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Shirley is a town in Piscataquis County, Maine, United States. The town was named after Shirley, Massachusetts. The population was 233 at the 2010 census.
The estimated population of Maine was 1,329,328 in July 2015, a year-over-year decline of 928 people, according to the American Community Survey, an annual statistical snapshot conducted by the U.S. Census Bureau.