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Chantix is notorious for causing very bad dreams. Other medications that may trigger nightmares include antibiotics (such as Avelox, Biaxin, Cipro and Levaquin), antidepressants (like Cymbalta, Effexor, Lexapro and Paxil), beta blockers (atenolol, bisoprolol, labetalol, metoprolol and propranolol) and levodopa for Parkinsonâs, among others.
How they can cause fatigue: Antipsychotics are drugs that dull the activity of the central nervous system. In studies, the side effects include fatigue, lethargy and weakness. Many of these drugs also lower dopamine levels, which can lead to drowsiness and sleepiness as well.