Q4. Will the current appraisal forms change as a result of the appraisal data standardization requirements? No. To ease adoption of the new standards, the current appraisal report forms are not being changed. The GSEs are leveraging and re-purposing existing fields to include a standardized response or in some cases, more data points.
Von Willebrand disease (vWD) (/ËfÊnËvÉªlÉ¨brÉËnt/) is the most common hereditary coagulation abnormality described in humans, although it can also be acquired as a result of other medical conditions.he von Willebrand factor is qualitatively normal and genetic testing of the von Willebrand gene and vWF protein reveals no mutational alteration. The defect lies in the qualitatively altered glycoprotein Ib (GPIb) receptor on the platelet membrane which increases its affinity to bind to the von Willebrand factor.
This then reacts with factor III and so on to factor XII. In Von Willebrand's Disease, the dog is missing a substance, which helps the platelets form clots and stabilizes Factor VIII in the clotting process. This substance is called 'Von Willebrand's factor.' Because of the deficient clotting of blood, dogs with Von Willebrand's disease have excessive bleeding upon injury. This would be similar to hemophilia in humans. Certain breeds have a higher incidence of vWD than others.