An average subdivision of 200 homes (with four people per house) generates about 3,270 kg of total N per square kilometer (1 square kilometer has about 247 acres) each year [= 200 homes x 4 people x 11.2 grams total N per day x 365 days in a year].ikewise, assuming a fertilizer application rate of 40 â 80 kg total N per acre per year for agricultural crops, fertilizer can add 10,000 â 20,000 kg of total N in 1 square kilometer (247 acres).
A Answers (1) Follow Following Unfollow Pending Disabled. A RealAge answered. Opdivo (nivolumab) is a drug approved for use in fighting advanced kidney cancer, advanced non-small cell lung cancer, and inoperable or advanced melanoma skin cancer. It is an intravenous drug, infused over an hour. Dosage varies according to the type of cancer treated, and may be prescribed with other drugs.
The most common adverse reactions (reported in at least 20% of OPDIVO-treated patients) were fatigue, diarrhea, rash, musculoskeletal pain, pruritus, headache, nausea, upper respiratory infection, and abdominal pain.