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Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP 1), as well as CRTH2 (DP 2).t is a major prostaglandin produced by mast cells â recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD 2 are found only in the brain and in mast cells.