Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
A low white blood cell count, or leukopenia, is a decrease in disease-fighting cells (leukocytes) circulating in your blood. The threshold for a low white blood cell count varies from one medical practice to another.Some healthy people have white cell counts that are lower than what's considered normal.A count lower than 4,000 white blood cells per microliter of blood is generally considered a low white blood cell count. The threshold for a low white blood cell count in children varies with age and sex.he threshold for a low white blood cell count varies from one medical practice to another. Some healthy people have white cell counts that are lower than what's considered normal. A count lower than 4,000 white blood cells per microliter of blood is generally considered a low white blood cell count.