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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
Calcium-channel blockers; Beta-blockers; Cardiac Glycosides; 1. Calcium channel blockers prevent or slow the flow of calcium ions into smooth muscle cells such as the heart and blood vessels. Calcium channel blockers are preferred if you have heart or lung disease. Common side effects are the heart beats too slowly, constipation, low blood pressure and heart failure. 14 âCalcium channel blockers weaken the heart and can damage the liver,â according to Dr. Julian Whitaker in his Health & Healing newsletter of October 2015.