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What is Hyper IgE syndrome? Hyper IgE syndrome (HIES) is also known as Job's syndrome. It is a primary immunodeficiency where recurrent skin boils, eczema and pneumonia are seen. What are the symptoms of Hyper IgE syndrome? Symptoms of Job's syndrome include eczema, recurrent abscesses, pneumonia and recurrent candida infections. Eczema usually occurs in the creases behind the ears, the back, buttocks and scalp. Boils and abscesses are commonly caused by bacteria called as staphylococcal aureus.
Unconjugated Hyperbilirubinemia. Key Points: â¢ Gilbertâs Syndrome is an inherited defect in the UDP-glucuroonosyltransferase enzyme resulting. in unconjugated hyperbilirubinemia (levels near 3 mg/dL) â¢ Diagnosis is clinical: elevated indirect bili, normal CBC/smear/retics, and normal LFTâs. â¢ Crigler-Najjer Types I and II are rare inherited defects in the same enzyme resulting in. markedly elevated indirect bilis and potentially kernicterus (type I)