The <answer>proportion of non-repetitive DNA</answer> is calculated by using the length of non-repetitive DNA divided by genome size. Protein-coding genes and RNA-coding genes are generally non-repetitive DNA. A bigger genome does not mean more genes, and the <answer>proportion of non-repetitive DNA</answer> decreases along with increasing genome size in higher eukaryotes.
In higher eukaryotes, what has an inverse relationship with genome size?
proportion of non-repetitive DNA