: a statement that is known or believed by its maker to be incorrect or untrue and is made esp. with intent to deceive or mislead [submitted a false statement to obtain the loan]. ;also.
Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia. pharmacokinetics. the study of the movement of drugs in the body, including the processes of absorption, distribution, localization in tissues, biotransformation, and excretion. adj., adj pharmacokinetÂ´ic.
Pharmacodynamics, with pharmacokinetics (what the body does to a drugâsee Pharmacokinetics), helps explain the relationship between the dose and response, ie, the drug's effects. The pharmacologic response depends on the drug binding to its target. The concentration of the drug at the receptor site influences the drugâs effect. A drugâs pharmacodynamics can be affected by physiologic changes due to disorders, aging, or other drugs. Disorders that affect pharmacodynamic responses include genetic mutations, thyrotoxicosis, malnutrition, myasthenia gravis, Parkinson disease, and some forms of insulin -resistant diabetes mellitus.