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Gastrointestinal perforation. Perforation is a hole that develops through the wall of a body organ. This problem may occur in the esophagus, stomach, small intestine, large intestine, rectum, or gallbladder. Perforation of an organ can be caused by a variety of factors. 1  These include: 2  Appendicitis. 3  Cancer. 4  Crohn disease. 5  Diverticulitis. 6  Gallbladder disease. 7  Peptic ulcer disease. 8  Ulcerative colitis. 9  Bowel blockage. 10  Chemotherapy agents.
1 Any of these conditions can allow bacteria to get into the peritoneum through a hole in your gastrointestinal tract. 2  Pancreatitis. 3  Inflammation of your pancreas (pancreatitis) complicated by infection may lead to peritonitis if the bacteria spread outside the pancreas. 4  Diverticulitis.ommon causes of ruptures that lead to peritonitis include: 1  Medical procedures, such as peritoneal dialysis. 2  A ruptured appendix, stomach ulcer or perforated colon. 3  Pancreatitis. 4  Diverticulitis. 5  Trauma.