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Telomere Definition. Telomeres are short tandem repeats of nucleotides at the ends of chromosomes. Let's break this definition down a bit. Nucleotides are the building blocks of DNA, which is the carrier of genetic information.
Telomerase replaces short bits of DNA known as telomeres, which are otherwise shortened when a cell divides via mitosis. In normal circumstances, absent telomerase, if a cell divides recursively, at some point the progeny reach their Hayflick limit, which is believed to be between 50â70 cell divisions.elomerase is a reverse transcriptase enzyme that carries its own RNA molecule (with the pattern of  C C C A A U C C C  in vertebrates), which is used as a template when it elongates telomeres.