The outer circle of stars shall be so arranged that one star shall appear directly in the middle at the top of the circle, and the word Indiana shall be placed in a half circle over and above the star representing Indiana and midway between it and the star in the center above it.
Mutations in either nuclear DNA (nDNA) or mitochondrial DNA (mtDNA) can cause mitochondrial disease. Nuclear DNA is packaged into structures called chromosomesâ22 pairs of non-sex related chromosomes (called autosomes) and a single pair of sex chromosomes (XX in females and XY in males).
Mutations in at least three mitochondrial genes can cause cytochrome c oxidase deficiency (also known as complex IV deficiency), which is a condition that can affect several parts of the body, including the muscles used for movement (skeletal muscles), the heart, the brain, or the liver.