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By Mayo Clinic Staff. Most leg pain results from wear and tear, overuse, or injuries in joints or bones or in muscles, ligaments, tendons or other soft tissues. Some types of leg pain can be traced to problems in your lower spine. Leg pain can also be caused by blood clots, varicose veins or poor circulation.
Leg swelling related to inflammation. Leg swelling can also be caused by inflammation in leg tissues. Inflammation may be a normal response to injury or disease, or it may be due to rheumatoid arthritis or another inflammatory disorder. You will usually feel some pain with inflammation. Factors that can contribute to inflammation in the leg include: