A weighted rein refers to a rein that is heavier on one or both ends. Naturally weighted reins are cut from hides that are specifically chosen for their weights and thicknesses. No extra leather or additional materials are added to the them. Notice in the picture the difference in the thicknesses of the tail, center and bit ends of this pair of reins.
Mitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is accomplished by reductive activation of mitomycin to form a mitosene, which reacts successively via N-alkylation of two DNA bases.
Mitomycin is a chemotherapy drug | used to treat different cancers including breast | , bladder | , gullet (oesophagus) | , stomach | , pancreas | , lung | and liver | cancers. Mitomycin can be given directly into the bladder to treat non-invasive bladder cancer. This is called intravesical treatment. This information does not cover when mitomycin is given into the bladder. You can read more about this in our section about treating non-invasive bladder cancer | .