Meta analyses are only as good as the quality of the underlying studies, which in this case is not very good. Some studies published in quality journals suggest that berberine's positive effects may stem from the fact that it activates AMP-Kinase, which is what metformin does.
Figure 34-2 Medial thigh furrow (wide line) is surface depression extending from proximal anterior to distal posterior thigh. Furrow divides area into medial thigh (proximal) and medial knee (distal). Figure 34-3 Full view of medial thigh/knee contour drawings. A, Right medial thigh, with patient standing and raising left thigh. This view demonstrates medial thigh furrow. B, Left medial thigh, with patient standing and raising right thigh.
Linear or longitudinal furrows are mucosal grooves that run parallel to the long axis of the esophagus (Fig. 1c) and white plaques or exudates can coat the esophagus (Fig. 1d) and may mimic the appearance of candida. In some cases the mucosa appears pale, congested, or has decreased vascularity (Fig.ypical endoscopic findings in eosinophilic esophagitis. (a) Fixed esophageal rings, previously termed corrugation or trachealization. (b) Transient esophageal rings, previously termed felinization. (c) Linear furrows, as well as mucosal pallor, congestion, and loss of vascularity.