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What happens if I overdose (Depakote, Depakote ER, Depakote Sprinkles)? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include sleepiness or drowsiness, shallow breathing, weak pulse, or loss of consciousness. Drinking alcohol can increase certain side effects of divalproex sodium. Divalproex sodium may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid exposure to sunlight or tanning beds.
â¢ Most clinicians dose Depakote at bedtime in order to increase compliance and minimize side effects, regardless of the formulation used. â¢ Start at 250-500 mg QHS, gradually increasing to achieve a blood Depakote level of 70-80 mcg/mL, which will often be in the 1000-1250 mg QHS range. â¢ When converting from regular Depakote to Depakote ER, be aware that patients will see about 20% less. valproic acid with the ER formulation, making converting somewhat tricky, given that Depakote ER only. comes in the 500 mg option.