Definition of Speech Impairment. A speech impairment is a condition in which the ability to produce speech sounds that are necessary to communicate with others is impaired. Speech impairments can be mild, such as occasionally mispronouncing a couple of words, to severe, such as not being able to produce speech sounds at all.
methotrexate (Oral route) Only use for life-threatening neoplastic disease or severe rheumatoid arthritis and psoriasis unresponsive to other therapies. Death, fetal death and/or congenital anomalies, lung disease, tumor lysis syndrome, fatal skin reactions, and Pneumocystis carinii pneumonia have been reported.
It remains unclear exactly how methotrexate decreases arthritis activity. 4 - Methotrexate is taken one day a week for arthritis. It is not taken daily like most pills. Methotrexate is available in 2.5 mg tablets. The starting dose for most adults with rheumatoid arthritis is 7.5 to 10 mg (i.e., 3 or 4 pills). The 3 or 4 pills are taken together once a week (i.e., the same day each week). As needed, the dose of methotrexate can be increased to 20 to 25 mg each week.