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Telomere Definition. Telomeres are short tandem repeats of nucleotides at the ends of chromosomes. Let's break this definition down a bit. Nucleotides are the building blocks of DNA, which is the carrier of genetic information.
Each chromosome is like a DNA library with two protective caps on the end known as telomeres. As telomeres become shorter, their structural integrity weakens, which causes cells to age faster and die younger. In human cells, telomeres are usually single-stranded DNA that contains several thousand repeats of a simple TTAGGG sequence.