Signs of physical and emotional exhaustion: 1  Chronic fatigue. 2  In the early stages, you may feel a lack energy and feel tired most days. 3  In the latter stages, you feel physically and emotionally exhausted, drained, and depleted, and you may feel a sense of dread for what lies ahead on any given day. 4  Insomnia.
Clinical Trials. Itraconazole is effective and safe in the treatment of vulvovaginal candidiasis 8-15 (see Table 1). Treatment regimens of itraconazole 200mg/day for 3 consecutive days 8,9,11 or 200mg given twice in one day 9,12,14 have resulted in a high mycological and clinical cure.able 1: Studies evaluating the efficacy of itraconazole in the treatment of vulvovaginal candidiasis. Table 2: Studies evaluating the efficacy of itraconazole in the prophylactic treatment of vulvovaginal candidiasis.
Study 1 was a 9-week, fixed dose study involving clonazepam doses of 0.5 mg/day, 1 mg/day, 2 mg/day, 3 mg/day or 4 mg/day or placebo. This study was conducted in four phases: a 1-week placebo lead-in, a 3-week upward titration, a 6-week fixed dose and a 7-week discontinuance phase.