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Coagulation: Coagulation, in physiology, the process by which a blood clot is formed. The formation of a clot is often referred to as secondary hemostasis, because it forms the second
Freebase(0.00 / 0 votes)Rate this definition: Downregulation and upregulation. Downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external variable. An increase of a cellular component is called upregulation.