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Mechanism of Typical antipsychotic drugs. All typical antipsychotics block dopamine D2 receptors (inc [cAMP]) in the limbic system of the brain. These drugs also produce some inhibition at the H1 histamine receptors, cholinergic, and alpha-adrenergic receptors, which leads to a host of undesirable SE.
Finally, some drugs alter neurotransmission by means other than increasing or decreasing the quantity of receptors stimulated. Benzodiazepines, such as diazepam or lorazepam, enhance receiving cells' responses when the neurotransmitter gamma-aminobutyric acid (GABA) attaches to their receptors.