So the basic answer to the question how often should I run is three to four days a week with some cross-training thrown in, if possible, and at least one day a week of rest. And one last thing: remember to have some fun, even on those days when your run is on the tougher side.
Effects of berberine in the gastrointestinal tract - a review of actions and therapeutic implications. Berberine is an isoquinoline alkaloid present in several plant species, including Coptis sp. and Berberis sp. In traditional medicine, extracts of berberine are used in the treatment of diarrhea of different origins.
The standard dose of berberine is 900-2,000mg a day, divided into three to four doses. Berberine should be taken with a meal, or shortly after, to take advantage of the blood glucose and lipid spike associated with eating. Too much berberine at once can result in stomach upset, cramping, and diarrhea.