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have been ruled out, a patient is diagnosed with oral leukoplakia. While the long-term history of these. lesions is impossible to predict, it is known that true leukoplakias are considered âpotentially. malignant,â meaning that they have the potential, over time, to develop into oral cancer. Oral leukoplakia occurs in 1-2% of the population and is most common in patients over age 40. It may. affect any part of the mouth.
Key points about oral hairy leukoplakia. 1  Oral hairy leukoplakia is a condition that the Epstein-Barr virus can trigger. 2  It happens most often in people whose immune systems are very weak and is most often seen in people with HIV. 3  The condition causes white lesions, or patches, on the tongue.