Tumor lysis syndrome. Tumor lysis syndrome (TLS) is a group of metabolic abnormalities that can occur as a complication during the treatment of cancer, where large amounts of tumor cells are killed off (lysed) at the same time by the treatment, releasing their contents into the bloodstream.
The Trevi Fountain that stands in Trevi Square today was designed by Roman architect Nicola Salvi. Building began in 1732 and concluded three decades later. Before his death in 1751, Salvi chose young artist Giuseppe Pannini as his successor.
In 1892 Stucchi Prinetti & Stucchi began manufacturing bicycles. In 1914 Alfonso Calzolari rode a Stucchi to victory in the Giro d'Italia, and the 1919 Giro d'Italia was won by Costante Girardengo on a Stucchi.n 1899 Prinetti & Stucchi started manufacturing motorized tricycles and quadricycles. The Tipo 1, a motorized tricycle utilizing two De Dion engines and a Rochet-Schneider frame, was designed by Ettore Bugatti. In 1900 Bugatti participated in the Targa Rignano in a quadricycle.