Macrocytosis - Pathophysiology. 1  The most common cause of macrocytic anemia is megaloblastic anemia, which is the result of impaired DNA synthesis. 2  Vitamin B-12 and folate coenzymes are required for thymidylate and purine synthesis; thus, their deficiency results in retarded DNA synthesis.
(You may want to read the articles about Scales, the Major Scale, or Key Signatures first.) There are 12 different Major Scales: One with no sharps or flats, 4 with sharps, 4 with flats, and 3 with either sharps or flats depending upon enharmonic spelling. Major Scales with no sharps or flats: C Major. Major Scales with sharps: D, E, G, A. Major Scales with flats: E-flat, F, A-flat, B-flat.
The thing about scales on the ukulele is that it isnât very practical to play a scale just on one string. The best way to learn scales on the ukulele is to learn them across all the strings and in different positions.There are five positions from where we can play the notes of a C major scale on the fretboard of the ukulele.o in a C major scale, the tonic note of the scale is the note C. There are only twelve major scales because there are only twelve notes in Western music from which we can build a scale. If we know a C major scale like the back of our hand, we can easily modify it later to play the other major scales.