Carthage again went to war with Rome when the general Hannibal attacked the city of Saguntum. Following this war, Carthage became embroiled in what is known as The Mercenary War (241-237 BCE) which started when the Carthaginian army of mercenaries demanded the payment Carthage owed them.
The cause of dermatofibrosarcoma protuberans (DFSP) is unknown. Laboratory studies have shown that chromosomal aberrations may contribute to the pathogenesis of DFSP; however, no evidence of hereditary or familial predisposition exists. In 10-20% of patients with this tumor, trauma at the site seems to be incriminated.
There are at least three different inheritance patterns for chronic pancreatitis (see Causes and contributing risk factors for chronic pancreatitis in children and adolescents, section on 'Genetic'). In addition, cases of pancreatitis without a family history may have a genetic basis (simplex case). âAutosomal dominant hereditary pancreatitis â This is most often associated with mutations in the serine protease 1 gene (PRSS1) on chromosome 7q35, which encodes trypsin-1 (cationic trypsinogen) [1-3].