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Costs for pre-surgical evaluation, anterior temporal lobectomy, and all subsequent follow-up medical care until death were estimated to be $109,362. For only medical management over the same time interval, the estimated cost was $84,276.
Approximately two thirds of patients with temporal lobe epilepsy treated surgically have hippocampal sclerosis as the pathologic substrate. Hippocampal sclerosis involves hippocampal cell loss in the CA1 and CA3 regions and the dentate hilus. The CA2 region is relatively spared.