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A: Hydrochlorothiazide (HCTZ) is a thiazide diuretic (water pill) that is used to treat edema (fluid retention) from various causes such as congestive heart failure, cirrhosis of the liver, kidney disorders, or medication-induced (from estrogen or steroids).
What is the mechanism of action of HCTZ? How does HCTZ work in the body? Hydrochlorothiazide (HCTZ) is a thiazide diuretic. Diuretics work by increasing the amount of fluid excreted by the kidneys. HCTZ reduces the amount of salt (sodium chloride) reabsorbed from the urine by the body in the kidneys at place call the distal convoluted tubule.