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Guaifenesin is used to control cough and is sometimes combined with dextromethorphan, an antitussive (cough medicine), such as in Mucinex DM or Robitussin DM. Side-effects. Side-effects of guaifenesin include nausea, vomiting, formation of kidney stones, diarrhea, and constipation. Nausea and vomiting can be reduced by taking guaifenesin with meals. The risk of forming kidney stones during prolonged use can be reduced by maintaining good hydration and increasing the pH of urine.
We have all seen the commercials for Mucinex: Mr. Mucus losing the battle to Mucinex, resulting in his eviction from the nose. Yes, this stuff really works, if used as directed, which is 2 pills, twice a day, with plenty of water. Guaifenesin works by increasing the water content of your mucus, making it thin and easier to clear out. Mucinex contains time-released guaifenesin, so it only has to be taken every 12 hours. The generics also work, but not when taken twice a day. Walgreen's Mucus Relief contains immediate-release guaifenesin, and should be taken 1 pill every 4 hours.