With the death of Zhengde and ascension of <answer>Jiajing</answer>, the politics at court shifted in favor of the Neo-Confucian establishment which not only rejected the Portuguese embassy of Fernão Pires de Andrade (d. 1523), but had a predisposed animosity towards Tibetan Buddhism and lamas. Evelyn S. Rawski, a professor in the Department of History of the University of Pittsburgh, writes that the Ming's unique relationship with Tibetan prelates essentially ended with <answer>Jiajing</answer>'s reign while Ming influence in the Amdo region was supplanted by the Mongols.
Who was Zhengde's successor? 
Jiajing