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Pharmacology and Pharmacokinetics. The mechanism of action of Diclegis is unknown.1. Peak plasma concentrations of the doxylamine component occur in 7.5 hours, and the pyridoxine component, 5.5 hours. Elimination half-life is 12.5 hours for the doxylamine component, and in 0.5 hours for the pyridoxine component. Steady-state concentrations of doxylamine are reached within 24 to 48 hours. Pyridoxine does not reach steady-state concentrations due to its short half-life.1.
The biological half life of a substance is the time it takes for a drug to lose half of its pharmacologic activity. This is significant because it affects how soon withdrawal symptoms may appear. The half life of Zyprexa is between 21 and 54 hours. Zyprexa is mainly metabolized through the P450 pathway in the liver and the enzymes primarily handling the metabolism is CYP1A2 and CYP2D6.