Estradiol, or more precisely, 17Î²-estradiol, is a steroid and estrogen sex hormone, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles.stradiol, or more precisely, 17Î²-estradiol, is a steroid and estrogen sex hormone, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles.
Submit. Apples originated in Asia and were first cultivated in the Tien Shan mountains of eastern Kazakhstan. Researchers estimate that this occurred around 8,000 B.C., and that apple cultivation spread along the famous Silk Road trade route to far points east.Keywords: apple, originate, Asia.ocated in Jacksonville, Fla, Frank Whittemore has been a writer and content strategist for over 15 years, providing corporate communications services to Fortune 500 companies. Whittemore writes on topics that stem from his fascination with nature, the environment, science, medicine and technology.
Origin. 'The apple of my eye' is exceedingly old and first appears in Old English in a work attributed to King Aelfred (the Great) of Wessex, AD 885, titled Gregory's Pastoral Care.he phrase was known from those early sources but became more widely used in the general population when Sir Walter Scott included it in the popular novel Old Mortality, 1816: Poor Richard was to me as an eldest son, the apple of my eye.. See also-phrases coined by Sir Walter Scott.