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Making the world better, one answer at a time. Zyrtec (cetirizine) is classified as a second generation antihistamine. It is believed to antagonize peripheral H1 receptors and not cross the blood brain barrier (this is why it is less drowsy then other antihistamines).The side effects of Zyrtec such as dry mouth may suggest that it does have some anticholinergic properties.owever, despite the claims of minimal muscarinic receptor activity, anticholinergic side effects may still occur with venlafaxine. 14 people found this useful. 1  Allergy Medications: Zyrtec Versus Claritin Zyrtec versus Claritin is more a matter of the side effects of both drugs versus their effects on allergies.
Yes: Similarity: in the 2nd generation antihistamine class of drugs. Zyrtec and Claritin are safe in pregnancy. Both can cause dryness and urinary symptoms as a sideffect differences: Claritin does not usually cause drowsiness.Zyrtec typically can.laritin, brand of Loratadine and zyrtec, brand of Cetirizine are both 2nd generation, non-sedating antihistamines. Cetirizine in head to head studies with Loratadine was found to be more effective for nasal allergies and hives.