A weighted rein refers to a rein that is heavier on one or both ends. Naturally weighted reins are cut from hides that are specifically chosen for their weights and thicknesses. No extra leather or additional materials are added to the them. Notice in the picture the difference in the thicknesses of the tail, center and bit ends of this pair of reins.
Mitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is accomplished by reductive activation of mitomycin to form a mitosene, which reacts successively via N-alkylation of two DNA bases.
Mutamycin (mitomycin) for Injection is an antibiotic that acts as an antineoplastic (anticancer) medication used to treat cancer of the stomach and pancreas. The brand name of this medication is discontinued, but generic versions may be available. Common side effects include nausea and vomiting (may be severe), stomach/abdominal pain, or loss of appetite. Temporary hair loss may occur.