About Odessa Regional Medical Center Odessa Regional Medical Center is a Hospital in Odessa, TX.
The most important reward pathway in brain is the mesolimbic dopamine system. This circuit (VTA-NAc) is a key detector of a rewarding stimulus.
THE PLEASURE CENTRES AFFECTED BY DRUGS. The nucleus accumbens definitely plays a central role in the reward circuit. Its operation is based chiefly on two essential neurotransmitters: dopamine, which promotes desire, and serotonin, whose effects include satiety and inhibition.Many animal studies have shown that all drugs increase the production of dopamine in the nucleus accumbens, while reducing that of serotonin.ocated in the midbrain, at the top of the brainstem, the VTA is one of the most primitive parts of the brain. It is the neurons of the VTA that synthesize dopamine, which their axons then send to the nucleus accumbens.