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4. Synonym: trisomy 13. Patau's syndrome (trisomy 13) carries a high mortality rate with multiple congenital abnormalities which result in severe physical and mental impairment. 1  It is usually due to a free-standing trisomy with an extra number 13 chromosome, instead of the usual pair, in all cells.
Like Patau syndrome, Down syndrome is caused by having an extra copy of a certain chromosome. Individuals with Down syndrome usually have an extra copy of chromosome 21. Thus, Down syndrome is commonly called trisomy 21. Perhaps not surprisingly, the cause of the trisomy in both Patau and Down syndromes is similar. A phenomenon called nondisjunction is responsible for most cases of trisomy 13 and 21.