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Gastrointestinal perforation. Perforation is a hole that develops through the wall of a body organ. This problem may occur in the esophagus, stomach, small intestine, large intestine, rectum, or gallbladder. Perforation of an organ can be caused by a variety of factors. 1  These include: 2  Appendicitis. 3  Cancer. 4  Crohn disease. 5  Diverticulitis. 6  Gallbladder disease. 7  Peptic ulcer disease. 8  Ulcerative colitis. 9  Bowel blockage. 10  Chemotherapy agents.
Other Gastrointestinal Causes. 1  Esophageal Ulcer. 2  A consequence of GERD and occasionally H.pylori infection, the erosion in the lining of the esophagus often causes constant chest pain that is worse during eating. Other complications of long standing GERD or H.pylori infection like esophageal cancer or Barrettâs esophagus may also be responsible.