Although aminoglycoside-induced nephrotoxicity is generally reversible following discontinuation of the drug, death from uremia has occurred rarely. Therapy with aminoglycosides should be administered cautiously at reduced dosages in patients with renal impairment, since they may be at increased risk for oto- and nephrotoxicity due to drug accumulation.
â Paul Wesley. Paul Thomas Wesley (Polish: PaweÅ Tomasz Wasilewski, born July 23, 1982) is a Polish-American actor who plays Stefan Salvatore, Tom Avery, Silas and Ambrose on The Vampire Diaries. He appeared on several TV shows such as The Guiding Light, Wolf Lake, Smallville, and Everwood.
William Wilberforce: The Persevering Parliamentarian. In one of the last letters of his life, 87-year-old John Wesley, founder of Methodism, wrote to a young member of Englandâs parliament: âUnless God has raised you up for this very thing, you will be worn out by the opposition of men and devils.