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Diphenhydramine, Lorazepam, and Dexamethasone in Treating Nausea and Vomiting Caused By Chemotherapy. This study has been terminated. RATIONALE: Diphenhydramine, lorazepam, and dexamethasone may help lessen or prevent nausea and vomiting in patients treated with chemotherapy. It is not yet known whether diphenhydramine, lorazepam, and dexamethasone are more effective than standard therapy in treating nausea and vomiting caused by chemotherapy.
In addition to its use as a sleep aid, diphenhydramine is often administered to relieve allergies or treat allergic reactions, and can be helpful in preventing motion sickness. It is also used to alleviate extrapyramidal symptoms, which may occur as a side effect of other medications.