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have been ruled out, a patient is diagnosed with oral leukoplakia. While the long-term history of these. lesions is impossible to predict, it is known that true leukoplakias are considered âpotentially. malignant,â meaning that they have the potential, over time, to develop into oral cancer. Oral leukoplakia occurs in 1-2% of the population and is most common in patients over age 40. It may. affect any part of the mouth.
Leukoplakia Causes. Reasons for leukoplakia are dependent on what type of leukoplakia â standard or hairy. Standard Leukoplakia. While the cause of leukoplakia is not known, the use of tobacco, including chewing and smoking, seems to be accountable for the majority of cases. 3 out of 4 users of tobacco products regularly will in due course cultivate leukoplakia in the area where the tobacco is held against the cheeks.