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Telomere Definition. Telomeres are short tandem repeats of nucleotides at the ends of chromosomes. Let's break this definition down a bit. Nucleotides are the building blocks of DNA, which is the carrier of genetic information.
Therefore, telomeres act as the aging clock in every cell. Telomeres are shortened as we age, but telomeres can also be shortened by stress, smoking, obesity, lack of exercise and a poor diet. Short telomeres are connected to premature cellular aging.