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The second definition in JoeBright's answer is correct: thot is an acronym that stands for That Ho Over There.. The word has a negative connotation and is such sometimes used as an affectionate insult to close friends, but is almost always used to describe women.
1 She a thot. 2  He a thot. 3  That bitch a thot. 4  I don't like her cause she a thot. 5  That nigga a thot. 6  She a thot though. 7  That stupid bitch a thot, with her STD infected ass. 8  That bitch sucking dick over there is a thot. 9  That bitch a fucking thot, G. That thot do dicks a lot.10  She a ratchet-ass thot. I used to call people I knew third cause they were but then they caught leukemia from someone's dock and died as a thot a,a stupid,ratchet ass thot that she was. 2  I am a thot and I am also a bitch. 3  See more words with the same meaning: acronyms (list of) .