlodel) index. Bromocriptine (Parlodel) is prescription drug used to treat hyperprolactinemia, acromegaly, and signs and symptoms of Parkinson's disease. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
See also: poloxamer. Pluronic P-123 is the tradename for a triblock copolymer manufactured by the BASF Corporation. The nominal chemical formula is HO(CH 2 CH 2 O) 20 (CH 2 CH(CH 3)O) 70 (CH 2 CH 2 O) 20 H, which corresponds to a molecular weight of around 5800 Da.otential Degradation by Sonication Wang et al. reported that aqueous solutions of poloxamer 188 (PluronicÂ® F-68) and poloxamer 407 (PluronicÂ® F-127) sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can became highly toxic to cultured cells.