Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
The city is the political seat of Pakistan and is administered by Capital Development Authority (CDA). Islamabad is located in the Pothohar Plateau in the northeastern part of the country, between Rawalpindi District and the Margalla Hills National Park to the north.