Johnson (1990) also combined heuristic orderings LE and LD, but he considered them simultaneously through the simple linear combination of LD, with LE multiplied by a weighted factor wLE that was varied.
Although most authorities agree on an extended course of therapy, considerable controversy surrounds the optimal target therapeutic INR for patients with antiphospholipid syndrome. For an initial venous thromboembolic event, a target INR of 2.0 to 3.0 is supported by two prospective, randomized clinical trials.lthough most authorities agree on an extended course of therapy, considerable controversy surrounds the optimal target therapeutic INR for patients with antiphospholipid syndrome. For an initial venous thromboembolic event, a target INR of 2.0 to 3.0 is supported by two prospective, randomized clinical trials.
Anti-Cyclic Citrullinated Peptide Antibody Test (anti-CCP) - Anti-CCP is a blood test which is now commonly ordered if rheumatoid arthritis is suspected. A moderate to high level of anti-CCP in blood essentially confirms the diagnosis in a person who has clinical signs of rheumatoid arthritis. The anti-CCP test is more specific than the test for rheumatoid factor. In clinical practice, both the rheumatoid factor test and anti-CCP test should be ordered together.