A: Wellbutrin (bupropion) is a dopamine reuptake inhibitor antidepressant used to treat depression. The most common side effects with Wellbutrin are headache, insomnia, dry mouth, increased heart rate, weight loss, and nausea.: Wellbutrin (bupropion) is a dopamine-reuptake inhibitor antidepressant which is used for the treatment of major depressive disorder. There are long-acting forms of bupropion which are used for smoking cessation and to treat seasonal affective disorder.
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