Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
A low white blood cell (WBC) count is a decreased number of white blood cells (leukocytes) in the blood. A low WBC count is referred to medically as leukopenia.WBCs, which are produced in the bone marrow, are an important part of your immune system and your bodyâs natural weapon to fight off bacteria, viruses and other germs. low WBC count is referred to medically as leukopenia. WBCs, which are produced in the bone marrow, are an important part of your immune system and your bodyâs natural weapon to fight off bacteria, viruses and other germs.