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The most common side effects of niacin are: stomach upset, flushing, headache, reduced blood pressure upon standing (orthostatic hypotension), vomiting, diarrhea, itching and ; tingling sensations of the extremities. Flushing may be reduced by taking 325 mg of aspirin 30 minutes before the niacin and by increasing the dose of niacin slowly.
Niacin is popularly believed to rapidly flush out marijuana and even cocaine to produce a negative test. The idea behind this is that niacin (vitamin B3) has been largely used as a traditional therapeutic vitamin to break down fats, proteins and carbohydrates.he concept that revolves around the relationship between niacin and drug test can be very risky. The problem with taking niacin in large doses is that it leads to unwanted side effects. The most notable side effect that is immediately felt is skin flushing and warmth, which may be coupled with itching and rashes.