One of these mechanisms involves the reduced availability of an essential nutrient, thiamine, to the brain as a consequence of chronic alcohol consumption. This article describes the normal role of thiamine in brain functioning as well as the pathological consequences that result from thiamine deficiency.
An early interest in the outdoors. Daniel Boone was born near Reading, Pennsylvania, on November 2, 1734, the sixth of eleven children born to Squire Boone, a farmer and land speculator (a person who buys land hoping that it will increase in value and be sold for a profit), and Sarah Morgan.
On 14 August 1756, Daniel Boone and Rebecca Bryan were married in a triple wedding ceremony (three couples were married at the same time.) The ceremony was performed by the father of the groom, Squire Boone, who was a Justice of the Peace at that time.