So the basic answer to the question how often should I run is three to four days a week with some cross-training thrown in, if possible, and at least one day a week of rest. And one last thing: remember to have some fun, even on those days when your run is on the tougher side.
Berberine is an alkaloid extracted from various plants used in traditional Chinese medicine. Berberine is supplemented for its anti-inflammatory and anti-diabetic effects. It can also improve intestinal health and lower cholesterol. Berberine is able to reduce glucose production in the liver.
Probably the most important side effects of berberine to note (in my opinion) is that it inhibits the enzyme CYP3A4, a member of the Cytochrome P450 family. What that means is that berberine may decrease how fast the liver breaks down medications.