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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
Calcium channel blockers prevent calcium from entering cells of the heart and blood vessel walls, resulting in a lower blood pressure. Calcium channel blockers relax and widen blood vessels by affecting the muscle cells in the arterial walls. Some calcium channel blockers have the added benefit of also slowing the heart rate, which can further reduce blood pressure, relieve chest pain (angina), and control an irregular heartbeat.