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Late winter (February-March) is the best time to prune crape myrtles in eastern North Carolina. Like all trees, the correct way to prune a crape myrtle involves enhancing its natural form rather than trying to force it to grow in a space that is too small or an artificial shape.
Then there is pruning tree roses as well as pruning knockout rose bushes. The signs for pruning rose bushes in the spring are the swelling of the rose buds. So therefore the best time to prune your roses is in early spring when those buds just begin to swell. Keep in mind that a rose is basically just a flowering shrub, and also that it's very hard to do any real harm to the rose bush if you do not prune like a pro the first time.