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Coagulation: Coagulation, in physiology, the process by which a blood clot is formed. The formation of a clot is often referred to as secondary hemostasis, because it forms the second
1 Coagulation, which is one part of the body's self-repair mechanism (blood clotting by the platelets after an open wound in order to stop bleeding) 2  Messenger functions, including the transport of hormones and the signaling of tissue damage.  Regulating body pH.