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Review: could Prednisone cause Heartburn? Heartburn is found among people who take Prednisone, especially for people who are female, 50-59 old , have been taking the drug for 1 - 6 months, also take medication Ambien, and have Pain . We study 124,213 people who have side effects while taking Prednisone from FDA and social media. Among them, 149 have Heartburn.
Prolonged use of prednisone can cause adrenal glands to atrophy and stop producing cortisol. People who take prednisone are often warned not to stop the medication suddenly. After long-term use, the dose of prednisone must be tapered gradually to allow the adrenal glands, which may have atrophied, time to recover.