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There were 273 patients; 140 randomized to diazepam and 133 to lorazepam. INTERVENTIONS: Patients received either 0.2 mg/kg of diazepam or 0.1 mg/kg of lorazepam intravenously, with half this dose repeated at 5 minutes if necessary. If status epilepticus continued at 12 minutes, fosphenytoin was administered.ONCLUSIONS AND RELEVANCE: Among pediatric patients with convulsive status epilepticus, treatment with lorazepam did not result in improved efficacy or safety compared with diazepam. These findings do not support the preferential use of lorazepam for this condition.
There was no difference in the primary efficacy outcome of cessation of status epilepticus for 10 minutes without recurrence within 30 minutes, which occurred in 101 of 140 (72.1%) patients in the diazepam group and 97 of 133 (72.9%) patients in the lorazepam group.here was no difference in the primary efficacy outcome of cessation of status epilepticus for 10 minutes without recurrence within 30 minutes, which occurred in 101 of 140 (72.1%) patients in the diazepam group and 97 of 133 (72.9%) patients in the lorazepam group.