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Antibiotics for Ear Infections: An Overview Many antibiotics are approved by the Food and Drug Administration (FDA) to fight otitis media (ear infections), although most doctors rely on a few favorites. Most antibiotics for ear infections fall under four families:  penicillins, cephalosporins, sulfonamides, and erythromycins. Amoxicillin is the most common antibiotic used to treat ear infections. When using antibiotics for ear infections, remember to take each dose on schedule.
Cipro HC is an antibiotic ear drop approved to treat an outer ear infection by killing the bacteria that cause it. Specifically, it is indicated to treat outer ear infections caused by the bacteria Pseudomonas aeruginosa, Staphylococcus aureus, or Proteus mirabilis.