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The most common side effects of niacin are: stomach upset, flushing, headache, reduced blood pressure upon standing (orthostatic hypotension), vomiting, diarrhea, itching and ; tingling sensations of the extremities. Flushing may be reduced by taking 325 mg of aspirin 30 minutes before the niacin and by increasing the dose of niacin slowly.
If one starts on a low dose and slowly increase the amount of Niacin over several weeks, the flushing effects are minimal. If you stop for a few days, it may take a while for you body to get use to it again and flushing will be somewhat worse. Also, taking some aspirin a little before the Niacin reduces flushing.