When used in reference to time, date almost exclusively refers to a specific 24 hour period that begins at midnight and ends at 11:59pm. When used this way, the date will be specified with a year (CE or BCE), the name of the month, and the number of the day within that month.
Amiodarone is an antiarrhythmic medication that affects the rhythm of heartbeats. Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart).
Pathophysiology. Amiodarone causes a wide spectrum of effects on the thyroid. Amiodarone inhibits type 1 5'-deiodinase enzyme activity, thereby decreasing the peripheral conversion of T4 to triiodothyronine (T3) and reducing the clearance of both T4 and reverse T3 (rT3).