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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
Chloride channels in excitable tissues function in the same way as the potassium channel in that they serve to dampen the electrical excitability of the neuron. GABA(A) and glycine receptor chloride channels function in the postsynaptic neuron as well as skeletal tissue.