Macrocytosis - Pathophysiology. 1  The most common cause of macrocytic anemia is megaloblastic anemia, which is the result of impaired DNA synthesis. 2  Vitamin B-12 and folate coenzymes are required for thymidylate and purine synthesis; thus, their deficiency results in retarded DNA synthesis.
(You may want to read the articles about Scales, the Major Scale, or Key Signatures first.) There are 12 different Major Scales: One with no sharps or flats, 4 with sharps, 4 with flats, and 3 with either sharps or flats depending upon enharmonic spelling. Major Scales with no sharps or flats: C Major. Major Scales with sharps: D, E, G, A. Major Scales with flats: E-flat, F, A-flat, B-flat.
(2.2) Intervals of the Major Scale. The Major scale is by far the most common scale in western music. When played in sequence, the notes of the Major scale make the famous do-re-mi-fa-so-la-ti-do sound. This characteristic sound of the Major scale is created by the pattern of intervals between its notes. There are seven notes in the Major scale and seven intervals between them. This pattern is: When this pattern is used to extract notes from the Chromatic scale, we arrive at the Major scale. Adding the semitone interval sizes together (2+2+1+2+2+2+1) gives a total of 12, the number of semitones in a octave. This is also true for every other (non-Major) scale type.