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By Mayo Clinic Staff. Most leg pain results from wear and tear, overuse, or injuries in joints or bones or in muscles, ligaments, tendons or other soft tissues. Some types of leg pain can be traced to problems in your lower spine. Leg pain can also be caused by blood clots, varicose veins or poor circulation.
Cause of leg pain in Polycystic Kidney Disease. Muscle cramps and leg pain are common for those with kidney disease, especially when kidney function is impaired. Cramps and leg pain are thought to be caused by imbalances in fluid and electrolytes, but may also be caused by nerve damage or blood flow problems.