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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin. Lee CH(1), Ruben PC. Author information: (1)School of Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.Tetrodotoxin (TTX) is a potent toxin that specifically binds to voltage gated sodium channels.TTX binding physically blocks the flow of sodium ions through the channel, thereby preventing action potential (AP) generation and propagation.nteraction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin. Lee CH(1), Ruben PC. Author information: (1)School of Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.