Definition of Speech Impairment. A speech impairment is a condition in which the ability to produce speech sounds that are necessary to communicate with others is impaired. Speech impairments can be mild, such as occasionally mispronouncing a couple of words, to severe, such as not being able to produce speech sounds at all.
methotrexate (Oral route) Only use for life-threatening neoplastic disease or severe rheumatoid arthritis and psoriasis unresponsive to other therapies. Death, fetal death and/or congenital anomalies, lung disease, tumor lysis syndrome, fatal skin reactions, and Pneumocystis carinii pneumonia have been reported.
With high-dose methotrexate, the primary focus is on an upper limit â toxicity, the drug's effect on the kidney, liver, and blood cell counts, and on unacceptable side effects. Test results are used to guide the amount and timing of leucovorin (folinic acid) given as a rescue treatment.