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What is Hyper IgE syndrome? Hyper IgE syndrome (HIES) is also known as Job's syndrome. It is a primary immunodeficiency where recurrent skin boils, eczema and pneumonia are seen. What are the symptoms of Hyper IgE syndrome? Symptoms of Job's syndrome include eczema, recurrent abscesses, pneumonia and recurrent candida infections. Eczema usually occurs in the creases behind the ears, the back, buttocks and scalp. Boils and abscesses are commonly caused by bacteria called as staphylococcal aureus.
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test. Immunoglobulin E (IgE) is one of the 5 classes of immunoglobulins, and is defined by the presence of the epsilon heavy chain.It is the most recently described immunoglobulin, having first been identified in 1966.he function of IgE is also distinct from other immunoglobulins in that it induces activation of mast cells and basophils through the cell-surface receptor Fc epsilon RI. Fc epsilon RI is a high-affinity receptor specific for IgE present at a high density on tissue-resident mast cells and basophils.