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1 FACTORS AFFECTING DRUG ABSORPTION List of content :-- I. PHARMACEUTICAL FACTORS A] Chemical factors B] Physicochemical properties of drug substances 1.drug solubility & dissolution rate 2.--Which increases the pH of the diffusion layer, which promotes the solubility and dissolution of a weak acid and absorption is bound to be rapid. ï· Reverse in the case of salts of weak bases, it lowers the pH of diffusion layer and the promoted the absorption of basic drugs.
The rate and extent of drug loss from the human oral cavity can be measured using several different methods. These include the buccal absorption test (Beckett and Triggs, 1967), disc methods (Kaaber, 1974; Schurr and Ziegler, 1983; Pimlott and Addy, 1985) and perfusion cells (Barsuhn et al., 1988, Rathbone, 1990).n appropriate kinetic model to describe the transfer of drugs across oral cavity membranes is problematic (Beckett et al., 1968; Beckett and Moffat, 1970; Beckett and Pickup, 1975; Dearden and Tomlinson, 1971a; Schurmann and Turner, 1978).