itchiness (pruritus). Pruritus is the primary symptom of cholestasis and is thought to be due to interactions of serum bile acids with opioidergic nerves. In fact, the opioid antagonist naltrexone is used to treat pruritus due to cholestasis. jaundice. Jaundice is an uncommon occurrence in intrahepatic (metabolic) cholestasis, but is common in obstructive cholestasis.
The Sun is the closest star to Earth, about 93 million miles away. The Sunâs nearest neighbor, Alpha Centauri, is actually a triple-star system âthree stars bound together by gravity. Alpha Centauri A and B are two bright, closely orbiting stars with a distant, dim companion, Proxima Centauri.
Proxima Centauri-Type= M5, Magnitude=11.0, Distance=4.22 ly. This dim red dwarf is the nearest star to the Sun, and it is a member of the Alpha Centauri system despite lying 0.24 light years from the main pair of stars, requiring over one million years to orbit them. Proxima was discovered in 1915 by Robert Innes and was at that time the least luminous star known.