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Mechanism of Typical antipsychotic drugs. All typical antipsychotics block dopamine D2 receptors (inc [cAMP]) in the limbic system of the brain. These drugs also produce some inhibition at the H1 histamine receptors, cholinergic, and alpha-adrenergic receptors, which leads to a host of undesirable SE.
Beta-blockers are drugs that bind to beta-adrenoceptors and thereby block the binding of norepinephrine and epinephrine to these receptors. This inhibits normal sympathetic effects that act through these receptors. Therefore, beta-blockers are sympatholytic drugs. Some beta-blockers, when they bind to the beta-adrenoceptor, partially activate the receptor while preventing norepinephrine from binding to the receptor. These partial agonists therefore provide some background of sympathetic activity while preventing normal and enhanced sympathetic activity.