Macrocytosis - Pathophysiology. 1  The most common cause of macrocytic anemia is megaloblastic anemia, which is the result of impaired DNA synthesis. 2  Vitamin B-12 and folate coenzymes are required for thymidylate and purine synthesis; thus, their deficiency results in retarded DNA synthesis.
(You may want to read the articles about Scales, the Major Scale, or Key Signatures first.) There are 12 different Major Scales: One with no sharps or flats, 4 with sharps, 4 with flats, and 3 with either sharps or flats depending upon enharmonic spelling. Major Scales with no sharps or flats: C Major. Major Scales with sharps: D, E, G, A. Major Scales with flats: E-flat, F, A-flat, B-flat.
The three kinds of minor scale are called the natural minor scale, the harmonic minor scale, and the melodic minor scale. For the purposes of this mini-course it is not necessary for you to understand or to hear the differences between the three kinds of minor scale.he most reliable way to tell the difference between major and minor scales is by focusing on the lower part of the scale. In particular, of the first five notes of the scale, only one, the third note, is ever different between major and minor scales.