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Gastrointestinal perforation. Perforation is a hole that develops through the wall of a body organ. This problem may occur in the esophagus, stomach, small intestine, large intestine, rectum, or gallbladder. Perforation of an organ can be caused by a variety of factors. 1  These include: 2  Appendicitis. 3  Cancer. 4  Crohn disease. 5  Diverticulitis. 6  Gallbladder disease. 7  Peptic ulcer disease. 8  Ulcerative colitis. 9  Bowel blockage. 10  Chemotherapy agents.
perforation. a hole or break in the containing walls or membranes of an organ or structure of the body. Perforation occurs when erosion, infection, or other factors create a weak spot in the organ and internal pressure causes a rupture. It also may result from a deep penetrating wound caused by trauma.ccurs when an infectious process erodes the tympanic membrane or leads to increased pressure in the middle ear. esophageal perforation. causes local cellulitis and obstruction of the esophagus. gallbladder perforation. sometimes occurs as a complication of cholecystitis and gallstones.