Meta analyses are only as good as the quality of the underlying studies, which in this case is not very good. Some studies published in quality journals suggest that berberine's positive effects may stem from the fact that it activates AMP-Kinase, which is what metformin does.
Figure 34-2 Medial thigh furrow (wide line) is surface depression extending from proximal anterior to distal posterior thigh. Furrow divides area into medial thigh (proximal) and medial knee (distal). Figure 34-3 Full view of medial thigh/knee contour drawings. A, Right medial thigh, with patient standing and raising left thigh. This view demonstrates medial thigh furrow. B, Left medial thigh, with patient standing and raising right thigh.
A furrow is a groove or a depression. Originally, furrows were created in soil for water to flow. Now, its most common meaning is of a deep line or wrinkle on the face, as in a furrowed brow.. Furrow is related to the old English word farrow, meaning to root like a swine, which makes sense, seeing as both acts create trenches in the earth. Sometimes a furrow simply means the impression left by a cart wheel or tire track in the mud.