Iatrogenic Cushing Syndrome - Background. 1  Cushing syndrome, first described by Harvey in 1912, refers to signs and symptoms caused by excess free plasma glucocorticoids. Excess glucocorticoids can be from increased endogenous production or prolonged exposure to exogenous use of glucocorticoid products. While endogenous Cushingâs syndrome is a rare disease, iatrogenic (drug-related or exogenous) Cushing syndrome from glucocorticoid products is commonly seen in clinical practice. This article will focuses on iatrogenic, or drug-related, Cushing syndrome. Drugs that have been reported to result in hypercortisolism are glucocorticoids, megestrol acetate, and herbal preparations that contain glucocorticoids.
Specific IgE (allergy) tests. IgE-mediated allergy usually presents with symptoms of immediate hypersensitivity within a short period of allergen exposure. Clinical features may include one or more of itching, urticaria, angioedema, conjunctivitis, rhinitis, wheezing, stridor or hypotension.pecific IgE testing is used when skin prick tests are unavailable, the patient cannot stop taking anti-histamines, in the presence of extensive eczema, or with severe anaphylaxis where there is a concern about the risk of systemic symptoms with skin prick testing.
Because IgE antibodies are unique to each allergen (for example, IgE produced in response to pollen differs from IgE produced after a bee sting), checking for specific variants in the blood can help determine if an allergy is present.