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Diphenhydramine, Lorazepam, and Dexamethasone in Treating Nausea and Vomiting Caused By Chemotherapy. This study has been terminated. RATIONALE: Diphenhydramine, lorazepam, and dexamethasone may help lessen or prevent nausea and vomiting in patients treated with chemotherapy. It is not yet known whether diphenhydramine, lorazepam, and dexamethasone are more effective than standard therapy in treating nausea and vomiting caused by chemotherapy.
Diphenhydramine (Injection) is an analgesic and antihistamine that is FDA approved for the treatment of allergic reactions to blood or plasma, uncomplicated allergic conditions of the immediate type, in anaphylaxis as an adjunct to epinephrine, motion sickness and parkinsonism.