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3. Low serum chloride suggests an electrolyte derangement. 4. Low anti-nuclear antibodies: Anti-nuclear antibodies are raised in connective tissue disorders eg systemic lupus erythematosus. However, a negative value rules out this possibility.
Numerous conditions or factors can cause decreased serum sodium and chloride levels. According to the University of Maryland Medical Center, electrolytes, including sodium and chloride, are minerals in your blood and other body fluids that possess an electric charge.