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The most common Topamax side effects when taken alone by adults with epilepsy are: 1  Tingling of the arms and legs. 2  Weight loss. 3  Sleepiness. A loss of appetite (anorexia) 4  Dizziness. Memory problems.
Common Side Effects in Adults. Topiramate has been studied thoroughly in clinical trials, in which a group of people taking the drug have side effects documented and compared to another group not taking the medicine.