Definition of Speech Impairment. A speech impairment is a condition in which the ability to produce speech sounds that are necessary to communicate with others is impaired. Speech impairments can be mild, such as occasionally mispronouncing a couple of words, to severe, such as not being able to produce speech sounds at all.
methotrexate (Oral route) Only use for life-threatening neoplastic disease or severe rheumatoid arthritis and psoriasis unresponsive to other therapies. Death, fetal death and/or congenital anomalies, lung disease, tumor lysis syndrome, fatal skin reactions, and Pneumocystis carinii pneumonia have been reported.
Drug: F8IL10 in combination with methotrexate. Weekly administration of F8IL10 (from 6 to 600 Î¼g/kg) + MTX (10-15 mg, fixed dose) on Day 1 and Folic acid (5 mg, fixed dose) on Day 2. Patients will receive 4 cycles of 1 week treatment unless there is an unacceptable toxicity or withdrawal of the informed consent. F8IL10 will be administered intravenously. MTX can be administered orally, subcutaneously or intramuscularly. Folic acid will be administered orally.