Tumor lysis syndrome. Tumor lysis syndrome (TLS) is a group of metabolic abnormalities that can occur as a complication during the treatment of cancer, where large amounts of tumor cells are killed off (lysed) at the same time by the treatment, releasing their contents into the bloodstream.
The Trevi Fountain that stands in Trevi Square today was designed by Roman architect Nicola Salvi. Building began in 1732 and concluded three decades later. Before his death in 1751, Salvi chose young artist Giuseppe Pannini as his successor.
Sheaffer Pen Corporation (ÊeÉªfÉË) is a manufacturer of writing instruments, particularly luxury fountain pens. The company was founded by Walter A. Sheaffer in Fort Madison, Iowa, and incorporated in 1913 to exploit his invention of a lever-filling fountain pen.