Johnson (1990) also combined heuristic orderings LE and LD, but he considered them simultaneously through the simple linear combination of LD, with LE multiplied by a weighted factor wLE that was varied.
Although most authorities agree on an extended course of therapy, considerable controversy surrounds the optimal target therapeutic INR for patients with antiphospholipid syndrome. For an initial venous thromboembolic event, a target INR of 2.0 to 3.0 is supported by two prospective, randomized clinical trials.lthough most authorities agree on an extended course of therapy, considerable controversy surrounds the optimal target therapeutic INR for patients with antiphospholipid syndrome. For an initial venous thromboembolic event, a target INR of 2.0 to 3.0 is supported by two prospective, randomized clinical trials.
Anti-phospholipid Antibody Testing (Lupus Anticoagulant Testing) Background Information Anti-phospholipid syndrome (APS) is the most common cause of acquired thrombophilia, and the presence of antiphospholipid antibody (APA) is associated with significant morbidity and mortality across diverse patient populations.