About Odessa Regional Medical Center Odessa Regional Medical Center is a Hospital in Odessa, TX.
The most important reward pathway in brain is the mesolimbic dopamine system. This circuit (VTA-NAc) is a key detector of a rewarding stimulus.
4.2a Serotonin. Even though increased dopamine in the brain reward system is generally thought to be the final common pathway for the reinforcing properties of drugs, other neurotransmitters such as serotonin are involved in the modulation of both drug self-administration and dopamine levels.ike other drugs of abuse, stimulants increase dopamine concentrations in the brain reward pathway (1,2,3,4,7). Stimulants such as cocaine, amphetamines, caffeine and nicotine all stimulate the brain reward pathway through slightly different mechanisms and increase dopamine to different extents.