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Shirley is a town in Piscataquis County, Maine, United States. The town was named after Shirley, Massachusetts. The population was 233 at the 2010 census.
On October 4th, 2017, Deputies from the Van Buren County Sheriff's Office, attempted to stop a vehicle for speeding 75 mph in a 30 mph zone in Shirley. Deputies got into a pursuit with the vehicle, that would not spot for deputies after they activated their emergency lights and siren.