Although aminoglycoside-induced nephrotoxicity is generally reversible following discontinuation of the drug, death from uremia has occurred rarely. Therapy with aminoglycosides should be administered cautiously at reduced dosages in patients with renal impairment, since they may be at increased risk for oto- and nephrotoxicity due to drug accumulation.
â Paul Wesley. Paul Thomas Wesley (Polish: PaweÅ Tomasz Wasilewski, born July 23, 1982) is a Polish-American actor who plays Stefan Salvatore, Tom Avery, Silas and Ambrose on The Vampire Diaries. He appeared on several TV shows such as The Guiding Light, Wolf Lake, Smallville, and Everwood.
John Wesley is known for two things: co-founding Methodism and his tremendous work ethic. In the 1700s, when land travel was by walking, horseback or carriage, Wesley logged more than 4,000 miles a year.