Carthage again went to war with Rome when the general Hannibal attacked the city of Saguntum. Following this war, Carthage became embroiled in what is known as The Mercenary War (241-237 BCE) which started when the Carthaginian army of mercenaries demanded the payment Carthage owed them.
The cause of dermatofibrosarcoma protuberans (DFSP) is unknown. Laboratory studies have shown that chromosomal aberrations may contribute to the pathogenesis of DFSP; however, no evidence of hereditary or familial predisposition exists. In 10-20% of patients with this tumor, trauma at the site seems to be incriminated.
Reduced penetrance in some genetic disorders may also depend on genetic background of gene carriers. In Hirschsprung disease (HSCR), although the presence of RET mutations is sufficient to explain HSCR inheritance, a genome scan reveals that new susceptibility locus on 9q-31 is also required to cause the disease [20] .