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Antibiotics for Ear Infections: An Overview Many antibiotics are approved by the Food and Drug Administration (FDA) to fight otitis media (ear infections), although most doctors rely on a few favorites. Most antibiotics for ear infections fall under four families:  penicillins, cephalosporins, sulfonamides, and erythromycins. Amoxicillin is the most common antibiotic used to treat ear infections. When using antibiotics for ear infections, remember to take each dose on schedule.
Antibiotics are strong medicines that can kill bacteria. For ear infections, doctors often prescribe oral antibiotics that you swallow in pill or liquid form. However, eardrops can sometimes be safer and more effective than oral medicines. Oral antibiotics have risks. 1  Oral antibiotics are more likely to cause resistant bacteria outside the ear. Then, in the future, the drugs will not work as well. 2  Antibiotic eardrops kill the bacteria faster and more completely than oral antibiotics. Drops donât go into the bloodstream, so more medicine reaches the infection.