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have been ruled out, a patient is diagnosed with oral leukoplakia. While the long-term history of these. lesions is impossible to predict, it is known that true leukoplakias are considered âpotentially. malignant,â meaning that they have the potential, over time, to develop into oral cancer. Oral leukoplakia occurs in 1-2% of the population and is most common in patients over age 40. It may. affect any part of the mouth.
In patients with CD4 count greater than or equal to 300/Î¼L, oral hairy leukoplakia is associated with median survival time of 25 months, compared to 52 months in patients with normal counts. In patients with HIV, the median CD4 count when oral hairy leukoplakia is first detected is 468/ÂµL.