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1 FACTORS AFFECTING DRUG ABSORPTION List of content :-- I. PHARMACEUTICAL FACTORS A] Chemical factors B] Physicochemical properties of drug substances 1.drug solubility & dissolution rate 2.--Which increases the pH of the diffusion layer, which promotes the solubility and dissolution of a weak acid and absorption is bound to be rapid. ï· Reverse in the case of salts of weak bases, it lowers the pH of diffusion layer and the promoted the absorption of basic drugs.
permeable to polar molecules and ions, which is discussed below.) All in all, relatively few kinds of endogenous molecules cross membranes by lipid diffusion. However, most drugs are small amphipathic compounds, and therefore rely. heavily on lipid diffusion to move through different compartments in the body. The ability of drugs to diffuse across membranes is heavily inï¬uenced by the. ionizability of the drug in the surrounding medium. The pH of body compartments inï¬uences lipid diffusion of drugs.