Macrocytosis - Pathophysiology. 1  The most common cause of macrocytic anemia is megaloblastic anemia, which is the result of impaired DNA synthesis. 2  Vitamin B-12 and folate coenzymes are required for thymidylate and purine synthesis; thus, their deficiency results in retarded DNA synthesis.
(You may want to read the articles about Scales, the Major Scale, or Key Signatures first.) There are 12 different Major Scales: One with no sharps or flats, 4 with sharps, 4 with flats, and 3 with either sharps or flats depending upon enharmonic spelling. Major Scales with no sharps or flats: C Major. Major Scales with sharps: D, E, G, A. Major Scales with flats: E-flat, F, A-flat, B-flat.
This is the complete chromatic scale over two octaves as visualized on the guitar. Scales take their names from the first note played - the C major, C minor, C diminished are all scales that start with C. For historical reasons the major scale and the minor scale consists of seven notes. Other scales may use more than seven notes and some (e.g. pentatonic = 5) less than seven notes.