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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
Gated Channels. Protein channels in the phospholipid bilayer of the neuron have the ability to let in/out certain kinds of ions. Open chemically, mechanically or electrically. Mechanical/chemical gates located in the dendrite. Voltage gates located in the axon hillock area.