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Spinal Cord Injury: Paraplegic and Quadriplegic Injuries. Paraplegia is the paralysis of both lower limbs resulting (with exceptions) from a spinal cord injury, most often the result of some sort of trauma caused by accidents, but sometimes due to medical conditions (illness).
Spastic paraplegia type 2 is part of a group of genetic disorders known as hereditary spastic paraplegias.These disorders are characterized by progressive muscle stiffness (spasticity) and the development of paralysis of the lower limbs (paraplegia).Hereditary spastic paraplegias are divided into two types: pure and complex.utations in the PLP1 gene cause spastic paraplegia 2. The PLP1 gene provides instructions for producing proteolipid protein 1 and a modified version (isoform) of proteolipid protein 1, called DM20.