Most of the Low Countries had come under the rule of the House of Burgundy and subsequently the House of Habsburg. In 1549 Holy Roman Emperor Charles V issued the Pragmatic Sanction, which further unified the Seventeen Provinces under his rule. Charles was succeeded by his son, King Philip II of Spain. In <answer>1568</answer> the Netherlands, led by William I of Orange, revolted against Philip II because of high taxes, persecution of Protestants by the government, and Philip's efforts to modernize and centralize the devolved-medieval government structures of the provinces. This was the start of the Eighty Years' War.
In what year did the Netherlands rise up against Philip II?
1568