On the one hand, this type of organizational structure benefits from having individuals entirely dedicated to one function. In some cases, there can be cost savings and efficiency gains in combining functions in this way. However, this type of organizational structure is prone to conflict.
The alpha subunit (RpoA) initiates RNAP assembly by dimerising to form a platform on which the beta subunits can interact. The alpha subunit consists of a N-terminal domain (NTD) and a C-terminal domain (CTD), connected by a short linker.
RNA polymerase lacking sigma subunit is called the core RNA polymerase. RNA is synthesized in the 5' to 3' direction (the same direction as DNA is synthesized). The synthesis of RNA does not require a primer, but does require a DNA template strand.he portion of DNA copied is referred to as the template. Like DNA synthesis, transcription proceeds in the 5' to 3' direction. RNA polymerases differ from DNA polymerases in a couple of important respects. First, RNA polymerases do not require a primer.