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have been ruled out, a patient is diagnosed with oral leukoplakia. While the long-term history of these. lesions is impossible to predict, it is known that true leukoplakias are considered âpotentially. malignant,â meaning that they have the potential, over time, to develop into oral cancer. Oral leukoplakia occurs in 1-2% of the population and is most common in patients over age 40. It may. affect any part of the mouth.
The actual mechanism of what causes leukoplakia is unknown. However there are certain factors that have been linked with the development of leukoplakia, most of them related with the mouth's reaction to chronic irritation of the mucous membranes. The possible causes of leukoplakia include : Smoking and chewing tobacco.