itchiness (pruritus). Pruritus is the primary symptom of cholestasis and is thought to be due to interactions of serum bile acids with opioidergic nerves. In fact, the opioid antagonist naltrexone is used to treat pruritus due to cholestasis. jaundice. Jaundice is an uncommon occurrence in intrahepatic (metabolic) cholestasis, but is common in obstructive cholestasis.
The Sun is the closest star to Earth, about 93 million miles away. The Sunâs nearest neighbor, Alpha Centauri, is actually a triple-star system âthree stars bound together by gravity. Alpha Centauri A and B are two bright, closely orbiting stars with a distant, dim companion, Proxima Centauri.
1 There is a maximum of 2,500 stars visible to the naked eye at any one time in the night sky. 2  The nearest star to our solar system is Proxima Centauri which is 4.2 light years away.  The Sun is part of a single star system but there are also binary and multiple stars where two or more stars orbit around each other.