Johnson (1990) also combined heuristic orderings LE and LD, but he considered them simultaneously through the simple linear combination of LD, with LE multiplied by a weighted factor wLE that was varied.
Although most authorities agree on an extended course of therapy, considerable controversy surrounds the optimal target therapeutic INR for patients with antiphospholipid syndrome. For an initial venous thromboembolic event, a target INR of 2.0 to 3.0 is supported by two prospective, randomized clinical trials.lthough most authorities agree on an extended course of therapy, considerable controversy surrounds the optimal target therapeutic INR for patients with antiphospholipid syndrome. For an initial venous thromboembolic event, a target INR of 2.0 to 3.0 is supported by two prospective, randomized clinical trials.
There are several kinds of antiphospholipid antibodies. The three most widely measured are lupus anticoagulant, anticardiolipin antibody, and anti-Î² 2 glycoprotein I. These antibodies react with proteins in the blood that are bound to phospholipid, a type of fat molecule that is part of the normal cell membrane.utoantibodies are antibodies that are directed against oneâs self. Antiphospholipid antibodies interfere with the normal function of blood vessels, causing narrowing and irregularity of the vessel (vasculopathy), and by causing blood clots in the vessel (thrombosis).