Meta analyses are only as good as the quality of the underlying studies, which in this case is not very good. Some studies published in quality journals suggest that berberine's positive effects may stem from the fact that it activates AMP-Kinase, which is what metformin does.
Figure 34-2 Medial thigh furrow (wide line) is surface depression extending from proximal anterior to distal posterior thigh. Furrow divides area into medial thigh (proximal) and medial knee (distal). Figure 34-3 Full view of medial thigh/knee contour drawings. A, Right medial thigh, with patient standing and raising left thigh. This view demonstrates medial thigh furrow. B, Left medial thigh, with patient standing and raising right thigh.
a shallow depression, or furrow on the surface of an organ, such as cerebral sulcus that separates the convolutions of the cerebral hemisphere. A sulcus is usually not as deep as a fissure, but, in the terminology of anatomy, the words sulcus and fissure are often used interchangeably.ulcus (sulÂ´kÉs) , n 1. a furrow, trench, or groove, as on the surface of the brain or in the folds of mucous membranes. 2. a groove or depression on the surface of a tooth. 3. a groove in a portion of the oral cavity.