About Odessa Regional Medical Center Odessa Regional Medical Center is a Hospital in Odessa, TX.
The most important reward pathway in brain is the mesolimbic dopamine system. This circuit (VTA-NAc) is a key detector of a rewarding stimulus.
The âHighâ From Drugs/Pleasure Effect. Most drugs of abuseânicotine, cocaine, marijuana, and othersâaffect the brainâs ârewardâ circuit, which is part of the limbic system. Normally, the reward circuit responds to feelings of pleasure by releasing the neurotransmitter dopamine. Dopamine creates feelings of pleasure.