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Agonist. Definition. noun, plural: agonists. (pharmacology) A molecule that combines with a receptor on a cell to trigger physiological reaction. An example is an acetylcholine being the agonist that combines with the cholinergic receptor. (histology) A muscle that contracts while another muscle relaxes, e.g. when bending the elbow the biceps are the agonist.
4. An agonist ties to a receptor site and causes a response whereas an antagonist works against the drug and blocks the response. 5. Agonists are also chemicals or reactions, which help in binding and also altering the function of the activity of receptors.. Agonist and antagonist act in opposite directions. When agonist produces an action, antagonist opposes the action. 2. Agonist works when the muscles relax and antagonist works when muscles contract.