Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
White blood cells, or WBC, are produced in the bone marrow and are the disease-fighting cells of the body. According to MedLinePlus, a low WBC count, also called leukopenia or neutropenia, is when the concentration of white blood cells in the body are less than 4,500 cells per microliter of blood.hite blood cells, or WBC, are produced in the bone marrow and are the disease-fighting cells of the body. According to MedLinePlus, a low WBC count, also called leukopenia or neutropenia, is when the concentration of white blood cells in the body are less than 4,500 cells per microliter of blood.