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Among all causes of hypercalcemia, primary hyperparathyroidism and malignancy are the most common, accounting for greater than 90 percent of cases (table 1). This topic card will review the etiology of hypercalcemia. The clinical manifestations, diagnostic approach, and treatment are reviewed separately.
Hypercalcemia is an electrolyte imbalance and is indicated by an excess of calcium in the blood. The normal adult value for calcium is 4.5-5.5 mEq/L. There are many reasons for an elevated blood calcium level. Cancer that started in the bone, or cancer that has spread to the bone.