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1 FACTORS AFFECTING DRUG ABSORPTION List of content :-- I. PHARMACEUTICAL FACTORS A] Chemical factors B] Physicochemical properties of drug substances 1.drug solubility & dissolution rate 2.--Which increases the pH of the diffusion layer, which promotes the solubility and dissolution of a weak acid and absorption is bound to be rapid. ï· Reverse in the case of salts of weak bases, it lowers the pH of diffusion layer and the promoted the absorption of basic drugs.
As there is increase in oral drug absorption of BCS II class drugs, so we can say it is one of the method for enhancing oral bioavailability of drug REFERENCES 1. Wakerly, M.G., et al., Selfâemulsification of veg: oilânonâionic surfactant mixtures, ACS symp.ore consistent temporal profiles of drug absorption 3. Selective drug targeting toward a specific absorption window in the GI tract, and drug protection from the hostile environment in the gut [8, 9]. Drawbacks of SEDDS Includes 1. Chemical instabilities of drugs and high surfactant concentrations.