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Full siblings (full brothers or full sisters; or brother and sister) have the same biological parents and are 50% related (full siblings share 50% of their genes out of those that vary among humans). Identical twins by definition are 100% related.
Legally your kids and your sisterâs kids are first cousins but at the DNA level they are half siblings. They share twice as much DNA as run of the mill first cousins! What I thought Iâd do for the rest of the answer is go into a bit more detail about why you and your sisterâs kids share 25% of their DNA.