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Pharmacology and Pharmacokinetics. The mechanism of action of Diclegis is unknown.1. Peak plasma concentrations of the doxylamine component occur in 7.5 hours, and the pyridoxine component, 5.5 hours. Elimination half-life is 12.5 hours for the doxylamine component, and in 0.5 hours for the pyridoxine component. Steady-state concentrations of doxylamine are reached within 24 to 48 hours. Pyridoxine does not reach steady-state concentrations due to its short half-life.1.
Prescription Diclegis (10 mg pyridoxine/10 mg doxylamine) costs around $570 for 100 tablets. Many patients may require two to four tablets per day. Over-the-counter 25 mg pyridoxine and 20 mg doxylamine each cost $5 to $10 for 100 tablets.The prescription version may be cost-prohibitive for some patients, in which case the over-the-counter combination is a viable alternative.he most common side effect is drowsiness (occurring in 14% of patients), a result of the central antihistamine activity. Serious side effects are extremely rare. Patients should be instructed to take the medication at night when starting it, and to use caution if taking it prior to driving or operating machinery.