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Antibiotics for Ear Infections: An Overview Many antibiotics are approved by the Food and Drug Administration (FDA) to fight otitis media (ear infections), although most doctors rely on a few favorites. Most antibiotics for ear infections fall under four families:  penicillins, cephalosporins, sulfonamides, and erythromycins. Amoxicillin is the most common antibiotic used to treat ear infections. When using antibiotics for ear infections, remember to take each dose on schedule.
Erythromycin/sulfisoxazole is a combination antibiotic used to treat middle ear infections in children. This product contains a macrolide (erythromycin) and a sulfa-type (sulfisoxazole) antibiotic. It works by stopping the growth of bacteria. This antibiotic combination treats only bacterial infections. It will not work for viral infections (such as common cold, flu).