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Amitriptyline is a popular antidepressant that's available only in generic form in the U.S. It used to be sold under the brand name Elavil. Amitriptyline is classified as a tricyclic antidepressant. For years, some doctors have considered it a front-line treatment for fibromyalgia and chronic fatigue syndrome (ME/CFS). However, this came about more from trial-and-error use than clinical studies.
Tricyclic and tetracyclic antidepressants, also called cyclic antidepressants, were among the earliest antidepressants developed. They're effective, but they've generally been replaced by antidepressants that cause fewer side effects.yclic antidepressants are designated as tricyclic or tetracyclic, depending on the number of rings in their chemical structure â three (tri) or four (tetra). Those approved by the Food and Drug Administration to treat depression are listed below. Tricyclic antidepressants: 1  Amitriptyline.