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The most common Topamax side effects when taken alone by adults with epilepsy are: 1  Tingling of the arms and legs. 2  Weight loss. 3  Sleepiness. A loss of appetite (anorexia) 4  Dizziness. Memory problems.
A few people do experience psychiatric disorders when they take Topamax. If you notice any of these problems, call the doctor's office. Sometimes the doctor can help by changing the amount of Topamax you take or how you take it. Don't stop taking Topamax or change the amount you take without the doctor's guidance.