The first building to use a steel frame in St. Louis was the Wainwright Building, a 10-story office building and one of the first modern skyscrapers. The building, which was designed by Louis Sullivan and Dankmar Adler, illustrates Sullivan's principle of form follows function.
keratinocyte. [keratâ²inÅsÄ«tâ²]. Etymology: Gk, keras + kytos, cell. an epidermal cell that synthesizes keratin and other proteins and sterols. These cells constitute 95% of the epidermis, being formed from undifferentiated, or basal, cells at the dermal-epidermal junction.
Within the epidermis keratinocytes are associated with other cell types such as melanocytes and Langerhans cells. Keratinocytes form tight junctions with the nerves of the skin and hold the Langerhans cells and intra-dermal lymphocytes in position within the epidermis.