Meta analyses are only as good as the quality of the underlying studies, which in this case is not very good. Some studies published in quality journals suggest that berberine's positive effects may stem from the fact that it activates AMP-Kinase, which is what metformin does.
Figure 34-2 Medial thigh furrow (wide line) is surface depression extending from proximal anterior to distal posterior thigh. Furrow divides area into medial thigh (proximal) and medial knee (distal). Figure 34-3 Full view of medial thigh/knee contour drawings. A, Right medial thigh, with patient standing and raising left thigh. This view demonstrates medial thigh furrow. B, Left medial thigh, with patient standing and raising right thigh.
Vastus medialis. The vastus medialis muscle is a part of the quadriceps muscle group, located on the front of the thigh. It is the most medial, or inner, of the quadriceps muscles.It extends the entire length of the thigh.The portion of the muscle that is just above the knee is sometimes referred to as the vastus medialis obliquus, or VMO. This muscle is used to extend the leg at the knee and to stabilize the patella, which is also known as the kneecap.t extends the entire length of the thigh. The portion of the muscle that is just above the knee is sometimes referred to as the vastus medialis obliquus, or VMO. This muscle is used to extend the leg at the knee and to stabilize the patella, which is also known as the kneecap.