Peritonitis is defined as inflammation of the peritoneum. The inflammatory response involves vasodilation, exudation of protein-rich fluid, cellular infiltration, pain and, chronically, formation of fibrous adhesion. The disease can be classified into primary and secondary cases.
It begins in the venous plexus along the medial side of the foot, and it runs up the medial side of the leg and knee, alongside the saphenous nerve. In the thigh, the long saphenous vein continues up the medial surface, accompanying the medial femoral cutaneous nerve.
The great saphenous vein originates from where the dorsal vein of the big toe (the Hallux) merges with the dorsal venous arch of the foot. After passing in front of the medial malleolus (where it often can be visualized and palpated), it runs up the medial side of the leg.