Macrocytosis - Pathophysiology. 1  The most common cause of macrocytic anemia is megaloblastic anemia, which is the result of impaired DNA synthesis. 2  Vitamin B-12 and folate coenzymes are required for thymidylate and purine synthesis; thus, their deficiency results in retarded DNA synthesis.
(You may want to read the articles about Scales, the Major Scale, or Key Signatures first.) There are 12 different Major Scales: One with no sharps or flats, 4 with sharps, 4 with flats, and 3 with either sharps or flats depending upon enharmonic spelling. Major Scales with no sharps or flats: C Major. Major Scales with sharps: D, E, G, A. Major Scales with flats: E-flat, F, A-flat, B-flat.
The most common scale in all music is the major scale. Youâll hear it all over the place (pretty much every nursery rhyme, Christmas carol and national anthem uses it) and itâs the basis of all chords. The major scale creates a particular pattern on the ukulele. This pattern can be moved up and down the neck depending on which key you play in. The most important note to concentrate on is the root note â the first one played and the last one played.