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1 FACTORS AFFECTING DRUG ABSORPTION List of content :-- I. PHARMACEUTICAL FACTORS A] Chemical factors B] Physicochemical properties of drug substances 1.drug solubility & dissolution rate 2.--Which increases the pH of the diffusion layer, which promotes the solubility and dissolution of a weak acid and absorption is bound to be rapid. ï· Reverse in the case of salts of weak bases, it lowers the pH of diffusion layer and the promoted the absorption of basic drugs.
It has been shown that the dosage-excretion patterns of vitamins differ. Many factors, most of which are not fully understood, are involved in vitamin absorption. These include mode of administration, pharmaceutical form and size of the dose as well as site of absorption of the vitamin. The size of dose significantly influences the percentage of excretion of thiamine and vitamin B12 but has no effect on that of ascorbic acid, niacinamide or riboflavin.