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What is Hyper IgE syndrome? Hyper IgE syndrome (HIES) is also known as Job's syndrome. It is a primary immunodeficiency where recurrent skin boils, eczema and pneumonia are seen. What are the symptoms of Hyper IgE syndrome? Symptoms of Job's syndrome include eczema, recurrent abscesses, pneumonia and recurrent candida infections. Eczema usually occurs in the creases behind the ears, the back, buttocks and scalp. Boils and abscesses are commonly caused by bacteria called as staphylococcal aureus.
Immunoglobulin E (IgE) is an antibody that is produced by the bodyâs immune system in response to a perceived threat.It is one of five classes of immunoglobulins (A, G, M, D, and E) and is normally present in the blood in very small amounts. This test measures the amount of IgE in the blood.uring an initial exposure, also called sensitization, an allergic person produces an IgE specifically directed against that allergen. IgE binds to specialized white blood cells, resulting in the release of a number of substances, including histamine.