Macrocytosis - Pathophysiology. 1  The most common cause of macrocytic anemia is megaloblastic anemia, which is the result of impaired DNA synthesis. 2  Vitamin B-12 and folate coenzymes are required for thymidylate and purine synthesis; thus, their deficiency results in retarded DNA synthesis.
(You may want to read the articles about Scales, the Major Scale, or Key Signatures first.) There are 12 different Major Scales: One with no sharps or flats, 4 with sharps, 4 with flats, and 3 with either sharps or flats depending upon enharmonic spelling. Major Scales with no sharps or flats: C Major. Major Scales with sharps: D, E, G, A. Major Scales with flats: E-flat, F, A-flat, B-flat.
The difference between major and minor chords and scales boils down to a difference of one essential note  the third. The third is what gives major-sounding scales and chords their brighter, cheerier sound, and what gives minor scales and chords their darker, sadder sound. minor 3rd is one note lower than a major 3rd. Here is an example of a major 3rd (C to E) and a minor 3rd (C to Eb) [Click the play button on the diagrams to hear them.]: