The blood clotting system or coagulation pathway, like the complement system, is a proteolytic cascade. Each enzyme of the pathway is present in the plasma as a zymogen (inactive form), which on activation undergoes proteolytic cleavage to release the active factor from the precursor molecule. The coagulation pathway functions as a series of positive and negative feedback loops which control the activation process.
Spring Yard Zone is the third Zone in the original Sonic the Hedgehog. It is an urban level with many springs and bumpers, resembling a pinball machine. There are many secret areas in this zone. Act 2 has two Robotnik signs (goals) and as such, can be ended through two possible routes.
For an established yard, lime may be used at any time, but is best applied, in order, during fall, winter and spring. Using a spreader to apply lime ensures more even application and better distribution.