Definition of Speech Impairment. A speech impairment is a condition in which the ability to produce speech sounds that are necessary to communicate with others is impaired. Speech impairments can be mild, such as occasionally mispronouncing a couple of words, to severe, such as not being able to produce speech sounds at all.
methotrexate (Oral route) Only use for life-threatening neoplastic disease or severe rheumatoid arthritis and psoriasis unresponsive to other therapies. Death, fetal death and/or congenital anomalies, lung disease, tumor lysis syndrome, fatal skin reactions, and Pneumocystis carinii pneumonia have been reported.
F8IL10 in combination with methotrexate. This study foresees one arm of treatment with several coohorts aimed to increase the dosage of F8IL10. In the study cohorts a fixed dose of MTX (10-15 mg) and increasing doses of F8IL10 (starting from 6 Î¼g/kg cohort 1) will be administered.