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Pharmacology and Pharmacokinetics. The mechanism of action of Diclegis is unknown.1. Peak plasma concentrations of the doxylamine component occur in 7.5 hours, and the pyridoxine component, 5.5 hours. Elimination half-life is 12.5 hours for the doxylamine component, and in 0.5 hours for the pyridoxine component. Steady-state concentrations of doxylamine are reached within 24 to 48 hours. Pyridoxine does not reach steady-state concentrations due to its short half-life.1.
Haloperidol half-life after chronic dosing. J Clin Psychopharmacol. 2004; 24(6):656-60 (ISSN: 0271-0749) In normal subjects after a single oral dose, haloperidol half-life has been reported to range 14.5-36.7 hours (or up to 1.5 days). After chronic administration, half-lives of up to 21 days have been reported.