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The most common Topamax side effects when taken with other medicines by children with epilepsy are: 1  Fatigue. 2  Sleepiness. 3  Lack of appetite (anorexia) 4  Nervousness. Problems concentrating or paying attention.  Memory 1  problems. Aggressiveness.  Weight loss.
Rating Newest Oldest. Best Answer: Topamax (topiramate) is an antiepileptic (AED) and anti-migraine drug that is well known to cause weight loss in some patients. Typically weight loss is minimal and it is heavily dose dependent (ie a larger dose causes more weight loss and anorexia (loss of appetite)).