Re-consent of subjects enrolled in clinical trials initiated prior to March 7, 2012 is not required. From a practical perspective, however, investigators and sponsors may choose to include the required language in consent forms for applicable clinical trials even if study initiation will occur prior to March 7, 2012.
Climate change will have the following effects on Lyme disease: An acceleration of the tick's developmental cycle, a prolonged developmental cycle, increased egg production, increased population density, and a broader range of risk areas.
Left untreated, Lyme disease can cause: 1  Chronic joint inflammation (Lyme arthritis), particularly of the knee. 2  Neurological symptoms, such as facial palsy and neuropathy. 3  Cognitive defects, such as impaired memory.4  Heart rhythm irregularities. 5  Risk factors.6  Preparing for your appointment.eft untreated, Lyme disease can cause: 1  Chronic joint inflammation (Lyme arthritis), particularly of the knee. 2  Neurological symptoms, such as facial palsy and neuropathy. 3  Cognitive defects, such as impaired memory.