One of Pavlov's dogs, preserved at The Pavlov Museum, Ryazan, Russia. The concept for which Pavlov is famous is the  conditioned reflex  (or in his own words the conditional reflex) he developed jointly with his assistant Ivan Filippovitch Tolochinov in 1901. He had come to learn this concept of conditioned reflex when examining the rates of salivations among dogs.
There are 110 calories in 1 large Honeycrisp Apple. Calorie breakdown: 3% fat, 96% carbs, 2% protein.
How Many Calories In An Apple. Calories in an Apple (raw with skin) The Calories in an Apple range from approximately 53 calories for an extra small apple (2-12 inch diameter) up to about 116 calories (for a large apple of approximately 3-1/4 inch diameter). The vast majority of the calories in an apple come from carbohydrates.