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A: Hydrochlorothiazide (HCTZ) is a thiazide diuretic (water pill) that is used to treat edema (fluid retention) from various causes such as congestive heart failure, cirrhosis of the liver, kidney disorders, or medication-induced (from estrogen or steroids).
Absorption of Hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the Hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85% and 43%, respectively.