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FLEXERIL tablets contain the following inactive ingredients: hydroxypropyl cellulose, hydroxypropyl methylcellulose, iron oxide, lactose, magnesium stearate, starch, and titanium dioxide. FLEXERIL 5 mg tablets also contain Yellow D&C #10 Aluminum Lake HT, and Yellow FD&C #6 Aluminum Lake. CLINICAL PHARMACOLOGY Cyclobenzaprine HCl relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to central nervous system disease.
It is highly bound to plasma proteins and is extensively distributed throughout various bodily tissues including the small intestine, lungs, kidneys, and liver. When administered consistently three times per day (t.i.d.), Flexeril accumulates to reach steady state concentrations within 72 to 96 hours (3 to 4 days).