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Antimicrobial susceptibility testing. Determine vancomycin resistance as well as high-level resistance to penicillin and. aminoglycosides for enterococci isolated from blood, sterile body sites (with the. possible exception of urine), and other sites as clinically indicated. Evaluate the.
At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis.