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Bullous pemphigoid. Bullous pemphigoid is an acute or chronic autoimmune skin disease, involving the formation of blisters, more appropriately known as bullae, at the space between the epidermis and dermis skin layers. It is classified as a type II hypersensitivity reaction, with the formation of anti-hemidesmosome antibodies.
About Your Diagnosis. Bullous pemphigoid is a chronic bullous disease of the skin and mucous membranes. It typically begins as an eruption of red wheals (urticarial lesions) and evolves over weeks to months to bullae (large blisters).