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Antibiotics for Ear Infections: An Overview Many antibiotics are approved by the Food and Drug Administration (FDA) to fight otitis media (ear infections), although most doctors rely on a few favorites. Most antibiotics for ear infections fall under four families:  penicillins, cephalosporins, sulfonamides, and erythromycins. Amoxicillin is the most common antibiotic used to treat ear infections. When using antibiotics for ear infections, remember to take each dose on schedule.
The most common medical treatment for an adult ear infection is the use of antibiotics, according to the New York Times Health Guide. Antibiotics are only effective if the ear infection is the result of a bacterial infection. If symptoms do not improve within three days of starting the antibiotic, patients should tell their doctor. Surgery may be required if the adult ear infection leads to a ruptured ear drum or malfunctioning ear tubes.