Obesity can unfavourably alter hormonal and metabolic status via resistance to the hormone <answer>leptin</answer>, and a vicious cycle may occur in which insulin/<answer>leptin</answer> resistance and obesity aggravate one another. The vicious cycle is putatively fuelled by continuously high insulin/<answer>leptin</answer> stimulation and fat storage, as a result of high intake of strongly insulin/<answer>leptin</answer> stimulating foods and energy. Both insulin and <answer>leptin</answer> normally function as satiety signals to the hypothalamus in the brain; however, insulin/<answer>leptin</answer> resistance may reduce this signal and therefore allow continued overfeeding despite large body fat stores. In addition, reduced <answer>leptin</answer> signalling to the brain may reduce <answer>leptin</answer>'s normal effect to maintain an appropriately high metabolic rate.
Obesity can cause resistance to which hormone?
leptin