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Gastrointestinal perforation. Perforation is a hole that develops through the wall of a body organ. This problem may occur in the esophagus, stomach, small intestine, large intestine, rectum, or gallbladder. Perforation of an organ can be caused by a variety of factors. 1  These include: 2  Appendicitis. 3  Cancer. 4  Crohn disease. 5  Diverticulitis. 6  Gallbladder disease. 7  Peptic ulcer disease. 8  Ulcerative colitis. 9  Bowel blockage. 10  Chemotherapy agents.
Gastroparesis occurs when the stomachâs normal electrical activity stops functioning correctly or when muscles don't respond to these electrical signals. This results in slowness in emptying the food into the small intestine with resultant symptoms. The most common causes for gastroparesis are: 1  Diabetes. 2  Thyroid disease. 3  Medications. Stomach surgery.  Neurologic and neuromuscular diseases such as Parkinsonâs Disease and Multiple 1  Sclerosis. Autoimmune diseases like lupus.  Diseases that may infiltrate the stomach like amyloidosis and 1  scleroderma. Viral infections.