Intermittent warfare lasting from July 23, 1670 until July 1695, plus the typhoons of 1671 and 1693, and in particular the smallpox epidemic of <answer>1688</answer>, reduced the Chamorro population from 50,000 to 10,000 to less than 5,000.:86 Precipitated by the death of Quipuha, and the murder of Father San Vitores and Pedro Calungsod by local rebel chief Matapang, tensions led to a number of conflicts. Captain Juan de Santiago started a campaign to pacify the island, which was continued by the successive commanders of the Spanish forces.:68–74
When did the Smallpox epidemic take place?
1688