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Diphenhydramine, Lorazepam, and Dexamethasone in Treating Nausea and Vomiting Caused By Chemotherapy. This study has been terminated. RATIONALE: Diphenhydramine, lorazepam, and dexamethasone may help lessen or prevent nausea and vomiting in patients treated with chemotherapy. It is not yet known whether diphenhydramine, lorazepam, and dexamethasone are more effective than standard therapy in treating nausea and vomiting caused by chemotherapy.
Benadryl (diphenhydramine): I have emtophobia, that is, a pervasive fear of vomiting. I do not know if this affects vomiting, but if I feel nauseous, Benadryl works wonders. My stomach settles right down and my anxiety lowers just enough for me to deal with it without the use of benzodiazepines..