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1 FACTORS AFFECTING DRUG ABSORPTION List of content :-- I. PHARMACEUTICAL FACTORS A] Chemical factors B] Physicochemical properties of drug substances 1.drug solubility & dissolution rate 2.--Which increases the pH of the diffusion layer, which promotes the solubility and dissolution of a weak acid and absorption is bound to be rapid. ï· Reverse in the case of salts of weak bases, it lowers the pH of diffusion layer and the promoted the absorption of basic drugs.
1 The rate and extent of first-pass intestinal metabolism of a drugafter oral administration are dependent on various physiologicalfactors1. 2  Site of absorption: If the absorption site in the intestine is differentfrom the metabolic site, first-pass intestinal metabolism of a drugmay not be significant.2. â¢ Phase I metabolism is sometimes called a â¢ Phase II metabolism includes what are known âfunctionalization reaction,â as conjugation reactions.â¢ Results in the introduction of new hydrophilic functional groups to compounds.