A weighted rein refers to a rein that is heavier on one or both ends. Naturally weighted reins are cut from hides that are specifically chosen for their weights and thicknesses. No extra leather or additional materials are added to the them. Notice in the picture the difference in the thicknesses of the tail, center and bit ends of this pair of reins.
Mitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is accomplished by reductive activation of mitomycin to form a mitosene, which reacts successively via N-alkylation of two DNA bases.
Neomycin, an antibiotic, is used to prevent or treat skin infections caused by bacteria. It is not effective against fungal or viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Neomycin comes in cream and ointment that is applied to the skin. Neomycin usually is used one to three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use neomycin exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.