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Reishi mushroom has been used to help enhance the immune system, reduce stress, improve sleep, and lessen fatigue. People also take reishi mushroom for health conditions such as: High blood pressure
1 High blood pressure. 2  There is inconsistent evidence about the effects of reishi mushroom on high blood pressure. 3  Early research suggests that taking reishi mushroom extract daily for 12 weeks does not lower blood pressure in people with slightly high blood pressure.se of powdered reishi mushroom has been associated with toxic effects on the liver. Reishi mushroom can also cause other side effects including dryness of the mouth, throat, and nasal area along with itchiness, stomach upset, nosebleed, and bloody stools. Drinking reishi wine can cause a rash.