itchiness (pruritus). Pruritus is the primary symptom of cholestasis and is thought to be due to interactions of serum bile acids with opioidergic nerves. In fact, the opioid antagonist naltrexone is used to treat pruritus due to cholestasis. jaundice. Jaundice is an uncommon occurrence in intrahepatic (metabolic) cholestasis, but is common in obstructive cholestasis.
The Sun is the closest star to Earth, about 93 million miles away. The Sunâs nearest neighbor, Alpha Centauri, is actually a triple-star system âthree stars bound together by gravity. Alpha Centauri A and B are two bright, closely orbiting stars with a distant, dim companion, Proxima Centauri.
The nearest star beyond the Sun, Alpha Centauri, has a magnitude of zero. Sirius, the brightest star besides the sun, has a magnitude of -1.4. Venus at its brightest has a magnitude of -4. A crescent Moon is about magnitude -8, the full Moon about -12.