The main stem of the Bay itself is about 189 miles (304 km) long, from the Susquehanna River in the north to the Atlantic Ocean in the south. At its narrowest point near Annapolis, Maryland, the Bay is 4 miles (6.4 km) wide; at its widest point, near the mouth of the Potomac River, it is 30 miles (50 km) wide.
Patau syndrome. Patau syndrome is a syndrome caused by a chromosomal abnormality, in which some or all of the cells of the body contain extra genetic material from chromosome 13. The extra genetic material disrupts normal development, causing multiple and complex organ defects.
Genetic mutation. PKU is caused by a genetic mutation (change to the DNA) in the human phenylalanine hydroxylase (PAH) gene. There are many different types of mutations that can affect the PAH gene, all of which result in the body not producing a functioning PAH enzyme.