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Review: could Prednisone cause Heartburn? Heartburn is found among people who take Prednisone, especially for people who are female, 50-59 old , have been taking the drug for 1 - 6 months, also take medication Ambien, and have Pain . We study 124,213 people who have side effects while taking Prednisone from FDA and social media. Among them, 149 have Heartburn.
Answer by jsteiny03 (346). Prednisone has some serious side effects like weight gain, water retention, night sweats, eye sight decrease ect. After you stop taking prednisone it may take up to a week to completely get out of your system but will take longer for some of the side effects to disappear.rednisone has some serious side effects like weight gain, water retention, night sweats, eye sight decrease ect. After you stop taking prednisone it may take up to a week to completely get out of your system but will take longer for some of the side effects to disappear.