inflammation-a response of body tissues to injury or irritation; characterized by pain and swelling and redness and heat.. redness, swelling, and fever in a local area of the body, often with pain and disturbed function, in reaction to an infection or to a physical or chemical injury. 2. the act or fact of inflaming. 3. the state of being inflamed.
Farthest North- Alaska. Farthest East-This is not easy to answer. On a map of the USA, Maine would seem to be the farthest east.
The farthest spot from a road in the Lower 48 states is less than 30 miles according to this source. If any territory or land area controlled by the US federal government in any capacity qualifies, then the uninhabited Midway Islands, site of the famed WW2 Battle of Midway, are the clear winner.