At the terminal end of the axon is a branched structure with ends called synaptic knobs. From this structure chemical signals can be sent to neighboring neurons. Transmission of nerve impulse along the axon
When an action potential reaches the axon terminal of a motor neuron, vesicles carrying neurotransmitters (mostly acetylcholine) are exocytosed and the contents are released into the neuromuscular junction.These neurotransmitters bind to receptors on the postsynaptic membrane and lead to its depolarization.he small depolarization associated with the release of acetylcholine from one synaptic vesicle is called a miniature end-plate potential (MEPP). MEPPs are additive and lead to a greater depolarization of the postsynaptic membrane and become end plate potentials (EPPs).
The process of using and reusing synaptic vesicles is a fascinating one. Vesicles are manufactured in the cell body, not in the endfoot. Fresh vesicles, filled with neurotransmitter substance and various complexes of enzymes, are shipped from the cell body down the axon to the endfeet of the neuron.