Carthage again went to war with Rome when the general Hannibal attacked the city of Saguntum. Following this war, Carthage became embroiled in what is known as The Mercenary War (241-237 BCE) which started when the Carthaginian army of mercenaries demanded the payment Carthage owed them.
The cause of dermatofibrosarcoma protuberans (DFSP) is unknown. Laboratory studies have shown that chromosomal aberrations may contribute to the pathogenesis of DFSP; however, no evidence of hereditary or familial predisposition exists. In 10-20% of patients with this tumor, trauma at the site seems to be incriminated.
Dystrophic epidermolysis bullosa is an inherited variant affecting the skin and other organs. Butterfly children is the term given to those born with the disease, as their skin is seen to be as delicate and fragile as a butterfly's wings. Dystrophic epidermolysis bullosa is caused by genetic defects (or mutations) within the human COL7A1 gene encoding the protein type VII collagen (collagen VII). DEB-causing mutations can be either autosomal dominant or autosomal recessive.