Definition of Speech Impairment. A speech impairment is a condition in which the ability to produce speech sounds that are necessary to communicate with others is impaired. Speech impairments can be mild, such as occasionally mispronouncing a couple of words, to severe, such as not being able to produce speech sounds at all.
DBLÂ® METHOTREXATE INJECTION AND TABLETS. Name of medicine. Methotrexate BP. Presentation. DBLÂ® Methotrexate Injection is a sterile solution of Me thotrexate BP in Water for Injections BP. Sodium. chloride is included for isotonicity except in the 1 g/10 mL vial. DBL Â® Methotrexate Injection is preservative-.
Drug: F8IL10 in combination with methotrexate. Weekly administration of F8IL10 (from 6 to 600 Î¼g/kg) + MTX (10-15 mg, fixed dose) on Day 1 and Folic acid (5 mg, fixed dose) on Day 2. Patients will receive 4 cycles of 1 week treatment unless there is an unacceptable toxicity or withdrawal of the informed consent. F8IL10 will be administered intravenously. MTX can be administered orally, subcutaneously or intramuscularly. Folic acid will be administered orally.