Transient flushing is also a common side effect of alcohol, particularly in heavy drinkers. It is due to acetaldehyde, the main breakdown product of alcohol. Acetaldehyde is thought to cause flushing by stimulating release of histamine.
The right two lanes of the Tri-State Tollway become exit only for the ramp connection to Interstate 94/Bishop Ford (Calumet) Expressway west (north) to Chicago and Illinois 394/Bishop Ford (Calumet) Expressway south to Crete and Danville. An END Interstate 294 sign is posted on this guide sign.
That tragic honour goes to the so-called Great Tri-State Tornado, which, on 18 March 1925, roared across south-east Missouri, southern Illinois and south-west Indiana, devouring all in its path. Starting at about 1pm northwest of Ellington, Missouri, the tornado finally dissipated near Princeton, Indiana, some three and a half hours and 220 miles later.