I have a comment for the Knowledge Base. 1  Fill out this form to submit your comment to the IU Knowledge Base.  If you are affiliated with Indiana University and need help with a computing problem, please use the I need help with a computing problem section above, or contact your campus Support Center.
By Mayo Clinic Staff. Most leg pain results from wear and tear, overuse, or injuries in joints or bones or in muscles, ligaments, tendons or other soft tissues. Some types of leg pain can be traced to problems in your lower spine. Leg pain can also be caused by blood clots, varicose veins or poor circulation.
There are a wide variety of conditions that can cause thigh pain. For example, thigh pain can be caused by physical activity, injury, or age-related wear and tear on the hips and knees, which may cause pain or discomfort in the thigh area near the joint.nfectious causes of thigh pain. Thigh pain can be caused by various infections including: Cellulitis (invasive infection of the skin and surrounding tissues). Infection of a wound or sore. Infection of the knee or hip, which can lead to septic arthritis and cause pain in the joint that radiates to the thigh area.