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Review: could Prednisone cause Heartburn? Heartburn is found among people who take Prednisone, especially for people who are female, 50-59 old , have been taking the drug for 1 - 6 months, also take medication Ambien, and have Pain . We study 124,213 people who have side effects while taking Prednisone from FDA and social media. Among them, 149 have Heartburn.
Other common prednisone side effects may include: 1  sleep problems (insomnia), mood changes; 2  increased appetite, gradual weight gain; 3  acne, increased sweating, dry skin, thinning skin, bruising or discoloration;  slow wound 1  healing; headache, dizziness, spinning sensation;  nausea, stomach pain, bloating; or.