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Inflammation may result in organ damage. Blood clotting during sepsis reduces blood flow to limbs and internal organs, depriving them of nutrients and oxygen. In severe cases, one or more organs fail. In the worst cases, infection leads to a life-threatening drop in blood pressure, called septic shock.
Hemostasis is the body's way of stopping injured blood vessels from bleeding. Hemostasis includes clotting of the blood. Too much clotting can block blood vessels that are not bleeding. Consequently, the body has control mechanisms to limit clotting and dissolve clots that are no longer needed. An abnormality in any part of the system that controls bleeding can lead to excessive bleeding or excessive clotting, both of which can be dangerous.