A full job description is available on the Mount Pleasant Township website; mpt-pa.com. E-mail resume with certifications to mpt@mpt-pa.com, or submit in person at 31 McCarrell Road, Hickory, PA. Deadline to apply is September 5, 2107.
Genetic changes that are described as de novo (new) mutations can be either hereditary or somatic. In some cases, the mutation occurs in a personâs egg or sperm cell but is not present in any of the personâs other cells. In other cases, the mutation occurs in the fertilized egg shortly after the egg and sperm cells unite.
However, these mistakes are rare, and the cell has repair mechanisms that can repair some damage. - Sometimes a permanent change occurs in a cell's DNA and this is called a mutation. - Because a mutation in a gene causes a change in the protein that is made, the enzyme is nonfunctional. Types of mutations - Mutations can range from changes in a single base pair in the coding sequence of DNA to the deletions of large pieces of chromosomes. - Point mutations involve a chemical change in just one base pair and can be enough to cause a genetic disorder. - A point mutation in which one base is exchanged for another is called a substitution. - Most substitutions are missense mutations, where the DNA code is altered so that it codes for the wrong amino acid. - Other substitutions, called nonsense mutations, change the codon for an amino acid to a stop codon. Nonsense mutations cause translation to terminate early. Nearly all nonsense mutations lead to proteins that cannot function normally. - Another type of mutation that can occur involves the gain or loss of a nucleotide in the DNA sequence.