Lyme disease is transmitted to humans by the bite of infected ticks of the Ixodes genus. Usually, the tick must be attached for 36 to 48 hours before the bacteria can spread. In North America, Borrelia burgdorferi sensu stricto and Borrelia mayonii are the cause.
A genetic predisposition (sometimes also called genetic susceptibility) is an increased likelihood of developing a particular disease based on a personâs genetic makeup. A genetic predisposition results from specific genetic variations that are often inherited from a parent.he World Health Organization offers information about genetic predisposition to several common diseases, including cancer, diabetes, cardiovascular disease, and asthma. Genetic Alliance UK offers a fact sheet on genetic predisposition to common genetic diseases.
Examples of these markers are: 1  positive family history for the same disease, or for other diseases known to be autoimmune. 2  presence in the same patient of other known autoimmune diseases. 3  presence of infiltrating mononuclear cells in the affected organ or tissue.hen direct and indirect evidence to define an autoimmune disease are not available, investigators are left with circumstantial evidence, that is, with listing markers descriptive of autoimmune disease.