The processing requirements include successful completion of: 1  The application process, which includes a background and polygraph examination, a medical examination, a physical fitness evaluation, and a written examination; 2  24-26 weeks of intensive Academy training.
The cell membrane, being exposed to the outside environment, is an important site of cell-cell communication. As such, a large variety of protein receptors and identification proteins, such as antigens, are present on the surface of the membrane.
The Notch protein spans the cell membrane, with part of it inside and part outside. Ligand proteins binding to the extracellular domain induce proteolytic cleavage and release of the intracellular domain, which enters the cell nucleus to modify gene expression.odulators of the Notch signal, e.g., the Numb protein are able to antagonize Notch effects, resulting in the halting of cell cycle and differentiation of NPCs. In this way, Notch signaling controls NPC self-renewal as well as cell fate specification.