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1 FACTORS AFFECTING DRUG ABSORPTION List of content :-- I. PHARMACEUTICAL FACTORS A] Chemical factors B] Physicochemical properties of drug substances 1.drug solubility & dissolution rate 2.--Which increases the pH of the diffusion layer, which promotes the solubility and dissolution of a weak acid and absorption is bound to be rapid. ï· Reverse in the case of salts of weak bases, it lowers the pH of diffusion layer and the promoted the absorption of basic drugs.
The absorption rate of a drug molecule is generally a function of drug absorption through the GIT, which is determined by the residence time and absorption in each GIT segment (Kimura and Higaki 2002).In general, gastric transit time impacts the systemic exposure of rapidly dissolved and well absorbed drugs.ost of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration (Lipinski 1995, Lipinski 2000, Lipinski et al. 2001, Lipinski 2004, Abrahamsson and Lennernas 2005).