Carthage again went to war with Rome when the general Hannibal attacked the city of Saguntum. Following this war, Carthage became embroiled in what is known as The Mercenary War (241-237 BCE) which started when the Carthaginian army of mercenaries demanded the payment Carthage owed them.
The cause of dermatofibrosarcoma protuberans (DFSP) is unknown. Laboratory studies have shown that chromosomal aberrations may contribute to the pathogenesis of DFSP; however, no evidence of hereditary or familial predisposition exists. In 10-20% of patients with this tumor, trauma at the site seems to be incriminated.
The patient's family history is also considered when determining a diagnosis due to the genetic mode of inheritance of Retinitis Pigmentosa. 1  At least 35 different genes or loci are known to cause nonsyndromic RP (RP that is not the result of another disease or part of a wider syndrome).