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Review: could Prednisone cause Heartburn? Heartburn is found among people who take Prednisone, especially for people who are female, 50-59 old , have been taking the drug for 1 - 6 months, also take medication Ambien, and have Pain . We study 124,213 people who have side effects while taking Prednisone from FDA and social media. Among them, 149 have Heartburn.
A Stacy Wiegman, PharmD , Pharmacy, answered. All medicines are capable of producing side effects, and prednisone is no exception. Prednisone can cause allergic reactions (chest tightness, trouble breathing, rash, itching, facial swelling, hives or swelling in the mouth or throat), which warrant immediate medical attention.