Macrocytosis - Pathophysiology. 1  The most common cause of macrocytic anemia is megaloblastic anemia, which is the result of impaired DNA synthesis. 2  Vitamin B-12 and folate coenzymes are required for thymidylate and purine synthesis; thus, their deficiency results in retarded DNA synthesis.
(You may want to read the articles about Scales, the Major Scale, or Key Signatures first.) There are 12 different Major Scales: One with no sharps or flats, 4 with sharps, 4 with flats, and 3 with either sharps or flats depending upon enharmonic spelling. Major Scales with no sharps or flats: C Major. Major Scales with sharps: D, E, G, A. Major Scales with flats: E-flat, F, A-flat, B-flat.
and 2 half steps, where the half steps have the maximum separation usually 2 or 3. notes apart. In this paper we will simply consider the major scale, which is one of the diatonic. scales. De nition 1.3. The major scale is a diatonic scale with the pattern of whole step, whole, half, whole, whole, whole, and half. In this paper will also use the notions of interval and triad. Date: AUGUST 21, 2009.