Around 1875, the game of poker adopted the joker as a wild card. They have been a standard part of American playing card decks since the 1940s. Jokers as a Nickname for a Pair of Jacks. The second meaning of jokers is a slang term for a pair of jacks in Texas Hold'em.
Inheritance and Genetics of Intersex conditions. Genetics of Intersex conditions: Some intersex conditions are caused by chromosome deletions and duplications, while other conditions are due to specific chromosome mutations that may be inherited. Inheritance of Intersex conditions refers to whether the condition is inherited from your parents or runs in families. The level of inheritance of a condition depends on how important genetics are to the disease.
Humans are diploid organisms. We have two copies of each gene, inherited from each parent (the exception here is for males, who have only one X chromosome inherited from the mother, and lack many compensatory genes on the Y chromosome inherited from the father). Our own parents have two copies of each gene, one inherited from each of their parents. Therefore, one can model a grandchild from two pairs of grandparents as a mosaic of the genes of the four ancestral grandparents. But, the relationship between grandparent and grandchild is not deterministic at any given locus.