Dosing Considerations. Contraindicated with concomitant use of an ACE inhibitor; if switching from an ACE inhibitor to sacubitril/valsartan, allow a washout period of 36 hr between administration of the 2 drugs. Usually administered in conjunction with other heart failure therapies, in place of an ACE inhibitor or other ARB.
A definition is a statement of the meaning of a term (a word, phrase, or other set of symbols).Definitions can be classified into two large categories, intensional definitions (which try to give the essence of a term) and extensional definitions (which list every single object that a term describes). definition states the meaning of a word using other words. This is sometimes challenging. Common dictionaries contain lexical, descriptive definitions, but there are various types of definition-all with different purposes and focuses.
deâ¢noâ¢taâ¢tion. 1. the explicit or direct meaning or set of meanings of a word or expression, as distinguished from the ideas or meanings associated with or suggested by it. Compare connotation (def. 2). 2. the act or fact of denoting; indication. 3. a word that names or denotes something. 4. a mark, sign, or symbol; indicator. 5.