914-765-0688. 1  Beehive Restaurant, serving Traditional American with a few Mediterranean dishes, is located at 30 Old Route 22, Armonk, NY 10504 in Westchester County. 2  The Cafe at Mariani Gardens is located at 45 Bedford Road in Armonk, NY 10504 in Westchester County.
The Discovery of the lac Operon. In 1961, Francois Jacob and Jacques Monod proposed the operon model of gene regulation in bacteria. The model was based on their study of the genes in E. coli that code for enzymes that affect the breakdown of lactose. Francois Jacob and Jacques Monod. Photo courtesy of Archive Photo. Because of the pioneering work of Jacob and Monod, the lac operon is typically used to illustrate gene regulation in bacteria.
If lactose and glucose are present, the cell will use all of the glucose before the lac operon is turned on. This type of control is termed catabolite repression. To prevent lactose metabolism, a second level of control of gene expression exists. The promoter of the lac operon has two binding sites. One site is the location where RNA polymerase binds. The second location is the binding site for a complex between the catabolite activator protein (CAP) and cyclic AMP (cAMP). The binding of the CAP-cAMP complex to the promoter site is required for transcription of the lac operon.