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Telomere Definition. Telomeres are short tandem repeats of nucleotides at the ends of chromosomes. Let's break this definition down a bit. Nucleotides are the building blocks of DNA, which is the carrier of genetic information.
Telomeres shorten each time a cell divides and at a certain point, when they reach a critical length, the cell can no longer divide and will die. Their limited lifespan means that growing cells in laboratories can be tricky, given there can only be so many cell doublings before they give up the ghost.