When used in reference to time, date almost exclusively refers to a specific 24 hour period that begins at midnight and ends at 11:59pm. When used this way, the date will be specified with a year (CE or BCE), the name of the month, and the number of the day within that month.
This medication is used to treat certain types of serious (possibly fatal) irregular heartbeat (such as persistent ventricular fibrillation/tachycardia). It is used to restore normal heart rhythm and maintain a regular, steady heartbeat. Amiodarone is known as an anti-arrhythmic drug.
Pathophysiology. Amiodarone causes a wide spectrum of effects on the thyroid. Amiodarone inhibits type 1 5'-deiodinase enzyme activity, thereby decreasing the peripheral conversion of T4 to triiodothyronine (T3) and reducing the clearance of both T4 and reverse T3 (rT3).