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Gastrointestinal perforation. Perforation is a hole that develops through the wall of a body organ. This problem may occur in the esophagus, stomach, small intestine, large intestine, rectum, or gallbladder. Perforation of an organ can be caused by a variety of factors. 1  These include: 2  Appendicitis. 3  Cancer. 4  Crohn disease. 5  Diverticulitis. 6  Gallbladder disease. 7  Peptic ulcer disease. 8  Ulcerative colitis. 9  Bowel blockage. 10  Chemotherapy agents.
Peritonitis is inflammation of the abdominal cavity. Septic peritonitis most commonly. results from gastrointestinal (GI) rupture, perforation or dehiscence. GI perforation can occur. following penetrating trauma from bite wounds, stab wounds, gunshot wounds and foreign. bodies. Blunt trauma can cause mesenteric avulsion with ischemic injury to the GI tract and.