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Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by eliminating mRNA transcripts that contain premature stop codons.If these aberrant mRNA transcripts were translated, the result would be deleterious gain-of-function or dominant-negative activity of the resulting proteins.onsense-mediated decay mutations can also contribute to Marfan syndrome. This disorder is caused by mutations in the fibrillin 1 (FBN1) gene and is resulted from a dominant negative interaction between mutant and wild-type fibrillin-1 gene.
Motor neuron disease (MND) is a serious and incurable form of progressive neurodegeneration-over time the nerves in the spine and brain progressively lose function.In the case of motor neuron disease, motor neurons-types of nerve cells-are affected. If the patient is elderly it may be hard to know whether this is being caused by age or the disease. 2  Dementia-a small proportion of MND patients are diagnosed with dementia. 3  Breathing problems-progressive damage to muscles that control the lungs eventually result in breathing difficulties.