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Antimicrobial susceptibility testing. Determine vancomycin resistance as well as high-level resistance to penicillin and. aminoglycosides for enterococci isolated from blood, sterile body sites (with the. possible exception of urine), and other sites as clinically indicated. Evaluate the.
Vancomycin is bactericidal and appears to bind to the bacterial cell wall causing blockage of glycopeptide polymerization. This effect, which occurs at a site different from that affected by the penicillins, produces immediate inhibition of cell wall synthesis and secondary damage to the cytoplasmic membrane.