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Difference Between Autism and Down Syndrome. Autism and Down syndrome are well known causes of mental retardation. There are other causes of mental retardation, as well. However, these two are important because Down syndrome represents the pure genetic end of the spectrum while autism represents the purely psychological end. Even though some studies have suggested a genetic link to autism, it remains very doubtful to this date.
Answer   The symptoms, characteristics and outcomes of these two conditions are quite different. Down syndrome is a developmental disorder. Rett syndrome is classified mo â¦ re specifically as a pervasive developmental disorder. A child with Down syndrome can also have a pervasive developmental disorder.