Johnson (1990) also combined heuristic orderings LE and LD, but he considered them simultaneously through the simple linear combination of LD, with LE multiplied by a weighted factor wLE that was varied.
Although most authorities agree on an extended course of therapy, considerable controversy surrounds the optimal target therapeutic INR for patients with antiphospholipid syndrome. For an initial venous thromboembolic event, a target INR of 2.0 to 3.0 is supported by two prospective, randomized clinical trials.lthough most authorities agree on an extended course of therapy, considerable controversy surrounds the optimal target therapeutic INR for patients with antiphospholipid syndrome. For an initial venous thromboembolic event, a target INR of 2.0 to 3.0 is supported by two prospective, randomized clinical trials.
Graham Hughes described in 1983 a syndrome, characterized by recurrent arterial and. venous thrombosis, pregnancy morbidity, thrombocytopenia, and the presence of. antiphospholipid antibodies (aPL), which was named antiphospholipid syndrome [Hughes, 1983]. Many other features of this syndrome were identified during the time. In present, antiphospholipid syndrome is considered a systemic form of autoantibody-induced thrombophilia, which involves many organs [Wilson et al., 1999].